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研究業績詳細

野中 里紗(ノナカ リサ)

研究テーマ 細胞外マトリックスに着目した細胞機能解析、iPS細胞を用いた神経変性疾患の解析
研究業績(論文) 1. Mutations in CHCHD2 cause α-synuclein aggregation.
Ikeda A, Nishioka K, Meng H, Takanashi M, Hasegawa I, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa K-I, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori, N
Human Molecular Genetics, 28 (23), pp. 3895-3911. 2019年10月

2. NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N
EMBO Reports, 19 (12), art. no. e46363 2018年10月

3. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.
Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K
Proceedings of the National Academy of Sciences of the United States of America 115(25) E5815-E5823 2018年6月

4. Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche.
Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E
Journal of neurochemistry 142(4) 534-544 2017年8月

5. Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.
Sadatsuki R, Kaneko H, Kinoshita M, Futami I, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 35(4) 837-846 2017年4月

6. Identification of peptides derived from the C-terminal domain of fibulin-7 active for endothelial cell adhesion and tube formation disruption.
de Vega S, Hozumi K, Suzuki N, Nonaka R, Seo E, Takeda A, Ikeuchi T, Nomizu M, Yamada Y, Arikawa-Hirasawa E
Biopolymers 106(2) 184-195 2016年3月

7. Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle.
Ning L, Xu Z, Furuya N, Nonaka R, Yamada Y, Arikawa-Hirasawa E
Matrix biology : journal of the International Society for Matrix Biology 48 26-35 2015年10月

8. A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space.
Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K
Neuromuscular disorders : NMD 25(8) 667-671 2015年8月

9. Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase.
Nonaka R, Iesaki T, de Vega S, Daida H, Okada T, Sasaki T, Arikawa-Hirasawa E
Physiological reports 3(1) 2015年1月

10. Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathway.
Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-Hirasawa E
The American journal of pathology 184(6) 1683-1694 2014年6月

11. Perlecan is required for FGF-2 signaling in the neural stem cell niche.
Kerever A, Mercier F, Nonaka R, de Vega S, Oda Y, Zalc B, Okada Y, Hattori N, Yamada Y, Arikawa-Hirasawa E
Stem cell research 12(2) 492-505 2014年3月

12. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture.
de Vega S, Suzuki N, Nonaka R, Sasaki T, Forcinito P, Arikawa-Hirasawa E, Yamada Y
Archives of biochemistry and biophysics 545 148-153 2014年3月

13. Domain 36 of tropoelastin in elastic fiber formation.
Nonaka R, Sato F, Wachi H
Biological & pharmaceutical bulletin 37(4) 698-702 2014年

14. Involvement of reactive oxygen species in abnormal tropoelastin deposition induced by UVA-photosensitizers
Satoshi Onoue, Risa Nonaka, Fumiaki Sato, Chiharu Koide, Akinobu Hayashi, Hiroshi Wachi
Journal of Health Science 55 946-951 2009年12月

15. DANCE/fibulin-5 promotes elastic fiber formation in a tropoelastin isoform-dependent manner.
Nonaka R, Onoue S, Wachi H, Sato F, Urban Z, Starcher BC, Seyama Y
Clinical biochemistry 42(7-8) 713-721 2009年5月

16. Characterization of the molecular interaction between tropoelastin and DANCE/fibulin-5.
Wachi H, Nonaka R, Sato F, Shibata-Sato K, Ishida M, Iketani S, Maeda I, Okamoto K, Urban Z, Onoue S, Seyama Y
Journal of biochemistry 143(5) 633-639 2008年5月

17. Distinct steps of cross-linking, self-association, and maturation of tropoelastin are necessary for elastic fiber formation.
Sato F, Wachi H, Ishida M, Nonaka R, Onoue S, Urban Z, Starcher BC, Seyama Y
Journal of molecular biology 369(3) 841-851 2007年6月

18. Domains 16 and 17 of tropoelastin in elastic fibre formation.
Wachi H, Sato F, Nakazawa J, Nonaka R, Szabo Z, Urban Z, Yasunaga T, Maeda I, Okamoto K, Starcher BC, Li DY, Mecham RP, Seyama Y
The Biochemical journal 402(1) 63-70 2007年2月


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