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池田勝久（イケダカツヒサ）

研究テーマ	分子遺伝学による難聴研究
研究業績（論文）	Oshima T, Ueda N, Ikeda K, Abe K, Takasaka T. Hearing loss with a mitochondrial gene mutation is highly prevalent in Japan. Laryngoscope 109:334-338, 1999. Minowa O#, Ikeda K#, Sugitani Y, Oshima T, Nakai S, Katori Y, Suzuki M, Furukawa M, Kawase T, Zheng Y, Ogura M, Asada Y, Watanabe K, Yamanaka H, Gotoh S, Nishi-Takeshima M, Hamada H, Sugimoto T, Kikuchi T, Takasaka T, Noda T. Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science 285, 1408-1411, 1999 Oshima T, Ikeda K, Takasaka T. Sensorineural hearing loss associated with Byler disease. Tohoku J Exp Med 187:83-88, 1999. Kudo T, Ikeda K, Kure S, Matubara Y, Oshima T, Watanabe K, Kawase T, Narisawa K, Takasaka T. New common mutations in the connexin 26 gene (GJB2) in childhood deafness in the Japanese population. Am J Med Genet 90:141-145, 2000. 189, 2001. Kudo T, Ikeda K, Oshima T, Kure S, Tammasaeng M, Prasansuk S, Matsubara Y. 　GJB2 (connexin 26) mutations and children deafness in Thailand. Otol Neurol. 22:858-861, 2001. Oshima T, Kudo T, Ikeda K. Point mutation of the mitochondrial genome in Japanese deaf-mutism. ORL J Otol-Rhino-Laryngol 63:329-332, 2001. Kudo T, Kure S, Ikeda K, Xia A-P, Katori Y, Kobayashi T, Kojima K, Ichinohe A,, Suzuki Y, Aoki Y, Matsubara Y. Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness. Hum Mol Genet 12:995-1004, 2003. Ikeda K: Gene-based deafness research: Ion transport and hearing. Tohoku J Exp Med 1-11, 2004. Kudo T, Oshima T, Kure S, Matsubara Y, Ikeda K. Mutation detection of GJB2 using IsoCode and real-time quantitative polymerase chain reaction with SYBA green I dye for newborn hearing screening. Laryngoscope. 114:1299-1304, 2004. Nakada K, Sato A, Sone H, Kasahara A, Ikeda K, Kagawa Y, Yonekawa H, Hayashi J-I. Accumulation of pathogenic ΔmtDNA induced deafness but not diabetic phenotypes in mito-mice. Biochem Biophys Res Com 323:175-184, 2004. Kamada F, Kure S, Kudo T, Suzuki Y, Oshima T, Ichinobe A, Kojima K, Niihori T, Kanno J, Narumi Y, Narisawa A, Kato K, Aoki Y, Ikeda K, Kobayashi T, Matsubara Y. A novel KCNQ4 one-base deletion in a large pedigree with hearing loss: implication for the genotype-phenotype correlation. J Hum Genet 51:455-460, 2006. Inoshita A, Iizuka T, Okamura HO, Minekawa A, Kojima K, Furukawa M, Kusunoki T,Ikeda K:Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice. Neuroscience. 28;156(4):1039-47, 2008. Iizuka T, Kanzaki S, Mochizuki H, Inoshita A, Narui Y, Furukawa M, Kusunoki T, Saji M, Ogawa K, Ikeda K:Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea. 19(4):384-90, 2008. Narui Y, Minekawa A, Iizuka T, Furukawa M, Kusunoki T, Koike T, Ikeda K. Development of distortion product Otoacoustic emissions in C57BL/6J mice. Int J Audiol, 48:576-81, 2009. Minekawa A, Abe T, Inoshita A, Iizuka T, Kakehata S, Narui Y, Koike T, Kamiya K, okamura HO, Shinkawa H, Ikeda K. Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission. Neuroscience 164:1312-1319, 2009 Kumano S, Iida K, Murakoshi K, Tsumoto K, Ikeda K, Kumagai I, Kobayashi T, Wada H. Salicylate-induced translocation of prestin having mutation in the GTSRH sequence to the plasma membrane. FEBS Letters 584:2327-2332,2010. Kasai M, Hayashi C, Iizuka T, Inoshita A, Kamiya K, Okada H, Nakajima Y, Kaga K, Ikeda K. Vestibular function of patients with profound deafness related to GJB2 mutation. Acta Otolaryngol, 130:990-995, 2010. Ishihara K, Okuyama S, Kumano S, Iida K, Hamana H, Murakoshi M, Kobayashi T, Usami S, Ikeda K, Haga Y, Tsumoto K, Nakamura H, Hirasawa N, Wada H. Salicylate restores transport function and anion exchanger activity of missense pendrin mutations. Hear Res. 2010 Dec 1;270(1-2):110-8. Yoshikawa S, Kawano A, Hayashi C, Nishiyama N, Kawaguchi S, Furuse H, Ikeda K, Suzuki M, Nakagawa M. The clinical features of patients with the homozygous 235delC and the compound-heterozygous Y136X/G45E of the GJB2 mutations (Connexin 26) in cochlear implant recipients. A uris N asus Larynx. 2011 Aug;38(4):444-9. Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K. Bacteriology of recurrent exacerbation of postoperative course in chronic hinosinusitis in relation to asthma. A uris N asus Larynx. 2011 Aug;38(4):469-73. Hayashi C, Funayama M, Li Y, Kamiya K, Kawano A, Suzuki M, Hattori N, Ikeda K. Prevalence of GJB2 causing recessive profound non-syndromic deafness in Japanese children.Int J Pediatr Otorhinolaryngol. 2011 Feb;75(2):211-4. Okada H, Iizuka T, Mochizuki H, Nihira T, Kamiya K, Inoshita A, Kasagi H, Kasai M, Ikeda K, Gene transfer targeting mouse vestibule using adenovirus and adeno-associated virus vectors, Otology&Neurotology. 2012 Jun;33(4):655-9. Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sakaki S, Uchida S. Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice. Biochem Biophys Res Commun. 2013 Nov 22;441(3):544-9. Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K. Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest. 2014 Mar 3. pii:67621. Inoshita A, Karasawa K, Funakubo M, Miwa A, Ikeda K, Kamiya K. Dominant negative connexin26 mutation R75W causing severe hearing loss influences normal programmed cell death in postnatal organ of Corti. BMC Genet. 2014 Jan 3;15:1

研究テーマ

分子遺伝学による難聴研究

研究業績（論文）

Oshima T*, Ueda N, Ikeda K, Abe K, Takasaka T. Hearing loss with a mitochondrial gene mutation is highly prevalent in Japan. Laryngoscope 109:334-338, 1999.

Minowa O#, Ikeda K#, Sugitani Y, Oshima T, Nakai S, Katori Y, Suzuki M, Furukawa M, Kawase T, Zheng Y, Ogura M, Asada Y, Watanabe K, Yamanaka H, Gotoh S, Nishi-Takeshima M, Hamada H, Sugimoto T, Kikuchi T, Takasaka T, Noda T*. Altered cochlear fibrocytes in a mouse model of DFN3 nonsyndromic deafness. Science 285, 1408-1411, 1999

Oshima T*, Ikeda K, Takasaka T. Sensorineural hearing loss associated with Byler disease. Tohoku J Exp Med 187:83-88, 1999.

Kudo T*, Ikeda K, Kure S, Matubara Y, Oshima T, Watanabe K, Kawase T, Narisawa K, Takasaka T. New common mutations in the connexin 26 gene (GJB2) in childhood deafness in the Japanese population. Am J Med Genet 90:141-145, 2000.
189, 2001.

Kudo T*, Ikeda K, Oshima T, Kure S, Tammasaeng M, Prasansuk S, Matsubara Y. 　GJB2 (connexin 26) mutations and children deafness in Thailand. Otol Neurol. 22:858-861, 2001.

Oshima T*, Kudo T, Ikeda K. Point mutation of the mitochondrial genome in Japanese deaf-mutism. ORL J Otol-Rhino-Laryngol 63:329-332, 2001.

Kudo T, Kure S*, Ikeda K, Xia A-P, Katori Y, Kobayashi T, Kojima K, Ichinohe A,, Suzuki Y, Aoki Y, Matsubara Y. Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness. Hum Mol Genet 12:995-1004, 2003.

Ikeda K: Gene-based deafness research: Ion transport and hearing. Tohoku J Exp Med 1-11, 2004.

Kudo T, Oshima T, Kure S, Matsubara Y, Ikeda K. Mutation detection of GJB2 using IsoCode and real-time quantitative polymerase chain reaction with SYBA green I dye for newborn hearing screening. Laryngoscope. 114:1299-1304, 2004.

Nakada K, Sato A, Sone H, Kasahara A, Ikeda K, Kagawa Y, Yonekawa H, Hayashi J-I. Accumulation of pathogenic ΔmtDNA induced deafness but not diabetic phenotypes in mito-mice. Biochem Biophys Res Com 323:175-184, 2004.

Kamada F, Kure S*, Kudo T, Suzuki Y, Oshima T, Ichinobe A, Kojima K, Niihori T, Kanno J, Narumi Y, Narisawa A, Kato K, Aoki Y, Ikeda K, Kobayashi T, Matsubara Y. A novel KCNQ4 one-base deletion in a large pedigree with hearing loss: implication for the genotype-phenotype correlation. J Hum Genet 51:455-460, 2006.

Inoshita A, Iizuka T, Okamura HO, Minekawa A, Kojima K, Furukawa M, Kusunoki T,Ikeda K:Postnatal development of the organ of Corti in dominant-negative Gjb2 transgenic mice. Neuroscience. 28;156(4):1039-47, 2008.

Iizuka T, Kanzaki S, Mochizuki H, Inoshita A, Narui Y, Furukawa M, Kusunoki T, Saji M, Ogawa K, Ikeda K:Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea. 19(4):384-90, 2008.

Narui Y, Minekawa A, Iizuka T, Furukawa M, Kusunoki T, Koike T, Ikeda K. Development of distortion product Otoacoustic emissions in C57BL/6J mice. Int J Audiol, 48:576-81, 2009.

Minekawa A, Abe T, Inoshita A, Iizuka T, Kakehata S, Narui Y, Koike T, Kamiya K, okamura HO, Shinkawa H, Ikeda K. Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission. Neuroscience 164:1312-1319, 2009

Kumano S, Iida K, Murakoshi K, Tsumoto K, Ikeda K, Kumagai I, Kobayashi T, Wada H. Salicylate-induced translocation of prestin having mutation in the GTSRH sequence to the plasma membrane. FEBS Letters 584:2327-2332,2010.

Kasai M, Hayashi C, Iizuka T, Inoshita A, Kamiya K, Okada H, Nakajima Y, Kaga K, Ikeda K. Vestibular function of patients with profound deafness related to GJB2 mutation. Acta Otolaryngol, 130:990-995, 2010.

Ishihara K, Okuyama S, Kumano S, Iida K, Hamana H, Murakoshi M, Kobayashi T, Usami S, Ikeda K, Haga Y, Tsumoto K, Nakamura H, Hirasawa N, Wada H. Salicylate restores transport function and anion exchanger activity of missense pendrin mutations. Hear Res. 2010 Dec 1;270(1-2):110-8.

Yoshikawa S, Kawano A, Hayashi C, Nishiyama N, Kawaguchi S, Furuse H, Ikeda K, Suzuki M, Nakagawa M. The clinical features of patients with the homozygous 235delC and the compound-heterozygous Y136X/G45E of the GJB2 mutations (Connexin 26) in cochlear implant recipients. A uris N asus Larynx. 2011 Aug;38(4):444-9.

Ikeda K, Yokoi H, Kusunoki T, Saitoh T, Yao T, Kase K, Minekawa A, Inoshita A, Kawano K. Bacteriology of recurrent exacerbation of postoperative course in chronic hinosinusitis in relation to asthma. A uris N asus Larynx. 2011 Aug;38(4):469-73.

Hayashi C, Funayama M, Li Y, Kamiya K, Kawano A, Suzuki M, Hattori N, Ikeda K. Prevalence of GJB2 causing recessive profound non-syndromic deafness in Japanese children.Int J Pediatr Otorhinolaryngol. 2011 Feb;75(2):211-4.

Okada H, Iizuka T, Mochizuki H, Nihira T, Kamiya K, Inoshita A, Kasagi H, Kasai M, Ikeda K, Gene transfer targeting mouse vestibule using adenovirus and adeno-associated virus vectors, Otology&Neurotology. 2012 Jun;33(4):655-9.

Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sakaki S, Uchida S. Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice. Biochem Biophys Res Commun. 2013 Nov 22;441(3):544-9.

Kamiya K, Yum SW, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, Miwa A, Guo X, Gotoh S, Sugitani Y, Yamanaka H, Ito-Kawashima S, Iizuka T, Sakurai T, Noda T, Minowa O, Ikeda K. Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest. 2014 Mar 3. pii:67621.

Inoshita A, Karasawa K, Funakubo M, Miwa A, Ikeda K, Kamiya K. Dominant negative connexin26 mutation R75W causing severe hearing loss influences normal programmed cell death in postnatal organ of Corti. BMC Genet. 2014 Jan 3;15:1

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研究業績詳細

池田 勝久（イケダ カツヒサ）

池田勝久（イケダカツヒサ）