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鶴井博理（ツルイヒロミチ）

研究テーマ	免疫学、画像分光学、蛋白質工学
研究業績（論文）	原著 Ando S, Matsuzawa Y, Tsurui Y, Mizutani T, Hall D, Kuroda Y., Stochastic modelling of the effects of human-bobility restriction and Viral infection characteristics on the spread of COVID-19. Scientific reports article number: 6856 (2021) Kobayashi T, Nakata K, Yajima I, Kato M, Tsurui H., Label-free imaging of melanoma with confocal photothermal microscopy: differentiation between malignant and benign tissue., Bioengineering 5:67-84, 2018 Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek Sjef, Hirose S., FcγRIIb on B cells and myeloid cells modulates B cell activation and autoantibody responses via different but synergistic pathways in Lupus-Prone Yaa mice, J Immunol, 201:3199-3210, 2018 Kobayashi T, Nakata K, and Tsurui H, Super-resolution photo-thermal microscopy with a nonlinear detection scheme. Nonlinear optics , 2017, doi.org/10.1364/NLO.2017.NF2A.4, Tsuchiya Y, Namiuchi Y, Wako H, Tsurui H., A study of CDR3 loop dynamics reveals distinct mechanisms of peptide recognition by T‐cell receptors exhibiting different levels of cross‐reactivity. Immunology, 153:466–478 2017 Kobayashi T, Sundaram D, Nakata K, Tsurui H, Gray-level co-occurrence matrix analysis of several cell types in mouse brain using resolution-enhanced photothermal microscopy. J. Biomed. Opt. 22, 036011, 2017 He J, Wang N, Tsurui H, Kato M, Iida M, Kobayashi T, Noninvasive, label-free, three-dimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue. Scientific Reports Online, 6:30209 doi:10.1038/srep30209, 2016 Ohtsuji M, Lin Q, Nishikawa K, Ohtsuji N, Okazaki H, Tsurui H, Amano H, Shirai T, Nishimoto N, Nishimura H, and Hirose S. IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcRIIB-deficient rheumatoid arthritis mouse model. Mod. Rheumatol. 2014, DOI:10.3109/14397595.2014.950035 Tsurui H, Takahashi T, Matsuda Y, Lin Q, Sato-Hayashizaki A, and Hirose S. Exhaustive characterization of TCR–pMHC binding energy estimated by the string model and Miyazawa-Jernigan matrix. General Med. 2014, DOI: 10.4172/2327-5146.1000126 Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, and Hirose S. TNF but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcRIIB-deficient mouse model. Mod. Rheumatol. 2014, DOI:10.3109/14397595.　2014.886351 Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H, Takai T, Shirai T, Takasaki Y and Hirose S. Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcRIIB-deficient C57BL/6 mice. Eur. J. Immunol. 43:770-778, 2013. Kitabatake M, Toda T, Kuwahara K, Igarashi H, Ohtsuji M, Tsurui H, Hirose S, and Sakaguchi N. Transgenic overexpression of G5PR that is normally augmented in centrocytes impairs the enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice. J. Immunol. 189:1193-1201, 2012. Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S. Presumptive role of 129 strain–derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fc receptor type IIb–deficient C57BL/6 genetic background. Arthritis & Rheumatism, 2011; 63:2930-2938 Lin Q Hou R, Sato A, Ohtsuji M, Ohtsuji N, Nishikawa K, Tsurui H, Amano H, Amano E, Sudo K, Nishimura H, Shirai T, Hirose S. Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus. J Autoimmunity. 2010; 34:356-363 Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y. FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice. Biochemical and Biophysical Research Communications. 2010 394:804-810 Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K, Hirose S. Ankylosing enthesitis associated with up-regulated IFN-gamma and IL-17 production in (BXSB X NZB) F(1) male mice: a new mouse model. Mod Rheumatol. 2009; Okamoto A, Fujio K, van Rooijien N, Tsuno NH, Takahshi K, Tsurui H, Hirose S, Elkon KB, Yamamoto K. Splenic phagocytes promote responses to nucleosomes in (NZB X NZW) F1 mice. J Immunol. 2008; 181(8):5264-71 Tsukamono K, Ohtsuji M, Shiroiwa W, Lin Q, Nakamura K, Tsurui H, Jiang Y, Sudo K, Nishimura H, Shirai T, Hirose S. Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains: possible involvement in systemic lupus erythematosus pathogenesis. J Immunol. 2008;; 180(7):4530-9 Nakamura K, Sato T, Ohashi A, Tsurui H, Hasegawa H. Role of a serotonin precursor in development of gut microvilli. Am J Pathol. 2008 ;172(2):333-44. Epub 2008 Jan 17. Nakamura K, Hirai H, Torashima T Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S. CD3 and immunoglobulin G Fc receptor regulate cerebellar functions. Mol Cell Biol. 2007; 27(14):5128-34 Shiroiwa W, Tsukamoto K, Ohtsuji M, Lin Q, Ida A, Kodera S, Ohtsuji N, Nakamura K, Tsurui H, Kinoshita K, Nishimura H, Shirai T, Hirose S. IL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus. Int Immunol. 2007; 19(2):175-83 Nakamura K, Koyama Y, Takahashi K, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Sugawara Y, Sawabe K, Ohashi A, Ohnuma T, Arai H, Nishimura H, Hasegawa H, Hirose S. Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating. J Mol Biol. 2006;363(2):345-54. Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, Ohtsuji M, Ohtsuji N, Shiroiwa W, Tsukamoto K, Amano H, Amano E, Kinoshita K, Sudo K, Nishimura H, Izui S, Shirai T, Hirose S. Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol. 2006;177(3):1646-54 Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S. Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci. 2006;26(2):530-4 Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S. Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. Eur J Immunol. 2004 Oct;34(10)2740-9 Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S. Dissectionof the role fo MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. Proc Natl Acad Sci USA. 2004 Sep;101(38)13838-43 Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Hirose S. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum Mol Genet. 2004;13(2):171-9 Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M, Hirose S, Tshirai T. A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. J Exp Med. 2003;198(3):497-503 Xiu Y, Nakamura K, Abe M, Li N, Wen XS, Jiang Y, Zhang D, Tsurui H, Matsuoka S, Hamano Y, Fujii H, Ono M, Takai T, Shimokawa T, Ra C, Shirai T, Hirose S. Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J Immunol. 2002; 169(8):4340-6 Tsurui H, Nishimura H, Hattori S, Hirose S, Okumura K, Shirai T.Seven-color fluorescence imagign of tissue samples based on Fourier spectroscopy and singular value decomposition. J Histochem Cytochem 2000;48(5):653-62 Hattori S, Nishimura S, Tsurui H, Kato M, Endo N, Abe M, Akakura S, Mitsui K, Ishikawa S, Hirose S, Shirai T. L-selectin-specific autoantibodies in murine lupus:possible involvment in abnormal homing and polyrization of CD4+ T cell subsets. J Immunol. 1998;161(3)1231-8 Hirose S, Yan K, Abe M, Jiang Y, Hamano Y, Tsurui H, Shirai T.Precursor B cells for autoantibody production in genomically Fas-intact autoimune disease are not subject to Fas-mediated immune elimination. Proc Natl Acad Sci USA 1997;94(17):9291-5 Miyazaki S, Shimura J, Hirose S, Sanokawa R, Tsurui H, Wakiya M, Sugawara H, Shirai T.Is structure flexibility of antigen-binding loops involved in the affinity maturation of anti-DNA antibodies? Int Immunol. 1997;9(5):771-7 Watanabe Y, Tsurui H, Ueda T, Furushima-Shimokawara R, Takamiya S, Kita K, Nishikawa K, Watanabe K. Primary sequence of mitochondrial tRNA(Arg) of a nematode Ascaris suum:occurrence of unmodified adenosine at the first positioon of the anticodon. Biochem Biophys Acta. 1997;1350(2):119-22 Jiang Y, Hirose S, Hamano Y, Kodera S, Tsurui H, Abe M, Terashima K, Ishikawa S, Shirai T. Mapping of a gene for the increased susceptibllity of B1 cells to Motto cell formation in murine autoimune disease. J Immunol. 1997;158(2):992-7 Nishimura H, Ihiskawa S, Nozawa S, Awaji M, Saito J, Abe M, Tokushima M, Kimoto M, Akakura S, Tsurui H, Hirose S, Shirai T. Effects of transgenic mixed-haplotype MHC class II molecules A alpha d A beta z on autoimmune disease in New Zealand mice. Int Immunol. 1996;8(6):9667-76 Nishimura H, Hattori S, Ueda G, Abe M, Yang K, Nozawa S, Okamoto H, Zhang D, Tsurui H, Hirose S, Shirai T. Functional CD4+ T cell subsets defined by expression of CD45RC and NTA260 antigens and age-associated polarization in murine lupus. Int Immunol. 1995;7(7):1115-23 Nishimura H, Munakata N, Hayashi K, Hayakawa M, Iwamoto H, Terayama S, Takahata Y, Kodera Y, Tsurui H, Shirai T. Polyethylene glycol-modified avidin: a novel agent for the selective extraction of biotinylated immune-complex in an aqueous two-phase system. J Biomater sci Polym Ed. 1995;7(3):289-96 Hirose S, Tsurui H, Nishimura H, Juang Y, Shirai T. Mapping of a gene for hypergammaglobulinemia to the distal region on chormosome $ in NZB mice and its contribution to systemic lupus erythematosus in (NZB x NZW)F1 mice. Int Immunol. 1994;6(12):1857-64 Watanabe Y, Tsurui H, Ueda T, Furushima R, Takamiya S, Kita K, Nishikawa K, Watanabe K. Primary and higer order structure of nematode (Ascaris suum) mitochondrial tRNAs lacking either the T or D stem. J Biol Chem 1994;221(1):166-72 Tsurui H, Kumazawa Y, Sanokawa R, Watanabe Y, Kuroda T, Wada A, Watanabe K, Shirai T. Batchwise purification of specific tRNAs by a solid-phase DNA probe. Anal Biochem. 1994;221(1):166-72 Shiota J, Nishimura H, Okamoto H, Yu B, Hattori S, Abe M, Okada T, Nozawa S, Tsurui H, Hirose S, Shirai T A unique murine CD43 epitope Lp-3: distinct distribution from another CD43 epitope S7. Cell Immunol. 1994;155(2):402-13 Hirose S, Wakiya M, Kawano-Nishi Y, Yi J, Sanokawa R, Taki S, Shimamura T, Kishimoto T, Tsurui H, Nishimura H, et al. Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus. Eur J Immunol. 1993;23(11):2813-20 Hara H, Yamaguchi T, Tahara H, Tsuyama N, Tsurui H, Ide T, Oda K. DNA-DNA subtractive cDNA cloning using oligo(dT)30-latex and PCR: identification of cellular genes which are overexpressed in senescent human diploid fibroblasts. Anal Biochem. 1993:214(1):58-64 Nakamura T, NakajimaT, Tsunoda S, Nakada S, Oda K, Tsurui H, Wada A. Induction of E1A-responsive negative factor for transcription of the fiboronectin gene in adenovirus E1-transformed rat cells. J Virol. 1992; 66(11):6436-50 Nishimura H, Hattori S, Abe M, Ueda G, Okamoto H, Tsurui H, Hirose S, Shirai T. Differential expression of three CD45 alternative structures on murin T cells:exon 6-dependent epitope as a marker for functional heterogeniety of CD4+ T cells. Int Immunol. 1992;4(8):923-30 Kumazawa Y, Yokogawa T, Tsurui H, Miura K, Watanabe K. Effect of higher-order structure of tRNAs on the stability of hybrids with oligodeoxyribonucleotides: separation of tRNA by an efficient solution hybridization. Nucleic Acids Res. 1992;20(9):2223-32 Tsurui H, Kim N, Umezawa Y, Kato S. Efficient cDNA cloning method using solid phase DNA probe. Nucleic Acids Symp Ser. 1992;(27):155-6 Hara E, Tsurui H, Shinozaki A, Nakada, S, Oda K. Cooperative effect of antisense-Rb and antisense-p53 oligoners on the extraction of life span in human diploid fibroblasts, TIG-1. Biochem Biophys Res Commun. 1991;179(1):528-34 Tsurui H, Kishimoto T, Sanokawa R, Shirai T. Precise discrimination among homologous sequences by DNA probe column chromatography. Nucleic Acids Symp Ser. 1991;(25):39-40 Tsurui H, Kumazawa Y, Sanokawa R, Watanabe K. Wada A, Shirai T. Sequence specific purification of a particular tRNA by solid-phase DNA probe. Nucleic Acids Symp Ser. 1991;(25):149-50 Tsurui H, Hara E, Oda K, Suyama A, Nakada S, Wada A. A rapid and efficient cloining method with a solid-phase DNA probe: application for cloning the 5'-flanking region of the gene encoding human fibronectin. Gene. 1990;88(2):233-9 Hara E, Kato T, Nakada S, Nakajima T, Tsurui H, Oda K. Construction of a subtracted cDNA library using oligo(dT)-latex. Nucleic Acid Symp Ser. 1990;(22):29-30 Tsurui H, Suyama A, Wada A. Temperature gradient DNA-probe column chromatography: as tools for detection and purification of particular DNAs and RNAs. Nucleic Acids Symp Ser. 1988;(19):49-52 Okada A, Nakanishi M, Tsurui H, Wada A, Terashima M, Osawa T. A hapten-induced conformational change accompanies the cryoprecipitation of an immunoglobulin. Mol Immunol. 1985; 22(6):715-8 Review (1) Tsurui H and Takahashi T. Prediction of T-cell epitope. J Pharmacol Sci. 2007; 105:299-316 著書 (1)Tsurui H and Takahashi T. Practical estimation of TCR-pMHC binding free-energy based on dielectric model and coarse-grained model. In Molecular Dynamics / Book2, InTech, in press. (2)鶴井　博理、佐野川　玲子、岸本　利彦「アフィニティーカラムによる核酸の分離精製」新生化学実験講座２　核酸Ⅰ　第９章　日本生化学会編　東京化学同人　１９９１年 169-192 (3)鶴井　博理、西村　裕之「遺伝子診断：新しい素材の応用の可能性」バイオコンジュゲート医薬品　第7章　稲田　祐二、谷本　剛編　廣川書店　１９９３年 147-169 (4)Wada A, Tsurui H, Suyama A. High Base-sequence-resolution extraction of DNA fragments by immobilized probe for high-efficiency gene cloning. Chap. 9 in Advanced techniques in chromosome research, ed. Adolf KW, Marcel Dekker Inc. 1991

研究テーマ

免疫学、画像分光学、蛋白質工学

研究業績（論文）

原著
Ando S, Matsuzawa Y, Tsurui Y, Mizutani T, Hall D, Kuroda Y., Stochastic modelling of the effects of human-bobility restriction and Viral infection characteristics on the spread of COVID-19. Scientific reports article number: 6856 (2021)

Kobayashi T, Nakata K, Yajima I, Kato M, Tsurui H., Label-free imaging of melanoma with confocal photothermal microscopy: differentiation between malignant and benign tissue., Bioengineering 5:67-84, 2018

Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek Sjef, Hirose S., FcγRIIb on B cells and myeloid cells modulates B cell activation and autoantibody responses via different but synergistic pathways in Lupus-Prone Yaa mice, J Immunol, 201:3199-3210, 2018

Kobayashi T, Nakata K, and Tsurui H, Super-resolution photo-thermal microscopy with a nonlinear detection scheme. Nonlinear optics , 2017, doi.org/10.1364/NLO.2017.NF2A.4,

Tsuchiya Y, Namiuchi Y, Wako H, Tsurui H., A study of CDR3 loop dynamics reveals distinct mechanisms of peptide recognition by T‐cell receptors exhibiting different levels of cross‐reactivity. Immunology, 153:466–478 2017

Kobayashi T, Sundaram D, Nakata K, Tsurui H, Gray-level co-occurrence matrix analysis of several cell types in mouse brain using resolution-enhanced photothermal microscopy. J. Biomed. Opt. 22, 036011, 2017

He J, Wang N, Tsurui H, Kato M, Iida M, Kobayashi T, Noninvasive, label-free, three-dimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue. Scientific Reports Online, 6:30209 doi:10.1038/srep30209, 2016

Ohtsuji M, Lin Q, Nishikawa K, Ohtsuji N, Okazaki H, Tsurui H, Amano H, Shirai T, Nishimoto N, Nishimura H, and Hirose S. IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcRIIB-deficient rheumatoid arthritis mouse model. Mod. Rheumatol. 2014, DOI:10.3109/14397595.2014.950035

Tsurui H, Takahashi T, Matsuda Y, Lin Q, Sato-Hayashizaki A, and Hirose S. Exhaustive characterization of TCR–pMHC binding energy estimated by the string model and Miyazawa-Jernigan matrix. General Med. 2014, DOI: 10.4172/2327-5146.1000126

Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, and Hirose S. TNF but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcRIIB-deficient mouse model. Mod. Rheumatol. 2014, DOI:10.3109/14397595.　2014.886351

Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H, Takai T, Shirai T, Takasaki Y and Hirose S. Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcRIIB-deficient C57BL/6 mice. Eur. J. Immunol. 43:770-778, 2013.

Kitabatake M, Toda T, Kuwahara K, Igarashi H, Ohtsuji M, Tsurui H, Hirose S, and Sakaguchi N. Transgenic overexpression of G5PR that is normally augmented in centrocytes impairs the enrichment of high-affinity antigen-specific B cells, increases peritoneal B-1a cells, and induces autoimmunity in aged female mice. J. Immunol. 189:1193-1201, 2012.

Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S. Presumptive role of 129 strain–derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fc receptor type IIb–deficient C57BL/6 genetic background. Arthritis & Rheumatism, 2011; 63:2930-2938

Lin Q Hou R, Sato A, Ohtsuji M, Ohtsuji N, Nishikawa K, Tsurui H, Amano H, Amano E, Sudo K, Nishimura H, Shirai T, Hirose S. Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus. J Autoimmunity. 2010; 34:356-363

Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y. FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice. Biochemical and Biophysical Research Communications. 2010 394:804-810

Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K, Hirose S. Ankylosing enthesitis associated with up-regulated IFN-gamma and IL-17 production in (BXSB X NZB) F(1) male mice: a new mouse model. Mod Rheumatol. 2009;

Okamoto A, Fujio K, van Rooijien N, Tsuno NH, Takahshi K, Tsurui H, Hirose S, Elkon KB, Yamamoto K. Splenic phagocytes promote responses to nucleosomes in (NZB X NZW) F1 mice. J Immunol. 2008; 181(8):5264-71

Tsukamono K, Ohtsuji M, Shiroiwa W, Lin Q, Nakamura K, Tsurui H, Jiang Y, Sudo K, Nishimura H, Shirai T, Hirose S. Aberrant genetic control of invariant TCR-bearing NKT cell function in New Zealand mouse strains: possible involvement in systemic lupus erythematosus pathogenesis. J Immunol. 2008;; 180(7):4530-9

Nakamura K, Sato T, Ohashi A, Tsurui H, Hasegawa H.
Role of a serotonin precursor in development of gut microvilli.
Am J Pathol. 2008 ;172(2):333-44. Epub 2008 Jan 17.

Nakamura K, Hirai H, Torashima T Miyazaki T, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Tsukamoto K, Nishimura H, Ono M, Watanabe M, Hirose S.
CD3 and immunoglobulin G Fc receptor regulate cerebellar functions. Mol Cell Biol. 2007; 27(14):5128-34

Shiroiwa W, Tsukamoto K, Ohtsuji M, Lin Q, Ida A, Kodera S, Ohtsuji N, Nakamura K, Tsurui H, Kinoshita K, Nishimura H, Shirai T, Hirose S.
IL-4Ralpha polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus. Int Immunol. 2007; 19(2):175-83

Nakamura K, Koyama Y, Takahashi K, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Sugawara Y, Sawabe K, Ohashi A, Ohnuma T, Arai H, Nishimura H, Hasegawa H, Hirose S.
Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating. J Mol Biol. 2006;363(2):345-54.

Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, Ohtsuji M, Ohtsuji N, Shiroiwa W, Tsukamoto K, Amano H, Amano E, Kinoshita K, Sudo K, Nishimura H, Izui S, Shirai T, Hirose S.
Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus. J Immunol. 2006;177(3):1646-54

Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S.
Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels. J Neurosci. 2006;26(2):530-4

Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S.
Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus.
Eur J Immunol. 2004 Oct;34(10)2740-9

Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S.
Dissectionof the role fo MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.
Proc Natl Acad Sci USA. 2004 Sep;101(38)13838-43

Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Hirose S.
Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus.
Hum Mol Genet. 2004;13(2):171-9

Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M, Hirose S, Tshirai T.
A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. J Exp Med. 2003;198(3):497-503

Xiu Y, Nakamura K, Abe M, Li N, Wen XS, Jiang Y, Zhang D, Tsurui H, Matsuoka S, Hamano Y, Fujii H, Ono M, Takai T, Shimokawa T, Ra C, Shirai T, Hirose S.
Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J Immunol. 2002; 169(8):4340-6

Tsurui H, Nishimura H, Hattori S, Hirose S, Okumura K, Shirai T.Seven-color fluorescence imagign of tissue samples based on Fourier spectroscopy and singular value decomposition. J Histochem Cytochem 2000;48(5):653-62

Hattori S, Nishimura S, Tsurui H, Kato M, Endo N, Abe M, Akakura S, Mitsui K, Ishikawa S, Hirose S, Shirai T.
L-selectin-specific autoantibodies in murine lupus:possible involvment in abnormal homing and polyrization of CD4+ T cell subsets. J Immunol. 1998;161(3)1231-8

Hirose S, Yan K, Abe M, Jiang Y, Hamano Y, Tsurui H, Shirai T.Precursor B cells for autoantibody production in genomically Fas-intact autoimune disease are not subject to Fas-mediated immune elimination. Proc Natl Acad Sci USA 1997;94(17):9291-5

Miyazaki S, Shimura J, Hirose S, Sanokawa R, Tsurui H, Wakiya M, Sugawara H, Shirai T.Is structure flexibility of antigen-binding loops involved in the affinity maturation of anti-DNA antibodies? Int Immunol. 1997;9(5):771-7

Watanabe Y, Tsurui H, Ueda T, Furushima-Shimokawara R, Takamiya S, Kita K, Nishikawa K, Watanabe K.
Primary sequence of mitochondrial tRNA(Arg) of a nematode Ascaris suum:occurrence of unmodified adenosine at the first positioon of the anticodon. Biochem Biophys Acta. 1997;1350(2):119-22

Jiang Y, Hirose S, Hamano Y, Kodera S, Tsurui H, Abe M, Terashima K, Ishikawa S, Shirai T. Mapping of a gene for the increased susceptibllity of B1 cells to Motto cell formation in murine autoimune disease.
J Immunol. 1997;158(2):992-7

Nishimura H, Ihiskawa S, Nozawa S, Awaji M, Saito J, Abe M, Tokushima M, Kimoto M, Akakura S, Tsurui H, Hirose S, Shirai T. Effects of transgenic mixed-haplotype MHC class II molecules A alpha d A beta z on autoimmune disease in New Zealand mice. Int Immunol. 1996;8(6):9667-76

Nishimura H, Hattori S, Ueda G, Abe M, Yang K, Nozawa S, Okamoto H, Zhang D, Tsurui H, Hirose S, Shirai T.
Functional CD4+ T cell subsets defined by expression of CD45RC and NTA260 antigens and age-associated polarization in murine lupus. Int Immunol. 1995;7(7):1115-23

Nishimura H, Munakata N, Hayashi K, Hayakawa M, Iwamoto H, Terayama S, Takahata Y, Kodera Y, Tsurui H, Shirai T.
Polyethylene glycol-modified avidin: a novel agent for the selective extraction of biotinylated immune-complex in an aqueous two-phase system. J Biomater sci Polym Ed. 1995;7(3):289-96

Hirose S, Tsurui H, Nishimura H, Juang Y, Shirai T.
Mapping of a gene for hypergammaglobulinemia to the distal region on chormosome $ in NZB mice and its contribution to systemic lupus erythematosus in (NZB x NZW)F1 mice.
Int Immunol. 1994;6(12):1857-64

Watanabe Y, Tsurui H, Ueda T, Furushima R, Takamiya S, Kita K, Nishikawa K, Watanabe K. Primary and higer order structure of nematode (Ascaris suum) mitochondrial tRNAs lacking either the T or D stem.
J Biol Chem 1994;221(1):166-72

Tsurui H, Kumazawa Y, Sanokawa R, Watanabe Y, Kuroda T, Wada A, Watanabe K, Shirai T.
Batchwise purification of specific tRNAs by a solid-phase DNA probe. Anal Biochem. 1994;221(1):166-72

Shiota J, Nishimura H, Okamoto H, Yu B, Hattori S, Abe M, Okada T, Nozawa S, Tsurui H, Hirose S, Shirai T
A unique murine CD43 epitope Lp-3: distinct distribution from another CD43 epitope S7. Cell Immunol. 1994;155(2):402-13

Hirose S, Wakiya M, Kawano-Nishi Y, Yi J, Sanokawa R, Taki S, Shimamura T, Kishimoto T, Tsurui H, Nishimura H, et al.
Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus.
Eur J Immunol. 1993;23(11):2813-20

Hara H, Yamaguchi T, Tahara H, Tsuyama N, Tsurui H, Ide T, Oda K. DNA-DNA subtractive cDNA cloning using oligo(dT)30-latex and PCR: identification of cellular genes which are overexpressed in senescent human diploid fibroblasts.
Anal Biochem. 1993:214(1):58-64

Nakamura T, NakajimaT, Tsunoda S, Nakada S, Oda K, Tsurui H, Wada A. Induction of E1A-responsive negative factor for transcription of the fiboronectin gene in adenovirus E1-transformed rat cells. J Virol. 1992; 66(11):6436-50

Nishimura H, Hattori S, Abe M, Ueda G, Okamoto H, Tsurui H, Hirose S, Shirai T.
Differential expression of three CD45 alternative structures on murin T cells:exon 6-dependent epitope as a marker for functional heterogeniety of CD4+ T cells.
Int Immunol. 1992;4(8):923-30

Kumazawa Y, Yokogawa T, Tsurui H, Miura K, Watanabe K.
Effect of higher-order structure of tRNAs on the stability of hybrids with oligodeoxyribonucleotides: separation of tRNA by an efficient solution hybridization. Nucleic Acids Res. 1992;20(9):2223-32

Tsurui H, Kim N, Umezawa Y, Kato S. Efficient cDNA cloning method using solid phase DNA probe.
Nucleic Acids Symp Ser. 1992;(27):155-6

Hara E, Tsurui H, Shinozaki A, Nakada, S, Oda K.
Cooperative effect of antisense-Rb and antisense-p53 oligoners on the extraction of life span in human diploid fibroblasts, TIG-1. Biochem Biophys Res Commun. 1991;179(1):528-34

Tsurui H, Kishimoto T, Sanokawa R, Shirai T.
Precise discrimination among homologous sequences by DNA probe column chromatography. Nucleic Acids Symp Ser. 1991;(25):39-40

Tsurui H, Kumazawa Y, Sanokawa R, Watanabe K. Wada A, Shirai T. Sequence specific purification of a particular tRNA by solid-phase DNA probe.
Nucleic Acids Symp Ser. 1991;(25):149-50

Tsurui H, Hara E, Oda K, Suyama A, Nakada S, Wada A.
A rapid and efficient cloining method with a solid-phase DNA probe: application for cloning the 5'-flanking region of the gene encoding human fibronectin.
Gene. 1990;88(2):233-9

Hara E, Kato T, Nakada S, Nakajima T, Tsurui H, Oda K.
Construction of a subtracted cDNA library using oligo(dT)-latex. Nucleic Acid Symp Ser. 1990;(22):29-30

Tsurui H, Suyama A, Wada A. Temperature gradient DNA-probe column chromatography: as tools for detection and purification of particular DNAs and RNAs.
Nucleic Acids Symp Ser. 1988;(19):49-52

Okada A, Nakanishi M, Tsurui H, Wada A, Terashima M, Osawa T. A hapten-induced conformational change accompanies the cryoprecipitation of an immunoglobulin.
Mol Immunol. 1985; 22(6):715-8

Review

(1) Tsurui H and Takahashi T. Prediction of T-cell epitope. J Pharmacol Sci. 2007; 105:299-316

著書
(1)Tsurui H and Takahashi T. Practical estimation of TCR-pMHC binding free-energy based on dielectric model and coarse-grained model. In Molecular Dynamics / Book2, InTech, in press.

(2)鶴井　博理、佐野川　玲子、岸本　利彦
「アフィニティーカラムによる核酸の分離精製」
新生化学実験講座２　核酸Ⅰ　第９章　日本生化学会編　東京化学同人　１９９１年
169-192

(3)鶴井　博理、西村　裕之
「遺伝子診断：新しい素材の応用の可能性」
バイオコンジュゲート医薬品　第7章　稲田　祐二、谷本　剛編　廣川書店　１９９３年
147-169

(4)Wada A, Tsurui H, Suyama A.
High Base-sequence-resolution extraction of DNA fragments by immobilized probe for high-efficiency gene cloning.
Chap. 9 in Advanced techniques in chromosome research, ed. Adolf KW, Marcel Dekker Inc. 1991

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鶴井 博理（ツルイ ヒロミチ）

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