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研究業績詳細

伊沢久未（イザワクミ）

研究テーマ	アレルギー・炎症性疾患の制御機構
研究業績（論文）	2009-2023年度英文原著・総説 1. Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K: TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 2023 (in press). 2. Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, Maehara A, Kojima M, Yamamoto R, Wang H, Nagamine M, Maeda K, Uchida K, Nakano N, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Kitaura J: Staphylococcus aureus d-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 14: 1173069, 2023. 3. Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J: The protective role of conjunctival goblet cell mucin sialylation. Nat Commun. 14: 1417, 2023 4. Kamei A, Izawa K, Ando T, Kaitani A, Yamamoto R, Maehara A, Ide T, Yamada H, Kojima M, Wang H, Tokushige K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper. Front Immunol. 13: 945222, 2022. 5. Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K: Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling. J Immunol. 207: 3098-3106, 2021. 6. Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J: Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice. Ocul Surf. 22: 153-162, 2021. 7. Yasudo H, Ando T, Maehara A, Ando T, Izawa K, Tanabe A, Kaitani A, Nomura S, Seki M, Yoshida K, Oda H, Okamoto Y, Wang H, Kamei A, Kojima M, Kimura M, Uchida K, Nakano N, Kaneko J, Ebihara N, Hasegawa K, Shimizu T, Takita J, Ogawa H, Okumura K, Ogawa S, Tamura N, Kitaura J: A Possible Association Between a Nucleotide-Binding Domain LRR-Containing Protein Family PYD-Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis. Hepatology. 74: 2296-2299, 2021. 8. Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14: 640-651, 2021. 9. Yoneyama T, Nakano N, Hara M, Yamada H, Izawa K, Uchida K, Kaitani A, Ando T, Kitaura J, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J Allergy Clin Immunol. 147: 1063-1076, 2021. 10. Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J: CD300f is a potential therapeutic target for the treatment of food allergy. Allergy. 75: 471-474, 2020. 11. Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J: Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain. J Invest Dermatol. 140: 710-713, 2020. 12. Takahashi M, Izawa K, Urai M, Yamanishi Y, Maehara A, Isobe M, Matsukawa T, Kaitani A, Takamori A, Uchida S, Yamada H, Nagamine M, Ando T, Shimizu T, Ogawa H, Okumura K, Kinjo Y, Kitamura T, Kitaura J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12: 564, 2019. 13. Takamori A, Izawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation. J Allergy Clin Immunol. 143: 1231-1235, 2019. 14. Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S: Receptor destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis. J Biol Chem. 294: 6659-6669, 2019. 15. Ueno K, Urai M, Izawa K, Otani Y, Yanagihara N, Kataoka M, Takatsuka S, Abe M, Hasegawa H, Shimizu K, Kitamura T, Kitaura J, Miyazaki Y, Kinjo Y: Mouse LMIR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils. Sci Rep. 8: 17406, 2018. 16. Kaitani A, Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: 　Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8:8259, 2018. 17. Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805, 2018. 18. Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J Invest Dermatol. 138:1221-1224, 2018. 19. Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 7:4298, 2017. 20. Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J: Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 292: 2924-2932, 2017. 21. Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J: Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65: 777-87, 2016. 22. Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y, Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S, Fukuyama T, Tanaka Y, Ono R, Goyama S, Nosaka T, Kitaura J, Inoue D: Novel working hypothesis for pathogenesis of hematological malignancies: Combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). J Biochem. 159: 17-25, 2016. 23. Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T: A C-terminal mutant of C/EBPα (C/EBPa-Cm) down-regulates the Csf1r, a potent accelerator in the progression of AML with C/EBPa-Cm. Exp Hematol. 43: 300-308, 2015. 24. Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. J Allergy Clin Immunol. 133: 270-273, 2014. 25. Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T: A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4: 4012, 2014. 26. Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T: Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42: 369-379, 2014. 27. Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T: Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123: 3932-3942, 2014. 28. Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, Enomoto Y, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nagase R, Horikawa S, Hayashi Y, Saika M, Fukuyama T, Izawa K, Oki T, Nakahara F, Kitaura J. The molecular basis of myeloid malignancies. Proc Jpn Acad Ser B Phys Biol Sci. 90, 389-404, 2014. 29. Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J. Human CD300C Delivers an Fc Receptor-γ-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition. J Biol Chem. 288: 7662-7675, 2013. 30. Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T: Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest. 123: 4627-4640, 2013. 31. Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J: The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37: 827-839, 2012. 32. Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J: A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis. J Immunol. 189, 1773-1779, 2012. 33. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K: PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 24: 613-623, 2012. 34. Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T: Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. Int J Hematol. 96: 638-648, 2012. 35. Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T: Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int J Hematol. 95: 167-175, 2012. 36. Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takamatsu R, Kajikawa M, Takai T, Kitamura T, Kitaura J: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem. 285: 35274-35283, 2010. 37. Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207: 1501-1511, 2010. 38. Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura, T, Nosaka T: Expression of ADAMTS4 in Ewing's sarcoma. Int J Oncol. 37: 569-581, 2010. 39. Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J: Evidence that integrinαIIbβ3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J Biol Chem. 284: 31463-31472, 2009. 40. Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol. 183: 925-936, 2009. 2009-2023年度　和文総説 1. 貝谷綾子、伊沢久未、井出拓磨、前原明絵、安藤智暁、北浦次郎: FcεRIの制御機構（解説）、臨床免疫・アレルギー科。79：　300－306、2023。 2. 北浦次郎、伊沢久未、貝谷綾子：＜アレルギー研究の展望＞ペア型免疫受容体とアレルギー疾患、アレルギーの臨床。42：15-19、2022。 3. 伊沢久未、貝谷綾子、北浦次郎：アレルギー疾患と抑制化受容体(特集:抑制化受容体と免疫応答)、炎症と免疫。29：13-18、2021。 4. 貝谷綾子、伊沢久未、内田志野、亀井杏菜、前原明絵、安藤智暁、北浦次郎: CD300f分子とアレルギー（解説）、臨床免疫・アレルギー科。75：218-225、2021 5. 内田志野、伊沢久未、安藤智暁、貝谷綾子、北浦次郎：CD300は食物アレルギーの治療標的となりうる。臨床免疫・アレルギー科。74：398-405、2020。 6. 貝谷綾子、高森絢子、安藤智暁、伊沢久未、北浦次郎：薬剤による偽アレルギーにおけるCD300fの役割について。臨床免疫・アレルギー科。72：122-128、2019。 7. 伊沢久未、奥村康、北浦次郎：抑制型免疫受容体CD300fとセラミド＜セラミド研究の新展開～基礎から応用へ～＞、セラミド研究会、食品化学新聞社。118-124、2019。 8. 貝谷綾子、前原明絵、高森綾子、伊沢久未、北浦次郎：セラミドと皮膚アレルギー・炎症。臨床免疫・アレルギー科。69：576-582、2018。 9. 伊沢久未、前原明絵、貝谷綾子、高森綾子、北浦次郎：敗血症性腹膜炎におけるCD300fとセラミドの役割。臨床免疫・アレルギー科。69：250-256、2018。 10. 伊沢久未、貝谷綾子、前原明絵、北浦次郎：マスト細胞およびIgE依存性のアナフィラキシーを制御する受容体について。臨床免疫・アレルギー科。66：571-575、2016。 11. 北浦次郎、北村俊雄、奥村康、伊沢久未：アトピー性皮膚炎におけるセラミドとLMIR3。臨床免疫・アレルギー科。63：151-155、2015。 12. 北浦次郎、伊沢久未、北村俊雄：LMIR3によるマスト細胞活性化の制御とアレルギー炎症の抑制。炎症と免疫。22：90-93、2014。　 13. 北浦次郎、伊沢久未、高橋まり子、北村俊雄：CD300群によるマスト細胞の活性化制御。臨床免疫・アレルギー科。61：384-390、2014。　 14. Kitamura T, Inoue D, Nakahara F, Okochi N, Kato N, Togami K, Uchida T, Kagiyama Y, Kawabata KC, Nagase R, Horikawa S, Hayashi K, Saika M, Izawa K, Oki T, Chiba S, Harada Y, Harada H, Kitaura J: Molecular basis of hematological malignancies. Rinsho Ketsueki. 55：1715-1723、2014。 15. 北浦次郎、伊沢久未、山西吉典、北村俊雄：LMIRの機能とリガンド。臨床免疫・アレルギー科。59：259-264、2013。 16. 北浦次郎、伊沢久未、北村俊雄：LMIR3(CD300f)によるマスト細胞活性化の抑制。臨床免疫・アレルギー科。160：478-485、2013。 17. Kitaura J, Izawa K, Kitamura T: An inhibitory receptor LMIR3/CD300f recognizes ceramide. Seikagaku. 85：1071-1075、2013。 18. 北浦次郎、伊沢久未、山西吉典、榎本豊、北村俊雄：CD300/LMIRファミリーとマスト細胞。臨床免疫・アレルギー科。58：190-196、2012。 19. 北浦次郎、伊沢久未、北村俊雄：アレルギーとマスト細胞＜抑制型レセプターLMIR3について＞。アレルギーの臨床。32：28-32、2012。 20. 伊沢久未、北浦次郎、北村俊雄: Leukocyte mono-Ig like receptor 3 (LMIR3)によるマスト細胞の活性化と抑制化。臨床免疫・アレルギー科。54：135-141、2010。 21. 伊沢久未、北浦次郎、北村俊雄: マスト細胞の活性化とLMIR3―抑制型レセプターであるLMIR3はマスト細胞においてFcRIと会合し、リポポリサッカライドによる反応を増強する―。臨床免疫・アレルギー科。53：321-328、2010。

研究テーマ

アレルギー・炎症性疾患の制御機構

研究業績（論文）

2009-2023年度英文原著・総説

1. Shibata T, Sato R, Taoka M, Saitoh SI, Komine M, Yamaguchi K, Goyama S, Motoi Y, Kitaura J, Izawa K, Yamauchi Y, Tsukamoto Y, Ichinohe T, Fujita E, Hiranuma R, Fukui R, Furukawa Y, Kitamura T, Takai T, Tojo A, Ohtsuki M, Ohto U, Shimizu T, Ozawa M, Yoshida N, Isobe T, Latz E, Mukai K, Taguchi T, Hemmi H, Akira S, Miyake K: TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. J Exp Med. 2023 (in press).

2. Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, Maehara A, Kojima M, Yamamoto R, Wang H, Nagamine M, Maeda K, Uchida K, Nakano N, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Kitaura J: Staphylococcus aureus d-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 14: 1173069, 2023.

3. Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J: The protective role of conjunctival goblet cell mucin sialylation. Nat Commun. 14: 1417, 2023

4. Kamei A, Izawa K, Ando T, Kaitani A, Yamamoto R, Maehara A, Ide T, Yamada H, Kojima M, Wang H, Tokushige K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper. Front Immunol. 13: 945222, 2022.

5. Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K: Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling. J Immunol. 207: 3098-3106, 2021.

6. Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J: Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice. Ocul Surf. 22: 153-162, 2021.

7. Yasudo H, Ando T, Maehara A, Ando T, Izawa K, Tanabe A, Kaitani A, Nomura S, Seki M, Yoshida K, Oda H, Okamoto Y, Wang H, Kamei A, Kojima M, Kimura M, Uchida K, Nakano N, Kaneko J, Ebihara N, Hasegawa K, Shimizu T, Takita J, Ogawa H, Okumura K, Ogawa S, Tamura N, Kitaura J: A Possible Association Between a Nucleotide-Binding Domain LRR-Containing Protein Family PYD-Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis. Hepatology. 74: 2296-2299, 2021.

8. Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14: 640-651, 2021.

9. Yoneyama T, Nakano N, Hara M, Yamada H, Izawa K, Uchida K, Kaitani A, Ando T, Kitaura J, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J Allergy Clin Immunol. 147: 1063-1076, 2021.

10. Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J: CD300f is a potential therapeutic target for the treatment of food allergy. Allergy. 75: 471-474, 2020.

11. Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J: Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain. J Invest Dermatol. 140: 710-713, 2020.

12. Takahashi M, Izawa K, Urai M, Yamanishi Y, Maehara A, Isobe M, Matsukawa T, Kaitani A, Takamori A, Uchida S, Yamada H, Nagamine M, Ando T, Shimizu T, Ogawa H, Okumura K, Kinjo Y, Kitamura T, Kitaura J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12: 564, 2019.

13. Takamori A, Izawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation. J Allergy Clin Immunol. 143: 1231-1235, 2019.

14. Yamazaki T, Inui M, Hiemori K, Tomono S, Itoh M, Ichimonji I, Nakashima A, Takagi H, Biswas M, Izawa K, Kitaura J, Imai T, Sugiura N, Tateno H, Akashi-Takamura S: Receptor destroying enzyme (RDE) from Vibrio cholerae modulates IgE activity and reduces the initiation of anaphylaxis. J Biol Chem. 294: 6659-6669, 2019.

15. Ueno K, Urai M, Izawa K, Otani Y, Yanagihara N, Kataoka M, Takatsuka S, Abe M, Hasegawa H, Shimizu K, Kitamura T, Kitaura J, Miyazaki Y, Kinjo Y: Mouse LMIR3/CD300f is a negative regulator of the antimicrobial activity of neutrophils. Sci Rep. 8: 17406, 2018.

16. Kaitani A, Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: 　Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8:8259, 2018.

17. Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805, 2018.

18. Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J Invest Dermatol. 138:1221-1224, 2018.

19. Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 7:4298, 2017.

20. Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J: Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 292: 2924-2932, 2017.

21. Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J: Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65: 777-87, 2016.

22. Kitamura T, Watanabe-Okochi N, Enomoto Y, Nakahara F, Oki T, Komeno Y, Kato N, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nishimura K, Hayashi Y, Nagase R, Saika M, Fukushima T, Asada S, Fujino T, Izawa Y, Horikawa S, Fukuyama T, Tanaka Y, Ono R, Goyama S, Nosaka T, Kitaura J, Inoue D: Novel working hypothesis for pathogenesis of hematological malignancies: Combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). J Biochem. 159: 17-25, 2016.

23. Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T: A C-terminal mutant of C/EBPα (C/EBPa-Cm) down-regulates the Csf1r, a potent accelerator in the progression of AML with C/EBPa-Cm. Exp Hematol. 43: 300-308, 2015.

24. Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. J Allergy Clin Immunol. 133: 270-273, 2014.

25. Oki T, Nishimura K, Kitaura J, Togami K, Maehara A, Izawa K, Sakaue-Sawano A, Niida A, Miyano S, Aburatani H, Kiyonari H, Miyawaki A, Kitamura T: A novel cell-cycle-indicator, mVenus-p27K-, identifies quiescent cells and visualizes G0-G1 transition. Sci Rep. 4: 4012, 2014.

26. Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T: Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. Exp Hematol. 42: 369-379, 2014.

27. Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T: Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. Blood. 123: 3932-3942, 2014.

28. Kitamura T, Inoue D, Okochi-Watanabe N, Kato N, Komeno Y, Lu Y, Enomoto Y, Doki N, Uchida T, Kagiyama Y, Togami K, Kawabata KC, Nagase R, Horikawa S, Hayashi Y, Saika M, Fukuyama T, Izawa K, Oki T, Nakahara F, Kitaura J. The molecular basis of myeloid malignancies. Proc Jpn Acad Ser B Phys Biol Sci. 90, 389-404, 2014.

29. Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J. Human CD300C Delivers an Fc Receptor-γ-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition. J Biol Chem. 288: 7662-7675, 2013.

30. Inoue D, Kitaura J, Togami K, Nishimura K, Enomoto Y, Uchida T, Kagiyama Y, Kawabata KC, Nakahara F, Izawa K, Oki T, Maehara A, Isobe M, Tsuchiya A, Harada Y, Harada H, Ochiya T, Aburatani H, Kimura H, Thol F, Heuser M, Levine RL, Abdel-Wahab O, Kitamura T: Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. J Clin Invest. 123: 4627-4640, 2013.

31. Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J: The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37: 827-839, 2012.

32. Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J: A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis. J Immunol. 189, 1773-1779, 2012.

33. Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K: PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells. Int Immunol. 24: 613-623, 2012.

34. Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T: Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. Int J Hematol. 96: 638-648, 2012.

35. Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Kato N, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T: Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int J Hematol. 95: 167-175, 2012.

36. Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takamatsu R, Kajikawa M, Takai T, Kitamura T, Kitaura J: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem. 285: 35274-35283, 2010.

37. Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207: 1501-1511, 2010.

38. Minobe K, Ono R, Matsumine A, Shibata-Minoshima F, Izawa K, Oki T, Kitaura J, Iino T, Takita J, Iwamoto S, Hori H, Komada Y, Uchida A, Hayashi Y, Kitamura, T, Nosaka T: Expression of ADAMTS4 in Ewing's sarcoma. Int J Oncol. 37: 569-581, 2010.

39. Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J: Evidence that integrinαIIbβ3-dependent interaction of mast cells with fibrinogen exacerbates chronic inflammation. J Biol Chem. 284: 31463-31472, 2009.

40. Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol. 183: 925-936, 2009.

2009-2023年度　和文総説

1. 貝谷綾子、伊沢久未、井出拓磨、前原明絵、安藤智暁、北浦次郎: FcεRIの制御機構（解説）、臨床免疫・アレルギー科。79：　300－306、2023。
2. 北浦次郎、伊沢久未、貝谷綾子：＜アレルギー研究の展望＞ペア型免疫受容体とアレルギー疾患、アレルギーの臨床。42：15-19、2022。
3. 伊沢久未、貝谷綾子、北浦次郎：アレルギー疾患と抑制化受容体(特集:抑制化受容体と免疫応答)、炎症と免疫。29：13-18、2021。
4. 貝谷綾子、伊沢久未、内田志野、亀井杏菜、前原明絵、安藤智暁、北浦次郎: CD300f分子とアレルギー（解説）、臨床免疫・アレルギー科。75：218-225、2021
5. 内田志野、伊沢久未、安藤智暁、貝谷綾子、北浦次郎：CD300は食物アレルギーの治療標的となりうる。臨床免疫・アレルギー科。74：398-405、2020。
6. 貝谷綾子、高森絢子、安藤智暁、伊沢久未、北浦次郎：薬剤による偽アレルギーにおけるCD300fの役割について。臨床免疫・アレルギー科。72：122-128、2019。
7. 伊沢久未、奥村康、北浦次郎：抑制型免疫受容体CD300fとセラミド＜セラミド研究の新展開～基礎から応用へ～＞、セラミド研究会、食品化学新聞社。118-124、2019。
8. 貝谷綾子、前原明絵、高森綾子、伊沢久未、北浦次郎：セラミドと皮膚アレルギー・炎症。臨床免疫・アレルギー科。69：576-582、2018。
9. 伊沢久未、前原明絵、貝谷綾子、高森綾子、北浦次郎：敗血症性腹膜炎におけるCD300fとセラミドの役割。臨床免疫・アレルギー科。69：250-256、2018。
10. 伊沢久未、貝谷綾子、前原明絵、北浦次郎：マスト細胞およびIgE依存性のアナフィラキシーを制御する受容体について。臨床免疫・アレルギー科。66：571-575、2016。
11. 北浦次郎、北村俊雄、奥村康、伊沢久未：アトピー性皮膚炎におけるセラミドとLMIR3。臨床免疫・アレルギー科。63：151-155、2015。
12. 北浦次郎、伊沢久未、北村俊雄：LMIR3によるマスト細胞活性化の制御とアレルギー炎症の抑制。炎症と免疫。22：90-93、2014。　
13. 北浦次郎、伊沢久未、高橋まり子、北村俊雄：CD300群によるマスト細胞の活性化制御。臨床免疫・アレルギー科。61：384-390、2014。　
14. Kitamura T, Inoue D, Nakahara F, Okochi N, Kato N, Togami K, Uchida T, Kagiyama Y, Kawabata KC, Nagase R, Horikawa S, Hayashi K, Saika M, Izawa K, Oki T, Chiba S, Harada Y, Harada H, Kitaura J: Molecular basis of hematological malignancies. Rinsho Ketsueki. 55：1715-1723、2014。
15. 北浦次郎、伊沢久未、山西吉典、北村俊雄：LMIRの機能とリガンド。臨床免疫・アレルギー科。59：259-264、2013。
16. 北浦次郎、伊沢久未、北村俊雄：LMIR3(CD300f)によるマスト細胞活性化の抑制。臨床免疫・アレルギー科。160：478-485、2013。
17. Kitaura J, Izawa K, Kitamura T: An inhibitory receptor LMIR3/CD300f recognizes ceramide. Seikagaku. 85：1071-1075、2013。
18. 北浦次郎、伊沢久未、山西吉典、榎本豊、北村俊雄：CD300/LMIRファミリーとマスト細胞。臨床免疫・アレルギー科。58：190-196、2012。
19. 北浦次郎、伊沢久未、北村俊雄：アレルギーとマスト細胞＜抑制型レセプターLMIR3について＞。アレルギーの臨床。32：28-32、2012。
20. 伊沢久未、北浦次郎、北村俊雄: Leukocyte mono-Ig like receptor 3 (LMIR3)によるマスト細胞の活性化と抑制化。臨床免疫・アレルギー科。54：135-141、2010。
21. 伊沢久未、北浦次郎、北村俊雄: マスト細胞の活性化とLMIR3―抑制型レセプターであるLMIR3はマスト細胞においてFcRIと会合し、リポポリサッカライドによる反応を増強する―。臨床免疫・アレルギー科。53：321-328、2010。

研究者

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伊沢 久未（イザワ クミ）

伊沢久未（イザワクミ）