分野紹介

教授 大熊 泰之(おおくま やすゆき)

プロフィール

大学院

専門分野 臨床医学(神経学、脳神経内科)
研究キーワード 神経内科学
パーキンソン病
臨床神経生理
授業科目区分 専門科目
博士前期課程
授業科目
演習、特別研究

学部(保健看護学部)

所属 教養基礎
授業科目 臨床医学Ⅲ、教養ゼミナール

学位

医学博士 1996年

pagetop

研究テーマ

  • パーキンソン病の病態解明・治療
  • パーキンソン病関連疾患の歩行障害
  • 臨床神経生理学(脳波・筋電図)

最近の活動と研究(過去5年間)

主な社会活動

  1. Treasurer, Asian & Oceanian Section of International Parkinson and MDS (2015-2019)
  2. 静岡県指定難病審査会委員(2000-現在)
  3. 日本神経学会パーキンソン病治療ガイドライン(初版)作成委員(2000-2002)
  4. 日本神経学会代議員・指導医

著書

  1. Okuma Y, Mizuno Y. Electrophysiology and other auxiliary investigations. In Cognitive impairment and dementia in Parkinson’s disease. 2nd edition. Ed. by Emre M. Oxford University Press, Oxford, UK, 153-162, 2015
  2. Okuma Y, Mizuno Y. Electrophysiology and other auxiliary investigations. In Dementia in Parkinson’s Disease. Ed. by Emre M. Oxford University Press, Oxford, UK, 2010
  3. 大熊泰之.第3章 症候から鑑別診断へ.てんかん.神経内科ハンドブック第5版,水野美邦編集,医学書院,東京,2016
  4. 大熊泰之.第4章 神経学的検査法.生理学的検査.神経内科ハンドブック第5版,水野美邦編集,医学書院,東京,2016
  5. 大熊泰之.第5章 診断と治療.脊椎疾患.神経内科ハンドブック第5版,水野美邦編集,医学書院,東京,2016
  6. 大熊泰之.転倒(歩行障害).パーキンソン病・パーキンソン症候群の在宅ケア.佐藤 猛,服部信孝,村田美穂編,中央法規,東京,2016, pp132-138.
  7. 大熊泰之.セクションIII.神経症候の診かた. 23.異常姿勢の診かた.臨床神経内科学改訂6版.平山恵造監修,廣瀬源二郎,田代邦雄,葛原茂樹編集,南山堂,東京,2016, pp237-241
  8. 大熊泰之.セクションIII.神経症候の診かた. 24.起立・歩行障害の診かた.臨床神経内科学改訂6版.平山恵造監修,廣瀬源二郎,田代邦雄,葛原茂樹編集,南山堂,東京,2016, pp242-250
  9. 河尻澄宏,大熊泰之.進行性核上性麻痺,皮質基底核変性症.神経疾患最新の治療2015-2017. p156-158. 南江堂 2015.
  10. 大熊泰之.進行期治療をどうするか?(運動合併症の対処,姿勢異常,すくみ,転倒への対処).インフォームドコンセントのための図説シリーズ:パーキンソン病.武田篤編,医薬ジャーナル社,2013, pp64-73.
  11. 大熊泰之.パーキンソン病のすくみ足ってどんな症状なの? jmedあなたも名医.ここを押さえる,パーキンソン病診療.服部信孝編,日本医事新報社2012. P45-50.
  12. 大熊泰之.パーキンソン病治療における抗コリン薬の位置づけは? jmedあなたも名医.ここを押さえる,パーキンソン病診療.日本医事新報社2012. P73-76.
  13. 塩月寛美,大熊泰之.変性疾患 ?パーキンソン病を中心として?.神経救急・集中治療ハンドブック2012
  14. 大垣光太郎,大熊泰之.歩行障害 ?責任病巣はどこか?.すべての内科医が知っておきたい神経疾患の診かた考え方とその対応.大生定義編,羊土社 2012 pp77
  15. 大熊泰之.パーキンソン病の転倒防止と寝たきり予防.GP・レジデントのためのパーキンソン病テキストブック.山本光利編,アルタ出版 2012. p218-227

原著論文

  1. Kawajiri S, 他5名, Okuma Y. A case of painless legs and moving toes syndrome in Parkinson’s disease responsive to dopaminergic therapy. Case Rep Neurol Med. 2016:6829410, 2016
  2. Sasaki F, 他6名, Okuma Y. Occipital lobe seizures and subcortical T2 and T2* hypointensity associated with nonketotic hyperglycemia: a case report. J Med Case Rep. 10:228, 2016
  3. Noda K, 他2名, Okuma Y, Yamamoto T. Hemichorea improvement following endarterectomy for internal carotid artery stenosis. J Neurol Sci 371:45-47, 2016
  4. Noda K. Hattori, N, Okuma Y. Re-emergent tremor in a patient with Parkinson’s disease. BMJ Case Rep 2016, bcr2016216436, 2016
  5. Yoritaka A, 他11名, Okuma Y, 他9名. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurology 16:66, 2016
  6. Tomizawa Y, 他11名, Okuma Y. Tumefactive demyelinating brain lesions with multiple closed-ring enhancement in the course of neuromyelitis optica. J Neurol Sci 361:49-51, 2016
  7. Noda K, 他5名, Okuma Y. ?Delayed chorea after recovery from severe akinetic-rigid parkinsonism caused by extrapontine myelinolysis. J Neurol Sci 358:498-500, 2015
  8. Noda K, 他6名, Okuma Y. Middle cerebral artery occlusion presenting as upper limb monochorea. J Stroke Cerebrovascular Dis 24:e-291-293, 2015
  9. Murata M, 他5名; Japan zonisamide on PD Study Group (Y. Okuma is a member of this study group). Zonisamide improves wearing-off in Parkinson’s disease: A randomized, double-blind study. Mov Disord 30:1343-1350, 2015
  10. Tanaka R, Yamashiro K, Okuma Y, 他6名. Effects of pioglitazone for secondary stroke prevention in patients with impaired glucose tolerance and newly diagnosed diabetes: The J-SPIRIT study. J Atheroscler Thromb. 22:1305-1316, 2015
  11. Noda K, 他3名, Okuma Y. Pisa syndrome in progreesive supranuclear palsy: a case report. Parkinsonism Relat Disord 21:1115-1116, 2015
  12. Fujimaki M, 他6名, Okuma Y. Lymphomatoid granulomatosis with central nervous system involvement successfully treated with cyclophosphamide, high-dose cytarabin, dexamethasone, etoposide, and rituximab (CHASER therapy) : Case study. CNS Neuroscience & Therapeutics 21:610-612, 2015
  13. Tomizawa T, 他4名, Okuma Y. A patient with the GLA p.E66Q mutation exhibiting vascular parkinsonism and bilateral pulvinar lesions. Intern Med 54:2503-2506, 2015
  14. Tomizawa T, 他8名, Okuma Y. The diagnostic utility of splenial lesion in a case of Legionnaires’ disease due to Legionella pneumophila serogroup 2. Intern Med 54:3079-3082, 2015
  15. Fukae J, 他7名, Okuma Y, 他3名. Utility of the Japanese version of the 9-item wearing-off questionnaire. Clin Neurol Neurosurgery 134:110?115, 2015
  16. Tomizawa Y, 他6名, Okuma Y. Two cases of steroid responsive encephalomyelitis with reversible diffuse cerebral arterial stenosis: A case report and review of the literature. Clin Exper Neuroimmunol 6: 89?92, 2015
  17. Kawajiri S, 他5名, Okuma Y. Low dose of clonazepam is effective in the treatment of Painless legs and moving toes syndrome: A case report. ?Case Rep Neurol 7:59-62, 2015.
  18. Noda K, Hattori N, Okuma Y. Hemiballism with leg predominance caused by contralateral subthalamic haemorrhage.BMJ Case Rep. 2015 bcr-2014-208525
  19. Miura Y, 他6名, for the CNTN1-CIDP Study Group (Okuma Y. is a member of this study group). Contactin-1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia. Brain 138:1484-91, 2015
  20. Okuma Y. A patient-invented maneuver to alleviate freezing of gait using a foot loop band. Case Rep Neurol 6:256?258, 2014
  21. Yamashiro K, Tanaka R, Okuma Y, 他5名. Cerebral microbleeds are associated with worse cognitive function in the nondemented elderly with small vessel disease. Cerebrovasc Dis Extra 4:212?220, 2014
  22. Yoneyama M, Okuma Y, 他3名. Human turnover dynamics during sleep: statistical behavior and its modeling. ?Phys Rev E Stat Nonlin Soft Matter Phys. 89:032721, 2014
  23. Noda K, Hattori N, Okuma Y. Primary central nervous system lymphoma presenting as choreoathetosis. BMJ Case Rep 2014, bcr-2013-203353
  24. Yamashiro K, Tanaka R, Okuma Y, 他3名. Associations of durations of antiplatelet use and vascular risk factors with the presence of cerebral microbleeds. J Stroke Cerebrovasc Dis 23:433-440, 2014
  25. Oji Y, 他3名, Okuma Y, Yamashiro K. Spontaneous spinal subarachnoid hemorrhage after severe coughing: a case report. J Med Case Reports 7;274, 2013
  26. Mori A, 他2名, Okuma Y, 他7名. Bilateral facial nerve palsy due to otitis media associated with myeloperoxidase-antineutrophil cytoplasmic antibody. Am J Med Sci 346;240-243, 2013
  27. Fuse A, 他5名, Okuma Y. Reversible focal cerebral cortical lesions in a patient with heat stroke. Intern Med 52;377-380, 2013
  28. Yoneyama M, Mitoma H, Okuma Y. Accelerometry-based long-term monitoring of movement disorders: from diurnal gait behavior to nocturnal bed mobility. J Mechanics Med Biol 13; 1350041, 2013
  29. Utsumi H, Okuma Y, 他11名. Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson’s disease. Intern Med 52:325-332, 2013
  30. Utsumi H, 他5名, Okuma Y, 他3名, Mitoma H. Quantitative assessment of gait bradykinesia in Parkinson’s disease using a portable gait rhythmogram. Acta Medica Okayama 66:31-40, 2012
  31. Ogaki K, 他8名, Okuma Y. Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis. Neurologist 18:76-79, 2012(*corresponding author)
  32. Terashi H, 他3名, Okuma Y, Yoneyama M, Mitoma H. Deficits in scaling of gait force and cycle in parkinsonian gait identified by long-term monitoring of acceleration with the portable gait rhythmogram. ISRN Neurology Volume 2012, Article ID 306816, 8 pages
  33. Utsumi H, 他3名, Okuma Y, Yoneyama M, Mitoma H. How far do the complaints of patients with Parkinson’s disease reflect motor fluctuation? Quantitative analysis using a portable gait ryhthmogram. ISRN Neurology Volume 2012, Article ID

研究発表

  1. Okuma Y. Invited speaker. History and current status of gait disorders in Japan. 1st International conference of Korean movement disorders society, Jeju, Oct 28-30, 2016
  2. Okuma Y. Invited speaker. Freezing of gait and falls in Parkinson’s disease. 2016 Annual meeting of the Taiwan movement society, Taipei, Oct 22-23, 2016
  3. Okuma Y, Mitoma H, Yoneyama M. Identifying freezing of gait and falls in Parkinson's disease patients using a body-worn sensor. 15th Asian and Oceanian congress of Neurology, Kuala Lumpur, August 18-21, 2016
  4. Okuma Y, Mitoma H, Yoneyama M. Identifying freezing of gait and falls in Parkinson's disease patients using a body-worn sensor. 20th International Parkinson’s disease and movement disorders congress, Berlin, June 19-23, 2016
  5. Okuma Y, Mitoma H, Yoneyama M. Detection and quantification of freezing of gait and falls in Parkinson's disease patients using a body-worn sensor. 22thWorld congress of Neurology, Santiago, Nov 1, 2015
  6. Okuma Y, Mitoma H, Yoneyama M. Detection and quantification of freezing of gait and falls in Parkinson's disease patients using a wearable motion sensor. 19th International Parkinson’s disease and movement disorders congress, San Diego, June, 2015
  7. Okuma Y. Symposium speaker. Physiological and clinical dynamics of freezing of gait and falls in Parkinson’s disease. 4th Asian & Oceanian Parkinson’s disease and movement disorders congress. Pattaya Thailand, Nov 28-30, 2014
  8. Okuma Y, Mitoma H, Yoneyama M. Detecting freezing of gait and falls using wearable motion recorder in Parkinson's disease patients. 18th International Parkinson’s disease and movement disorders congress, Stockholm, June8-12, 2014
  9. Okuma Y. Symposium speaker. Freezing of gait in Parkinson’s disease. 2nd Joint World Congress of ISPGR and Gait and Mental function. Akita, Japan, June 22-26, 2013
  10. Okuma Y. Symposium speaker. Freezing of gait and falls in Parkinson’s disease patients. 9th international congress on mental disorders & other non-motor features in Parkinson’s disease and related disorders, Seoul, South Korea, April 18-21, 2013
  11. Okuma Y. Symposium speaker. Clinical spectrum and a practical approach to freezing of gait (FOG) in PD. 6th Annual scientific meeting of the Association of Srilankan Neurologists(ASN). Nov 18, 2012
  12. Okuma Y, Mitoma H, Yoneyama M. Detecting freezing of gait and falls using motion recorder in Parkinson’s disease patients during everyday activities. 1st Joint World Congress of ISPGR and Gait & Mental Function. Trondheim, Norway, June 24-28, 2012

研究助成等

  1. 重度嗅覚障害を呈するパーキンソン病を対象としたドネペジルの予後改善効果に関する研究(分担研究者). 厚生労働科学研究費補助金→国立研究開発法人日本医療研究開発機構(AMED) 臨床研究・治験推進研究事業 2012年度-2016年度.?
  2. 独立成分解析による脳死判定のための脳波信号処理(分担研究者). 日本学術振興会科学研究費補助金. 基盤研究(B) 2000年度-2001年度.
  3. A型ボツリヌス菌毒素の筋肉内限局投与法による不随意運動の治療(研究代表者). 日本学術振興会科学研究費補助金. 奨励研究(A) 1991年度.