Institute for Environmental and Gender-Specific Medicine
Kenji Takamori, M.D., Ph.D.
(Trustee, Juntendo University)
(Specially Appointed Professor, Department of Dermatology and Allergology)
Iwao Sekigawa, M.D., Ph.D.
(Professor, Department of Internal Medicine and Rheumatology)
Hitoshi Nakayama, Ph.D.
(Associate Professor, Faculty of Health Care and Nursing)
Yayoi Kamata, Ph.D.
Adjunct Assistant Professor：
Hiroshi Yoshitake, M.D., Ph.D.
Masaru Kurosawa, Ph.D.
Research fellow (Collaborative Researcher)：
Yuko Yoshida, Ph.D. (JSPS Research Fellow)
Yoshie Umehara, Ph.D.
Kunihiro Hayakawa, Ph.D.
Eriko Suyama, Ph.D.
Madoka Kage, Ph.D.
Kotaro Honda, Ph.D.
Sumika Toyama, Ph.D.
Xiaojia Li, Ph.D.
Assistant Technical Staff：
Maki Fujishiro, M.S.
Noriko Yokoyama, Ph.D.
Azumi Sakaguchi, M.S.
Chihiro Kobayashi, M.S.
Yasuyuki Igarashi, Ph.D.
(Emeritus Prof. Dept. of Biomembrane and Biofunctional Chemistry, Grad. Sch. of Pharmaceutical Sciences, Hokkaido University)
Kenji Izuhara, M.D., Ph.D.
(Prof. Div. of Medical Biochemistry, Dept. of Biomolecular Sciences, Saga Medical School)
Ryusuke Kakigi, M.D., Ph.D.
(Prof. Dept. of Sensory-Motor Integration, National Institute for Physiological Sciences)
Kunio Shiota, D.V.M., Ph.D.
(Prof. Waseda Research Institute for Science and Engineering)
Makoto Tsuda, Ph.D.
（Prof. Dept. of Life Innovation, Grad. Sch. of Pharmaceutical Sciences, Kyushu University）
Makoto Tominaga, M.D., Ph.D
(Prof. Div. of Cell Signaling, National Institute for Physiological Sciences)
Yoshio Hirabayashi, Ph.D.
(Senior Team Leader. Lab. for Molecular Membrane Neuroscience, RIKEN Brain Science Institute)
Hiroshi Matsuda, D.V.M., Ph.D.
(Prof. Div. of Animal Life Science, Inst. of Agriculture, Tokyo Univ. of Agriculture and Technology)
Ikuro Maruyama, M.D., Ph.D.
(Project Prof. Dept. of System Biology in Thromboregulation, Kagoshima Univ. Grad. Sch. of Medical and Dental Sciences)
Shigeki Yamaguchi, M.D., Ph.D.
(Prof. Dept. of Anesthesiology, Dokkyo Medical University)
Sakurai Takashi, M.D., Ph.D.
(Prof. Dept. of Cellular and Molecular Pharmacology)
Takao Urabe, M.D., Ph.D.
(Prof. Dept. of Neurology)
Tsuneo Kitamura, M.D., Ph.D.
(Assoc.Prof. Dept. of Gastroenterology)
Masato Koike, M.D., Ph.D.
(Prof. Dept. of Cell Biology and Neuroscience)
Yasushi Suga, M.D., Ph.D.
(Prof. Dept. of Dermatology and Allergology)
Kuniaki Seyama, M.D., Ph.D.
(Assoc.Prof. Dept. of Respiratory Medicine)
Hiroshi Tanaka, M.D., Ph.D.
(Prof. Dept. of Emergency and critical care medicine)
Sachiko Miyake, M.D., Ph.D.
(Prof. Dept. of Immunology)
Chikao Morimoto, M.D.,
(Visiting Prof. Dept. of Therapy Development and Innovation for Immune disorders and Cancers)
Fumiyuki Yamakura, Ph.D.
(Prof. Faculty of International Liberal Arts)
Takehiko Yokomizo, M.D., Ph.D.
(Prof. Dept. of Molecular and Cellular Biochemistry)
Hidefumi Waki, Ph.D.
(Prof. Grad. Sch. of Health and Sports Science)
Hirotaka Watada, M.D., Ph.D
(Prof. Dept. of Medicine, Metabolism and Endocrinology)
PrefaceThe Institute for Environmental and Gender-Specific Medicine (the first Director: Prof. Hideoki Ogawa) was established in 2002, supported in part by the “High-Tech Research Center” Project for Private Universities: matching fund subsidy from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT). Since that time, we have focused our research on the field of environmental/gender-specific medicine and related fields. In addition, a project concerning analysis of the fundamental mechanism of intractable itch to develop new therapies for severe symptoms has been funded in part by MEXT from 2013 to the present. At present, many inter/intra-institutional researchers have been pursuing several collaborative studies. The main research groups are as follows:
- Biological effects of environmental factors (environmental pollutants)
- The relationship between environmental factors and their effects on disease-related genes
- Gender specific medicine
For graduate students, we have a course concerning “Environmental and Gender-Specific Medicine,” organized by faculty members. Here are the topics of our research including collaborators.
① Molecular mechanisms of epidermal innervation
② The effect of environmental factors on atopic dermatitis
③ Evaluation of the effect of exogenous endocrine disrupting chemicals on the innate immune system
④ Molecular dynamics of escape mechanisms of mycobacterium from neutrophil killing.
⑤ Study of structure and signal transduction mechanisms of glycosphingolipid-supramolecular
domains involved in adhesion, migration and phagocytosis of leukocytes
⑥ Development and applications of immunoassay for the quantification of oxidative stress marker,
⑦ Biological effects of metals during environmental changesn
⑧ Pathological effect of cigarette smoke chronic exposure on the progression of pulmonarys
emphysema and regenerative effect of retinoid on the pulmonary alveolus.
⑨ Mechanisms of autoimmunity induced by drug administration
⑩ Development of new strategies for autoimmune disease therapy
⑪ Pathogenetical mechanisms of systemic lupus erythematodes (SLE)
⑫ Disorder of gene transcription and autoimmunity: epigenetic analysis
⑬ Effects of the sex hormones on DNA transcription
⑭ Proteomic analysis of the patients with rheumatoid arthritis and other autoimmune diseases
⑮ Pathogenesis of lymphangioleiomyomatosis
⑯ Biological significance of sexual dimorphism on the gametogenesis.
⑰ Biological function(s) of glycosylphosphatidylinositol-anchored proteins in mammals.otein in mammals.