学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

齋藤剛（サイトウツヨシ）

研究テーマ	悪性腫瘍における臨床病理学的・分子病理学的解析
研究業績（論文）	1) Oda Y, Sakamoto A, Saito T, Kinukawa N, Iwamoto Y, Tsuneyoshi M. Expression of hepatocyte growth factor (HGF)/scatter factor and its receptor c-MET correlates with poor prognosis in synovial sarcoma. Hum Pathol. 2000, 31:185-92. 2) Kawauchi S, Fukuda T, Oda Y, Saito T, Oga A, Takeshita M, Yokoyama K, Chuman H, Iwamoto Y, Sasaki K, Tsuneyoshi M. Prognostic significance of apoptosis in synovial sarcoma: correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins. Mod Pathol. 2000, 13:755-765, 2000 3) Oda Y, Sakamoto A, Saito T, Kawauchi S, Iwamoto Y, Tsuneyoshi M. Molecular abnormalities of p53, MDM2, and H-ras in synovial sarcoma. Mod Pathol. 13:994-1004, 2000. 4) Saito T, Oda Y, Sakamoto A, Tamiya S, Kinukawa N, Hayashi K, Iwamoto Y, Tsuneyoshi M. Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of -catenin mutation in synovial sarcoma. J Pathol. 2000, 192:342-350. 5) Shiratsuchi H, Oshiro Y, Saito T, Itakura E, Kinoshita Y, Tamiya S, Oda Y, Komiyama S, Tsuneyoshi M. Cytokeratin subunits of inclusion bodies in rhabdoid cells: Immunohistochemical and clinicopathological study of malignant rhabdoid tumor and epithelioid sarcoma. Int J Surg Pathol. 2001, 9:37-48. 6) Adachi T, Oda Y, Sakamoto A, Saito T, Tamiya S, Masuda K, Tsuneyoshi M. Immunoreactivity of p53, mdm2, and p21WAF1 in dedifferentiated liposarcoma: special emphasis on distinct immunophenotype in well-differentiated component. Int J Surg Pathol. 2001, 9:99-109. 7) Oda Y, Sakamoto A, Saito T, Matsuda S, Tanaka K, Iwamoto Y, Tsuneyoshi M. Secondary malignant giant-cell tumor of bone: Molecular abnormalities of p53 and H-ras gene correlated with malignant transformation. Histopathology 2001, 39:629-637. 8) Saito T, Oda Y, Itakura E, Shiratuchi H, Kinoshita Y, Oshiro Y, Tamiya S, Hachitanda Y, Iwamoto Y, Tsuneyoshi M. Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor. Pathol Int. 2001, 51:532-42. 9) Saito T, Oda Y, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M. -catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumors. J Pathol. 2001, 195:222-228. 10) Saito T, Oda Y, Sugimachi K, Kawaguchi K, Tamiya S, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y, Tsuneyoshi M. E-cadherin gene mutations frequently occur in synovial sarcoma as a determinant of histological features. Am J Pathol. 2001, 159:2117-2124. 11) Saito T, Oda Y, Kawaguchi K, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M. Possible Association between Higher -catenin mRNA Expression and Mutated -catenin in Sporadic Desmoid Tumors: Real-Time Semiquantitative Assay by TaqMan Polymerase Chain Reaction. Lab Invest. 2002, 82:97-103. 12) Shiratsuchi H, Saito T, Sakamoto A, Itakura E, Tamiya S, Oshiro Y, Oda Y, Toh S, Komiyama S, Tsuneyoshi M.　Mutation analysis of human cytokeratin 8 (KRT 8) gene in malignant rhabdoid tumor: A possible contribution to intracytoplasmic inclusion body formation. Mod Pathol. 2002, 15:146-153. 13) Saito T, Oda Y, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characteristics in synovial sarcoma. Histopathology. 2002, 40:279-285. 14) Saito T, Oda Y, Sakamoto A, Kawaguchi K, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M. APC mutations in synovial sarcoma. J Pathol. 2002, 196:445-449. 15) Kawaguchi K, Oda Y, Nakanishi K, Saito T, Tamiya S, Nakahara K, Matsuoka H, Tsuneyoshi M. Malignant Transformation of Renal Angiomyolipoma: A Case Report. Am J Surg Pathol. 2002, 26:523-529. 16) Kawaguchi K, Oda Y, Sakamoto A, Saito T, Tamiya S, Iwamoto Y, Tsuneyoshi M. Molecular analysis of p53, MDM2 and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. Mod Pathol. 2002, 15:878-888. 17) Sakamoto A, Oda Y, Adachi T, Saito T, Matsuda S, Tanaka K, Oshiro Y, Tamiya S, Iwamoto Y, Tsuneyoshi M. -catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma. Arch Pathol Lab Med. 2002, 126:1071-1078. 18) Oda Y, Ohishi Y, Saito T, Hinoshita E, Uchiumi T, Kinukawa N, Iwamoto Y, Kohno K, Kuwano M, Tsuneyoshi M. Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma. J Pathol. 2003, 199:251-258. 19) Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Tanaka K, Matsuda S, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcoma without specific balanced translocations. Int J Cancer. 2003, 104:175-178. 20) Yamamoto H, Oda Y, Saito T, Sakamoto A, Miyajima K, Tamiya S, Nakamori M, Tsuneyoshi M. p53 mutation and MDM2 amplification in inflammatory myofibroblastic tumours. Histopathology. 2003, 42:431-439. 21) Saito T, Oda Y, Kawaguchi K, Takahira T, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. Possible asociation between tumor suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma. Hum Pathol. 2003, 34:841-849. 22) Adachi T, Oda Y, Sakamoto A, Saito T, Tamiya S, Hachitanda Y, Masuda S, Tsuneyoshi M. Mixed tumor of deep soft tissue. Pathol Int. 2003, 53:35-39. 23) Saito T, Oda Y, Tanaka K, Matsuda S, Sakamoto A, Yamamoto H, Iwamoto Y, Tsuneyoshi M. Low-grade fibrosarcoma of the proximal humerus. Pathol Int. 2003, 53:115-120. 24) Kawaguchi K, Oda Y, Saito T, Yamamoto H, Tamiya S, Takahira T, Miyajima K, Iwamoto Y, Tsuneyoshi M. Mechanism of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor prognosis. J Pathol. 2003, 201:487-495. 25) Kawaguchi K, Oda Y, Saito T, Tamiya S, Yamamoto H, Tanaka K, Matsuda S, Iwamoto Y, Tsuneyoshi M. Decreased Expression of TGF- II Receptor Associates with that of p27KIP1 in Giant Cell Tumor of Bone: The Correlation Between TGF- Receptors and Cell Cycle-related Proteins. Hum Pathol. 2004, 35:61-68. 26) Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Tamiya S, Iwamoto Y, Tsuneyoshi M. Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression. Hum Pathol. 2004, 35:1266-1271. 27) Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, Saito T, Oshiro Y, Ohta M, Yao T, Tsuneyoshi M. c-kit and PDGFRA Mutations in Extragastrointestinal Stromal Tumor (Gastrointestinal stromal tumor of the soft part). Am J Surg Pathol. 2004, 28:479-488. 28) Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Tanaka K, Matsuda S, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcoma. Oncol Rep.2004, 11:1011-1015. 29) Saito T, Oda Y, Kawaguchi K, Yamamoto H, Sugimachi K, Tateishi N, Tanaka K, Matsuda S, Iwamoto Y, Ladanyi M, Tsuneyoshi M. E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma. Oncogene. 2004, 23:8629-8638. 30) Oda Y, Saito T, Tateishi N, Ohishi Y, Tamiya S, Yamamoto H, Yokoyama R, Uchiumi T, Iwamoto Y, Kuwano M, tsuneyoshi M. ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcomas. Int J Cancer. 2005, 114:854-862. 31) Saito T, Oda Y, Kawaguchi K, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y, Tsuneyoshi M. Five-year evolution of a telangiectatic osteosarcoma initially managed as an aneurismal bone cyst. Skeletal Radiol 2005, 34:290-294. 32) Kawaguchi K, Oda Y, Takahira T, Saito T, Yamamoto H, Kobayashi C, Tamiya S, Oda S, Iwamoto Y, Tsuneyoshi M. Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomas. Oncol Rep 2005, 13:241-246. 33) Kawaguchi K, Oda Y, Saito T, Takahira T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M. Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas. Hum Pathol. 2005, 36:357-63. 34) Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Kobayashi C, Tamiya S, Tateishi N, Iwamoto Y, Tsuneyoshi M. DNA hypermethylation status of multiple genes in soft tissue sarcomas. Mod Pathol. 2006, 19:106-114. 35) Saito T, Oda Y, Yamamoto H, Kawaguchi K, Tanaka K, Matsuda S, Iwamoto Y, Tsuneyoshi M. Nuclear -catenin correlates with cyclin D1 expression in spindle and pleomorphic sarcomas but not in synovial sarcoma. Hum Pathol. 2006, 37:689-697. 36) Izumi T, Hasegawa T, Nakanishi Y, Iwasaki H, Sonobe H, Goto H, Kusakabe H, Takahira T, Kobayashi T, Kawaguchi K, Saito T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M. Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. Mod Pathol. 2006, 19:820-831. 37) Saito T, Nagai M, Ladanyi M. SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by Snail and Slug. A potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma. Cancer Res. 2006, 68:6919-6927. 38) Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR, Downs-Kelly E, Corless CL, Rubin BP, van de Rijn M, Ladanyi M, Nielsen TO. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol. 2007, 31:240-246. 39) Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Lae M, Fisher DE, Ladanyi M. TFE3 fusions activates MET signaling by the transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res. 2007, 67:919-929. 40) Shiratsuchi H, Nakashima T, Hirakawa N, Toh S, Nakagawa T, Saito T, Tsuneyoshi M, Komune S. beta-catenin nuclear accumulation in head and neck mucoepidermoid carcinoma: its role in cyclin D1 expression and tumor progression. Head Neck. 2007, 29:577-584. 41) Matono H, Oda Y, Nakamori M, Tamiya S, Yamamoto H, Yokoyama R, Saito T, Iwamoto Y, Tsuneyoshi M. Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoids tumors. Hum Pathol. 2008, 39:1802-1808. 42) Mitomi H, Fukui N, Tanaka N, Kanazawa H, Saito T, Matsuoka T, Yao T. Aberrant p16(INK4a) methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity. J Cancer Res Clin Oncol. 2010, 136:323-331. 43) Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 2010, 42:715-721. 44) Yokotsuka M, Iwaya K, Saito T, Pandiella A, Tsuboi R, Kohno N, Matsubara O, Mukai K. Overexpression of HER2 signaling to WAVE2–Arp2/3 complex activates MMP-independent migration in breast cancer. Breast Cancer Res Treat 2011, 126:311-318. 45) Saito T, Mitomi H, Izumi H, Suehara Y, Torigoe T, Takagi T, Kaneko K, Sato K, Matsumoto T, Yao T. A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-time follow-up. Human Pathol, 2011, 42:727-733. 46) Matono H, Tamiya S, Yokoyama R, Saito T, Iwamoto Y, Tsuneyoshi M, Oda Y. Abnormalities of Wnt/-catenin signaling pathway induce tumor progression in sporadic desmoids tumors: correlation between -catenin widespread nuclear expression and VEGF overexpression. Histopathology. 2011, 59:368-375. 47) Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T, Yao T. Cluster analysis of claudin-1 and -4, E-cadherin and -catenin expression in colorectal cancers. J Surg Oncol. 2011, 103:674-686. 48) Mitomi H, Fukui N, Kishimoto I, Tanabe S, Kikuchi S, Saito T, Hayashi T, Yao T. Role for p16(INK4a) in progression of gastrointestinal stromal tumors of the stomach: alteration of p16(INK4a) network members. Human Pathol. 2011, 42:1505-1513. 49) Fujimaki M, Fukumura Y, Saito T, Mitani K, Uchida S, Yokoyama J, Yao T, Ikeda K. Oncocytic mucoepidermoid carcinoma of the parotid gland with CRTC1-MAML2 fusion transcript: report of a case with review of literature. Human Pathol. 2011, 42:2052-2055. 50) Saito T, Mitomi H, Suehara Y, Okubo T, Torigoe T, Takagi T, Kaneko K, Yao T. A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. Pathol Res Pract, 2011, 207:664-669. 51) Torigoe T, Tomita Y, Iwase Y, Aritomi K, Suehara Y, Oukubo T, Sakurai A, Terakado A, Takagi T, Kaneko K, Saito T, Yazawa Y. Reconstruction using frozen autograft bone treated by liquid nitrogen for malignant bone tumor in the forearm: A new technique of pedicle freezing. J Ortho Surg. 2012, 20:98-102. 52) Yonezawa I, Saito T, Nakahara D, Won J, Wada T, Kaneko K. Synovial sarcoma of the cauda equina. J Neurosurg Spine. 2012, 16:187-190. 53) Imamhasan A, Mitomi H, Saito T, Arakawa A, Yao T. Clear cell variant of squamous cell carcinoma originating in the esophagus: Report of a case with immunohistochemical and oncogenetic analyses. Pathol Int. 2012, 62:137-143. 54) Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Yao T, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T. Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor. J Proteomics. 2012, 75:1089-1098. 55) Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Katagiri H, Murata H, Takahashi M, Ito I, Yao T, Kaneko K. Intraneural lipomatous tumor of median nerve: Report of 3 cases with literature review. Int J Surg Case Rep. 2012, 3:407-411. 56) Imamhasan A, Mitomi H, Saito T, Hayashi T, Takahashi M, Kajiyama Y, Yao T. Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. Human Pathol. 2012, 43:2012-2023. 57) Nakae K, Mitomi H, Saito T, Takahashi M, Morimoto T, Hidaka Y, Sakamoto N, Yao T, Watanabe S. MUC5AC/β-catenin expression and K-ras gene altered in laterally spreading colorectal tumors. World J Gastroenterol. 2012, 18:5551-5559. 58) Hayashi T, Koike K, Kumasaka T, Saito T, Mitani K, Terao Y, Ogishima D, Yao T, Takeda S, Takahashi K, Seyama K. Uterine angiosarcoma associated with lymphangioleiomyomatosis in a patient with tuberous sclerosis complex：An autopsy case report with immunohistochemical and genetic analysis. Human Pathol. 2012, 43:1777-1784. 59) Kubota D, Okubo T, Saito T, Suehara Y, Yoshida A, Kikuta K, Tsuda H, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T. Validation Study on Pfetin and ATP-dependent RNA helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumor. Jpn J Clin Oncol 2012, 42:730-741. 60) Saito T, Mitomi H, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Malignant granular cell tumor with unusual long clinical course. An autopsy case with review of literatures. J Cancer Sci Ther. 2012, 4:260-263. 61) Saito T, Yokotsuka M, Motoi T, Iwasaki H, Nagao T, Ladanyi M, Yao T. EWS-WT1 chimeric protein in desmoplastic small round cell tumor is a potent transactivator of FGFR4. J Cancer Sci Ther. 2012, 4:335-340. 62) Ho AL, Vasudeva SD, Barbashina V, Laé M, Saito T, Antonescu C, Ladanyi M, Schwartz GK. PDGFRA is an alternative mediator of Rapamycin-Induced Akt Activation in Synovial Sarcoma: implications for combination targeted therapy. Cancer Res 2012, 72:4515-4525. 63) Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Yao T, Kaneko K. Possible involvement of p53 genetic alteration associated with protein overexpression in malignant transformation of giant-cell tumor of bone. Virchows Archiv 2013, 63:67-77. 64) Suehara Y, Kubota D, Saito T. Tissue Sample Preparation for Biomarker Discovery. Methods Mol Biol. 2013, 1002:13-23. 65) Alkam Y, Mitomi H, Nakai K, Himuro T, Saito T, Takahashi M, Arakawa A, Yao T, Saito M. Protein expression and methylation of DNA repair genes hMLH1, hMSH2, MGMT and BRCA1 and their correlation with clinicopathological parameters and prognosis in basal-like breast cancer. Histopathology. 2013, 63:713-725. 66) Hidaka Y, Mitomi H, Saito T, Takahashi M, Lee SY, Matsumoto K, Yao T, Watanabe S. Alteration in the Wnt/β-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) type. Human Pathol. 2013, 44:2438-2448. 67) Hayashi T, Saito T, Fujimura T, Hara K, Takamochi K, Mitani K, Mineki R, Kazuno S, Oh S, Suzuki K, Ueno T, Suzuki K, Yao T. Galectin-4, a novel predictor for lymph node metastasis in lung adenocarcinoma: A proteomic study. PLoS One. 2013, 8:e81883. 68) Hamano A, Suzuki T, Saito T, Kuwatsuru R, Oh S, Suzuki K. Infiltrative angiolipoma of the thoracic wall: A case report. Open J Clin Diag. 2013, 3:19-22. 69) Saito T, Mitomi H, Kurisaki A, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Low-grade myofibroblastic sarcoma of the distal femur. Int J Surg Case Rep. 2013, 4:195-199. 70) Kobos R, Nagai M, Tsuda M, Lui MY, Saito T, Laé M, Mo Q, Olshen A, Lianoglou S, Leslie C, Shao Y, Antczak C, Djaballah H, Ladanyi M. A combined integrated genomics / functional genomics strategy to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein. J Pathol. 2013, 229:743-754. 71) Kubota D, Yoshida A, Tsuda H, Suehara Y, Okubo T, Saito T, Orita H, Sato K, Taguchi T, Yao T, Kaneko K, Katai H, Kawai A, Kondo T. Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor. PLoS One. 2013, 8:e73896. 72) Kubota D, Mukaihara K, Yoshida A, Suehara Y, Saito T, Okubo T, Gotoh M, Orita H, Tsuda H, Kaneko K, Kawai A, Kondo T, Sato K, Yao T. The prognostic value of pfetin: a validation study in gastrointestinal stromal tumors using a commercially available antibody. Jpn J Clin Oncol. 2013, 43:669-675. 73) Saito T, Ryu M, Fukumura Y, Asahina M, Arakawa A, Nakai K, Miura H, Saito M, Yao T. A case of myxoid liposarcoma of the breast. Int J Clin Exp Pathol. 2013, 6:1432-1436. 74) Okubo T, Saito T, Takagi T, Torigoe T, Suehara Y, Akaike K, Yao T, Kaneko K. Desmoplastic fibroma of the scapula with uptake of FDG-PET: A case report with review of literature. Int J Clin Exp Pathol. 2013, 6:2230-2236. 75) Kurisaki-Arakawa A, Saito T, Takahashi M, Mitani K, Fukumura Y, Nagashima Y, Argani P, Yao T. A case of bilateral renal cell carcinoma associated with long-term dialysis showing false-positive immunoreactivity for TFE3. Int J Clin Exp Pathol, 2013, 6:2585-2590. 76) Saito T. Review: SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling. Int J Clin Exp Pathol, 2013, 6:2272-2279. 77) Suehara Y, Kohsaka S, Kubota D, Mukaihara K, Akaike K, Mineki R, Fujimura T, Ladanyi M, Saito T, Kondo T. Review: Proteomic technologies to develop biomarkers and functional analyses in the bone and soft tissue tumors. J Proteo Bioinf, 2013 S3: 1-13. 78) Saito T, Mitomi H, Imamhasan A, Hayashi T, Mitani K, Takahashi M, Kajiyama Y, Yao T. Downregulation of sFRP-2 by epigenetic silencing activates the -catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. Virchows Arch 2014, 464:135-143. 79) Morimoto T, Mitomi H, Saito T, Takahashi M, Murakami T, Sakamoto N, Yao T, Watanabe S. Distinct profile of HIF1α, PTCH, EphB2 or DNA repair protein expression and BRAF mutation in colorectal serrated adenomas. J Gastroenterology and Hepatology. 2014, 29:1192-1199. 80) Toda M, Suehara Y, Akaike K, Okubo T, Kubota D, Mukaihara K, Kaneko K, Yao T, Takagi T, Saito T. Giant-cell tumor of bone arising in the anterior chest wall with positive expressions of GPX-1: a case report with review of literature. Int Canc Conf J. 2014, 3:178-182. 81) Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K. Desmoplastic fibroma of the rib with cystic change : a case report and literature review. Skeletal Radiol 2014, 43:703-708. 82) Okubo T, Suehara Y, Kawasaki T, Akaike K, Toda M, Okubo N, Kubota D, Mukaihara K, Kim Y, Kaketa T, Homma Y, Shimanouchi N, Saito T, Takagi T, Kaneko K. An outpatient-based survey about the recognition of locomotive syndrome and the results of the loco-check at a university hospital in Tokyo. Brit J Med Med Res, 2014, 4:3255-3268. 83) Masuda Y, Kurisaki-Arakawa A, Hara K, Arakawa A, Oh S, Suzuki K, Yao T, Saito T. A case of dedifferentiated solitary fibrous tumor of thoracic cavity. Int J Clin Exp Pathol, 2014, 7:386-393. 84) Shiono S, Saito T, Fujii H, Arakawa A, Nakamura T, Yao T. A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary. Int J Clin Exp Pathol, 2014, 7:394-401. 85) Akaike K, Suehara Y, Takagi T, Kaneko K, Saito T. Eggshell-like mineralized recurrent lesion in the popliteal region after treatment of giant cell tumor of bone with denosumab. Skeletal Radiol 2014, 43:1767-1772. 86) Kurisaki-Arakawa A, Saito T, Takahashi M, Mitani K, Yao T. A case of 123I-MIBG scintigram-negative functioning pheochromocytoma: Immunohistochemical and molecular analysis with review of literature. Int J Clin Exp Pathol. 2014, 7:4438-4447. 87) Kurisaki-Arakawa A, Akaike K, Hara K, Arakawa A, Takahashi M, Mitani K, Yao T, Saito T. A case of dedifferentiated solitary fibrous tumor in the pelvis with TP53 mutation. Virchows Arch 2014, 465:615-621. 88) Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T. Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy. Diagn Pathol. 2014, 9:163. 89) Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S Kaneko K, Horie S, Yao T. A case of primary spindle cell variant of rhabdomyosarcoma of the prostate in Young Adult. Int J Clin Exp Pathol, 2014, 7:5181-5185.. 90) Nomura R, Saito T, Mitomi H, Hidaka Y, Lee SY, Watanabe S, Yao T. GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. Human Pathol. 2014, 45:2488-2496. 91) Kurisaki-Arakawa A, Akaike K, Tomomasa R, Arakawa A, Suehara Y, Takagi T, Kaneko K, yao T, Saito T. A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion. Int J Surg Case Rep. 2014, 5:1123-1127. 92) Murakami T, Mitomi H, Saito T, Takahashi M, Sakamoto N, Fukui N, Yao T, Watanabe S. Distinct Wnt/-catenin signaling activation in the serrated neoplasia pathway and the adenoma-carcinoma sequence of the colorectum. Mod Pathol. 2015, 28:146-158. 93) Saito T, Mitomi H, Imamhasan A, Hayashi T, Kurisaki-Arakawa A, Mitani K, Takahashi M, Kajiyama Y, Yao T. PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma. Mutagenesis. 2015, 30:297-301. 94) Inaba T, Fukumura Y, Saito T, Yokoyama J, Ohba S, Yao T. Cytological features of mammary analogue secretary carcinoma of the parotid gland: A case report and review of the literature. Case Rep Pathol. 2015;2015:656107. 95) Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T. Distinct clinicopathologic features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. Human Pathol. 2015, 46:347-356. 96) Lee SY, Saito T, Mitomi H, Hidaka Y, Murakami T, Nomura R, Watanabe S, Yao T. Mutation spectrum of Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps. Virchows Arch. 2015, 467:27-38 97) Saito T, Mitomi H, Yao T. Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. Int J Clin Exp Pathol. 2015, 8:2267-2273. 98) Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur. In J Clin Exp Pathol. 2015, 8:3270-3278. 99) Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T. Spindle cell lipoma of the wrist, occurring in a distinctly rare location: A case report with review of literature. Int J Clin Exp Pathol. 2015, 8:3299-3303. 100) Hara K, Saito T, Hayashi T, Yimit A, Takahashi M, Mitani K, Takahashi M, Yao T. A mutation spectrum that includes GNAS, KRAS, and TP53 may be shared by mucinous neoplasms of the appendix. Pathol Res Pract. 2015, 21:657-664. 101) Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K , Saito T. Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases. PLoS One. 2015, 10:e0129428. 102) Hara K, Fukumura Y, Saito T, Arakawa A, Okabe H, Takeda S, Yao T. A giant cord hemangioma with extramedullary hematopoiesis and elevated maternal serum human chorionic gonadotropin: A case report and review of the literature. Diagn Pathol. 2015, 10:154. 103) Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T. TERT promoter mutations are a rare event in gastrointestinal stromal tumors. SpringerPlus. 2015, 4:836. 104) Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K. The Recognition of Locomotive Syndrome in 2014: A Cross-Sectional Study in the Orthopeadic Outpatients in Tokyo. Brit J Med Med Res 2015. 14207. 105) Murakami T, Yao T, Mitomi H, Morimoto T, Ueyama H, Matsumoto K, Saito T, Osada T, Nagahara A, Watanabe S. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric Cancer.　2016, 19:498-507. 106) Saito T, Akaike K, Kurisaki-Arakawa A, Toda-Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T. TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients. Mol Clin Oncol. 2016, 4:61-64. 107) Mukaihara K, Suehara Y, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi M, Kaneko K, Saito T. Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma. BMC Cancer. 2016, 16:206. 108) Imanishi J, Yazawa Y, Saito T, Shimizu M, Kawashima H, Ae K, Matsumine A, Torigoe T, Sugiura H, Joyama S. Atypical and malignant granular cell tumors in Japan; Japanese Musculoskeletal Oncology Group (JMOG) study. Int J Clin Oncol. 2016;21:808-16. doi: 10.1007/s10147-016-0949-1. 109) Gushima R, Yao T, Kurisaki-Arakawa A, Hara K, Hayashi T, Fukumura Y, Saito T, Arakawa A, Yao K, Sasaki Y. Expression of adipophilin in gastric epithelial neoplasia and its association with tumorigenesis. Virchows Archives. 2016, 468:169-177. 110) Hayashi T, Kumasaka T, Mitani K, Okada Y, Kondo T, Date H, Chen F, Oto T, Miyoshi S, Shiraishi T, Iwasaki A, Hara K, Saito T, Ando K, Kobayashi E, Gunji-Niitsu Y, Kunogi M, Takahashi K, Yao T, Seyama K. Bronchial involvement in advanced stage lymphangioleiomyomatosis: histopathologic and molecular analyses. Human Pathol. 2016, 50:34-42. 111) Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M, Kawasaki T, Matsuoka K, Akaikei K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K. An outpatient-based survey on the recognition of locomotive syndrome in Japan: The results of three years of surveys. Brit J Med Med Res 2016. 26127. 112) Mamat O, Fukumura Y, Saito T, Takahashi M, Mitomi H, Sai J, Kawasaki S, Yao T. Fundic gland differentiation of oncocytic/pancreatobiliary subtype of pancreatic of intraductal papillary mucinous neoplasms. Hitsopathology. 2016, 69(4):570-81. 113) Sato T, Okuda T, Saito T, Yonezawa I, Onda S, Shimamura Y, Yoshikawa K, Takano H, Kaneko K. A rare case of cervical dumbbell meningioma with the C2 spinous process preservation. Open J Orthopedics. 2016, 6(4):98-102. 114) Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T. Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab. PLoS One. 2016, 11(2):e0148401. 115) Toda-Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota D, Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T. Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors. Mod Pathol 2016; Nov;29(11):1424-1432. doi: 10.1038/modpathol.2016.138. 116) Tomomasa R, Akaike K, Asahina M, Toda-Ishii M, Yashiro D, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia. Int J Clin Exp Pathol, 2016;9:7230-7236. 117) Nasirden A, Saito T, Fukumura Y, Hara K, Akaike K, Kurisaki-Arakawa A, Asahina M, Yamashita A, Tomomasa R, Hayashi T, Arakawa A, Yao T. In Japanese patients with papillary thyroid carcinoma TERT promoter mutation is associated with poor prognosis, in contrast to BRAFV600E mutation. Virchows Arch 2016, 469: 687–696. 118) Suehara Y, Osawa H, Kubota D, Tanabe Y, Akaike K, Saito T, Kaneko K. Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy. J Bone Joint Surg Case connector. 2016, 6(3): e70 119) Kageyama S, Yamaguchi S, Ito S, Suehara Y, Saito T, Kitano S, Akaike K, Miura K , Kato S. Rapid Complete Treatment Response of a Melanoma Patient with Active Rheumatoid Arthritis. Int Cancer Conf J. (2016). doi:10.1007/s13691-016-0256-8. 120) Kim Y, Ishii M, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Okubo T, Kubota D, Saito T, Kaneko K. An orthopedic outpatient-based survey of locomotive syndrome using two screening tools (the “loco-check” and the “GLFS-25”) in Tokyo. British Journal of Medicine and Medical Research. 2016;17(5):1-13. ISSN: 2231-0614 121) Saito T, Akaike K, Tomomasa R, Suehara Y, Takagi T, Kaneko K, Yao T. A case of epithelioid hemangioma of the right third rib in a 55-year-old man. Int J Clin Exp Pathol. 2016;9(9):9681-9686. 122) Takamochi K, Omiya H, Itoh M, Mogushi K, Saito T, Hara K, Mitani K, Kogo Y, Yamanaka Y, Kawai J, Hayashizaki Y, Oh S, Suzuki K, Kawaji H. Novel biomarkers for accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung. BMC Cancer, 2016;16:760. 123) Jotatsu T, Yagishita S, Tajima K, Takahashi F, Mogushi K, Hidayat M, Wirawan A, Ko R, Kanemaru R, Shimada N, Mitani K, Saito T, Takamochi K, Suzuki K, Kohsaka S, Kojima S, Mukae H, Yatera K, Takahashi K. LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer. Biochemistry and Biophysics Reports, DOI: 10.1016/j.bbrep.2016.11.015 . 124) Yamashita A, Saito T, Akaike K, Arakawa A, Yoshida A, Kikuchi K, Sugitani M, Yao T. A case of mast cell sarcoma of the sternum clonally related to an antecedent germ cell tumor with a novel D579del KIT mutation. Virchows Arch, 2017 May;470(5):583-588. doi: 10.1007/s00428-017-2089-z. 125) Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Osada T, Watanabe S. Epigenetic regulation of Wnt/-catenin signal-associated genes in gastric neoplasia of the fundic gland (chief cell-predominant) type. Pathol Int. 2017, Jan 20. doi: 10.1111/pin.12509 126) Suehara Y, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K. Extensive callus formation due to a stress fracture of the first rib might have been associated with cerebral infarction in a young baseball player: A case report. JBJC connector, in press. 127) Hara K, Saito T, Hayashi T, Mitani K, Takamolchi K, Oh S, Suzuki K, Yao T. Inverse correlation between galectin-4 and TTF-1 in lung adenocarcinoma. Virchows Arch. 2017 Jul 19. doi: 10.1007/s00428-017-2202-3. 128) Tajima Y, Murakami T, Saito T, Hiromoto T, Akazawa Y, Sasahara N, Mitomi H, Yao T, Watanabe S. Distinct activation of sonic hedgehog signaling pathway between gastric adenocarcinoma of fundic gland type and conventional gastric adenocarcinoma. Digestion. 2017 Jul 22;96(2):81-91. doi: 10.1159/000478999. 129) Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T, Kaneko K, Ueno T, Kojima S, Kohashi K, Mano H, Oda Y, Yao T. Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. Human Pathol, in press. * equal contribution 130) Okamoto S, Komura M, Terao Y, Hayashi T, Saito T, Kurisaki A, Togo S, Shiokawa A, Mitani K, Kobayashi E, Kumasaka T, Takahashi K, Seyama K. Pneumothorax caused by cystic and nodular lung metastases from a malignant uterine perivascular epithelioid cell tumor (PEComa). Respir Med Case Rep. 2017 Jun 27;22:77-82. doi: 10.1016/j.rmcr.2017.06.011. eCollection 2017. 131) Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Sakamoto N, Osada T, Watanabe S. Distinct histopathological characteristics in colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp and conventional tubular adenoma. Virchow Archiv, 2017 Sep 19. doi: 10.1007/s00428-017-2234-8. 132) Anzai T, Saito T, Tsuyama S, Toh M, Ikeda K, Ito S. A Case of Glomangiopericytoma at the Nasal Septum. Head Neck Pathol. 2017 Nov 22. doi: 10.1007/s12105-017-0870-6. 133) Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T. IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma. Oncotarget, 2018; 9:14428-14443. https://doi.org/10.18632/oncotarget.24467. 134) Naito T, Saito T, Higuchi T, Inomata A, Hayashi T, Shimada Y, Yamauchi-Ohguchi A, Kenmochi S, Kakinuma C, Yao T. Dedifferentiated liposarcoma of retroperitoneum spontaneously occurred in aged SD rat. Journal of Toxicologic Pathology, in press. 135) Hayashi T, Takamochi K, Yanai Y, Mitani K, Tomita H, Mogushi K, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T. Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p40. Hum Pathol. 2018 Feb 1. pii: S0046-8177(18)30037-6. doi: 10.1016/j.humpath.2018.01.023. 136) Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M, Kondo T, Taguchi T, Kawai A, Takagi T, Kaneko K, Yao T, Saito T. KCTD12 may be negatively regulated by Kit in gastrointestinal stromal tumors. Oncotarget. 2018 Jun 5;9(43):27016-27026. doi: 10.18632/oncotarget.25469. eCollection 2018 Jun 5 137) Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: Emphasis on the relationship with hepatoid adenocarcinoma. Human Pathol. 2018 Aug;78:79-88. doi: 10.1016/j.humpath.2018.04.022. Epub 2018 May 8. 138) Akaike K, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Okubo T, Hayashi Y, Takamoch K, Takahashi F, Kaneko K, Saito T. PPP2R1A regulated by PAX3/FOXO3 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. Oncotarget. 2018 May 18;9(38):25206-25215. doi: 10.18632/oncotarget.25392. eCollection 2018 May 18. 139) Hiromoto T, Murakami T, Akazawa Y, Sasahara N, Saito T, Sakamoto N, Mitomi H, Nagahara A, Yao T. Immunohistochemical and genetic characteristics of a colorectal mucin-rich variant of traditional serrated adenoma. Histopatholoy. 2018 May 5. doi: 10.1111/his.13643 140) Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H. Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens. Cancer Sci. 2019 Apr;110(4):1464-1479. doi: 10.1111/cas.13968. Epub 2019 Mar 5. 141) Akazawa Y, Hayashi T, Saito T, Niwa K, Kamiyama H, Sasahara N, Sakamoto K, Nagahara A, Yao T. Histological characteristics of eosinophilic myenteric ganglionitis, an under-recognised cause of chronic intestinal pseudo-obstruction. Virchows Arch. 2019 Jan 4. doi: 10.1007/s00428-018-02513-5. 142) Asahina M, Fukumura Y, Mamat O, Saito T, Hayashi T, Fujii H, Uekusa T, Suzuki K, Yao T. A case of combined small cell lung carcinoma with unique morphology: investigation of tumorigenesis. Pathol Int. 2018;68:618-623. doi: 10.1111/pin.12726. 143) Toda-Ishii M, Suehara Y, Kohsaka S, Hayashi T, Kazuno S, Tanabe Y, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T. Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma. Oncotarget. 2018;9:37509-37519. doi: 10.18632/oncotarget.26493. 144) Asahina M, Saito T, Hayashi T, Fukumura Y, Mitani K, Yao T. Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features. Histopathology. 2019;74:514-525. doi: 10.1111/his.13759. 145) Kurihara T, Suehara Y, Akaike K, Hayashi T, Okubo T, Kim Y, Takagi T, Kaneko K, Yao T, Saito T. Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report. Human Pathology Case reports. 2019, June, 100289 146) Kato S, Hayashi T, Suehara Y, Hananoue H, Yamanaka S, Ichikawa Y, Higurashi T, Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T, Yao T, Nakajima A, Syed A, Zehir A, Ladanyi M, Kato S. Multicenter experience with large panel next generation sequencing in patients with advanced solid cancers in Japan. Jap J Clin Oncol, 2018 Dec 12. doi: 10.1093/jjco/hyy173. 147) Murakami T, Yoichi Akazawa Y, Yatagai N, Takafumi Hiromoto T, Sasahara N, Saito T, Sakamoto N, Nagahara A, Yao T. Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study. Diagnostic Pathol. 2018 Nov 20;13(1):88. doi: 10.1186/s13000-018-0771-3. 148) Yatagai N, Saito T, Akazawa Y, Hayashi T, Yanai Y, Tsuyama S, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. Frequent loss of heterozygosity of SMAD4 locus and prognostic impacts of SMAD4 immunohistochemistry in gastric adenocarcinoma with enteroblastic differentiation. Human Pathol. 2019 Jun;88:18-26. doi: 10.1016/j.humpath.2019.03.005. Epub 2019 Apr 1. 149) Yatagai N, Saito T, Akazawa Y, Hayashi T, Yanai Y, Tsuyama S, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation. Virchows Archiv. 2019 Mar;474(3):315-324. doi: 10.1007/s00428-018-2508-9. Epub 2018 Dec 15. 150) Suehara Y, Mukaihara K, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Keisuke Akaike K, Kim Y, Kaneko K, Saito T. Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone. PROTEOMICS - Clinical Applications. 2019 Jul 9:e1800147. doi: 10.1002/prca.201800147 151) Saito T, Motoi T, Suehara Y, Takagi T, Okubo T, Kurihara T, Hayashi T, Yanai Y, Kudo T, Maruyama Y, Kaneko K, Yao T. Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review. Human Pathol Case Reports. 2019, June, 100288. 152) Tsuyama S, Saito T, Akazawa Y, Yanai Y, Akaike K, Hayashi T, Suehara Y, Takahashi F, Takamochi K, Hashimoto T, Kajiyama Y, Tsurumaru M, Fukunaga T, Takashi Yao T. Molecular and clinicopathological analyses in esophageal carcinosarcoma with special reference on the differentiation mechanism. Virchows Archiv. 2019 Oct;475(4):415-424. doi: 10.1007/s00428-019-02643-4. Epub 2019 Aug 23. 153) Murakami T, Yao T, Yatagai N, Yamashiro Y, Saito T, Sakamoto N, Nagahara A. Colorectal adenocarcinoma with enteroblastic differentiation: A clinicopathological study of five cases. Histopathology. 2020 Jan;76(2):325-332. doi: 10.1111/his.13973. Epub 2019 Oct 30. 154) Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, Kojima S, Takeyama R, Hashimoto T, Kiyono T, Taguchi A, Tanaka T, Tanaka Y, Ikemura M, Sakata S, Takeuchi K, Muraoka A, Osuka S, Saito T, Oda K, Osuga Y, Terao Y, Kawazu M, Mano H. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations. Nat Comm. Dec 19;10(1):5785. doi: 10.1038/s41467-019-13708-y. 155) Nakahodo J, Fukumura Y, Saito T, Mitomi H, Saiura A, MD, Fujisawa T, Ishii S, Isayama H, Kurahayashi I, Yao T. Radiological and Pathological Assessment of the 2017 Revised International Association of Pancreatology Consensus Guidelines for Intraductal Papillary Mucinous Neoplasm, With an Emphasis on the Gastric Pyloric Gland Type. Pancreas. 2020 Feb;49(2):216-223. doi: 10.1097/MPA.0000000000001487. 156) Hasegawa N, Kohsaka S, Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H. Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter. Sci Rep. 2019 Dec 27;9(1):20047. doi: 10.1038/s41598-019-56377-z 157) Hayashi T, Takamochi K, Kohsaka S, Kishikawa S, Suehara Y, Takahashi F, Suzuki K, Saito T, Mano H, Yao T. Spontaneous transformation form EGFR/PTEN co-mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis. Pathol Int. in press. 158) Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Sano K, Sasa K, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H. Assessment of predictive biomarkers of the response to pazopanib based on an integrative analysis of high-grade soft-tissue sarcomas: Analysis of a tumor sample from a responder and patients with other soft-tissue sarcomas. Clin Orthop Relat Res, in press. 159) Yanai Y, Hayashi T, Akazawa Y, Yatagai N, Tsuyama S, Yao T, Saito T. Clinicopathological and mutational differences between tumors with multiple metastases and single lung metastasis in colorectal cancer. Oncol letter, in press. 160) Yamashiro Y, Saito T, Hayashi T, Murakami T, Yanai Y, Tsuyama S, Suehara Y, PhD, Takamochi K, Yao T. Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation. Histopathology, in press. doi: 10.1111/his.14158. 161) Nakahodo J, Fukumura Y, Saito T, Hirabayashi K, Doi R, Hayashi T, Yao T. Upregulation of follistatin and low apoptotic activity in intraductal oncocytic papillary neoplasm of the pancreatobiliary system. Sci Repl, 2020, 10(1): 8179. doi: 10.1038/s41598-020-64920-6. 162) Asahina M, Hayashi T, Takamochi K, Saito T, Onagi H, Kishi M, Fukumura Y, Arakawa A, Suzuki K, Yao T. Identification of CTNNB1-PLAG1 gene rearrangement in a patient with pulmonary pleomorphic adenoma. Virchows Archiv, in press. Apr 19. doi: 10.1007/s00428-020-02810-y. 163) Sano K, Suehara Y, Okubo T, Sasa K, Kurihara T, Akaike K, Kubota D, Torigoe T, Hasegawa N, Ishii M, Kim Y, Takagi T, Kaneko K, Hayashi T, Saito T. Preoperative denosumab treatment with curettage maybe a risk factor for recurrence of giant cell tumor of bone. J Ortho Surg (Hong Kong). 2020 Jan-Apr;28(2):2309499020929786. doi: 10.1177/2309499020929786. 164) Tsuyama S, Kohsaka S, Hayashi T, Suehara Y, Hashimoto T, Kajiyama Y, Tsurumaru M, Ueno T, Mano H, Yao T, Saito T. Comprehensive analysis of the molecular and clinical characteristics of primary malignant melanoma of the esophagus. Histopathology, in press. 165) Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, Yao T. Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations. Human Pathol, in press. 166) Yanai Y, Saito T, Hayashi T, Akazawa Y, Yatagai N, Tsuyama S, Tomita S, Hirai S, Ogura K, Matsumoto T, Wada R, Yao T. Transition of low-grade appendiceal mucinous neoplasm to mucinous adenocarcinoma: A clinicopathological/comprehensive analysis. Virchows Arch. 2020 Aug 21. doi: 10.1007/s00428-020-02906-5. Online ahead of print.

研究テーマ

悪性腫瘍における臨床病理学的・分子病理学的解析

研究業績（論文）

1) Oda Y, Sakamoto A, Saito T, Kinukawa N, Iwamoto Y, Tsuneyoshi M. Expression of hepatocyte growth factor (HGF)/scatter factor and its receptor c-MET correlates with poor prognosis in synovial sarcoma. Hum Pathol. 2000, 31:185-92.
2) Kawauchi S, Fukuda T, Oda Y, Saito T, Oga A, Takeshita M, Yokoyama K, Chuman H, Iwamoto Y, Sasaki K, Tsuneyoshi M. Prognostic significance of apoptosis in synovial sarcoma: correlation with clinicopathologic parameters, cell proliferative activity, and expression of apoptosis-related proteins. Mod Pathol. 2000, 13:755-765, 2000
3) Oda Y, Sakamoto A, Saito T, Kawauchi S, Iwamoto Y, Tsuneyoshi M. Molecular abnormalities of p53, MDM2, and H-ras in synovial sarcoma. Mod Pathol. 13:994-1004, 2000.
4) Saito T, Oda Y, Sakamoto A, Tamiya S, Kinukawa N, Hayashi K, Iwamoto Y, Tsuneyoshi M. Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of -catenin mutation in synovial sarcoma. J Pathol. 2000, 192:342-350.
5) Shiratsuchi H, Oshiro Y, Saito T, Itakura E, Kinoshita Y, Tamiya S, Oda Y, Komiyama S, Tsuneyoshi M. Cytokeratin subunits of inclusion bodies in rhabdoid cells: Immunohistochemical and clinicopathological study of malignant rhabdoid tumor and epithelioid sarcoma. Int J Surg Pathol. 2001, 9:37-48.
6) Adachi T, Oda Y, Sakamoto A, Saito T, Tamiya S, Masuda K, Tsuneyoshi M. Immunoreactivity of p53, mdm2, and p21WAF1 in dedifferentiated liposarcoma: special emphasis on distinct immunophenotype in well-differentiated component. Int J Surg Pathol. 2001, 9:99-109.
7) Oda Y, Sakamoto A, Saito T, Matsuda S, Tanaka K, Iwamoto Y, Tsuneyoshi M. Secondary malignant giant-cell tumor of bone: Molecular abnormalities of p53 and H-ras gene correlated with malignant transformation. Histopathology 2001, 39:629-637.
8) Saito T, Oda Y, Itakura E, Shiratuchi H, Kinoshita Y, Oshiro Y, Tamiya S, Hachitanda Y, Iwamoto Y, Tsuneyoshi M. Expression of intercellular adhesion molecules in epithelioid sarcoma and malignant rhabdoid tumor. Pathol Int. 2001, 51:532-42.
9) Saito T, Oda Y, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M. -catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumors. J Pathol. 2001, 195:222-228.
10) Saito T, Oda Y, Sugimachi K, Kawaguchi K, Tamiya S, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y, Tsuneyoshi M. E-cadherin gene mutations frequently occur in synovial sarcoma as a determinant of histological features. Am J Pathol. 2001, 159:2117-2124.
11) Saito T, Oda Y, Kawaguchi K, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M. Possible Association between Higher -catenin mRNA Expression and Mutated -catenin in Sporadic Desmoid Tumors: Real-Time Semiquantitative Assay by TaqMan Polymerase Chain Reaction. Lab Invest. 2002, 82:97-103.
12) Shiratsuchi H, Saito T, Sakamoto A, Itakura E, Tamiya S, Oshiro Y, Oda Y, Toh S, Komiyama S, Tsuneyoshi M.　Mutation analysis of human cytokeratin 8 (KRT 8) gene in malignant rhabdoid tumor: A possible contribution to intracytoplasmic inclusion body formation. Mod Pathol. 2002, 15:146-153.
13) Saito T, Oda Y, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characteristics in synovial sarcoma. Histopathology. 2002, 40:279-285.
14) Saito T, Oda Y, Sakamoto A, Kawaguchi K, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y, Tsuneyoshi M. APC mutations in synovial sarcoma. J Pathol. 2002, 196:445-449.
15) Kawaguchi K, Oda Y, Nakanishi K, Saito T, Tamiya S, Nakahara K, Matsuoka H, Tsuneyoshi M. Malignant Transformation of Renal Angiomyolipoma: A Case Report. Am J Surg Pathol. 2002, 26:523-529.
16) Kawaguchi K, Oda Y, Sakamoto A, Saito T, Tamiya S, Iwamoto Y, Tsuneyoshi M. Molecular analysis of p53, MDM2 and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. Mod Pathol. 2002, 15:878-888.
17) Sakamoto A, Oda Y, Adachi T, Saito T, Matsuda S, Tanaka K, Oshiro Y, Tamiya S, Iwamoto Y, Tsuneyoshi M. -catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytoma. Arch Pathol Lab Med. 2002, 126:1071-1078.
18) Oda Y, Ohishi Y, Saito T, Hinoshita E, Uchiumi T, Kinukawa N, Iwamoto Y, Kohno K, Kuwano M, Tsuneyoshi M. Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma. J Pathol. 2003, 199:251-258.
19) Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Tanaka K, Matsuda S, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcoma without specific balanced translocations. Int J Cancer. 2003, 104:175-178.
20) Yamamoto H, Oda Y, Saito T, Sakamoto A, Miyajima K, Tamiya S, Nakamori M, Tsuneyoshi M. p53 mutation and MDM2 amplification in inflammatory myofibroblastic tumours. Histopathology. 2003, 42:431-439.
21) Saito T, Oda Y, Kawaguchi K, Takahira T, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. Possible asociation between tumor suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma. Hum Pathol. 2003, 34:841-849.
22) Adachi T, Oda Y, Sakamoto A, Saito T, Tamiya S, Hachitanda Y, Masuda S, Tsuneyoshi M. Mixed tumor of deep soft tissue. Pathol Int. 2003, 53:35-39.
23) Saito T, Oda Y, Tanaka K, Matsuda S, Sakamoto A, Yamamoto H, Iwamoto Y, Tsuneyoshi M. Low-grade fibrosarcoma of the proximal humerus. Pathol Int. 2003, 53:115-120.
24) Kawaguchi K, Oda Y, Saito T, Yamamoto H, Tamiya S, Takahira T, Miyajima K, Iwamoto Y, Tsuneyoshi M. Mechanism of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor prognosis. J Pathol. 2003, 201:487-495.
25) Kawaguchi K, Oda Y, Saito T, Tamiya S, Yamamoto H, Tanaka K, Matsuda S, Iwamoto Y, Tsuneyoshi M. Decreased Expression of TGF- II Receptor Associates with that of p27KIP1 in Giant Cell Tumor of Bone: The Correlation Between TGF- Receptors and Cell Cycle-related Proteins. Hum Pathol. 2004, 35:61-68.
26) Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Tamiya S, Iwamoto Y, Tsuneyoshi M. Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression. Hum Pathol. 2004, 35:1266-1271.
27) Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, Saito T, Oshiro Y, Ohta M, Yao T, Tsuneyoshi M. c-kit and PDGFRA Mutations in Extragastrointestinal Stromal Tumor (Gastrointestinal stromal tumor of the soft part). Am J Surg Pathol. 2004, 28:479-488.
28) Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Tanaka K, Matsuda S, Sakamoto A, Tamiya S, Iwamoto Y, Tsuneyoshi M. PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcoma. Oncol Rep.2004, 11:1011-1015.
29) Saito T, Oda Y, Kawaguchi K, Yamamoto H, Sugimachi K, Tateishi N, Tanaka K, Matsuda S, Iwamoto Y, Ladanyi M, Tsuneyoshi M. E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma. Oncogene. 2004, 23:8629-8638.
30) Oda Y, Saito T, Tateishi N, Ohishi Y, Tamiya S, Yamamoto H, Yokoyama R, Uchiumi T, Iwamoto Y, Kuwano M, tsuneyoshi M. ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcomas. Int J Cancer. 2005, 114:854-862.
31) Saito T, Oda Y, Kawaguchi K, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y, Tsuneyoshi M. Five-year evolution of a telangiectatic osteosarcoma initially managed as an aneurismal bone cyst. Skeletal Radiol 2005, 34:290-294.
32) Kawaguchi K, Oda Y, Takahira T, Saito T, Yamamoto H, Kobayashi C, Tamiya S, Oda S, Iwamoto Y, Tsuneyoshi M. Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomas. Oncol Rep 2005, 13:241-246.
33) Kawaguchi K, Oda Y, Saito T, Takahira T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M. Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas. Hum Pathol. 2005, 36:357-63.
34) Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Kobayashi C, Tamiya S, Tateishi N, Iwamoto Y, Tsuneyoshi M. DNA hypermethylation status of multiple genes in soft tissue sarcomas. Mod Pathol. 2006, 19:106-114.
35) Saito T, Oda Y, Yamamoto H, Kawaguchi K, Tanaka K, Matsuda S, Iwamoto Y, Tsuneyoshi M. Nuclear -catenin correlates with cyclin D1 expression in spindle and pleomorphic sarcomas but not in synovial sarcoma. Hum Pathol. 2006, 37:689-697.
36) Izumi T, Hasegawa T, Nakanishi Y, Iwasaki H, Sonobe H, Goto H, Kusakabe H, Takahira T, Kobayashi T, Kawaguchi K, Saito T, Yamamoto H, Tamiya S, Iwamoto Y, Tsuneyoshi M. Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor. Mod Pathol. 2006, 19:820-831.
37) Saito T, Nagai M, Ladanyi M. SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by Snail and Slug. A potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma. Cancer Res. 2006, 68:6919-6927.
38) Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR, Downs-Kelly E, Corless CL, Rubin BP, van de Rijn M, Ladanyi M, Nielsen TO. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies. Am J Surg Pathol. 2007, 31:240-246.
39) Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Lae M, Fisher DE, Ladanyi M. TFE3 fusions activates MET signaling by the transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res. 2007, 67:919-929.
40) Shiratsuchi H, Nakashima T, Hirakawa N, Toh S, Nakagawa T, Saito T, Tsuneyoshi M, Komune S. beta-catenin nuclear accumulation in head and neck mucoepidermoid carcinoma: its role in cyclin D1 expression and tumor progression. Head Neck. 2007, 29:577-584.
41) Matono H, Oda Y, Nakamori M, Tamiya S, Yamamoto H, Yokoyama R, Saito T, Iwamoto Y, Tsuneyoshi M. Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoids tumors. Hum Pathol. 2008, 39:1802-1808.
42) Mitomi H, Fukui N, Tanaka N, Kanazawa H, Saito T, Matsuoka T, Yao T. Aberrant p16(INK4a) methylation is a frequent event in colorectal cancers: prognostic value and relation to mRNA expression and immunoreactivity. J Cancer Res Clin Oncol. 2010, 136:323-331.
43) Barretina J, Taylor BS, Banerji S, Ramos AH, Lagos-Quintana M, Decarolis PL, Shah K, Socci ND, Weir BA, Ho A, Chiang DY, Reva B, Mermel CH, Getz G, Antipin Y, Beroukhim R, Major JE, Hatton C, Nicoletti R, Hanna M, Sharpe T, Fennell TJ, Cibulskis K, Onofrio RC, Saito T, Shukla N, Lau C, Nelander S, Silver SJ, Sougnez C, Viale A, Winckler W, Maki RG, Garraway LA, Lash A, Greulich H, Root DE, Sellers WR, Schwartz GK, Antonescu CR, Lander ES, Varmus HE, Ladanyi M, Sander C, Meyerson M, Singer S. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet. 2010, 42:715-721.
44) Yokotsuka M, Iwaya K, Saito T, Pandiella A, Tsuboi R, Kohno N, Matsubara O, Mukai K. Overexpression of HER2 signaling to WAVE2–Arp2/3 complex activates MMP-independent migration in breast cancer. Breast Cancer Res Treat 2011, 126:311-318.
45) Saito T, Mitomi H, Izumi H, Suehara Y, Torigoe T, Takagi T, Kaneko K, Sato K, Matsumoto T, Yao T. A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-time follow-up. Human Pathol, 2011, 42:727-733.
46) Matono H, Tamiya S, Yokoyama R, Saito T, Iwamoto Y, Tsuneyoshi M, Oda Y. Abnormalities of Wnt/-catenin signaling pathway induce tumor progression in sporadic desmoids tumors: correlation between -catenin widespread nuclear expression and VEGF overexpression. Histopathology. 2011, 59:368-375.
47) Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T, Yao T. Cluster analysis of claudin-1 and -4, E-cadherin and -catenin expression in colorectal cancers. J Surg Oncol. 2011, 103:674-686.
48) Mitomi H, Fukui N, Kishimoto I, Tanabe S, Kikuchi S, Saito T, Hayashi T, Yao T. Role for p16(INK4a) in progression of gastrointestinal stromal tumors of the stomach: alteration of p16(INK4a) network members. Human Pathol. 2011, 42:1505-1513.
49) Fujimaki M, Fukumura Y, Saito T, Mitani K, Uchida S, Yokoyama J, Yao T, Ikeda K. Oncocytic mucoepidermoid carcinoma of the parotid gland with CRTC1-MAML2 fusion transcript: report of a case with review of literature. Human Pathol. 2011, 42:2052-2055.
50) Saito T, Mitomi H, Suehara Y, Okubo T, Torigoe T, Takagi T, Kaneko K, Yao T. A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. Pathol Res Pract, 2011, 207:664-669.
51) Torigoe T, Tomita Y, Iwase Y, Aritomi K, Suehara Y, Oukubo T, Sakurai A, Terakado A, Takagi T, Kaneko K, Saito T, Yazawa Y. Reconstruction using frozen autograft bone treated by liquid nitrogen for malignant bone tumor in the forearm: A new technique of pedicle freezing. J Ortho Surg. 2012, 20:98-102.
52) Yonezawa I, Saito T, Nakahara D, Won J, Wada T, Kaneko K. Synovial sarcoma of the cauda equina. J Neurosurg Spine. 2012, 16:187-190.
53) Imamhasan A, Mitomi H, Saito T, Arakawa A, Yao T. Clear cell variant of squamous cell carcinoma originating in the esophagus: Report of a case with immunohistochemical and oncogenetic analyses. Pathol Int. 2012, 62:137-143.
54) Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Yao T, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T. Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor. J Proteomics. 2012, 75:1089-1098.
55) Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Katagiri H, Murata H, Takahashi M, Ito I, Yao T, Kaneko K. Intraneural lipomatous tumor of median nerve: Report of 3 cases with literature review. Int J Surg Case Rep. 2012, 3:407-411.
56) Imamhasan A, Mitomi H, Saito T, Hayashi T, Takahashi M, Kajiyama Y, Yao T. Immunohistochemical and oncogenetic analyses of the esophageal basaloid squamous cell carcinoma in comparison with conventional squamous cell carcinomas. Human Pathol. 2012, 43:2012-2023.
57) Nakae K, Mitomi H, Saito T, Takahashi M, Morimoto T, Hidaka Y, Sakamoto N, Yao T, Watanabe S. MUC5AC/β-catenin expression and K-ras gene altered in laterally spreading colorectal tumors. World J Gastroenterol. 2012, 18:5551-5559.
58) Hayashi T, Koike K, Kumasaka T, Saito T, Mitani K, Terao Y, Ogishima D, Yao T, Takeda S, Takahashi K, Seyama K. Uterine angiosarcoma associated with lymphangioleiomyomatosis in a patient with tuberous sclerosis complex：An autopsy case report with immunohistochemical and genetic analysis. Human Pathol. 2012, 43:1777-1784.
59) Kubota D, Okubo T, Saito T, Suehara Y, Yoshida A, Kikuta K, Tsuda H, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T. Validation Study on Pfetin and ATP-dependent RNA helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumor. Jpn J Clin Oncol 2012, 42:730-741.
60) Saito T, Mitomi H, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Malignant granular cell tumor with unusual long clinical course. An autopsy case with review of literatures. J Cancer Sci Ther. 2012, 4:260-263.
61) Saito T, Yokotsuka M, Motoi T, Iwasaki H, Nagao T, Ladanyi M, Yao T. EWS-WT1 chimeric protein in desmoplastic small round cell tumor is a potent transactivator of FGFR4. J Cancer Sci Ther. 2012, 4:335-340.
62) Ho AL, Vasudeva SD, Barbashina V, Laé M, Saito T, Antonescu C, Ladanyi M, Schwartz GK. PDGFRA is an alternative mediator of Rapamycin-Induced Akt Activation in Synovial Sarcoma: implications for combination targeted therapy. Cancer Res 2012, 72:4515-4525.
63) Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Yao T, Kaneko K. Possible involvement of p53 genetic alteration associated with protein overexpression in malignant transformation of giant-cell tumor of bone. Virchows Archiv 2013, 63:67-77.
64) Suehara Y, Kubota D, Saito T. Tissue Sample Preparation for Biomarker Discovery. Methods Mol Biol. 2013, 1002:13-23.
65) Alkam Y, Mitomi H, Nakai K, Himuro T, Saito T, Takahashi M, Arakawa A, Yao T, Saito M. Protein expression and methylation of DNA repair genes hMLH1, hMSH2, MGMT and BRCA1 and their correlation with clinicopathological parameters and prognosis in basal-like breast cancer. Histopathology. 2013, 63:713-725.
66) Hidaka Y, Mitomi H, Saito T, Takahashi M, Lee SY, Matsumoto K, Yao T, Watanabe S. Alteration in the Wnt/β-catenin signaling pathway in gastric neoplasias of fundic gland (chief cell predominant) type. Human Pathol. 2013, 44:2438-2448.
67) Hayashi T, Saito T, Fujimura T, Hara K, Takamochi K, Mitani K, Mineki R, Kazuno S, Oh S, Suzuki K, Ueno T, Suzuki K, Yao T. Galectin-4, a novel predictor for lymph node metastasis in lung adenocarcinoma: A proteomic study. PLoS One. 2013, 8:e81883.
68) Hamano A, Suzuki T, Saito T, Kuwatsuru R, Oh S, Suzuki K. Infiltrative angiolipoma of the thoracic wall: A case report. Open J Clin Diag. 2013, 3:19-22.
69) Saito T, Mitomi H, Kurisaki A, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Low-grade myofibroblastic sarcoma of the distal femur. Int J Surg Case Rep. 2013, 4:195-199.
70) Kobos R, Nagai M, Tsuda M, Lui MY, Saito T, Laé M, Mo Q, Olshen A, Lianoglou S, Leslie C, Shao Y, Antczak C, Djaballah H, Ladanyi M. A combined integrated genomics / functional genomics strategy to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein. J Pathol. 2013, 229:743-754.
71) Kubota D, Yoshida A, Tsuda H, Suehara Y, Okubo T, Saito T, Orita H, Sato K, Taguchi T, Yao T, Kaneko K, Katai H, Kawai A, Kondo T. Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor. PLoS One. 2013, 8:e73896.
72) Kubota D, Mukaihara K, Yoshida A, Suehara Y, Saito T, Okubo T, Gotoh M, Orita H, Tsuda H, Kaneko K, Kawai A, Kondo T, Sato K, Yao T. The prognostic value of pfetin: a validation study in gastrointestinal stromal tumors using a commercially available antibody. Jpn J Clin Oncol. 2013, 43:669-675.
73) Saito T, Ryu M, Fukumura Y, Asahina M, Arakawa A, Nakai K, Miura H, Saito M, Yao T. A case of myxoid liposarcoma of the breast. Int J Clin Exp Pathol. 2013, 6:1432-1436.
74) Okubo T, Saito T, Takagi T, Torigoe T, Suehara Y, Akaike K, Yao T, Kaneko K. Desmoplastic fibroma of the scapula with uptake of FDG-PET: A case report with review of literature. Int J Clin Exp Pathol. 2013, 6:2230-2236.
75) Kurisaki-Arakawa A, Saito T, Takahashi M, Mitani K, Fukumura Y, Nagashima Y, Argani P, Yao T. A case of bilateral renal cell carcinoma associated with long-term dialysis showing false-positive immunoreactivity for TFE3. Int J Clin Exp Pathol, 2013, 6:2585-2590.
76) Saito T. Review: SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling. Int J Clin Exp Pathol, 2013, 6:2272-2279.
77) Suehara Y, Kohsaka S, Kubota D, Mukaihara K, Akaike K, Mineki R, Fujimura T, Ladanyi M, Saito T, Kondo T. Review: Proteomic technologies to develop biomarkers and functional analyses in the bone and soft tissue tumors. J Proteo Bioinf, 2013 S3: 1-13.
78) Saito T, Mitomi H, Imamhasan A, Hayashi T, Mitani K, Takahashi M, Kajiyama Y, Yao T. Downregulation of sFRP-2 by epigenetic silencing activates the -catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. Virchows Arch 2014, 464:135-143. 79) Morimoto T, Mitomi H, Saito T, Takahashi M, Murakami T, Sakamoto N, Yao T, Watanabe S. Distinct profile of HIF1α, PTCH, EphB2 or DNA repair protein expression and BRAF mutation in colorectal serrated adenomas. J Gastroenterology and Hepatology. 2014, 29:1192-1199.
80) Toda M, Suehara Y, Akaike K, Okubo T, Kubota D, Mukaihara K, Kaneko K, Yao T, Takagi T, Saito T. Giant-cell tumor of bone arising in the anterior chest wall with positive expressions of GPX-1: a case report with review of literature. Int Canc Conf J. 2014, 3:178-182.
81) Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K. Desmoplastic fibroma of the rib with cystic change : a case report and literature review. Skeletal Radiol 2014, 43:703-708.
82) Okubo T, Suehara Y, Kawasaki T, Akaike K, Toda M, Okubo N, Kubota D, Mukaihara K, Kim Y, Kaketa T, Homma Y, Shimanouchi N, Saito T, Takagi T, Kaneko K. An outpatient-based survey about the recognition of locomotive syndrome and the results of the loco-check at a university hospital in Tokyo. Brit J Med Med Res, 2014, 4:3255-3268.
83) Masuda Y, Kurisaki-Arakawa A, Hara K, Arakawa A, Oh S, Suzuki K, Yao T, Saito T. A case of dedifferentiated solitary fibrous tumor of thoracic cavity. Int J Clin Exp Pathol, 2014, 7:386-393.
84) Shiono S, Saito T, Fujii H, Arakawa A, Nakamura T, Yao T. A case of Krukenberg carcinoma metastasized from colon cancer resembling mucinous cystadenocarcinoma of the ovary. Int J Clin Exp Pathol, 2014, 7:394-401.
85) Akaike K, Suehara Y, Takagi T, Kaneko K, Saito T. Eggshell-like mineralized recurrent lesion in the popliteal region after treatment of giant cell tumor of bone with denosumab. Skeletal Radiol 2014, 43:1767-1772.
86) Kurisaki-Arakawa A, Saito T, Takahashi M, Mitani K, Yao T. A case of 123I-MIBG scintigram-negative functioning pheochromocytoma: Immunohistochemical and molecular analysis with review of literature. Int J Clin Exp Pathol. 2014, 7:4438-4447.
87) Kurisaki-Arakawa A, Akaike K, Hara K, Arakawa A, Takahashi M, Mitani K, Yao T, Saito T. A case of dedifferentiated solitary fibrous tumor in the pelvis with TP53 mutation. Virchows Arch 2014, 465:615-621.
88) Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T. Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy. Diagn Pathol. 2014, 9:163.
89) Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S Kaneko K, Horie S, Yao T. A case of primary spindle cell variant of rhabdomyosarcoma of the prostate in Young Adult. Int J Clin Exp Pathol, 2014, 7:5181-5185..
90) Nomura R, Saito T, Mitomi H, Hidaka Y, Lee SY, Watanabe S, Yao T. GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. Human Pathol. 2014, 45:2488-2496.
91) Kurisaki-Arakawa A, Akaike K, Tomomasa R, Arakawa A, Suehara Y, Takagi T, Kaneko K, yao T, Saito T. A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion. Int J Surg Case Rep. 2014, 5:1123-1127.
92) Murakami T, Mitomi H, Saito T, Takahashi M, Sakamoto N, Fukui N, Yao T, Watanabe S. Distinct Wnt/-catenin signaling activation in the serrated neoplasia pathway and the adenoma-carcinoma sequence of the colorectum. Mod Pathol. 2015, 28:146-158.
93) Saito T, Mitomi H, Imamhasan A, Hayashi T, Kurisaki-Arakawa A, Mitani K, Takahashi M, Kajiyama Y, Yao T. PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma. Mutagenesis. 2015, 30:297-301.
94) Inaba T, Fukumura Y, Saito T, Yokoyama J, Ohba S, Yao T. Cytological features of mammary analogue secretary carcinoma of the parotid gland: A case report and review of the literature. Case Rep Pathol. 2015;2015:656107.
95) Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T. Distinct clinicopathologic features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. Human Pathol. 2015, 46:347-356.
96) Lee SY, Saito T, Mitomi H, Hidaka Y, Murakami T, Nomura R, Watanabe S, Yao T. Mutation spectrum of Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps. Virchows Arch. 2015, 467:27-38
97) Saito T, Mitomi H, Yao T. Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. Int J Clin Exp Pathol. 2015, 8:2267-2273.
98) Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur. In J Clin Exp Pathol. 2015, 8:3270-3278.
99) Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T. Spindle cell lipoma of the wrist, occurring in a distinctly rare location: A case report with review of literature. Int J Clin Exp Pathol. 2015, 8:3299-3303.
100) Hara K, Saito T, Hayashi T, Yimit A, Takahashi M, Mitani K, Takahashi M, Yao T. A mutation spectrum that includes GNAS, KRAS, and TP53 may be shared by mucinous neoplasms of the appendix. Pathol Res Pract. 2015, 21:657-664.
101) Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K , Saito T. Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases. PLoS One. 2015, 10:e0129428.
102) Hara K, Fukumura Y, Saito T, Arakawa A, Okabe H, Takeda S, Yao T. A giant cord hemangioma with extramedullary hematopoiesis and elevated maternal serum human chorionic gonadotropin: A case report and review of the literature. Diagn Pathol. 2015, 10:154.
103) Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T. TERT promoter mutations are a rare event in gastrointestinal stromal tumors. SpringerPlus. 2015, 4:836.
104) Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K. The Recognition of Locomotive Syndrome in 2014: A Cross-Sectional Study in the Orthopeadic Outpatients in Tokyo. Brit J Med Med Res 2015. 14207.
105) Murakami T, Yao T, Mitomi H, Morimoto T, Ueyama H, Matsumoto K, Saito T, Osada T, Nagahara A, Watanabe S. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric Cancer.　2016, 19:498-507.
106) Saito T, Akaike K, Kurisaki-Arakawa A, Toda-Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T. TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients. Mol Clin Oncol. 2016, 4:61-64.
107) Mukaihara K, Suehara Y, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi M, Kaneko K, Saito T. Expression of F-actin-capping protein subunit beta, CAPZB, is associated with cell growth and motility in epithelioid sarcoma. BMC Cancer. 2016, 16:206.
108) Imanishi J, Yazawa Y, Saito T, Shimizu M, Kawashima H, Ae K, Matsumine A, Torigoe T, Sugiura H, Joyama S. Atypical and malignant granular cell tumors in Japan; Japanese Musculoskeletal Oncology Group (JMOG) study. Int J Clin Oncol. 2016;21:808-16. doi: 10.1007/s10147-016-0949-1.
109) Gushima R, Yao T, Kurisaki-Arakawa A, Hara K, Hayashi T, Fukumura Y, Saito T, Arakawa A, Yao K, Sasaki Y. Expression of adipophilin in gastric epithelial neoplasia and its association with tumorigenesis. Virchows Archives. 2016, 468:169-177.
110) Hayashi T, Kumasaka T, Mitani K, Okada Y, Kondo T, Date H, Chen F, Oto T, Miyoshi S, Shiraishi T, Iwasaki A, Hara K, Saito T, Ando K, Kobayashi E, Gunji-Niitsu Y, Kunogi M, Takahashi K, Yao T, Seyama K. Bronchial involvement in advanced stage lymphangioleiomyomatosis: histopathologic and molecular analyses. Human Pathol. 2016, 50:34-42.
111) Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M, Kawasaki T, Matsuoka K, Akaikei K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K. An outpatient-based survey on the recognition of locomotive syndrome in Japan: The results of three years of surveys. Brit J Med Med Res 2016. 26127.
112) Mamat O, Fukumura Y, Saito T, Takahashi M, Mitomi H, Sai J, Kawasaki S, Yao T. Fundic gland differentiation of oncocytic/pancreatobiliary subtype of pancreatic of intraductal papillary mucinous neoplasms. Hitsopathology. 2016, 69(4):570-81.
113) Sato T, Okuda T, Saito T, Yonezawa I, Onda S, Shimamura Y, Yoshikawa K, Takano H, Kaneko K. A rare case of cervical dumbbell meningioma with the C2 spinous process preservation. Open J Orthopedics. 2016, 6(4):98-102.
114) Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T. Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab. PLoS One. 2016, 11(2):e0148401.
115) Toda-Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota D, Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T. Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors. Mod Pathol 2016; Nov;29(11):1424-1432. doi: 10.1038/modpathol.2016.138.
116) Tomomasa R, Akaike K, Asahina M, Toda-Ishii M, Yashiro D, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia. Int J Clin Exp Pathol, 2016;9:7230-7236.
117) Nasirden A, Saito T, Fukumura Y, Hara K, Akaike K, Kurisaki-Arakawa A, Asahina M, Yamashita A, Tomomasa R, Hayashi T, Arakawa A, Yao T. In Japanese patients with papillary thyroid carcinoma TERT promoter mutation is associated with poor prognosis, in contrast to BRAFV600E mutation. Virchows Arch 2016, 469: 687–696.
118) Suehara Y, Osawa H, Kubota D, Tanabe Y, Akaike K, Saito T, Kaneko K. Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy. J Bone Joint Surg Case connector. 2016, 6(3): e70
119) Kageyama S, Yamaguchi S, Ito S, Suehara Y, Saito T, Kitano S, Akaike K, Miura K , Kato S. Rapid Complete Treatment Response of a Melanoma Patient with Active Rheumatoid Arthritis. Int Cancer Conf J. (2016). doi:10.1007/s13691-016-0256-8.
120) Kim Y, Ishii M, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Okubo T, Kubota D, Saito T, Kaneko K. An orthopedic outpatient-based survey of locomotive syndrome using two screening tools (the “loco-check” and the “GLFS-25”) in Tokyo. British Journal of Medicine and Medical Research. 2016;17(5):1-13. ISSN: 2231-0614
121) Saito T, Akaike K, Tomomasa R, Suehara Y, Takagi T, Kaneko K, Yao T. A case of epithelioid hemangioma of the right third rib in a 55-year-old man. Int J Clin Exp Pathol. 2016;9(9):9681-9686.
122) Takamochi K, Omiya H, Itoh M, Mogushi K, Saito T, Hara K, Mitani K, Kogo Y, Yamanaka Y, Kawai J, Hayashizaki Y, Oh S, Suzuki K, Kawaji H. Novel biomarkers for accurate discrimination of squamous cell carcinoma from adenocarcinoma of the lung. BMC Cancer, 2016;16:760.
123) Jotatsu T, Yagishita S, Tajima K, Takahashi F, Mogushi K, Hidayat M, Wirawan A, Ko R, Kanemaru R, Shimada N, Mitani K, Saito T, Takamochi K, Suzuki K, Kohsaka S, Kojima S, Mukae H, Yatera K, Takahashi K. LSD1/KDM1 isoform LSD1+8a contributes to neural differentiation in small cell lung cancer. Biochemistry and Biophysics Reports, DOI: 10.1016/j.bbrep.2016.11.015 .
124) Yamashita A, Saito T, Akaike K, Arakawa A, Yoshida A, Kikuchi K, Sugitani M, Yao T. A case of mast cell sarcoma of the sternum clonally related to an antecedent germ cell tumor with a novel D579del KIT mutation. Virchows Arch, 2017 May;470(5):583-588. doi: 10.1007/s00428-017-2089-z.
125) Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Osada T, Watanabe S. Epigenetic regulation of Wnt/-catenin signal-associated genes in gastric neoplasia of the fundic gland (chief cell-predominant) type. Pathol Int. 2017, Jan 20. doi: 10.1111/pin.12509
126) Suehara Y, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K. Extensive callus formation due to a stress fracture of the first rib might have been associated with cerebral infarction in a young baseball player: A case report. JBJC connector, in press.
127) Hara K, Saito T, Hayashi T, Mitani K, Takamolchi K, Oh S, Suzuki K, Yao T. Inverse correlation between galectin-4 and TTF-1 in lung adenocarcinoma. Virchows Arch. 2017 Jul 19. doi: 10.1007/s00428-017-2202-3.
128) Tajima Y, Murakami T, Saito T, Hiromoto T, Akazawa Y, Sasahara N, Mitomi H, Yao T, Watanabe S. Distinct activation of sonic hedgehog signaling pathway between gastric adenocarcinoma of fundic gland type and conventional gastric adenocarcinoma. Digestion. 2017 Jul 22;96(2):81-91. doi: 10.1159/000478999.
129) Kohsaka S*, Saito T*, Akaike K, Suehara Y, Hayashi T, Takagi T, Kaneko K, Ueno T, Kojima S, Kohashi K, Mano H, Oda Y, Yao T. Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. Human Pathol, in press. * equal contribution
130) Okamoto S, Komura M, Terao Y, Hayashi T, Saito T, Kurisaki A, Togo S, Shiokawa A, Mitani K, Kobayashi E, Kumasaka T, Takahashi K, Seyama K. Pneumothorax caused by cystic and nodular lung metastases from a malignant uterine perivascular epithelioid cell tumor (PEComa). Respir Med Case Rep. 2017 Jun 27;22:77-82. doi: 10.1016/j.rmcr.2017.06.011. eCollection 2017.
131) Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Sakamoto N, Osada T, Watanabe S. Distinct histopathological characteristics in colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp and conventional tubular adenoma. Virchow Archiv, 2017 Sep 19. doi: 10.1007/s00428-017-2234-8.
132) Anzai T, Saito T, Tsuyama S, Toh M, Ikeda K, Ito S. A Case of Glomangiopericytoma at the Nasal Septum. Head Neck Pathol. 2017 Nov 22. doi: 10.1007/s12105-017-0870-6.
133) Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T. IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma. Oncotarget, 2018; 9:14428-14443. https://doi.org/10.18632/oncotarget.24467.
134) Naito T, Saito T, Higuchi T, Inomata A, Hayashi T, Shimada Y, Yamauchi-Ohguchi A, Kenmochi S, Kakinuma C, Yao T. Dedifferentiated liposarcoma of retroperitoneum spontaneously occurred in aged SD rat. Journal of Toxicologic Pathology, in press.
135) Hayashi T, Takamochi K, Yanai Y, Mitani K, Tomita H, Mogushi K, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T. Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p40. Hum Pathol. 2018 Feb 1. pii: S0046-8177(18)30037-6. doi: 10.1016/j.humpath.2018.01.023.
136) Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M, Kondo T, Taguchi T, Kawai A, Takagi T, Kaneko K, Yao T, Saito T. KCTD12 may be negatively regulated by Kit in gastrointestinal stromal tumors. Oncotarget. 2018 Jun 5;9(43):27016-27026. doi: 10.18632/oncotarget.25469. eCollection 2018 Jun 5
137) Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: Emphasis on the relationship with hepatoid adenocarcinoma. Human Pathol. 2018 Aug;78:79-88. doi: 10.1016/j.humpath.2018.04.022. Epub 2018 May 8.
138) Akaike K, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Okubo T, Hayashi Y, Takamoch K, Takahashi F, Kaneko K, Saito T. PPP2R1A regulated by PAX3/FOXO3 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. Oncotarget. 2018 May 18;9(38):25206-25215. doi: 10.18632/oncotarget.25392. eCollection 2018 May 18.
139) Hiromoto T, Murakami T, Akazawa Y, Sasahara N, Saito T, Sakamoto N, Mitomi H, Nagahara A, Yao T. Immunohistochemical and genetic characteristics of a colorectal mucin-rich variant of traditional serrated adenoma. Histopatholoy. 2018 May 5. doi: 10.1111/his.13643
140) Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H. Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens. Cancer Sci. 2019 Apr;110(4):1464-1479. doi: 10.1111/cas.13968. Epub 2019 Mar 5.
141) Akazawa Y, Hayashi T, Saito T, Niwa K, Kamiyama H, Sasahara N, Sakamoto K, Nagahara A, Yao T. Histological characteristics of eosinophilic myenteric ganglionitis, an under-recognised cause of chronic intestinal pseudo-obstruction. Virchows Arch. 2019 Jan 4. doi: 10.1007/s00428-018-02513-5.
142) Asahina M, Fukumura Y, Mamat O, Saito T, Hayashi T, Fujii H, Uekusa T, Suzuki K, Yao T. A case of combined small cell lung carcinoma with unique morphology: investigation of tumorigenesis. Pathol Int. 2018;68:618-623. doi: 10.1111/pin.12726.
143) Toda-Ishii M, Suehara Y, Kohsaka S, Hayashi T, Kazuno S, Tanabe Y, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T. Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma. Oncotarget. 2018;9:37509-37519. doi: 10.18632/oncotarget.26493.
144) Asahina M, Saito T, Hayashi T, Fukumura Y, Mitani K, Yao T. Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features. Histopathology. 2019;74:514-525. doi: 10.1111/his.13759.
145) Kurihara T, Suehara Y, Akaike K, Hayashi T, Okubo T, Kim Y, Takagi T, Kaneko K, Yao T, Saito T. Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report. Human Pathology Case reports. 2019, June, 100289
146) Kato S, Hayashi T, Suehara Y, Hananoue H, Yamanaka S, Ichikawa Y, Higurashi T, Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T, Yao T, Nakajima A, Syed A, Zehir A, Ladanyi M, Kato S. Multicenter experience with large panel next generation sequencing in patients with advanced solid cancers in Japan. Jap J Clin Oncol, 2018 Dec 12. doi: 10.1093/jjco/hyy173.
147) Murakami T, Yoichi Akazawa Y, Yatagai N, Takafumi Hiromoto T, Sasahara N, Saito T, Sakamoto N, Nagahara A, Yao T. Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study. Diagnostic Pathol. 2018 Nov 20;13(1):88. doi: 10.1186/s13000-018-0771-3.
148) Yatagai N, Saito T, Akazawa Y, Hayashi T, Yanai Y, Tsuyama S, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. Frequent loss of heterozygosity of SMAD4 locus and prognostic impacts of SMAD4 immunohistochemistry in gastric adenocarcinoma with enteroblastic differentiation. Human Pathol. 2019 Jun;88:18-26. doi: 10.1016/j.humpath.2019.03.005. Epub 2019 Apr 1.
149) Yatagai N, Saito T, Akazawa Y, Hayashi T, Yanai Y, Tsuyama S, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation. Virchows Archiv. 2019 Mar;474(3):315-324. doi: 10.1007/s00428-018-2508-9. Epub 2018 Dec 15.
150) Suehara Y, Mukaihara K, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Keisuke Akaike K, Kim Y, Kaneko K, Saito T. Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone. PROTEOMICS - Clinical Applications. 2019 Jul 9:e1800147. doi: 10.1002/prca.201800147
151) Saito T, Motoi T, Suehara Y, Takagi T, Okubo T, Kurihara T, Hayashi T, Yanai Y, Kudo T, Maruyama Y, Kaneko K, Yao T. Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review. Human Pathol Case Reports. 2019, June, 100288.
152) Tsuyama S, Saito T, Akazawa Y, Yanai Y, Akaike K, Hayashi T, Suehara Y, Takahashi F, Takamochi K, Hashimoto T, Kajiyama Y, Tsurumaru M, Fukunaga T, Takashi Yao T. Molecular and clinicopathological analyses in esophageal carcinosarcoma with special reference on the differentiation mechanism. Virchows Archiv. 2019 Oct;475(4):415-424. doi: 10.1007/s00428-019-02643-4. Epub 2019 Aug 23.
153) Murakami T, Yao T, Yatagai N, Yamashiro Y, Saito T, Sakamoto N, Nagahara A. Colorectal adenocarcinoma with enteroblastic differentiation: A clinicopathological study of five cases. Histopathology. 2020 Jan;76(2):325-332. doi: 10.1111/his.13973. Epub 2019 Oct 30.
154) Inoue S, Hirota Y, Ueno T, Fukui Y, Yoshida E, Hayashi T, Kojima S, Takeyama R, Hashimoto T, Kiyono T, Taguchi A, Tanaka T, Tanaka Y, Ikemura M, Sakata S, Takeuchi K, Muraoka A, Osuka S, Saito T, Oda K, Osuga Y, Terao Y, Kawazu M, Mano H. Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations. Nat Comm. Dec 19;10(1):5785. doi: 10.1038/s41467-019-13708-y.
155) Nakahodo J, Fukumura Y, Saito T, Mitomi H, Saiura A, MD, Fujisawa T, Ishii S, Isayama H, Kurahayashi I, Yao T. Radiological and Pathological Assessment of the 2017 Revised International Association of Pancreatology Consensus Guidelines for Intraductal Papillary Mucinous Neoplasm, With an Emphasis on the Gastric Pyloric Gland Type. Pancreas. 2020 Feb;49(2):216-223. doi: 10.1097/MPA.0000000000001487.
156) Hasegawa N, Kohsaka S, Nakamura I, Ueno T, Kojima S, Kawazu M, Akaike K, Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H. Detection of circulating sarcoma tumor cells using a microfluidic chip-type cell sorter. Sci Rep. 2019 Dec 27;9(1):20047. doi: 10.1038/s41598-019-56377-z
157) Hayashi T, Takamochi K, Kohsaka S, Kishikawa S, Suehara Y, Takahashi F, Suzuki K, Saito T, Mano H, Yao T. Spontaneous transformation form EGFR/PTEN co-mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis. Pathol Int. in press.
158) Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Sano K, Sasa K, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H. Assessment of predictive biomarkers of the response to pazopanib based on an integrative analysis of high-grade soft-tissue sarcomas: Analysis of a tumor sample from a responder and patients with other soft-tissue sarcomas. Clin Orthop Relat Res, in press.
159) Yanai Y, Hayashi T, Akazawa Y, Yatagai N, Tsuyama S, Yao T, Saito T. Clinicopathological and mutational differences between tumors with multiple metastases and single lung metastasis in colorectal cancer. Oncol letter, in press.
160) Yamashiro Y, Saito T, Hayashi T, Murakami T, Yanai Y, Tsuyama S, Suehara Y, PhD, Takamochi K, Yao T. Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation. Histopathology, in press. doi: 10.1111/his.14158.
161) Nakahodo J, Fukumura Y, Saito T, Hirabayashi K, Doi R, Hayashi T, Yao T. Upregulation of follistatin and low apoptotic activity in intraductal oncocytic papillary neoplasm of the pancreatobiliary system. Sci Repl, 2020, 10(1): 8179. doi: 10.1038/s41598-020-64920-6.
162) Asahina M, Hayashi T, Takamochi K, Saito T, Onagi H, Kishi M, Fukumura Y, Arakawa A, Suzuki K, Yao T. Identification of CTNNB1-PLAG1 gene rearrangement in a patient with pulmonary pleomorphic adenoma. Virchows Archiv, in press. Apr 19. doi: 10.1007/s00428-020-02810-y.
163) Sano K, Suehara Y, Okubo T, Sasa K, Kurihara T, Akaike K, Kubota D, Torigoe T, Hasegawa N, Ishii M, Kim Y, Takagi T, Kaneko K, Hayashi T, Saito T. Preoperative denosumab treatment with curettage maybe a risk factor for recurrence of giant cell tumor of bone. J Ortho Surg (Hong Kong). 2020 Jan-Apr;28(2):2309499020929786. doi: 10.1177/2309499020929786.
164) Tsuyama S, Kohsaka S, Hayashi T, Suehara Y, Hashimoto T, Kajiyama Y, Tsurumaru M, Ueno T, Mano H, Yao T, Saito T. Comprehensive analysis of the molecular and clinical characteristics of primary malignant melanoma of the esophagus. Histopathology, in press.
165) Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, Yao T. Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations. Human Pathol, in press.
166) Yanai Y, Saito T, Hayashi T, Akazawa Y, Yatagai N, Tsuyama S, Tomita S, Hirai S, Ogura K, Matsumoto T, Wada R, Yao T. Transition of low-grade appendiceal mucinous neoplasm to mucinous adenocarcinoma: A clinicopathological/comprehensive analysis. Virchows Arch. 2020 Aug 21. doi: 10.1007/s00428-020-02906-5. Online ahead of print.

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齋藤 剛（サイトウ ツヨシ）

齋藤剛（サイトウツヨシ）