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20212020201920182017201620152014~

2021

• Mijiti N, Someya A, Nagaoka I: Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells. Exp Ther Med 2021 (in press)
• Iba T, Levy JH, Aihara K, Kadota K, Tanaka H, Sato K, Nagaoka I: Newly developed recombinant antithrombin protects the endothelial glycocalyx in an endotoxin-induced rat model of sepsis. Int J Mol Sci 22: 176, 2021.

2020

• Yamaguchi K, Yamazaki S, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I: Yokukansan, a Japanese herbal medicine, suppresses substance P-induced production of interleukin-6 and interleukin-8 by human U373 MG glioblastoma astrocytoma cells. Endocr Metab Immune Disord Drug Targets 20: 1073-1080, 2020.
• Kumagai Y, Murakami T, Kuwahara-Arai K, Iba T, Reich J, Nagaoka I: Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils. Innate Immun 26: 565-579, 2020.
• Yamagishi Y, Someya A, Nagaoka I: Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine. Biomed Rep 13: 37-42, 2020.

2019

• Tomiki Y, Saito K, Arikawa-Hirasawa E, Mita T, Shimizu T, Suzuki T, Ohnuma T, Ohtomo Y, Nagaoka I: Club activities of medical students at Juntendo University -Changes of membership over the 30-year Heisei Era- Juntendo Med J 65: 172-178, 2019.
• Suzuki K, Ohkuma M, Nagaoka I: Bacterial lipopolysaccharide and antimicrobial LL-37 induce the enhanced expression of ICAM-1 and phosphorylation of NF-κB p65 in senescent endothelial cells. Int J Mol Med 44: 1187-1196, 2019.
• Abe Y, Sakuyama N, Sato T, Kishine K, Nagayasu K, Nakatani A, Kitajima M, Watanabe T, Nishimura K, Ochiai T, Nagaoka I: Evaluation of 5-fluorouracil plasma level in colorectal cancer patients undergoing continuous infusion chemotherapy. Mol Clin Oncol 11: 289-295, 2019.
• Sugiyama Y, Naito K, Goto K, Kojima Y, Furuhata A, Igarashi M, Nagaoka I, Kaneko K: Effect of aging on the tendon structure and tendon associated-gene expression in mouse foot flexor tendon. Biomed Rep 10: 238-244, 2019.
• Reich J, Alexander Weyer F, Tamura H, Nagaoka I, Motschmann H: Low Endotoxin Recovery—Masking of Naturally Occuring Endotoxin. Int J Mol Sci 20: 838, doi:10.3390/ijms20040838, 2019.

2018

• Takahashi T, Tomonaga A, Watanabe K, Tsuboi M, Nagaoka I: Evaluation of the efficacy and safety of long-term intake of a dietary supplement containing salmon nasal cartilage-derived proteoglycan on subjects with subjective knee symptoms -An open study- Jpn Pharmacol Ther 46: 1693-1706, 2018.
• Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I: MrgX2-mediated internalization of LL-37 and degranulation of human LAD2 mast cells. Mol Med Reports 18: 4951-4959, 2018
• Iba T, Levy JH, Hirota T, Hiki M, Sato K, Murakami T, Nagaoka I: Protection of the endothelial glycocalyx by antithrombin in an endotoxin-induced rat model of sepsis. Thrombosis Research 171: 1-6, 2018.
• Tsuruta A, Horiike T, Yoshimura M, Nagaoka I: Evaluation of the effect of the administration of a glucosamine-containing supplement on biomarkers for cartilage metabolism in soccer players: a randomized double-blind placebo-controlled study. Mol Med Reports 18: 3941-3948, 2018.
• Yoshikawa T, Miyamoto M, Aoyama T, Soyama H, Goto T, Hirata J, Suzuki A, Nagaoka I, Tsuda H, Furuya K, Takano M: JAK2/STAT3 pathway as a therapeutic target in ovarian cancers. Oncol Lett 15: 5772-5780, 2018.
• Reich J, Tamura H, Nagaoka I, Motschmann H: Investigation of the kinetics and mechanism of low endotoxin recovery in a matrix for biopharmaceutical drug products. Biologicals 53: 1-9, 2018.
• Komatsu J, Nagura N, Iwase H, Igarashi M, Ohbayashi O, Nagaoka I, Kaneko K: Effect of intermittent teriparatide on the mechanical and histological changes in bone grafted with β-tricalcium phosphate using a rabbit bone defect model. Exp Ther Med 15: 19-30, 2018.
• Iba T, Hirota T, Sato K, Nagaoka I: Protective effect of a newly developed fucose-deficient recombinant antithrombin against histone-induced endothelial damage. Int J Hematol doi: 10.1007/s12185-018-2402-x, 2018.

2017

• Yoshikawa T, Takano M, Miyamoto M, Yajima I, Shimizu Y, Aizawa Y, Suguchi Y, Moriiwa M, Aoyama T, Soyama H, Goto T, Hirata J, Suzuki A, Sasa H, Nagaoka I, Tsuda H, Furuya K: Psoas muscle volume as a predictor of peripheral neurotoxicity induced by primary chemotherapy in ovarian cancers. Cancer Chemother Pharmacol 80: 555-561, 2017.
• Iba T, Sasaki T, Ohshima K, Sato K, Nagaoka I, Thachil J: The comparison of the protective effects of α- and β-antithrombin against vascular endothelial cell damage induced by histone in vitro. TH Open 2017; 01(01): e3-e10 DOI: 10.1055/s-0037-1603926
• Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I: Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells. Mol Med Reports 16: 1353-1359, 2017.
• Sawada Y, Sugimoto A, Hananouchi T, Sato N, Nagaoka I: Evaluation of the efficacy of Ajuga decumbens extract supplement in individuals with knee discomfort associated with physical activity: a randomized, double-blind, placebo-controlled study. Exp Ther Med 14: 4561-4571, 2017.
• Kubomura D, Ueno T, Yamada M, Nagaoka I: Evaluation of the chondroprotective action of N-acetylglucosamine on a rat experimental osteoarthritis model. Exp. Ther. Med. 14: 3137-3144, 2017.
• Tomonaga A, Fukagawa M, Suzuki A, Kurokawa M, Nagaoka I: Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals: a randomized double-blind placebo-controlled clinical study. Functional Foods in Health and Disease 7: 604-627, 2017.
• Tomonaga A, Takahashi T, Tsuda-Tanaka Y, Tsuboi M, Ito K, Nagaoka I: Evaluation of the effect of the administration of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: a randomized double-blind placebo-controlled clinical study. Exp Ther Med 14: 115-126, 2017
• Aoyama T, Takano M, Miyamoto M, Yoshikawa T, Soyama H, Kato K, Ishibashi H, Iwahashi H, Nakatsuka M, Yajima I, Shimizu Y, Aizawa Y, Suguchi Y, Moriiwa M, Goto T, Sasa H, Nagaoka I, Tsuda H, Furuya K: Is there any predictor for hypersensitivity reactions in gynecologic cancer patients treated with paclitaxel-based therapy? Cancer Chemother Pharmacol 80: 65-69, 2017.
• Yamaguchi K, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I: Anti-inflammatory actions of gabapentin and pregabalin on the substance P-induced mitogen-activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells. Mol Med Reports 16: 6109-6115, 2017.
• Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I: Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model. Mol Med Reports 16: 5618-5626, 2017.
• Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Nagayasu K, Naito S, Sato T, Kishine K, Abe Y, Hara C, Yamada S, Mashiko S, Nagaoka I: Impact of the individualization on the first-line chemotherapy for advanced colorectal cancer based on collagen gel droplet-embedded drug sensitivity test. Oncol Lett Oncol Lett 14: 6045-6052, 2017.
• Iba T, Sasaki T, Ohshima K, Sato K, Nagaoka I, Thachil J: The comparison of the protective effects of α- and β-antithrombin against vascular endothelial cell damage induced by histone in vitro. TH Open 2017 (in press)
• Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo V, Ishizawa J, Ikegami T, Kazuno S, Igarashi M, Matsushita M, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M: Survival of acute monocytic leukemia cells is driven by fatty acid oxidation-mediated activation of AMPK in bone marrow adipocytes. Cancer Res (in press) 2017. 2CAN-16-1645R
• Igarashi M, Sakamoto K, Nagaoka I: Effect of glucosamine on the expression of the genes for type II collagen, matrix metalloproteinases and sirtuins in a human chondrocyte cell line. Int J Mol Med 39: 472-478, 2017.
• Hu Z, Murakami T, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoka I: Neutrophil extracellular traps (NETs) induces the IL-1b production by macrophages in combination with lipopolysaccharide. Int J Mol Med 39: 549-558, 2017.
• Yamaguchi K, Kumakura S, Murakami T, Someya A, Inada E, Nagaoka I: Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells. Int J Mol Med 39: 687-692, 2017.
• Kubomura, D., Ueno, T., Yamada, M., Tomonaga, A., Nagaoka, I.: Effect of N-acetylglucosamine administration on cartilage metabolism and safety in healthy subjects without symptoms of arthritis: a case report. Exp Ther Med 13: 1614-1621, 2017.
• Hashiguchi M, Suzuki K, Kaneko K, Nagaoka I: Evaluation of the effect of aloe-emodin on the proliferation and apoptosis of human synovial MH7A cells; a comparison with methotrexate. Mol. Med. Reports 15: 4398-4404, 2017.
• Isaka S, Someya A, Nakamura S, Naito K, Nozawa M, Inoue N, Sugihara F, Nagaoka I, Kaneko K: Evaluation of the effect of oral administration of collagen peptides on an experimental rat osteoarthritis model. Exp Ther Med 13: 2699-2706, 2017.
• Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K: Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model. Exp Ther Med13: 2969-2974, 2017.

2016

• Someya A, Ikegami T, Sakamoto K, Nagaoka I: Glucosamine downregulates the IL-1ß-Induced expression of proinflammatory cytokine genes in human synovial MH7A cells by O-GlcNAc modification-dependent and -independent mechanisms. PLoS One 11: e0165158, 2016.
• Miyamoto M, Takano M, Aoyama T, Soyama H, Kato M, Yoshikawa T, Shibutani T, Matsuura H, Goto T, Sasa H, Nagaoka I, Furuya K: Is modified radical hysterectomy needed for patients with clinical stage I/II endometrial cancers? A historical control study. Oncology 90: 179-185, 2016.
• Inoue S, Nakajima S, Endo M, Nagaoka I: Correlation between lipid peroxide concentration in sserum and intake pattern with a focus on lipid, copper, histidine, and folic acid. J Jpn Mibyo System Association 22: 15-28, 2016.
• Tomonaga A, Fukagawa M, Ikeda H, Hori T, Ohkawara M, Nagaoka I: Evaluation of the effect of the administration of an N-acetyl-glucosamine-containing green tea supplement on biomarkers for cartilage metabolism in healthy individuals without symptoms of arthritis: a randomized double-blind placebo-controlled clinical study. Functional Foods in Health and Disease 6: 788-808, 2016.
• Tomonaga A, Watanabe K, Fukagawa M, Suzuki A, Kurokawa M, Nagaoka I: Evaluation of the effect of N-acetyl-glucosamine administration on biomarkers for cartilage metabolism in healthy individuals without symptoms of arthritis: a randomized double-blind placebo-controlled clinical study. Exp Ther Med 12: 1481-1489, 2016.
• Tada H, Shimizu T, Nagaoka I, Takada H: Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells. Biomed Res 37: 199-205, 2016.
• Iba T, Hamakubo T, Nagaoka I, Sato K, Thachil J: Physiological levels of pentraxin 3 and albumin attenuate vascular endothelial cell damage Induced by histone H3 in vitro. Microcirculation 23: 240-247, 2016.
• Komatsu J, Nagura N, Iwase H, Igarashi M, Ohbayashi O, Nagaoka I, Kaneko K: Effect of intermittent teriparatide (human parathyroid hormone 1-34) on the mechanical and histological changes in the bone grafted with β-tricalcium phosphate using a rabbit bone defect model. Exp Ther Med 2016 (in press)
• Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I: Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice. Int Immunol 28: 245–253, 2016.
• Murakami T, Hu Z, Tamura H, Nagaoka I: Release mechanism of high mobility group nucleosome binding protein 1 from lipopolysaccharide-stimulated macrophages. Mol Med Rep 13: 3115-3120, 2016.
• Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I: Human host defense cathelicidin peptide LL-37 enhances the lipopolysaccharide uptake by liver sinusoidal endothelial cells without cell activation. J Immunol 196: 1338-1347, 2016.

2015

• Iba T, Hashiguchi N, Nagaoka I, Tabe Y, Kadota K, Sato K: Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction. Intensive Care Medicine Experimental 3: 36, 2015, DOI 10.1186/s40635-015-0072-z
• Hosoda H, Tamura H, Nagaoka I: Evaluation of the lipopolysaccharide-induced transcription of human TREM-1 gene in vitamin D3-matured THP-1 macrophage-like cells. Int J Mol Med 36: 1300-1310, 2015.
• Miyamoto M, Takano M, Iwaya K, Shinomiya N, Goto T, Kato M, Suzuki A, Aoyama T, Hirata J, Nagaoka I, Tsuda H, Furuya K: High-temperature-required protein A2 as a predictive marker for response to chemotherapy and prognosis in patients with high-grade serous ovarian cancers. Br J Cancer 112: 739-744, 2015.
• Nagura N, Komatsu J, Iwase H, Hosoda H, Ohbayashi O, Nagaoka I, Kaneko K: Effects of the combination of vitamin K and teriparatide on the bone metabolism in ovariectomized rats. Biomed Reports 3: 295-300, 2015.