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研究業績詳細

岡田 保典(オカダ ヤスノリ)

研究テーマ 組織内微小環境因子代謝と疾患
研究業績(論文) 平成26年度
Mikami S., Oya M., Mizuno R., Kosaka T., Katsube K. I. and Okada Y.: Invasion and metastasis of renal cell carcinoma. Med Mol Morphol 47:63-67, 2014.

Yamashita S. and Okada Y.: Heat-induced antigen retrieval in conventionally processed epon-embedded specimens: procedures and mechanisms. J Hictochem Cytochem 62:584-597, 2014.

Yoshioka K., Ishii K., Kuramoto T., Nagai S., Funao H., Ishihama H., Shiono Y., Sasaki A., Aizawa M., Okada Y., Koyasu S., Toyama Y. and Matsumoto M.: A novel mouse model of soft-tissue infection using bioluminescence imaging allows noninvasive, real-time monitoring of bacterial growth. PLoS One 9(9): e106367, 2014.

Shimoda M., Principe S., Jackson H.W., Luga V., Fang H., Molyneux S.D., Shao Y.W., Aiken A., Waterhouse P.D., Karamboulas C., Hess F.M., Ohtsuka T., Okada Y., Ailles L., Ludwig A., Wrana J.L., Kislinger T. and Kohkha R.: Loss of the TIMP gene family is sufficient for the acquisition of the CAF-like cell state. Nat Cell Biol 16: 889-901, 2014.


平成27年度
Mikami S., Mizuno R., Kosaka T., Saya H., Oya M. and Okada Y.: Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas. Int J Cancer 136:1504-1514, 2015.

Chijiiwa M., Mochizuki S., Kimura T., Abe H., Tanaka Y., Fujii Y., Shimizu H., Enomoto H., Toyama Y. and Okada Y.: CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity. Arthritis Rheum 67:1557-1567, 2015.

Kuroda A., Tasaka S., Yagi K., Mochimaru T., Tani T., Namkoog H., Tanaka K., Suzuki Y., Hatano M., Hasegawa N., Okada Y. and Betuyaku T.: A case of disseminated cryptococcal infection and concurrent lung tuberculosis in a patient under steroid therapy for interstitial pneumonia. Case Rep Pulmol, 2015. Article ID358926, 6 pages; http://dx.doi.org/10.1155/2015/358926.

Anzai A., Shimoda M., Endo J., Kohno T., Katsumata ., Matsuhashi T., Yamamoto T., Ito K., Yan X., Shirakawa K., Shimizu-Hirota R., Yamada Y., Ueha S., Shinmura K., Okada Y., Fukuda K. and Sano M.: Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture. Circ Res 116:612-623, 2015. DOI: 10.1161/CIRCRESAHA.116.304918.

Ishida M., Mikami S., Shinojima T., Kosaka T., Mizuno R., Kikuchi E., Miyajima A., Okada Y. and Oya M.: Activation of aryl hydrocarbon receptor promotes invasion of clear cell renal cell carcinoma and is associated with poor prognosis and cigarette smoke. Int J Cancer 137:299-310, 2015.

Mizuno S., Yoda M., Shimoda M., Tohmonda T., Okada Y., Toyama Y., Takeda S., Nakamura M., Matumoto M. and Horiuchi K.: A disintegrin and metalloprotease 10 is indispensable for maintenance of the muscle satellite cell pool. J Biol Chem 290:28456-28464, 2015. DOI:10.1074/jbc.M115.653477.

Nagaoka A., Yoshida H., Nakamura S., Morikawa T., Kawabata K., Kobayashi M., Sakai S., Takahashi Y., Okada Y. and Inoue S.: Regulation of hyaluronan (HA) metabolism mediated by HYBID (Hyaluronan binding protein involved in HA depolymerization, KIAA1199) and HA synthases in growth factor-stimulated fibroblasts. J Biol Chem 290:30910-30923, 2015. DOI:10.1074/jbc.M115.673566.

三上修治、水野隆一、小坂威雄、大家基嗣、岡田保典:腎細胞癌の進展の分子機構。細胞 47:43-46, 2015.

平成28年度
Shiraishi A., Mochizuki S., Miyakoshi A., Kojoh K. and Okada Y.: Development of human antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2). Biochem Biophys Res Commun 469:62-69, 2016.

Nanjo S., Ebi H., Arai S., Takeuchi S., Yamada T., Mochizuki S., Okada Y., Nakada M. and Yano S.: High efficacy of third generation EGFR inhibitor AZD9291 in a leptomeningeal carcinomatosis model with EGFR-mutant lung cancer cells. Oncotarget 7:3847-3856, 2016. (doi: 10.18632/oncotarget.6758)

Chiba T., Soeno Y., Shirako Y., Sudo H., Yagishita H., Taya Y., Kawashiri S., Okada Y. and Imai K.: MALT1 inhibition of oral carcinoma cell invasion and ERK/MAPK activation. J Dent Res 95:446-452, 2016.

Ota M., Mochizuki S., Shimoda M., Abe H., Miyamae Y., Ishii K., Kimura H. and Okada Y.: ADAM23 is down-regulated in side population and suppresses lung metastasis of lung carcinoma cells. Cancer Sci 107:433-443, 2016.

Shimoda M., Horiuchi K., Sasaki A., Tsukamoto T., Okabayashi K., Hasegawa H., Kitagawa Y. and Okada Y.: Epithelial cell-derived a disintegrin and metalloproteinase-17 confers resistance to colonic inflammation through EGFR activation. EBioMedicine 5:114-124, 2016.

Hashimoto S., Mikami S., Sugino H., Yoshikawa A., Hashimoto A., Onodera Y., Furukawa S., Handa H., Oikawa T., Okada Y., Oya M. and Sabe H.: Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Nature Commun 7:10656, 2016. (doi:10.1038/ncomms10656)

Tanaka N., Kosaka T., Miyazaki Y., Mikami S., Niwa N., Otsuka Y., Minamishima Y. A., Mizuno R., Kikuchi E., Miyajima A., Sabe H., Okada Y., Suematsu M., Oya M. and Uhlén P.: Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation. JCI Insight 1(18):e83654, 2016. (doi:10.1172/jci.insight.83654)

Miyamae Y., Mochizuki S., Shimoda M., Ohara K., Abe H., Yamashita S., Kazuno S., Ohtsuka T., Ochiai H., Kitagawa Y. and Okada Y.: ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death. FEBS J 283:1574-1594, 2016.

岡田保典:変形性関節症における関節軟骨破壊と再生機構:現状と今後の展望。 Functional Food Res 12:1-9, 2016.

石島旨章、羽田晋之介、金子晴香、劉立足、木下真由子、有田均、塩澤淳、アニユワルジャン・ユスプ、青木孝子、高澤祐治、池田浩、岡田保典、 金子和夫:Kellgren-Lawrence分類からみた早期変形性膝関節症研究への期待と課題。Bone Joint Nerve 6:533-41, 2016.

羽田晋之介、石島旨章、金子晴香、劉立足、木下真由子、有田均、塩澤淳、アニユワルジャン・ユスプ、青木孝子、高澤祐治、池田浩、岡田保典、金子和夫:MRIを用いた早期変形性膝関節症の病態解析。Bone Joint Nerve 6:549-55, 2016.

石島旨章、金子晴香、羽田晋之介、劉 立足、アヌワル・ジャン・ユユプ、清村幸雄、木下真由子、有田 均、塩澤 淳、青木孝子、長尾雅史、高澤祐治、池田 浩、岡田保典、金子和夫:変形性関節症の疼痛と関連する病態。リウマチ科 56:632-640, 2016.

Ishijima M., Kaneko H., Hada S., Kinoshita M., Ishibashi M., Sadatsuki R., Liu L., Arita H., Shiozawa J., Yusup A., Saita Y., Takazawa Y., Ikeda H., Arikawa-Hirasawa E., Okada Y. and Kaneko K.: Sportology to prevent locomoticve syndrome. Juntendo Med J, 62 Supple 1: 44-49, 2016.

Funao H., Nagai S., Sasaki A., Hoshikawa T., Tsuji T., Okada Y., Koyasu S., Toyama Y., Nakamura M., Aizawa M., Matsumoto M. and Ishii K.: A novel hydroxyapatite film coated with ionic silver via inositol hexaphosphate chelation prevents implant-associated infection. Sci Rep 6:23238, 2016. (doi:10.1038/srep23238)

Ishijima M., Kaneko H., Hada S., Kinoshita M., Sadatsuki R., Liu L., Shimura Y., Arita H., Shiozawa J., Yusup A., Futami I., Sakamoto Y., Ishibashi M., Machida S., Naito H., Arikawa-Hirasawa E., Hamada C., Saita Y., Takazawa Y., Ikeda H., Okada Y. and Kaneko K.: Osteoarthritis as a cause of locomotive syndrome: Its influence on functional mobility and activities of daily living. Clinic Rev Bone Miner Metab, 14, 77-104, 2016.

Shiono Y., Ishii K., Nagai S., Kakinuma H., Sasaki A., Tsuji T., Okada Y., Koyasu S., Nakamura M., Toyama Y., Aizawa M. and Matsumoto M.: Delayed Propionibacterium acnes surgical site infections occur only in the presence of an implant. Sci Rep 6:32758, 2016. (doi: 10.1038/srep32758)

Mikami S., Oya M., Mizuno R., Kosaka T., Ishida M., Kuroda N., Nagashima Y., Katsube K. and Okada Y.: Recent advances in renal cell carcinoma from a pathological point of view. Pathol Int 66:481-490, 2016.

Rudnicka C., Mochizuki S., Okada Y., McLaughlin C., Leedman P. J., Stuart L., Epis M., Hoyne G., Boulos S., Johnson L., Schlaich M. and Matthews V.: Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer. Medicine 95:40 (e5085), 2016.

Sada K., Harigai M., Amano K., Atsumi T., Fujimoto S., Yuzawa Y., Takasaki Y., Banno S., Sugihara T., Kobayashi M., Usui J., Ymagata H., Homma S., Dobashi H., Tsuboi N., Ishizu A., Sugiyama H., Okada Y., Arimura Y., Matuo S. and Makino H.: Comparison of severity classification in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study. Mod Rheumatol 26:730-737, 2016.

平成29年度
Okada Y.: Proteinases and matrix degradation. In Kelley and Firestein's Textbook of Rheumatology. Ed. by Firestein G. S., Budd R. C., Gabriel S. E., McInnes I. B. and O’Dell J. R. 10th Edition, Elsevier Inc. Philadelphia. pp106-125, 2017.

Yoshino Y., Ishisaka M., Tsuruma K., Shimazawa M., Yoshida H., Inoue S., Shimoda M., Okada Y. and Hara H.: Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system. Neuroscience 347:1-10, 2017.

Shimoda M., Yoshida H., Mizuno S., Hirozane T., Horiuchi K., Yoshino Y., Hara H., Kanai Y., Inoue S., Ishijima M. and Okada Y.: Hyaluronan-binding protein involved in hyaluronan depolymerization controls endothelial ossification through hyaluronan metabolism. Am J Pathol 187:1162-1176, 2017.

Nanjo S., Arai S., Wang W., Takeuchi S., Yamada T., Hata A., Katakami N., Okada Y. and Yano S.: MET copy number gain is associated with gefitinib resistance in leptomeningeal carcinomatosis of EGFR-mutated lung cancer. Mol Cancer Ther 1-10, 2017. Doi:10.1158/1535-7163.MCT-16-0522

Ishizu A., Tomaru U., Masuda S., Sada K., Amano K., Harigai M., Kawaguchi Y., Arimura Y., Yamagata K., Ozaki S., Dobashi H., Homma S., Okada Y., Sugiyama H., Usui J., Tsuboi N., Matsuo S. and Makino H.: Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis. Arthritis Res Ther 19 (1):117, 2017. (DOI: 10.1186/s13075-017-1328-7)

Mikami S., Oya M., Kosaka T., Mizuno R., Miyazaki Y., Sato Y. and Okada Y.: Increzsed vasohibin-1 expression is associated with metastasis and poor prognosis of renal cell carcinoma patients. Lab Invest 97:854-862, 2017.

Hada S., Ishijima M., Kaneko H., Kinoshita M., Liu L., Sadatusuki R., Futami I., Yusup A., Takamura T., Arita H., Shiozawa J., Aoki T., Takazawa Y., Ikeda H., Aoki S., Kurosawa H., Okada Y. and Kaneko K.: Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in the patients with eraly-stage knee osteoarthritis. Arthritis Res Ther 19:201, 2017. DOI 10.1186/s13075-017-1411-0

Daimon T., Kosaka T., Kikuchi E., Mikami S., Miyazaki Y., Hashimoto A., Hashimoto S., Mizuno R., Miyajima A., Okada Y., Sabe M. and Oya M.: Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma. Urol Oncol 35(9):543.e17-543.e24. 2017. Doi: 10.1016/j.urolonc.2017.04.008.

Okada Y.: ADAM28 in cancer cell proliferation and progression. Juntendo Med J 63:322-325, 2017.

平成30年度
Shimoda M., Ota M. and Okada Y.: Isolation of cancer stem cells by side population method. Methods Mol Biol 1692:49-59, 2018. DOI: 10.1007/978-1-4939-7401-6_5.

Ueno M., Shiomi T., Mochizuki S., Chijiiwa M., Shimoda M., Kanai Y., Kataoka F., Hirasawa A., Susumu N., Aoki D. and Okada Y.: ADAM9 is over-expressed in human clear cell carcinomas and suppresses cisplatin-induced cell death. Cancer Sci 109:471-482, 2018. DOI: 10.1111/cas.13469

Shimizu H., Shimoda M., Mochizuki S., Miyamae Y., Abe H., Chijiiiwa M., Yoshida H., Siozawa J., Ishijiima M., Kaneko K., Kanaji A., Nakamura M., Toyama Y. and Okada Y.: Hyaluronan-binding protein involved in hyaluronan depolymerization is up-regulated and involved in hyluronan degradation in human osteoarthritic cartilage. Am J Pathol 188:2109-2119, 2018.

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