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研究業績詳細

笹澤 有紀子(ササザワ ユキコ)

研究テーマ オートファジーの化学生物学的解析
研究業績(論文) 1. Sasazawa Y, Hattori N, Saiki S. JNK‐interacting protein 4 is a central molecule for lysosomal retrograde trafficking, BioEssays e2300052 (2023)
2. Miyamoto K, Saiki S, Matsumoto H, Suzuki A, Yamashita Y, Iseki T, Ueno SI, Shiina K, Kataura T, Kamagata K, Imamichi Y, Sasazawa Y, Fujimaki M, Akamatsu W, Hattori N. Systemic Metabolic Alteration Dependent on the Thyroid-Liver Axis in Early PD. Ann Neurol. 93:303-316 (2023)
3. Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S. Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2. EMBO J. 41: e111476, (2022)
4. Saegusa J, Osada Y, Miura K, Sasazawa Y, Ogura A, Takao K, Simizu S. Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor. Bioorg Med Chem Lett. 60 128589 (2022)
5. Nakamura A, Kurihara S, Takahashi D, Ohashi W, Nakamura Y, Kimura S, Onuki M, Kume A, Sasazawa Y, Furusawa Y, Obata Y, Fukuda S, Saiki S, Matsumoto M, Hase K. Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon. Nat Commun. 12, 2105 (2021)
6. Kataura T., Tashiro E., Nishikawa S., Shibahara K., Muraoka Y., Miura M., Sakai S., Katoh N., Totsuka M., Onodera M., Shin-Ya K., Miyamoto K., Sasazawa Y., Hattori N., Saiki S., Imoto M. A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers. Autophagy 2020:1-17.
7. Kataura T., Saiki S., Ishikawa K.I., Akamatsu W., Sasazawa Y., Hattori N., Imoto M. BRUP-1, an intracellular bilirubin modulator, exerts neuroprotective activity in a cellular Parkinson's disease model. J Neurochem 2020;155(1):81-97.
8. Hirano K, Fujimaki M, Sasazawa Y, Yamaguchi A, Ishikawa KI, Miyamoto K, Souma S, Furuya N, Imamichi Y, Yamada D, Saya H, Akamatsu W, Saiki S, Hattori N. Neuroprotective effects of memantine via enhancement of autophagy. Biochem Biophys Res Commun. 518:161-170. (2019)
9. Saiki S*, Sasazawa Y* (*joint first authors), Fujimaki M, Kamagata K, Kaga N, Taka H, Li Y, Souma S, Hatano T, Imamichi Y, Furuya N, Mori A, Oji Y, Ueno SI, Nojiri 10, Miura Y, Ueno T, Funayama M, Aoki S, Hattori N. A metabolic profile of polyamines in Parkinson's disease: a promising biomarker. Ann. Neurol, 86, 251–263 (2019)
11. Otake K, Yamada K, Miura K, Sasazawa Y, Miyazaki S, Niwa Y, Ogura A, Takao KI, Simizu S. Identification of topoisomerases as molecular targets of cytosporolide C and its analog. Bioorg. Med. Chem. 27, 3334-8 (2019)
12. Otani K, Niwa Y, Suzuki T, Sato N, Sasazawa Y, Dohmae N, Simizu S. Regulation of granulocyte colony-stimulating factor receptor-mediated granulocytic differentiation by C-mannosylation. Biochem. Biophys. Res. Commun. 498, 466-472 (2018)
13. Matsuki Y, Miyazaki S, Yoshida K, Ogura A, Sasazawa Y, Takao K, Simizu, S. Synthesis and evaluation of biological activities of vibsanin A analogs. Bioorg. Med. Chem. Lett. 27(19) 4536-4539 (2017)
14. Fujimaki M, Saiki S, Sasazawa Y, Ishikawa KI, Imamichi Y, Sumiyoshi K, Hattori N. Immunocytochemical Monitoring of PINK1/ Parkin-Mediated Mitophagy in Cultured Cells. Methods Mol Biol. Berlin: Springer-Verlag (2017)
15. Okamoto S, Murano T, Suzuki T, Uematsu S, Niwa Y, Sasazawa Y, Dohmae N, Bujo H, Simizu S. Regulation of secretion and enzymatic activity of lipoprotein lipase by C-mannosylation. Biochem. Biophys. Res. Commun. 489, 558-563 (2017)
16. Fujiwara M, Kato S, Niwa Y, Suzuki T, Tsuchiya M, Sasazawa Y, Dohmae N, Simizu S. C-mannosylation of R-spondin3 regulates its secretion and activity of Wnt/β-catenin signaling in cells. FEBS Lett.590, 2639-49
17. Miyazaki S, Sasazawa Y, Mogi T, Suzuki T, Yoshida K, Dohmae N, Takao K, Simizu S. Identification of seco-clavilactone B as a small-molecule actin polymerization inhibitor. FEBS Lett. 590, 1163-73 (2016)
18. Katsuyama S, Sugino K, Sasazawa Y, Nakano Y, Aono H, Morishita K, Kawatani M, Umezawa K, Osada H, Simizu S. Identification of a novel compound that inhibits osteoclastogenesis by suppressing nucleoside transporters. FEBS Lett. 590, 1152-62 (2016)
19. Sasazawa Y, Sato N, Suzuki T, Dohmae N, Simizu S. C-mannosylation of thrombopoietin receptor (c-Mpl) regulates thrombopoietin-dependent JAK-STAT signaling. Biochem Biophys Res Commun. 468, 262-8 (2015)
20. Komai K, Niwa Y, Sasazawa Y, Simizu S. Pirin regulates the epithelial to mesenchymal transition independently of Bcl3-Slug signaling. FEBS Lett. 589, 738-43 (2015)
21. Sasazawa Y, Sato N, Umezawa K, Simizu S. Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of rapamycin (mTOR)-independent autophagy. J. Biol. Chem. 290, 6168-78 (2015)
22. Kiga M, Nakayama A, Shikata Y, Sasazawa Y, Murakami R, Nakanishi T, Tashiro E, Imoto M. SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors. Sci. Rep. 5, 8155, (2015)
23. Iwasaki A, Ohno O, Katsuyama S, Morita M, Sasazawa Y, Dan S, Simizu S, Yamori T, Suenaga K. Identification of a molecular target of kurahyne, an apoptosis-inducing lipopeptide from marine cyanobacterial assemblages. Bioorg Med Chem Lett. 25, 5295-8 (2015)
24. Uematsu S, Goto Y, Suzuki T, Sasazawa Y, Dohmae N, Simizu S. N-glycosylation of extracellular matrix protein 1 (ECM1) regulates its secretion, which is unrelated to lipoid proteinosis. FEBS Open Bio 4, 879-85 (2014)
25. Ukaji T, Sasazawa Y, Umezawa K, Simizu S. Involvement of conserved tryptophan residues for secretion of TIMP-2, Oncol Lett. 7, 631-4 (2014)
26. Kuroda M, Funasaki S, Saitoh T, Sasazawa Y, Nishiyama S, Umezawa K, Simizu S. Determination of topological structure of ARL6ip1 in cells: identification of the essential binding region of ARL6ip1 for conophylline, FEBS Lett. 587, 3656-60 (2013)
27. Sasazawa Y, Kanagaki S, Tashiro E, Nogawa T, Muroi M, Kondoh Y, Osada H, Imoto M. Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein, ACS Chem Biol. 7, 892-900 (2012)
28. Kiga M, Tanzawa F, Iwasaki, Inaba F, Fujiwara K, Iwadare H, Echigo T, Nakamura Y, Shibata T, Suzuki K, Yasumatsu I, Nakayama A, Sasazawa Y, Tashiro E, Imoto M, Kurakata S. Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17, Anti-cancer drugs 23, 119-30 (2012)
29. Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Sato S, Ishikawa K, Imoto M, Hattori N. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition, Autophagy 7, 176-87 (2011)
30. Sasazawa Y, Futamura Y, Tashiro E, Imoto M. Vacuolar H+-ATPase inhibitors overcome Bcl-xL-mediated chemoresistance through restoration of a caspase-independent apoptotic pathway, Cancer Sci. 100, 1460-7 (2009)

[著書・総説]
1. 笹澤有紀子, 斉木臣二「リソソームの細胞内分布制御の破綻と神経変性疾患」実験医学 特集 リソソームの新機能 分解の場からコントロールセンターへ 41(11) 1748-1753, 2023
2. Sasazawa Y, Hattori N, Saiki S. Development of autophagy enhancers for Parkinson's disease therapy. ”Autophagy Dysfunction in Alzheimer's Disease and Dementia” Elsevier books , 305-320, 2022
3. 笹澤有紀子、斉木臣二「メタボロミクス」順天堂大学ではこうしている、日本医事新報社、最新パーキンソン病診療 服部信孝編 54-55 (2021)
4. 笹澤有紀子, 斉木臣二, 服部信孝 「血清中ポリアミン」CLINICAL NEUROSCIENCE 中外医学社 38(7) 859-861, 2020年
5. 笹澤有紀子, 斉木臣二, 井本正哉 「パーキンソン病治療薬の開発展望」 バイオインダストリー 、シーエムシー出版 35, 1-9, 2018年
6. Fujimaki M., Saiki S., Sasazawa Y., Ishikawa K.I., Imamichi Y., Sumiyoshi K., Hattori N. Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells. Methods Mol Biol 2018; 1759:19-27.
7. 笹澤有紀子、井本正哉「アポトーシス耐性のがんに挑む—V-ATPase阻害剤の新たな可能性—」生体の科学、医学書院61: 614-18 (2010)
8. 笹澤有紀子、井本正哉「抗がん剤の効かないがんに挑む —アポトーシス抑制タンパク質Bcl-xL機能阻害剤の発見—」化学、化学同人64:74-5 (2009)

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