RESEARCH

Keywords

• Biology of Aging
• Cardiovascular Biology
• Regenerative Medicine
• Metabolic Disease
• Cellular Senescence

Main Research Topics and Interests

• The molecular mechanisms of age-associated disease (including cardiovascular and metabolic disease)
• The roles of cellular senescence in age-associated disease
• The development of senolytic treatment
• The development of regenerative therapy

Publications (in English)

• Original Articles: 149
• Review Articles: 33

Recent Main Publications

• Suda M, Minami T et al. Senolytic vaccination improves pathological aging. Nat Aging. 2021 (in press).
• Shimizu I, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab 2014; 20: 967-977.
• Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. Cell Metab. 2013; 18: 491-504.
• Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab. 2012; 15: 51-64.
• Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009; 15: 1082-1087.
• Minamino T and Komuro I. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Rev Cardiol 2008; 5: 637-648.
• Sano M, Minamino T*, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin J D, Zou Y and Komuro I. p53-induced Inhibition of hif-1 causes cardiac dysfunction during pressure overload. Nature 2007; 446: 444-448. (*Co-first author)
• More

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