2010年 研究業績
洋雑誌
- Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Nat Cell Bio. vol. 12, 213-223. - Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.
A novel type of E3 ligase for the Ufm1 conjugation system.
J Biol Chem. vol. 285, 5417-5427 - Komatsu M and Ichimura Y.
Physiological significance of selective degradation of p62 by autophagy.
FEBS Lett. vol. 584, 1374-1378. Review - Ichimura Y, Komatsu M.
Selective degradation of p62 by autophagy.
Semin Immunopathol. vol. 32, 431-436. Review - Komatsu M, Ichimura Y.
Selective autophagy regulates various cellular functions.
Genes Cells. vol. 15, 923-933. Review - Portillo JA, Okenka G, Reed E, Subauste A, Van Grol J, Gentil K, Komatsu M, Tanaka K, Landreth G, Levine B, Subauste CS.
The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.
PLoS One. - Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria.
Singh SB, Ornatowski W, Vergne I, Naylor J, Delgado M, Roberts E, Ponpuak M, Master S, Pilli M, White E, Komatsu M, Deretic V.
Nat Cell Biol. vol 12, 1154-1165. - Riley BE, Kaiser SE, Shaler TA, Ng AC, Hara T, Hipp MS, Lage K, Xavier RJ, Ryu KY, Taguchi K, Yamamoto M, Tanaka K, Mizushima N, Komatsu M, Kopito RR.
Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.
J Cell Biol. vol 191, 537-552. - Raben N, Schreiner C, Baum R, Takikita S, Xu S, Xie T, Myerowitz R, Komatsu M, Van der Meulen JH, Nagaraju K, Ralston E, Plotz PH.
Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease.
Autophagy. vol 6, 1078-1089. - Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu M, Simon AK.
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo.
Proc Natl Acad Sci U S A. vol 107, 832-837. - Wu JJ, Quijano C, Chen E, Liu H, Cao L, Fergusson MM, Rovira II, Gutkind S, Daniels MP, Komatsu M, Finkel T.
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy.
Aging (Albany NY). vol 1, 425-437. - Masiero E, Agatea L, Mammucari C, Blaauw B, Loro E, Komatsu M, Metzger D, Reggiani C, Schiaffino S, Sandri M.
Autophagy is required to maintain muscle mass.
Cell Metab. vol 10, 507-515. - Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S.
Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis.
Proc Natl Acad Sci U S A. vol 106, 19860-19865. - Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S.
Discovery of Atg5/Atg7-independent alternative macroautophagy.
Nature. vol 461, 654-658. - Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly MJ, Podolsky DK, Xavier RJ.
A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.
J Immunol. vol 182, 4917-4930. - Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M, Tanaka K, Cuervo AM, Czaja MJ.
Autophagy regulates lipid metabolism.
Nature. vol 458, 1131-1135. - Yue Z, Friedman L, Komatsu M, Tanaka K.
The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases.
Biochim Biophys Acta. vol 1793, 1496-1507. Review - Pua HH, Guo J, Komatsu M, He YW.
Autophagy is essential for mitochondrial clearance in mature T lymphocytes.
J Immunol. vol 182. 4046-4055. - Shibata M, Yoshimura K, Furuya N, Koike M, Ueno T, Komatsu M, Arai H, Tanaka K, Kominami E, Uchiyama Y.
The MAP1-LC3 conjugation system is involved in lipid droplet formation.
Biochem Biophys Res Commun. vol 382. 419-423. - Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T.
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Mol Cell. vol 33. 505-516. - Cadwell K, Patel KK, Komatsu M, Virgin HW 4th, Stappenbeck TS.
A common role for Atg16L1, Atg5 and Atg7 in small intestinal Paneth cells and Crohn disease.
Autophagy. vol 5. 250-252. - Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S.
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Nature. vol 456. 264-268. - Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H.
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.
Cell Metab. vol 8. 325-332. - Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS.
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia.
Cell Metab. 2008 Oct;8(4):318-24. - Ueno T, Sato W, Horie Y, Komatsu M, Tanida I, Yoshida M, Ohshima S, Mak TW, Watanabe S, Kominami E.
Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation.
Autophagy. vol 4. 692-700. - Oppenheim RW, Blomgren K, Ethell DW, Koike M, Komatsu M, Prevette D, Roth KA, Uchiyama Y, Vinsant S, Zhu C.
Developing postmitotic mammalian neurons in vivo lacking Apaf-1 undergo programmed cell death by a caspase-independent, nonapoptotic pathway involving autophagy.
J Neurosci. vol 28. 1490-1497. - Matsumoto N, Ezaki J, Komatsu M, Takahashi K, Mineki R, Taka H, Kikkawa M, Fujimura T, Takeda-Ezaki M, Ueno T, Tanaka K, Kominami E.
Comprehensive proteomics analysis of autophagy-deficient mouse liver.
Biochem Biophys Res Commun. vol 368. 643-649. - Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y.
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury.
Am J Pathol. vol 172. 454-469.
和雑誌
- 小松雅明：オートファジー選択的基質p62による抗酸化ストレス活性化機構，実験医学 Current Topics，vol. 28, 1737-1741.
- 一村義信，小松雅明：神経変性とオートファジー，実験医学，増刊，vol. 28, 140-145.
- 一村義信，小松雅明：オートファジー不全マウス研究からみた病態，Bio Clinica，vol. 25, 199-204.