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和田裕雄（ワダヒロオ）

研究テーマ	呼吸器病学、加齢医学、産業医学、公衆衛生学、睡眠予防医学
研究業績（論文）	Wada H, Yasuda Y. Value Effect of Health and Productivity Management: An Event Study of the HPM Award in Japan. J Occup Environ Med. 2022; 64(6): 465-469. Wada H, Nakamura M, Inoue SI, Kudo A, Hanawa T, Iwakura Y, Kobayashi F, Kamma H, Kamiya S, Ito K, Barnes PJ, Takizawa H. Dual Interleukin-17A/F Deficiency Protects against Acute and Chronic Response to Cigarette Smoke Exposure in Mice. Sci Rep 2021, 11: 11508. doi: 10.1038/s41598-021-90853-9. Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H. Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort, The JACC Study. Sci Rep 2021; 11: 1531. doi: 10.1038/s41598-020-79860-4. Wada H, Kondo K, Tanigawa T. Snoring is a pathogenic symptom: A need for its objective assessment. Geriatr Gerontol Int. 2020; 20(6): 648-649. Wada H, Furuya S, Maruyama K, Ikeda A, Kondo K, Tanigawa T, on behalf of JAGES group. The prevalence and clinical impact of snoring in older community-dwelling adults. Geriatr Gerontol Int 2019; 19: 1165-1171. Wada H, Kimura M, Shiarahama R, Ikeda A, Gozal D, Tanigawa T. Pectus excavatum is associated with sleep-related breathing disorders in children. Eur Respir J 2019; 54: pii: 1900524. Wada H, Nagata K, Shirahama R, Tajima T, Kimura M, Ikeda A, Maruayma K, Tamura M, Suzuki K, Tanigawa T. The impact of sleep disordered breathing on performance in Judo players. BMJ Open Sport Exerc Med 2019; 5: e000418. (Official Journal of British Association of Sport and Exercise Medicine.) Wada H, Fukumoto S, Tamamura K, Muto G, Ueki J, Tanigawa T. Toward the harmonization of work with treatment and prevention for patients with chronic respiratory failure. Ind Health 2019; 57: 84-89. Wada H, Kimura M, Shirahama R, Tajima T, Maruyama K, Endo M, Ikeda A, Tanigawa T. Harmonizing work with the treatment and prevention of sleep disordered breathing in commercial motor vehicle drivers: implications for Health and Productivity Management. Ind Health 2019; 57: 3-9. Wada H, Kimura M, Tajima T, Shirahama R, Suzuki Y, Suzuki Y, Hayashi T, Maruyama K, Endo M, Sakamoto N, Ikeda A, Gozal D, Tanigawa T. Nocturnal enuresis and sleep disordered breathing in primary school children: potential implications. Pediatir Pulm 2018, 53: 1541-1548. Wada H, Shirahama R, Kimura M, Tajima T, Inoshita A, Tanigawa T. Sleep Disordered Breathing in Children. Juntendo Med J 2017; 63: 443-448. Wada H, Ikeda A, Kales SA, Tanigawa T. Screening for sleep disordered breathing (SDB) in truck drivers in the US. Juntendo Med J 2015; 61: 350-351. Wada H, Inui T, Nakamoto K, Sada M, Nakamura M, Takizawa H. A pivotal Role of Nrf2 in Airway Inflammatory Responses Inducedby Diesel Exhaust in Asthma: Mechanisms and Their Application to Clinical Interventions. 2015 in press. Wada H, Akiyama Y, Takeda H, Nakamura M, Takizawa H. Social isolation in patients with chronic respiratory failure (CRF), undergoing long-term oxygen therapy (LTOT). J Am Geriatr Soc 2014; 62: 1807-1808. Wada H, Hagiwara S, Yamamoto Y and Takizawa H. Links between lung dysfunction and glucose metabolism dysregulation: does lung dysfunction represent a systemic disorder? Intern Med 2014; 53; 2413-2414. Kobayashi Y, Wada H, Rossios C, Takagi D, Charron C, Barnes PJ and Ito K. “A novel macrolide/fluoroketolide, splithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition",　Br J Pharmacol 2013; 169: 1024-1034. Koybayashi Y, Wada H, Rossios C, Takagi D, Higaki M, Mikura S, Goto H and Barnes PJ. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-B inhibition. J Pharmacol Exp Ther 2013; 345: 76-85. [doi: 10.1124/jpet.112.200733.] Yasutake T, Wada H, Higaki M, Nakamura M, Honda K, Watanabe M, Ishii H, Kamiya S, Takizawa H, and Goto H. Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549. F1000Research 2013, 2: 78 [doi: 10.12688/f1000research. 2-78.v1]. Wada H and Takizawa H. Future Treatment for COPD: targeting oxidative stress and its related signal. Recent Pat Inflamm Allergy Drug Discov 2013; 7: 1-11.[ doi: 10.2174/1872213X11307010001] Ohnishi H, Yonetani S, Matsushima S, Wada H, Takeshita K, Kuramochi D, De Souza PC, Campos CED, Da Costa BP, Ramos JP, Mikura S, Narisawa E, Fujita A, Funayama Y, Kobashi Y, Sakakibara Y, Ishiyama Y, Takakura S, Goto H, Watanabe T. Mycobacterium kyorinense Infection: Clinical Features and Antimicrobial Susceptibility. Emerg Infect Dis 2013; 19: 508-510.[ doi: 10.3201/eid1903.120591] 1Hiraoka S, Wada H, MoritaK, Honda K, Koyanagi M, Y okoyama K, Fukuchi Y, Nitatori T, Goto H. Pulmonary volumetric analyses based on three-dimensional computed tomography (3D-CT), compared with pulmonary function test. Jpn J Diagn Imaging 2012; 30: 145-155. (*equal contribution to this publication.) Wada H, Hagiwara S, Saitoh E, Ieki R, Yamamoto Y, Adcock IM and Goto H. Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease (COPD). BioMarkers 2012; 17: 520-523. [doi: 10.3109/1354750X.2012.692393.] Watanabe A, Goto H, Soma K, Kikuchi T, Gomi K, Miki H, Maemondo M, Ikeda H, Kuroki J, Wada H, Yokoyama T, Izumi S, Mitsutake K and Ueda Y “Usefulness of linezolid in the treatment of hospital-acquired pneumonia caused by MRSA: a prospective observational study” J Infect Chemother 2012; 18: 160-168. Saraya T, Nakata K, Nakagaki K, Motoi N, Iihara K, Fujioka Y, Oka T, Kurai D, Wada H, Ishii H, Taguchi H, Kamiya S and Goto H. “Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.” Results in Immunology 2011; 1: 76-87. Mikura S, Wada H, Okazaki M, Nakamura M, Honda K, Yasutake T, Higaki M, Ishii T, Watanabe T, Tsunoda T and Goto H. “Risk factors for bacteraemia attributable to Pseudomonas aeruginosa resistant to imipenem, levofloxacin, or gentamicin.” J Hosp Infect 2011; 79: 267-268. Takata S, Wada H, Tamura M, Koide T, Higaki M, Mikura S, Yasutake T, Hirao S, Nakamura M, Honda K, Nagatomo T, Tanaka Y, Watanabe M, Yokoyama T, Saraya T, Kurai D, Ishii H and Goto H. "Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community acquired pneumonia (CAP), as presented with biologic half-life times.” BioMarkers 2011; 16: 530-535. Ohshima N, Matsui H, Matsui Y, Kawashima M, Shimada M, Higaki N, Shoji S, Wada H, Fujita A, Watanabe H, Yamaguchi N, Matsuoka R, Oki K, Takahashi H, Suzuki M, Yamazaki H , Yoshizawa M and Goto H “Addition of leukotriene receptor antagonists to inhaled corticosteroids improved QOL of patients with bronchial asthma surveyed in suburban Tokyo, Japan.” Allergol Int 2011; 60: 473-481. Hirao S, Wada H, Nakagaki K, Saraya T, Kurai D, Mikura S, Yasutake T, Higaki M, Yokoyama T, Ishii H, Nakata K, Akashi T, Kamiya S and Goto H. “Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone” FEMS Immunology & Medical Microbiology 2011; 62: 182-189. Mikura S, Wada H, Higaki M, Yasutake T, Ishii H, Kamiya S and Goto H “Erythromycin prevents the pulmonary inflammation induced by exposure to cigarette smoke” Transl Res 2011; 158: 30-37. Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Goto H, Bemis JE, Elliott P, Barnes PJ and Ito K “A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9” FASEB J 2009; 23: 2810-2819 Wada H, Yamamoto M, Okazaki M, Watanabe T and Goto H. Isolation of Mycobacterium kyorinense in a patient with respiratory failure. Ann Intern Med 2009; 150: 568-570 Wada H, Hagiwara S, Goto H and Yamamoto Y, The redox status of coenzyme Q10 associated to the chronological age. J Am Geriatrics Soc 2007; 55: 1141-1142. Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Iguchi M, Yuasa K, Kodaka T, Koishi T, Yamamoto Y and Goto H. Increased oxidative stress in patients with chronic obstructive pulmonary disesase (COPD) as measured by redox status of plasma coenzyme Q10. Pathophysiology 2006; 13: 29-33. Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Kodaka T, Yamamoto Y and Goto H. Reduction in Plasma Free Fatty Acid in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2005; 171: 1465. Wada H, Kagoshima M, Ito K, Barnes PJ and Adcock IM. 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene. Biochem Biophys Res Comm 2005; 331: 93-99.

研究テーマ

呼吸器病学、加齢医学、産業医学、公衆衛生学、睡眠予防医学

研究業績（論文）

Wada H, Yasuda Y. Value Effect of Health and Productivity Management: An Event Study of the HPM Award in Japan. J Occup Environ Med. 2022; 64(6): 465-469.

Wada H, Nakamura M, Inoue SI, Kudo A, Hanawa T, Iwakura Y, Kobayashi F, Kamma H, Kamiya S, Ito K, Barnes PJ, Takizawa H. Dual Interleukin-17A/F Deficiency Protects against Acute and Chronic Response to Cigarette Smoke Exposure in Mice. Sci Rep 2021, 11: 11508. doi: 10.1038/s41598-021-90853-9.

Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H. Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort, The JACC Study. Sci Rep 2021; 11: 1531. doi: 10.1038/s41598-020-79860-4.

Wada H, Kondo K, Tanigawa T. Snoring is a pathogenic symptom: A need for its objective assessment. Geriatr Gerontol Int. 2020; 20(6): 648-649.

Wada H, Furuya S, Maruyama K, Ikeda A, Kondo K, Tanigawa T, on behalf of JAGES group. The prevalence and clinical impact of snoring in older community-dwelling adults. Geriatr Gerontol Int 2019; 19: 1165-1171.

Wada H, Kimura M, Shiarahama R, Ikeda A, Gozal D, Tanigawa T. Pectus excavatum is associated with sleep-related breathing disorders in children. Eur Respir J 2019; 54: pii: 1900524.

Wada H, Nagata K, Shirahama R, Tajima T, Kimura M, Ikeda A, Maruayma K, Tamura M, Suzuki K, Tanigawa T. The impact of sleep disordered breathing on performance in Judo players. BMJ Open Sport Exerc Med 2019; 5: e000418. (Official Journal of British Association of Sport and Exercise Medicine.)

Wada H, Fukumoto S, Tamamura K, Muto G, Ueki J, Tanigawa T. Toward the harmonization of work with treatment and prevention for patients with chronic respiratory failure. Ind Health 2019; 57: 84-89.

Wada H, Kimura M, Shirahama R, Tajima T, Maruyama K, Endo M, Ikeda A, Tanigawa T. Harmonizing work with the treatment and prevention of sleep disordered breathing in commercial motor vehicle drivers: implications for Health and Productivity Management. Ind Health 2019; 57: 3-9.

Wada H, Kimura M, Tajima T, Shirahama R, Suzuki Y, Suzuki Y, Hayashi T, Maruyama K, Endo M, Sakamoto N, Ikeda A, Gozal D, Tanigawa T. Nocturnal enuresis and sleep disordered breathing in primary school children: potential implications. Pediatir Pulm 2018, 53: 1541-1548.

Wada H, Shirahama R, Kimura M, Tajima T, Inoshita A, Tanigawa T. Sleep Disordered Breathing in Children. Juntendo Med J 2017; 63: 443-448.

Wada H, Ikeda A, Kales SA, Tanigawa T. Screening for sleep disordered breathing (SDB) in truck drivers in the US. Juntendo Med J 2015; 61: 350-351.

Wada H, Inui T, Nakamoto K, Sada M, Nakamura M, Takizawa H. A pivotal Role of Nrf2 in Airway Inflammatory Responses Inducedby Diesel Exhaust in Asthma: Mechanisms and Their Application to Clinical Interventions. 2015 in press.

Wada H, Akiyama Y, Takeda H, Nakamura M, Takizawa H. Social isolation in patients with chronic respiratory failure (CRF), undergoing long-term oxygen therapy (LTOT). J Am Geriatr Soc 2014; 62: 1807-1808.

Wada H, Hagiwara S, Yamamoto Y and Takizawa H. Links between lung dysfunction and glucose metabolism dysregulation: does lung dysfunction represent a systemic disorder? Intern Med 2014; 53; 2413-2414.

Kobayashi Y, Wada H, Rossios C, Takagi D, Charron C, Barnes PJ and Ito K. “A novel macrolide/fluoroketolide, splithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition",　Br J Pharmacol 2013; 169: 1024-1034.

Koybayashi Y, Wada H, Rossios C, Takagi D, Higaki M, Mikura S, Goto H and Barnes PJ. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-B inhibition. J Pharmacol Exp Ther 2013; 345: 76-85. [doi: 10.1124/jpet.112.200733.]

Yasutake T, Wada H, Higaki M, Nakamura M, Honda K, Watanabe M, Ishii H, Kamiya S, Takizawa H, and Goto H. Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549. F1000Research 2013, 2: 78 [doi: 10.12688/f1000research. 2-78.v1].

Wada H and Takizawa H. Future Treatment for COPD: targeting oxidative stress and its related signal. Recent Pat Inflamm Allergy Drug Discov 2013; 7: 1-11.[ doi: 10.2174/1872213X11307010001]

Ohnishi H, Yonetani S, Matsushima S, Wada H, Takeshita K, Kuramochi D, De Souza PC, Campos CED, Da Costa BP, Ramos JP, Mikura S, Narisawa E, Fujita A, Funayama Y, Kobashi Y, Sakakibara Y, Ishiyama Y, Takakura S, Goto H, Watanabe T. Mycobacterium kyorinense Infection: Clinical Features and Antimicrobial Susceptibility. Emerg Infect Dis 2013; 19: 508-510.[ doi: 10.3201/eid1903.120591]

1Hiraoka S*, Wada H*, MoritaK, Honda K, Koyanagi M, Y okoyama K, Fukuchi Y, Nitatori T, Goto H. Pulmonary volumetric analyses based on three-dimensional computed tomography (3D-CT), compared with pulmonary function test. Jpn J Diagn Imaging 2012; 30: 145-155. (*equal contribution to this publication.)

Wada H, Hagiwara S, Saitoh E, Ieki R, Yamamoto Y, Adcock IM and Goto H. Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease (COPD). BioMarkers 2012; 17: 520-523. [doi: 10.3109/1354750X.2012.692393.]

Watanabe A, Goto H, Soma K, Kikuchi T, Gomi K, Miki H, Maemondo M, Ikeda H, Kuroki J, Wada H, Yokoyama T, Izumi S, Mitsutake K and Ueda Y “Usefulness of linezolid in the treatment of hospital-acquired pneumonia caused by MRSA: a prospective observational study” J Infect Chemother 2012; 18: 160-168.

Saraya T, Nakata K, Nakagaki K, Motoi N, Iihara K, Fujioka Y, Oka T, Kurai D, Wada H, Ishii H, Taguchi H, Kamiya S and Goto H. “Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.” Results in Immunology 2011; 1: 76-87.

Mikura S, Wada H, Okazaki M, Nakamura M, Honda K, Yasutake T, Higaki M, Ishii T, Watanabe T, Tsunoda T and Goto H. “Risk factors for bacteraemia attributable to Pseudomonas aeruginosa resistant to imipenem, levofloxacin, or gentamicin.” J Hosp Infect 2011; 79: 267-268.

Takata S, Wada H, Tamura M, Koide T, Higaki M, Mikura S, Yasutake T, Hirao S, Nakamura M, Honda K, Nagatomo T, Tanaka Y, Watanabe M, Yokoyama T, Saraya T, Kurai D, Ishii H and Goto H. "Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community acquired pneumonia (CAP), as presented with biologic half-life times.” BioMarkers 2011; 16: 530-535.

Ohshima N, Matsui H, Matsui Y, Kawashima M, Shimada M, Higaki N, Shoji S, Wada H, Fujita A, Watanabe H, Yamaguchi N, Matsuoka R, Oki K, Takahashi H, Suzuki M, Yamazaki H , Yoshizawa M and Goto H “Addition of leukotriene receptor antagonists to inhaled corticosteroids improved QOL of patients with bronchial asthma surveyed in suburban Tokyo, Japan.” Allergol Int 2011; 60: 473-481.

Hirao S, Wada H, Nakagaki K, Saraya T, Kurai D, Mikura S, Yasutake T, Higaki M, Yokoyama T, Ishii H, Nakata K, Akashi T, Kamiya S and Goto H. “Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone” FEMS Immunology & Medical Microbiology 2011; 62: 182-189.

Mikura S, Wada H, Higaki M, Yasutake T, Ishii H, Kamiya S and Goto H “Erythromycin prevents the pulmonary inflammation induced by exposure to cigarette smoke” Transl Res 2011; 158: 30-37.

Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Goto H, Bemis JE, Elliott P, Barnes PJ and Ito K “A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9” FASEB J 2009; 23: 2810-2819

Wada H, Yamamoto M, Okazaki M, Watanabe T and Goto H. Isolation of Mycobacterium kyorinense in a patient with respiratory failure. Ann Intern Med 2009; 150: 568-570

Wada H, Hagiwara S, Goto H and Yamamoto Y, The redox status of coenzyme Q10 associated to the chronological age. J Am Geriatrics Soc 2007; 55: 1141-1142.

Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Iguchi M, Yuasa K, Kodaka T, Koishi T, Yamamoto Y and Goto H. Increased oxidative stress in patients with chronic obstructive pulmonary disesase (COPD) as measured by redox status of plasma coenzyme Q10. Pathophysiology 2006; 13: 29-33.

Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Kodaka T, Yamamoto Y and Goto H. Reduction in Plasma Free Fatty Acid in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2005; 171: 1465.

Wada H, Kagoshima M, Ito K, Barnes PJ and Adcock IM. 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene. Biochem Biophys Res Comm 2005; 331: 93-99.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

和田 裕雄（ワダ ヒロオ）

和田裕雄（ワダヒロオ）