Juntendo University, Tokyo, established in 1838.

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Institute for Environmental and Gender-Specific Medicine

 Introduction
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Introduction

Director:
Kenji Takamori, M.D., Ph.D.
 (Trustee, Juntendo University)
 (Specially Appointed Professor, Department of Dermatology and Allergology)

Deputy Director
Yoshihiko Araki, M.D., D.Med.Sci.
 (Associate Professor (Principal), Institute for Environmental and Gender-Specific Medicine, Department of Obstetrics & Gynecology)
Nobuyuki Ebihara, M.D., Ph.D.
 (Professor, Institute for Environmental and Gender-Specific Medicine, Department of Ophthalmology)

Associate Professors
Mitsutoshi Tominaga, Ph.D.
Kazuhisa Iwabuchi, Ph.D.
 (Professor, Graduate School of Health Care and Nursing)
Mitsuaki Yanagida, Ph.D.

Assistant Professor
Hitoshi Nakayama, Ph.D.
 (Associate Professor, Faculty of Health Care and Nursing)
Yayoi Kamata, Ph.D.
Kunihiro Hayakawa, Ph.D.
Eriko Komiya-Suyama, Ph.D.
Kenji Yamatoya, Ph.D.
Noriko Yokoyama, Ph.D.

Adjunct Assistant Professor
Hiroshi Yoshitake, M.D., Ph.D.

Technical staff
Masaru Kurosawa, Ph.D.

Research fellow (Cooperative researcher)
Moniga Sagita Catharina, Ph.D. (JSPS Postdoctoral Fellowship for Research in Japan)
Xiaojia Li, Ph.D.(AMED-CREST Research Fellow)

Postdoctoral Fellows
Kotaro Honda, Ph.D.
Sumika Toyama, Ph.D.

Assistant Technical Staff
Maki Fujishiro, M.S.
Ryota Kosuge
Tomomi Hotta
Chihiro Kobayashi, M.S.
Keiko Fukuda

Visiting Professors
Yasuyuki Igarashi, Ph.D.
 (Emeritus Prof. Dept. of Biomembrane and Biofunctional Chemistry, Grad. Sch. of Pharmaceutical Sciences, Hokkaido University)
Kenji Izuhara, M.D., Ph.D.
 (Prof. Div. of Medical Biochemistry, Dept. of Biomolecular Sciences, Saga Medical School)
Ryusuke Kakigi, M.D., Ph.D.
 (Prof. Dept. of Sensory-Motor Integration, National Institute for Physiological Sciences)
Kunio Shiota, D.V.M., Ph.D.
 (Prof. Waseda Research Institute for Science and Engineering)
Makoto Tsuda, Ph.D.
(Prof. Dept. of Life Innovation, Grad. Sch. of Pharmaceutical Sciences, Kyushu University)
Makoto Tominaga, M.D., Ph.D
 (Prof. Div. of Cell Signaling, National Institute for Physiological Sciences)
Yoshio Hirabayashi, Ph.D.
 (Senior Team Leader. Lab. for Molecular Membrane Neuroscience, RIKEN Brain Science Institute)
Hiroshi Matsuda, D.V.M., Ph.D.
 (Prof. Div. of Animal Life Science, Inst. of Agriculture, Tokyo Univ. of Agriculture and Technology)
Ikuro Maruyama, M.D., Ph.D.
 (Project Prof. Dept. of System Biology in Thromboregulation, Kagoshima Univ. Grad. Sch. of Medical and Dental Sciences)

Management Committees
Takashi Sakurai, M.D., Ph.D.
 (Prof. Dept. of Cellular and Molecular Pharmacology)
Takao Urabe, M.D., Ph.D.
 (Prof. Dept. of Neurology)
Tsuneo Kitamura, M.D., Ph.D.
 (Assoc.Prof. Dept. of Gastroenterology)
Masato Koike, M.D., Ph.D.
 (Prof. Dept. of Cell Biology and Neuroscience)
Norio Komatsu, M.D., Ph.D.
 (Prof. Dept. of Department of Hematology)
Masaaki Komatsu, Ph.D.
 (Prof. Dept. of Physiology)
Yasushi Suga, M.D., Ph.D.
 (Prof. Dept. of Dermatology and Allergology)
Hiroshi Tanaka, M.D., Ph.D.
 (Prof. Dept. of Emergency and critical care medicine)
Sachiko Miyake, M.D., Ph.D.
 (Prof. Dept. of Immunology)
Chikao Morimoto, M.D.,
 (Visiting Prof. Dept. of Therapy Development and Innovation for Immune disorders and Cancers)
Takehiko Yokomizo, M.D., Ph.D.
 (Prof. Dept. of Molecular and Cellular Biochemistry)
Hidefumi Waki, Ph.D.
 (Prof. Grad. Sch. of Health and Sports Science)
Hirotaka Watada, M.D., Ph.D
 (Prof. Dept. of Medicine, Metabolism and Endocrinology)

Preface

   The Institute for Environmental and Gender-Specific Medicine (the first Director: Prof. Hideoki Ogawa) was established in 2002, supported in part by the “High-Tech Research Center” Project for Private Universities: matching fund subsidy from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT). Since that time, we have focused our research on the field of environmental/gender-specific medicine and related fields. In addition, a project concerning analysis of the fundamental mechanism of intractable itch to develop new therapies for severe symptoms has been funded in part by MEXT from 2013 to the present. At present, many inter/intra-institutional researchers have been pursuing several collaborative studies. The main research groups are as follows:
  1. Biological effects of environmental factors (environmental pollutants)
  2. The relationship between environmental factors and their effects on disease-related genes
  3. Gender specific medicine

     For graduate students, we have a course concerning “Environmental and Gender-Specific Medicine,” organized by faculty members. Here are the topics of our research including collaborators.
    ① Molecular mechanisms of epidermal innervation
    ② The effect of environmental factors on atopic dermatitis
    ③ Evaluation of the effect of exogenous endocrine disrupting chemicals on the innate immune system
    ④ Molecular dynamics of escape mechanisms of mycobacterium from neutrophil killing.
    ⑤ Study of structure and signal transduction mechanisms of glycosphingolipid-supramolecular
        domains involved in adhesion, migration and phagocytosis of leukocytes
    ⑥ Development and applications of immunoassay for the quantification of oxidative stress marker,
        6-nitrotryptophan.
    ⑦ Biological effects of metals during environmental changesn
    ⑧ Pathological effect of cigarette smoke chronic exposure on the progression of pulmonarys
        emphysema and regenerative effect of retinoid on the pulmonary alveolus.
    ⑨ Mechanisms of autoimmunity induced by drug administration
    ⑩ Development of new strategies for autoimmune disease therapy
    ⑪ Pathogenetical mechanisms of systemic lupus erythematodes (SLE)
    ⑫ Disorder of gene transcription and autoimmunity: epigenetic analysis
    ⑬ Effects of the sex hormones on DNA transcription
    ⑭ Proteomic analysis of the patients with rheumatoid arthritis and other autoimmune diseases
    ⑮ Pathogenesis of lymphangioleiomyomatosis
    ⑯ Biological significance of sexual dimorphism on the gametogenesis.
    ⑰ Biological function(s) of glycosylphosphatidylinositol-anchored proteins in mammals.otein in mammals.
 Introduction
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