Juntendo University, Tokyo, established in 1838.

Publication

2024

• Maehara Y, Takeda K, Tsuji-Yogo K, Morimoto K, Harada M, Kuriyama K, Hirota S, Yagita H, Okumura K, Uchida K. Blockade of CD80/CD86-CD28 co-stimulation augments the inhibitory function of peptide antigen-specific regulatory T cells. Biomed Res.2024;45(3):115-123. doi: 10.2220/biomedres.45.115. PMID: 38839354


• Matsumoto R, Enzhi Y, Takeda K, Morimoto K, Yogo K, Harada M, Tokushige K, Maehara Y, Hirota S, Kojima Y, Ito M, Sougawa N, Miyagawa S, Sawa Y, Okumura K, Uchida K. CD8(+) T cell-mediated rejection of allogenic human-induced pluripotent stem cell-derived cardiomyocyte sheets in human PBMC-transferred NOG MHC double knockout mice. J Heart Lung Transplant. 2024 Apr 22:S1053-2498(24)01564-X. doi: 10.1016/j.healun.2024.04.003. Online ahead of print. PMID: 38657776


• Hanzawa S, Sugiura M, Nakae S, Masuo M, Morita H, Matsumoto K, Takeda K, Okumura K, Nakamura M, Ohno T, Miyazaki Y. The Prostaglandin D2 Receptor CRTH2 Contributes to Airway Hyperresponsiveness during Airway Inflammation Induced by Sensitization without an Adjuvant in Mice. Int Arch Allergy Immunol. 2024 Apr 10:1-9. doi: 10.1159/000537840. Online ahead of print. PMID: 38599205


• Jo-Watanabe A, Inaba T, Osada T, Hashimoto R, Nishizawa T, Okuno T, Ihara S, Touhara K, Hattori N, Oh-Hora M, Nureki O, Yokomizo T. Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury. Nat Commun.2024 Feb 27;15(1):1530. doi: 10.1038/s41467-024-45579-3. PMID: 38413581

2023

• Cossu D, Tomizawa Y, Yokoyama K, Sakanishi T, Momotani E, Sechi LA, Hattori N. Mycobacterium avium subsp. paratuberculosis Antigens Elicit a Strong IgG4 Response in Patients with Multiple Sclerosis and Exacerbate Experimental Autoimmune Encephalomyelitis. Life (Basel). 2023 Jun 25;13(7):1437. doi: 10.3390/life13071437. PMID: 37511812


• Cossu D, Yokoyama K, Sakanishi T, Sechi LA, Hattori N. Bacillus Calmette-Guérin Tokyo-172 vaccine provides age-related neuroprotection in actively induced and spontaneous experimental autoimmune encephalomyelitis models. Clin Exp Immunol.2023 Apr 7;212(1):70-80. doi: 10.1093/cei/uxad015. PMID: 36745025


• Shigematsu M, Takeda K, Matsunaga S, Sendai Y, Matsuura N, Suzuki R, Azuma T, Sasaki H, Okumura K, Sekine H, Yajima Y, Ohno T. Subgingival titanium wire implantation induces weak inflammatory responses but does not promote substantial T cell activation. Dent Mater J. 2023 Sep 29;42(5):633-640. doi: 10.4012/dmj.2022-258. Epub 2023 Jul 7. PMID: 37423721


• Chen P, Yang W, Nagaoka K, Huang GL, Miyazaki T, Hong T, Li S, Igarashi K, Takeda K, Kakimi K, Kataoka K, Cabral H. An IL-12-Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors. Adv Sci (Weinh). 2023 Apr;10(10):e2205139. doi: 10.1002/advs.202205139. Epub 2023 Feb 5. PMID: 36739605


• Aida N, Takeda K, Nakae S, Saito H, Okumura K, Azuma T, Ohno T. IL-33 deficiency suppresses alveolar bone loss in a ligature-induced periodontitis model. Biomed Res. 2023;44(1):9-16. doi: 10.2220/biomedres.44.9. PMID: 36682799


• Hemmi J, Makino S, Yokoo T, Kano H, Asami Y, Takeda K, Suzuki Y, Kawai S, Nagaoka I, Sawaki K, Okumura K. Consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 augments serum antibody titers against seasonal influenza vaccine in healthy adults. Biosci Microbiota Food Health. 2023;42(1):73-80. doi: 10.12938/bmfh.2022-037. Epub 2022 Oct 13. PMID: 36660594


• Yokota M, Yoshino Y, Hosoi M, Hashimoto R, Kakuta S, Shiga T, Ishikawa KI, Okano H, Hattori N, Akamatsu W, Koike M. Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines. Front Cell Dev Biol. 2023 Sep 8;11:1171440. doi: 10.3389/fcell.2023.1171440. eCollection 2023. PMID: 37745304


• Hashimoto R, Koide H, Katoh Y. Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages. J Pharmacol Sci. 2023 Jan;151(1):46-53. doi: 10.1016/j.jphs.2022.11.003. Epub 2022 Nov 17. PMID: 36522122


• Hashimoto R, Koide H, Katoh Y. MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling. Cell Death Discov. 2023 Oct 13;9(1):374. doi: 10.1038/s41420-023-01674-w. PMID: 37833247

2022

• Nakajima H, Fujita S, Kakae M, Nagayasu K, Oh-Hora M, Shirakawa H, Kaneko S. Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes. Glia. 2022 Sep;70(9):1666-1680. doi: 10.1002/glia.24188. Epub 2022 May 4. PMID: 35506586


• Lu X, Oh-Hora M, Takeda K, Yamasaki S. Selective suppression of IL-10 transcription by calcineurin in dendritic cells through inactivation of CREB. Int Immunol. 2022 Mar 25;34(4):197-206. doi: 10.1093/intimm/dxab112. PMID: 34953165


• Cossu D, Yokoyama K, Sato S, Noda S, Sakanishi T, Sechi LA, Hattori N. Age related immune modulation of experimental autoimmune encephalomyelitis in PINK1 knockout mice. Front Immunol. 2022 Nov 17;13:1036680. doi: 10.3389/fimmu.2022.1036680. eCollection 2022. PMID: 36466826


• Kawanabe-Matsuda H, Takeda K, Nakamura M, Makino S, Karasaki T, Kakimi K, Nishimukai M, Ohno T, Omi J, Kano K, Uwamizu A, Yagita H, Boneca IG, Eberl G, Aoki J, Smyth MJ, Okumura K. Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy. Cancer Discov. 2022 May 2;12(5):1336-1355. doi: 10.1158/2159-8290.CD-21-0929. PMID: 35180303


• Yasuda T, Nishiki K, Hiraki Y, Kato H, Iwama M, Shiraishi O, Yasuda A, Shinkai M, Kimura Y, Sukegawa Y, Chiba Y, Imano M, Takeda K, Satou T, Shiozaki H, Nakamura Y. Phase II Adjuvant Cancer-specific Vaccine Therapy for Esophageal Cancer Patients Curatively Resected After Preoperative Therapy With Pathologically Positive Nodes; Possible Significance of Tumor Immune Microenvironment in its Clinical Effects. Ann Surg. 2022 Jan 1;275(1):e155-e162. doi: 10.1097/SLA.0000000000003880. PMID: 33055588


• Hashimoto R, Gupte SA. G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation. Vascul Pharmacol. 2022 Jun;144:106976. doi: 10.1016/j.vph.2022.106976. Epub 2022 Mar 7. PMID: 35272030


• Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S. Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2. EMBO J. 2022 Nov 17;41(22):e111476. doi: 10.15252/embj.2022111476. Epub 2022 Oct 11. PMID: 36394115

2021

• Cossu D, Yokoyama K, Sakanishi T, Kuwahara-Arai K, Momotani E, Hattori N. A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE. J Neuroimmunol.2021 Mar 15;352:577477. doi: 10.1016/j.jneuroim.2021.577477. Epub 2021 Jan 8. PMID: 33454553


• Takeda K, Okumura K. Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice. Biomed Res. 2021;42(5):173-179. doi: 10.2220/biomedres.42.173. PMID: 34544993


• Fujimoto K, Uchida K, Yin E, Zhu J, Kojima Y, Uchiyama M, Yamamoto Y, Bashuda H, Matsumoto R, Tokushige K, Harada M, Inomata T, Kitaura J, Murakami A, Okumura K, Takeda K. Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation. Transpl Immunol. 2021 Aug;67:101405. doi: 10.1016/j.trim.2021.101405. Epub 2021 May 8. PMID: 33975012


• Yin E, Fukuhara T, Takeda K, Kojima Y, Fukuhara K, Ikejima K, Bashuda H, Kitaura J, Yagita H, Okumura K, Uchida K. Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury. Sci Rep.2021 Mar 18;11(1):6312. doi: 10.1038/s41598-021-85001-2. PMID: 33737554

2020

• Ohno T, Nakamura T, Nakae S, Morita H, Matsumoto K, Saito H, Takeda K, Okumura K, Azuma T. TSLP is a negative regulator of RANKL-induced osteoclastogenesis. Biochem Biophys Res Commun. 2020 Sep 24;530(3):508-512. doi: 10.1016/j.bbrc.2020.05.055. Epub 2020 Jun 26. PMID: 32600615


• Kojima Y, Nishina T, Nakano H, Okumura K, Takeda K. Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TRAIL-resistant Tumor Cells. Mol Cancer Ther. 2020 May;19(5):1123-1133. doi: 10.1158/1535-7163.MCT-19-0597. Epub 2020 Mar 10. PMID: 32156787


• Eshima H, Tamura Y, Kakehi S, Kakigi R, Hashimoto R, Funai K, Kawamori R, Watada H. A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice. J Appl Physiol (1985).2020 May 1;128(5):1153-1162. doi: 10.1152/japplphysiol.00530.2019. Epub 2020 Mar 26. PMID: 32213111


• Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L773-L786. doi: 10.1152/ajplung.00001.2020. Epub 2020 Mar 11. PMID: 32159369


• Hashimoto R, Lanier GM, Dhagia V, Joshi SR, Jordan A, Waddell I, Tuder R, Stenmark KR, Wolin MS, McMurtry IF, Gupte SA. Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L386-L401. doi: 10.1152/ajplung.00327.2019. Epub 2020 Jan 8. PMID: 31913656


• Hashimoto R, Kakigi R, Miyamoto Y, Nakamura K, Itoh S, Daida H, Okada T, Katoh Y. JAK-STAT-dependent regulation of scavenger receptors in LPS-activated murine macrophages. Eur J Pharmacol. 2020 Mar 15;871:172940. doi: 10.1016/j.ejphar.2020.172940. Epub 2020 Jan 20. PMID: 31968212

2019

• Oh-Hora M, Lu X, Shiokawa M, Takayanagi H, Yamasaki S. Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders. J Immunol. 2019 May 1;202(9):2616-2627. doi: 10.4049/jimmunol.1700610. Epub 2019 Mar 25. PMID: 30910863


• Cossu D, Yokoyama K, Sakanishi T, Momotani E, Hattori N. Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis. J Neuroimmunol. 2019 May 15;330:174-177. doi: 10.1016/j.jneuroim.2019.01.013. Epub 2019 Jan 23. PMID: 30738572


• Matsumura Y, Ito Y, Mezawa Y, Sulidan K, Daigo Y, Hiraga T, Mogushi K, Wali N, Suzuki H, Itoh T, Miyagi Y, Yokose T, Shimizu S, Takano A, Terao Y, Saeki H, Ozawa M, Abe M, Takeda S, Okumura K, Habu S, Hino O, Takeda K, Hamada M, Orimo A. Stromal fibroblasts induce metastatic tumor cell clusters via epithelial-mesenchymal plasticity. Life Sci Alliance. 2019 Jul 22;2(4):e201900425. doi: 10.26508/lsa.201900425. Print 2019 Aug. PMID: 31331982


• Mittal D, Lepletier A, Madore J, Aguilera AR, Stannard K, Blake SJ, Whitehall VLJ, Liu C, Bettington ML, Takeda K, Long GV, Scolyer RA, Lan R, Siemers N, Korman A, Teng MWL, Johnston RJ, Dougall WC, Smyth MJ. CD96 Is an Immune Checkpoint That Regulates CD8(+) T-cell Antitumor Function. Cancer Immunol Res. 2019 Apr;7(4):559-571. doi: 10.1158/2326-6066.CIR-18-0637. Epub 2019 Mar 20. PMID: 30894377


• Hashimoto R, Miyamoto Y, Itoh S, Daida H, Okada T, Katoh Y. Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca2+-enhanced adipogenesis in bone marrow stromal cells. J Physiol Sci. 2019 Sep;69(5):741-748. doi: 10.1007/s12576-019-00690-9. Epub 2019 Jun 29. PMID: 31256364


• Yoshikawa S, Oh-Hora M, Hashimoto R, Nagao T, Peters L, Egawa M, Ohta T, Miyake K, Adachi T, Kawano Y, Yamanishi Y, Karasuyama H. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal. 2019 Apr 9;12(576):eaav2060. doi: 10.1126/scisignal.aav2060. PMID: 30967512