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須山(古宮) 栄利子（スヤマ(コミヤ) エリコ）

研究テーマ	現在：かゆみの調節メカニズム　2014年まで：慢性炎症 (がん微小環境) およびDrug deliverly system (DDS)
研究業績（論文）	1.Toyama S, Tominaga M, Komiya E, Kusano S, Kaneko T, Takamori K:Oral administration of 4’-demethyl nobiletin inhibits dry skin-induced mechanical alloknesis. Itch 8(3), 2023 IF: /CI:0 2.Kishi R, Toyama S, Tominaga M, Kamata Y, Komiya E, Kaneko T, Suga Y, Takamori K:Effects of Dupilumab on Itch-Related Events in Atopic Dermatitis: Implications for Assessing Treatment Efficacy in Clinical Practice. Cells.12(2):239, 2023 IF:6.0 /CI:0 3. Komiya E, Tominaga M, Hatano R, Kamikubo Y, Toyama S, Sakairi H, Honda K, Itoh T, Kamata Y, Tsurumachi M, Kishi R, Ohnuma K, Sakurai T, Morimoto C, Takamori K: Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. J Allergy Clin Immunol. 149(3):1085-1096, 2022, Press Release IF: 14.2 /CI: 3 4. Komiya E, Tominaga M, Kamata Y, Y Suga, Takamori K: Molecular and Cellular Mechanisms of Itch in Psoriasis, Int J Mol Sci.; 21(21): 8406, 2020, IF:5.6 / CI:36 5.Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K: Calcium-Inducible MAPK/AP-1 Signaling Drives Semaphorin 3A Expression in Normal Human Epidermal Keratinocytes. J Invest Dermatol. 140(7): 1346-1354, 2020, IF: 6.5 /CI: 5 6.Hatano R, Itoh T, Otsuka H, Okamoto S, Komiya E, Iwata S, Aune TM, Dang NH, Kuwahara-Arai K, Ohnuma K, Morimoto C: Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis. mabs ; 11(8):1428-1442, 2019　IF:5.3 / CI:9 7. Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K: Biological Effects of IL-26 on T Cell-Mediated Skin Inflammation, Including Psoriasis. J Invest Dermatol. 139:878-889, 2019, IF:6.5 /CI: 28 8. Hatano R, Yamada, Madokoro, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S, Dang NH, Ohnuma K, Morimoto C：Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens.PLoS One.　14(6):e0218330, 2019, IF 3.7 /CI 3 9.Ohnuma K, Hatano R, Komiya E, Otsuka H, Itoh T, Iwao N, Kaneko Y, Yamada T, Dang NH, Morimoto C:A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target. Frontiers in Bioscience-Landmark 23(9)1754-1779, 2018, IF4.009 /CI:20 10.Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U,Takamori K, Morimoto C, Ohnuma K: A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus. J Dermatol Sci. 86:212-221, 2017, IF:4.6 /CI: 7 11. Nomura S, Iwata S, Hatano R, Komiya E, Dang N H, Iwao N, Ohnuma K, Morimoto C: Inhibition of VEGF-dependent angiogenesis by anti-CD82 monoclonal antibody 4F9 through regulation of lipid raft microdomains. Biochem Biophys Res Commun. 474:111-117, 2016, IF:3.1 /CI:5 12. Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, Dang N.H, Okumura K, Morimoto C: CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway. J Immunol. 194:960-972, 2015, 4.4 /CI:20 ⑬. Komiya E, Sato H, Watanabe N, Ise M, Higashi S, Miyagi Y, Miyazaki K: Angiomodulin, a marker of cancer vasculature, is upregulated by vascular endothelial growth factor and increases vascular permeability as a ligand of integrin αvβ3. Cancer med. 3:537-549, 2014, 4.0 /CI:18 14. Komiya E, Ohnuma K, Yamazaki H, Hatano R, Iwata S, Okamoto T, Dang N H, Yamada T, Morimoto C: CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells. Biochem Biophys Res Commun. 447:609-615, 2014, IF:3.1 /CI:19 15. Yamamoto J, Ohnuma K, Hatano R, Okamoto T, Komiya E, Yamazaki H, Iwata S, Dang N H, Aoe K, Kishimoto T, Yamada T, Morimoto C: Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma. Br J Cancer. 110:2232-2245, 2014, IF:8.8 /CI:15 16. Kamoshida G, Ogawa T, Oyanagi J, Sato H, Komiya E, Higashi S, Miyazaki K, Tsuji T: Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5). Clin Exp metastasis. 31:285-291, 2014, IF: IF: 4.0 /CI: 6 17. Sato H, Oyanagi J, Komiya E, Ogawa T, Higashi S, Miyazaki K: Amino-terminal fragments of laminin γ2 chain react vascular endothelial cells and increase vascular permeability. Cancer sci. 105:168-175, 2014, IF: 4.51/CI:8 18. Hatano R, Yamada T, Matsuoka S, Iwata S, Yamazaki H, Komiya E, Okamoto T, Dang N H, Ohnuma K, Morimoto C: Establishment of monoclonal anti-human CD26 antibodies suitable for immunostaining of formalin-fixed tissue. Diagn Pathol. 9:30, 2014, IF:2.6 /CI: 8 19. Okamoto T, Iwata S, Yamazaki H, Hatano R, Komiya E, Dang N H, Ohnuma K, Morimoto C: CD9 negatively regulates CD26 expression and inhibits CD26-mediated enhancement of invasive potential of malignant mesothelioma cells. PLoS ONE. 9(1):e86671, 2014, IF:3.7 /CI:26 ⑳．Komiya E, Furuya M, Watanabe N, Miyagi Y, Higashi S, Miyazaki K: Elevated expression of angiomodulin (AGM/IGFBP-rP1) in tumor stroma and its roles in fibroblast activation. Cancer sci. 103:691-699, 2012, IF: 5.7 /CI: 17 21. Mori T, Kariya K, Komiya E, Higashi S, Miyagi Y, Sekiguchi K, Miyazaki K: Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers. Cancer sci. 102:1095-1100, 2011, IF:5.7 /CI:7 22. Takahashi A, Komiya E, Kakutani H, Yosida T, Fujii M, Horiguchi Y, Mizuguchi H, Tsutsumi Y, Tsunoda S, Koizumi N, Isoda K, Yagi K, Watanabe Y, Kondoh M: Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem Pharmacol. 75:1639-1648, 2008, IF: 5.8 /CI:61 23. Harada M, Kondoh M, Ebihara C, Takahashi A, Komiya E, Fujii M, Mizuguchi H, Tsunoda S, Yagi K, Watanabe Y: Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol. 73:206-214, 2007, IF: 5.8 /CI:41 24. Komiya E, Kondoh M, Mizuguchi H, Utoguchi N, Nakanishi T, Watanabe Y: Characteristics of transcription-regulatory elements for gene expression from plasmid vectors in human trophoblast cell lines. Placenta. 27:934-938, 2006, IF: 3.8 /CI:2

研究テーマ

現在：かゆみの調節メカニズム　2014年まで：慢性炎症 (がん微小環境) およびDrug deliverly system (DDS)

研究業績（論文）

1.Toyama S, Tominaga M, Komiya E, Kusano S, Kaneko T, Takamori K:Oral administration of 4’-demethyl nobiletin inhibits dry skin-induced mechanical alloknesis. Itch 8(3), 2023 IF: /CI:0

2.Kishi R, Toyama S, Tominaga M, Kamata Y, Komiya E, Kaneko T, Suga Y, Takamori K:Effects of Dupilumab on Itch-Related Events in Atopic Dermatitis: Implications for Assessing Treatment Efficacy in Clinical Practice. Cells.12(2):239, 2023 IF:6.0 /CI:0

3. Komiya E, Tominaga M, Hatano R, Kamikubo Y, Toyama S, Sakairi H, Honda K, Itoh T, Kamata Y, Tsurumachi M, Kishi R, Ohnuma K, Sakurai T, Morimoto C, Takamori K: Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. J Allergy Clin Immunol. 149(3):1085-1096, 2022, Press Release IF: 14.2 /CI: 3

4. Komiya E, Tominaga M, Kamata Y, Y Suga, Takamori K: Molecular and Cellular Mechanisms of Itch in Psoriasis, Int J Mol Sci.; 21(21): 8406, 2020, IF:5.6 / CI:36

5.Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K: Calcium-Inducible MAPK/AP-1 Signaling Drives Semaphorin 3A Expression in Normal Human Epidermal Keratinocytes. J Invest Dermatol. 140(7): 1346-1354, 2020, IF: 6.5 /CI: 5

6.Hatano R, Itoh T, Otsuka H, Okamoto S, Komiya E, Iwata S, Aune TM, Dang NH, Kuwahara-Arai K, Ohnuma K, Morimoto C: Characterization of novel anti-IL-26 neutralizing monoclonal antibodies for the treatment of inflammatory diseases including psoriasis. mabs ; 11(8):1428-1442, 2019　IF:5.3 / CI:9

7. Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K: Biological Effects of IL-26 on T Cell-Mediated Skin Inflammation, Including Psoriasis. J Invest Dermatol. 139:878-889, 2019, IF:6.5 /CI: 28

8. Hatano R, Yamada, Madokoro, Otsuka H, Komiya E, Itoh T, Narita Y, Iwata S, Yamazaki H, Matsuoka S, Dang NH, Ohnuma K, Morimoto C：Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens.PLoS One.　14(6):e0218330, 2019, IF 3.7 /CI 3

9.Ohnuma K, Hatano R, Komiya E, Otsuka H, Itoh T, Iwao N, Kaneko Y, Yamada T, Dang NH, Morimoto C:A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target. Frontiers in Bioscience-Landmark 23(9)1754-1779, 2018, IF4.009 /CI:20

10.Komiya E, Hatano R, Otsuka H, Itoh T, Yamazaki H, Yamada T, Dang NH, Tominaga M, Suga Y, Kimura U,Takamori K, Morimoto C, Ohnuma K: A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus. J Dermatol Sci. 86:212-221, 2017, IF:4.6 /CI: 7

11. Nomura S, Iwata S, Hatano R, Komiya E, Dang N H, Iwao N, Ohnuma K, Morimoto C: Inhibition of VEGF-dependent angiogenesis by anti-CD82 monoclonal antibody 4F9 through regulation of lipid raft microdomains. Biochem Biophys Res Commun. 474:111-117, 2016, IF:3.1 /CI:5

12. Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, Dang N.H, Okumura K, Morimoto C: CD26-Mediated Induction of EGR2 and IL-10 as Potential Regulatory Mechanism for CD26 Costimulatory Pathway. J Immunol. 194:960-972, 2015, 4.4 /CI:20

⑬. Komiya E, Sato H, Watanabe N, Ise M, Higashi S, Miyagi Y, Miyazaki K: Angiomodulin, a marker of cancer vasculature, is upregulated by vascular endothelial growth factor and increases vascular permeability as a ligand of integrin αvβ3. Cancer med. 3:537-549, 2014, 4.0 /CI:18

14. Komiya E, Ohnuma K, Yamazaki H, Hatano R, Iwata S, Okamoto T, Dang N H, Yamada T, Morimoto C: CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells. Biochem Biophys Res Commun. 447:609-615, 2014, IF:3.1 /CI:19

15. Yamamoto J, Ohnuma K, Hatano R, Okamoto T, Komiya E, Yamazaki H, Iwata S, Dang N H, Aoe K, Kishimoto T, Yamada T, Morimoto C: Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma. Br J Cancer. 110:2232-2245, 2014, IF:8.8 /CI:15

16. Kamoshida G, Ogawa T, Oyanagi J, Sato H, Komiya E, Higashi S, Miyazaki K, Tsuji T: Modulation of matrix metalloproteinase-9 secretion from tumor-associated macrophage-like cells by proteolytically processed laminin-332 (laminin-5). Clin Exp metastasis. 31:285-291, 2014, IF: IF: 4.0 /CI: 6

17. Sato H, Oyanagi J, Komiya E, Ogawa T, Higashi S, Miyazaki K: Amino-terminal fragments of laminin γ2 chain react vascular endothelial cells and increase vascular permeability. Cancer sci. 105:168-175, 2014, IF: 4.51/CI:8

18. Hatano R, Yamada T, Matsuoka S, Iwata S, Yamazaki H, Komiya E, Okamoto T, Dang N H, Ohnuma K, Morimoto C: Establishment of monoclonal anti-human CD26 antibodies suitable for immunostaining of formalin-fixed tissue. Diagn Pathol. 9:30, 2014, IF:2.6 /CI: 8

19. Okamoto T, Iwata S, Yamazaki H, Hatano R, Komiya E, Dang N H, Ohnuma K, Morimoto C: CD9 negatively regulates CD26 expression and inhibits CD26-mediated enhancement of invasive potential of malignant mesothelioma cells. PLoS ONE. 9(1):e86671, 2014, IF:3.7 /CI:26

⑳．Komiya E, Furuya M, Watanabe N, Miyagi Y, Higashi S, Miyazaki K: Elevated expression of angiomodulin (AGM/IGFBP-rP1) in tumor stroma and its roles in fibroblast activation. Cancer sci. 103:691-699, 2012, IF: 5.7 /CI: 17

21. Mori T, Kariya K, Komiya E, Higashi S, Miyagi Y, Sekiguchi K, Miyazaki K: Downregulation of a newly identified laminin, laminin-3B11, in vascular basement membranes of invasive human breast cancers. Cancer sci. 102:1095-1100, 2011, IF:5.7 /CI:7

22. Takahashi A, Komiya E, Kakutani H, Yosida T, Fujii M, Horiguchi Y, Mizuguchi H, Tsutsumi Y, Tsunoda S, Koizumi N, Isoda K, Yagi K, Watanabe Y, Kondoh M: Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem Pharmacol. 75:1639-1648, 2008, IF: 5.8 /CI:61

23. Harada M, Kondoh M, Ebihara C, Takahashi A, Komiya E, Fujii M, Mizuguchi H, Tsunoda S, Yagi K, Watanabe Y: Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol. 73:206-214, 2007, IF: 5.8 /CI:41

24. Komiya E, Kondoh M, Mizuguchi H, Utoguchi N, Nakanishi T, Watanabe Y: Characteristics of transcription-regulatory elements for gene expression from plasmid vectors in human trophoblast cell lines. Placenta. 27:934-938, 2006, IF: 3.8 /CI:2

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研究業績詳細

須山(古宮) 栄利子（スヤマ(コミヤ) エリコ）