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Prof. Isao NAGAOKA, M.D., Ph.D.
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  • M.D. : Juntendo University, School of Medicine, Japan (1979)
  • Ph.D. (Biochemistry) : Juntendo University, School of
    Medicine, Japan (1983)

Current Research Projects

  1. Functional and transcriptional analyses of antibacterial peptides
  2. Protective action of antibacterial peptides on endotoxin shock
  3. Anti-inflammatory action of glucosamine

Publications

  • Niyonsaba F, Nagaoka I, Ogawa H: Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit Rev Immunol 26: 545-576, 2006.
  • Nagaoka I, Tamura H, Hirata M: An Antimicrobial Cathelicidin Peptide, Human CAP18/LL-37, Suppresses Neutrophil Apoptosis via the Activation of Formyl-Peptide Receptor-Like 1 and P2X7. J Immnol 176: 3044-3052, 2006.
  • Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M: Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions. Inflamm Res 54: 66-73, 2005.
  • Nagaoka I, Yomogida S, Tamura H, Hirata M: Antibacterial cathelicidin peptide CAP11 inhibits the lipopolysaccharide (LPS)-induced suppression of neutrophil apoptosis by blocking the binding of LPS to target cells. Inflamm Res 53: 609-622, 2004.
  • Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Tanaka S, Heumann D: Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol 9: 972-982, 2002.
  • Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D: Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-a by blocking the binding of LPS to CD14+ cells. J Immunol 167: 3329-38, 2001.