学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

北浦次郎（キタウラジロウ）

研究テーマ	アレルギー・炎症性疾患の制御機構
研究業績（論文）	2009-2023年度英文原著・総説 1. Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K: TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 2023 (in press). 2. Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, Maehara A, Kojima M, Yamamoto R, Wang H, Nagamine M, Maeda K, Uchida K, Nakano N, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Kitaura J: Staphylococcus aureus d-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 14: 1173069, 2023. 3. Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J: The protective role of conjunctival goblet cell mucin sialylation. Nat Commun. 14: 1417, 2023 4. Ando T, Kitaura J, Maruyama N, Narita M, Miura K, Takasato Y, Nogami K, Nagao M, Okumura K, Ogawa H, Onishi H, Watanabe T, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Hasegawa S, Ohya Y, Yasudo H: Sensitization to macadamia 7S globulin amino-terminus with clinical relevance in Japanese children with macadamia nut allergy. Allergol Int. 72: 351-353, 2023. 5. Kamei A, Izawa K, Ando T, Kaitani A, Yamamoto R, Maehara A, Ide T, Yamada H, Kojima M, Wang H, Tokushige K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper. Front Immunol. 13: 945222, 2022. 6. Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 132: e156501, 2022. 7. Yasudo H, Ando T, Kitaura J, Maruyama N, Narita M, Natsume O, Uneoka K, Miura K, Morita Y, Kamei A, Okamoto Y, Shirakawa S, Kitabayashi T, Kurihara K, Nogami K, Takasato Y, Nagao M, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Saito H, Hasegawa S, Ohya Y: Predictive value of 7S globulin-specific IgE in Japanese macadamia nut allergy patients. J Allergy Clin Immunol Pract. 10: 1389-1391, 2022. 8. Nakano N, Kitaura J: Mucosal mast cells as key effector cells in food allergies. Cells. 11: 329, 2022. 9. Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K: Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling. J Immunol. 207: 3098-3106, 2021. 10. Nakahashi-Oda C, Fujiyama S, Nakazawa Y, Kanemaru K, Wang Y, Lyu W, Shichita T, Kitaura J, Abe F, Shibuya A: CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke. Sci Immunol. 6: eabe7915, 2021. 11. Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J: Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice. Ocul Surf. 22: 153-162, 2021. 12. Kitaura J, Murakami M: Positive and negative roles of lipids in mast cells and allergic responses. Curr Opin Immunol. 72: 186-195, 2021. 13. Ando T, Kitaura J: Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions. Cells. 10: 1697, 2021. 14. Yasudo H, Ando T, Maehara A, Ando T, Izawa K, Tanabe A, Kaitani A, Nomura S, Seki M, Yoshida K, Oda H, Okamoto Y, Wang H, Kamei A, Kojima M, Kimura M, Uchida K, Nakano N, Kaneko J, Ebihara N, Hasegawa K, Shimizu T, Takita J, Ogawa H, Okumura K, Ogawa S, Tamura N, Kitaura J: A Possible Association Between a Nucleotide-Binding Domain LRR-Containing Protein Family PYD-Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis. Hepatology. 74: 2296-2299, 2021. 15. Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14: 640-651, 2021. 16. Fujimoto K, Uchida K, Yin E, Zhu J, Kojima Y, Uchiyama M, Yamamoto Y, Bashuda H, Matsumoto R, Tokushige K, Harada M, Inomata T, Kitaura J, Murakami A, Okumura K, Takeda K: Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation. Transpl Immunol. 67: 101405, 2021. 17. Yin E, Fukuhara T, Takeda K, Kojima Y, Fukuhara K, Ikejima K, Bashuda H, Kitaura J, Yagita H, Okumura K, Uchida K: Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury. Sci Rep. 11: 6312, 2021. 18. Yoneyama T, Nakano N, Hara M, Yamada H, Izawa K, Uchida K, Kaitani A, Ando T, Kitaura J, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J Allergy Clin Immunol. 147: 1063-1076, 2021. 19. Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J: CD300f is a potential therapeutic target for the treatment of food allergy. Allergy. 75: 471-474, 2020. 20. Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J: Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain. J Invest Dermatol. 140: 710-713, 2020. 21. Takahashi M, Izawa K, Urai M, Yamanishi Y, Maehara A, Isobe M, Matsukawa T, Kaitani A, Takamori A, Uchida S, Yamada H, Nagamine M, Ando T, Shimizu T, Ogawa H, Okumura K, Kinjo Y, Kitamura T, Kitaura J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12: 564, 2019. 22. Takamori A, Izawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation. J Allergy Clin Immunol. 143: 1231-1235, 2019. 23. Hayashi Y, Harada Y, Kagiyama Y, Nishikawa S, Ding Y, Imagawa J, Shingai N, Kato N, Kitaura J, Hokaiwado S, Maemoto Y, Ito A, Matsui H, Kitabayashi I, Iwama A, Komatsu N, Kitamura T, Harada H: NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis. Blood Adv. 3: 1047-1060, 2019. 24. Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S: Receptor destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis. J Biol Chem. 294: 6659-6669, 2019. 25. Negishi N, Sato T, Yamashita-Kanemaru Y, Shibuya K, Uchida K, Kametani Y, Yagita H, Kitaura J, Okumura K, Habu S: CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity. ImmunoHorizons. 2:338-348, 2018. 26. Ueno K, Urai M, Izawa K, Otani Y, Yanagihara N, Kataoka M, Takatsuka S, Abe M, Hasegawa H, Shimizu K, Kitamura T, Kitaura J, Miyazaki Y, Kinjo Y: Mouse LMIR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils. Sci Rep. 8: 17406, 2018. 27. Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J: The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Sci Rep. 8:14237, 2018. 28. Kaitani A, Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: 　Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8:8259, 2018. 29. Takamori A, Nambu A, Sato K, Yamaguchi S, Matsuda K, Numata T, Sugawara T, Yoshizaki T, Arae K, Morita H, Matsumoto K, Sudo K, Okumura K, Kitaura J, Matsuda H, Nakae S: IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Sci Rep. 8:6639, 2018. 30. Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805, 2018. 31. Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J Invest Dermatol. 138:1221-1224, 2018. 32. Kawabata KC, Hayashi Y, Inoue D, Meguro H, Sakurai H, Fukuyama T, Tanaka Y, Asada S, Fukushima T, Nagase R, Takeda R, Harada Y, Kitaura J, Goyama S, Harada H, Aburatani H, Kitamura T: High expression of ABCG2 induced by EZH2 disruption plays pivotal roles in MDS pathogenesis. Leukemia. 32:419-428, 2018. 33. Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 7:4298, 2017. 34. Honjo A, Nakano N, Yamazaki S, Hara M, Uchida K, Kitaura J, Nishiyama C, Yagita H, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia. J Allergy Clin Immunol. 139:987-996, 2017. 35. Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J: Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 292: 2924-2932, 2017. 36. Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J: Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65: 777-87, 2016. 37. Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y, Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S, Fukuyama T, Tanaka Y, Ono R, Goyama S, Nosaka T, Kitaura J, Inoue D: Novel working hypothesis for pathogenesis of hematological malignancies: Combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). J Biochem. 159: 17-25, 2016. 38. Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Lamine Hafirassou M, Kitaura J, Ramdasi R, Schwartz O, Amara A: The phosphatidylserine and phosphatidylethanolamine receptor CD300a binds dengue virus and enhances infection. J Virol. 90: 92-102, 2015. 39. Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, Kitaura J, Ohtsuka Y, Okumura K, Ogawa H, Shimizu T: The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells. J Immunol. 195: 3427-3435, 2015. 40. Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T: A C-terminal mutant of C/EBP (C/EBPa-Cm) down-regulates the Csf1r, a potent accelerator in the progression of AML with C/EBPa-Cm. Exp Hematol. 43: 300-308, 2015. 41. Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T: SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS. Leukemia. 29: 847-857 2015. 42. Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcRI-mediated mast cell activation. J Allergy Clin Immunol. 133: 270-273, 2014. 43. Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T: A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4: 4012, 2014. 44. Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T: Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42: 369-379, 2014. 45. Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T: Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123: 3932-3942, 2014. 46. Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, Enomoto Y, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nagase R, Horikawa S, Hayashi Y, Saika M, Fukuyama T, Izawa K, Oki T, Nakahara F, Kitaura J. The molecular basis of myeloid malignancies. Proc Jpn Acad Ser B Phys Biol Sci. 90, 389-404, 2014. 47. Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J. Human CD300C Delivers an Fc Receptor-γ-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition. J Biol Chem. 288: 7662-7675, 2013. 48. Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M: The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model. Blood. 121: 4142-4155, 2013. 49. Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, Kitamura T: APCCDH1 targets MgcRacGAP for destruction in the late M phase. PLOS One. 8, e63001, 2013. 50. Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T: Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest. 123: 4627-4640, 2013. 51. Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J: The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37: 827-839, 2012. 52. Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J: A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis. J Immunol. 189, 1773-1779, 2012. 53. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K: PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 24: 613-623, 2012. 54. Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T: Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. Int J Hematol. 96: 638-648, 2012. 55. Enomoto Y, Kitaura J, Shimanuki M, Kato N, Nishimura K, Takahashi M, Nakakuma H, Kitamura T, Sonoki T: MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia. Int J Hematol. 96: 334-341, 2012. 56. Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T: Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest. 122: 218-228, 2012. 57. Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, Kitamura T: Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis. Leukemia. 26: 1038-1045, 2012. 58. Nakamura M, Kitaura J, Enomoto Y, Lu Y, Nishimura K, Isobe M, Ozaki K, Komeno Y, Nakahara F, Oki T, Kume H, Homma Y, Kitamura T: Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis. Cancer Sci. 103: 26-33, 2012. 59. Shibata-Minoshima F, Oki T, Doki N, Nakahara F, Kageyama S, Kitaura J, Fukuoka J, Kitamura T: Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning. Int J Oncol. 40: 93-98, 2012. 60. Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T: Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int J Hematol. 95: 167-175, 2012. 61. Enomoto Y, Kitaura J, Hatakeyama K, Watanuki J, Akasaka T, Kato N, Shimanuki M, Nishimura K, Takahashi M, Taniwaki M, Haferlach C, Siebert R, Dyer MJ, Asou N, Aburatani H, Nakakuma H, Kitamura T, Sonoki T: Eμ/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia. 25: 1849-1856, 2011. 62. Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K, Nakahara, F, Oki T, Enomoto Y, Fukuchi Y, Nakajima H, Harada Y, Harada H, Kitamura T: Two types of C/EBP mutations play distinct but collaborative roles in leukemogenesis: Lessons from clinical data and BMT models. Blood. 117: 221-233, 2011. 63. Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takamatsu R, Kajikawa M, Takai T, Kitamura T, Kitaura J: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem. 285: 35274-35283, 2010. 64. Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207: 1501-1511, 2010. 65. Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T: AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Leukemia. 24: 1018-1024, 2010. 66. Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura, T, Nosaka T: Expression of ADAMTS4 in Ewing's sarcoma. Int J Oncol. 37: 569-581, 2010. 67. Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S: Hes1 immortalizes committed progenitors and plays a role in blastic crisis of chronic myelogenous leukemia. Blood. 115: 2872-2881, 2010. 68. Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J: Evidence that integrinIIb3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J Biol Chem. 284: 31463-31472, 2009. 69. Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol. 183: 925-936, 2009. 70. Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R, Harada Y, Harada H, Hayashi Y, Nakajima H, Nosaka T, Kitaura J, Kitamura T: Possible involvement of RasGRP4 in leukemogenesis. Int J Hematol. 89: 470-481, 2009. 71. Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y, Kitaura J, Honda Z, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura, Honda H: Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. Blood. 113: 4702-4710, 2009. 72. Komeno Y, Kitaura J, Kitamura T: Molecular bases of myelodysplastic　syndromes:　lessons from animal models. J Cell Physiol. 219: 529-534, 2009. 2009-2023年度　和文総説 1. 貝谷綾子、伊沢久未、井出拓磨、前原明絵、安藤智暁、北浦次郎: FcRIの制御機構（解説）、臨床免疫・アレルギー科。79：　300－306、2023。 2. 安東泰希、前原明絵、田村直人、北浦次郎：自己炎症性疾患における原因遺伝子解析、リウマチ科。68：371‐378、2022。 3. 中野信浩、米山俊之、北浦次郎：経口免疫療法による食物アレルギー症状の発生抑制のメカニズム、アロスエルゴン。2：729‐735、2022。 4. 北浦次郎、伊沢久未、貝谷綾子：＜アレルギー研究の展望＞ペア型免疫受容体とアレルギー疾患、アレルギーの臨床。42：15-19、2022。 5. 北浦次郎：IgEの生物学的役割、アロスエルゴン。1：122-124、2021。 6. 伊沢久未、貝谷綾子、北浦次郎：アレルギー疾患と抑制化受容体(特集:抑制化受容体と免疫応答)、炎症と免疫。29：13-18、2021。 7. 貝谷綾子、伊沢久未、内田志野、亀井杏菜、前原明絵、安藤智暁、北浦次郎: CD300f分子とアレルギー（解説）、臨床免疫・アレルギー科。75：218-225、2021 8. 内田志野、伊沢久未、安藤智暁、貝谷綾子、北浦次郎：CD300は食物アレルギーの治療標的となりうる。臨床免疫・アレルギー科。74：398-405、2020。 9. 貝谷綾子、高森絢子、安藤智暁、伊沢久未、北浦次郎：薬剤による偽アレルギーにおけるCD300fの役割について。臨床免疫・アレルギー科。72：122-128、2019。 10. 伊沢久未、奥村康、北浦次郎：抑制型免疫受容体CD300fとセラミド＜セラミド研究の新展開～基礎から応用へ～＞、セラミド研究会、食品化学新聞社。118-124、2019。 11. 北浦次郎、免疫とは何か？＜連載（免疫を知る）第１回＞、保健の科学。61：63-68、2019。 12. 貝谷綾子、前原明絵、高森綾子、伊沢久未、北浦次郎：セラミドと皮膚アレルギー・炎症。臨床免疫・アレルギー科。69：576-582、2018。 13. 伊沢久未、前原明絵、貝谷綾子、高森綾子、北浦次郎：敗血症性腹膜炎におけるCD300fとセラミドの役割。臨床免疫・アレルギー科。69：250-256、2018。 14. 前原秋絵、北浦次郎：LMIR3のアレルギーに対するブレーキメカニズムと今後の応用。COSMETIC STAGE。11：53-57、2017。 15. 北浦次郎：古くて新しいIgE（IgEをめぐる諸問題　アップデート）。アレルギー・免疫。23：1615-1619、2016。 16. 伊沢久未、貝谷綾子、前原明絵、北浦次郎：マスト細胞およびIgE依存性のアナフィラキシーを制御する受容体について。臨床免疫・アレルギー科。66：571-575、2016。 17. 松川敏大、北村俊雄、北浦次郎：LMIR3/CD300fによる実験的腸炎の制御：LMIR3とセラミドの結合はATPによる腸管マスト細胞の活性化を抑制する。臨床免疫・アレルギー科。64：374-379、2015。 18. 北浦次郎、北村俊雄、奥村康、伊沢久未：アトピー性皮膚炎におけるセラミドとLMIR3。臨床免疫・アレルギー科。63：151-155、2015。 19. 北浦次郎、伊沢久未、北村俊雄：LMIR3によるマスト細胞活性化の制御とアレルギー炎症の抑制。炎症と免疫。22：90-93、2014。　 20. 北浦次郎、伊沢久未、高橋まり子、北村俊雄：CD300群によるマスト細胞の活性化制御。臨床免疫・アレルギー科。61：384-390、2014。　 21. Kitamura T, Inoue D, Nakahara F, Okochi N, Kato N, Togami K, Uchida T, Kagiyama Y, Kawabata KC, Nagase R, Horikawa S, Hayashi K, Saika M, Izawa K, Oki T, Chiba S, Harada Y, Harada H, Kitaura J: Molecular basis of hematological malignancies. Rinsho Ketsueki. 55：1715-1723、2014。 22. 北浦次郎、伊沢久未、山西吉典、北村俊雄：LMIRの機能とリガンド。臨床免疫・アレルギー科。59：259-264、2013。 23. 北浦次郎、山西吉典、北村俊雄：CD300b/LMIR5と炎症。医学のあゆみ。245：229-233、2013。 24. 北浦次郎、伊沢久未、北村俊雄：LMIR3(CD300f)によるマスト細胞活性化の抑制。臨床免疫・アレルギー科。160：478-485、2013。 25. Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M: The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model. Rinsho Ketsueki. 54：749-758、2013。 26. Kitaura J, Izawa K, Kitamura T: An inhibitory receptor LMIR3/CD300f recognizes ceramide. Seikagaku. 85：1071-1075、2013。 27. 山西吉典、北浦次郎、北村俊雄: LMIR5のリガンドTIM1同定:LMIR5-TIM1の結合は腎虚血再還流障害を増悪させる。感染・炎症・免疫。41：321-323、2012。 28. 北浦次郎、伊沢久未、山西吉典、榎本豊、北村俊雄：CD300/LMIRファミリーとマスト細胞。臨床免疫・アレルギー科。58：190-196、2012。 29. 北浦次郎、伊沢久未、北村俊雄：アレルギーとマスト細胞＜抑制型レセプターLMIR3について＞。アレルギーの臨床。32：28-32、2012。 30. Kitamura T, Watanabe-Okochi N, Inoue D, Togami K, Uchida T, Kagiyama Y, Kawabata K, Chiba S, Harada Y, Harada H, Kitaura J, Nakahara F: Molecular mechanisms underlying leukemic transformation of myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML) Rinsho Ketsueki. 53：734-739、2012。 31. 伊沢久未、北浦次郎、北村俊雄: Leukocyte mono-Ig like receptor 3 (LMIR3)によるマスト細胞の活性化と抑制化。臨床免疫・アレルギー科。54：135-141、2010。 32. 伊沢久未、北浦次郎、北村俊雄: マスト細胞の活性化とLMIR3―抑制型レセプターであるLMIR3はマスト細胞においてFcRIと会合し、リポポリサッカライドによる反応を増強する―。臨床免疫・アレルギー科。53：321-328、2010。 33. 山西吉典、北浦次郎、北村俊雄: 活性型レセプターLMIR5によるマスト細胞の機能制御-マウスおよびヒトLMIR5の相違。臨床免疫・アレルギー科。52：40-48、 2009。

研究テーマ

アレルギー・炎症性疾患の制御機構

研究業績（論文）

2009-2023年度英文原著・総説

1. Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K: TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 2023 (in press).

2. Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, Maehara A, Kojima M, Yamamoto R, Wang H, Nagamine M, Maeda K, Uchida K, Nakano N, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Kitaura J: Staphylococcus aureus d-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 14: 1173069, 2023.

3. Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J: The protective role of conjunctival goblet cell mucin sialylation. Nat Commun. 14: 1417, 2023

4. Ando T, Kitaura J, Maruyama N, Narita M, Miura K, Takasato Y, Nogami K, Nagao M, Okumura K, Ogawa H, Onishi H, Watanabe T, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Hasegawa S, Ohya Y, Yasudo H: Sensitization to macadamia 7S globulin amino-terminus with clinical relevance in Japanese children with macadamia nut allergy. Allergol Int. 72: 351-353, 2023.

5. Kamei A, Izawa K, Ando T, Kaitani A, Yamamoto R, Maehara A, Ide T, Yamada H, Kojima M, Wang H, Tokushige K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper. Front Immunol. 13: 945222, 2022.

6. Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F: Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 132: e156501, 2022.

7. Yasudo H, Ando T, Kitaura J, Maruyama N, Narita M, Natsume O, Uneoka K, Miura K, Morita Y, Kamei A, Okamoto Y, Shirakawa S, Kitabayashi T, Kurihara K, Nogami K, Takasato Y, Nagao M, Ito K, Fujisawa T, Ebisawa M, Kawakami T, Matsumoto K, Saito H, Hasegawa S, Ohya Y: Predictive value of 7S globulin-specific IgE in Japanese macadamia nut allergy patients. J Allergy Clin Immunol Pract. 10: 1389-1391, 2022.

8. Nakano N, Kitaura J: Mucosal mast cells as key effector cells in food allergies. Cells. 11: 329, 2022.

9. Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K: Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling. J Immunol. 207: 3098-3106, 2021.

10. Nakahashi-Oda C, Fujiyama S, Nakazawa Y, Kanemaru K, Wang Y, Lyu W, Shichita T, Kitaura J, Abe F, Shibuya A: CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke. Sci Immunol. 6: eabe7915, 2021.

11. Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J: Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice. Ocul Surf. 22: 153-162, 2021.

12. Kitaura J, Murakami M: Positive and negative roles of lipids in mast cells and allergic responses. Curr Opin Immunol. 72: 186-195, 2021.

13. Ando T, Kitaura J: Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions. Cells. 10: 1697, 2021.

14. Yasudo H, Ando T, Maehara A, Ando T, Izawa K, Tanabe A, Kaitani A, Nomura S, Seki M, Yoshida K, Oda H, Okamoto Y, Wang H, Kamei A, Kojima M, Kimura M, Uchida K, Nakano N, Kaneko J, Ebihara N, Hasegawa K, Shimizu T, Takita J, Ogawa H, Okumura K, Ogawa S, Tamura N, Kitaura J: A Possible Association Between a Nucleotide-Binding Domain LRR-Containing Protein Family PYD-Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis. Hepatology. 74: 2296-2299, 2021.

15. Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14: 640-651, 2021.

16. Fujimoto K, Uchida K, Yin E, Zhu J, Kojima Y, Uchiyama M, Yamamoto Y, Bashuda H, Matsumoto R, Tokushige K, Harada M, Inomata T, Kitaura J, Murakami A, Okumura K, Takeda K: Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation. Transpl Immunol. 67: 101405, 2021.

17. Yin E, Fukuhara T, Takeda K, Kojima Y, Fukuhara K, Ikejima K, Bashuda H, Kitaura J, Yagita H, Okumura K, Uchida K: Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury. Sci Rep. 11: 6312, 2021.

18. Yoneyama T, Nakano N, Hara M, Yamada H, Izawa K, Uchida K, Kaitani A, Ando T, Kitaura J, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J Allergy Clin Immunol. 147: 1063-1076, 2021.

19. Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J: CD300f is a potential therapeutic target for the treatment of food allergy. Allergy. 75: 471-474, 2020.

20. Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J: Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain. J Invest Dermatol. 140: 710-713, 2020.

21. Takahashi M, Izawa K, Urai M, Yamanishi Y, Maehara A, Isobe M, Matsukawa T, Kaitani A, Takamori A, Uchida S, Yamada H, Nagamine M, Ando T, Shimizu T, Ogawa H, Okumura K, Kinjo Y, Kitamura T, Kitaura J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12: 564, 2019.

22. Takamori A, Izawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation. J Allergy Clin Immunol. 143: 1231-1235, 2019.

23. Hayashi Y, Harada Y, Kagiyama Y, Nishikawa S, Ding Y, Imagawa J, Shingai N, Kato N, Kitaura J, Hokaiwado S, Maemoto Y, Ito A, Matsui H, Kitabayashi I, Iwama A, Komatsu N, Kitamura T, Harada H: NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis. Blood Adv. 3: 1047-1060, 2019.

24. Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S: Receptor destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis. J Biol Chem. 294: 6659-6669, 2019.

25. Negishi N, Sato T, Yamashita-Kanemaru Y, Shibuya K, Uchida K, Kametani Y, Yagita H, Kitaura J, Okumura K, Habu S: CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity. ImmunoHorizons. 2:338-348, 2018.

26. Ueno K, Urai M, Izawa K, Otani Y, Yanagihara N, Kataoka M, Takatsuka S, Abe M, Hasegawa H, Shimizu K, Kitamura T, Kitaura J, Miyazaki Y, Kinjo Y: Mouse LMIR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils. Sci Rep. 8: 17406, 2018.

27. Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J: The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Sci Rep. 8:14237, 2018.

28. Kaitani A, Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: 　Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8:8259, 2018.

29. Takamori A, Nambu A, Sato K, Yamaguchi S, Matsuda K, Numata T, Sugawara T, Yoshizaki T, Arae K, Morita H, Matsumoto K, Sudo K, Okumura K, Kitaura J, Matsuda H, Nakae S: IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Sci Rep. 8:6639, 2018.

30. Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805, 2018.

31. Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J Invest Dermatol. 138:1221-1224, 2018.

32. Kawabata KC, Hayashi Y, Inoue D, Meguro H, Sakurai H, Fukuyama T, Tanaka Y, Asada S, Fukushima T, Nagase R, Takeda R, Harada Y, Kitaura J, Goyama S, Harada H, Aburatani H, Kitamura T: High expression of ABCG2 induced by EZH2 disruption plays pivotal roles in MDS pathogenesis. Leukemia. 32:419-428, 2018.

33. Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 7:4298, 2017.

34. Honjo A, Nakano N, Yamazaki S, Hara M, Uchida K, Kitaura J, Nishiyama C, Yagita H, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia. J Allergy Clin Immunol. 139:987-996, 2017.

35. Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J: Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 292: 2924-2932, 2017.

36. Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J: Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65: 777-87, 2016.

37. Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y, Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S, Fukuyama T, Tanaka Y, Ono R, Goyama S, Nosaka T, Kitaura J, Inoue D: Novel working hypothesis for pathogenesis of hematological malignancies: Combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). J Biochem. 159: 17-25, 2016.

38. Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Lamine Hafirassou M, Kitaura J, Ramdasi R, Schwartz O, Amara A: The phosphatidylserine and phosphatidylethanolamine receptor CD300a binds dengue virus and enhances infection. J Virol. 90: 92-102, 2015.

39. Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, Kitaura J, Ohtsuka Y, Okumura K, Ogawa H, Shimizu T: The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells. J Immunol. 195: 3427-3435, 2015.

40. Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T: A C-terminal mutant of C/EBP (C/EBPa-Cm) down-regulates the Csf1r, a potent accelerator in the progression of AML with C/EBPa-Cm. Exp Hematol. 43: 300-308, 2015.

41. Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T: SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS. Leukemia. 29: 847-857 2015.

42. Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcRI-mediated mast cell activation. J Allergy Clin Immunol. 133: 270-273, 2014.

43. Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T: A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4: 4012, 2014.

44. Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T: Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42: 369-379, 2014.

45. Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T: Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123: 3932-3942, 2014.

46. Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, Enomoto Y, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nagase R, Horikawa S, Hayashi Y, Saika M, Fukuyama T, Izawa K, Oki T, Nakahara F, Kitaura J. The molecular basis of myeloid malignancies. Proc Jpn Acad Ser B Phys Biol Sci. 90, 389-404, 2014.

47. Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J. Human CD300C Delivers an Fc Receptor-γ-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition. J Biol Chem. 288: 7662-7675, 2013.

48. Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M: The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model. Blood. 121: 4142-4155, 2013.

49. Nishimura K, Oki T, Kitaura J, Kuninaka S, Saya H, Sakaue-Sawano A, Miyawaki A, Kitamura T: APCCDH1 targets MgcRacGAP for destruction in the late M phase. PLOS One. 8, e63001, 2013.

50. Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T: Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest. 123: 4627-4640, 2013.

51. Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J: The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37: 827-839, 2012.

52. Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J: A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis. J Immunol. 189, 1773-1779, 2012.

53. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K: PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 24: 613-623, 2012.

54. Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T: Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. Int J Hematol. 96: 638-648, 2012.

55. Enomoto Y, Kitaura J, Shimanuki M, Kato N, Nishimura K, Takahashi M, Nakakuma H, Kitamura T, Sonoki T: MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPα (C/EBPα-C(m))-induced myeloid leukemia. Int J Hematol. 96: 334-341, 2012.

56. Kashiwakura JC, Ando T, Matsumoto K, Kimura M, Kitaura J, Matho MH, Zajonc DM, Ozeki T, Ra C, MacDonald SM, Siraganian RP, Broide DH, Kawakami Y, Kawakami T: Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy. J Clin Invest. 122: 218-228, 2012.

57. Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, Kitamura T: Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis. Leukemia. 26: 1038-1045, 2012.

58. Nakamura M, Kitaura J, Enomoto Y, Lu Y, Nishimura K, Isobe M, Ozaki K, Komeno Y, Nakahara F, Oki T, Kume H, Homma Y, Kitamura T: Transforming growth factor-β-stimulated clone-22 is a negative-feedback regulator of Ras / Raf signaling: Implications for tumorigenesis. Cancer Sci. 103: 26-33, 2012.

59. Shibata-Minoshima F, Oki T, Doki N, Nakahara F, Kageyama S, Kitaura J, Fukuoka J, Kitamura T: Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning. Int J Oncol. 40: 93-98, 2012.

60. Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T: Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int J Hematol. 95: 167-175, 2012.

61. Enomoto Y, Kitaura J, Hatakeyama K, Watanuki J, Akasaka T, Kato N, Shimanuki M, Nishimura K, Takahashi M, Taniwaki M, Haferlach C, Siebert R, Dyer MJ, Asou N, Aburatani H, Nakakuma H, Kitamura T, Sonoki T: Eμ/miR-125b transgenic mice develop lethal B-cell malignancies. Leukemia. 25: 1849-1856, 2011.

62. Kato N, Kitaura J, Doki N, Komeno Y, Watanabe-Okochi N, Togami K, Nakahara, F, Oki T, Enomoto Y, Fukuchi Y, Nakajima H, Harada Y, Harada H, Kitamura T: Two types of C/EBP mutations play distinct but collaborative roles in leukemogenesis: Lessons from clinical data and BMT models. Blood. 117: 221-233, 2011.

63. Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takamatsu R, Kajikawa M, Takai T, Kitamura T, Kitaura J: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem. 285: 35274-35283, 2010.

64. Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207: 1501-1511, 2010.

65. Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T: AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model. Leukemia. 24: 1018-1024, 2010.

66. Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura, T, Nosaka T: Expression of ADAMTS4 in Ewing's sarcoma. Int J Oncol. 37: 569-581, 2010.

67. Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S: Hes1 immortalizes committed progenitors and plays a role in blastic crisis of chronic myelogenous leukemia. Blood. 115: 2872-2881, 2010.

68. Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J: Evidence that integrinIIb3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J Biol Chem. 284: 31463-31472, 2009.

69. Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol. 183: 925-936, 2009.

70. Watanabe-Okochi N, Oki T, Komeno Y, Kato N, Yuji K, Ono R, Harada Y, Harada H, Hayashi Y, Nakajima H, Nosaka T, Kitaura J, Kitamura T: Possible involvement of RasGRP4 in leukemogenesis. Int J Hematol. 89: 470-481, 2009.

71. Miyazaki K, Yamasaki N, Oda H, Kuwata T, Kanno Y, Miyazaki M, Komeno Y, Kitaura J, Honda Z, Warming S, Jenkins NA, Copeland NG, Kitamura T, Nakamura, Honda H: Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia. Blood. 113: 4702-4710, 2009.

72. Komeno Y, Kitaura J, Kitamura T: Molecular bases of myelodysplastic　syndromes:　lessons from animal models. J Cell Physiol. 219: 529-534, 2009.

2009-2023年度　和文総説

1. 貝谷綾子、伊沢久未、井出拓磨、前原明絵、安藤智暁、北浦次郎: FcRIの制御機構（解説）、臨床免疫・アレルギー科。79：　300－306、2023。
2. 安東泰希、前原明絵、田村直人、北浦次郎：自己炎症性疾患における原因遺伝子解析、リウマチ科。68：371‐378、2022。
3. 中野信浩、米山俊之、北浦次郎：経口免疫療法による食物アレルギー症状の発生抑制のメカニズム、アロスエルゴン。2：729‐735、2022。
4. 北浦次郎、伊沢久未、貝谷綾子：＜アレルギー研究の展望＞ペア型免疫受容体とアレルギー疾患、アレルギーの臨床。42：15-19、2022。
5. 北浦次郎：IgEの生物学的役割、アロスエルゴン。1：122-124、2021。
6. 伊沢久未、貝谷綾子、北浦次郎：アレルギー疾患と抑制化受容体(特集:抑制化受容体と免疫応答)、炎症と免疫。29：13-18、2021。
7. 貝谷綾子、伊沢久未、内田志野、亀井杏菜、前原明絵、安藤智暁、北浦次郎: CD300f分子とアレルギー（解説）、臨床免疫・アレルギー科。75：218-225、2021
8. 内田志野、伊沢久未、安藤智暁、貝谷綾子、北浦次郎：CD300は食物アレルギーの治療標的となりうる。臨床免疫・アレルギー科。74：398-405、2020。
9. 貝谷綾子、高森絢子、安藤智暁、伊沢久未、北浦次郎：薬剤による偽アレルギーにおけるCD300fの役割について。臨床免疫・アレルギー科。72：122-128、2019。
10. 伊沢久未、奥村康、北浦次郎：抑制型免疫受容体CD300fとセラミド＜セラミド研究の新展開～基礎から応用へ～＞、セラミド研究会、食品化学新聞社。118-124、2019。
11. 北浦次郎、免疫とは何か？＜連載（免疫を知る）第１回＞、保健の科学。61：63-68、2019。
12. 貝谷綾子、前原明絵、高森綾子、伊沢久未、北浦次郎：セラミドと皮膚アレルギー・炎症。臨床免疫・アレルギー科。69：576-582、2018。
13. 伊沢久未、前原明絵、貝谷綾子、高森綾子、北浦次郎：敗血症性腹膜炎におけるCD300fとセラミドの役割。臨床免疫・アレルギー科。69：250-256、2018。
14. 前原秋絵、北浦次郎：LMIR3のアレルギーに対するブレーキメカニズムと今後の応用。COSMETIC STAGE。11：53-57、2017。
15. 北浦次郎：古くて新しいIgE（IgEをめぐる諸問題　アップデート）。アレルギー・免疫。23：1615-1619、2016。
16. 伊沢久未、貝谷綾子、前原明絵、北浦次郎：マスト細胞およびIgE依存性のアナフィラキシーを制御する受容体について。臨床免疫・アレルギー科。66：571-575、2016。
17. 松川敏大、北村俊雄、北浦次郎：LMIR3/CD300fによる実験的腸炎の制御：LMIR3とセラミドの結合はATPによる腸管マスト細胞の活性化を抑制する。臨床免疫・アレルギー科。64：374-379、2015。
18. 北浦次郎、北村俊雄、奥村康、伊沢久未：アトピー性皮膚炎におけるセラミドとLMIR3。臨床免疫・アレルギー科。63：151-155、2015。
19. 北浦次郎、伊沢久未、北村俊雄：LMIR3によるマスト細胞活性化の制御とアレルギー炎症の抑制。炎症と免疫。22：90-93、2014。　
20. 北浦次郎、伊沢久未、高橋まり子、北村俊雄：CD300群によるマスト細胞の活性化制御。臨床免疫・アレルギー科。61：384-390、2014。　
21. Kitamura T, Inoue D, Nakahara F, Okochi N, Kato N, Togami K, Uchida T, Kagiyama Y, Kawabata KC, Nagase R, Horikawa S, Hayashi K, Saika M, Izawa K, Oki T, Chiba S, Harada Y, Harada H, Kitaura J: Molecular basis of hematological malignancies. Rinsho Ketsueki. 55：1715-1723、2014。
22. 北浦次郎、伊沢久未、山西吉典、北村俊雄：LMIRの機能とリガンド。臨床免疫・アレルギー科。59：259-264、2013。
23. 北浦次郎、山西吉典、北村俊雄：CD300b/LMIR5と炎症。医学のあゆみ。245：229-233、2013。
24. 北浦次郎、伊沢久未、北村俊雄：LMIR3(CD300f)によるマスト細胞活性化の抑制。臨床免疫・アレルギー科。160：478-485、2013。
25. Watanabe-Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, Satoh Y, Shinohara A, Tsuruta T, Masuda A, Yokota H, Yatomi Y, Takahashi K, Kitaura J, Kitamura T, Kurokawa M: The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model. Rinsho Ketsueki. 54：749-758、2013。
26. Kitaura J, Izawa K, Kitamura T: An inhibitory receptor LMIR3/CD300f recognizes ceramide. Seikagaku. 85：1071-1075、2013。
27. 山西吉典、北浦次郎、北村俊雄: LMIR5のリガンドTIM1同定:LMIR5-TIM1の結合は腎虚血再還流障害を増悪させる。感染・炎症・免疫。41：321-323、2012。
28. 北浦次郎、伊沢久未、山西吉典、榎本豊、北村俊雄：CD300/LMIRファミリーとマスト細胞。臨床免疫・アレルギー科。58：190-196、2012。
29. 北浦次郎、伊沢久未、北村俊雄：アレルギーとマスト細胞＜抑制型レセプターLMIR3について＞。アレルギーの臨床。32：28-32、2012。
30. Kitamura T, Watanabe-Okochi N, Inoue D, Togami K, Uchida T, Kagiyama Y, Kawabata K, Chiba S, Harada Y, Harada H, Kitaura J, Nakahara F: Molecular mechanisms underlying leukemic transformation of myelodysplastic syndromes (MDS) and chronic myelogenous leukemia (CML) Rinsho Ketsueki. 53：734-739、2012。
31. 伊沢久未、北浦次郎、北村俊雄: Leukocyte mono-Ig like receptor 3 (LMIR3)によるマスト細胞の活性化と抑制化。臨床免疫・アレルギー科。54：135-141、2010。
32. 伊沢久未、北浦次郎、北村俊雄: マスト細胞の活性化とLMIR3―抑制型レセプターであるLMIR3はマスト細胞においてFcRIと会合し、リポポリサッカライドによる反応を増強する―。臨床免疫・アレルギー科。53：321-328、2010。
33. 山西吉典、北浦次郎、北村俊雄: 活性型レセプターLMIR5によるマスト細胞の機能制御-マウスおよびヒトLMIR5の相違。臨床免疫・アレルギー科。52：40-48、 2009。

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北浦 次郎（キタウラ ジロウ）

北浦次郎（キタウラジロウ）