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研究業績詳細

CHARVAT Hadrien（シャルヴァアドリアン）

研究テーマ	生物統計学、疫学
研究業績（論文）	「原著論文」 77. Charvat H, Fukui K, Matsuda T, Katanoda K, Ito Y. Impact of cancer and other causes of death on mortality of cancer patients: a study based on Japanese population-based registry data. Int J Cancer 2023 (doi: 10.1002/ijc.34610). 76. Irie T, Yamada H, Takeuchi C, Liu YY, Charvat H, Shimazu T, Ando T, Maekita T, Abe S, Takamaru H, Kodama M, Murakami K, Sugimoto K, Sakamoto K, Ushijima T. The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa. Gastric Cancer 2023 (doi: 10.1007/s10120-023-01399-w). 75. Mafra A, Bardot A, Charvat H, Weiderpass E, Soerjomataram I, Fregnani JHTG. Cancer survival in the northwestern of Sao Paulo State, Brazil: a population-based study. Cancer Epidemiol 2023;83:102339 (doi: 10.1016/j.canep.2023.102339). 74. Goungounga JA, Graffeo N, Charvat H, Giorgi R. Correcting for heterogeneity and non-comparability bias in multicenter clinical trials with a rescaled random-effect excess hazard model. Biom J 2023;65(4):e2100210 (doi: 10.1002/bimj.202100210). 73. Charvat H, Gatellier L. International variations in age-specific incidence rates of central nervous system (CNS) neoplasms in children and adolescents. Jpn J Clin Oncol 2023;53(3):284-285 (doi: 10.1093/jjco/hyad015). 72. Charvat H. Using the Lambert function to estimate shared frailty models with a normally distributed random intercept. Am Stat 2023;77(1):41-50 (doi:10.1080/00031305.2022.2110939). 71. Marant Micallef C, Charvat H, Houot MT, Vignat J, Straif K, Paul A, El Yamani M, Pilorget C, Soerjomataram I. Estimated number of cancers attributable to occupational exposures in France in 2017: an update using a new method for improved estimates. J Expo Sci Environ Epidemiol 2023;33(1):125-131 (doi: 10.1038/s41370-021-00353-1). 70. Vaccarella S, Georges D, Bray F, Ginsburg O, Charvat H, Martikainen P, Brønnum-Hansen H, Deboosere P, Bopp M, Leinsalu M, Artnik B, Lorenzoni V, De Vries E, Marmot M, Vineis P, Mackenbach J, Nusselder W. Socioeconomic inequalities in cancer mortality between and within countries in Europe: a population-based study. Lancet Reg Health Eur 2023;25:100551 (doi: 10.1016/j.lanepe.2022.100551). 70. Nakata K, Charvat H. International variations in carcinoma and melanoma incidence in children and adolescents. Jpn J Clin Oncol 2022;52(12):1452-1454 (doi: 10.1093/jjco/hyac179). 68. Matsuda T, Charvat H. International variations in germ cell tumours incidence in children and adolescents. Jpn J Clin Oncol 2022 (doi: 10.1093/jjco/hyac163). 67. Murai U, Sawada N, Charvat H, Inoue M, Yasuda N, Yamagishi K, Tsugane S; JPHC Study Group. Soy product intake and risk of incident disabling dementia: the JPHC Disabling Dementia Study. Eur J Nutr 2022;61(8):4045-4057 (doi: 10.1007/s00394-022-02937-5). 66. Charvat H, Nakata K. International variations in renal tumours incidence in children and adolescents. Jpn J Clin Oncol 2022;52(7):795-797 (doi: 10.1093/jjco/hyac104). 65. Kohls M, Freisling H, Charvat H, Soerjomataram I, Viallon V, Davila-Batista V, Kaaks R, Turzanski-Fortner R, Aleksandrova K, Schulze MB, Dahm CC, Tilma Vistisen H, Rostgaard-Hansen AL, Tjønneland A, Bonet C, Sánchez MJ, Colorado-Yohar S, Masala G, Palli D, Krogh V, Ricceri F, Rolandsson O, Lu SSM, Tsilidis KK, Weiderpass E, Gunter MJ, Ferrari P, Berger U, Arnold M. Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort study. BMC Cancer 2022;22(1):546 (doi: 10.1186/s12885-022-09589-y). 64. Li M, Zhang L, Charvat H, Callister ME, Sasieni P, Christodoulou E, Kaaks R, Johansson M, Carvalho AL, Vaccarella S, Robbins HA. The influence of postscreening follow-up time and participant characteristics on estimates of overdiagnosis from lung cancer screening trials. Int J Cancer 2022;151(9):1491-1501 (doi: 10.1002/ijc.34167). 63. Ihira H, Sawada N, Inoue M, Yasuda N, Yamagishi K, Charvat H, Iwasaki M, Tsugane S. Association between physical activity and risk of disabling dementia in Japan. JAMA Netw Open 2022;5(3):e224590 (doi: 10.1001/jamanetworkopen.2022.4590). 62. Li M, Chen WJ, Yang J, Charvat H, Xie SH, Li T, Ling W, Lu YQ, Liu Q, Hong MH, Cao SM. Association between solid fuel use and seropositivity against Epstein-Barr virus in a high-risk area for nasopharyngeal carcinoma. Environ Pollut 2022;304:119184 (doi: 10.1016/j.envpol.2022.119184). 61. Matsuda T, Charvat H. International variations in lymphoma incidence in children and adolescents. Jpn J Clin Oncol 2022;52(4):399-401 (doi: 10.1093/jjco/hyac037). 60. Sawada N, Nakaya T, Kashima S, Yorifuji T, Hanibuchi T, Charvat H, Yamaji T, Iwasaki M, Inoue M, Iso H, Tsugane S. Long-term exposure to fine particle matter and all-cause mortality and cause-specific mortality in Japan: the JPHC study. BMC Public Health 2022;22(1):466 (doi: 10.1186/s12889-022-12829-2). 59. Charvat H, Freisling H, Noh H, Gaudet MM, Gunter MJ, Cross AJ, Tsilidis KK, Tjonneland A, Katzke V, Bergmann M, Agnoli C, Rylander C, Skeie G, Jakszyn P, Rosendahl AH, Sund M, Severi G, Tsugane S, Sawada N, Brenner H, Adami HO, Weiderpass E, Soerjomataram I, Arnold M. Excess body fatness during early yo mid-adulthood and survival from colorectal and breast cancer: a pooled analysis of five international cohort studies. Cancer Epidemiol Biomarkers Prev 2022;31(2):325-333 (doi: 10.1158/1055-9965.EPI-21-0688). 58. Ma E, Shimazu T, Song M, Charvat H, Sawada N, Yamaji T, Inoue M, Camargo MC, Kemp TJ, Pfeiffer RM, Pinto LA, Rabkin CS, Tsugane S. Circulating inflammation markers and pancreatic cancer risk: a prospective case-cohort study in Japan. Cancer Epidemiol Biomarkers Prev 2022;31(1):236-241 (doi: 10.1158/1055-9965.EPI-21-0808). 57. Miranda-Filho A, Charvat H, Bray F, Migowski A, Cheung LC, Vaccarella S, Johansson M, Carvalho AL, Robbins HA. A modelling analysis to compare eligibility strategies for lung cancer screening in Brazil. EClinicalMedicine 2021;42:101176 (doi: 10.1016/j.eclinm.2021.101176). 56. Rumgay H, Shield K, Charvat H, Ferrari P, Sornpaisarn B, Obot I, Islami F, Lemmens VEPP, Rehm J, Soerjomataram I. Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study. Lancet Oncol 2021;22(8):1071-1080 (doi: 10.1016/S1470-2045(21)00279-5). 55. Charvat H, Belot A. mexhaz: an R package for fitting flexible hazard-based regression models for overall and excess mortality with a random effect. J Stat Softw 2021;98(14):1-36 (doi: 10.18637/jss.v098.i14). 54. Charvat H, Saito E. Age-specific larynx cancer incidence rate in the world. Jpn J Clin Oncol 2021;51(7):1181-1182 (doi: 10.1093/jjco/hyab097). 53. Matsuda T, Charvat H. Age-specific testis cancer incidence rate in the world. Jpn J Clin Oncol 2021;51(6):1019-1020 (doi: 10.1093/jjco/hyab080). 52. Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D. Age disparities in lung cancer survival in New Zealand: the role of patient and clinical factors. Lung Cancer 2021;157:92-99 (doi: 10.1016/j.lungcan.2021.05.015). 51. Camargo MC, Song M, Sawada N, Inoue M, Shimazu T, Charvat H, Pfeiffer RM, Yamaji T, Tsugane S, Rabkin CS. Prediagnostic circulating inflammation-related biomarkers and gastric cancer: a case-cohort study in Japan. Cytokine 2021;144:155558 (doi: 10.1016/j.cyto.2021.155558). 50. Bonjour M, Charvat H, Franco EL, Pineros M, Clifford GM, Bray F, Baussano I. Global estimates of expected and preventable cervical cancers among girls born between 2005 and 2014: a birth cohort analysis. Lancet Public Health 2021;6(7):e510-e521 (doi: 10.1016/S2468-2667(21)00046-3). 49. Pilleron S, Maringe C, Charvat H, Atkinson J, Morris EJA, Sarfati D. The impact of timely cancer diagnosis on age disparities in colon cancer survival. J Geriatr Oncol 2021;12(7):1044-1051 (doi: 10.1016/j.jgo.2021.04.003). 48. Marant Micallef C, Paul A, Charvat H, Vignat J, Houot M, Pilorget C, Straif K, El Yamani M, Soerjomataram I. An innovative method to estimate lifetime prevalence of carcinogenic occupational circumstances: the example of painters and workers of the rubber manufacturing industry in France. J Expo Sci Environ Epidemiol 2021;31(4):769-776 (doi: 10.1038/s41370-020-00272-7). 47. Pilleron S, Charvat H, Araghi M, Arnold M, Fidler-Benaoudia MM, Bardot A, Guren MG, Tervonen H, Little A, O’Connell DL, Gavin A, De P, Aagaard Thomsen L, Moller B, Jackson C, Bucher O, Walsh PM, Vernon S, Bray F, Soerjomataram I. Age disparities in stage-specific colon cancer survival across seven countries: an ICBP SURVMARK-2 population-based study. Int J Cancer 2021;148(7):1575-1585 (doi: 10.1002/ijc.33326). 46. Nozue M, Shimazu T, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented soy products intake and risk of cardiovascular disease and total cancer incidence: the Japan Public Health Center-based Prospective Study. Eur J Clin Nutr 2021;75(6):954-968 (doi: 10.1038/s41430-020-00732-1). 45. Li M, Sun Y, Yang J, de Martel C, Charvat H, Clifford GM, Vaccarella S, Wang L. Time trends and other sources of variation in Helicobacter pylori infection in mainland China: a systematic review and meta-analysis. Helicobacter 2020;25(5):e12729 (doi: 10.1111/hel.12729). 44. Miranda-Filho A, Bray F, Charvat H, Rajaraman S, Soerjomataram I. The world cancer patient population (WCPP): an updated standard for international comparisons of population-based survival. Cancer Epidemiol 2020;69:101802 (doi: 10.1016/j.canep.2020.101802). 43. Charvat H, Shimazu T, Inoue M, Iwasaki M, Sawada N, Yamaji T, Tsugane S; JPHC Study Group. Estimation of the performance of a risk prediction model for gastric cancer occurrence in Japan: evidence from a small external population. Cancer Epidemiol 2020;67:101766 (doi: 10.1016/j.canep.2020.101766). 42. Van Alsten SC, Rabkin CS, Sawada N, Shimazu T, Charvat H, Yamaji T, Inoue M, Kemp TJ, Pinto LA, Camargo MC, Tsugane S, Song M. Metabolic syndrome, physical activity, and inflammation: a cross-sectional analysis of 110 circulating biomarkers in Japanese adults. Cancer Epidemiol Biomarkers Prev 2020;29(8):1639-1646 (doi: 10.1158/1055-9965.EPI-19-1513). 41. Budhathoki S, Iwasaki M, Yamaji T, Hamada GS, Miyajima NT, Zampieri JC, Sharma S, Pakseresht M, Kolahdooz F, Ishihara J, Takachi R, Charvat H, Le Marchand L, Tsugane S. Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians. Eur J Cancer Prev 2020;29(1):7-14 (doi: 10.1097/CEJ.0000000000000506). 40. Noh H, Charvat H, Freisling H, Olafsdottir GH, Olafsdottir EJ, Tryggvadottir L, Arnold M, Soerjomataram I. Cumulative exposure to premenopausal obesity and risk of postmenopausal cancer: a population-based study in Icelandic women. Int J Cancer 2020;147(3):793-802 (doi: 10.1002/ijc.32805). 39. Aversa J, Song M, Shimazu T, Inoue M, Charvat H, Yamaji T, Sawada N, Pfeiffer RM, Karimi P, Dawsey SM, Rabkin CS, Tsugane S, Camargo MC. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: a case-cohort study in Japan. Int J Cancer 2020;147(3):686-691 (doi: 10.1002/ijc.32763). 38. Oze I, Charvat H, Matsuo K, Ito H, Tamakoshi A, Nagata C, Wada K, Sugawara Y, Sawada N, Yamaji T, Naito M, Tanaka K, Shimazu T, Mizoue T, Tsugane S, Inoue M. Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? Cancer Med 2019;8(14):6414-6425 (doi: 10.1002/cam4.2514). 37. Hugues A, Di Marco J, Ribault S, Ardaillon H, Janiaud P, Xue Y, Zhu J, et al. Limited evidence of physical therapy on balance after stroke: a systematic review and meta-analysis. PLos One 2019;14(8):e0221700 (doi: 10.1371/journal.pone.0221700). 36. Budhathoki S, Sawada N, Iwasaki M, Yamaji T, Goto A, Kotemori A, Ishihara J, Takachi R, Charvat H, Mizoue T, Iso H, Tsugane S; Japan Public Health Center-based Prospective Study Group. Association of animal and plant protein intake with all-cause and cause-specific mortality. JAMA Intern Med 2019;179(11):1509-1518 (doi: 10.1001/jamainternmed.2019. 2806). 35. Kipourou DK, Charvat H, Rachet B, Belot A. Estimation of the adjusted cause-specific cumulative probability using flexible regression models for the cause-specific hazards. Stat Med 2019;38(20):3896-3910 (doi: 10.1002/sim.8209). 34. Arnold M, Charvat H, Freisling H, Noh H, Adami HO, Soerjomataram I, Weiderpass E. Adulthood overweight and survival from breast and colorectal cancer in Swedish women. Cancer Epidemiol Biomarkers Prev 2019;28(9):1518-1524 (doi: 10.1158/1055-9965.EPI-19-0075). 33. Remontet L, Uhry Z, Bossard N, Iwaz J, Belot A, Danieli C, Charvat H, Roche L; CENSUR Working Survival Group. Flexible and structured survival model for a simultaneous estimation of non-linear and non-proportional effects and complex interactions between continuous variables: performance of this multidimensional penalized spline approach in net survival trend analysis. Stat Methods Med Res 2019;28(8):2368-2384 (doi: 10.1177/0962280218779408). 32. Camargo MC, Song M, Shimazu T, Charvat H, Yamaji T, Sawada N, Kemp TJ, Pfeiffer RM, Hildesheim A, Pinto LA, Tsugane S, Rabkin CS. Circulating inflammation markers and risk of gastric and esophageal cancers: a case-cohort study within the Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev 2019;28(4):829-832 (doi: 10.1158/1055-9965.EPI-18-1157). 31. Ikeda A, Charvat H, Shigemura J, Kales SN, Tanigawa T. Longitudinal trends in disaster-related insomnia among Fukushima nuclear plant workers: the Fukushima Nuclear Energy Workers’ Support Project Study. Sleep 2019;42(5) (doi: 10.1093/sleep/zsz043). 30. Pilleron S, Soerjomataram I, Charvat H, Chokunoga E, Somdyala NIM, Wabinga H, Korir A, Bray F, Jemal A, Maxwell Parkin D. Cancer incidence in older adults in selected regions of sub-Saharan Africa, 2008-2012. Int J Cancer 2019;144(8):1824-1833 (doi: 10.1002/ijc.31880). 29. Hidaka A, Budhathoki S, Yamaji T, Sawada N, Tanaka-Mizuno S, Kuchiba A, Charvat H, Goto A, Shimazu T, Inoue M, Noda M, Tsugane S, Iwasaki M; JPHC Study Group. Plasma C-peptide and glycated albumin and subsequent risk of cancer: from a large prospective case-cohort study in Japan. Int J Cancer 2019;144(4):718-729 (doi: 10.1002/ijc.31847). 28. Mori N, Shimazu T, Charvat H, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Goto A, Takachi R, Ishihara J, Noda M, Iso H, Tsugane S; JPHC Study Group. Cruciferous vegetable intake and mortality in middle-aged adults: a prospective cohort study. Clin Nutr 2019;38(2):631-643 (doi: 10.1016/j.clnu.2018.04.012). 27. Song M, Sasazuki S, Camargo MC, Shimazu T, Charvat H, Yamaji T, Sawada N, Kemp TJ, Pfeiffer RM, Hildesheim A, Pinto LA, Rabkin CS, Tsugane S. Circulating inflammatory markers and colorectal cancer risk: a prospective case-cohort study in Japan. Int J Cancer 2018;143(11):2767-2776 (doi: 10.1002/ijc.31821). 26. Belot A, Remontet L, Rachet B, Dejardin O, Charvat H, Bara S, Guizard AV, Roche L, Launoy G, Bossard N. Describing the association between socioeconomic inequalities and cancer survival: methodological guidelines and illustration with population-based data. Clinical Epidemiol 2018;10:561-573 (doi: 10.2147/CLEP.S150848). 25. Budhathoki S, Hidaka A, Yamaji T, Sawada N, Tanaka-Mizuno S, Kuchiba A, Charvat H, Goto A, Kojima S, Sudo N, Shimazu T, Sasazuki S, Inoue M, Tsugane S, Iwasaki M; Japan Public Health Center-based Prospective Study Group. Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort. BMJ 2018;360:k671 (doi: 10.1136/bmj.k671). 24. Yamashita S, Kishino T, Takahashi T, Shimazu T, Charvat H, Kakugawa Y, Nakajima T, Lee YC, Iida N, Maeda M, Hattori N, Takeshima H, Nagano R, Oda I, Tsugane S, Wu MS, Ushijima T. Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues. Proc Natl Acad Sci USA 2018;115(6):1328-1333 (doi: 10.1073/pnas.1717340115). 23. Charvat H, Sasazuki S, Shimazu T, Budhathoki S, Inoue M, Iwasaki M, Sawada N, Yamaji T, Tsugane S; JPHC Study Group. Development of a risk prediction model for lung cancer: the Japan Public Health Center-based Prospective Study. Cancer Sci 2018;109(3):854-862 (doi: 10.1111/cas.13509). 22. Saito E, Inoue M, Sawada N, Charvat H, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Mizoue T, Iso H, Tsugane S. Impact of alcohol intake and drinking patterns on mortality from all causes and major causes of death in a Japanese population. J Epidemiol 2018;28(3):140-148 (doi: 10.2188/jea.JE20160200). 21. Taniyama Y, Katanoda K, Charvat H, Hori M, Ohno Y, Sasazuki S, Tsugane S. Estimation of lifetime cumulative incidence and mortality risk of gastric cancer. Jpn J Clin Oncol 2017;47(11):1097-1102 (doi: 10.1093/jjco/hyx128). 20. Nozue M, Shimazu T, Sasazuki S, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented soy product intake is inversely associated with the development of high blood pressure: the Japan Public Health Center-based Prospective Study. J Nutr 2017;147(9):1749-1756 (doi: 10.3945/jn.117.250282). 19. Svensson T, Inoue M, Sawada N, Charvat H, Mimura M, Tsugane S; JPHC Study Group. High serum total cholesterol is associated with suicide mortality in Japanese women. Acta Psychiatr Scand 2017;136(3):259-268 (doi: 10.1111/acps.12758). 18. Danieli C, Bossard N, Roche L, Belot A, Uhry Z, Charvat H, Remontet L. Performance of two formal tests based on martingales residuals to check the proportional hazard assumption and the functional form of the prognostic factors in flexible parametric excess hazard models. Biostatistics 2017;18(3):505-520 (doi: 10.1093/biostatistics/kxw056). 17. Ikeda A, Tanigawa T, Charvat H, Wada H, Shigemura J, Kawachi I. Longitudinal effects of disaster-related experiences on mental health among Fukushima nuclear plant workers: the Fukushima NEWS Project Study. Psychological Medicine 2017:47(11):1936-1946 (doi: 10.1017/S0033291717000320). 16. Charvat H, Remontet L, Bossard N, Roche L, Dejardin O, Rachet B, Launoy G, Belot A; CENSUR Survival Working Group. A multilevel excess hazard model to estimate net survival on hierarchical data allowing for non-linear and non-proportional effects of covariates. Stat Med 2016;35(18):3066-3084 (doi: 10.1002/sim.6881). 15. Goto A, Noda M, Inoue M, Goto M, Charvat H. Increasing number of people with diabetes in Japan: is this trend real? Intern Med 2016;55(14):1827-1830 (doi: 10.2169/internalmedicine.55.6475). 14. Hidaka A, Sasazuki S, Matsuo K, Ito H, Charvat H, Sawada N, Shimazu T, Yamaji T, Iwasaki M, Inoue M, Tsugane S; JPHC Study Group. CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: a nested case-control study within a large-scale population-based prospective study. Int J Cancer 2016;139(4):759-768 (doi: 10.1002/ijc.30130). 13. Saito E, Charvat H, Goto A, Matsuda T, Noda M, Sasazuki S, Inoue M. Burden of cancer associated with type 2 diabetes mellitus in Japan, 2010-2030. Cancer Sci 2016;107(4):521-527 (doi: 10.1111/cas.12902). 12. Svensson T, Inoue M, Sawada N, Yamagishi K, Charvat H, Saito I, Kokubo Y, Iso H, Kawamura N, Shibuya K, Mimura M, Tsugane S; JPHC Study Group. Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective study. Eur Heart J 2016;37(11):890-899 (doi: 10.1093/eurheartj/ehv724). 11. Svensson T, Inoue M, Sawada N, Charvat H, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kawamura N, Shibuya K, Mimura M, Tsugane S; JPHC Study Group. Coping strategies and cancer incidence and mortality: the Japan Public Health Center-based prospective study. Cancer Epidemiol 2016;40:126-133 (doi: 10.1016/j.canep.2015.12.003). 10. Charvat H, Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, Tsugane S; JPHC Study Group. Prediction of the 10-year probability of gastric cancer occurrence in the Japanese population: the JPHC study cohort II. Int J Cancer 2016;138(2):320-331 (doi: 10.1002/ijc.29705). 9. Shimazu T, Asada K, Charvat H, Kusano C, Otake Y, Kakugawa Y, Watanabe H, Gotoda T, Ushijima T, Tsugane S. Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study. Carcinogenesis 2015;36(11):1291-1298 (doi: 10.1093/carcin/bgv125). 8. Charvat H, Goto A, Goto M, Inoue M, Heianza Y, Arase Y, Sone H, Nakagami T, Song X, Qiao Q, Tuomilehto J, Tsugane S, Noda M, Inoue M. Impact of population aging on trends in diabetes prevalence: a meta-regression analysis of 160,000 Japanese adults. J Diabetes Investig 2015;6(5):533-542 (doi: 10.1111/jdi.12333). 7. Kawabata-Shoda E, Charvat H, Ikeda A, Inoue M, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kimura H, Tsugane S, Masuda S. Trends in cancer prognosis in a population-based cohort survey: can recent advances in cancer therapy affect the prognosis? Cancer Epidemiol 2015;39(1):97-103 (doi: 10.1016/j.canep.2014.11.008). 6. Svensson T, Inoue M, Charvat H, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Ikeda A, Kawamura N, Mimura M, Tsugane S, for the JPHC Study Group. Coping behaviors and suicide in the middle-aged and older general Japanese population: the Japan Public Health Center-based Prospective Study. Ann Epidemiol 2014;24(3):199-205 (doi: 10.1016/j.annepidem.2013.12.006). 5. Charvat H, Bossard N, Daubisse L, Binder F, Belot A, Remontet L. Probabilities of dying from cancer and other causes in French cancer patients based on an unbiased estimator of net survival: a study of five common cancers. Cancer Epidemiol 2013;37(6):857-863 (doi: 10.1016/j.canep.2013.08.006). 4. Charvat H, Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, Tsugane S, for the JPHC Study Group. Impact of five modifiable lifestyle habits on the probability of cancer occurrence in the Japanese population: results from a large cohort study. Prev Med 2013;57(5):685-689 (doi: 10.1016/j.ypmed.2013.08.030). 3. Sasazuki S, Charvat H, Hara A, Wakai K, Nagata C, Nakamura K, Tsuji I, Sugawara Y, Tamakoshi A, Matsuo K, Oze I, Mizoue T, Tanaka K, Inoue M, Tsugane S; for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Diabetes mellitus and cancer risk: pooled analysis of eight cohort studies in Japan. Cancer Sci 2013;104(11):1499-1507 (doi: 10.1111/cas.12241). 2. Charvat H, Belot A, Gueyffier F, Roy P. Expected impact of a public health intervention in the presence of synergistic risk factors. J Clin Epidemiol 2013;66(4):445-452 (doi: 10.1016/j.jclinepi.2012.11.004). 1. Charvat H, Ayzac L, Girard R, Gardes S, Ecochard R. Detecting related cases of bloodstream infections using time interval distribution modelling. J Hosp Inf 2010;74(3):250-257 (doi: 10.1016/j.jhin.2009.08.012). 「コンピュータソフト」 mexhaz (R package) [https://cran.r-project.org/web/packages/mexhaz/index.html]

研究テーマ

生物統計学、疫学

研究業績（論文）

「原著論文」

77. Charvat H, Fukui K, Matsuda T, Katanoda K, Ito Y. Impact of cancer and other causes of death on mortality of cancer patients: a study based on Japanese population-based registry data. Int J Cancer 2023 (doi: 10.1002/ijc.34610).

76. Irie T, Yamada H, Takeuchi C, Liu YY, Charvat H, Shimazu T, Ando T, Maekita T, Abe S, Takamaru H, Kodama M, Murakami K, Sugimoto K, Sakamoto K, Ushijima T. The methylation level of a single cancer risk marker gene reflects methylation burden in gastric mucosa. Gastric Cancer 2023 (doi: 10.1007/s10120-023-01399-w).

75. Mafra A, Bardot A, Charvat H, Weiderpass E, Soerjomataram I, Fregnani JHTG. Cancer survival in the northwestern of Sao Paulo State, Brazil: a population-based study. Cancer Epidemiol 2023;83:102339 (doi: 10.1016/j.canep.2023.102339).

74. Goungounga JA, Graffeo N, Charvat H, Giorgi R. Correcting for heterogeneity and non-comparability bias in multicenter clinical trials with a rescaled random-effect excess hazard model. Biom J 2023;65(4):e2100210 (doi: 10.1002/bimj.202100210).

73. Charvat H, Gatellier L. International variations in age-specific incidence rates of central nervous system (CNS) neoplasms in children and adolescents. Jpn J Clin Oncol 2023;53(3):284-285 (doi: 10.1093/jjco/hyad015).

72. Charvat H. Using the Lambert function to estimate shared frailty models with a normally distributed random intercept. Am Stat 2023;77(1):41-50 (doi:10.1080/00031305.2022.2110939).

71. Marant Micallef C, Charvat H, Houot MT, Vignat J, Straif K, Paul A, El Yamani M, Pilorget C, Soerjomataram I. Estimated number of cancers attributable to occupational exposures in France in 2017: an update using a new method for improved estimates. J Expo Sci Environ Epidemiol 2023;33(1):125-131 (doi: 10.1038/s41370-021-00353-1).

70. Vaccarella S, Georges D, Bray F, Ginsburg O, Charvat H, Martikainen P, Brønnum-Hansen H, Deboosere P, Bopp M, Leinsalu M, Artnik B, Lorenzoni V, De Vries E, Marmot M, Vineis P, Mackenbach J, Nusselder W. Socioeconomic inequalities in cancer mortality between and within countries in Europe: a population-based study. Lancet Reg Health Eur 2023;25:100551 (doi: 10.1016/j.lanepe.2022.100551).

70. Nakata K, Charvat H. International variations in carcinoma and melanoma incidence in children and adolescents. Jpn J Clin Oncol 2022;52(12):1452-1454 (doi: 10.1093/jjco/hyac179).

68. Matsuda T, Charvat H. International variations in germ cell tumours incidence in children and adolescents. Jpn J Clin Oncol 2022 (doi: 10.1093/jjco/hyac163).

67. Murai U, Sawada N, Charvat H, Inoue M, Yasuda N, Yamagishi K, Tsugane S; JPHC Study Group. Soy product intake and risk of incident disabling dementia: the JPHC Disabling Dementia Study. Eur J Nutr 2022;61(8):4045-4057 (doi: 10.1007/s00394-022-02937-5).

66. Charvat H, Nakata K. International variations in renal tumours incidence in children and adolescents. Jpn J Clin Oncol 2022;52(7):795-797 (doi: 10.1093/jjco/hyac104).

65. Kohls M, Freisling H, Charvat H, Soerjomataram I, Viallon V, Davila-Batista V, Kaaks R, Turzanski-Fortner R, Aleksandrova K, Schulze MB, Dahm CC, Tilma Vistisen H, Rostgaard-Hansen AL, Tjønneland A, Bonet C, Sánchez MJ, Colorado-Yohar S, Masala G, Palli D, Krogh V, Ricceri F, Rolandsson O, Lu SSM, Tsilidis KK, Weiderpass E, Gunter MJ, Ferrari P, Berger U, Arnold M. Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort study. BMC Cancer 2022;22(1):546 (doi: 10.1186/s12885-022-09589-y).

64. Li M, Zhang L, Charvat H, Callister ME, Sasieni P, Christodoulou E, Kaaks R, Johansson M, Carvalho AL, Vaccarella S, Robbins HA. The influence of postscreening follow-up time and participant characteristics on estimates of overdiagnosis from lung cancer screening trials. Int J Cancer 2022;151(9):1491-1501 (doi: 10.1002/ijc.34167).

63. Ihira H, Sawada N, Inoue M, Yasuda N, Yamagishi K, Charvat H, Iwasaki M, Tsugane S. Association between physical activity and risk of disabling dementia in Japan. JAMA Netw Open 2022;5(3):e224590 (doi: 10.1001/jamanetworkopen.2022.4590).

62. Li M, Chen WJ, Yang J, Charvat H, Xie SH, Li T, Ling W, Lu YQ, Liu Q, Hong MH, Cao SM. Association between solid fuel use and seropositivity against Epstein-Barr virus in a high-risk area for nasopharyngeal carcinoma. Environ Pollut 2022;304:119184 (doi: 10.1016/j.envpol.2022.119184).

61. Matsuda T, Charvat H. International variations in lymphoma incidence in children and adolescents. Jpn J Clin Oncol 2022;52(4):399-401 (doi: 10.1093/jjco/hyac037).

60. Sawada N, Nakaya T, Kashima S, Yorifuji T, Hanibuchi T, Charvat H, Yamaji T, Iwasaki M, Inoue M, Iso H, Tsugane S. Long-term exposure to fine particle matter and all-cause mortality and cause-specific mortality in Japan: the JPHC study. BMC Public Health 2022;22(1):466 (doi: 10.1186/s12889-022-12829-2).

59. Charvat H, Freisling H, Noh H, Gaudet MM, Gunter MJ, Cross AJ, Tsilidis KK, Tjonneland A, Katzke V, Bergmann M, Agnoli C, Rylander C, Skeie G, Jakszyn P, Rosendahl AH, Sund M, Severi G, Tsugane S, Sawada N, Brenner H, Adami HO, Weiderpass E, Soerjomataram I, Arnold M. Excess body fatness during early yo mid-adulthood and survival from colorectal and breast cancer: a pooled analysis of five international cohort studies. Cancer Epidemiol Biomarkers Prev 2022;31(2):325-333 (doi: 10.1158/1055-9965.EPI-21-0688).

58. Ma E, Shimazu T, Song M, Charvat H, Sawada N, Yamaji T, Inoue M, Camargo MC, Kemp TJ, Pfeiffer RM, Pinto LA, Rabkin CS, Tsugane S. Circulating inflammation markers and pancreatic cancer risk: a prospective case-cohort study in Japan. Cancer Epidemiol Biomarkers Prev 2022;31(1):236-241 (doi: 10.1158/1055-9965.EPI-21-0808).

57. Miranda-Filho A, Charvat H, Bray F, Migowski A, Cheung LC, Vaccarella S, Johansson M, Carvalho AL, Robbins HA. A modelling analysis to compare eligibility strategies for lung cancer screening in Brazil. EClinicalMedicine 2021;42:101176 (doi: 10.1016/j.eclinm.2021.101176).

56. Rumgay H, Shield K, Charvat H, Ferrari P, Sornpaisarn B, Obot I, Islami F, Lemmens VEPP, Rehm J, Soerjomataram I. Global burden of cancer in 2020 attributable to alcohol consumption: a population-based study. Lancet Oncol 2021;22(8):1071-1080 (doi: 10.1016/S1470-2045(21)00279-5).

55. Charvat H, Belot A. mexhaz: an R package for fitting flexible hazard-based regression models for overall and excess mortality with a random effect. J Stat Softw 2021;98(14):1-36 (doi: 10.18637/jss.v098.i14).

54. Charvat H, Saito E. Age-specific larynx cancer incidence rate in the world. Jpn J Clin Oncol 2021;51(7):1181-1182 (doi: 10.1093/jjco/hyab097).

53. Matsuda T, Charvat H. Age-specific testis cancer incidence rate in the world. Jpn J Clin Oncol 2021;51(6):1019-1020 (doi: 10.1093/jjco/hyab080).

52. Pilleron S, Maringe C, Charvat H, Atkinson J, Morris E, Sarfati D. Age disparities in lung cancer survival in New Zealand: the role of patient and clinical factors. Lung Cancer 2021;157:92-99 (doi: 10.1016/j.lungcan.2021.05.015).

51. Camargo MC, Song M, Sawada N, Inoue M, Shimazu T, Charvat H, Pfeiffer RM, Yamaji T, Tsugane S, Rabkin CS. Prediagnostic circulating inflammation-related biomarkers and gastric cancer: a case-cohort study in Japan. Cytokine 2021;144:155558 (doi: 10.1016/j.cyto.2021.155558).

50. Bonjour M, Charvat H, Franco EL, Pineros M, Clifford GM, Bray F, Baussano I. Global estimates of expected and preventable cervical cancers among girls born between 2005 and 2014: a birth cohort analysis. Lancet Public Health 2021;6(7):e510-e521 (doi: 10.1016/S2468-2667(21)00046-3).

49. Pilleron S, Maringe C, Charvat H, Atkinson J, Morris EJA, Sarfati D. The impact of timely cancer diagnosis on age disparities in colon cancer survival. J Geriatr Oncol 2021;12(7):1044-1051 (doi: 10.1016/j.jgo.2021.04.003).

48. Marant Micallef C, Paul A, Charvat H, Vignat J, Houot M, Pilorget C, Straif K, El Yamani M, Soerjomataram I. An innovative method to estimate lifetime prevalence of carcinogenic occupational circumstances: the example of painters and workers of the rubber manufacturing industry in France. J Expo Sci Environ Epidemiol 2021;31(4):769-776 (doi: 10.1038/s41370-020-00272-7).

47. Pilleron S, Charvat H, Araghi M, Arnold M, Fidler-Benaoudia MM, Bardot A, Guren MG, Tervonen H, Little A, O’Connell DL, Gavin A, De P, Aagaard Thomsen L, Moller B, Jackson C, Bucher O, Walsh PM, Vernon S, Bray F, Soerjomataram I. Age disparities in stage-specific colon cancer survival across seven countries: an ICBP SURVMARK-2 population-based study. Int J Cancer 2021;148(7):1575-1585 (doi: 10.1002/ijc.33326).

46. Nozue M, Shimazu T, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented soy products intake and risk of cardiovascular disease and total cancer incidence: the Japan Public Health Center-based Prospective Study. Eur J Clin Nutr 2021;75(6):954-968 (doi: 10.1038/s41430-020-00732-1).

45. Li M, Sun Y, Yang J, de Martel C, Charvat H, Clifford GM, Vaccarella S, Wang L. Time trends and other sources of variation in Helicobacter pylori infection in mainland China: a systematic review and meta-analysis. Helicobacter 2020;25(5):e12729 (doi: 10.1111/hel.12729).

44. Miranda-Filho A, Bray F, Charvat H, Rajaraman S, Soerjomataram I. The world cancer patient population (WCPP): an updated standard for international comparisons of population-based survival. Cancer Epidemiol 2020;69:101802 (doi: 10.1016/j.canep.2020.101802).

43. Charvat H, Shimazu T, Inoue M, Iwasaki M, Sawada N, Yamaji T, Tsugane S; JPHC Study Group. Estimation of the performance of a risk prediction model for gastric cancer occurrence in Japan: evidence from a small external population. Cancer Epidemiol 2020;67:101766 (doi: 10.1016/j.canep.2020.101766).

42. Van Alsten SC, Rabkin CS, Sawada N, Shimazu T, Charvat H, Yamaji T, Inoue M, Kemp TJ, Pinto LA, Camargo MC, Tsugane S, Song M. Metabolic syndrome, physical activity, and inflammation: a cross-sectional analysis of 110 circulating biomarkers in Japanese adults. Cancer Epidemiol Biomarkers Prev 2020;29(8):1639-1646 (doi: 10.1158/1055-9965.EPI-19-1513).

41. Budhathoki S, Iwasaki M, Yamaji T, Hamada GS, Miyajima NT, Zampieri JC, Sharma S, Pakseresht M, Kolahdooz F, Ishihara J, Takachi R, Charvat H, Le Marchand L, Tsugane S. Doneness preferences, meat and meat-derived heterocyclic amines intake, and N-acetyltransferase 2 polymorphisms: association with colorectal adenoma in Japanese Brazilians. Eur J Cancer Prev 2020;29(1):7-14 (doi: 10.1097/CEJ.0000000000000506).

40. Noh H, Charvat H, Freisling H, Olafsdottir GH, Olafsdottir EJ, Tryggvadottir L, Arnold M, Soerjomataram I. Cumulative exposure to premenopausal obesity and risk of postmenopausal cancer: a population-based study in Icelandic women. Int J Cancer 2020;147(3):793-802 (doi: 10.1002/ijc.32805).

39. Aversa J, Song M, Shimazu T, Inoue M, Charvat H, Yamaji T, Sawada N, Pfeiffer RM, Karimi P, Dawsey SM, Rabkin CS, Tsugane S, Camargo MC. Prediagnostic circulating inflammation biomarkers and esophageal squamous cell carcinoma: a case-cohort study in Japan. Int J Cancer 2020;147(3):686-691 (doi: 10.1002/ijc.32763).

38. Oze I, Charvat H, Matsuo K, Ito H, Tamakoshi A, Nagata C, Wada K, Sugawara Y, Sawada N, Yamaji T, Naito M, Tanaka K, Shimazu T, Mizoue T, Tsugane S, Inoue M. Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? Cancer Med 2019;8(14):6414-6425 (doi: 10.1002/cam4.2514).

37. Hugues A, Di Marco J, Ribault S, Ardaillon H, Janiaud P, Xue Y, Zhu J, et al. Limited evidence of physical therapy on balance after stroke: a systematic review and meta-analysis. PLos One 2019;14(8):e0221700 (doi: 10.1371/journal.pone.0221700).

36. Budhathoki S, Sawada N, Iwasaki M, Yamaji T, Goto A, Kotemori A, Ishihara J, Takachi R, Charvat H, Mizoue T, Iso H, Tsugane S; Japan Public Health Center-based Prospective Study Group. Association of animal and plant protein intake with all-cause and cause-specific mortality. JAMA Intern Med 2019;179(11):1509-1518 (doi: 10.1001/jamainternmed.2019. 2806).

35. Kipourou DK, Charvat H, Rachet B, Belot A. Estimation of the adjusted cause-specific cumulative probability using flexible regression models for the cause-specific hazards. Stat Med 2019;38(20):3896-3910 (doi: 10.1002/sim.8209).

34. Arnold M, Charvat H, Freisling H, Noh H, Adami HO, Soerjomataram I, Weiderpass E. Adulthood overweight and survival from breast and colorectal cancer in Swedish women. Cancer Epidemiol Biomarkers Prev 2019;28(9):1518-1524 (doi: 10.1158/1055-9965.EPI-19-0075).

33. Remontet L, Uhry Z, Bossard N, Iwaz J, Belot A, Danieli C, Charvat H, Roche L; CENSUR Working Survival Group. Flexible and structured survival model for a simultaneous estimation of non-linear and non-proportional effects and complex interactions between continuous variables: performance of this multidimensional penalized spline approach in net survival trend analysis. Stat Methods Med Res 2019;28(8):2368-2384 (doi: 10.1177/0962280218779408).

32. Camargo MC, Song M, Shimazu T, Charvat H, Yamaji T, Sawada N, Kemp TJ, Pfeiffer RM, Hildesheim A, Pinto LA, Tsugane S, Rabkin CS. Circulating inflammation markers and risk of gastric and esophageal cancers: a case-cohort study within the Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev 2019;28(4):829-832 (doi: 10.1158/1055-9965.EPI-18-1157).

31. Ikeda A, Charvat H, Shigemura J, Kales SN, Tanigawa T. Longitudinal trends in disaster-related insomnia among Fukushima nuclear plant workers: the Fukushima Nuclear Energy Workers’ Support Project Study. Sleep 2019;42(5) (doi: 10.1093/sleep/zsz043).

30. Pilleron S, Soerjomataram I, Charvat H, Chokunoga E, Somdyala NIM, Wabinga H, Korir A, Bray F, Jemal A, Maxwell Parkin D. Cancer incidence in older adults in selected regions of sub-Saharan Africa, 2008-2012. Int J Cancer 2019;144(8):1824-1833 (doi: 10.1002/ijc.31880).

29. Hidaka A, Budhathoki S, Yamaji T, Sawada N, Tanaka-Mizuno S, Kuchiba A, Charvat H, Goto A, Shimazu T, Inoue M, Noda M, Tsugane S, Iwasaki M; JPHC Study Group. Plasma C-peptide and glycated albumin and subsequent risk of cancer: from a large prospective case-cohort study in Japan. Int J Cancer 2019;144(4):718-729 (doi: 10.1002/ijc.31847).

28. Mori N, Shimazu T, Charvat H, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Goto A, Takachi R, Ishihara J, Noda M, Iso H, Tsugane S; JPHC Study Group. Cruciferous vegetable intake and mortality in middle-aged adults: a prospective cohort study. Clin Nutr 2019;38(2):631-643 (doi: 10.1016/j.clnu.2018.04.012).

27. Song M, Sasazuki S, Camargo MC, Shimazu T, Charvat H, Yamaji T, Sawada N, Kemp TJ, Pfeiffer RM, Hildesheim A, Pinto LA, Rabkin CS, Tsugane S. Circulating inflammatory markers and colorectal cancer risk: a prospective case-cohort study in Japan. Int J Cancer 2018;143(11):2767-2776 (doi: 10.1002/ijc.31821).

26. Belot A, Remontet L, Rachet B, Dejardin O, Charvat H, Bara S, Guizard AV, Roche L, Launoy G, Bossard N. Describing the association between socioeconomic inequalities and cancer survival: methodological guidelines and illustration with population-based data. Clinical Epidemiol 2018;10:561-573 (doi: 10.2147/CLEP.S150848).

25. Budhathoki S, Hidaka A, Yamaji T, Sawada N, Tanaka-Mizuno S, Kuchiba A, Charvat H, Goto A, Kojima S, Sudo N, Shimazu T, Sasazuki S, Inoue M, Tsugane S, Iwasaki M; Japan Public Health Center-based Prospective Study Group. Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort. BMJ 2018;360:k671 (doi: 10.1136/bmj.k671).

24. Yamashita S, Kishino T, Takahashi T, Shimazu T, Charvat H, Kakugawa Y, Nakajima T, Lee YC, Iida N, Maeda M, Hattori N, Takeshima H, Nagano R, Oda I, Tsugane S, Wu MS, Ushijima T. Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues. Proc Natl Acad Sci USA 2018;115(6):1328-1333 (doi: 10.1073/pnas.1717340115).

23. Charvat H, Sasazuki S, Shimazu T, Budhathoki S, Inoue M, Iwasaki M, Sawada N, Yamaji T, Tsugane S; JPHC Study Group. Development of a risk prediction model for lung cancer: the Japan Public Health Center-based Prospective Study. Cancer Sci 2018;109(3):854-862 (doi: 10.1111/cas.13509).

22. Saito E, Inoue M, Sawada N, Charvat H, Shimazu T, Yamaji T, Iwasaki M, Sasazuki S, Mizoue T, Iso H, Tsugane S. Impact of alcohol intake and drinking patterns on mortality from all causes and major causes of death in a Japanese population. J Epidemiol 2018;28(3):140-148 (doi: 10.2188/jea.JE20160200).

21. Taniyama Y, Katanoda K, Charvat H, Hori M, Ohno Y, Sasazuki S, Tsugane S. Estimation of lifetime cumulative incidence and mortality risk of gastric cancer. Jpn J Clin Oncol 2017;47(11):1097-1102 (doi: 10.1093/jjco/hyx128).

20. Nozue M, Shimazu T, Sasazuki S, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented soy product intake is inversely associated with the development of high blood pressure: the Japan Public Health Center-based Prospective Study. J Nutr 2017;147(9):1749-1756 (doi: 10.3945/jn.117.250282).

19. Svensson T, Inoue M, Sawada N, Charvat H, Mimura M, Tsugane S; JPHC Study Group. High serum total cholesterol is associated with suicide mortality in Japanese women. Acta Psychiatr Scand 2017;136(3):259-268 (doi: 10.1111/acps.12758).

18. Danieli C, Bossard N, Roche L, Belot A, Uhry Z, Charvat H, Remontet L. Performance of two formal tests based on martingales residuals to check the proportional hazard assumption and the functional form of the prognostic factors in flexible parametric excess hazard models. Biostatistics 2017;18(3):505-520 (doi: 10.1093/biostatistics/kxw056).

17. Ikeda A, Tanigawa T, Charvat H, Wada H, Shigemura J, Kawachi I. Longitudinal effects of disaster-related experiences on mental health among Fukushima nuclear plant workers: the Fukushima NEWS Project Study. Psychological Medicine 2017:47(11):1936-1946 (doi: 10.1017/S0033291717000320).

16. Charvat H, Remontet L, Bossard N, Roche L, Dejardin O, Rachet B, Launoy G, Belot A; CENSUR Survival Working Group. A multilevel excess hazard model to estimate net survival on hierarchical data allowing for non-linear and non-proportional effects of covariates. Stat Med 2016;35(18):3066-3084 (doi: 10.1002/sim.6881).

15. Goto A, Noda M, Inoue M, Goto M, Charvat H. Increasing number of people with diabetes in Japan: is this trend real? Intern Med 2016;55(14):1827-1830 (doi: 10.2169/internalmedicine.55.6475).

14. Hidaka A, Sasazuki S, Matsuo K, Ito H, Charvat H, Sawada N, Shimazu T, Yamaji T, Iwasaki M, Inoue M, Tsugane S; JPHC Study Group. CYP1A1, GSTM1 and GSTT1 genetic polymorphisms and gastric cancer risk among Japanese: a nested case-control study within a large-scale population-based prospective study. Int J Cancer 2016;139(4):759-768 (doi: 10.1002/ijc.30130).

13. Saito E, Charvat H, Goto A, Matsuda T, Noda M, Sasazuki S, Inoue M. Burden of cancer associated with type 2 diabetes mellitus in Japan, 2010-2030. Cancer Sci 2016;107(4):521-527 (doi: 10.1111/cas.12902).

12. Svensson T, Inoue M, Sawada N, Yamagishi K, Charvat H, Saito I, Kokubo Y, Iso H, Kawamura N, Shibuya K, Mimura M, Tsugane S; JPHC Study Group. Coping strategies and risk of cardiovascular disease incidence and mortality: the Japan Public Health Center-based prospective study. Eur Heart J 2016;37(11):890-899 (doi: 10.1093/eurheartj/ehv724).

11. Svensson T, Inoue M, Sawada N, Charvat H, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kawamura N, Shibuya K, Mimura M, Tsugane S; JPHC Study Group. Coping strategies and cancer incidence and mortality: the Japan Public Health Center-based prospective study. Cancer Epidemiol 2016;40:126-133 (doi: 10.1016/j.canep.2015.12.003).

10. Charvat H, Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, Tsugane S; JPHC Study Group. Prediction of the 10-year probability of gastric cancer occurrence in the Japanese population: the JPHC study cohort II. Int J Cancer 2016;138(2):320-331 (doi: 10.1002/ijc.29705).

9. Shimazu T, Asada K, Charvat H, Kusano C, Otake Y, Kakugawa Y, Watanabe H, Gotoda T, Ushijima T, Tsugane S. Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study. Carcinogenesis 2015;36(11):1291-1298 (doi: 10.1093/carcin/bgv125).

8. Charvat H, Goto A, Goto M, Inoue M, Heianza Y, Arase Y, Sone H, Nakagami T, Song X, Qiao Q, Tuomilehto J, Tsugane S, Noda M, Inoue M. Impact of population aging on trends in diabetes prevalence: a meta-regression analysis of 160,000 Japanese adults. J Diabetes Investig 2015;6(5):533-542 (doi: 10.1111/jdi.12333).

7. Kawabata-Shoda E, Charvat H, Ikeda A, Inoue M, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Kimura H, Tsugane S, Masuda S. Trends in cancer prognosis in a population-based cohort survey: can recent advances in cancer therapy affect the prognosis? Cancer Epidemiol 2015;39(1):97-103 (doi: 10.1016/j.canep.2014.11.008).

6. Svensson T, Inoue M, Charvat H, Sawada N, Iwasaki M, Sasazuki S, Shimazu T, Yamaji T, Ikeda A, Kawamura N, Mimura M, Tsugane S, for the JPHC Study Group. Coping behaviors and suicide in the middle-aged and older general Japanese population: the Japan Public Health Center-based Prospective Study. Ann Epidemiol 2014;24(3):199-205 (doi: 10.1016/j.annepidem.2013.12.006).

5. Charvat H, Bossard N, Daubisse L, Binder F, Belot A, Remontet L. Probabilities of dying from cancer and other causes in French cancer patients based on an unbiased estimator of net survival: a study of five common cancers. Cancer Epidemiol 2013;37(6):857-863 (doi: 10.1016/j.canep.2013.08.006).

4. Charvat H, Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, Yamaji T, Tsugane S, for the JPHC Study Group. Impact of five modifiable lifestyle habits on the probability of cancer occurrence in the Japanese population: results from a large cohort study. Prev Med 2013;57(5):685-689 (doi: 10.1016/j.ypmed.2013.08.030).

3. Sasazuki S, Charvat H, Hara A, Wakai K, Nagata C, Nakamura K, Tsuji I, Sugawara Y, Tamakoshi A, Matsuo K, Oze I, Mizoue T, Tanaka K, Inoue M, Tsugane S; for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. Diabetes mellitus and cancer risk: pooled analysis of eight cohort studies in Japan. Cancer Sci 2013;104(11):1499-1507 (doi: 10.1111/cas.12241).

2. Charvat H, Belot A, Gueyffier F, Roy P. Expected impact of a public health intervention in the presence of synergistic risk factors. J Clin Epidemiol 2013;66(4):445-452 (doi: 10.1016/j.jclinepi.2012.11.004).

1. Charvat H, Ayzac L, Girard R, Gardes S, Ecochard R. Detecting related cases of bloodstream infections using time interval distribution modelling. J Hosp Inf 2010;74(3):250-257 (doi: 10.1016/j.jhin.2009.08.012).

「コンピュータソフト」

mexhaz (R package)
[https://cran.r-project.org/web/packages/mexhaz/index.html]

研究者

教育活動

researchmap(JST)

【学校法人順天堂】研究者情報データベース

研究業績詳細

CHARVAT Hadrien（シャルヴァ アドリアン）

CHARVAT Hadrien（シャルヴァアドリアン）