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杉谷善信（スギタニヨシノブ）

研究テーマ	脳細胞多様性形成とその破綻による精神疾患及び小児脳腫瘍の発症機序の解明
研究業績（論文）	「原著論文」 1. Takeshima H, Ikemoto T, Nishi M, Nishiyama N, Shimuta M,Sugitani Y, Kuno J, Saito I, Saito H, Endo M, Iino M, Noda T: Generation and characterization of mutant mice lacking　ryanodine receptor type 3.　 J. Biol. Chem. 271: 19649-19652, 1996, IF:4.125/CI:172 2. Minowa O, Ikeda K, Sugitani Y, Oshima T, Nakai S, Katori Y, Suzuki M, Furukawa M, Kawase T, Zheng Y, Ogura M, Asada Y, Watanabe K, Yamanaka H, Gotoh S, Nishi-Takeshima M, Sugitmoto T, Kikuchi T, Takasaka T, Noda T: Altered cochlear fibrocytes in a mouse model of DFN3　nonsyndromic deafness. Science 285: 1408-1411, 1999, IF:41.058/CI:193 3. Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H,　Kobayashi E, Noda T, Hino O: A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by TSC2 mutation in mice. PNAS USA 98: 8762-8767, 2001, IF:9.661/CI:209 4. Hasegawa S, Sato T, Akazawa H, Okada H, Maeno A, Ito M,　Sugitani Y, Shibata H, Miyazaki Ji J, Katsuki M, Yamauchi Y, Yamamura Ki K, Katamine S, Noda T: Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. PNAS USA 99: 11211-11216, 2002, IF:9.661/CI:67 5. Owada Y, Takano H, Yamanaka H, Kobayashi H, Sugitani Y,　Tomioka Y, Suzuki I, Suzuki R, Terui T, Mizugaki M, Tagami H, Noda T, Kondo H: Altered water barrier function in epidermal-type fatty acid binding protein-deficient mice. J. Invest. Dermatol. 118: 430-435, 2002, IF:6.287/CI:53 6. Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S: Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J. Cell Biol. 156: 1099-1111, 2002, IF:7.955/CI:1295 7. Yao R, Ito C, Natsume Y, Sugitani Y, Yamanaka H, Kuretake S, Yanagida K, Sato A, Toshimori K, Noda T: Lack of acrosome formation in mice lacking a Golgi protein, GOPC. PNAS USA 99: 11211-11216, 2002, IF:9.661/CI:221 8. Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H, Mori K, Ogawa M, Noda T. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes & Dev. 16: 1760-1765, 2002, IF:9.413/CI:197 9. Nakai S, Sugitani Y, Sato H, Ito S, Miura Y, Ogawa M, Nishi M, Jishage K, Minowa O, Noda T: Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development 130: 4751-4759, 2003, IF:5.843/CI:109 10. Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T: PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development 133: 1389-1398, 2006, IF:5.843/CI:95 11. Kumada K, Yao R, Kawaguchi T, Karasawa M, Hoshikawa Y, Ichikawa K, Sugitani Y, Imoto I, Inazawa J, Sugawara M, Yanagida M, Noda T: The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J. Cell Biol. 72: 835-846, 2006, IF:7.955/CI:76 12. Owada Y, Abdelwahab SA, Kitanaka N, Sakagami H,Takano H, Sugitani Y, Sugawara M, Kawashima H, Kiso Y, Mobarakeh JI, Yanai K, Kaneko K, Sasaki H, Kato H, Saino-Saito S, Matsumoto N, Akaike N, Noda T, Kondo H: Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene. Eur. J. Neurosci. 24: 175-187, 2006, IF:2.941/CI:105 13. Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A,Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J., Kawano H., Kasai M: The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev. Biol. 331: 140-151, 2009, IF:2.944/CI:37 14. Mutai H, Nagashima R, Sugitani Y, Noda T, Fujii M, Matsunaga T: Expression of POU3f3/Brn-1 and its genomic methylation in developing auditory epithelium. Dev. Neurobiol. 69: 913-930, 2009, IF:2.972/CI:13 15. Massa F, Garbay S,Bouvier R, Sugitani Y, Noda T, Gubler MC, Heidet L, Pontoglio M, Fischer E: Hepatocyte nuclear factor 1b controls nephron tubular development. Development 140: 886-896, 2013, IF:5.843/CI:54 16. Yumoto T, Nakadate K, Nakamura Y, Sugitani Y, Sugitani-Yoshida R, Ueda S, Sakakibara S: Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors. PLoS One 8: e79895, 2013, IF:2.806/CI:4 17. Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Kurasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K: Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J. Clin. Invest. 124: 1598-1607, 2014, IF:12.784/CI:23 18. Kidokoro Y, Karasawa K, Minowa O, Sugitani Y. Noda T, Ikeda K, Kamiya K: Deficiency of Transcription Factor Brn4 Disrupts Cochlear Gap Junction Plaques in a Model of DFN3 Non-Syndromic Deafness. PLoS One 9: e108216, 2014, IF:2.806/CI:4 19. Izuta T, Kamiya K, Gotoh S, Sugitani Y, Suzuki M, Noda T, Minowa O, Ikeda K: Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness. Hum. Mol. Genet. 24: 3651-61, 2015, IF:5.340/CI:25 20.Hamano Y, Ito F, Suzuki O, Koura M, Matsuoka S, Kobayashi T, Sugitani Y, Wali N, Koyanagi A, Hino O, Suzuki S, Sugamata R, Yoshizawa H, Yumura W, Maruyama N, Kameoka Y, Noda Y, Hasegawa Y, Arai T, Suzuki K:Vasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice. Autoimmunity(in Press), 2019, IF:2.403 「和文総説」 1. 杉谷善信: 聴覚系・視覚系の発生・発達におけるPOU転写因子Brn3.1とBrn3.2の役割実験医学14: 2736-2737, 1996 2. 杉谷善信, 小川正晴, 野田哲生: 大脳新皮質の発生-細胞の運命決定・産生・移動・配置の諸機構蛋白質・核酸・酵素49: 247-54, 2004

研究テーマ

脳細胞多様性形成とその破綻による精神疾患及び小児脳腫瘍の発症機序の解明

研究業績（論文）

「原著論文」

1. Takeshima H, Ikemoto T, Nishi M, Nishiyama N, Shimuta M,Sugitani Y, Kuno J, Saito I, Saito H, Endo M, Iino M, Noda T: Generation and characterization of mutant mice lacking　ryanodine receptor type 3.　
J. Biol. Chem. 271: 19649-19652, 1996, IF:4.125/CI:172

2. Minowa O, Ikeda K, Sugitani Y, Oshima T, Nakai S, Katori Y, Suzuki M, Furukawa M, Kawase T, Zheng Y, Ogura M, Asada Y, Watanabe K, Yamanaka H, Gotoh S, Nishi-Takeshima M, Sugitmoto T, Kikuchi T, Takasaka T, Noda T: Altered cochlear fibrocytes in a mouse model of DFN3　nonsyndromic deafness.
Science 285: 1408-1411, 1999, IF:41.058/CI:193

3. Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H,　Kobayashi E, Noda T, Hino O: A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by TSC2 mutation in mice.
PNAS USA 98: 8762-8767, 2001, IF:9.661/CI:209

4. Hasegawa S, Sato T, Akazawa H, Okada H, Maeno A, Ito M,　Sugitani Y, Shibata H, Miyazaki Ji J, Katsuki M, Yamauchi Y, Yamamura Ki K, Katamine S, Noda T: Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene.
PNAS USA 99: 11211-11216, 2002, IF:9.661/CI:67

5. Owada Y, Takano H, Yamanaka H, Kobayashi H, Sugitani Y,　Tomioka Y, Suzuki I, Suzuki R, Terui T, Mizugaki M, Tagami H, Noda T, Kondo H: Altered water barrier function in epidermal-type fatty acid binding protein-deficient mice.
J. Invest. Dermatol. 118: 430-435, 2002, IF:6.287/CI:53

6. Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S: Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice.
J. Cell Biol. 156: 1099-1111, 2002, IF:7.955/CI:1295

7. Yao R, Ito C, Natsume Y, Sugitani Y, Yamanaka H, Kuretake S, Yanagida K, Sato A, Toshimori K, Noda T: Lack of acrosome formation in mice lacking a Golgi protein, GOPC.
PNAS USA 99: 11211-11216, 2002, IF:9.661/CI:221

8. Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H, Mori K, Ogawa M, Noda T. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.
Genes & Dev. 16: 1760-1765, 2002, IF:9.413/CI:197

9. Nakai S, Sugitani Y, Sato H, Ito S, Miura Y, Ogawa M, Nishi M, Jishage K, Minowa O, Noda T: Crucial roles of Brn1 in distal tubule formation and function in mouse kidney.
Development 130: 4751-4759, 2003, IF:5.843/CI:109

10. Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T: PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.
Development 133: 1389-1398, 2006, IF:5.843/CI:95

11. Kumada K, Yao R, Kawaguchi T, Karasawa M, Hoshikawa Y, Ichikawa K, Sugitani Y, Imoto I, Inazawa J, Sugawara M, Yanagida M, Noda T: The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase.
J. Cell Biol. 72: 835-846, 2006, IF:7.955/CI:76

12. Owada Y, Abdelwahab SA, Kitanaka N, Sakagami H,Takano H, Sugitani Y, Sugawara M, Kawashima H, Kiso Y, Mobarakeh JI, Yanai K, Kaneko K, Sasaki H, Kato H, Saino-Saito S, Matsumoto N, Akaike N, Noda T, Kondo H: Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene.
Eur. J. Neurosci. 24: 175-187, 2006, IF:2.941/CI:105

13. Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A,Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J., Kawano H., Kasai M: The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex.
Dev. Biol. 331: 140-151, 2009, IF:2.944/CI:37

14. Mutai H, Nagashima R, Sugitani Y, Noda T, Fujii M, Matsunaga T: Expression of POU3f3/Brn-1 and its genomic methylation in developing auditory epithelium.
Dev. Neurobiol. 69: 913-930, 2009, IF:2.972/CI:13

15. Massa F, Garbay S,Bouvier R, Sugitani Y, Noda T, Gubler MC, Heidet L, Pontoglio M, Fischer E: Hepatocyte nuclear factor 1b controls nephron tubular development.
Development 140: 886-896, 2013, IF:5.843/CI:54

16. Yumoto T, Nakadate K, Nakamura Y, Sugitani Y, Sugitani-Yoshida R, Ueda S, Sakakibara S: Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors.
PLoS One 8: e79895, 2013, IF:2.806/CI:4

17. Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Kurasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K: Assembly of the cochlear gap junction macromolecular complex requires connexin 26.
J. Clin. Invest. 124: 1598-1607, 2014, IF:12.784/CI:23

18. Kidokoro Y, Karasawa K, Minowa O, Sugitani Y. Noda T, Ikeda K, Kamiya K: Deficiency of Transcription Factor Brn4 Disrupts Cochlear Gap Junction Plaques in a Model of DFN3 Non-Syndromic Deafness.
PLoS One 9: e108216, 2014, IF:2.806/CI:4

19. Izuta T, Kamiya K, Gotoh S, Sugitani Y, Suzuki M, Noda T, Minowa O, Ikeda K: Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness.
Hum. Mol. Genet. 24: 3651-61, 2015, IF:5.340/CI:25

20.Hamano Y, Ito F, Suzuki O, Koura M, Matsuoka S, Kobayashi T, Sugitani Y, Wali N, Koyanagi A, Hino O, Suzuki S, Sugamata R, Yoshizawa H, Yumura W, Maruyama N, Kameoka Y, Noda Y, Hasegawa Y, Arai T, Suzuki K:Vasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice.
Autoimmunity(in Press), 2019, IF:2.403

「和文総説」

1. 杉谷善信:
聴覚系・視覚系の発生・発達におけるPOU転写因子Brn3.1とBrn3.2の役割
実験医学14: 2736-2737, 1996

2. 杉谷善信, 小川正晴, 野田哲生:
大脳新皮質の発生-細胞の運命決定・産生・移動・配置の諸機構
蛋白質・核酸・酵素49: 247-54, 2004

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研究業績詳細

杉谷 善信（スギタニ ヨシノブ）

杉谷善信（スギタニヨシノブ）