2014年 研究業績

洋雑誌

1. Donohue E, Balgi AD, Komatsu M, Roberge M.
   Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin.

   PLoS One. 9:e114964.

2. Yoshihara N, Ueno T, Takagi A, Trejo JA, Haruna K, Suga Y, Komatsu M, Tanaka K, Ikeda S.
   The significant role of autophagy in the granular layer in normal skin differentiation and hair growth.

   Arch Dermatol Res. Epub ahead of print.

3. Lim YM, Lim H, Hur KY, Quan W, Lee HY, Cheon H, Ryu D, Koo SH, Kim HL, Kim J, Komatsu M, Lee MS.
   Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes.

   Nat Commun. 5:4934.

4. Yoo HM, Kang SH, Kim JY, Lee JE, Seong MW, Lee SW, Ka SH, Sou YS, Komatsu M, Tanaka K, Lee ST, Noh DY, Baek SH, Jeon YJ, Chung CH.
   Modification of ASC1 by UFM1 Is Crucial for ERα Transactivation and Breast Cancer Development.

   Mol Cell. 56:261-274.

5. Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K and Komatsu M.
   Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway.

   J Biol Chem. 289:24944-24955.

6. Kim J, Cheon H, Jeong YT, Quan W, Kim KH, Cho JM, Lim YM, Oh SH, Jin SM, Kim JH, Lee MK, Kim S, Komatsu M, Kang SW, Lee MS.
   Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.

   J Clin Invest. 124:3311-3324.

7. Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R.
   Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression.

   Cancer Cell. 26:106-120.

8. Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y.
   Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.

   Biochem Biophys Res Commun. 446:1190-1196.

9. Lystad AH, Ichimura Y, Takagi K, Yang Y, Pankiv S, Kanegae Y, Kageyama S, Suzuki M, Saito I, Mizushima T, Komatsu M, Simonsen A.
   Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

   EMBO Rep. 15:557-565.

10. Uemura T, Yamamoto M, Kametaka A, Sou YS, Yabashi A, Yamada A, Annoh H, Kametaka S, Komatsu M, Waguri S.
    A cluster of thin tubular structures mediates transformation of the ER to autophagic isolation membrane.

    Mol Cell Biol. 34:1695-1706.

11. Maruyama Y, Sou YS, Kageyama S, Takahashi T, Ueno T, Tanaka K, Komatsu M, Ichimura Y.
    LC3B is indispensable for selective autophagy of p62 but not basal autophagy.

    Biochem Biophys Res Commun. 446:309-315.

12. Ishimura R, Tanaka K, Komatsu M.
    Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.

    FEBS Lett. 588:822-828.

13. Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T.
    PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.

    Autophagy. 10:631-641.

14. Peng J, Zhang R, Cui Y, Liu H, Zhao X, Huang L, Hu M, Yuan X, Ma B, Ma X, Takashi U, Masaaki K, Liang X, Yu L.
    Atg5 regulates late endosome and lysosome biogenesis.

    Sci China Life Sci. 57:59-68.

和雑誌

1. 蔭山俊、小松雅明「オートファジーと疾患」 領域融合レビュー, 3, e006, 2014
2. 一村義信 「選択的オートファジーと疾患」 Thrombosis Medicine 4, 215-220, 2014
3. 一村義信 「オートファジーとがん治療」 腫瘍内科13, 810-816, 2014

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