スタッフ紹介、研究、業績等、順天堂大学大学院感染制御科学に関する様々な情報をご案内します。


業績


 

英文

 
  • Effect of PMX-DHP for sepsis due to ESBL-producing E. coli in an extremely low-birthweight infant. Nishizaki N, Nakagawa M, Hara S, Oda H, Kantake M, Obinata K, Uehara Y, Hiramatsu K, Shimizu T. Pediatr Int. 2015 Dec 29. doi: 10.1111/ped.12825.
  • Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis. Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K. Sci Rep. 2015 Nov 25;5:17092. doi: 10.1038/srep17092.
  • Complete Genome Sequence of the Drug-Naive Classical Staphylococcus aureus Strain FDA209P.Singh M, Sasaki T, Matsuo M, Morimoto Y, Aiba Y, Hiramatsu K. Genome Announc. 2015 Nov 12;3(6).
  • Apigenin as an anti-quinolone-resistance antibiotic. Morimoto Y, Baba T, Sasaki T, Hiramatsu K. Int J Antimicrob Agents. 2015 Dec;46(6):666-73.
  • Complete Genome Sequence of Methicillin-Resistant Staphylococcus schleiferi Strain TSCC54 of Canine Origin. Sasaki T, Tsubakishita S, Kuwahara-Arai K, Matsuo M, Lu YJ, Tanaka Y, Hiramatsu K.Genome Announc. 2015 Oct 29;3(5).
  • Matsuo M, Hishinuma T, Katayama Y, Hiramatsu K. A mutation of RNA polymerase β' subunit (RpoC) converts heterogeneously vancomycin-intermediate S. aureus (hVISA) into 'slow-VISA' (sVISA).Antimicrob Agents Chemother. 2015 May 4. pii: AAC.00135-15. [Epub ahead of print]
  • Ohsawa H, Baba T, Enami J, Hiramatsu K. Successful selection of an infection-protective anti-Staphylococcus aureus monoclonal antibody and its protective activity in murine infection models. Microbiol Immunol. 2015 Apr;59(4):183-92.
  • Saito M, Katayama Y, Hishinuma T, Iwamoto A, Aiba Y, Kuwahara-Arai K, Cui L, Matsuo M, Aritaka N, Hiramatsu K. 'Slow VISA' (sVISA), a novel phenotype of vancomycin resistance, obtained in vitro from hVISA strain Mu3. Antimicrob Agents Chemother. 2014 Sep;58(9):5024-35.
  • Nakao A, Ito T, Han X, Lu YJ, Hisata K, Tsujiwaki A, Matsunaga N, Komatsu M, Hiramatsu K, Shimizu T. Intestinal carriage of methicillin-resistant Staphylococcus aureus in nasal MRSA carriers hospitalized in the neonatal intensive care unit. Antimicrob Resist Infect Control. 2014 Apr 23;3:14. doi: 10.1186/2047-2994-3-14. eCollection 2014.
  • Ito T, Kuwahara-Arai K, Katayama Y, Uehara Y, Han X, Kondo Y, Hiramatsu K. Staphylococcal Cassette Chromosome mec (SCCmec) analysis of MRSA. Methods Mol Biol. 2014;1085:131-48. doi: 10.1007/978-1-62703-664-1_8.
  • Matsuo M, Cui L, Kim J, Hiramatsu K. Comprehensive identification of mutations responsible for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA)-to-VISA conversion in laboratory-generated VISA strains derived from hVISA clinical strain Mu3. Antimicrob Agents Chemother. 2013 Dec;57(12):5843-53. doi: 10.1128/AAC.00425-13.
  • Aiba Y, Katayama Y, Hishinuma T, Murakami-Kuroda H, Cui L, Hiramatsu K. Mutation of RNA polymerase β-subunit gene promotes heterogeneous-to-homogeneous conversion of β-lactam resistance in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Oct;57(10):4861-71. doi: 10.1128/AAC.00720-13.
  • Lulitanond A, Ito T, Li S, Han X, Ma XX, Engchanil C, Chanawong A, Wilailuckana C, Jiwakanon N, Hiramatsu K. ST9 MRSA strains carrying a variant of type IX SCCmec identified in the Thai community. BMC Infect Dis. 2013 May 11;13:214. doi: 10.1186/1471-2334-13-214.
  • Zhang M, Ito T, Li S, Misawa S, Kondo S, Miida T, Ohsaka A, Hiramatsu K. Analysis of Staphylococcal Cassette Chromosome mec in BD GeneOhm™ MRSA Assay negative strains. Antimicrob Agents Chemother. 2013 Jun;57(6):2890-1.
  • Ohkushi D, Uehara Y, Iwamoto A, Misawa S, Kondo S, Shimizu K, Hori S, Hiramatsu K. An effective active surveillance method for controlling nosocomial MRSA transmission in a Japanese hospital. J Infect Chemother. 2013 Apr 5. [Epub ahead of print]
  • Notake S, Matsuda M, Tamai K, Yanagisawa H, Hiramatsu K, Kikuchi K. Detection of IMP metallo-β-lactamase in carbapenem-non-susceptible Enterobacteriaceae and glucose non-fermenting Gram-negative rods by immunochromatography assay. J Hosp Infect. 2013 May;84(1):81-4.
  • Uehara Y, Kuwahara-Arai K, Hori S, Kikuchi K, Yanai M, Hiramatsu K. Investigation of nasal meticillin-resistant Staphylococcus aureus carriage in a haemodialysis clinic in Japan. J Hosp Infect. 2013 May;84(1):81-4.
  • Katayama Y, Baba T, Sekine M, Fukuda M, Hiramatsu K. Beta-hemolysin promotes skin colonization by Staphylococcus aureus. J Bacteriol. 2013 Mar;195(6):1194-203.
  • Mariem BJ, Ito T, Zhang M, Jin J, Li S, Ilhem BB, Adnan H, Han X, Hiramatsu K. Molecular characterization of methicillin-resistant Panton-valentine leukocidin positive staphylococcus aureus clones disseminating in Tunisian hospitals and in the community. BMC Microbiol. 2013 Jan 7;13:2.
  • Matsuda N, Matsuda M, Notake S, Yokokawa H, Kawamura Y, Hiramatsu K, Kikuchi K. Expression and functional characterization of retinoic acid-inducible gene-I-like receptors of mast cells in response to viral infection. J Clin Microbiol. 2012 Dec;50(12):3862-6.
  • Cui L, Neoh HM, Iwamoto A, Hiramatsu K. Coordinated phenotype switching with large-scale chromosome flip-flop inversion observed in bacteria. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):E1647-56.
  • Hiramatsu K, Igarashi M, Morimoto Y, Baba T, Umekita M, Akamatsu Y. Curing bacteria of antibiotic resistance: reverse antibiotics, a novel class of antibiotics in nature. Int J Antimicrob Agents. Jun;39(6):478-85. 2012
  • Sasaki T, Tsubakishita S, Tanaka Y, Ohtsuka M, Hongo I, Fukata T, Kabeya H, Maruyama S, Hiramatsu K. Population genetic structures of Staphylococcus aureus isolates from cats and dogs in Japan. J Clin Microbiol. 2012 Jun;50(6):2152-5.
  • Yamakawa J, Aminaka M, Okuzumi K, Kobayashi H, Katayama Y, Kondo S, Nakamura A, Oguri T, Hori S, Cui L, Ito T, Jin J, Kurosawa H, Kaneko K, Hiramatsu K. Heterogeneously vancomycin-intermediate Staphylococcus aureus (hVISA) emerged before the clinical introduction of vancomycin in Japan: a retrospective study. J Infect Chemother. 2012 Jun;18(3):406-9.
  • Zhang M, Ito T, Li S, Jin J, Takeuchi F, Lauderdale TL, Higashide M, Hiramatsu K. Identification of the third type of PVL phage in ST59 methicillin-resistant Staphylococcus aureus (MRSA) strains. FEMS Microbiol Lett. 632011 Oct;323(1):20-8. doi: 10.1111/j.1574-6968.2011.02355.x.
  • Hirotaki S, Sasaki T, Kuwahara-Arai K, Hiramatsu K. Rapid and accurate identification of human-associated staphylococci by multiplex PCR. J Clin Microbiol. 2011 Oct;49(10):3627-31.
  • Watanabe Y, Naito T, Kikuchi K, Amari Y, Uehara Y, Isonuma H, Hisaoka T, Yoshida T, Yaginuma K, Takaya N, Daida H, Hiramatsu K. Infective endocarditis with Lactococcus garvieae in Japan: a case report. J Med Case Reports. 2011 Aug 9;5:356.
  • Matsuo M, Hishinuma T, Katayama Y, Cui L, Kapi M, Hiramatsu K. Mutation of RNA Polymerase {beta} Subunit (rpoB) Promotes hVISA-to-VISA Phenotypic Conversion of Strain Mu3. Antimicrob Agents Chemother. 2011 Sep;55(9):4188-95.
  • Higashiyama M, Ito T, Han X, Tanno A, Wada T, Funaoka Y, Yoshida Y, Mikita K, Ogawa T, Nishiyama J, Okusa Y, Kaku K, Hatada J, Hiramatsu K, Kawana A. Trial to control an outbreak of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus at a boarding school in Japan. Am J Infect Control. 2011 Dec;39(10):858-65.
  • Hisata K, Ito T, Matsunaga N, Komatsu M, Jin J, Li S, Watanabe S, Shimizu T, Hiramatsu K. Dissemination of multiple MRSA clones among community-associated methicillin-resistant Staphylococcus aureus infections from Japanese children with impetigo. J Infect Chemother. 2011 Oct;17(5):609-21.
  • Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K. Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence. PLoS Pathog. 7,e1001267, 2011
  • Li S, Skov RL, Han X, Larsen AR, Larsen J, Sørum M, Wulf M, Voss A, Hiramatsu K, Ito T. Novel types of staphylococcal cassette chromosome mec elements identified in clonal complex 398 methicillin resistant Staphylococcus aureus strains. Antimicrob Agents Chemother. Jun;55(6):3046-50. 2011
  • Shoji M, Cui L, Iizuka R, Komoto A, Neoh HM, Watanabe Y, Hishinuma T, Hiramatsu K. WalK and ClpP Mutations Confer Decreased Susceptibility to Vancomycin in Staphylococcus aureus. Antimicrob Agents Chemother. In press 2011
  • Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I Human anti-microbial cathelicidin peptide LL-37 suppresses the LPS-induced apoptosis of endothelial cells. Int Immunol. Mar;23(3):185-93. 2011
  • Watanabe Y, Cui L, Katayama Y, Kozue K, Hiramatsu K. Impact of RpoB Mutations on Decreased Susceptibility to Vancomycin in Staphylococcus aureus. J Clin Microbiol. Apr 27. [Epub ahead of print] 2011
  • Zhang M, O'Donoghue MM, Ito T, Hiramatsu K, Boost MV. Prevalence of antiseptic-resistance genes in Staphylococcus aureus and coagulase-negative staphylococci colonising nurses and the general population in Hong Kong. J Hosp Infect. Jun;78(2):113-7. 2011
   
 

和文

 
  • 家田健史、繻エ京子、森本ゆふ、久末伸一、伊藤輝代、堀江重郎、平松啓一. 尿路感染症主要原因菌のフルオロキノロン系抗菌薬を中心とした薬剤に対する感受性および gyrA・parC における QRDR の遺伝子変異の解析. 日本化学療法学会雑誌 2015 63(3):343-349.
  • 細谷志乃、伊藤輝代、三澤成毅、吉池高志、小栗豊子、平松 啓一. 皮膚科外来患者由来 MRSA 株に見られる新規 MRSA クローンの出現状況. 感染症学雑誌 2014 Nov;88(6):840-8.
  • 香本晃良, 崔龍洙、江端望、渡辺由希子、松尾美記、片山由紀、Piyamas Petcharoen、平松啓一. 黄色ブドウ球菌におけるRNAポリメラーゼ遺伝子の突然変異はLinezolidの高感受性化に関連する. 順天堂医学58(6):498-505 2012
  • 金京勲、伊藤輝代、平松啓一. 世界各地で分離されたVancomycin-intermediate S. aureus 46株の分子疫学的解析. 順天堂医学57:494-503 2011
  • 小野由可、菊池賢、Xun J、堀賢、平松啓一. linezolid 治療中に出現した縦隔炎患者由来 methicillin − resistant Staphylococcus aureus のlinezolid 耐性機構. 順天堂医学57:370-6 2011
  • 高橋並子、澤村正之、菊池賢、平松啓一. 多剤耐性淋菌に対するニトロフラントイン,ホスホマイシンを含む代替治療候補としての抗菌薬の感受性. 順天堂医学57(4)365-369 2011
  • 関根美和・馬場 理・片山 由紀・平松 啓一. 黄色ブドウ球菌MHC様分子が貪食などの宿主免疫系に及ぼす影響について順天堂医学 57:232-242 2011
   
 

著書

 
  • 「感染対策実践マニュアル 第3版 考え方と運営のポイント」堀 賢 (編集) じほう; 第3版 (2015/12/25)
  • 「すぐに役立つ! 感染対策実践マニュアル 第2版 ―医療安全管理・運営のポイント」堀 賢 (編集) じほう; 第2版 (2010/11/30)
 


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