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研究テーマ interplay beetween mithophagy, infections on neuroinflammation and neurodegenerative diseases
研究業績(論文) Cossu D, Tomizawa Y, Momotani E, Yokoyama K, Hattori N. Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis. J Vis Exp. 2023 May 12;(195).
Cossu D, Yokoyama K, Sakanishi T, Sechi LA, Hattori N. Bacillus Calmette-Guérin Tokyo-172 vaccine provides age-related neuroprotection in actively induced and spontaneous experimental autoimmune encephalomyelitis models. Clin Exp Immunol. 2023 Apr 7;212(1):70-80.
Cossu D, Yokoyama K, Sato S, Noda S, Sakanishi T, Sechi LA, Hattori N. Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice. Front Immunol. 2022 Nov 17;13:1036680
Cossu D, Ruberto S, Yokoyama K, Hattori N, Sechi LA. Efficacy of BCG vaccine in animal models of neurological disorders. Vaccine. 2022
Cossu D, Yokoyama K, Sato S, Noda S, Sechi LA, Hattori N. PARKIN modifies peripheral immune response and increases neuroinflammation in active experimental autoimmune encephalomyelitis (EAE). J Neuroimmunol. 2021
Cossu D, Yokoyama K, Sechi LA, Hattori N. Potential of PINK1 and PARKIN proteins as biomarkers for active multiple sclerosis: a Japanese cohort study. Front Immunol. 2021
Cossu D, Yokoyama K, Sakanishi T, Momotani E and Hattori N. Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 2019
Yokoyama K, Cossu D, Hoshino Y, Tomizawa Y, Momotani E, Hattori N. Anti-mycobacterial antibodies in paired cerebrospinal and serum samples from Japanese patients with multiple sclerosis or neuromyelitis optica spectrum disorder. J Clin Med, 7(12), 522, 2018.
Cossu D, Yokoyama K, Hattori N. Bacteria-host interactions in multiple sclerosis. Front. microbiol, 9:2966, 2018.
Cossu D, Yokoyama K, Tomizawa Y, Momotani E, Hattori N. Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system. Sci Rep, 7(1):3179, 2017.
Cossu D, Yokoyama K, Hattori N. Conflicting Role of Mycobacterium Species in Multiple Sclerosis. Front. Neurol, 8:216, 2017.
Cossu D, Yokoyama K, Sechi LA, Otsubo S, Tomizawa Y, Momotani E, Hattori N. Humoral response against host-mimetic homologous epitopes of Mycobacterium avium susp. paratuberculosis in Japanese multiple sclerosis patients. Sci Rep, 30; 6:29227, 2016.
Cossu D, Mameli G, Galleri G, Cocco E, Masala S, Frau J, Marrosu MG, Manetti R, Sechi LA. Human interferon regulatory factor 5 homologous epitopes of Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis induce a specific humoral and cellular immune response in multiple sclerosis patients. Mult Scler, Vol. 21(8), pp. 984-995, 2014.
Cossu D, Mameli G, Masala S, Cocco E, Frau J, Marrosu MG, Sechi LA. Evaluation of the humoral response against mycobacterial peptides, homologous to MOG35-55, in multiple sclerosis patients. J Neurol Sci, Vol. 347(1-2), pp. 78-81, 2014.
Cossu D, Masala S, Frau J, Mameli G, Marrosu MG, Cocco E, Sechi LA. Antigenic epitopes of MAP2694 homologous to T-cell receptor gamma-chain are highly recognized in MS Sardinian patients. Mol Immunol, Vol. 57(2), pp. 138-140, 2014.
Cossu D, Masala S, Frau J, Cocco E, Marrosu MG, Sechi LA. Anti-Mycobacterium avium ss. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis. J Neurol Sci, Vol. 335(1-2), pp. 131-133, 2013.
Cossu D, Masala S, Cocco E, Paccagnini D, Tranquilli S, Frau J, Marrosu MG, Sechi LA. Association of Mycobacterium avium ss. paratuberculosis and SLC11A1 polymorphisms in Sardinian MS patients. J Infect Dev Ctries, Vol. 7(3), pp. 203-207, 2013.
Cossu D, Masala S, Sechi LA. A Sardinian map for multiple sclerosis. Future Microbiol, Vol. 8(2), pp. 223-232, 2013.
Cossu D, Masala S, Cocco E, Paccagnini D, Frau J, Marrosu MG, Sechi LA. Are Mycobacterium avium subsp. paratuberculosis and Epstein-Barr virus triggers of multiple sclerosis in Sardinia? Mult Scler, Vol. 18(8), pp. 1181-1184, 2012.
Cossu D, Cocco E, Paccagnini D, Masala S, Ahmed N, Frau J, Marrosu MG, Sechi LA. Association of Mycobacterium avium subsp. paratuberculosis with multiple sclerosis in Sardinian patients. Plos One, Vol. 6(4):e18482, 2011.

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