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研究業績詳細

中村 哲也(ナカムラ テツヤ)

研究テーマ 腸上皮細胞の増殖・分化機構解明とこれに基づく再生医療技術開発
研究業績(論文) Suda K, Matsumoto Y, Ochi T, Koga H, Lane GJ, Hattori N, Nakamura T, Yamataka A. Successful engraftment of bladder organoids in de-epithelialized mouse colon. Pediatr Surg Int. 2022 Nov 30;39(1):14. doi: 10.1007/s00383-022-05294-w.PMID: 36449180

Watanabe S, Kobayashi S, Ogasawara N, Okamoto R, Nakamura T, Watanabe M, Jensen KB, Yui S. Transplantation of intestinal organoids into a mouse model of colitis. Nature Protoc.17(3):649:2022. 10.1038/s41596-021-00658-3

Matsumoto Y, Koga H, Takahashi M, Suda K, Ochi T, Seo S, Miyano G, Miyake Y, Nakajima H, Yoshida S, Mikami T, Okazaki T, Hattori N, Yamataka A, Nakamura T. Defined serum-free culture of human infant small intestinal organoids with predetermined doses of Wnt3a and Rspondin1 from surgical specimens. Pediatr Surg Int. 37(11):1543-1554:2021

Watanabe S, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Kirimura S, Negi M, Okamoto R, Matsumoto Y, Nakamura T, Watanabe M, Tsuchiya K. Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis. J Crohns Colitis. 15(9):1558-1572:2021

Naraoka Y, Mabuchi Y, Yoneyama Y, Suto EG, Hisamatsu D, Ikeda M, Ito R, Nakamura T, Takebe T, Akazawa C. Isolation and Characterization of Tissue Resident CD29-Positive Progenitor Cells in Livestock to Generate a Three-Dimensional Meat Bud. Cells. 10(9):2499:2021. 10.3390/cells10092499

Morikawa R, Nemoto Y, Yonemoto Y, Tanaka S, Takei Y, Oshima S, Nagaishi T, Tsuchiya K, Nozaki K, Mizutani T, Nakamura T, Watanabe M, Okamoto R. Intraepithelial lymphocytes suppress the intestinal tumor growth by cell-to-cell contact via CD103/E-cadherin signal. Cell Mol Gastroenterol Hepatol. 11(5):1483-1503:2021

Aonuma E, Tamura A, Matsuda H, Asakawa T, Sakamaki Y, Otsubo K, Nibe Y, Onizawa M, Nemoto Y, Nagaishi T, Tsuchiya K, Nakamura T, Uo M, Watanabe M, Okamoto R, Oshima S. Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Biochem Biophys Res Commun. 542:17-23:2021

Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. FEBS Lett. 594(10):1586-1595: 2020

Takei Y, Nemoto Y, Morikawa R, Tanaka S, Oshima S, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M. CD8αα+ T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo. Biochem Biophys Res Commun. 523(2):328-335: 2020

Tanaka S, Nemoto Y, Takei Y, Morikawa R, Oshima S, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Stutte S, Watanabe M. High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage. Biochem Biophys Res Commun. 522(4):971-977: 2020

Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M. TP53 mutation by CRISPR system enhances the malignant potential of colon cancer. Mol Cancer Res. 17(7):1459-1467: 2019

Nishimura R, Shirasaki T, Tsuchiya K, Miyake Y, Watanabe Y, Hibiya S, Watanabe S, Nakamura T, Watanabe M. Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids. J Gastroenterol. 54(7): 608-620: 2019

Kawamoto A, Nagata S, Anzai S, Takahashi J, Kawai M, Hama M, Nogawa D, Yamamoto K, Kuno R, Suzuki K, Shimizu H, Hiraguri Y, Yui S, Ohshima S, Tsuchiya K, Nakamura T, Ohtsuka K, Kitagawa M, Okamoto R, Watanabe M. Ubiquitin D is up-regulated by synergy of Notch signalling and TNF-α in the inflamed intestinal epithelia of IBD patients. J Crohns Colitis. 13(4): 495-509: 2019

Nakamura T Recent Progress in Organoid Culture to Model Intestinal Epithelial Barrier Functions. Int Immunol. 31(1): 13-21: 2019 (§corresponding author)

Suzuki K, Murano T, Shimizu H, Ito G, Nakata T, Fujii S, Ishibashi F, Kawamoto A, Anzai S, Kuno R, Kuwabara K, Takahashi J, Hama M, Nagata S, Hiraguri Y, Takenaka K, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R. Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties. J Gastroenterol. 53(9): 1035-1047: 2018

Watabe T, Nagaishi T, Tsugawa N, Kojima Y, Nisha J, Hosoya A, Onizawa M, Nemoto Y, Oshima S, Nakamura T, Karasuyama H, Adachi T, Watanabe M. B cell activation in the cecal patches during the development of an experimental colitis model. Biochem Biophys Res Commun. 496(2): 367-373: 2018

Sugimoto S, Ohta Y, Fujii M, Matano M, Shimokawa M, Nanki K, Date S, Nishikori S, Nakazato Y, Nakamura T, Kanai T, Sato T. Reconstruction of the human colon epithelium in vivo. Cell Stem Cell. 22(2): 171-176: 2018

Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL, Guiu J, Alves MRP, Rundsten CF, Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB. YAP/TAZ-dependent reprogramming of colonic epithelisum links ECM remodeling to tissue regeneration. Cell Stem Cell. 22(1): 35-49: 2018

Ishibashi F, Shimizu H, Nakata T, Fujii S, Suzuki K, Kawamoto A, Anzai S, Kuno R, Nagata S, Ito G, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Contribution of ATOH1+ cells to the homeostasis, repair and tumorigenesis of the colonic epithelium. Stem Cell Reports. 10(1): 27-42: 2018

Nibe Y, Oshima S, Kobayashi M, Maeyashiki C, Matsuzawa Y, Otsubo K, Matsuda H, Aonuma E, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Nakada S, Watanabe M. Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by /SQSTM1/p62. Autophagy. 14(2): 347-358: 2018

Nakamura T and Sato T: Advancing intestinal organoid technology toward regenerative medicine. Cell Mol Gastroenterol Hepatol. 5(1): 51-60: 2017 (§ co-corresponding authors)

Akiyama S, Mochizuki W, Nibe Y, Matsumoto Y, Sakamoto K, Oshima S, Watanabe M, Nakamura T: CCN3 expression marks a sulfomucin-nonproducing unique subset of colonic goblet cells in mice. Acta Histochem Cytochem. 50(6): 159-168: 2017

Suzuki N, Sekimoto K, Hayashi C, Mabuchi Y, Nakamura T, Akazawa C. Differentiation of oligodendrocyte precursor cells from Sox10-Venus mice to oligodendrocytes and astrocytes. Sci Rep 7(1): 14133: 2017. 10.1038/s41598-017-14207-0

Matsumoto Y, Mochizuki W, Akiyama S, Matsumoto T, Nozaki K, Watanabe M, Nakamura T: Distinct intestinal adaptation for vitamin B12 and bile acid absorption revealed in a new mouse model of massive ileocecal resection. Biol Open. 6(9): 1364-1374: 2017

Maeyashiki C, Oshima S, Otsubo K, Kobayashi M, Nibe Y, Matsuzawa Y, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M: HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem Biophys Res Commun. 484(3): 636-641:2017

Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Kuno R, Anzai S, Murano T, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Hozumi K, Watanabe M, Okamoto R: Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem Biophys Res Commun. 482(4): 1296-1303: 2017

Nakamura T and Watanabe M: Intestinal stem cell transplantation. J Gastroenterol. 52(2): 151-157: 2017

Hibiya S, Tsuchiya K, Hayashi R, Fukushima K, Horita N, Watanabe S, Shirasaki T, Nishimura R, Kimura N, Nishimura T, Gotoh N, Oshima S, Okamoto R, Nakamura T, Watanabe M: Long-term inflammation transforms intestinal epithelial cells of colonic organoids. J Crohns Colitis. 11(5): 621-630: 2017

Kobayashi M, Oshima S, Maeyashiki C, Nibe Y, Otsubo K, Matsuzawa Y, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M: The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 6: 36780: 2016. 10.1038/srep36780

Fujii S, Suzuki K, Kawamoto A, Ishibashi F, Nakata T, Murano T, Ito G, Shimizu H, Mizutani T, Oshima S, Tsuchiya K, Nakamura T, Araki A, Ohtsuka K, Okamoto R, Watanabe M. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 6: 36795: 2016. 10.1038/srep36795

Matsumoto T*, Mochizuki W*, Nibe Y, Akiyama S, Matsumoto Y, Nozaki K, Fukuda M, Hayashi A, Mizutani T, Oshima S, Watanabe M, Nakamura T: Retinol promotes in vitro growth of proximal colon organoids through a retinoic acid-independent mechanism. PLoS One. 11(8): e0162049. 2016. 10.1371/journal.pone.0162049

Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M. Reduced human α-defensin 6 in noninflamed jejunal tissue of patients with Crohn's disease. Inflamm Bowel Dis. 22(5): 1119-1128: 2016

Nozaki K, Mochizuki W, Matsumoto Y, Matsumoto T, Fukuda M, Mizutani T, Watanabe M, Nakamura T: Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J Gastroenterol 51(3): 206-213: 2016

Fukushima K, Tsuchiya K, Kano Y, Horita N, Hibiya S, Hayashi R, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Oshima S, Nagaishi T, Okamoto R, Nakamura T, Watanabe M: Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci. 106(8): 1000-1007: 2015

Matsuzawa Y, Oshima S, Takahara M, Maeyashiki C, Nemoto Y, Kobayashi M, Nibe Y, Nozaki K, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Ma A, Watanabe M: TNFAIP3 promotes survival of CD4 T cells by restricting mTOR and promoting autophagy. Autophagy. 11(7): 1052-1062: 2015

Matsuzawa Y, Oshima S, Nibe Y, Kobayashi M, Maeyashiki C, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Watanabe M: RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem Biophys Res Commun. 456(1): 298-304: 2015.

Nakamura T. Epithelial regeneration by transplantation of cultured intestinal stem cells. Inflammation and Regeneration. 35(1): 19-22: 2015.

Horita N, Tsuchiya K, Hayashi R, Fukushima K, Hibiya S, Fukuda M, Kano Y, Mizutani T, Nemoto Y, Yui S, Okamoto R, Nakamura T, Watanabe M: Fluorescent labeling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun. 454(4): 493-499: 2014

Fukuda M*, Mizutani T*, Mochizuki W, Matsumoto T, Nozaki K, Sakamaki Y, Ichinose S, Okada Y, Tanaka T, Watanabe M, Nakamura T: Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 28(16): 1752-1757: 2014

Suzuki M, Nagaishi T, Yamazaki M, Onizawa T, Watabe T, Sakamaki Y, Ichinose S, Totsuka M, Oshima S, Okamoto R, Shimonaka M, Yagita H, Nakamura T, Watanabe M: Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS One. 9(2): e88369. 2014. 10.1371/journal.pone.0088369

Murano T, Okamoto R, Ito G, Nakata T, Hibiya S, Shimizu H, Fujii S, Kano Y, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Tsuchiya K, Nakamura T, Watanabe M: Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem Biophys Res Commun. 443(3): 840-846: 2014

Fordham RP, Yui S, Hannan NRF, Søndergaard C, Madgwick A, Schweiger PJ, Nielsen OH, Vallier L, Pedersen RA, Nakamura T, Watanabe M, Jensen KB: Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury. Cell Stem Cell. 13(6): 734-744: 2013

Ito G, Okamoto R, Murano T, Shimizu H, Fujii S, Nakata T, Mizutani T, Yui S, Akiyama-Morio J, Nemoto Y, Okada E, Araki A, Ohtsuka K, Tsuchiya K, Nakamura T, Watanabe M: Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells. PLoS One. 8(11): e79693. 2013. 10.1371/journal.pone.0079693

Takahara M, Nemoto Y, Oshima S, Matsuzawa Y, Kanai T, Okamoto R, Tsuchiya K, Nakamura T, Yamamoto K, Watanabe M: IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol Letters. 156(1-2): 82-93. 2013

Kano Y, Tsuchiya K, Zheng X, Horita N, Fukushima K, Hibiya S, Yamauchi Y, Nishimura T, Hinohara K, Gotoh N, Suzuki S, Okamoto R, Nakamura T, Watanabe M: The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem Biophys Res Commun. 432(1): 175-181: 2013

Nemoto Y, Kanai T, Takahara M, Oshima S, Nakamura T, Okamoto R, Tsuchiya K, Watanabe M: Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut. 62(8): 1142-1152: 2012

Yui S*, Nakamura T*, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, Watanabe M: Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nat Med. 18(4): 618-623: 2012

Yamaji O, Nagaishi T, Totsuka T, Onizawa M, Suzuki M, Tsuge N, Hasegawa A, Okamoto R, Tsuchiya K, Nakamura T, Arase H, Kanai T, Watanabe M: The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis. J Immunol. 188(6): 2524-2536: 2012

Mizutani T*, Nakamura T*, , Morikawa R, Fukuda M, Mochizuki W, Yamauchi Y, Nozaki K, Yui S, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Watanabe M: Real-time analysis of P-glycoprotein -mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem Biophys Res Commun. 419(2): 238-243: 2012

Nemoto Y, Kanai T, Shinohara T, Ito T, Nakamura T, Okamoto R, Tsuchiya K, Lipp M, Eishi Y, Watanabe M: Luminal CD4+ T Cells Penetrate Gut Epithelial Monolayers and Egress from Lamina Propria to Blood Circulation. Gastroenterology. 141(6): 2130-2139: 2011

Zhao R, Nakamura T, Fu Y, Lazar Z, Spector DL: Gene bookmarking accelerates the kinetics of post-mitotic transcriptional activation. Nat Cell Biol. 13(11): 1295-1304: 2011

Yamamoto M, Sakamoto N, Nakamura T, Itsui Y, Nakagawa M, Nishimura-Sakurai Y, Kakinuma S, Azuma S, Tsuchiya K, Kato T, Wakita T, Watanabe M: Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture. Hepatol Res. 41(3): 258-269: 2011

Zheng X, Tsuchiya K, Okamoto R, Iwasaki M, Kano Y, Sakamoto N, Nakamura T, Watanabe M: Suppression of Hath1 gene expression directly regulated by Hes1 via Notch signaling is associated with goblet cell depletion in ulcerative colitis. Inflamm Bowel Dis. 17(11): 2251-2260: 2011

Iwasaki M, Tsuchiya K, Okamoto R, Zheng X, Kano Y, Okamoto E, Okada E, Araki A, Suzuki S, Sakamoto N, Kitagaki K, Akashi T, Eishi Y, Nakamura T, Watanabe M: Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4. J Gastroenterol. 46(2): 191-201: 2011

Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M: Upregulated IL-7 Receptor a expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J Immunol. 186(4): 2623-2632: 2011

Prasanth KV, Camiolo M, Chan G, Tripathi V, Denis L, Nakamura T, Hubner M, Spector DL: Nuclear organization and dynamics of 7SK RNA in regulating gene expression. Mol Biol Cell. 21(23): 4184-4196: 2010

Bernard D, Prasanth KV, Tripathi V, Colasse S, Nakamura T, Xuan Z, Zhang MQ, Sedel F, Jourdren L, Coulpier F, Triller A, Spector DL, Bessis A: A long nuclear retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J. 29(18): 3082-3093: 2010

Kameyama K, Nemoto Y, Kanai T, Shinohara T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Hibi T, Watanabe M. Il-2 is positively involved in the development of colitogenic CD4(+) IL-7Ralpha (high) memory T cells in chronic colitis. Eur J Immunol. 40(9): 2423-2436: 2010

Akiyama J, Okamoto R, Iwasaki M, Zheng X, Yui S, Tsuchiya K, Nakamura T, Watanabe M. Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem Biophys Res Commun. 393(4): 662-667: 2010

Nemoto Y, Kanai T, Kameyama K, Shinohara T, Sakamoto N, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sudo T, Matsumoto S, Watanabe M. Long-Lived Colitogenic CD4 Memory T Cells Residing Outside the Intestine Participate in the Perpetuation of Chronic Colitis. J Immunol. 183(8):5059-5068: 2009

Totsuka T, Kanai T, Nemoto Y, Tomita T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Akiba H, Okumura K, Yagita H, Watanabe M. RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J Immunol. 182:6079-6087: 2009

Onizawa M, Nagaishi T, Kanai T, Nagano KI, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M. Signaling pathway via TNF-a/NF-kB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 296(4): G850-859: 2009

Murayama M, Okamoto R, Tsuchiya K, Akiyama J, Nakamura T, Sakamoto N, Kanai T, Watanabe M: Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. J Gastroenterol. 44(3):173-82: 2009

Okamoto R, Tsuchiya K, Nemoto Y, Akiyama J, Nakamura T, Kanai T, Watanabe M: Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 296(1): G23-35: 2009

Fujii T, Tomita T, Kanai T, Nemoto Y, Totsuka T, Sakamoto N, Nakamura T, Tsuchiya K, Okamoto R, Watanabe M: FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4(+) T cells in bone marrow. Eur J Immunol. 38(12):3290-303: 2008

Hozawa S, Nakamura T, Nakano M, Adachi M, Tanaka H, Takahashi Y, Mine T, Miyata N, Soma H, Hibi T: Induction of matrix metalloproteinase-1 gene transcription by tumor necrosis factor a via the p50/p50 homodimer of nuclear factor-B in activated human hepatic stellate cells. Liver Int. 28(10): 1418-1425: 2008

Tomita T, Kanai T, Nemoto Y, Fujii T, Nozaki K, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Watanabe M: Colitogenic CD4(+) effector-memory T cells actively recirculate in chronic colitic mice. Inflamm Bowel Dis. 14(12): 1630-1640: 2008

Yoshioka A, Okamoto R, Oshima S, Akiyama J, Tsuchiya K, Nakamura T, Kanai T, Watanabe M: Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells. Cytokine. 44(1): 57-64: 2008

Nemoto Y, Kanai T, Tohda S, Totsuka T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Fukuda T, Miura O, Yagita H, Watanabe M: Negative feedback regulation of colitogenic CD4(+) T cells by increased granulopoiesis. Inflamm Bowel Dis. 14(11): 1491-1503: 2008

Aragaki M, Tsuchiya K, Okamoto R, Yoshioka S, Nakamura T, Sakamoto N, Kanai T, Watanabe M: Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem Biophys Res Commun 368(4): 923-929: 2008

Nakamura T, Nagahori M, Kanai T, Watanabe M: Current pharmacologic therapies and emerging alternatives in the treatment of ulcerative colitis. Digestion 77 suppl 1: 36-41: 2008

Nakamura T, Tsuchiya K, Watanabe M: Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision. J Gastroenterol 42: 705-710: 2007.

Tsuchiya K, Nakamura T, Okamoto R, Kanai T, Watanabe M: Reciprocal targeting of Hath1 and beta-catenin by wnt glycogen synthase kinase 3 beta in human colon cancer. Gastroenterology. 132:208-220: 2007

Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology. 128:1851-1867: 2005

Namiki S, Nakamura T, Oshima S, Yamazaki M, Sekine Y, Tsuchiya K, Okamoto R, Kanai T, Watanabe M: IRF-1 mediates up-regulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett. 579:2781-2787: 2005

Okada E, Yamazaki M, Tanabe M, Takeuchi T, Nanno M, Oshima S, Okamoto R, Tsuchiya K, Nakamura T, Kanai T, Hibi T, Watanabe M: IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am J Physiol Gastrointest Liver Phyisol. 288:G745-754: 2005

Makita S, Kanai T, Oshima S, Uraushihara K, Totsuka T, Sawada T, Nakamura T, Koganei K, Fukushima T, Watanabe M: CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol. 173:3119-3130: 2004

Kanazawa N, Kurosaki M, Sakamoto N, Enomoto N, Itsui Y, Yamashiro T, Tanabe Y, Maekawa S, Nakagawa M, Chen CH, Kakinuma S, Oshima S, Nakamura T, Kato T, Wakita T, Watanabe M: Regulation of hepatitis C virus replication by interferon regulatory factor-1. J Virol. 78:9713-9720: 2004

Oshima S*, Nakamura T*, Namiki S, Okada E, Tsuchiya K, Okamoto R, Yamazaki M, Yokota T, Aida M, Yamaguchi Y, Kanai T, Handa H, Watanabe M: Interferon Regulatory Factor-1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol Cell Biol. 24:6298-6310: 2004

Kawamura T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Nakamura T, Higuchi T, Aiba Y, Tsubata T, Watanabe M: Ectopic CD40 Ligand Expression on B Cells Triggers Intestinal Inflammation. J Immunol. 172:6388-6397: 2004

Ishii K, Kanai T, Totsuka T, Uraushihara K, Ishikura T, Yamazaki M, Okamoto R, Araki A, Miyata T, Tezuka K, Nakamura T, Watanabe M: Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. J Gastroenterol Hepatol. 19:174-81: 2004.

Iiyama R, Kanai T, Uraushihara K, Ishikura T, Makita S, Totsuka T, Yamazaki M, Nakamura T, Miyata T, Yoshida H, Takeuchi O, Hoshino K, Takeda K, Ishikawa H, Akira S, Watanabe M: Normal development of the gut-associated lymphoid tissue except Peyer's patch in MyD88-deficient mice. Scand J Immunol. 58:620-7: 2003.

Kanai T, Totsuka T, Uraushihara K, Makita S, Nakamura T, Koganei K, Fukushima T, Akiba H, Yagita H, Okumura K, Machida U, Iwai H, Azuma M, Chen L, Watanabe M: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol. 171:4156-63: 2003.

Makita S, Kanai T, Matsumoto S, Iiyama R, Uraushihara K, Totsuka T, Yamazaki M, Nakamura T, Ishikawa H, Watanabe M: The role of cryptopatch-derived intraepithelial lymphocytes in the development of chronic ileocecitis. Scand J Immunol. 58:428-35: 2003.

Yamazaki M, Yajima T, Tanabe M, Fukui K, Okada E, Okamoto R, Oshima S, Nakamura T, Kanai T, Uehira M, Takeuchi T, Ishikawa H, Hibi T, Watanabe M: Mucosal T Cells Expressing High Levels of IL-7 Receptor Are Potential Targets for Treatment of Chronic Colitis. J Immunol 171: 1556-63: 2003.

Uraushihara K, Kanai T, Ko K, Totsuka T, Makita S, Iiyama R, Nakamura T, Watanabe M: Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells. J Immunol. 171: 708-16: 2003.

Kanai T, Uraushihara K, Totsuka T, Okazawa R, Hibi T, Oshima S, Miyata T, Nakamura T, Watanabe M: Macrophage-Derived IL-18 Targeting for the treatment of Crhon’s Disease. Current Drug Targets-Inflammation & Allergy 2: 131-136: 2003.

Ishikura T, Kanai T, Uraushihara K, Iiyama R, Makita S, Totsuka T, Yamazaki M, Sawada T, Nakamura T, Miyata T, Kitahora T, Hibi T, Hoshino T, Watanabe M: IL-18 overexpression exacerbates the development of colitis with markedly infiltrated macrophages in IL-18 transgenic mice. J Gastroenterol Hepatol 18: 960-969: 2003.

Iiyama R, Kanai T, Uraushihara K, Totsuka T, Nakamura T, Miyata T, Yagita H, Kushi A, Suzuki K, Tezuka K, Watanabe M: The role of Inducible Co-stimulator (ICOS)/B7 related protein-1 (B7RP-1) interaction in the functional development of Peyer’s patches. Immunol Letters 88: 63-70: 2003.

Watanabe S, Murakami T, Nakamura T, Morimoto C, Arai K: Human GM-CSF induces HIV-1 LTR by multiple signaling pathways. Biochimie 84: 633-642: 2002.

Nakamura T, Ouchida R, Kodama T, Kawashima T, Makino Y, Yoshikawa N, Watanabe S, Morimoto C, Kitamura T, Tanaka H: Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappaB activation in murine proB cell line Ba/F3 cells. J Biol Chem 277: 6254-6265: 2002.

Miura T, Ouchida R, Yoshikawa N, Okamoto K, Makino Y, Nakamura T, Morimoto C, Makino I, Tanaka H: Functional modulation of the glucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid. J Biol Chem 276: 47371-47378: 2001.

Iida T, Makino Y, Okamoto K, Yoshikawa N, Makino I, Nakamura T, Tanaka H: Functional modulation of the mineralocorticoid receptor by cis-diamminedichloroplatinum (II). Kidney Int 58: 1450-60: 2000.

Kurose I, Saito H, Miura S, Ebinuma H, Higuchi H, Watanabe W, Zeki S, Nakamura T, Takaishi M, Ishii H: CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells. J Clin Invest 99: 867-78: 1997.

Kurose I, Higuchi H, Miura S, Saito H, Watanabe N, Hokari R, Hirokawa M, Takaishi M, Zeki S, Nakamura T, Ebinuma H, Kato S, Ishii H: Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. Hepatology 25: 368-78: 1997.

Kurose I, Higuchi H, Watanabe N, Miura S, Tomita K, Yonei Y, Takaishi M, Zeki S, Nakamura T, Saito H, Kato S, Ishii H: CD18/ICAM-1-dependent nitric oxide production of Kupffer cells as a cause of mitochondrial dysfunction in hepatoma cells: influence of chronic alcohol feeding. Free Radic Biol Med 22: 229-39: 1997.

Takaishi M, Kurose I, Higuchi H, Watanabe N, Nakamura T, Zeki S, Nishida J, Kato S, Miura S, Mizuno Y, Kvietys PR, Granger DN, Ishii H: Ethanol-induced leukocyte adherence and albumin leakage in rat mesenteric venules: role of CD18/intercellular adhesion molecule-1. Alcohol Clin Exp Res 20: 347-349: 1996.

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