Cervantes F, Ross DM, Radinoff A, Palandri F, Myasnikov A, Vannucchi AM, Zachee P, Gisslinger H, Komatsu N, Foltz L, Mannelli F, Passamonti F, Gilotti G, Sadek I, Tiwari R, Zor E, Al-Ali HK, Efficacy and safety of a novel dosing strategy for ruxolitinib in the treatment of patients with myelofibrosis and anemia: the REALISE phase 2 study, Leukemia, 2021 Dec; 35(12): 3455-3465.
Edahiro Y, Yasuda H, Gotoh A, Morishita S, Suzuki T, Takeda J, Ando J, Tsutsui M, Itakura A, Komatsu N, Interferon therapy for pregnant patients with essential thrombocythemia in Japan, Int J Hematol, 2021 Jan; 113(1): 106-111.
Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N, Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma, Molecular Therapy, in press, 2021.
Ikeda S, Tsunoda S, Koyama D, Suzuki M, Sukegawa M, Misawa K, Hojo H, Zhu X, Utano K, Ohta M, Femoral marrow MRI is a non-invasive, non-irradiated and useful tool for detecting bone marrow involvement in non-Hodgkin lymphoma, J Clin Exp Hematop, 2021 Jun; 61(2): 78-84.
Inano T, Araki M, Morishita S, Imai M, Kihara Y, Okuda M, Yang Y, Ito M, Osaga S, Mano M, Edahiro Y, Ochiai T, Misawa K, Fukuda Y, Ando J, Komatsu N, Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia, Scientific Reports, 2021 Sep; 11(1): 17702.
Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M, iPSC-derived neoantigen-specific cytotoxic T-lymphocyte therapy for Ewing sarcoma, Cancer Immunology Research, 2021; 9(10): 1175-1186.
Kinoshita S, Ando M, Ando J, Ishii M, Furukawa Y, Tomita O, Shirane S, hito Kishita Y, Yatsuka Y, Eguchi H, Okazaki Y, Komatsu N, Trigenic ADH5 / ALDH2 / ADGRV1 mutations in myelodysplasia with Usher syndrome, Heliyon, 2021; 7(8): e07804.
Komatsu N, Arita K, Mitsui H, Nemoto T, Hanaki K, Efficacy and safety of ferric citrate hydrate compared with sodium ferrous citrate in Japanese patients with iron deficiency anemia: a randomized, double-blind, phase 3 non-inferiority study, Int J Hematol, 2021 Jul; 114(1): 8-17.
Morishita S, Yasuda H, Yamawaki S, Kawaji H, Itoh M, Edahiro Y, Imai M, Kogo Y, Tsuneda S, Ohsaka A, Hayashizaki Y, Ito M, Araki M, Komatsu N, CREB3L1 overexpression as a potential diagnostic marker of Philadelphia chromosome-negative myeloproliferative neoplasms, Cancer Sci, 2021 Feb; 112(2): 884-892.
Morishita S, Ochiai T, Misawa K, Osaga S, Inano T, Fukuda Y, Edahiro Y, Ohsaka A, Araki M, Komatsu N, Clinical impacts of the mutational spectrum in Japanese patients with primary myelofibrosis, eron therapy for pregnant patients with essential thrombocythemia in Japan, Int J Hematol, 2021 Apr; 113(4): 500-507.
Ochi Y, Yoshida K, Huang YJ, Kuo MC, Nannya Y, Sasaki K, Mitani K, Hosoya N, Hiramoto N, Ishikawa T, Branford S, Shanmuganathan N, Ohyashiki K, Takahashi N, Takaku T, Tsuchiya S, Kanemura N, Nakamura N, Ueda Y, Yoshihara S, Bera R, Shiozawa Y, Zhao L, Takeda J, Watatani Y, Okuda R, Makishima H, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Takaori-Kondo A, Miyano S, Ogawa S, Shih LY, Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia, Nat Commun, 2021 May 14; 12(1): 2833.
Ohara K, Kinoshita S, Ando J, Azusawa Y, Ishii M, Harada S, Mitsuishi Y, Asao T, Tajima K, Yamamoto T, Takahashi F, Komatsu N, Takahashi K, Ando M, SCLC-J1, a novel small cell lung cancer cell line, Biochem Biophys Rep, 2021 Jul; 27: 101089.
Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Uemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki Mi, Takizawa H, Fukuyama T, Lamagna C, Masuda E, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T, Eliminating chronic myeloid leukemia stem cells by IRAK 1/4 inhibitors, Nature Communications, in press, 2021
Ugawa M, Kawamura Y, Toda K, Teranishi K, Morita H, Adachi H, Tamoto R, Nomaru H, Nakagawa K, Sugimoto K, Borisova E, An Y, Konishi Y, Tabata S, Morishita S, Imai M, Takaku T, Araki M, Komatsu N, Hayashi Y, Sato I, Horisaki R, Noji H, Ota S, In silico-labeled ghost cytometry Elife, 2021 Dec; 10: e67660.
Watanabe N, Gao S, Wu Z, Batchu S, Kajigaya S, Diamond C, Alemu L, Raffo DQ, Hoffmann P, Stone D, Ombrello AK, Young NS. Analysis of deficiency of adenosine deaminase 2 pathogenesis based on single-cell RNA sequencing of monocytes, J Leukoc Biol. 2021 Sep; 110(3): 409-424.
Yamauchi T, Yoshida C, Usuki K, Takada S, Matsumura I, Dobashi N, Miyazaki Y, Miyamoto T, Iida H, Asou N, Kuroda J, Ichikawa S, Komatsu N, Mendes W, Honda H, Okubo S, Kurokawa M, Jiang Q, Wei A, Ishizawa K, Venetoclax plus low-dose cytarabine in Japanese patients with untreated acute myeloid leukaemia ineligible for intensive chemotherapy, Jpn J Clin Oncol, 2021 Aug; 51(9): 1372-1382.
Yasui H, Kobayashi M, Sato K, Kondoh K, Ishida T, Kaito Y, Tamura H, Handa H, Tsukune Y, Sasaki M, Komatsu N, Tanaka N, Tanaka J, Kizaki M, Kawamata T, Circulating cell-free DNA in the peripheral blood plasma of patients is an informative biomarker for multiple myeloma relapse, Int J Clin Oncol, 2021 Nov; 26(11): 2142-2150.
英文総説
Yasuda H, Yasuda M, Komatsu N, Chemotherapy for non-Hodgkin lymphoma in the hemodialysis patient: A comprehensive review, Cancer Sci, 2021 Jul; 112(7): 2607-2624.
英文著書
Ando M, Kinoshita S, Furukawa Y, Ando J, Nakauchi H, Brenner MK: Advances in stem cell biology, volume 12, Molecular Players in iPSC Technology, Elsevier, 2021, Chapter 3, Improving the safety of iPSC-derived T cell therapy, 95-115.
英文症例報告
Ando J, Ueno Y, Yasuda H, Ando M, Edahiro Y, Honda T, Takanashi M, Taniguchi D, Hattori N, Komatsu N, Radiation-Induced Myopathy Developing in a Hodgkin Lymphoma Patient: An Autopsy Case with Systemic Muscle Sampling, Case Rep Oncol, 2021 Mar; 14(1): 338-342.
Edahiro Y, Takaku T, Suzuki M, Fukuda Y, Harada S, Kinoshita S, Inano T, Shirane S, Hamano Y, Kondo A, Komatsu N, Intravascular large B-cell lymphoma as a recurrence of primary central nervous system lymphoma after chemotherapy: A case report, Leuk Res Rep, 2021 May; 15: 100249.
Fukumura Y, Taniguchi G, Koyanagi A, Horiuchi Y, Ochiai T, Tabe Y, Sano K, Maimaitiaili Y, Otsuji N, Ashizawa K, Yao T, A Case of Untreated Myeloid Sarcoma of the Pancreas Head Region: Diagnostic Process of AML Subtyping in an Autoptic Case, Case Rep Pathol, 2021
Furukawa Y, Ando J, Ando M, Kinoshita S, Edahiro Y, Furuta T, Ohshima K, Komatsu N, Long-term spontaneous regression of Stage IV diffuse large B-cell lymphoma, J Clin Exp Hematop, 2021 Sep; 61(3): 168-172.
Furukawa Y, Ando M, Azusawa Y, Kinoshita S, Harada S, Ochiai T, Honda T, Sugimoto K, Tabe Y, Komatsu N, Ando J, Persistent immune thrombocytopaenic purpura associated with SARS-CoV-2 infection, EJHaem, 2021 May; 2(3), 530-533.
Harada S, Ando J, Ando M, Azusawa Y, Ochiai T, Hashimoto Y, Hirasawa Y, Komatsu N, Sarcoma-like appearance but pathologic Hodgkin lymphoma, Int J Hematol, 2021 Jul; 114(1): 1-2.
Harada S, Ando J, Ando M, Nitta H, Inano T, Hirasawa Y, Furukawa Y, Kinoshita S, Kondo A, Ohshima K, Komatsu N, High-grade Primary Central Nervous System Lymphomatoid Granulomatosis: Successful Rituximab Monotherapy, Intern Med, 2021 Dec; 60(23): 3795-3799.
Haraguchi M, Harada N, Watanabe J, Yoshikawa H, Shirai Y, Komura M, Koyama M, Ito J, Tsukune Y, Horimoto Y, Hayashi T, Nagaoka T, Uekusa T, Takahashi K, Disseminated nontuberculous mycobacteriosis and fungemia after second delivery in a patient with MonoMAC syndrome/GATA2 mutation: a case report, BMC Infect Dis, 2021; 21: 502.
Iizuka H, Harada S, Iwao N, Koike M, Noguchi M, Primary Skeletal Muscle Peripheral T-cell Lymphoma: An Autopsy Case Report and Review of the Literature,Internal medicine, 2021; 60(20): 3309-3315.
Iizuka H, Mori Y, Iwao N, Koike M, Noguchi M, Hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus-positive diffuse large B-cell lymphoma, NOS of bone marrow-liver-spleen type: an autopsy case report, Journal of clinical and experimental hematopathology, 2021 Jun; 61(2): 102-108.
Iizuka H, Mori Y, Fukuda Y, Iwao N, Koike M, Noguchi M, Two autopsy cases of pulmonary leukemic infiltration mimicking severe pneumonia in patients with acute myeloid leukemia, Leukemia Research Reports, 2021; 16: 100269.
Kinoshita S, Ando J, Ando M, Komatsu N, Primary Lymphoma of the Pericardium, Intern Med, 2021 Dec; 60(24): 4005-4006.
Mori T, Abe H, Yoshida M, Tsukune Y, Yahata Y, Takaku T, Ando J, Ando M, Torii S, Sasaki M, Immunohistochemical detection of aflatoxin in lesions of aflatoxin-producing Aspergillus flavus infection, Medical Mycology Journal, 2021; 62(3): 47-52.
Takahashi M, Makino S, Iizuka H, Noguchi M, Yoshida K, Chronic active Epstein-Barr virus associated secondary hemophagocytic lymphohistiocytosis in pregnancy: a case report, lBMC Pregnancy Childbirth, 2021; 21: 681.
Sano M, Iseki T, Sasaki M, Tsukune Y, Yasuda H, Kanazawa K, Arakawa A, Yokoyama K, Komatsu N, Hattori N, Nishioka K, Improvement in the Symptoms and VEGF Levels after Resection of an Extrame Dullary Spinal Tumor and Additional Chemotherapy in a Patient with Multiple Myeloma Complicated with POEMS Syndrome, Intern Med, 2021; 60: 3625-3630.
Sekiguchi Y, Nishitani M, Takizawa H, Iizuka H, Mitsumori T, Noguchi M, Sawada T, Yoshikawa S, Okubo T, Okubo M, Yoshikawa S, A Case of CCR4-Positive, Localized Primary ATLL of the Bone, Ann Case Report, 2021; 6: 650.
Shirane S, Watanabe D, Sekiya N, Horiguchi S, Najima Y, Paraplegia via hematogenous dissemination of Cunninghamella elegans (mucormycosis) after hematopoietic stem cell transplantation, Int J Infect Dis, 2021 Dec; 113: 210-212.
Takahashi M, Makino S, Iizuka H, Noguchi M, Yoshida K, Chronic active Epstein-Barr virus associated secondary hemophagocytic lymphohistiocytosis in pregnancy: a case report, lBMC Pregnancy Childbirth, 2021; 21: 681.
Yamashita Y, Takahashi Y, Tsunemi T, Shirane S, Nakazato-Taniguchi T, Taniguchi D, Takanashi M, Sasaki M, Komatsu N, Hattori N, Systemic sclerosis precedes POEMS syndrome, Can J Neurol Sci, 2021 May; 48(3): 446-449.
Yasuda H, Morishita S, Mori Y, Tsukune Y, Inano T, Harada S, Komatsu N, JAK2/CALR/SF3B1 triple-mutated myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis evolving to myelofibrosis and SF3B1 single-mutated acute myeloid leukemia: evidence of a pre-JAK2 clone, Leuk Res, 2021 Jan; 100: 106496.
Yasuda H, Tsukune Y, Tadaaki Inano, Yosuke Mori, Yasunori Ota, Komatsu N, Successful long-term ibrutinib treatment in a hemodialysis patient with leukemic non-nodal mantle cell lymphoma, Clin Lymphoma Myeloma Leuk, 2021 Feb; 21(2): e176-e178.
Yasuda H, Mori Y, Chiba A, Bai J, Murayama G, Matsushita Y, Miyake S, Komatsu N, Resolution of one-year persisting COVID-19 pneumonia and development of immune thrombocytopenia in a follicular lymphoma patient with preceding rituximab maintenance therapy: a follow-up report and literature review of cases with prolonged infections, Clin Lymphoma Myeloma Leuk, 2021 Oct; 21(10): e810-e816.
国際学会発表
Ando M, Ando J, Ishii M, Honda T, Kinoshita S, Furukawa Y, Masuda A, Kitade M, Terao Y and Nakauchi H, iPSC-derived "off-the-shelf" CTL therapy for cervical cancers.
ISSCR International Symposium Tokyo 2021, Tokyo, Japan, 29th Oct, 2021 (oral presentation)
Ishii M, Ando J, Toyota T, Ohara K, Nakauchi H, Ando M, iPSC-derived neoantigen-specific cytotoxic T lymphocyte therapy for Ewing sarcoma, ISSCR 2021, Virtual (poster), 21 June - 26 June, 2021
Mesa RA, Komatsu N, Gill H, Jin J, Lee SE, Hou HA, Sato T, Qin A, Urbanski R, Shih W, Zagrijtschuk O, Zimmerman C, Verstovsek S, Surpass-ET Trial: A Phase 3, Open-Label, Multicenter, Randomized, Active-Controlled Study to Assess Pharmacokinetics and Compare the EJcacy, Safety, and Tolerability of P1101 Vs Anagrelide As Second Line Therapy for Essential Thrombocythemia 63nd ASH, December 11, 2021
Sekiguchi Y, Iizuka H, Takizawa H, Mitsumori Tet, al, Use of Ibrutinib in 10 Patients with Treatment-Naïve or Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in Real-World Clinical Practice -A Report from a Single Medical Institution, 癌と化学療法, 2021 Jul; 48(7): 921-926.
Sekiguchi Y, Nishitani M, Takizawa H, Iizuka H, Mitsumori T, et al, Low-Risk Essential Thrombocythemia Who Presented with Recurrent Episodes of Cerebral Hemorrhage during Pregnancy and Developed Cerebral Infarction during Puerperium, 癌と化学療法, 2021 May; 48(5): 725-730.
Hiromi Watari, Hiromu Kageyama, Hiroya Nakajia, Kako Onodera, Nami Masubuchi, Takumi Oshiro, Takashi Matui, Yoshio Kodera, Tomohisa Ogawa, Makoto Hirayama, Kanji Hori, Takeshi Yokoyama, Norio Komatsu, Marito Araki, Yoshikazu Tanaka, Ryuichi Sakai, Marine sponge lectin reveals the mechanism of sugar-chain mediated activation of MPL , 第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)~25日(土)
Kaoko Sakai, Hideyuki Nakazawa, Makoto Hirokawa, Naohito Fujishima, Yuji Yonemura, Shunya Arai, Hideo Harigae, Akira Matsuda, Norio Komatsu, Kaoru Tohyama, Shinji Nakao, Mineo Kurokawa, Kinuko Mitani, Fumihiro Ishida, One third of the patients with acquired chronic PRCA show macrocytic anemia: data from PRCA2016, 第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)~25日(土)
Kazuya Sugimoto, Miki Ando, Jun Ando, Midori Ishii, Yoko Azusawa, Yoshiki Furukawa, Shintaro Kinoshita, Tadahiro Honda, Sakiko Harada, Hiromitsu Nakauchi, Norio Komatsu, Development of iPSC-derived Tax-specific CTL therapy for adult T-cell leukemia/lymphoma, 第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)~25日(土)
Norio Komatsu, Terumi Baba, Manami Otsuka, Takafumi Akimoto, Jovelle Fernandez, Safety and efficacy of anagrelide from post-marketing surveillance data in Japan, 第83回日本血液学会学術集会, Web開催, 2021年9月23日(木・祝)~25日(土)