教室紹介、スタッフ紹介、研究、業績等、順天堂大学大学院 分子病理病態学(病理・腫瘍学講座)に関する様々な情報をご案内します。

大学院医学研究科各研究分野紹介一覧分子病理病態学(病理・腫瘍学講座) 各研究分野紹介一覧へ




  1. Hamano Y, Ito F, Suzuki O, Koura M, Matsuoka S, Kobayashi T, Sugitani Y, Wali N, Koyanagi A, Hino O, Suzuki S, Sugamata R, Yoshizawa H, Yumura W, Maruyama N, Kameoka Y, Noda Y, Hasegawa Y, Arai T, Suzuki K. Vasculitis and crescentic glomerulonephritis in a newly established congenic mouse strain derived from ANCA-associated vasculitis-prone SCG/Kj mice. Autoimmunity, in press.
  2. Mizukoshi K, Okazawa Y, Haeno H, Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state. International Journal of Cancer, in press.
  3. Huang Y, Lu H, Ren X, Li F, Bu W, Liu W, Daily WP, Saeki H, Gabrielson K, Abraham R, Eckenhoff R, Gao WD. Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy. Cardiovasc Res, in press.
  4. Saeki H, Hlaing MT, Horimoto Y, Kajino K, Ohtsuji N, Fujino K, Terao Y, Hino O. Usefulness of immunohistochemistry for mismatch repair protein and microsatellite instability examination in adenocarcinoma and background endometrium of sporadic endometrial cancer cases. J Obstet Gynaecol Res, in press.
  5. Horimoto Y, Terao T, Tsutsumi Y, Tanabe M, Mogushi K, Hlaing MT, Sasaki R, Saeki H, Okazaki M, Sonoue H, Arakawa A, Saito M. Estrogen receptor-positive ductal carcinoma in situ frequently overexpresses HER2 protein without gene amplification. Am J Surg Pathol 43:1221-1228 (2019)
  6. Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Polanska UM, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K., Hamada M, Orimo A. Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity. Life Sci Alliance, 2: pii:e201900425, doi:10.26508/lsa.201900425 (2019)
  7. Toriyama A, Izumi H, Tomita S, Nagashima Y, Ueda Y, Aoki Y, Tsujimura A, Yao T, Hino O. Renal medullary carcinoma in a young mixed-race man in Japan. Pathol Int 69:241-245 (2019)
  8. Yoshida GJ, Azuma A, Miura Y, Orimo A. Activated fibroblast program orchestrates tumor initiation and progression; Molecular mechanisms and the associated therapeutic strategies. Int J Mol Sci, in press.
  9. Mezawa Y, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Morimoto C, Hino O, Orimo A. CD26 expression is attenuated by TGF-β and SDF-1 autocrine signaling on stromal myofibroblasts in human breast cancers. Cancer Med, in press.
  10. Feng J, Li T, Yee R, Yuan Y, Bai C, Cai M, Shi W, Embers M, Brayton C, Saeki H, Gabrielson K, Zhang Y. Stationary phase persister/biofilm microcolony of Borrelia burgdorferi causes more severe disease in a mouse model of Lyme arthritis: implications for understanding persistence, Post-treatment Lyme Disease Syndrome (PTLDS), and treatment failure. Discov Med 27:125-138 (2019)
  11. Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K. Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero. Mol Brain 12:3 (2019)
  1. Horimoto Y, Tanabe M, Kazuno S, Muira Y, Mogushi K, Sonoue H, Arakawa A, Kajino K, Kobayashi T, Saito M. Elucidation of inhibitory effects on metastatic sentinel lymph nodes of breast caner during One-Step Nucleic Acid Amplification. Sci Rep 8:7563 (2018)
  2. Ogasawara Y, Yamada S, Suzuki K, Obinata K, Hashizume A, Tomita S, Okazaki T. Laparoscopic treatment of a simple hepatic cyst using argon beam coagulation. J Ped Surg Case Rep 31:4-6 (2018)
  3. Suyama Y, Tanaka M, Fujii Y, Toriyama A, Houjou S. Adult female with fever and groin pain. J Emerg Med 54:e31-e32 (2018)
  4. He C, Fukumura Y, Toriyama A, Ogura K, Sasahara N, Mitani K, Yao T. Pyloric gland adenoma (PGA) of the gallbladder: A unique and distinct tumor from PGAs of the stomach, duodenum, and pancreas. Am J Surg Pathol 42:1237-1245 (2018)
  5. Komura M, Yagishita S, Nakamura K, Arano N, Takeshige T, Muraki K, Nagashima O, Izumi H, Tomita S, Sasaki S, Takahashi K. A case of a pregnant woman diagnosed as having ALK-rearranged lung adenocarcinoma. In Vivo 32:1205-1209 (2018)
  6. Okazawa Y, Mizukoshi K, Koyama Y, Okubo S, Komiyama H, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K, Orimo A. High-sensitivity detection of micrometastases in GFP-labelled colon tumor organoids extracted from patient-derived tumor xenografts. J Vis Exp (136):e57374 (2018)
  7. Roswall P, Bocci M, Bartoschek M, Li H, Kristiansen G, Jansson S, Lehn S, Sjolund J, Reid S, Larsson C, Eriksson P, Anderberg C, Cortez E, Saal LH, Orsmark-Pietras C, Cordero E, Haller BK, Hakkinen J, Burvenich I, Lim E, Orimo A, Hoglund M, Ryden L, Moch H, Scott AM, Eriksson U, Pietras K. Microenvironmental control of breast cancer subtype elicited by paracrine platelet derived growth factor-CC signaling. Nat Med 24:463-473 (2018)
  8. Omoto T, Kim-Kaneyama J, Lei X., Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo S, Haraguchi S, Miyazaki T, Miyazaki A. The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. Oncogene 37:1205-1219 (2018)
  9. Okazaki M, Horimoto Y, Tanabe M, Ichikawa Y, Tokuda E, Arakawa A, Kobayashi T, Saito M. Predictive markers for efficacy of everolimus plus exemestane in patients with luminal HER2-nagative metastatic breast cancer. Med Oncol 35:48 (2018)
  10. Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T. The relationship between TP53 gene status and carboxylesterase 2 expression in human colorectal cancer. Dis Markers 2018:5280736 (2018)
  1. Arano N, Morio Y, Futagawa T, Hashizume A, Nagashima O, Sasaki SI, Tominaga S, Takahashi K. Lung metastases from cutaneous adenoid cystic carcinoma 23 years after initial treatment. Respir Med Case Rep 21:121-123 (2017)
  2. Sekiguchi Y, Wakabayashi M, Takizawa H, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. A case of Waldenstrom Macroglobulinemia in which intermittent one-day administration cycles of bendamustine were effective for alleviation of nausea and maintenance of remission. J Clin Exp Hematop 57:79-81 (2017)
  3. Ikeda K, Nakajima S, Tanji K, Hirai T, Uomori K, Morimoto S, Tomita S, Fukunaga M, Tamura N, Sekigawa I. Intestinal perforation due to hemorrhagic cytomegalovirus enteritis in a patient with severe uncontrolled lupus nephritis: a case and review of the literature. Rheumatol Int 37:1395-1399 (2017)
  4. Sekiguchi Y, Takizawa H, Inano T, Fukuda Y, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. Three cases of relapsed/refractory multiple myeloma under hemodialysis treated with panobinostat/bortezomib/dexamethasone (FVD). Int J Hematol 106:581-587 (2017)
  5. Tsuzuki Y, Kikuchi I, Nojima M, Yoshida K, Hashizume A, Tomita S. A case report: ovarian Sertoli-Leydig cell tumor with hyperestrogenism and endometrial hyperplasia in a postmenopausal woman. Jpn Clin Med 8:1179066017695239 (2017)
  6. Nakaoka HJ, Tanei Z, Hara T, Weng JS, Kanamori A, Hayashi T, Sato H, Orimo A, Otsuji K, Tada K, Morikawa T, Sasaki T, Fukayama M, Seiki M, Murakami Y, Sakamoto T. Mint3-mediated L1CAM expression in fibroblasts promotes cancer cell proliferation via integrin α5β1 and tumour growth. Oncogenesis 6:e334 (2017)
  7. Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K., Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes. Respir Res 18:46 (2017)
  8. Kono H, Uchida S, Muso E, Endo T, Kakita H, Hamano Y. Demographic characteristics of Japanese participants in PEXIVAS as compared with REMIT-JAV. Rheumatology 56(supple 3):150 (2017)
  9. Ito-Ihara T, Furuta S, Komagata Y, Muso E, Endo T, Uchida S, Kono H, Hamano Y. Two international multiregional investigator initiated clinical trials on vasculitis: collaboration with EUVAS, VCRC, and Nationwide vasculitis study groups of Japan. Rheumatology 56(supple.3):149 (2017)
  10. Hamano Y, Suzuki K, Ito F. Epitopic specificity of MPO-ANCA in Japanese ANCA-associated vasculitis patients. Rheumatology 56(supple 3):126 (2017)
  11. Takigawa M, Masutomi H, Kishimoto Y, Shimazaki Y, Hamano Y, Kondo Y, Arai T, Lee J, Ishii T, Mori Y, Ishigami A. Time-dependent alterations of vancomycin-induced nephrotoxicity in mice. Biol Pharm Bull 40:975-983 (2017)
  12. Hino O, Kobayashi T. Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor gene, and the tuberous sclerosis complex. Cancer Sci 118:5-11 (2017) Review
  1. Mizutani N, Abe M, Matsuoka S, Kajino K, Wakiya M, Ohtsuji N, Hatano R, Morimoto C, Hino O. Establishment of anti-mesothelioma monoclonal antibodies. BMC Res Notes 9:324 (2016)
  2. Escudero-Esparza A., Bartoschek M., Gialeli C., Okroj M., Owen S., Jirstrom K., Orimo A., Jiang WG., Pietras K., Blom AM. Complement inhibitor CSMD1 acts as tumor suppressor in human breast cancer. Oncotarget 7:76920-76933 (2016)
  3. Mezawa Y, Orimo A. The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. Cell Tissue Res 365:675-689 (2016) Review
  4. Englund E, Bartoschek M, Reitsma B, Jacobsson L, Escudero-Esparza A, Orimo A, Leandersson K, Hagerling C, Aspberg A, Storm P, Okroj M, Mulder H, Jirstrom K, Pietras K, Blom AM. Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer. Oncogene 235:5585-5596 (2016)
  5. Matsuda Y, Hamayasu H, Seki A, Nonaka K, Wang T, Matsumoto T, Hamano Y, Sumikura H, Kumasaka T, Murayama S, Ishizu A, Shimizu A, Sugihara T, Arai T. Presence of citrullinated histone H3-positive neutrophils in microscopic polyangiitis from the early phase: An autopsy proven case. Pathol Int 66:466-471 (2016)
  6. Hoshika Y, Takahashi F, Togo S, Hashimoto M, Nara T, Kobayashi T, Nurwidya F, Kataoka H, Kurihara M, Kobayashi E, Ebana H, Kikkawa M, Ando K, Nishino K, Hino O, Takahashi K, Seyama K. Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dube syndrome. Physiol Rep 4:e13025 (2016)
  7. Aizawa Y, Shirai T, Kobayashi T, Hino O, Tsuji Y, Inoue H, Kazami M, Tadokoro T, Suzuki T, Kobayashi K, Yamamoto Y. Metabolic abnormalities induced by mitochondrial dysfunction in skeletal muscle of the renal carcinoma Eker (TSC2+/-) rat model. Biosci Biotech Biochem 80:1513-1519 (2016)
  8. Aizawa Y, Shirai T, Kobayashi T, Hino O, Tsuji Y, Inoue H, Kazami M, Tadokoro T, Suzuki T, Kobayashi KI, Yamamoto Y. The tuberous sclerosis complex model Eker (TSC2+/-) rat exhibits hyperglycemia and hyperketonemia due to decreased glycolysis in the liver. Arch Biochem Biophys 590:48-55 (2016)
  1. Morinaga H, Miyazaki T, Tsutsui M, Kasai T, Takagi A, Kajino K, Miyauchi K, Daida H. Ischemic cardiomyopathy with a rapid progression from thrombotic thrombocytopenic purpura. Intern Med 54:2351-2354 (2015)
  2. Sekiguchi Y, Ichikawa K, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. Bone formation following lenalidomide-dexamethasone combination therapy in cases of multiple myeloma refractory to high-dose chemotherapy with bortezomib and autologous peripheral blood stem cell transplantation: report of a case and review of the literature. Int J Clin Exp Pathol 8:9609-9619 (2015)
  3. Sekiguchi Y, Shirane S, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. Peripheral T cell lymphoma, not otherwise specified with myelofibrosis: report of a case with review of the literature. Int J Clin Exp Pathol 8:4186-4203 (2015)
  4. Sekiguchi Y, Shimada A, Ichikawa K, Wakabayashi M, Sugimoto K, Ikeda K, Sekikawa I, Tomita S, Izumi H, Nakamura N, Sawada T, Ohta Y, Komatsu N, Noguchi M. Epstein-Barr virus-positive multiple myeloma developing after immunosuppressant therapy for rheumatoid arthritis: a case report and review of literature. Int J Clin Exp Pathol 8:2090-2102 (2015)
  5. Hayashi S, Abe Y, Tomita S, Nakanishi Y, Miwa S, Nakajima T, Nomoto K, Tsuneyama K, Fujimori T, Imura J. Primary non-gestational pure choriocarcinoma arising in the ovary: A case report and literature review. Oncol Lett 9:2109-2111 (2015)
  6. Englund E, Reitsma B, King B, Escudero-Esparza A, Owen A, Orimo A, Okroj M, Anagnostaki L, Jiang W, Jirstrom K, Blom A. The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and CD8+ T cells is associated with better prognosis of breast cancer patients. BMC Cancer 19:737 (2015)
  7. Saeki H, Suzuki C, Yamasaki S, Hashizume A, Izumi H, Suzuki F, Ishi K, Nojima M, Hino O. Cotyledonoid dissecting leiomyoma of the uterus: report of two cases. Arch Gynecol Obstet 291:357-361 (2015)
  8. Izuta T, Kamiya K, Gotoh S, Sugitani Y, Suzuki M, Noda T, Minowa O, Ikeda K. Perinatal Gjb2 gene transfer rescues hearing in a mouse model of hereditary deafness. Hum Mol Genet 24:3651-3661 (2015)
  9. Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Kobayashi T, Hino O. Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway. Oncol Rep 34:2251-2258 (2015)
  10. Sugiura H, Yasuda S, Katsurabayashi, S, Kawano H, Endo K, Takasaki K, Iwasaki K, Ichikawa M, Kobayashi T, Hino O, Yamagata K. Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex. Nat Commun 6:6842 (2015)
  11. Ito Y, Kawano H, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Arai H, Kobayashi T, Hino O. Establishment of Tsc2-deficient rat embryonic stem cells. Int J Oncol 46:1944-1952 (2015)
  12. Hobbs RM, La HM, Makela JA, Kobayashi T, Noda T, Pandolfi PP. Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling. EMBO Rep 16:467-480 (2015)
  1. Naito R, Miyazaki T, Kajino K, Daida H. Fulminant pneumococcal infection. BMJ Case Rep Aug 22;2014 (2014)
  2. Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O. ERC/mesothelin is expressed in human gastric cancer tissues and cell lines. Oncol Rep 31:27-33 (2014)
  3. Kawamata F, Homma S, Kamachi H, Einama T, Kato Y, Tsuda M, Tanaka S, Maeda M, Kajino K, Hino O, Takahashi N, Kamiyama T, Nishihara H, Taketomi A, Todo S. C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma. J Gastroenterol 49:81-92 (2014)
  4. Toriyama A, Mori T, Sekine S, Yoshida A, Hino O, Tsuta K. Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural and lung tumours: a comparison with polyclonal PAX8 antibody. Histopathology 65:465-472 (2014)
  5. Kobayashi S, Fujimori T, Mitomi H, Tomita S, Ichikawa K, Imura J, Fujii S, Itabashi M, Kameoka S, Igarashi Y. Immunohistochemical assessment of a unique basal pattern of p53 expression in ulcerative-colitis-associated neoplasia using computer-assisted cytometry. Diagn Pathol 9:99 (2014)
  6. Ikumoto T, Hayashi S, Tomita S, Miwa S, Mitomi H, Fujimori T, Imura J. Manganese superoxide dismutase plays an important role in the inflammatory process and predicts disease severity and activity in patients with ulcerative colitis. APMIS 122:512-517 (2014)
  7. Saito N, Tomita S, Ichikawa K, Mitomi H, Imura J, Fujimori T. Analysis of KRAS mutations in cases of metastatic colorectal cancer at a single institution in Tochigi, Japan. Pathobiology 81:133-137 (2014)
  8. Okamoto Y, Fujimori T, Ohkura Y, Sugai T, Arai T, Watanabe G, Wada R, Ueno H, Togashi K, Yao T, Kushima R, Mitomi H, Tomita S, Igarashi Y, Ichikawa K. Histological assessment of intra- and inter-institutional reliabilities in detection of desmoplastic reaction in biopsy specimens of early colorectal carcinomas. Pathol Int 63:539-545 (2014)
  9. Akimoto N, Fujimori T, Mitomi H, Ichikawa K, Tomita S, Tatsuguchi A, Fujimori S, Naito Z, Sakamoto C.Micropapillary pattern at the invasive front and its association with unresectable colorectal carcinomas.Dis Markers 35:451-455, 2013. 62.Yamaguchi T, Ichikawa K, Sano Y, Sano W, Ikumoto T, Iwatate M, Tomita S, Kato H, Fujimori T. SSA/P with a minute T1 colorectal carcinoma. J Gastroenterol Hepatol 29:1 (2014)
  10. Orimo A. The biology of tumour metastasis, Lecture Note. Juntendo Med J 60:56-62 (2014) Review
  11. Tsutsumi S, Yasumoto Y, Saeki H, Ito M. Cranial dural cavernous angioma. Clin Neuroradiol. 24:155-159 (2014)
  12. Hamano Y, Abe M, Matsuoka S, Zhang D, Kondo Y, Kagami Y, Ishigami A, Maruyama N, Tsuruta Y, Yumura W, Suzuki K. Susceptibility quantitative trait loci for pathogenic leucocytosis in SCG/Kj mice, a spontaneously occurring crescentic glomerulonephritis and vasculitis model. Clin Exp Immunol 177:353-365 (2014)
  13. Suzuki K, Nagao T, Itabashi M, Hamano Y, Sugamata R, Yamazaki Y, Yumura W, Tsukita S, Wang PC, Nakayama T, Suzuki K. A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis. Nephrol Dial Transplant 29:1168-1177 (2014)
  14. Furuta S, Chaudhry AN, Hamano Y, Fujimoto S, Nagafuchi H, Makino H, Matsuo S, Ozaki S, Endo T, Muso E, Ito C, Kusano E, Yamagata M, Ikeda K, Kashiwakuma D, Iwamoto I, Westman K, Jayne D. Comparison of phenotype and outcome in microscopic polyangiitis between Europe and Japan. J Rheumatol 41:325-333 (2014)
  15. Kidokoro Y, Karasawa K, Minowa O, Sugitani Y, Noda T, Ikeda K, Kamiya K. Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness. PLoS One 9:e108216 (2014)
  16. Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K., Kurasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K. Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest 124:1598-1607 (2014)
  17. Shiono M, Kobayashi T, Takahashi R, Ueda M, Ishioka C, Hino O. Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality. Sci Rep 4:5927 (2014)
  18. Yasuda S, Sugiura H, Katsurabayashi S, Shimada T, Tanaka H, Takasaki K, Iwasaki K, Kobayashi T, Hino O, Yamagata K. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex. Sci Rep 4:5155 (2014)
  1. Ito M, Kajino K, Abe M, Fujimura T, Mineki R, Ikegami T, Ishikawa T, Hino O. NP-1250, an ABCG inhibitor, induces apoptotic cell death in mitoxantrone-resistant breast carcinoma MCF7 cells via a caspase-independent pathway. Oncol Rep 29:1492-1500 (2013)
  2. Obulhasim G, Yasen M, Kajino K, Mogushi K, Tanaka S, Mizushima H, Tanaka H, Arii S, Hino O. Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with metabolic syndrome. Hepatol Int 7:215-225 (2013)
  3. Okamoto K, Fujimori T, Yamaguchi T, Ichikawa K, Tomita S, Sugai T, Imura J, Ohkura Y, Yao T, Fujii S, Kusaka T, Sekikawa A, Fukui H, Chiba T, Kato H, Mitomi H. Overexpression of regenerating gene Iα appears to reflect aberration of crypt cell compartmentalization in sessile serrated adenoma/polyps of the colon. Diagn Pathol 8:187 (2013)
  4. Ichikawa K, Fujimori T, Moriya T, Ochiai A, Yoshinaga S, Kushima R, Nagahama R, Ohkura Y, Tanaka S, Ajioka Y, Hirata I, Tanaka M, Hoshihara Y, Kinoshita Y, Sasano H, Iwashita A, Tomita S, Hirota S, Yao T, Fujii S, Matsuda T, Ueno H, Ishikawa Y, Takubo K, Fukushima N, Sugai T, Iwafuchi M, Imura J, Manabe T, Fukayama M. Digestive disease management in Japan: a report on the 6th diagnostic pathology summer fest in 2012. Digestion 88:153-160 (2013)
  5. Shigaki K, Mitomi H, Fujimori T, Ichikawa K, Tomita S, Imura J, Fujii S, Itabashi M, Kameoka S, Sahara R, Takenoshita S. Immunohistochemical analysis of chromogranin A and p53 expressions in ulcerative colitis-associated neoplasia: neuroendocrine differentiation as an early event in the colitis-neoplasia sequence. Hum Pathol 44:2393-2399 (2013)
  6. Ohno K, Fujimori T, Okamoto Y, Ichikawa K, Yamaguchi T, Imura J, Tomita S, Mitomi H. Diagnosis of desmoplastic reaction by immunohistochemical analysis, in biopsy specimens of early colorectal carcinomas, is efficacious in estimating the depth of invasion.Int J Mol Sci 14:13129-13136 (2013)
  7. Yamaguchi T, Fujimori T, Tomita S, Ichikawa K, Mitomi H, Ohno K, Shida Y, Kato H. Clinical validation of the gastrointestinal NET grading system: Ki67 index criteria of the WHO 2010 classification is appropriate to predict metastasis or recurrence. Diagn Pathol 8:65 (2013)
  8. Masuda A, Kamai T, Mizuno T, Kambara T, Abe H, Tomita S, Fukabori Y, Yamanishi T, Kaji Y, Yoshida KI. Renal metanephric adenoma mimicking papillary renal cell carcinoma on computed tomography: A case report. Urol Int 90:369-372 (2013)
  9. Otake Y, Fujimori T, Akimoto N, Ikematsu H, Okamoto Y, Yamaguchi T, Ichikawa K, Tomita S, Saito Y. Validation of pyrosequencing for analysis of KRAS mutation in colorectal cancer. Dokkyo J Med Sci 40:55-59 (2013)
  10. Maruoka T, Tomita S, Ichikawa K, Kojima M, Hakata Y, Imai Y, Imura J, Fujimori T, IgG4-positive plasmocytosis of inflammatory cell spreading pattern revealed to differentiation in classic oral lichen planus. Dokkyo J Med Sci 40:17-25 (2013)
  11. Ueda H, Tanaka H, Ichikawa K, Itabashi M, Kameoka S, Fujii S, Saito N, Kimura R, Shida Y, Fujimori Y, Ohtake S, Tomita S, Imura J, Yasuda Y, Tanigawa N, Uchiyama K, Fujimori T. Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions. Surg Today 43:1275-1280 (2013)
  12. Katake Y, Ichikawa K, Fujio C, Tomita S, Imura J, Fujimori T. Irregular arrangement of collecting venules (IRAC) provides a critical endoscopic insight in Helicobacter pylori-induced gastritis: A secondary publication. Biomed Rep 1:23-27 (2013)
  13. Tanaka T, Ichikawa K, Maruoka T, Tomita S, Ueda H, Yamaguchi T, Shida Y, Kato H, Nagata H, Kubota K, Akimoto N, Sakamoto C, Imura J, Arita M, Tanaka H, Okamoto Y, Igarashi Y, Fujimori T. Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab. Mol Clin Oncol 2:291-296 (2013)
  14. Shida Y, Ichikawa H, Fujimori T, Fujimori Y, Tomita S, Fujii T, Sano Y, Oda Y, Goto H, Ohta A, Tanaka S, Sugai T, Yao T, Ohkura Y, Imura J, Kato H. Differentiation between sessile serrated adenoma/polyp and non-sessile serrated adenoma/polyp in large hyper plastic polyp: A Japanese collaborative study. Mol Clin Oncol 1:53-58 (2013)
  15. Polanska Y, Orimo A. Carcinoma Associated Fibroblasts. J Cell Physiol 228:1651-1657 (2013) Review
  16. Togo S, Polanska Y, Horimoto Y, Orimo A Carcinoma-associated fibroblasts (CAFs) are a promising therapeutic target. Cancers 5:149-169 (2013) Review
  17. Nishioka K, Tanaka R, Tsutsumi S, Shimura H, Oji Y, Saeki H, Yasumoto Y, Ito M, Hattori N, Urabe T. Longitudinally extensive transverse myelitis with intramedullary metastasis of small-cell lung carcinoma: an autopsy case report. Case Rep Neurol Med 2018:305670 (2013)
  18. Hamano Y, Yumura W, Maruyama N, Suzuki K. Pathogenic leukocytosis and their susceptibility QTLs for vasculitis and crescentic glomerulonephritis in a model of SCG/Kj mice. Presse Med Quart Med Rev 42:687 (2013) Review
  19. Yumoto T, Nakadate K, Nakamura Y, Sugitani Y, Sugitani-Yoshida R, Ueda S, Sakakibara S. Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors. PLoS One 8:e79895 (2013)
  20. Massa F, Garbay S,Bouvier R, Sugitani Y, Noda T, Gubler MC, Heidet L, Pontoglio M, Fischer E. Hepatocyte nuclear factor 1b controls nephron tubular development. Development 140:886-896 (2013)
  21. Okura H, Kobayashi T, Koike M, Ohsawa M, Zhang D, Arai H, Uchiyama Y, Hino O. Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through mTORC1 signaling pathway. Int J Oncol 43:447-456 (2013)
  22. Kawai A, Kobayashi T, Hino O. Folliculin regulates cyclin D1 expression through cis-acting elements in the 3’ untranslated region of cyclin D1 mRNA. Int J Oncol 42:1597-1604 (2013)
  23. Ohsawa M, Kobayashi T, Okura H, Igarashi T, Mizuguchi M, Hino O. TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity. PLoS One 8:e54503 (2013)
  1. Yasen M, Obulhasim G, Kajino K, Mogushi K, Mizushima H, Tanaka S, Tanaka H, Hino O, Arii S. DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue. Int J Oncol 40:789-97 (2012)
  2. Okumura A, Lee T, Ikeno M, Shimojima K, Kajino K, Inoue Y, Yoshikawa N, Suganuma H, Suzuki M, Hisata K, Shoji H, Takanashi JI, Barkovich AJ, Shimizu T, Yamamoto T, Hayashi M. A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastoma. Brain Dev 34:881-885 (2012)
  3. Imura J, Uchida Y, Nomoto K, Ichikawa K, Tomita S, Iijima T, Fujimori T. Laminin-5 is a biomarker of invasiveness in cervical adenocarcinoma. Diagn Pathol 7:105 (2012)
  4. Shida Y, Fujimori T, Tanaka H, Fujimori Y, Kimura R, Ueda H, Ichikawa K, Tomita S, Nagata H, Kubota K, Tsubaki M, Kato H, Yao T, Sugai T, Sugihara K, Ohkura Y, Imura J. Clinicopathological features of serrated adenocarcinoma defined by Makinen in dukes' B colorectal carcinoma. Pathobiology 79:169-174 (2012)
  5. Khan H, Orimo A. TGF-β: guardian of catabolic metabolism in carcinoma-associated fibroblats (CAFs), Invited News and Views. Cell Cycle 11:4-5 (2012)
  6. Horimoto, Y, Takahashi T, Polanska Y, Orimo A. Emerging roles of the tumour-associated stroma in promoting tumour metastasis., Cell Adh Migr 6:193-202 (2012) Review
  7. Saeki H, Hashizume A, Izumi H, Suzuki F, Ishi K, Nojima M, Maeda M, Hino O. The utility of serum N-ERC/mesothelin as biomarker of ovarian carcinoma. Oncol Lett 4: 637-641 (2012)
  8. Hamano Y, Yoshizawa H, Sugase T, Miki T, Ohtani N, Hanawa S, Takeshima E, Morishita Y, Saito O, Takemoto F, Muto S, Yumura W, Kusano, E. Rituximab treatment for PR3-ANCA-positive membranoproliferative glomerulonephritis associated with adult-onset periodic fever syndrome. Case Rep Nephrol Urol 2:92-101 (2012)
  9. Takeda S, Chinda J, Murakami T, Numata A, Iwazu Y, Akimoto T, Hamano Y, Muto S, Takahashi M, Kusano E. Development of features of glomerulopathy in tumor-bearing rats: a potential model for paraneoplastic glomerulopathy. Nephrol Dial Transplant 27:1786-1792 (2012)
  10. Sato A, Kasai S, Kobayashi T, Takamatsu Y, Hino O, Ikeda K, Mizuguchi M. Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex. Nat Commun 3:1292 (2012)
  1. Yamagishi H, Fukui H, Tomita S, Ichikawa K, Imura J, Ishizuka M, Kubota K, Fujimori T. Ectopic gastric mucosa and pancreatic ducts in the rectum. Intern Med 50:1587-1589 (2011)
  2. Tanaka H, Fukui H, Fujii S, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Yasuda Y, Chiba T, Fujimori T. Immunohistochemical analysis of REG Iα expression in ulcerative colitis-associated neoplastic lesions. Digestion 83:204-209 (2011)
  3. Polanska U., Ahmet A, Orimo A. Experimental generation of carcinoma-associated fibroblasts (CAFs) from human mammary fibroblasts. J Vis Exp (56):e3201 (2011)
  4. Numata A, Akimoto T, Toshima M, Iwazu Y, Otani N, Miki T, Sugase T, Saito O, Hamano Y, Takemoto F, Ueda Y, Muto S, Kusano E. Membranous nephropathy in an HIV-positive patient complicated with hepatitis B virus infection. Clin Exp Nephrol 15:769-773 (2011)
  5. Hanawa S, Akimoto T, Uehara E, Inoue M, Imai T, Kotoda A, Yoshizawa H, Matsuyama T, Ueda M, Saito O, Hamano Y, Yumura W, Ozawa K, Muto S, Kusano E. Renal failure caused by plasma cell infiltration in multiple myeloma. Clin Exp Nephrol 15:586-590 (2011)
  6. Zhang D, Kobayashi T, Kojima T, Kanenishi K, Hagiwara Y, Abe M, Okura H, Hamano Y, Sun G, Maeda M, Jishage K, Noda T, Hino O. Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice. Cancer Sci 102:720-727 (2011)
  1. Hanzawa K, Momose S, Higashi M, Tokuhira M, Watanabe R, Kajino K, Hino O, Itoyama S, Kizaki M, Tamaru J. Y-box binding protein-1 expression in diffuse large B cell lymphoma: an impact on prognosis in the rituximab era. Leuk Lymphoma 51:1-9 (2010)
  2. Tan K, Kajino K, Momose S, Masaoka A, Sasahara K, Shiomi K, Izumi H, Abe M, Ohtsuji N, Wang T, Hino O, Fujii H. Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. Hum Pathol 41:1330-1338 (2010)
  3. Wang T, Kajino K, Abe M, Tan K, Maruo M, Sun G, Hagiwara Y, Maeda M, Hino O. Suppression of cell death by the secretory form of N-terminal ERC/mesothelin. Int J Mol Med 26: 185-91 (2010)
  4. Hakata Y, Fukui H, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Kawamata H, Imai Y, Fujimori T. Expression of beta-catenin and REG Ia, in relation to cell proliferative ability in salivary gland tumors. Exp Ther Med 1: 437-443 (2010)
  5. Ogata H, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Imura J, Ito Y, Fujita M, Tsubaki M, Kato H, Fujimori T, Fukui H. GROα promotes invasion of colorectal cancer cells. Oncol Rep 24:1479-1486 (2010)
  6. Hirose M, Fukui H, Igarashi Y, Fujimori Y, Katake Y, Sekikawa A, Ichikawa K, Tomita S, Imura J, Ajioka Y, Ueno H, Hase K, Ohkura Y, Kashida H, Togashi K, Nishigami T, Matsui T, Yao T, Wada R, Matsuda K, Watanabe T, Ochiai A, Sugai T, Sugihara K, Fujimori T. Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a Japanese collaborative study. J Gastroenterol 45:1212-1218 (2010)
  7. Sekikawa A, Fukui H, Suzuki K, Karibe T, Fujii S, Ichikawa K, Tomita S, Imura J, Shiratori K, Chiba T, Fujimori T: Involvement of the IL-22/REG Ialpha axis in ulcerative colitis. Lab Invest 90:496-505 (2010)
  8. Kojima Y, Acar A, Eaton E, Mellody K, Scheel C, Ben-Porath I, Onder T, Wang CZ, Richardson A, Weinberg RA, Orimo A. Autocrine TGF-b and SDF-1 signaling drives evolution of mammary stromal fibroblasts into tumor-promoting myofibroblasts. Proc Natl Acad Sci USA 107:20009-20014 (2010)
  9. Shimoda M, Mellody K, Orimo A. Carcinoma-associated fibroblasts are a rate-limiting determinant for tumor progression. Semin Cell Dev Biol 21:19-25 (2010) Review
  10. Hamano E, Tsutsumi S, Nonaka Y, Abe Y, Yasumoto Y, Saeki H, Ito M. Huge supratentorial extraventricular anaplastic ependymoma presenting with massive calcification--case report. Neurol Med Chir 50:150-153 (2010)
  11. Kunogi M, Kurihara M, Ikegami TS, Kobayashi T, Shindo N, Kumasaka T, Gunji Y, Kikkawa M, Iwakami S, Hino O, Takahashi K, Seyama K. Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature. J Med Genet 47:281-287 (2010)
  12. Kokubo T, Kakinuma S, Kobayashi T, Watanabe F, Iritani R, Tateno K, Nishimura M, Nishikawa T, Hino O, Shimada Y. Age dependence of radiation-induced renal cell carcinomas in an Eker rat model. Cancer Sci 101:616-623 (2010)
  13. Inoue H, Uyama T, Suzuki T, Kazami M, Hino O, Kobayashi T, Kobayashi K, Tadokoro T, Yamamoto Y. Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization. Biochem Biophys Res Commun 391:1148-1153 (2010)
  14. Wang L, Kobayashi T, Piao X, Shiono M, Takagi Y, Mineki R, Taka H, Zhang D, Abe M, Sun G, Hagiwara Y, Okimoto K, Matsumoto I, Kouchi M, Hino O. Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product. FEBS Lett 584:39-43 (2010)
  1. Hayashi M, Tomita S, Fujimori T, Nagata H, Kubota K, Shoda A, Tada K, Kosaka N, Fukasawa I, Inaba N. Retrorectal epidermoid cyst with unusually elevated serum SCC level, initially diagnosed as an ovarian tumor. Rare Tumors 22:e21 (2009)
  2. Hayashi M, Tomita S, Fukasawa I, Inaba N. Large angioleiomyoma, rich of mast cell and sex hormone receptor _expression. Arch Gynecol Obstet 279:193-197 (2009)
  3. Yamagishi H, Fukui H, Sekikawa A, Kono T, Fujii S, Ichikawa K, Tomita S, Imura J, Hiraishi H, Chiba T, Fujimori T. Expression profile of REG family proteins REG I alpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers. Mod Pathol 22:906-913 (2009)
  4. Kimura T, Fukui H, Sekikawa A, Yamagishi H, Ichikawa K, Tomita S, Fujii S, Imura J, Kawamata H, Chiba T, Imai Y, Fujimori T. Involvement of REG Ialpha protein in the regeneration of ductal epithelial cells in the minor salivary glands of patients with Sjogren's syndrome. Clin Exp Immunol 155:16-20 (2009)
  5. Abe A, Fukui H, Fujii S, Kono T, Mukawa K, Yoshitake N, Sekikawa A, Ichikawa K, Tomita S, Yamagishi H, Imai Y, Shinoda M, Ishizaki H, Tanaka-Okamoto M, Kubota K, Miyoshi J, Takai Y, Fujimori T. Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate. J Pathol 217:42-53 (2009)
  6. Mutai H, Nagashima R, Sugitani Y, Noda T, Fujii M, Matsunaga T. Expression of POU3f3/Brn-1 and its genomic methylation in developing auditory epithelium. Dev Neurobiol 69:913-930 (2009)
  7. Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, Kasai M. The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev Biol 331:140-151 (2009)
  8. Piao X, Kobayashi T, Wang L, Shiono M, Takagi Y, Sun G, Abe M, Hagiwara Y, Zhang D, Okimoto K, Kouchi M, Matsumoto I, Hino O. Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway. Biochem Biophys Res Commun 389:16-21 (2009)
  1. Inami K, Kajino K, Abe M, Maruo M, Maeda M, Suyama M, Watanabe S, Hino O. Secretion of N-ERC/Mesothelin and expression of C-ERC/Mesothelin in human pancreatic ductal carcinoma. Oncol Rep 20:1375-1380 (2008)
  2. Shiono M, Kobayashi T, Takahashi R, Sun G, Abe M, Zhang D, Wang L, Piao X, Takagi Y, Mineki R, Taka H, Tada N, Sonobe S, Momose S, Ueda M, Hino O. The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition. Oncogene 27:6690-6697 (2008)
  3. Takagi Y, Kobayashi T, Shiono M, Wang L, Piao X, Sun G, Zhang D, Abe M, Hagiwara Y, Takahashi K, Hino O. Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein. Oncogene 27:5339-5347 (2008)
  4. Imamura O, Okada H, Takashima Y, Zhang D, Kobayashi T, Hino O. siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model. Cancer Lett 268:278-285 (2008)
  5. Shigeyama Y, Kobayashi T, Kido Y, Hashimoto N, Asahara S, Matsuda T, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Uchida T, Inoue M, Hino O, Kasuga M, Noda T. Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol Cell Biol 28:2971-2979 (2008)
  6. Suzuki T, Das SK, Inoue H, Kazami M, Hino O, Kobayashi T, Yeung RS, Kobayashi K, Tadokoro T, Yamamoto Y. Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation. Biochem Biophys Res Commun 368:132-137 (2008)
  1. Nakaishi M, Kajino K, Ikesue M, Hagiwara Y, Kuwahara M, Mitani H, Horikoshi-Sakuraba Y, Segawa T, Kon S, Maeda M, Wang T, Abe M, Yokoyama M, Hino O. Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin. Cancer Sci 98:659-64 (2007)
  2. Orimo A, Weinberg RA. Heterogeneity of stromal fibroblasts in tumor,, Invited commentary. (2006) Identification of fibroblast heterogeneity in the tumor microenvironment, Cancer Biol Ther, 6:618-619 (2007)
  3. Minami K, Tambe Y, Watanabe R, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, Okabe H, Chano T, Inoue H. Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway. J Virol 81:11106-11111 (2007)
  4. Sun GD, Kobayashi T, Abe M, Tada N, Adachi H, Shiota A, Totsuka Y, Hino O. The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation. Biochem Biophys Res Commun 360:181-187 (2007)
  5. Momose S, Kobayashi T, Tada N, Itoyama S, Hino O. N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo. Biochem Biophys Res Commun 356:693-698 (2007)
  6. Watanabe R, Tambe Y, Inoue H, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, Okabe H, Chano T. GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress. Int J Mol Med 19: 475-483 (2007)
  1. Tobita H, Kajino K, Inami I, Kano S, Yasen M, Imamura O, Kinoshita Y, Hino O. Gene expression profile of dbpA (DNA Binding Protein A) transgenic mice. Int J Oncol 29:673-679 (2006)
  2. Matsumoto F, Fujii H, Abe M, Kajino K, Kobayashi T, Matsumoto T, Ikeda K, Hino O. A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis. Hum Pathol 37:1592-1600 (2006)
  3. Orimo A, Weinberg RA. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5:1602-1606 (2006) Review
  4. Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K. Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. J Immunol 176:3662-3673 (2006)
  5. Owada Y, Abdelwahab SA, Kitanaka N, Sakagami H, Takano H, Sugitani Y, Sugawara M, Kawashima H, Kiso Y, Mobarakeh JI, Yanai K, Kaneko K, Sasaki H, Kato H, Saino-Saito S, Matsumoto N, Akaike N, Noda T, Kondo H. Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene. Eur J Neurosci 24:175-187 (2006)
  6. Kumada K, Yao R, Kawaguchi T, Karasawa M, Hoshikawa Y, Ichikawa K, Sugitani Y, Imoto I, Inazawa J, Sugawara M, Yanagida M, Noda T. The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase. J Cell Biol 72:835-846 (2006)
  7. Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T. PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development 133:1389-1398 (2006)
  8. Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J. Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway. J Biol Chem 281:40242-40251 (2006)
  9. Chano T, Saji M, Inoue H, Minami K, Kobayashi T, Hino O, Okabe H. Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation. Int J Mol Med 18: 425-432 (2006)
  10. Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene. Oncogene 25:2885-2889 (2006)
  1. Yasen M, Kajino K, Kano S, Tobita H, Yamamoto J, Uchiumi T, Kon S, Maeda M, Obulhasim G, Arii S, Hino O. The up-regulation of Y box binding proteins (dbpA and YB-1) as prognostic markers of hepatocellular carcinoma. Clin Cancer Res 11:7354-7361 (2005)
  2. Orimo A, Gupta P, Sgroi D, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey V, Richardson A, Weinberg RA. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348 (2005)
  1. Arakawa Y, Kajino K, Kano S, Tobita H, Hayashi J, Yasen M, Moriyama M, Arakawa Y, Hino O. Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: implications in hepatocarcinogenesis. Biochem Biophys Res Commun 322:297-302 (2004)
  2. Adachi H, Majima S, Kon S, Kobayashi T, Kajino K, Mitani H, Hirayama Y, Shiina H, Igawa M, Hino O. Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis. Oncogene 23:3495-3500 (2004)
  3. Okimoto K, Kouchi M, Matsumoto I, Sakurai J, Kobayashi T, Hino O. Natural history of the Nihon rat model of BHD. Curr Mol Med 4:887-893 (2004) Review
  4. Kanenishi K, Ueno M, Momose S, Kuwabara H, Tanaka H, Sato C, Kobayashi T, Hino O, Sakamoto H, Hata T. Prepro-orexin mRNA expression in the rat brain is increased during pregnancy. Neurosci Lett 368:73-77 (2004)
  5. Okamoto T, Kobayashi T, Hino O. Cloning of the Cav 1.3 (alpha1D) L-type Ca2+ channel from mouse and its expression in the liver. Int J Mol Med 13:573-576 (2004)
  6. Okimoto K, Sakurai J, Kobayashi T, Mitani H, Hirayama Y, Nickerson ML, Warren MB, Zbar B, Schmidt LS, Hino O. A germ-line insertion in the Birt-Hogg-Dube (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Proc Natl Acad Sci U S A 101:2023-2027 (2004)
  1. Kajino K, Hino O. Knudson's two hits, both associated with the insertions of genetic mobile elements in a rat pituitary adenoma. Proc Jpn Acad 79B:108-113 (2003)
  2. Honda S, Kobayashi T, Kajino K, Urakami S, Igawa M, Hino O. Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene. Mol Carcinog 37:122-129 (2003)
  3. Nakamura K, Xiu Y, Ohtsuji M, Sugita G, Abe M, Ohtsuji N, Hamano Y, Jiang Y, Takahashi N, Shirai T, Nishimura H, Hirose S. Genetic dissection of anxiety in autoimmune disease. Hum Mol Genet 12:1079-1086 (2003)
  4. Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M, Hirose S, Shirai T. A monoclonal antibody to the alpha2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. J Exp Med 198:497-503 (2003)
  5. Nakai S, Sugitani Y, Sato H, Ito S, Miura Y, Ogawa M, Nishi M, Jishage K, Minowa O, Noda T. Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development 130:4751-4759 (2003)
  6. Kobayashi T, Adachi H, Mitani H, Hirayama Y, Hino O. Toward chemotherapy for Tsc2-mutant renal tumor. Proc Jpn Acad 79B:22-25 (2003)
  7. Hino O, Kobayashi T, Momose S, Kikuchi Y, Adachi H, Okimoto K. Renal carcinogenesis: genotype, phenotype and dramatype. Cancer Sci 94:142-147 (2003) Review
  8. Kajino K, Hino O. Similarity of the secondary structure with identical seven bases in the pregenomic/genomic regions required for the replication of hepatitis B virus and hepatitis C virus. Proc Jpn Acad 78B:12-14 (2002)
  9. Hino O, Kajino K, Umeda T, Arakawa Y. Understanding the hypercarcinogenic state in chronic hepatitis: a clue to the prevention of human hepatocellular carcinoma. J Gastroenterol 37:883-887 (2002) Review
  10. Hayashi J, Kajino K, Umeda T, Takano S, Arakawa Y, Kudo M, Hino O. Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis. Int J Oncol 21:847-850 (2002)
  11. Abe M, Kajino K, Akbar SM, Yamamura K, Onji M, Hino O. Loss of immunogenecity of liver dendritic cells from mouse with chronic hepatitis. Int J Mol Med 9:71-76 (2002)
  12. Xiu Y, Nakamura K, Abe M, Li N, Wen XS, Jiang Y, Zhang D, Tsurui H, Matsuoka S, Hamano Y, Fujii H, Ono M, Takai T, Shimokawa T, Ra C, Shirai T, Hirose S. Transcriptional regulation of Fcgr2b gene by polymorphic promoter region and its contribution to humoral immune responses. J Immunol 169:4340-4346 (2002)
  13. Miura-Shimura Y, Nakamura K, Ohtsuji M, Tomita H, Jiang Y, Abe M, Zhang D, Hamano Y, Tsuda H, Hashimoto H, Nishimura H, Taki S, Shirai T, Hirose S. C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis. J Immunol 169:1334-1339 (2002)
  14. Sugitani Y, Nakai S, Minowa O, Nishi M, Jishage K, Kawano H, Mori K, Ogawa M, Noda T. Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes & Dev 16:1760-1765 (2002)
  15. Yao R, Ito C, Natsume Y, Sugitani Y, Yamanaka H, Kuretake S, Yanagida K, Sato A, Toshimori K, Noda T. Lack of acrosome formation in mice lacking a Golgi protein, GOPC. Proc Natl Acad Sci USA 99:11211-11216 (2002)
  16. Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 156:1099-1111 (2002)
  17. Owada Y, Takano H, Yamanaka H, Kobayashi H, Sugitani Y, Tomioka Y, Suzuki I, Suzuki R, Terui T, Mizugaki M, Tagami H, Noda T, Kondo H. Altered water barrier function in epidermal-type fatty acid binding protein-deficient mice. J Invest Dermatol 118:430-435 (2002)
  18. Hasegawa S, Sato T, Akazawa H, Okada H, Maeno A, Ito M, Sugitani Y, Shibata H, Miyazaki Ji J, Katsuki M, Yamauchi Y, Yamamura Ki K, Katamine S, Noda T. Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene. Proc Natl Acad Sci USA 99:11211-11216 (2002)
  19. Momose S, Kobayashi T, Mitani H, Hirabayashi M, Ito K, Ueda M, Nabeshima Y, Hino O. Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system. Hum Mol Genet 11:2997-3006 (2002)
  20. Hino O, Kobayashi T, Mitani H. Prevention of hereditary carcinogenesis. Proc Jpn Acad 78B:30-33 (2002)
  21. Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS, Ru B, Pan D. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 4:699-704 (2002)
  22. Satake N, Miyagawa M, Sakurai J, Mitani H, Kobayashi T, Tamura H, Hino O. N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat. Cancer Lett 184:157-163 (2002)
  23. Okamoto T, Kajino K, Hino O. Hepatoprotective drugs for the treatment of virus-induced chronic hepatitis: from hypercarcinogenic state to hypocarcinogenic state. Jpn J Pharmacol 87:177-180 (2001)
  24. Kajino K, Yamamoto T, Hayashi J, Umeda T, Takahara T, Hino O. Recombination hot spot of hepatitis B virus genome binds to members of the HMG domain protein family and the Y box binding protein family; implication of these proteins in genomic instability. Intervirology 44:311-316 (2001)
  25. Orimo A, Tomioka Y, Shimizu Y, Sato M, Oigawa S, Kamata K, Nogi Y, Inoue S, Takahashi M, Hata T, and Muramatsu M. Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. Clin Cancer Res 7:3097-3105 (2001)
  26. Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, Kobayashi E, Noda T, Hino O. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A 98:8762-8767 (2001)
  27. Hino O, Majima S, Kobayashi T, Honda S, Momose S, Kikuchi Y, Mitani H. Multistep renal carcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model--genotype, phenotype and environment. Mutat Res 477:155-164 (2001) Review
  28. Hayashi J, Aoki H, Kajino K, Moriyama M, Arakawa Y, Hino O. Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha. Hepatology 32:958-961 (2000)
  29. Majima S, Kajino K, Fukuda T, Otsuka F, Hino O. A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach. Jpn J Cancer Res 91:869-874 (2000)
  30. Umeda T, Yamamoto T, Kajino K, Hino O. Beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice. Int J Oncol 16:1133-1136 (2000)
  31. Orimo A, Yamagishi T, Tominaga N, Yamauchi Y, Hishinuma T, Okada K, Suzuki M, Sato M, Nogi Y, Suzuki H, Inoue S, Yoshimura K, Shimizu Y, Muramatsu M. Molecular cloning of testis-abundant finger protein (tfp)/ring finger protein 23 (RNF23); a novel RBCC (RING-B box-coiled coil)-B30.2 protein on the class I region of the human MHC. Biochem Biophys Res Commun 276:45-51 (2000)
  32. Orimo A, Tominaga N, Yoshimura K, Yamauchi Y, Nomura M, Sato M, Nogi Y, Suzuki M, Suzuki H, Ikeda K, Inoue S, Muramatsu M. Molecular cloning of ring finger protein 21 (RNF21)/ interferon-responsive finger protein (ifp1) which possesses two RBCC (RING-B box-coiled coil) domains in tandem. Genomics 69:143-149 (2000)
  33. Ogawa S, Saito T, Matsuda Y, Seki N, Hayashi A, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Hori T, Inoue S. Chromosome mapping of RNF16 and Rnf16, human, mouse and rat genes coding for testis RING finger protein (terf), a member of the RING finger family. Cytogenet Cell Genet 89:56-58 (2000)
  34. Ogawa S, Fujita M, Ishii Y, Tsurukami H, Hirabayashi M, Ikeda K, Orimo A, Hosoi T, Ueda M, Nakamura T, Ouchi Y, Muramatsu M, Inoue S. Impaired estrogen sensitivity in bone by inhibiting both estrogen receptor (ER) alpha and beta pathways. J Biol Chem 275:21372-21379 (2000)
  35. Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S. Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett 472:9-13 (2000)
  36. Jiang Y, Hirose S, Abe M, Sanokawa-Akakura R, Ohtsuji M, Mi X, Li N, Xiu Y, Zhang D, Shirai J, Hamano Y, Fujii H, Shirai T. Polymorphisms in IgG Fc receptor IIB regulatory regions associated with autoimmune susceptibility. Immunogenetics 51:429-435 (2000)
  37. Fujii H, Yoshida M, Gong ZX, Matsumoto T, Hamano Y, Fukunaga M, Hruban RH, Gabrielson E, Shirai T. Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity. Cancer Res 60:114-120 (2000)
  38. Fukuda T, Tani Y, Kobayashi T, Hirayama Y, Hino O. A new Western blotting method using polymer immunocomplexes: detection of Tsc1 and Tsc2 expression in various cultured cell lines. Anal Biochem 285:274-276 (2000)
  39. Fukuda T, Kobayashi T, Momose S, Yasui H, Hino O. Distribution of Tsc1 protein detected by immunohistochemistry in various normal rat tissues and the renal carcinomas of Eker rat: detection of limited colocalization with Tsc1 and Tsc2 gene products in vivo. Lab Invest 80:1347-1359 (2000)
  40. Kajino K, Hino O. TSC1 and TSC2 gene mutations in human kidney tumors. Contrib Nephrol 28:45-50 (1999)
  41. Fukuda T, Kido A, Kajino K, Tsutsumi M, Miyauchi Y, Tsujiuchi T, Konishi Y, Hino O. Cloning of differentially expressed genes in highly and low metastatic rat osteosarcomas by a modified cDNA-AFLP method. Biochem Biophys Res Commun 261:35-40 (1999)
  42. Akbar SM, Kajino K, Tanimoto K, Yamamura K, Onji M, Hino O. Unique features of dendritic cells in IFN-gamma transgenic mice: relevance to cancer development and therapeutic implications. Biochem Biophys Res Commun 259:294-299 (1999)
  43. Yamamoto T, Kajino K, Kudo M, Sasaki Y, Arakawa Y, Hino O. Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA. Hepatology 29:1446-1452 (1999)
  44. Kyo S, Takakura M, Kanaya T, Zhuo W, Fujimoto K, Nishio Y, Orimo A, Inoue M. Estrogen activates telomerase. Cancer Res 59:5917-5921 (1999)
  45. Orimo A, Inoue S, Minowa O, Tominaga N, Tomioka Y, Sato M, Kuno K, Hiroi,H, Shimizu Y, Suzuki M, Noda T, Muramatsu M. Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein (efp) gene, which is a direct target of estrogen receptor α (ERα). Proc Natl Acad Sci USA 96:12027-12032 (1999)
  46. Inoue S, Urano T, Ogawa S, Saito T, Orimo A, Hoshoi T, Ouchi, Y, Muramatsu M. Molecular cloning of rat efp: expression and regulation in primary osteoblasts. Biochem Biophys Res Commun 261:412-418 (1999)
  47. Orimo A, Tominaga N, Suzuki M, Kawakami T, Kuno J, Sato M, Minowa O, Inoue S, Kato S, Noda T, Muramatsu M. Successful germ-line transmission of chimeras generated by coculture aggregation with J1 ES cells and eight-cell embryos. Anal Biochem 269:204-207 (1999)
  48. Hiroi H, Inoue S, Watanabe T, Goto W, Orimo A, Momoeda M, Tsutsumi O, Taketani Y., Muramatsu M. Differential immunolocalization of estrogen receptor alpha and beta in rat ovary an uterus. J Mol Endocrinol 22:37-44 (1999)
  49. Watanabe T, Inoue S, Hiroi H, Orimo A, Muramatsu M., (1999) NMDA receptor type 2D gene as target for estrogen receptor in the brain. Brain Res Mol Brain Res 63:375-379 (1999)
  50. Shirai J, Ida A, Jiang Y, Sanokawa-Akakura R, Miura Y, Yan K, Hamano Y, Hirose S, Shirai T. Genetic polymorphism of murine tissue plasminogen activator associated with antiphospholipid syndrome. Genes Immun 1:130-136 (1999)
  51. Jiang Y, Hirose S, Sanokawa-Akakura R, Abe M, Mi X, Li N, Miura Y, Shirai J, Zhang D, Hamano Y, Shirai T. Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus. Int Immunol 11:1685-91 (1999)
  52. Minowa O, Ikeda K, Sugitani Y, Oshima T, Nakai S, Katori Y, Suzuki M, Furukawa M, Kawase T, Zheng Y, Ogura M, Asada Y, Watanabe K, Yamanaka H, Gotoh S, Nishi-Takeshima M, Sugitmoto T, Kikuchi T, Takasaka T, Noda T. Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science 285:1408-1411 (1999)
  53. Hino O, Fukuda T, Satake N, Kobayashi T, Honda S, Orimoto K, Yamashita Y, Kikuchi Y. TSC2 gene mutant (Eker) rat model of a Mendelian dominantly inherited cancer. Prog Exp Tumor Res 35:95-108 (1999) Review
  54. Fukuda T, Kobayashi T, Yasui H, Tsutsumi M, Konishi Y, Hino O. Distribution of Tsc2 protein in various normal rat tissues and renal tumours of Tsc2 mutant (Eker) rat detected by immunohistochemistry. Virchows Arch 434:341-350 (1999)
  55. Kobayashi T, Minowa O, Kuno J, Mitani H, Hino O, Noda T. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 59:1206-1211 (1999)
  56. Satake N, Kobayashi T, Kobayashi E, Izumi K, Hino O. Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas. Cancer Res 59:849-855 (1999)
  57. Yamamoto T, Kajino K, Ogawa M, Gotoh I, Matsuoka S, Suzuki K, Moriyama M, Okubo H, Kudo M, Arakawa Y, Hino O. Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration. Biochem Biophys Res Commun 251:339-343 (1998)
  58. Pugh JC, Guo JT, Aldrich C, Rall G, Kajino K, Tennant B, England JM, Mason WS. Aberrant expression of a cytokeratin in a subset of hepatocytes during chronic WHV infection. Virology 249:68-79 (1998)
  59. Orimo A, Inoue S, Ikeda K, Sato M, Kato A, Tominaga N, Suzuki M, Noda T, Watanabe M, Muramatsu M. Molecular cloning, localization and developmental expression of mouse brain finger protein (bfp); distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis Syndrome (SMS). Genomics 54:59-69 (1998)
  60. Watanabe T, Inoue S, Hiroi H, Orimo A, Kawashima H, Muramatsu M. Isolation of estrogen-responsive genes with a CpG island library. Mol Cell Biol 18:442-449 (1998)
  61. Okuda A, Fukushima A, Nishimoto M, Orimo A, Yamagishi, T, Nabeshima Y, Kuro-o M, Nabeshima Y, Boon K, Keaveney M, Stunnenberg HG, Muramatsu M. UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J 17:2019-2032 (1998)
  62. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, Muramatsu M. Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor of estrogen action in human. Nucleic Acids Res 26:3505-3512 (1998)
  63. Ogawa S, Inoue S, Watanabe T, Hiroi H, Orimo A, Hosoi T, Ouchi Y, Muramatsu M. The complete primary structure of human estrogen receptor β (ERβ) and its heterodimerization with ERα in vivo and in vitro. Biochem.Biophys.Res Commun 243:122-126 (1998)
  64. Ogawa S, Inoue S, Orimo A, Hosoi T, Ouchi Y, Muramatsu M. Cross inhibition of both estrogen receptor alpha and beta pathways by each dominant negative mutant. FEBS Lett 423:129-132 (1998)
  65. Ikeda K, Inoue S, Orimo A, Tsutsumi K, Muramatsu M. Promotor analysis of mouse estrogen-responsive finger protein (efp) gene: mouse efp promotor contains an E-box that is also conserved in human. Gene 216:155-162 (1998)
  66. Ogawa S, Goto W, Orimo A, Hosoi T, Ouchi Y, Muramatsu M, Inoue S. Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. Biochem Biophys Res Commun 251:515-519 (1998)
  67. Ida A, Hirose S, Hamano Y, Kodera S, Jiang Y, Abe M, Zhang D, Nishimura H, Shirai T. Multigenic control of lupus-associated antiphospholipid syndrome in a model of (NZW x BXSB) F1 mice. Eur J Immunol 28:2694-2703 (1998)
  68. Hamano Y, Hirose S, Ida A, Abe M, Zhang D, Kodera S, Jiang Y, Shirai J, Miura Y, Nishimura H, Shirai T. Susceptibility alleles for aberrant B-1 cell proliferation involved in spontaneously occurring B-cell chronic lymphocytic leukemia in a model of New Zealand White mice. Blood 92:3772-3779 (1998)
  69. Fujimura T, Hirose S, Jiang Y, Kodera S, Ohmuro H, Zhang D, Hamano Y, Ishida H, Furukawa S, Shirai T. Dissection of the effects of tumor necrosis factor-alpha and class II gene polymorphisms within the MHC on murine systemic lupus erythematosus (SLE). Int Immunol 10:1467-1472 (1998)
  70. Kajino K, Kamiya N, Yuasa S, Takahara T, Sakurai J, Yamamura K, Hino O. Evaluation of anti-hepatitis B virus (HBV) drugs using the HBV transgenic mouse: application of the semiquantitative polymerase chain reaction (PCR) for serum HBV DNA to monitor the drug efficacy. Biochem Biophys Res Commun 241:43-48 (1997)
  71. Akbar SM, Kajino K, Tanimoto K, Kurose K, Masumoto T, Michitaka K, Horiike N, Onji M. Placebo-controlled trial of vaccination with hepatitis B virus surface antigen in hepatitis B virus transgenic mice. J Hepatol 26:131-137 (1997)
  72. Kimura T, Arakawa Y, Inoue S, Fukushima Y, Kondo I, Koyama K, Hosoi T, Orimo A, Muramatsu M, Nakamura Y, Abe T, Inazawa J. The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-magenis syndrome region at 17p112., Am J Med Genet 69:320-324 (1997)
  73. Watanabe T, Inoue S, Ogawa S, Ishii Y, Hiroi H, Ikeda K, Orimo A, Muramatsu M. Agonistic effect of Tamoxifen is dependent on cell type, ERE-promoter context, and Estrogen receptor subtype: functional difference between estrogen receptor α and β. Biochem Biophys Res Commun 236:140-145 (1997)
  74. Ikeda K, Inoue S, Orimo A, Sano M, Watanabe T, Tsutsumi K, Muramatsu M. Multiple regulatory elements and binding proteins of the 5’-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem Biophys Res Commun 236:765-771 (1997)
  75. Inoue S, Orimo A, Saito T, Ikeda K, Sakata K, Hosoi T, Orimo H, Ouchi Y, Muramatsu M. A novel ring finger protein, BFP predominantly expressed in the brain. Biochem Biophys Res Commun 240:8-14 (1997)
  76. Ogawa S, Inoue S, Watanabe T, Hiroi H, Orimo A, Hosoi T, Ouchi Y, Muramastsu M. Molecular cloning and functional analysis of human estrogen receptor beta 2., J Bone Mineral Res 12:P255 (1997)
  77. Kodera S, Tomino Y, Hamano Y, Hirose S, Shirai T. Mapping of susceptibility genes for proliferative gromerulonephritis in BXSB mice. J Am Soc Nephrol 8(Suppl.):A2130 (1997)
  78. Jiang Y, Hirose S, Hamano Y, Kodera S, Tsurui H, Abe M, Terashima K, Ishikawa S, Shirai T. Mapping of a gene for the increased susceptibility of B1 cells to Mott cell formation in murine autoimmune disease. J Immunol 158:992-997 (1997)
  79. Hirose S, Yan K, Abe M, Jiang Y, Hamano Y, Tsurui H, Shirai T. Precursor B cells for autoantibody production in genomically Fas-intact autoimmune disease are not subject to Fas-mediated immune elimination. Proc Natl Acad Sci USA 94:9291-9295 (1997)
  80. Hirose S, Hamano Y, Shirai T. Genetic factors predisposing to B-CLL and to autoimmune disease in spontaneous murine model. Leukemia. 11(Suppl 3):267-70 (1997)
  81. Urakami S, Tsuchiya H, Orimoto K, Kobayashi T, Igawa M, Hino O. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Biochem Biophys Res Commun 241:24-30 (1997)
  82. Kobayashi T, Urakami S, Cheadle JP, Aspinwall R, Harris P, Sampson JR, Hino O. Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog. Mamm Genome 8:554-558 (1997)
  83. Kobayashi T, Mitani H, Takahashi R, Hirabayashi M, Ueda M, Tamura H, Hino O. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene. Proc Natl Acad Sci U S A 94:3990-3993 (1997)
  84. Kobayashi T, Urakami S, Hirayama Y, Yamamoto T, Nishizawa M, Takahara T, Kubo Y, Hino O. Intragenic Tsc2 somatic mutations as Knudson's second hit in spontaneous and chemically induced renal carcinomas in the Eker rat model. Jpn J Cancer Res 88:254-261 (1997)
  85. Aoki H, Kajino K, Arakawa Y, Hino O. Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal. Proc Natl Acad Sci USA 93:7300-7304 (1996)
  86. Aoki H, Yamamoto T, Kajino K, Arakawa Y, Hino O. Molecular diagnosis of hepatitis C viral infection. Intervirology 39:140-144 (1996) Review
  87. Matsuda Y, Inoue S, Seki N, Hosoi T, Orimo A, Muramatsu M, Hori T. Chromosome mapping of human (ZNF197), mouse and rat genes for brain finger protein (bfp), a member of the RING finger family. Genomics 33:325-327 (1996)
  88. Akisita M, Ouchi Y, Miyoshi H, Orimo A, Kozaki K, Eto M, Ishikawa M, Kim S, Toba K, Orimo H. Estrogen inhibits endothelin-1 production and c-fos gene expression in rat aorta. Atherosclerosis 125:27-38 (1996)
  89. Takeshima H, Ikemoto T, Nishi M, Nishiyama N, Shimuta M, Sugitani Y, Kuno J, Saito I, Saito H, Endo M, Iino M, Noda T. Generation and characterization of mutant mice lacking ryanodine receptor type 3. J Biol Chem 271:19649-19652 (1996)
  90. Orimoto K, Tsuchiya H, Kobayashi T, Matsuda T, Hino O. Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells. Biochem Biophys Res Commun 219:70-75 (1996)
  91. Tsuchiya H, Orimoto K, Kobayashi T, Hino O. Presence of potent transcriptional activation domains in the predisposing tuberous sclerosis (Tsc2) gene product of the Eker rat model. Cancer Res 56:429-433 (1996)
  92. Kajino K, Aoki H, Hino O. Genomic instability involved in virus-related hepatocarcinogenesis. Intervirology 38:170-172 (1995)
  93. Hino O, Kobayashi E, Nishizawa M, Kubo Y, Kobayashi T, Hirayama Y, Takai S, Kikuchi Y, Tsuchiya H, Orimoto K, Kajino K, Takahara T, Mitani H. Renal carcinogenesis in the Eker rat. J Cancer Res Clin Oncol 121:602-605 (1995)
  94. Orimo A, Inoue S, Ikeda K, Noji S, Muramatsu M. Molecular cloning, structure and expression of mouse estrogen-responsive finger protein (efp); co-localization with estrogen receptor mRNA in target organs. J Biol Chem 270:24406-24413 (1995)
  95. Orimo A, Inoue S, Ouchi Y, Orimo H. Vascular smooth muscle cells possess estrogen receptor and respond to estrogen. Ann N Y Acad Sci 748:592-594 (1995)
  96. Inoue S, Orimo A, Hosoi T, Matsuse T, Kozaki K, Ouchi Y, Orimo H, Muramatsu M. Follistatin as an activin-binding protein expressed in arteriosclerotic lesions. Ann N Y Acad Sci 748:530-533 (1995)
  97. Inoue S, Orimo A, Matsuda Y, Inazawa J, Emi M, Nakamura Y, Hori T, Muramatsu M. Chromosome mappings of human and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. Genomics 25:581-583 (1995)
  98. Orimo A, Inouse S, Hoshino S, Saito T, Ikegami A, Kaneki M, Hoshoi T, Ouchi Y, Muramatsu M, Orimo H. Identification of isoforms of estrogen-receptor messenger RNA in the bone tissues. J Bone Mineral Res 10:S391 (1995)
  99. Kubo Y, Kikuchi Y, Mitani H, Kobayashi E, Kobayashi T, Hino O. Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model. Jpn J Cancer Res 86:828-832 (1995)
  100. Hino O, Kobayashi E, Hirayama Y, Kobayashi T, Kubo Y, Tsuchiya H, Kikuchi Y, Mitani H. Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2). Mol Carcinog 14:23-27 (1995)
  101. Kobayashi T, Nishizawa M, Hirayama Y, Kobayashi E, Hino O. cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model. Nucleic Acids Res 23:2608-2613 (1995)
  102. Kobayashi T, Hino O. The structure of the rat tuberous sclerosis (Tsc2) gene. Rat Genome 2:6-10 (1995) Review
  103. Hino O, Kobayashi T, Mitani H, Kobayashi E, Kubo Y, Tsuchiya H, Kikuchi Y, Nishizawa M, Hirayama Y. The EKER rat, a model of dominantly inherited cancer syndrome. Transplant Proc 27:1529-1531 (1995) Review
  104. Kobayashi T, Kawaguchi T, Kishino T, Matsumoto N, Niikawa N, Mori M, Levan G, Klinga-Levan K, Hino O. Isolation of microdissection clones from rat chromosome 10. Mamm Genome 6: 216-218 (1995)
  105. Kobayashi T, Hirayama Y, Kobayashi E, Kubo Y, Hino O. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Genet 9:70-4 (1995)
  106. Sato S, Kobayashi T, Hotta Y, Tabata S. Characterization of a mouse recA-like gene specifically expressed in testis. DNA Res 2:147-150 (1995)
  107. Kajino K, Jilbert AR, Saputelli J, Aldrich CE, Cullen J, Mason WS. Woodchuck hepatitis virus infections: very rapid recovery after a prolonged viremia and infection of virtually every hepatocyte. J Virol 68:5792-5803 (1994)
  108. Kajino K, Hotta Y, Hino O. Determination of a putative recombinogenic human hepatitis B virus sequence and its binding cellular protein. Cancer Res 54:3971-3973 (1994)
  109. Hino O, Kajino K. Hepatitis virus-related hepatocarcinogenesis. Intervirology 37:133-135 (1994)
  110. Inoue S, Orimo A, Hosoi T, Ikegami A, Kozaki K, Ouchi Y, Nomura S, Muramatsu M, Orimo H. Demonstration of activin-A in arteriosclerotic lesions. Biochem Biophys Res Commun 205:441-448 (1994)
  111. Tsuchiya H, Tsuchiya Y, Kobayashi T, Kikuchi Y, Hino O. Isolation of genes differentially expressed between the Yoshida sarcoma and long-survival Yoshida sarcoma variants: origin of Yoshida sarcoma revisited. Jpn J Cancer Res 85:1099-1104 (1994)
  112. Hino O, Kobayashi T, Tsuchiya H, Kikuchi Y, Kobayashi E, Mitani H, Hirayama Y. The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (TSC2) gene. Biochem Biophys Res Commun 203:1302-1308 (1994)
  113. Kobayashi T, Kobayashi E, Sato S, Hotta Y, Miyajima N, Tanaka A, Tabata S. Characterization of cDNAs induced in meiotic prophase in lily microsporocytes. DNA Res 1:15-26 (1994)
  114. Horiike N, Nonaka T, Kumamoto I, Kajino K, Onji M, Ohta Y. Hepatitis C virus plus- and minus- strand RNA in hepatocellular carcinoma and adjoining nontumorous liver. J Med Virol 41:312-315 (1993)
  115. Netter HJ, Kajino K, Taylor JM. Experimental transmission of human hepatitis delta virus to the laboratory mouse. J Virol 67:3357-3362 (1993)
  116. Netter HJ, Kajino K, Taylor JM. Replication of HDV in the mouse. Prog Clin Biol Res 382:171-173 (1993)
  117. Kajino K, Horiike N, Tanimoto K, Michitaka K, Nonaka T, Kanda K, Nakanishi K, Doi K, Masumoto T, Matsuura B, Onji M, Ohta Y. Significance of sublobular hepatic necrosis in the progression of chronic hepatitis C. J Gastroenterol Hepatol 8:224-227 (1993)
  118. Orimo A, Inoue S, Ikegami A, Hosoi T, Akishita M, Ouchi Y, Muramatsu M, Orimo H. Vascular smooth muscle cells as target for estrogen. Biochem Biophys Res Commun 195:730-736 (1993)
  119. Inoue S, Orimo A, Hosoi T, Kondo S, Toyoshima H, Kondo T, Ikegami A, Ouchi Y, Orimo H, Muramatsu M. Genomic binding-site cloning reveals a novel estrogen responsive gene that encodes a RING finger protein. Proc Natl Acad Sci USA 90:11117-11121 (1993)
  120. Inoue S, Orimo A, Hosoi T, Matsuse T, Hashimoto M, Yamada R, Ouchi Y, Orimo H, Muramatsu M. Expression of follistatin, an activin-binding protein in vascular smooth muscle cells and in arteriosclerotic lesions. Arterioscler Thromb 13:1859-1864 (1993)
  121. Kobayashi T, Hotta Y, Tabata S. Isolation and characterization of a yeast gene that is homologous with a meiosis-specific cDNA from a plant. Mol Gen Genet 237:225-232 (1993)
  122. Onji M, Kikuchi T, Kumon I, Masumoto T, Nadano S, Kajino K, Horiike N, Ohta Y. Intrahepatic lymphocyte subpopulations and HLA class I antigen expression by hepatocytes in chronic hepatitis C. Hepatogastroenterology 39:340-343 (1992)
  123. Akishita M, Ouchi Y, Kozaki K, Orimo A, Hattori A, Orimo H. Accuracy and reliability of quantitative measurement of coronary arterial stenosis by videodensitometry on coronary angiogram. Jpn Heart J 33:631-641 (1992)
  124. Ohyama T, Iwaikawa Y, Kobayashi T, Hotta Y, Tabata S. Isolation of synaptonemal complexes from lily microsporocytes. Plant Sci 86: 115-124 (1992)
  125. Michitaka K, Onji M, Horiike N, Kajino K, Saito I, Miyamura T, Ohta Y. Intrafamilial transmission of hepatitis C virus in Japan. Gastroenterol Jpn 26:619-622 (1991)
  126. Kajino K, Ogawa Y, Michitaka K, Nadano S, Onji M, Horiike N, Kikuchi T, Nonaka T, Kanda K, Masumoto T, Nakanishi K, Matsuura B, Doi K, Ohta Y. Characteristic laparoscopic findings of chronic hepatitis C: a comparison with chronic hepatitis B. Dig Endosc 3:235-239 (1991)
  127. Kajino K, Onji M, Matsuura B, Masumoto T, Nonaka T, Nakanishi K, Doi K, Michitaka K, Horiike N, Ohta Y. A case of primary biliary cirrhosis: Improvement of jaundice by the combined therapy with UDCA and Inchinkoto. Ehime Igaku 10: 264-265 (1991)
  128. Onji M, Yamaguchi S, Masumoto T, Akbar SM, Kajino K, Ohta Y. Induction of the interleukin-2 receptor (p55) by interferons. J Interferon Res 11:237-1241 (1991)
  129. Yuasa T, Kajino K, Saito I, Miyamura T. Preferential expression of the large hepatitis B virus surface antigen gene by an adenovirus-hepatitis B virus recombinant. J Gen Virol 72:1927-1934 (1991)
  130. Kajino K, Ohta Y, Miyamura T, Saito I. Efficient cloning of hepatitis B virus DNA from single-stranded replicative intermediates and its application to S1 mapping of viral RNA in human liver tissue. J Med Virol 33:33-38 (1991)
  131. Nakanishi K, Michitaka K, Matsuura B, Kikuchi K, Nonaka T, Kanda K, Masumoto T, Kajino K, Onji M, Ohta Y. Peritoneoscopic findings of liver in patients with severe type of acute hepatitis. Gastroenterol Endosc 33:725-732 (1991)
  132. Kikuchi T, Onji M, Kajino K, Michitaka K, Horiike N, Ohta Y. Clinicopathological study of anti-hepatitis C virus antibody positive non-A, non-B liver diseases. Ehime Igaku 10:40-43 (1991)
  133. Suzuki T, Kajino K, Masui N, Saito I, Miyamura T. Alternative splicing of hepatitis B virus RNAs in HepG2 cells transfected with the viral DNA. Virology 179:881-885 (1990)
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