研究テーマ「マラリア原虫の有性生殖機構解析とそれを利用した新規抗マラリア対策の構築」

マラリア撲滅に向けた対策の１つとして、「ヒトー媒介蚊間の伝播阻止」が注目されています。現在、マラリア原虫のmosquito stageの一部を占める有性生殖を標的とし、マラリア原虫の受精（次世代の伝播）を阻害する新規手法および解析法の開発を目指して研究を進めています。

原著論文

1. Okamoto M., Yamada L., Fujisaki Y., Bloomfield G., Yoshida K., Kuwayama H., Sawada H., Mori T., Urushihara H. Two HAP2-GCS1 homologs responsible for gamete interactions in the cellular slime mold with multiple mating types: Implication for common mechanisms of sexual reproduction shared by plants and protozoa and for male-female differentiation. Dev Biol 2016. 415: 6-13. PMID: 27189178
2. Hamaji T., Mogi Y., Ferris P.J., Mori T., Miyagishima S., Kabeya Y., Nishimura Y., Toyoda A., Noguchi H., Fujiyama A., Olson B.J., Marriage T.N., Nishii I., Umen J.G., Nozaki H. Sequence of the Gonium pectorale mating locus reveals a complex and dynamic history of changes in volvocine algal mating haplotypes. G3 (Bethesda) 2016. 6:1179-1189. PMID: 26921294
3. Maruyama D., Völz R., Takeuchi H., Mori T., Igawa T., Kurihara D., Kawashima T., Ueda M., Itoh M., Umeda M., Nishikawa S., Groß-Hardt R., Higashiyama T. Rapid elimination of the persistent synergid through a cell-fusion for polytubey block. Cell 2015. 161: 907-918. PMID: 25913191
4. Ebchuqin E., Yokota N., Yamada L., Yasuoka Y., Akasaka M., Arakawa M., Deguchi R. Mori T., Sawada H. Evidence for participation of GCS1 in fertilization of the starlet sea anemone Nematostella vectensis: Implication of a common mechanism of sperm-egg fusion in plants and animals. Biochem Biophys Res Commun 2014. 451, 522-528. PMID: 25111819
5. Kawai-Toyooka H., Mori T., Hamaji T., Suzuki M., Olson B.J., Uemura T., Ueda T., Nakano A., Toyoda A., Fujiyama A. and Nozaki H. Sex-specific post-translational regulation of the gamete fusogen GCS1 in the isogamous volvocine alga Gonium pectorale. Eukaryot Cell 2014. 13: 648-656. PMID: 24632243
6. Mori T., Igawa T., Tamiya G., Miyagishima S.Y., Berger F. Gamete attachment requires GEX2 for successful fertilization in Arabidopsis. Curr Biol 2014. 24: 170-175. PMID: 24388850
7. Igawa T., Yanagawa Y., Miyagishima S., Mori T. Analysis of gamete membrane dynamics during double fertilization of Arabidopsis. J Plant Res 2013. 126: 387-394. PMID: 23076439
8. Mogi Y., Hamaji T., Suzuki M., Ferris P., Mori T., Kabeya Y. Miyagishima S., Nozaki H. Evidence for tubular mating structures induced in each mating type of heterothallic Gonium pectorale (Volvocales, Chlorophyta). J Phycol 2012. 48: 670-674. PMID: 27011083
9. Itoh K., Izumi A., Mori T., Dohmae N., Yui R., Maeda-Sano K., Shirai Y., Kanaoka M.M., Kuroiwa T., Higashiyama T., Sugita M., Murakami-Murofushi K., Kawano S., Sasaki N. DNA packaging proteins Glom and Glom2 coordinately organize the mitochondrial nucleoid of Physarum polycephalum. Mitochondrion 2011. 11: 575-586. PMID: 21406253
10. Mori T*., Hirai M*., Kuroiwa T., Miyagishima S. The functional domain of GCS1-based gamete fusion resides in the amino terminus in plant and parasite species. PLoS ONE 2010. 5: e15957. *equal contribution. PMID: 21209845
11. Itoh K., Izumi A., Mori T., Dohmae N., Yui R., Maeda-Sano K., Kanaoka M.M., Kuroiwa H., Kuroiwa T., Higashiyama T. Murakami-Murofushi K., Kawano S. and Sasaki N. New protein Pmn34 with an exonuclease motif localizes in the mitochondrial nucleoid periphery of Physarum polycephalum. Cytologia 2009. 74: 401-407. J-STAGE
12. Brownfield L., Hafidh S., Borg M., Sidorova A., Mori T., Twell D. A plant germline-specific integrator of sperm specification and cell cycle progression. PLoS Genet 2009. 5: e1000430. PMID: 19300502
13. Okazaki K., Kabeya Y., Suzuki K., Mori T., Ichikawa T., Matsui M., Nakanishi H., Miyagishima S. The PLASTID DIVISION1 and 2 components of the chloroplast division machinery determine the rate of chloroplast division in land plant cell differentiation. Plant Cell 2009. 21: 1769-1780. PMID: 19567705
14. Hirooka S., Misumi O., Yoshida M., Mori T., Nishida K., Yagisawa F., Yoshida Y., Fujiwara T., Kuroiwa H., Kuroiwa T. Expression of the Cyanidioschyzon merolae stromal ascorbate peroxidase in Arabidopsis thaliana enhances thermotolerance. Plant Cell Rep 2009. 28: 1881-1893. PMID: 19859717
15. Fujiwara T., Misumi O., Tashiro K., Yoshida Y., Nishida K., Yagisawa F., Imamura S., Yoshida M., Mori T., Tanaka K., Kuroiwa H., Kuroiwa T. Periodic gene expression patterns during the highly synchronized cell nucleus and organelle division cycles in the unicellular red alga Cyanidioschyzon merolae. DNA Res 2009. 16: 59-72. PMID: 19147531
16. Hirai M*., Arai M*., Mori T*., Miyagishima S., Kawai S., Kita K., Kuroiwa T., Terenius O., Matsuoka H. Male fertility of malaria parasites is determined by GCS1, a plant-type reproduction factor. Curr Biol 2008. 18: 607-613. * equal contribution. PMID: 18403203
17. Nozaki H., Mori T., Misumi O., Matsunaga S., Kuroiwa T. Males evolved from the dominant isogametic mating type. Curr Biol 2006. 16: R1018-R1020. PMID: 17174904
18. Higashiyama T., Inatsugi R., Sakamoto S., Sasaki N., Mori T., Kuroiwa H., Nakada T., Nozaki H., Kuroiwa T., Nakano A. Species preferentiality of the pollen tube attractant derived from the synergid cell of Torenia fournieri. Plant Physiol 2006. 142: 481-491. PMID: 16935992
19. Mori T., Kuroiwa H., Higashiyama T., Kuroiwa T. GENERATIVE CELL SPECIFIC 1 is essential for angiosperm fertilization. Nat Cell Biol 2006. 8: 64-71. PMID: 16378100
20. Misumi O., Matsuzaki M., Nozaki H., Miyagishima S., Mori T., Nishida K., Yagisawa F., Yoshida Y., Kuroiwa H., Kuroiwa T. Cyanidioschyzon merolae genome. A tool for facilitating comparable studies on organelle biogenesis in photosynthetic eukaryotes. Plant Physiol 2005. 137: 567-585. PMID: 15681662
21. Matsuzaki M., Misumi O., Shin-i T., Maruyama S., Takahara M., Miyagishima S., Mori T., Nishida K., Yagisawa F., Nishida K., Yoshida Y., Nishimura Y., Nakao S., Kobayashi T., Momoyama Y., Higashiyama T., Minoda A., Sano M., Nomoto H., Oishi K., Hayashi H., Ohta F., Nishizaka S., Haga S., Miura S., Morishita T., Kabeya Y., Terasawa K., Suzuki Y., Ishii Y., Asakawa S., Takano H., Ohta N., Kuroiwa H., Tanaka K., Shimizu N., Sugano S., Sato N., Nozaki H., Ogasawara N., Kohara Y., Kuroiwa T. Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D. Nature 2004. 428: 653-657. PMID: 15071595
22. Yagisawa F, Mori T., Higashiyama T, Kuroiwa H, Kuroiwa T. Regulation of Brassica rapa chloroplast proliferation in vivo and in cultured leaf disks. Protoplasma 2003. 222: 139-148. PMID: 14714202
23. Momoyama Y., Miyazawa Y., Miyagishima S., Mori T., Misumi O., Kuroiwa H., Kuroiwa T. The division of pleomorphic plastids with multiple FtsZ rings in tobacco BY-2 cells. Eur J Cell Biol 2003. 82: 323-332. PMID: 12868600
24. Miyagishima S., Nishida K., Mori T., Kuroiwa H., Higashiyama T., Kuroiwa T. A plant-specific dynamin-related protein forms a ring at the chloroplast division site. Plant Cell 2003. 15: 655-665. PMID: 12615939
25. Mori T., Kuroiwa H., Higashiyama T., Kuroiwa T. Identification of higher plant GlsA, a putative morphogenesis factor of gametic cells. Biochem Biophys Res Common 2003. 306: 564-569. PMID: 12804602
26. Kuroiwa H., Mori T., Takahara M., Miyagishima S., Kuroiwa T. Chloroplast division machinery as revealed by immunofluorescence and electron microscopy. Planta 2002. 215: 185-190. PMID: 12029466
27. Takahara M., Kuroiwa H., Miyagishima S., Mori T., Kuroiwa T. Localization of the mitochondrial FtsZ protein in a dividing mitochondrion. Cytologia 2001. 66: 421-425. J-STAGE
28. Miyazawa Y., Mori T., Kobayashi T., Momoyama Y., Kuroiwa H., Kuroiwa T. Visualization of multiple FtsZ rings in activity dividing proplastids of cultured Bright Yellow-2 tobacco cells. Cytologia 2001. 66: 415-419. J-STAGE
29. Miyagishima S., Takahara M., Mori T., Kuroiwa H., Higashiyama T., Kuroiwa T. Plastid division is driven by a complex mechanism that involves differential transition of the bacterial and eukaryotic division rings. Plant Cell 2001. 13: 2257-2268. PMID: 11595800
30. Kuroiwa H., Mori T., Takahara M., Miyagishima S., Kuroiwa T. Multiple FtsZ rings in a pleomorphic chloroplast in embryonic cap cells of Pelargonium zonale. Cytologia 2001. 66: 227-233. J-STAGE
31. Mori T., Kuroiwa H., Takahara M., Miyagishima S., Kuroiwa T. Visualization of an FtsZ ring in chloroplasts of Lilium longiflorum leaves. Plant Cell Physiol 2001. 42: 555-559. PMID: 11427673
32. Mori T., Takahara T., Miyagishima S., Kuroiwa H., Kuroiwa T. Visualization of FtsZ rings in plastids of the microspore in Lilium longiflorum. Cytologia 2001. 66: 113-115. J-STAGE
33. Mori T., Tanaka I. Isolation of the ftsZ gene from plastid-deficient generative cells of Lilium longiflorum. Protoplasma 2000. 214: 57-64. Springer Link

原著論文（和文）

1. 森 稔幸. 動植物・原生生物における共通受精機構の発見: 進化的に保存されたboy-meets-girl. 科学, 岩波書店, 2014. 84(7): 784-786. CiNii
2. 森 稔幸. 花の中の逢瀬. 生物の科学・遺伝, NTS, 2006. 60(2): 5-8. J-GLOBAL

総説

1. Mori T., Kawai-Toyooka H., Igawa T., Nozaki H. Gamete dialogs in green lineages. Mol Plant 2015. 8: 1442-1454. PMID: 26145252
2. Mori T., Igawa T. Gamete attachment process revealed in flowering plant fertilization. Plant Signal Behav 2014. 9: e977715. PMID: 25517689
3. Igawa T., Mori T. Gamete membrane dynamics during double fertilization in Arabidopsis. Plant Signal Behav 2013. 8: e24512. PMID: 23603960
4. Hirai M*., Mori T*. Fertilization is a novel attacking site for the transmission blocking of malaria parasites. Acta Trop 2010. 114: 157-161. * equal contribution. PMID: 19665985
5. Mori T. Elucidating the molecular mechanics of the final stages of double fertilization. Plant Morphol 2010. 22: 9-13 (2010). J-STAGE
6. 森 稔幸. 被子植物の受精を決定づける最終因子. Plant Morphol 2006. 18: 55-60. J-STAGE
7. Kuroiwa T., Nishida K., Yoshida Y., Fujiwara T., Mori T., Kuroiwa H., Misumi O. Structure, function and evolution of the mitochondrial division apparatus. Biochim Biophys Acta 2006. 1763: 510-521. PMID: 16690143

著書

1. Mori T. Profiling the GCS1-based gamete fusion mechanism. Sexual Reproduction in Animals and Plants, Springer, 2014. 329-335. Springer Link
2. 森 稔幸, 平井 誠. 配偶子融合：動植物・原生生物の受精に共通する配偶子融合因子. 動植物の受精学, 化学同人, 2014. 32-42. 動植物の受精学