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Akimasa SOMEYA, Ph.D.
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  • B.Pharm. : Faculty of Pharmacy, Tokyo University
    of Pharmacy and Life Science, Japan (1981)
  • M.Pharm. : Graduate School of Pharmacy, Tokyo
    University of Pharmacy and Life Science, Japan (1983)
  • Ph.D. (Biochemistry) : Juntendo University,
    School of Medicine, Japan

Current Research Projects

  1. Phagocyte functions mediated by small GTP-binding proteins
  2. Activation mechanisms of superoxide generating NADPH oxidase

Publications

  • Murakami T, Yomogida S, Someya A, Kuwahara-Arai K, Tamura H, Nagaoka I: Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. FEBS Lett 581: 140-144, 2007.
  • Someya A, Moss J, Nagaoka I: Involvement of a guanine nucleotide-exchange protein, ARF-GEP100/BRAG2a in the apoptotic cell death of monocytic phagocytes. J Leukoc Biol 80: 915-921, 2006.
  • Hiroi T, Someya A, Thompson W, Moss J, Vaughan M: GEP100/BRAG2, activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin. Proc Natl Acad Sci USA 103: 10672-10677, 2006.
  • Someya A, Sata M, Takeda K, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M : ARF-GEP100, a guanine nucleotide-exchange protein for ADP-ribosylation factor 6. Proc Natl Acad Sci U S A. 98: 2413-2418, 2001.