学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

小池正人（コイケマサト）

研究テーマ	各種オルガネラの異常と神経変性疾患
研究業績（論文）	欧文原著 155. Murakami, Y., Umeshita, S., Imanishi, K., Yoshioka, Y., Ninomiya, A., Sunabori, T., Likhite S., Koike, M., Mayer KC., Kinoshita, T. AAV-based gene therapy ameliorated central nervous system specific GPI defect in mouse models. Mol. Ther. Methods Clin. Dev. 32(1):101176, 2023. 154. Uemura, N., Marotta, N., Ara, Y., Meymand, E., Zhang, B., Kameda, H., Koike, M., Luk, K., Trojanowski, J., Lee, V. alpha-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate pathological features of Lewy body diseases in mice. Nat. Commun. 14(1):6892, 2023. 153. Yokota, M. , Yoshino, Y. , Hosoi, M., Hashimoto, R., Kakuta, S., Shiga, T., Ishikawa K., Okano, H., Hattori, N., Akamatsu W., Koike, M. Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutated patient tyrosine hydroxylase reporter iPSC lines. Front. Cell Dev. Biol. 11:1171440, 2023. (These authors contributed equally to this work) 152. Kanai, A., Nishida, Y., Iwamoto, T., Yokota, M., Aoyama, S., Ueki, K., Ito, M., Uzawa, H., Iida, H., Koike, M., Watada, H. Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter. Biochem. Biophys. Res. Commun. 676:132-140, 2023. 151. Silvia, L., Kato, Y., Wu YM., Yokota, M., Koike, M., Yui, S., Tsuchiya, K., Shiraki, N., Kume, S. The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells. Stem Cells 41(8):775-91, 2023. 150. Kurusu, R., Fujimoto, Y., Morishita, H. , Noshiro, D., Takada, S., Yamano, K., Tanaka, H., Arai, R., Kageyama, S., Funakoshi, T., Komatsu-Hirota, S., Taka, H., Kazuno, S., Miura, Y., Koike, M., Wakai, T., Waguri, S., Noda, N., Komatsu, M. Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Dev. Cell 58(13):1189-1205, 2023. (These authors contributed equally to this work) 149. Okamoto, K., Kamikubo, Y., Yamauchi, K., Okamoto, S., Takahashi, M., Ishida, Y., Koike, M., Ikegaya, Y., Sakurai, T., Hioki, H. Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle. Sci. Rep. 13(1):323, 2023. 148. Takahashi, M., Kobayashi, T., Mizuma, H., Yamauchi, K., Okamoto S., Okamoto, K., Ishida, Y., Koike, M., Watanabe M., Isa, T., Hioki, H. Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum. Neurosci. Res. 190:92-106, 2023. 147. Sou, YS., Yamaguchi, J., Kameda, H., Masuda, K., Maeda, Y., Uchiyama, Y., Koike, M. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS letters 596(22):2873-888, 2022. 146. Yamauchi, K., Okamoto, S., Ishida, Y., Konno, K., Hoshino, K., Furuta, T., Takahashi, M., Koike, M., Isa, K., Watanabe, M., Isa, T., Hioki, H. Fluorochromized tyramide-glucose oxidase as a multiplex fluorescent tyramide signal amplification system for histochemical analysis. Sci. Rep. 12(1):14807, 2022. 145. Yamauchi, K., Furuta, T., Okamoto, S., Takahashi, M., Koike, M., Hioki, H. Protocol for multi-scale light microscopy/electron microscopy neuronal imaging in a mouse brain tissue. STAR protocols i3(3):101508. 144. Yamauchi, K., Okamoto, S., Takahashi, M., Koike, M., Furuta, T., Hioki, H. A tissue clearing method for neuronal imaging from mesoscopic to microscopic scales. JoVE (183), 2022. 143. De Mazière, A., van der Beek, J., van Dijk, S., de Heus, C., Reggioli, F., Koike, M., Klumperman, J. An optimized protocol for immuno-electron microscopy of endogenous LC3. Autophagy 18(12):3004-22, 2022. 142. Furuta, T., Yamauchi, K., Okamoto, S., Takahashi, M., Kakuta, S., Ishida, Y., Takenaka, A., Yoshida, A., Uchiyama, Y., Koike, M., Isa, K., Isa, T., Hioki, H. Multi-scale LM/EM neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF. iScience 25(1):103601, 2021. (These authors contributed equally to this work) 141. Omar, FM., Ichimura, Y., Kageyama, S., Komatsu-Hirota, S., El-Gowily AH., Sou, YS., Koike, M., Noda, NN., Komatsu, M. Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. J. Biol. Chem. 297(6):101405, 2021. 140. Kitamura, E., Koike, M., Hirayama, T., Sunabori, T., Kameda, H., Hioki, H., Takeda, S., Itakura, A. Susceptibility of subregions of prefrontal cortex and corpus callosum to damage by high-dose oxytocin-induced labor in male neonatal mice. PLoS ONE 16(8):e0256693, 2021. 139. Ikeda, Y., Wada, A., Hasegawa, T., Yokota, M., Koike, M., Ikeda, S. Melanocyte progenitor cells reside in human subcutaneous adipose tissue. PLoS ONE 16(8):e0256622, 2021. 138. Murayama, K., Yoneda, K., Sugita, S., Yamamoto, Y., Koike, M., Peters, C., Uchiyama, Y., Nishida, K. CTLA-2 alpha is a potent inhibitor of angiogenesis in murine ocular tissue. Antioxidants 10(3):456, 2021. 137. Yokota, M., Kakuta, S., Shiga, T., Ishikawa, K., Okano, H., Hattori, N., Akamatsu W., Koike, M. Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Mol. Brain 14(1):58, 2021. 136. Yuizumi, N., Harada, Y, Kuniya, T., Sunabori, T., Koike, M., Wakabayashi, M., Ishihara, Y., Suzuki, Y., Kawaguchi D., Gotoh, Y. Maintenance of neural stem-progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon. Stem Cells 39(7):929-44, 2021. 135. Watanabe, K., Morishita, K., Zhou, X., Shiizaki, S., Uchiyama, Y., Koike, M., Naguro, I., Ichijo, H. Cells recognize osmotic stress through liquid–liquid phase separation lubricated with　poly(ADP-ribose). Nat. Commun. 12(1):1353, 2021. 134. Okamoto, S., Yamauchi, K., Sohn, J., Takahashi, M., Ishida, Y., Furuta, T., Koike, M., Fujiyama, F., Hioki, H. Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system. STAR protocols 2(1):100230, 2020. 133. Choong, C.J., Okuno, T., Ikenaka, K., Baba, K., Hayakawa, H., Koike, M., Yokota, M., Doi, J., Kakuda, K., Takeuchi, T., Kuma, A., Nakamura, S., Nagai, Y., Nagano, S., Yoshimori, T., Mochizuki, H. Alternative mitochondrial quality control mediated by extracellular release. Autophagy 17(10):2962-74, 2021. 132. Parajuli, L.K., Urakubo H., Nakazato-Takahashi A., Ogelman, R., Iwasaki, H., Kwon, BH., Koike, M., Ishii, S., Oh, WC., Fukazawa, Y., Okabe, S. Geometry and the organizational principle of spine synapses along a dendrite. eNeuro 7(6), 2020. 131. Parajuli, L.K., Wako, K., Maruo, S,. Kakuta, S., Taguchi, T., Ikuno, M., Yamakado, H., Takahashi, R., Koike, M. Developmental changes in dendritic spine morphology in the striatum and their alteration in an A53T α-synuclein BAC transgenic mouse model of Parkinson's disease. eNeuro 7(4), 2020. 130. Okamoto, S., Sohn, J., Tanaka, T., Takahashi, M., Ishida, Y., Yamauchi, K., Koike, M., Fujiyama, F., Hioki, H. Overlapping projections of neighboring direct and indirect pathway neurons to the external segment of the globus pallidus. iScience 23(9):101409, 2020. 129. Sakano, D., Inoue, A., Enomoto, T., Imasaka, M., Okada, S., Yokota, M., Koike, M., Araki, K., Kume, S. Insulin2 Q104del (Kuma) mutant mice develop diabetes with dominant inheritance. Sci. Rep. 10(1):12187, 2020. 128. Parajuli, LK., Wako, K., Maruo, S., Kakuta, S., Koike, M. Unique synaptic topography of crest-type synapses in the interpeduncular nucleus. Biochem. Biophys. Res. Commun. 530(1):130-5, 2020. 127. Sánchez-Martín, P., Sou, YS., Kageyama, S., Koike, M., Komatsu, M. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO Reports 21(3):e48902, 2020. 126. Hayakawa, H., Ikenaka, K., Aguirre, C., Nakatani, R., Choong, CJ., Tsuda, H., Nagano, S., Koike, M., Ikeuchi, T., Hasegawa, M., Papa, SM., Nagai, Y., Mochizuki, H., Baba, K. Structurally distinct -synuclein fibrils induce robust Parkinsonian pathology. Mov. Dis. 35(2):256-67, 2020. 125. Masubuchi, N., Araki, M., Yang, Y., Hayashi, E., Imai, M., Edahiro, Y., Hironaka, Y., Mizukami, Y., Kihara, Y., Takei, H., Nudejima, M., Koike, M., Ito, F., Ohsaka, A., Komatsu, N. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface. Leukemia 34(2):499-509, 2020. 124. Taguchi, T., Ikuno, M., Hondo, M., Parajuli, LK., Taguchi, K, Ueda, J., Sawamura, M., Okuda, S., Hara, J., Uemura, N., Hatanaka, Y., Ayaki, T., Matsuzawa, S., El-Agnaf, MA., Koike, M., Yanagisawa, M., Uemura, M., Yamakado, H., Takahashi, R. alpha-synuclein BAC transgenic mice exhibited RBD-like behavior and hyposmia: A prodromal Parkinson’s disease model. Brain 143(1):249-65, 2020. 123. Hirayama, T., Hiraoka, Y., Kitamura, E., Miyazaki, S., Horie, K., Fukuda, T., Hidema, S., Koike, M., Itakura, A., Takeda, S. Oxytocin induced labor causes region and sex-specific transient oligodendrocyte cell death in neonatal mouse brain. J. Obstet. Gynaecol. Res. 141(46):66-78, 2020. 122. Takahashi, SS., Sou, YS., Saito, T., Kuma, A., Yabe, T., Sugiura, Y., Lee, HC., Suematsu, M., Yokomizo, T., Koike, M., Terai, S., Mizushima, N., Waguri, S., Komatsu, M. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life Sci. Alliance 3(1): e201900513, 2019. (These authors contributed equally to this work) 121. Hwang, J., Koike, M., Hioki, H. Reduction of freezing behavior by acupuncture stimulation at HT7 in contextual fear-conditioned mice. Juntendo Medical Journal 65(6):554-60, 2019. 120. Himuro, M., Miyatsuka, T., Suzuki, L., Miura, M., Katahira, T., Goto, H., Nishida, Y., Sasaki, S., Koike, M., Shiota, C., Gittes, GK., Fujitani, Y., Watada, H. Cellular autophagy in  cells plays a role in the maintenance of islet architecture. J. Endocr. Soc. 3(11):1979-92, 2019. 119. Shigeta, Y., Fujiwara, N., Koike, M., Yamataka, A., Doi, T. Bone mineral density is increased in the cadmium-induced omphalocele chick model by using three-dimensional micro-computed tomography. Pediatr. Surg. Int. 35(8): 911-14, 2019. 118. Sou, YS., Kakuta, S., Kamikubo, Y., Niisato, K., Sakurai, T., Parajuli, LK., Tanida, I., Saito, H., Suzuki, N., Sakimura, K., Maeda, Y., Kinoshita, T., Uchiyama, Y., Koike, M. Cerebellar neurodegeneration and neuronal circuit remodeling in Golgi pH regulator deficient mice. eNeuro 6(3), 2019. 117. Shindo, R., Ohmuraya, M., Komazawa-Sakon, S., Miyake, S., Deguchi, Y., Yamazaki, S., Nishina, T., Yoshimoto, T., Kakuta, S., Koike, M., Uchiyama, Y., Konishi, H., Kiyama, H., Mikami, T., Moriwaki, K., Araki, K., Nakano, H. Necroptosis of intestinal epithelial cells induces type 3 innate lymphoid cell-dependent lethal ileitis. iScience 15:536-551, 2019. 116. Tanaka, H., Okazaki, T., Okajima, M., Yokota, M., Koike, M., Okada, Y., Fujiki, Y., Gotoh, Y. Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis. J. Cell Sci. 132(11), 2019. 115. Sato, T., Yamashina, S., Izumi, K., Ueno, T., Koike, M., Ikejima, K., Peters, C., Watanabe, S. Cathepsin L-deficiency enhances liver regeneration after partial hepatectomy. Life Sci. 221:293-300, 2019. 114. Ikuno, M., Yamakado, H., Akiyama, H., Parajuli, LK., Taguchi, K., Hara, J., Uemura, N., Hatanaka, Y., Higaki, K., Ohno, K., Tanaka, M., Koike, M., Hirabayashi, Y., Takahashi, R. GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease. Hum. Mol. Genet. 28(11):1894-1904, 2019. 113. Piao, X., Miura, R., Miyake, S., Komazawa-Sakon, S., Koike, M., Shido, R., Takeda, J., Hasegawa, A., Abe, R., Nishiyama, C., Mikami, T., Yagita, H., Uchiyama, Y., Nakano, H. Blockade of TNFR1-dependent and -independent cell death is crucial for normal epidermal differentiation. J. Allergy Clin. Immunol. 143(1):213-28, 2019. 112. Komine, O., Yamashita, H., Fujimori-Tonou, N., Koike, M., Jin, S., Moriwaki, Y., Endo, F., Watanabe, S., Uematsu, S., Akira, S., Uchiyama, Y., Takahashi, R., Misawa, H., Yamanaka, K. Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death Differ. 25(12):2130-2146, 2018. 111. .Eguchi, T., Kuwabara, T., Sakurai, M., Komori, T., Fujimoto, T., Ito, G., Yoshimura, S., Harada, A., Fukuda, M., Koike, M., Iwatsubo, T. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc. Natl. Acad. Sci. U S A 115(39):E9115-E9124, 2018. 110. Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Matsuyama, A., Goto, H., Nishida, Y., Miyatsuka, T., Fujitani, Y., Koike, M., Mitsumata, M., Watada, H. Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. Autophagy 14(11):1991-2006, 2018. 109. Shimada, Y., Shimura, H., Tanaka, R., Yamashiro, K., Koike, M., Uchiyama, Y., Urabe, T., Hattori, N. Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator. PLoS One 13(5):e0198039, 2018. 108. Ogawa, M., Matsuda, R., Takada, N., Tomokiyo, M., Yamamoto, S., Shizukuishi, S., Yamaji, T., Yoshikawa, Y., Yoshida, M., Tanida, I., Koike, M., Murai, M., Morita, H., Takeyama, H., Ryo, A., Guan, JL., Yamamoto, M., Inoue, J., Yanagawa, T., Fukuda, M., Kawabe, H., Ohnishi, M. Mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination. Cell Microbiol. 20(8):e12846, 2018. 107. Tanida-Miyake, E., Koike, M., Uchiyama, Y., Tanida, I. Optimization of mNeonGreen for Homo sapiens increases its fluorescent intensity in mammalian cells. Plos One 13(1):e0191108, 2018. 106. Takakura, K., Ito, S., Sonoda, J., Tabata, K., Shiozaki, M., Nagai, K., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T. Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions. Heliyon 3(11):e00462, 2017. 105. Tsuiji, H., Inoue, I., Takeuchi, M., Furuya, A., Yamakage, Y., Watanabe, S., Koike, M., Hattori, M., Yamanaka, K. TDP-43 accelerates age-dependent degeneration of interneurons. Sci. Rep. 7(1):14972, 2017. 104. Iwamoto, S., Koga, T., Ohba, M., Okuno, T., Koike, M., Murakami, A., Yokomizo, T. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing 12-hydroxyheptadecatrienoic acid, an endogenous ligand for leukotriene B4 receptor 2, BLT2. Sci. Rep. 7(1):13267, 2017. 103. Inoshita, T., Arano, T., Hosaka, Y., Meng, H., Umezaki, Y., Kosugi, S., Morimoto, T., Koike, M., Chang, HY., Imai, Y., Hattori, N. Vps35 in cooperation with LRRK2 regulates neuronal synaptic functions through the endosomal pathway in Drosophila. Hum. Mol. Genet. 26(15):2933-48, 2017. 102. Koike, M., Shibata, M., Sunabori, T., Yamaguchi, J., Sakimura, K., Komatsu, M., Tanaka, K., Uchiyama, Y. Purkinje cells are more vulnerable to the specific depletion of cathepsin D than to that of Atg7. Am. J. Pathol. 187(7):1586-600, 2017. 101. Ishimoto, T., Ninomiya, K., Inoue, R., Koike, M., Uchiyama, Y., Mori, H. Mice lacking BCAS1, a novel myelin-associated protein, display schizophrenia-like abnormal behaviors, and up-regulation of inflammatory genes in the brain. Glia 65(5):727-39, 2017. (These authors contributed equally to this work) 100. Koike, M., Kawahara, A., Shibata, M., Uchiyama, Y. Induction of autophagy in the hippocampus after hypoxic-ischemic injury to neonatal rats. Arch. Histol. Cytol. 77(1):13-23, 2017. 99. Ichimura, K., Kakuta, S., Kawasaki, Y., Miyaki, T., Nonami, T., Miyazaki, N., Enomoto, S., Arai, S., Koike, M., Murata, K., Sakai, T. Morphological process of podocyte development revealed by block-face scanning electron microscopy. J. Cell Sci. 130(1):132-142, 2017. 98. Tsuboyama, K., Koyama-Honda, I., Sakamaki, Y., Koike, M., Morishita, H., Mizushima, N. The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. Science 354(6315):1036-41, 2016. (These authors contributed equally to this work) 97. Yamanaka, T., Tosaki, A., Miyazaki, H., Kurosawa, M., Koike, M., Uchiyama, Y., Maity, SN., Misawa, H., Takahashi, R., Shimogori, T., Hattori, N., Nukina, N. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Sci. Rep. 6:34575, 2016. 96. Sato, S., Koike, M., Funayama, M., Ezaki, J., Fukuda, T., Ueno, T., Uchiyama, Y., Hattori, N. Lysosomal storage of subunit c of mitochondrial ATP synthase in brain-specific ATP13a2-deficient mice. Am. J. Pathol. 186(12):3074-82, 2016. 95. Hadano, S., Mitsui, S., Pan, L., Otomo, A., Kubo, M., Sato, K., Ono, S., Onodera, W., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, HF., Yoshii, F. Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: Cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hum. Mol. Genet. 25(15):3321-40, 2016. 94. Sunabori, T., Koike, M., Asari, A., Oonuki, Y., Uchiyama, Y. Suppression of ischemia-induced hippocampal pyramidal neuron death by hyaluronan tetrasaccharide through inhibition of Toll-like receptor 2 signaling pathway. Am. J. Pathol. 186(8):2143-51, 2016. 93. Morales, J., Hashimoto, M.,Williams, T., Hirawake-Mogi, H., Makiuchi, T., Tsubouchi, A., Kaga, N., Taka, H., Fujimura, T., Mita, T., Koike, M., Bringaud, F., Concepción, J., Hashimoto, T., Embley, M., Nara, T. Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids. Proceedings of the Royal Society B 283(1830), 2016. 92. Shibata, M., Koike, M., Kusumi, S., Sato, N., Uchiyama, Y. A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney. Arch Histol Cytol. 76(1):1-8, 2016. 91. Sekine S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H. PGAM5 deficiency confers resistance against metabolic stress in mice. EBioMedicine 5:82-92, 2016. (These authors contributed equally to this work) 90. Yamada, D., Saiki, S., Furuya, N., Ishikawa, K., Imamichi, Y., Kambe, T., Fujimura, T., Ueno, T., Koike, M., Hattori, N. Lysosomal neutralization triggered by Zn2+ accumulation through ZnT2 inhibits autophagy. Biochem. Biophys. Res. Commun. 471(1):109-16, 2016. 89. Yamamoto-Nonaka K., Koike, M., Asanuma, K., Akiba-Takagi, M., Trejo, JA., Seki, T., Hidaka, T., Ichimura, K., Sakai, T., Tada, N., Ueno, T., Uchiyama, Y., Tomino, Y. Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD. J. Am. Soc. Nephrol. 27(9):2685-700, 2016. 88. Xie, C., Ginet, V., Sun, Y., Koike, M., Zhou, K., Li, T., Li, H., Li, Q., Wang, X., Uchiyama, Y., Truttmann, AC., Kroemer, G., Puyal, J., Blomgren, K., Zhu, C. Neuroprotection by selective neuronal deletion of autophagy-related gene ATG7 in neonatal brain injury. Autophagy 12(2):410-23, 2016. 87. Mori, J. , Tang, H. , Kawabata, A., Koike, M., Mori, Y. Human herpesvirus 6A U14 is important for virus maturation. J. Virol. 90(3):1677-81, 2015. (These authors contributed equally to this work) 86. Fuse, A., Furuya, N., Kakuta, S., Inose, A., Sato, M., Koike, M., Saiki, S., Hattori, N. VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process. FEBS let 589(13):1430-6, 2015. (These authors contributed equally to this work) 85. Rinchai, D., Riyapa, D., Buddhisa, S., Utispan, K., Titball, R.W., Stevens, P.M., Stevens, J.M., Ogawa, M., Tanida, I., Koike, M., Uchiyama, Y., Ato, M., Lertmemongkolchai, G. Macroautophagy is essential for killing of Burkholderia pseudomallei in human neutrophils. Autophagy 11(5):748-55, 2015. 84. Nanao, T., Koike, M., Yamaguchi, J., Sasaki, M., Uchiyama, Y. Cellular localization and tissue distribution of endogenous DFCP1 protein. Biomed. Res. 36(2):121-33, 2015. (These authors contributed equally to this work) 83. Uemura, N., Koike, M., Asai, K., Kinoshita, M., Fujiwara-Ishikawa, T., Matsui, H., Naruse, K., Sakamoto, N., Uchiyama, Y., Todo, T., Takeda S.I., Yamakado, H., Takahashi, R. Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. Plos Genet. 11(4):e1005065. 82. Ichimura, K., Miyazaki, N., Sadayama, S., Murata, K., Koike, M., Nakamura, K., Ohta, K., Sakai, T. Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy. Sci. Rep. 5:8993. 81. Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu A., Koya, I., Yoshida, R., Kudoh, J., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Nakamura, M., Okano, H. Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Rep. 4(3):360-73. 80. Asano, T., Koike, M., Sakata, S., Takeda, Y., Nakagawa, T., Hatano, T., Ohashi, S., Funayama, M., Yoshimi, K., Asanuma, M., Toyokuni, S., Mochizuki, S., Uchiyama, Y., Hattori, N., Iwai, K. Iron induces mitochondrial damage that recruits parkin. Neurosci. Lett. 588:29-35, 2015. (These authors contributed equally to this work) 79. Ueno, Y., Koike, M., Shimada, Y., Shimura, H., Uchiyama, Y., Hattori, N., Urabe, T. L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain. J. Cereb. Blood Flow Metab. 35(3):382-91, 2015. 78. Suyama, M., Koike, M., Asaoka, D., Mori, H., Oguro, M., Ueno, T., Nagahara, A., Watanabe, S. Uchiyama, Y. Increased immunoreactivity of cathepsins in the rat esophagus under chronic acid reflux esophagitis. J. Histochem. Cytochem. 62(9):645-60, 2014. (These authors contributed equally to this work) 77. Ueshima S., Nishida, T., Koike, M., Matsuda, H., Sawa, Y., Uchiyama, Y. Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal motility under endotoxemia of mice. Biomed. Res. 35(4):251-62, 2014. 76. Shigihara, N., Fukunaka, A., Hara, A., Komiya, K., Honda, A., Uchida, T., Abe, H., Toyofuku, Y., Tamaki, M., Ogihara, T., Miyatsuka, T., Hiddinga, HJ, Sakagashira. 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A case of multicentric Castleman's disease demonstrating severe eosinophilia and enhanced production of interleukin-5. Eur. J. Haematol 70(2): 115-8; 2003. 9. Sakakibara, S., Nakamura, Y., Yoshida, T., Shibata, S., Koike, M., Takano, H., Ueda, S., Uchiyama, Y., Noda, T., Okano, H. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc. Natl. Acad. Sci. U S A 99(23): 15194-9; 2002. 8. Koike, M., Shibata, M., Ohsawa, Y., Kametaka, S., Waguri, S., Kominami, E., Uchiyama, Y. The expression of tripeptidyl peptidase I in various tissues of rats and mice. Arch. Histol. Cytol. 65(3): 219-32; 2002. 7. Ogawa, Y., Sawamoto, K., Miyata, T., Miyao, S., Watanabe, M., Nakamura, M., Bregman, B.S., Koike, M., Uchiyama, Y., Toyama, Y., Okano, H. Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J. Neurosci. Res. 69(6): 925-33; 2002. 6. Shibata, M., Koike, M., Waguri, S., Zhang, G., Koga, T., Uchiyama, Y. Cathepsin D is specifically inhibited by deoxyribonucleic acids. FEBS letters. 517(1-3): 281-4; 2002. 5. Yoshikawa, M., Uchida, S., Ezaki, J., Rai, T., Hayama, A., Kobayashi, K., Kida, Y., Noda, M., Koike, M., Uchiyama, Y., Marumo, F., Kominami, E., Sasaki, S. CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells 7(6): 597-605; 2002. 4. Waguri, S., Kohmura, M., Kanamori, S., Watanabe, T., Ohsawa, Y., Koike, M., Tomiyama, Y., Wakasugi, M., Kominami, E., Uchiyama Y. Different distribution patterns of the two mannose 6-phosphate receptors in rat liver. J. Histochem. Cytochem. 49(11): 1397-405; 2001. 3. Nakanishi, H., Zhang, J., Koike, M., Nishioku, T., Okamoto, Y., Kominami, E., von Figura, K., Peters, C., Yamamoto, K., Saftig, P., Uchiyama, Y. Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J. Neurosci. 21(19): 7526-33; 2001. 2. Yayoi, Y., Ohsawa Y., Koike, M., Zhang, G., Kominami E., Uchiyama Y. Specific localization of lysosomal aminopeptidases in type II alveolar epithelial cells of the rat lung. Arch. Histol. Cytol. 64(1): 89-97; 2001. 1. Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., von Figura, K., Uchiyama, Y. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J. Neurosci. 20(18): 6898-906; 2000. (These authors contributed equally to this work) 欧文総説 6. Parajuli, L.K., Koike, M. Three-dimensional structure of dendritic spines revealed by volume electron microscopy techniques. Front. Neuroanat. in press. 5. Klionsky, D.J. et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1):1-382, 2021. 4. Klionsky, D.J. et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222, 2016. 3. Klionsky, D.J. and 1268 authors. Guidelines for the use and interpretation of assays for monitoring autophagy (2nd edition). Autophagy 8(4) 445-544; 2012. 2. Uchiyama, Y., Shibata, M., Koike, M., Yoshimura, K., Sasaki, M. Autophagy-physiology and pathophysiology. Histochem. Cell Biol. 129(4): 407-20; 2008. 1. Uchiyama, Y., Koike, M., Shibata, M. Autophagic neuron death in neonatal brain ischemia/hypoxia. Autophagy 4(4): 404-8; 2008. 欧文図書 4. Tanida, I., Koike, M. John Wiley & Sons Inc., Techniques for studying autophagy. In: Autophagy, Infection, and the Immune Response. Ed. William Jackson, 19-32; 2014. 3. Komatsu, M., Koike, M., Ichimura Y., Uchiyama, Y. Genetic mouse models for elucidation of autophagy-lysosomal systems in neurons under physiologic and pathologic conditions. In: Autophagy of the Nervous System: Cellular Self-digestion in Neurons and Neurological Disease. Eds.Zhenyu Yue and Charleen T Chu, 176-204; 2012. 2. Uchiyama, Y., Koike M., Shibata, M. Springer Japan. Autophagy and cell death. In: Molecular imaging for integrated medical therapy and drug development. Eds. Nagara Tamaki and Yuji Kuge, 176-88; 2010. 1. Uchiyama, Y., Koike M., Shibata, M., Sasaki, M. Elsevier Inc. Autophagic neuron death. In: Methods Enzymol. Vol.453 (Autophagy in Disease and Clinical Applications, Part C) Ed. Daniel J. Klionsky, 33-51; 2009. 邦文著書 4. 小池正人「各種免疫電子顕微鏡法の実践」組織細胞化学2021(日本組織細胞化学会編集) (学際企画), 145-161, 2021. 3. 小池正人「TEMを使った免疫電子顕微鏡法の実践」組織細胞化学2018 (日本組織細胞化学会編集) (学際企画), 91-107, 2018. 2. 小池正人、内山安男.「リソソーム内の分解機構」オートファジー　生命をささえる細胞の自己分解システム (水島昇・吉森保編集) (化学同人), 67-76, 2012. 1. 小池正人「マウス低酸素-脳虚血負荷後の神経細胞死の遺伝学的検討」ブレインサイエンスレビュー2011 (伊藤正男・川合述史編集)（クバプロ） 149-68, 2011. 邦文総説 11. 小池正人.「パーキンソン病とリソソーム」生体の科学 73(3): 256-60; 2022. 10. 小池正人.「徳安法の基礎と応用」顕微鏡 56(3): 145-61; 2021. 9. 小池正人.「三次元電子顕微鏡法」医学のあゆみ272(9): 934-9; 2020. 8. 小池正人.「電子顕微鏡三次元立体再構築による組織細胞の観察の有用性と今後の課題」LISA 25(1): 79-89; 2018. 7. 小池正人.「ライソゾーム分解系」生体の科学 66(5): 496-7; 2015. 6. 小池正人、内山安男.「神経性セロイドリポフスチン蓄積症における”異常なリソソーム”のオートファジーによる処理」生体の科学 63(5): 505-4; 2012. 5. 小池正人、内山安男.「リソソームプロテアーゼの多様性とその病態生理学的役割」実験医学増刊号 29(12): 1903-8; 2011. 4. 小池正人、内山安男.「脳虚血とオートファジー, ユビキチン・プロテアソーム系の役割」医学のあゆみ231(5): 347-51; 2009. 3. 小池正人、内山安男.「オートファジーの超微形態観察」臨床検査 53(12): 1535-41; 2009. 2. 小池正人、内山安男.「オートファジーと神経細胞死」医学のあゆみ 225(6): 491-4; 2008. 1. 内山安男、小池正人. 「カテプシンD遺伝子欠損は神経性セロイドリポフスチン蓄積症の原因の一つか」遺伝子医学 5(2): 278-82; 2001. 紀要 3. 小池正人：リソソーム膜蛋白 p18 欠損による髄鞘形成不全の機構．上原記念生命科学財団研究報告集 30:1-5, 2016 2. 小池正人、柴田昌宏、小松雅明、石井哲郎、田中啓二、木南英紀、内山安男、「進行性ミオクロニーてんかんの一種である神経性セロイドリポフスチン蓄積症のモデルマウスにおけるてんかん発生機序の解明」てんかん治療研究振興財団研究年報　 21:49-56; 2010. 1. 榊原伸一、中村由紀、小池正人、高野洋志、佐藤均、内山安男、野田哲生、岡野栄之、「ノックアウトマウスを用いたMusashi1(Msi1)の機能及び水頭症発症機序の解析」厚生科学研究費補助金特定疾患対策研究事業難治性水頭症調査研究班平成11年度研究報告書 2000年3月 16-25頁

研究テーマ

各種オルガネラの異常と神経変性疾患

研究業績（論文）

欧文原著
155. Murakami, Y., Umeshita, S., Imanishi, K., Yoshioka, Y., Ninomiya, A., Sunabori, T., Likhite S., Koike, M., Mayer KC., Kinoshita, T. AAV-based gene therapy ameliorated central nervous system specific GPI defect in mouse models. Mol. Ther. Methods Clin. Dev. 32(1):101176, 2023.

154. Uemura, N., Marotta, N., Ara, Y., Meymand, E., Zhang, B., Kameda, H., Koike, M., Luk, K., Trojanowski, J., Lee, V. alpha-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate pathological features of Lewy body diseases in mice. Nat. Commun. 14(1):6892, 2023.

153. Yokota, M. *, Yoshino, Y. *, Hosoi, M., Hashimoto, R., Kakuta, S., Shiga, T., Ishikawa K., Okano, H., Hattori, N., Akamatsu W., Koike, M. Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutated patient tyrosine hydroxylase reporter iPSC lines. Front. Cell Dev. Biol. 11:1171440, 2023. (*These authors contributed equally to this work)

152. Kanai, A., Nishida, Y., Iwamoto, T., Yokota, M., Aoyama, S., Ueki, K., Ito, M., Uzawa, H., Iida, H., Koike, M., Watada, H. Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter. Biochem. Biophys. Res. Commun. 676:132-140, 2023.

151. Silvia, L., Kato, Y., Wu YM., Yokota, M., Koike, M., Yui, S., Tsuchiya, K., Shiraki, N., Kume, S. The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells. Stem Cells 41(8):775-91, 2023.

150. Kurusu, R.*, Fujimoto, Y.*, Morishita, H. *, Noshiro, D., Takada, S., Yamano, K., Tanaka, H., Arai, R., Kageyama, S., Funakoshi, T., Komatsu-Hirota, S., Taka, H., Kazuno, S., Miura, Y., Koike, M., Wakai, T., Waguri, S., Noda, N., Komatsu, M. Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Dev. Cell 58(13):1189-1205, 2023. (*These authors contributed equally to this work)

149. Okamoto, K., Kamikubo, Y., Yamauchi, K., Okamoto, S., Takahashi, M., Ishida, Y., Koike, M., Ikegaya, Y., Sakurai, T., Hioki, H. Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle. Sci. Rep. 13(1):323, 2023.

148. Takahashi, M., Kobayashi, T., Mizuma, H., Yamauchi, K., Okamoto S., Okamoto, K., Ishida, Y., Koike, M., Watanabe M., Isa, T., Hioki, H. Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum. Neurosci. Res. 190:92-106, 2023.

147. Sou, YS., Yamaguchi, J., Kameda, H., Masuda, K., Maeda, Y., Uchiyama, Y., Koike, M. GPHR-mediated acidification of the Golgi lumen is essential for cholesterol biosynthesis in the brain. FEBS letters 596(22):2873-888, 2022.

146. Yamauchi, K., Okamoto, S., Ishida, Y., Konno, K., Hoshino, K., Furuta, T., Takahashi, M., Koike, M., Isa, K., Watanabe, M., Isa, T., Hioki, H. Fluorochromized tyramide-glucose oxidase as a multiplex fluorescent tyramide signal amplification system for histochemical analysis. Sci. Rep. 12(1):14807, 2022.

145. Yamauchi, K., Furuta, T., Okamoto, S., Takahashi, M., Koike, M., Hioki, H. Protocol for multi-scale light microscopy/electron microscopy neuronal imaging in a mouse brain tissue. STAR protocols i3(3):101508.

144. Yamauchi, K., Okamoto, S., Takahashi, M., Koike, M., Furuta, T., Hioki, H. A tissue clearing method for neuronal imaging from mesoscopic to microscopic scales. JoVE (183), 2022.

143. De Mazière, A., van der Beek, J., van Dijk, S., de Heus, C., Reggioli, F., Koike, M., Klumperman, J. An optimized protocol for immuno-electron microscopy of endogenous LC3. Autophagy 18(12):3004-22, 2022.

142. Furuta, T.*, Yamauchi, K.*, Okamoto, S., Takahashi, M., Kakuta, S., Ishida, Y., Takenaka, A., Yoshida, A., Uchiyama, Y., Koike, M., Isa, K., Isa, T., Hioki, H. Multi-scale LM/EM neuronal imaging from brain to synapse with a tissue clearing method, ScaleSF. iScience 25(1):103601, 2021. (*These authors contributed equally to this work)

141. Omar, FM., Ichimura, Y., Kageyama, S., Komatsu-Hirota, S., El-Gowily AH., Sou, YS., Koike, M., Noda, NN., Komatsu, M. Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity. J. Biol. Chem. 297(6):101405, 2021.

140. Kitamura, E., Koike, M., Hirayama, T., Sunabori, T., Kameda, H., Hioki, H., Takeda, S., Itakura, A. Susceptibility of subregions of prefrontal cortex and corpus callosum to damage by high-dose oxytocin-induced labor in male neonatal mice. PLoS ONE 16(8):e0256693, 2021.

139. Ikeda, Y., Wada, A., Hasegawa, T., Yokota, M., Koike, M., Ikeda, S. Melanocyte progenitor cells reside in human subcutaneous adipose tissue. PLoS ONE 16(8):e0256622, 2021.

138. Murayama, K., Yoneda, K., Sugita, S., Yamamoto, Y., Koike, M., Peters, C., Uchiyama, Y., Nishida, K. CTLA-2 alpha is a potent inhibitor of angiogenesis in murine ocular tissue. Antioxidants 10(3):456, 2021.

137. Yokota, M., Kakuta, S., Shiga, T., Ishikawa, K., Okano, H., Hattori, N., Akamatsu W., Koike, M. Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons. Mol. Brain 14(1):58, 2021.

136. Yuizumi, N., Harada, Y, Kuniya, T., Sunabori, T., Koike, M., Wakabayashi, M., Ishihara, Y., Suzuki, Y., Kawaguchi D., Gotoh, Y. Maintenance of neural stem-progenitor cells by the lysosomal biosynthesis regulators TFEB and TFE3 in the embryonic mouse telencephalon. Stem Cells 39(7):929-44, 2021.

135. Watanabe, K., Morishita, K., Zhou, X., Shiizaki, S., Uchiyama, Y., Koike, M., Naguro, I., Ichijo, H. Cells recognize osmotic stress through liquid–liquid phase separation lubricated with　poly(ADP-ribose). Nat. Commun. 12(1):1353, 2021.

134. Okamoto, S., Yamauchi, K., Sohn, J., Takahashi, M., Ishida, Y., Furuta, T., Koike, M., Fujiyama, F., Hioki, H. Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system. STAR protocols 2(1):100230, 2020.

133. Choong, C.J., Okuno, T., Ikenaka, K., Baba, K., Hayakawa, H., Koike, M., Yokota, M., Doi, J., Kakuda, K., Takeuchi, T., Kuma, A., Nakamura, S., Nagai, Y., Nagano, S., Yoshimori, T., Mochizuki, H. Alternative mitochondrial quality control mediated by extracellular release. Autophagy 17(10):2962-74, 2021.

132. Parajuli, L.K., Urakubo H., Nakazato-Takahashi A., Ogelman, R., Iwasaki, H., Kwon, BH., Koike, M., Ishii, S., Oh, WC., Fukazawa, Y., Okabe, S. Geometry and the organizational principle of spine synapses along a dendrite. eNeuro 7(6), 2020.

131. Parajuli, L.K., Wako, K., Maruo, S,. Kakuta, S., Taguchi, T., Ikuno, M., Yamakado, H., Takahashi, R., Koike, M. Developmental changes in dendritic spine morphology in the striatum and their alteration in an A53T α-synuclein BAC transgenic mouse model of Parkinson's disease. eNeuro 7(4), 2020.

130. Okamoto, S., Sohn, J., Tanaka, T., Takahashi, M., Ishida, Y., Yamauchi, K., Koike, M., Fujiyama, F., Hioki, H. Overlapping projections of neighboring direct and indirect pathway neurons to the external segment of the globus pallidus. iScience 23(9):101409, 2020.

129. Sakano, D., Inoue, A., Enomoto, T., Imasaka, M., Okada, S., Yokota, M., Koike, M., Araki, K., Kume, S. Insulin2 Q104del (Kuma) mutant mice develop diabetes with dominant inheritance. Sci. Rep. 10(1):12187, 2020.

128. Parajuli, LK., Wako, K., Maruo, S., Kakuta, S., Koike, M. Unique synaptic topography of crest-type synapses in the interpeduncular nucleus. Biochem. Biophys. Res. Commun. 530(1):130-5, 2020.

127. Sánchez-Martín, P., Sou, YS., Kageyama, S., Koike, M., Komatsu, M. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO Reports 21(3):e48902, 2020.

126. Hayakawa, H., Ikenaka, K., Aguirre, C., Nakatani, R., Choong, CJ., Tsuda, H., Nagano, S., Koike, M., Ikeuchi, T., Hasegawa, M., Papa, SM., Nagai, Y., Mochizuki, H., Baba, K. Structurally distinct -synuclein fibrils induce robust Parkinsonian pathology. Mov. Dis. 35(2):256-67, 2020.

125. Masubuchi, N., Araki, M., Yang, Y., Hayashi, E., Imai, M., Edahiro, Y., Hironaka, Y., Mizukami, Y., Kihara, Y., Takei, H., Nudejima, M., Koike, M., Ito, F., Ohsaka, A., Komatsu, N. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface. Leukemia 34(2):499-509, 2020.

124. Taguchi, T., Ikuno, M., Hondo, M., Parajuli, LK., Taguchi, K, Ueda, J., Sawamura, M., Okuda, S., Hara, J., Uemura, N., Hatanaka, Y., Ayaki, T., Matsuzawa, S., El-Agnaf, MA., Koike, M., Yanagisawa, M., Uemura, M., Yamakado, H., Takahashi, R. alpha-synuclein BAC transgenic mice exhibited RBD-like behavior and hyposmia: A prodromal Parkinson’s disease model. Brain 143(1):249-65, 2020.

123. Hirayama, T., Hiraoka, Y., Kitamura, E., Miyazaki, S., Horie, K., Fukuda, T., Hidema, S., Koike, M., Itakura, A., Takeda, S. Oxytocin induced labor causes region and sex-specific transient oligodendrocyte cell death in neonatal mouse brain. J. Obstet. Gynaecol. Res. 141(46):66-78, 2020.

122. Takahashi, SS.*, Sou, YS.*, Saito, T., Kuma, A., Yabe, T., Sugiura, Y., Lee, HC., Suematsu, M., Yokomizo, T., Koike, M., Terai, S., Mizushima, N., Waguri, S., Komatsu, M. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life Sci. Alliance 3(1): e201900513, 2019. (*These authors contributed equally to this work)

121. Hwang, J., Koike, M., Hioki, H. Reduction of freezing behavior by acupuncture stimulation at HT7 in contextual fear-conditioned mice. Juntendo Medical Journal 65(6):554-60, 2019.

120. Himuro, M., Miyatsuka, T., Suzuki, L., Miura, M., Katahira, T., Goto, H., Nishida, Y., Sasaki, S., Koike, M., Shiota, C., Gittes, GK., Fujitani, Y., Watada, H. Cellular autophagy in  cells plays a role in the maintenance of islet architecture. J. Endocr. Soc. 3(11):1979-92, 2019.

119. Shigeta, Y., Fujiwara, N., Koike, M., Yamataka, A., Doi, T. Bone mineral density is increased in the cadmium-induced omphalocele chick model by using three-dimensional micro-computed tomography. Pediatr. Surg. Int. 35(8): 911-14, 2019.

118. Sou, YS., Kakuta, S., Kamikubo, Y., Niisato, K., Sakurai, T., Parajuli, LK., Tanida, I., Saito, H., Suzuki, N., Sakimura, K., Maeda, Y., Kinoshita, T., Uchiyama, Y., Koike, M. Cerebellar neurodegeneration and neuronal circuit remodeling in Golgi pH regulator deficient mice. eNeuro 6(3), 2019.

117. Shindo, R., Ohmuraya, M., Komazawa-Sakon, S., Miyake, S., Deguchi, Y., Yamazaki, S., Nishina, T., Yoshimoto, T., Kakuta, S., Koike, M., Uchiyama, Y., Konishi, H., Kiyama, H., Mikami, T., Moriwaki, K., Araki, K., Nakano, H. Necroptosis of intestinal epithelial cells induces type 3 innate lymphoid cell-dependent lethal ileitis. iScience 15:536-551, 2019.

116. Tanaka, H., Okazaki, T., Okajima, M., Yokota, M., Koike, M., Okada, Y., Fujiki, Y., Gotoh, Y. Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis. J. Cell Sci. 132(11), 2019.

115. Sato, T., Yamashina, S., Izumi, K., Ueno, T., Koike, M., Ikejima, K., Peters, C., Watanabe, S. Cathepsin L-deficiency enhances liver regeneration after partial hepatectomy. Life Sci. 221:293-300, 2019.

114. Ikuno, M., Yamakado, H., Akiyama, H., Parajuli, LK., Taguchi, K., Hara, J., Uemura, N., Hatanaka, Y., Higaki, K., Ohno, K., Tanaka, M., Koike, M., Hirabayashi, Y., Takahashi, R. GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson's disease. Hum. Mol. Genet. 28(11):1894-1904, 2019.

113. Piao, X., Miura, R., Miyake, S., Komazawa-Sakon, S., Koike, M., Shido, R., Takeda, J., Hasegawa, A., Abe, R., Nishiyama, C., Mikami, T., Yagita, H., Uchiyama, Y., Nakano, H. Blockade of TNFR1-dependent and -independent cell death is crucial for normal epidermal differentiation. J. Allergy Clin. Immunol. 143(1):213-28, 2019.

112. Komine, O., Yamashita, H., Fujimori-Tonou, N., Koike, M., Jin, S., Moriwaki, Y., Endo, F., Watanabe, S., Uematsu, S., Akira, S., Uchiyama, Y., Takahashi, R., Misawa, H., Yamanaka, K. Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes. Cell Death Differ. 25(12):2130-2146, 2018.

111. .Eguchi, T., Kuwabara, T., Sakurai, M., Komori, T., Fujimoto, T., Ito, G., Yoshimura, S., Harada, A., Fukuda, M., Koike, M., Iwatsubo, T. LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc. Natl. Acad. Sci. U S A 115(39):E9115-E9124, 2018.

110. Osonoi, Y., Mita, T., Azuma, K., Nakajima, K., Matsuyama, A., Goto, H., Nishida, Y., Miyatsuka, T., Fujitani, Y., Koike, M., Mitsumata, M., Watada, H. Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis. Autophagy 14(11):1991-2006, 2018.

109. Shimada, Y., Shimura, H., Tanaka, R., Yamashiro, K., Koike, M., Uchiyama, Y., Urabe, T., Hattori, N. Phosphorylated recombinant HSP27 protects the brain and attenuates blood-brain barrier disruption following stroke in mice receiving intravenous tissue-plasminogen activator. PLoS One 13(5):e0198039, 2018.

108. Ogawa, M., Matsuda, R., Takada, N., Tomokiyo, M., Yamamoto, S., Shizukuishi, S., Yamaji, T., Yoshikawa, Y., Yoshida, M., Tanida, I., Koike, M., Murai, M., Morita, H., Takeyama, H., Ryo, A., Guan, JL., Yamamoto, M., Inoue, J., Yanagawa, T., Fukuda, M., Kawabe, H., Ohnishi, M. Mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination. Cell Microbiol. 20(8):e12846, 2018.

107. Tanida-Miyake, E., Koike, M., Uchiyama, Y., Tanida, I. Optimization of mNeonGreen for Homo sapiens increases its fluorescent intensity in mammalian cells. Plos One 13(1):e0191108, 2018.

106. Takakura, K., Ito, S., Sonoda, J., Tabata, K., Shiozaki, M., Nagai, K., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T. Cordyceps militaris improves the survival of Dahl salt-sensitive hypertensive rats possibly via influences of mitochondria and autophagy functions. Heliyon 3(11):e00462, 2017.

105. Tsuiji, H., Inoue, I., Takeuchi, M., Furuya, A., Yamakage, Y., Watanabe, S., Koike, M., Hattori, M., Yamanaka, K. TDP-43 accelerates age-dependent degeneration of interneurons. Sci. Rep. 7(1):14972, 2017.

104. Iwamoto, S., Koga, T., Ohba, M., Okuno, T., Koike, M., Murakami, A., Yokomizo, T. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing 12-hydroxyheptadecatrienoic acid, an endogenous ligand for leukotriene B4 receptor 2, BLT2. Sci. Rep. 7(1):13267, 2017.

103. Inoshita, T., Arano, T., Hosaka, Y., Meng, H., Umezaki, Y., Kosugi, S., Morimoto, T., Koike, M., Chang, HY., Imai, Y., Hattori, N. Vps35 in cooperation with LRRK2 regulates neuronal synaptic functions through the endosomal pathway in Drosophila. Hum. Mol. Genet. 26(15):2933-48, 2017.

102. Koike, M., Shibata, M., Sunabori, T., Yamaguchi, J., Sakimura, K., Komatsu, M., Tanaka, K., Uchiyama, Y. Purkinje cells are more vulnerable to the specific depletion of cathepsin D than to that of Atg7. Am. J. Pathol. 187(7):1586-600, 2017.

101. Ishimoto, T.*, Ninomiya, K.*, Inoue, R., Koike, M., Uchiyama, Y., Mori, H. Mice lacking BCAS1, a novel myelin-associated protein, display schizophrenia-like abnormal behaviors, and up-regulation of inflammatory genes in the brain. Glia 65(5):727-39, 2017. (*These authors contributed equally to this work)

100. Koike, M., Kawahara, A., Shibata, M., Uchiyama, Y. Induction of autophagy in the hippocampus after hypoxic-ischemic injury to neonatal rats. Arch. Histol. Cytol. 77(1):13-23, 2017.

99. Ichimura, K., Kakuta, S., Kawasaki, Y., Miyaki, T., Nonami, T., Miyazaki, N., Enomoto, S., Arai, S., Koike, M., Murata, K., Sakai, T. Morphological process of podocyte development revealed by block-face scanning electron microscopy. J. Cell Sci. 130(1):132-142, 2017.

98. Tsuboyama, K.*, Koyama-Honda, I.*, Sakamaki, Y., Koike, M., Morishita, H., Mizushima, N. The ATG conjugation systems are important for degradation of the inner autophagosomal membrane. Science 354(6315):1036-41, 2016. (*These authors contributed equally to this work)

97. Yamanaka, T., Tosaki, A., Miyazaki, H., Kurosawa, M., Koike, M., Uchiyama, Y., Maity, SN., Misawa, H., Takahashi, R., Shimogori, T., Hattori, N., Nukina, N. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Sci. Rep. 6:34575, 2016.

96. Sato, S., Koike, M., Funayama, M., Ezaki, J., Fukuda, T., Ueno, T., Uchiyama, Y., Hattori, N. Lysosomal storage of subunit c of mitochondrial ATP synthase in brain-specific ATP13a2-deficient mice. Am. J. Pathol. 186(12):3074-82, 2016.

95. Hadano, S., Mitsui, S., Pan, L., Otomo, A., Kubo, M., Sato, K., Ono, S., Onodera, W., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, HF., Yoshii, F. Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: Cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. Hum. Mol. Genet. 25(15):3321-40, 2016.

94. Sunabori, T., Koike, M., Asari, A., Oonuki, Y., Uchiyama, Y. Suppression of ischemia-induced hippocampal pyramidal neuron death by hyaluronan tetrasaccharide through inhibition of Toll-like receptor 2 signaling pathway. Am. J. Pathol. 186(8):2143-51, 2016.

93. Morales, J., Hashimoto, M.,Williams, T., Hirawake-Mogi, H., Makiuchi, T., Tsubouchi, A., Kaga, N., Taka, H., Fujimura, T., Mita, T., Koike, M., Bringaud, F., Concepción, J., Hashimoto, T., Embley, M., Nara, T. Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids. Proceedings of the Royal Society B 283(1830), 2016.

92. Shibata, M., Koike, M., Kusumi, S., Sato, N., Uchiyama, Y. A specific tripeptidyl substrate for tripeptidyl peptidase activity is effectively hydrolyzed by alanyl aminopeptidase/aminopeptidase N/CD13 in the rat kidney. Arch Histol Cytol. 76(1):1-8, 2016.

91. Sekine S.*, Yao, A.*, Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K., Ichijo, H. PGAM5 deficiency confers resistance against metabolic stress in mice. EBioMedicine 5:82-92, 2016. (*These authors contributed equally to this work)

90. Yamada, D., Saiki, S., Furuya, N., Ishikawa, K., Imamichi, Y., Kambe, T., Fujimura, T., Ueno, T., Koike, M., Hattori, N. Lysosomal neutralization triggered by Zn2+ accumulation through ZnT2 inhibits autophagy. Biochem. Biophys. Res. Commun. 471(1):109-16, 2016.

89. Yamamoto-Nonaka K., Koike, M., Asanuma, K., Akiba-Takagi, M., Trejo, JA., Seki, T., Hidaka, T., Ichimura, K., Sakai, T., Tada, N., Ueno, T., Uchiyama, Y., Tomino, Y. Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD. J. Am. Soc. Nephrol. 27(9):2685-700, 2016.

88. Xie, C., Ginet, V., Sun, Y., Koike, M., Zhou, K., Li, T., Li, H., Li, Q., Wang, X., Uchiyama, Y., Truttmann, AC., Kroemer, G., Puyal, J., Blomgren, K., Zhu, C. Neuroprotection by selective neuronal deletion of autophagy-related gene ATG7 in neonatal brain injury. Autophagy 12(2):410-23, 2016.

87. Mori, J. *, Tang, H. *, Kawabata, A., Koike, M., Mori, Y. Human herpesvirus 6A U14 is important for virus maturation. J. Virol. 90(3):1677-81, 2015. (*These authors contributed equally to this work)

86. Fuse, A.*, Furuya, N.*, Kakuta, S., Inose, A., Sato, M., Koike, M., Saiki, S., Hattori, N. VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process. FEBS let 589(13):1430-6, 2015. (*These authors contributed equally to this work)

85. Rinchai, D., Riyapa, D., Buddhisa, S., Utispan, K., Titball, R.W., Stevens, P.M., Stevens, J.M., Ogawa, M., Tanida, I., Koike, M., Uchiyama, Y., Ato, M., Lertmemongkolchai, G. Macroautophagy is essential for killing of Burkholderia pseudomallei in human neutrophils. Autophagy 11(5):748-55, 2015.

84. Nanao, T.*, Koike, M.*, Yamaguchi, J., Sasaki, M., Uchiyama, Y. Cellular localization and tissue distribution of endogenous DFCP1 protein. Biomed. Res. 36(2):121-33, 2015. (*These authors contributed equally to this work)

83. Uemura, N., Koike, M., Asai, K., Kinoshita, M., Fujiwara-Ishikawa, T., Matsui, H., Naruse, K., Sakamoto, N., Uchiyama, Y., Todo, T., Takeda S.I., Yamakado, H., Takahashi, R. Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. Plos Genet. 11(4):e1005065.

82. Ichimura, K., Miyazaki, N., Sadayama, S., Murata, K., Koike, M., Nakamura, K., Ohta, K., Sakai, T. Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy. Sci. Rep. 5:8993.

81. Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu A., Koya, I., Yoshida, R., Kudoh, J., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Nakamura, M., Okano, H. Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. Stem Cell Rep. 4(3):360-73.

80. Asano, T.*, Koike, M.*, Sakata, S., Takeda, Y., Nakagawa, T., Hatano, T., Ohashi, S., Funayama, M., Yoshimi, K., Asanuma, M., Toyokuni, S., Mochizuki, S., Uchiyama, Y., Hattori, N., Iwai, K. Iron induces mitochondrial damage that recruits parkin. Neurosci. Lett. 588:29-35, 2015. (*These authors contributed equally to this work)

79. Ueno, Y., Koike, M., Shimada, Y., Shimura, H., Uchiyama, Y., Hattori, N., Urabe, T. L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain. J. Cereb. Blood Flow Metab. 35(3):382-91, 2015.

78. Suyama, M.*, Koike, M.*, Asaoka, D., Mori, H., Oguro, M., Ueno, T., Nagahara, A., Watanabe, S. Uchiyama, Y. Increased immunoreactivity of cathepsins in the rat esophagus under chronic acid reflux esophagitis. J. Histochem. Cytochem. 62(9):645-60, 2014. (*These authors contributed equally to this work)

77. Ueshima S., Nishida, T., Koike, M., Matsuda, H., Sawa, Y., Uchiyama, Y. Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal motility under endotoxemia of mice. Biomed. Res. 35(4):251-62, 2014.

76. Shigihara, N.*, Fukunaka, A.*, Hara, A.*, Komiya, K., Honda, A., Uchida, T., Abe, H., Toyofuku, Y., Tamaki, M., Ogihara, T., Miyatsuka, T., Hiddinga, HJ, Sakagashira. S., Koike, M., Uchiyama, Y., Yoshimori, T., Eberhardt, NL, Fujitani, Y.*, Watada, H. Human IAPP-induced pancreatic beta-cell toxicity and its regulation by autophagy. J. Clin. Invest. 124(8):3634-44, 2014. (*These authors contributed equally to this work)

75. Bartolomé, A., Kimura-Koyanagi, M., Asahara, S., Guillén, C., Teruyama, K., Inoue, H., Shimizu, S., Kanno, A., García-Aguilar, A., Koike, M., Uchiyama, Y., Benito, M., Noda, T., Kido, Y. Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes 63(9):2996-3008, 2014.

74. Ishikawa K., Saiki, S., Furuya, N., Yamada, D., Imaichi, Y., Li, Y., Kawajiri, S., Sasaki, H., Koike, M., Tsuboi, Y., Hattori N. p150glued-associated disorders are caused by activation of intrinsic apoptotic pathway. Plos One 9(4):e94645, 2014.

73. Yamanaka, T., Tosaki, A., Kurosawa, M., Matsumoto, G., Koike, M., Uchiyama, Y., Maity, S.N., Hattori, N., Nukina, N. Neuronal NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin/p62 accumulation and endoplasmic reticulum disorganization. Nat. Commun. 5:3354, 2014.

72. Awazawa, M., Futami, T., Kaneko, K., Osugi, M., Nakaya, K., Terai, I., Suzuki, R., Koike, M., Uchiyama, Y., Kadowaki, T., Ueki, K. Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis diabetes mellitus. Mol. Cell Biol. 34(7):1290-9, 2014.

71. Nonomura, K., Yamaguchi, Y., Hamachi, M., Koike, M., Uchiyama, Y., Nakazato, K., Mochizuki, A., Sakaue-Sawano, A., Miyawaki, A., Yoshida, H., Kuida, K., Miura, M. Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells. Dev. Cell 27(6):621-34, 2013.

70. Abe, H., Uchida, T., Hara, A., Mizukami, H., Komiya, K., Koike, M., Shigihara, N., Toyofuku, Y., Ogihara, T., Uchiyama, Y., Yagihashi, S., Fujitani, Y., Watada, H. Exendin-4 improves beta cell function in autophagy-deficient beta cells. Endocrinology 154(12):4512-24, 2013.

69. Okura, H., Kobayashi, T., Koike, M., Ohsawa, M., Zhang, D., Arai, H., Uchiyama, Y., Hino, O. Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway. Int. J. Oncol. 43(2):447-56, 2013.

68. Koike, M.*, Tanida, I.*, Nanao, T., Tada, N., Iwata, J., Ueno, T., Kominami, E., Uchiyama, Y. Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. PLoS One 8(5):e63568, 2013. (*These authors contributed equally to this work)

67. Matsui, H.*, Sato, F.*, Sato, S., Koike, M., Taruno, Y., Saiki, S., Funayama, M., Ito, H., Taniguchi, Y., Uemura, N., Toyoda, A., Sakaki, Y., Takeda, S., Uchiyama, Y., Hattori, N., Takahashi, R. ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. FEBS letters 587(9):1316-25, 2013. (*These authors contributed equally to this work)

66. Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Saftig, P., Peters, C., Nagata, S., Uchiyama, Y. Biogenesis and proteolytic processing of lysosomal DNase II. PLoS One 8(3):e59148, 2013.

65. Koike, M., Shibata, M., Ezaki, J., Peters, C., Saftig, P., Kominami, E., Uchiyama, Y. Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous system. Eur. J. Neurosci. 37(5):816-30, 2013.

64. Hayakawa, N., Shiozaki, M., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T. Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic functions. Eur. J. Cell Biol. 92(1):30-43, 2013.

63. Piao, X., Komazawa-Sakon, S., Nishida, T., Koike, M., Piao JH., Ehlken, H., Kurihara, H., Hara, M., van Rooijen, N., Schütz, G., Ohmuraya, M., Uchiyama, Y., Yagita, H., Okumura, K., He YW., Nakano, H. c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Sci. Signal 5 (255); ra93, 2012.

62. Tashiro Y.*, Urushitani, M.*, Inoue, H., Koike, M., Uchiyama, Y., Komatsu, M., Tanaka, K., Yamazaki, M., Abe, M., Misawa, H., Sakimura, K., Ito, H., Takahashi, R. Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis. J. Biol. Chem. in press. doi:10.1074/jbc.M112.417600 (*These authors contributed equally to this work)

61. Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., Takanashi, M., Funayama, M., Hirayama, A., Soga, T., Hishiki, T., Suematsu, M., Yagi, T., Ito, D., Kosakai, A., Hayashi, K., Shouji, M., Nakanishi, A., Suzuki, N., Mizuno, Y., Mizushima, N., Amagai, M., Uchiyama, Y., Mochizuki, H., Hattori, N., Okano, H. Mitochondrial dysfunction with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain. Molecular Brain 5(1):35, 2012.

60. Unno, T., Wakamori, M., Koike, M., Uchiyama, Y., Ishikawa, K., Kubota, H., Yoshida, T., Sasakawa, H., Peters, C., Mizusawa, H., Watase, K. The development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6. Proc. Natl. Acad. Sci. USA 109(43):17693-8, 2012.

59. Sekine, S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K., Ichijo, H. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. J. Biol. Chem. 287(41):34635-45, 2012.

58. Mori, H.*, Koike, M.*, Gotow, T., Ichimura, K., Asaoka, D., Oguro, M., Nagahara, A., Ueno, T., Uchiyama, Y., Watanabe, S. Ultrastructural analyses of the rat esophageal stratified epithelium under normal conditions and chronic reflux esophagitis. Arch. Histol. Cytol. 73(4+5), 199-214, 2010+2011. (*These authors contributed equally to this work)

57. Nori, S., Okada, Y., Yasuda, A., Tsuji, O., Takahashi, Y., Kobayashi, Y., Fujiyoshi, K., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Yamanaka, S., Nakamura, M., Okano, H. Grafted human induced pluripotent stem-cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice. Proc. Natl. Acad. Sci. U S A 108(40): 16825-30, 2011.

56. Uchida, Y., Hasegawa, J., Chinnapen, D., Inoue, T., Okazaki, S., Kato, R., Wakatsuki, S., Misaki, R., Koike, M., Uchiyama, Y., Iemura, S., Natsume, T., Kuwahara, R., Nakagawa, T., Nishikawa, K., Mukai, K., Miyoshi, E., Taniguchi, N., Sheff, D., Lencer, W.I., Taguchi, T., Arai H. Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc. Natl. Acad. Sci. U S A 108(38): 15846-51, 2011.

55. Koyanagi, M., Asahara, S., Matsuda, T., Hashimoto, N., Shigeyama, Y., Shibutani, Y., Kanno, A., Fuchita, M., Mikami, T., Hosooka, T., Inoue, H., Matsumoto, M., Koike, M., Uchiyama, Y., Noda, T., Seino, S., Kasuga, M., Kido, Y. Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. PLoS One 6(8): e23238, 2011.

54. Shiozaki, M., Hayakawa, N., Shibata, M., Koike, M., Uchiyama, Y., Gotow, T. Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice. Histochem. Cell Biol. 136(4): 475-89, 2011.

53. Oguro, M., Koike, M., Ueno, T., Asaoka, D., Mori, H., Nagahara, A., Uchiyama, Y., Watanabe, S. Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease. J. Gastroenterol. 46(5): 629-38, 2011.

52. Komiya, K., Uchida, T., Ueno, T., Koike, M., Abe, H., Hirose, T., Kawamori, R., Uchiyama, Y., Kominami, E., Fujitani, Y., Watada, H. Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway. Biochem. Biophys. Res. Commun. 401(4): 561-7; 2010.

51. Kaneko, N., Marin, O., Koike, M., Hirota, Y., Uchiyama, Y., Wu, J.Y., Lu, Q., Tessier-Levigne, M., Alvarez-Buylla, A., Okano, H., Rubenstein, J.L., Sawamoto, K. New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron 67(2): 213-23; 2010.

50. Sasaki, K., Hamasaki, J., Koike, M., Hirano, Y., Komatsu, M., Uchiyama, Y., Tanaka, K., Murata, S. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol. Cell Biol. 30(15): 3864-74; 2010.

49. Hadano, S., Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Akatsuka, A., Koike, M., Aoki, M., Uchiyama, Y., Itoyama, Y., Ikeda, J.E. Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One 5(3): e9805; 2010.

48. Shimada, N., Ohno-Matsui, K., Iseki, S., Koike, M., Uchiyama, Y., Wang, J., Yoshida, T., Sato, T., Peters, C., Mochizuki, M., Morita, I. Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization. Am. J. Pathol. 176(5): 2571-80; 2010.

47. Shibata, M., Yoshimura, K., Tamura, H., Ueno, T., Nishimura, T., Inoue, T., Sasaki, M., Koike M., Arai, H., Kominami, E., Uchiyama, Y. LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation. Biochem. Biophys. Res. Commun. 393(2): 274-9; 2010.

46. Tamura, H., Shibata, M., Koike, M., Sasaki, M., Uchiyama, Y. Atg9A protein, an autophagy-related membrane protein, is localized in the neurons of mouse brains. J. Histochem. Cytochem. 58(5): 443-53; 2010.

45. Matsuda, T., Kido, Y., Asahara, S., Kaisho, T., Tanaka, T., Hashimoto, N., Shigeyama, Y., Takeda, A., Inoue, T., Shibutani, Y., Koyanagi, M., Hosooka, T., Matsumoto, M., Inoue, H., Uchida, T., Koike, M., Uchiyama, Y., Akira, S., Kasuga, M. Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J. Clin. Invest. 120(1): 115-26; 2010.

44. Maejima, Y., Sedbazar, U., Suyama, S., Kohno, D., Onaka, T., Takano, E., Yoshida, N., Koike, M., Uchiyama, Y., Fujiwara, K., Takahashi, N., Horvath, T.L., Dietrich, M.O., Tanaka, S., Dezaki, K., Oh-I, S., Hashimoto, K., Shimizu, H., Nakata, M., Mori, M., Yada, T. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab. 10(5): 355-65; 2009.

43. Sugita, S., Horie, S., Nakamura, O., Maruyama, K., Takase, H., Usui, Y., Takeuchi, M., Ishidoh, K., Koike, M., Uchiyama, Y., Peters, C., Yamamoto, Y., Mochizuki, M. Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. J. Immunol. 183(8): 5013-22; 2009.

42. Shibata, M.*, Yoshimura, K.*, Furuya, N., Koike, M., Ueno, T., Komatsu, M., Arai, H., Tanaka, K., Kominami, E., Uchiyama, Y. The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem. Biophys. Res. Commun. 382(2): 419-23; 2009. (*These authors contributed equally to this work)

41. Nada, S.*, Hondo, A. *, Kasai, A.*, Koike, M.*, Saito, K., Uchiyama, Y., Okada, M. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. EMBO J. 28(5): 477-89; 2009. (*These authors contributed equally to this work)

40. Gotoh, K., Lu, Z., Morita, M., Shibata, M., Koike, M., Waguri, S., Dono, K., Kominami, E., Sugioka, A., Monden, M., Uchiyama, Y. Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. Autophagy 5(3): 351-60; 2009.

39. Miyamoto, K., Shiozaki, M., Shibata, M., Koike, M., Uchimaya, Y., Gotow, T. Very-high-dose alpha-tocopherol supplementation increases blood pressure and causes possible adverse central nervous system effects in stroke-prone spontaneously hypertensive rats. J. Neurosci. Res. 87(2): 556-66; 2009.

38. Maeda, Y., Ide T., Koike, M., Uchiyama, Y., Kinoshita, T. GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus. Nat. Cell Biol. 10(10): 1135-45; 2008.

37. Saito, F., Kuwata, H., Oiki, E., Koike, M., Uchiyama, Y., Honda, K., Takeda, K. Inefficient phagosome maturation in infant macrophages. Biochem. Biophys. Res. Commun. 375(1): 113-8; 2008.

36. Mori, Y.*, Koike, M.*, Moriishi, E., Kawabata, A., Tang, H., Oyaizu, H., Uchiyama, Y., Yamanishi, K. Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway. Traffic 9(10): 1728-42; 2008. (*These authors contributed equally to this work)

35. Shiozaki, M., Yoshimura, K., Shibata, M., Koike, M., Matsuura, N., Uchiyama, Y., Gotow, T. Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Neuroscience 152(4): 924-41; 2008.

34. Takatsuka, A., Yagi, R., Koike, M., Oneyama, C., Nada, S., Schmedt, C., Uchiyama, Y., Okada, M. Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility. Dev. Biol. 315(2): 474-88; 2008.

33. Oppenheim, R.W., Blomgren, K., Ethell, D.W., Koike, M., Komatsu, M., Prevette, D., Roth, K.A., Uchiyama, Y., Vinsant, S., Zhu, C. Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy. J. Neurosci. 28(6): 1490-7; 2008.

32. Suzuki, C., Isaka, Y., Takabatake, Y., Tanaka, H., Koike, M., Shibata, M., Uchiyama, Y., Takahara S., Imai, E. Participation of autophagy in renal ischemia/reperfusion injury. Biochem. Biophys. Res. Commun. 368(1): 100-6; 2008.

31. Koike, M., Shibata, M., Tadakoshi, M., Gotoh, K., Komatsu, M., Waguri, S., Kawahara, N., Kuida, K., Nagata, S., Kominami, E., Tanaka, K., Uchiyama, Y. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am. J. Pathol. 172(2): 454-69; 2008.

30. Komatsu, M., Waguri, S., Koike, M., Sou, Y.S., Ueno, T., Hara, T., Mizushima, N., Iwata, J., Ezaki, J., Murata, S., Hamasaki, J., Nishito, Y., Iemura, S., Natsume, T., Yanagawa, T., Uwayama, J., Warabi, E., Yoshida, H., Ishii, T., Kobayashi, A., Yamamoto, M., Yue, Z., Uchiyama, Y., Kominami, E., Tanaka, K. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131(6): 1149-63; 2007.

29. Somboonthum, P., Yoshii, H., Okamoto, S., Koike, M., Gomi, Y., Uchiyama, Y., Takahashi, M., Yamanishi, K., Mori, Y. Generation of a recombinant Oka varicella vaccine expressing mumps virus hemagglutinin-neuraminidase protein as a polyvalent live vaccine. Vaccine 25(52): 8741-55; 2007.

28. Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., Nagata, S. Identification of Tim-4 as a phosphatidylserine receptor. Nature 450(7168): 435-9; 2007.

27. Iwai, K., Koike, M., Ohshima, S., Miyatake, K., Uchiyama, Y., Saeki, Y., Ishii, M. RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway. J. Bone Miner. Res. 22(10): 1612-20; 2007.

26. Nakahara, M., Nagasaka, A., Koike, M., Uchida, K., Kawane, K., Uchiyama, Y., Nagata, S. Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens. FEBS J. 274(12): 3055-64; 2007.

25. Yae, K., Keng V.W., Koike, M., Yusa, K., Kouno, M., Uno, Y., Kondoh, G., Gotow, T., Uchiyama, Y., Horie, K., Takeda, J. Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth. Mol. Cell Biol. 26(16): 6185-96; 2006.

24. Yoshimura, K., Shibata, M., Koike, M., Gotoh, K., Fukaya, M., Watanabe, M., Uchiyama, Y. Effects of RNA interference of Atg4B on the limited proteolysis of LC3 in PC12 cells and expression of Atg4B in various rat tissues. Autophagy 2(3): 200-8; 2006.

23. Ishii, M., Iwai K., Koike, M., Ohshima, S., Kudo-Tanaka, E., Ishii, T., Mima, T., Katada, Y., Miyatake, K., Uchiyama, Y., Saeki, Y. RANKL-induced expression of tetraspanin CD9 in lipid raft membrane microdomain is essential for cell fusion during osteoclastogenesis. J. Bone Miner. Res. 21(6): 965-76; 2006.

22. Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441(7095): 880-4; 2006.

21. Koike, M., Shibata, M., Waguri, S., Yoshimura, K., Tanida, I., Kominami, E., Gotow, T., Peters, C., von Figura, K., Mizushima, N., Saftig, P., Uchiyama, Y. Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am. J. Pathol. 167(6): 1713-28; 2005.

20. Yoshida, H., Kawane, K., Koike, M., Mori, Y., Uchiyama, Y., Nagata, S. Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells. Nature 437(7059): 754-8; 2005.

19. Takemoto, M., Koike, M., Mori, Y., Yonemoto, S., Sasamoto, Y., Kondo, K., Uchiyama, Y., Yamanishi, K. Human herpesvirus 6 open reading frame U14 protein and cellular p53 interact with each other and are contained in the virion. J. Virol. 79(20): 13037-46; 2005.

18. Shimizu, T., Hayashi, Y., Yamasaki, R., Yamada, J., Zhang, J., Ukai, K., Koike, M., Mine, K., von Figura, K., Peters, C., Saftig, P., Fukuda, T., Uchiyama, Y., Nakanishi, H. Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice. J. Neurochem. 94(3): 680-90; 2005.

17. Lu, Z., Dono, K., Gotoh, K., Shibata, M., Koike, M., Marubashi, S., Miyamoto, A., Takeda, Y., Nagano, H., Umeshita, K., Uchiyama, Y., Monden, M. Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation. Arch. Histol. Cytol. 68(1): 71-80; 2005.

16. Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., Nagata, S. Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304(5674): 1147-50, 2004.

15. Mori, Y., Akkapaiboon, P., Yonemoto, S., Koike, M., Takemoto, M., Sadaoka, T., Sasamoto, Y., Konishi, S., Uchiyama, Y., Yamanishi, K. Discovery of a second form of tripartite complex containing gH-gL of human herpesvirus 6 and observations on CD46. J. Virol. 78(9): 4609-16, 2004.

14. Kobayashi, K., Takahashi, M., Matsushita, N., Miyazaki, J., Koike, M., Yaginuma, H., Ohsumi, N., Kaibuchi, K., Kobayashi, K. Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J. Neurosci. 24(14): 3480-8; 2004.

13. Ohsawa, Y., Zhang, G., Kametaka, S., Shibata, M., Koike, M., Waguri, S., Uchiyama, Y. Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues. Arch. Histol. Cytol. 66(4): 367-81; 2003.

12. Ezaki, J., Takeda-Ezaki, M., Koike, M., Ohsawa, Y., Taka, H., Mineki, R., Murayama, K., Uchiyama, Y., Ueno, T., Kominami, E. Characterization of Cln3p, the gene product responsible for juvenile neuronal ceroid lipofuscinosis, as a lysosomal integral membrane glycoprotein. J. Neurochem. 87(5): 1296-308; 2003.

11. Koike, M., Shibata, M., Ohsawa, Y., Nakanishi, H., Koga, T., Kametaka, S., Waguri, S., Momoi, T., Kominami, E., Peters, C., von Figura, K., Saftig, P., Uchiyama, Y. Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol. Cell Neurosci. 22(2): 146-161; 2003.

10. Ishii, T., Tatekawa, T., Koseto, M., Ishii, M., Kobayashi, H., Koike, M., Fujii, T., Saeki, Y. A case of multicentric Castleman's disease demonstrating severe eosinophilia and enhanced production of interleukin-5. Eur. J. Haematol 70(2): 115-8; 2003.

9. Sakakibara, S., Nakamura, Y., Yoshida, T., Shibata, S., Koike, M., Takano, H., Ueda, S., Uchiyama, Y., Noda, T., Okano, H. RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc. Natl. Acad. Sci. U S A 99(23): 15194-9; 2002.

8. Koike, M., Shibata, M., Ohsawa, Y., Kametaka, S., Waguri, S., Kominami, E., Uchiyama, Y. The expression of tripeptidyl peptidase I in various tissues of rats and mice. Arch. Histol. Cytol. 65(3): 219-32; 2002.

7. Ogawa, Y., Sawamoto, K., Miyata, T., Miyao, S., Watanabe, M., Nakamura, M., Bregman, B.S., Koike, M., Uchiyama, Y., Toyama, Y., Okano, H. Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J. Neurosci. Res. 69(6): 925-33; 2002.

6. Shibata, M., Koike, M., Waguri, S., Zhang, G., Koga, T., Uchiyama, Y. Cathepsin D is specifically inhibited by deoxyribonucleic acids. FEBS letters. 517(1-3): 281-4; 2002.

5. Yoshikawa, M., Uchida, S., Ezaki, J., Rai, T., Hayama, A., Kobayashi, K., Kida, Y., Noda, M., Koike, M., Uchiyama, Y., Marumo, F., Kominami, E., Sasaki, S. CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells 7(6): 597-605; 2002.

4. Waguri, S., Kohmura, M., Kanamori, S., Watanabe, T., Ohsawa, Y., Koike, M., Tomiyama, Y., Wakasugi, M., Kominami, E., Uchiyama Y. Different distribution patterns of the two mannose 6-phosphate receptors in rat liver. J. Histochem. Cytochem. 49(11): 1397-405; 2001.

3. Nakanishi, H., Zhang, J., Koike, M., Nishioku, T., Okamoto, Y., Kominami, E., von Figura, K., Peters, C., Yamamoto, K., Saftig, P., Uchiyama, Y. Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. J. Neurosci. 21(19): 7526-33; 2001.

2. Yayoi, Y., Ohsawa Y., Koike, M., Zhang, G., Kominami E., Uchiyama Y. Specific localization of lysosomal aminopeptidases in type II alveolar epithelial cells of the rat lung. Arch. Histol. Cytol. 64(1): 89-97; 2001.

1. Koike, M.*, Nakanishi, H.*, Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., von Figura, K., Uchiyama, Y. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J. Neurosci. 20(18): 6898-906; 2000. (*These authors contributed equally to this work)

欧文総説

6. Parajuli, L.K., Koike, M. Three-dimensional structure of dendritic spines revealed by volume electron microscopy techniques. Front. Neuroanat. in press.

5. Klionsky, D.J. et al., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17(1):1-382, 2021.

4. Klionsky, D.J. et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1):1-222, 2016.

3. Klionsky, D.J. and 1268 authors. Guidelines for the use and interpretation of assays for monitoring autophagy (2nd edition). Autophagy 8(4) 445-544; 2012.

2. Uchiyama, Y., Shibata, M., Koike, M., Yoshimura, K., Sasaki, M. Autophagy-physiology and pathophysiology. Histochem. Cell Biol. 129(4): 407-20; 2008.

1. Uchiyama, Y., Koike, M., Shibata, M. Autophagic neuron death in neonatal brain ischemia/hypoxia. Autophagy 4(4): 404-8; 2008.

欧文図書
4. Tanida, I., Koike, M. John Wiley & Sons Inc., Techniques for studying autophagy. In: Autophagy, Infection, and the Immune Response. Ed. William Jackson, 19-32; 2014.

3. Komatsu, M., Koike, M., Ichimura Y., Uchiyama, Y. Genetic mouse models for elucidation of autophagy-lysosomal systems in neurons under physiologic and pathologic conditions. In: Autophagy of the Nervous System: Cellular Self-digestion in Neurons and Neurological Disease. Eds.Zhenyu Yue and Charleen T Chu, 176-204; 2012.

2. Uchiyama, Y., Koike M., Shibata, M. Springer Japan. Autophagy and cell death. In: Molecular imaging for integrated medical therapy and drug development. Eds. Nagara Tamaki and Yuji Kuge, 176-88; 2010.

1. Uchiyama, Y., Koike M., Shibata, M., Sasaki, M. Elsevier Inc. Autophagic neuron death. In: Methods Enzymol. Vol.453 (Autophagy in Disease and Clinical Applications, Part C) Ed. Daniel J. Klionsky, 33-51; 2009.

邦文著書
4. 小池正人「各種免疫電子顕微鏡法の実践」組織細胞化学2021(日本組織細胞化学会編集) (学際企画), 145-161, 2021.

3. 小池正人「TEMを使った免疫電子顕微鏡法の実践」組織細胞化学2018 (日本組織細胞化学会編集) (学際企画), 91-107, 2018.

2. 小池正人、内山安男.「リソソーム内の分解機構」オートファジー　生命をささえる細胞の自己分解システム (水島昇・吉森保編集) (化学同人), 67-76, 2012.

1. 小池正人「マウス低酸素-脳虚血負荷後の神経細胞死の遺伝学的検討」ブレインサイエンスレビュー2011 (伊藤正男・川合述史編集)（クバプロ） 149-68, 2011.

邦文総説

11. 小池正人.「パーキンソン病とリソソーム」生体の科学 73(3): 256-60; 2022.

10. 小池正人.「徳安法の基礎と応用」顕微鏡 56(3): 145-61; 2021.

9. 小池正人.「三次元電子顕微鏡法」医学のあゆみ272(9): 934-9; 2020.

8. 小池正人.「電子顕微鏡三次元立体再構築による組織細胞の観察の有用性と今後の課題」LISA 25(1): 79-89; 2018.

7. 小池正人.「ライソゾーム分解系」生体の科学 66(5): 496-7; 2015.

6. 小池正人、内山安男.「神経性セロイドリポフスチン蓄積症における”異常なリソソーム”のオートファジーによる処理」生体の科学 63(5): 505-4; 2012.

5. 小池正人、内山安男.「リソソームプロテアーゼの多様性とその病態生理学的役割」実験医学増刊号 29(12): 1903-8; 2011.

4. 小池正人、内山安男.「脳虚血とオートファジー, ユビキチン・プロテアソーム系の役割」医学のあゆみ231(5): 347-51; 2009.

3. 小池正人、内山安男.「オートファジーの超微形態観察」臨床検査 53(12): 1535-41; 2009.

2. 小池正人、内山安男.「オートファジーと神経細胞死」医学のあゆみ 225(6): 491-4; 2008.

1. 内山安男、小池正人. 「カテプシンD遺伝子欠損は神経性セロイドリポフスチン蓄積症の原因の一つか」遺伝子医学 5(2): 278-82; 2001.

紀要
3. 小池正人：リソソーム膜蛋白 p18 欠損による髄鞘形成不全の機構．上原記念生命科学財団研究報告集 30:1-5, 2016

2. 小池正人、柴田昌宏、小松雅明、石井哲郎、田中啓二、木南英紀、内山安男、「進行性ミオクロニーてんかんの一種である神経性セロイドリポフスチン蓄積症のモデルマウスにおけるてんかん発生機序の解明」てんかん治療研究振興財団研究年報　 21:49-56; 2010.

1. 榊原伸一、中村由紀、小池正人、高野洋志、佐藤均、内山安男、野田哲生、岡野栄之、「ノックアウトマウスを用いたMusashi1(Msi1)の機能及び水頭症発症機序の解析」厚生科学研究費補助金特定疾患対策研究事業難治性水頭症調査研究班平成11年度研究報告書 2000年3月 16-25頁

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小池 正人（コイケ マサト）

小池正人（コイケマサト）