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研究業績詳細

橋本 良太(ハシモト リョウタ)

研究テーマ 骨髄細胞の生理機能
研究業績(論文) 1.Mouse bone marrow stromal cells differentiate into functional smooth muscle cells. Hashimoto R, et al. The Journal of Japanese College of Angiology. 2008: 48: 299-306
2.T-Type Ca2+ channel blockers increase smooth muscle progenitor cells and endothelial progenitor cells in bone marrow stromal cells in culture by suppression of cell death. Hashimoto R, et al. Annals of Vascular Diseases. 2010: 3: 117-126
3.Enhanced accumulation of adipocytes in bone marrow stromal cells in the presence of increased extracellular and intracellular [Ca²⁺].Hashimoto R, et al. Biochemical and Biophysical Research Communications. 2012: 423: 672-678
4.Bone marrow-derived regenerated smooth muscle cells have ion channels and properties characteristic of vascular smooth muscle cells. Hashimoto R, et al. Journal of Stem Cell Research & Therapy. 2015: 5: 257
5.Increased Extracellular and Intracellular Ca2+ Lead to Adipocyte Accumulation in Bone Marrow Stromal Cells by Different Mechanisms. Hashimoto R, et al. Biochemical and Biophysical Research Communications. 2015. 457: 647-652
6.Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: Implication in chronic hypoxia-induced pulmonary hypertension. Hashimoto R, et al. Am J Physiol Heart Circ Physiol. 2017: 313: H293–H303
7.High extracellular Ca²⁺ enhances the adipocyte accumulation of bone marrow stromal cells through a decrease in cAMP. Hashimoto R, et al. Cell Calcium. 2017: 67: 74-80
8.LPS enhances expression of CD204 through the MAPK/ERK pathway in murine bone marrow macrophages. Hashimoto R, et al. Atherosclerosis. 2017: 266: 167-175
9.Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension. Hashimoto R and Gupte S. Adv Exp Med Biol. 2017: 967: 47-55
10.A simple method to increase the proportion of bone marrow-derived macrophages positive for M-CSFR using the reducing agent dithiothreitol (DTT). Hashimoto R, et al. MethodsX. 2018: 5: 1540-1548
11.Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Yoshikawa S, Oh-Hora M, Hashimoto R, Nagao T, Peters L, Egawa M, Ohta T, Miyake K, Adachi T, Kawano Y, Yamanishi Y, Karasuyama H. Sci Signal. 2019: 12: eaav2060
12.Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca2+-enhanced adipogenesis in bone marrow stromal cells. Hashimoto R, et al. J Physiol Sci. 2019: 69: 741-748
13.Extracellular Ca2+ in Bone Marrow. Hashimoto R. Adv Exp Med Biol. 2020: 1131: 1065-1078
14.A Chronic High-Fat Diet Exacerbates Contractile Dysfunction With Impaired Intracellular Ca2+ Release Capacity in the Skeletal Muscle of Aged Mice. Eshima H, Tamura Y, Kakehi S, Kakigi R, Hashimoto R, Funai K, Kawamori R, Watada H. J Appl Physiol (1985). 2020: 128: 1153-1162
15.JAK-STAT-dependent regulation of scavenger receptors in LPS-activated murine macrophages. Hashimoto R, et al. Eur J Pharmacol. 2020: 871: 172940
16.Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Am J Physiol Lung Cell Mol Physiol. 2020: 318: L773-L786
17.Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension. Hashimoto R, et al. Am J Physiol Lung Cell Mol Physiol. 2020: 318: L386-L401
18.G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation. Hashimoto R, et al. Vascul Pharmacol. 2022: 144:106976
19.Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2. Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R,
Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S. The EMBO Journal. 2022: 41: e111476
20.Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages. Hashimoto R, Koide H, Katoh Y. J Pharmacol Sci. 2023: 151: 46-53

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