2017年 研究業績

洋雑誌

1. Yanagisawa H, Ishii T, Endo K, Kawakami E, Nagao K, Miyashita T, Akiyama K, Watabe K, Komatsu M, Yamamoto D, Eto Y.
   L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease.

   Sci Rep. 2017 Nov 21;7(1):15944

2. Yasuda D, Yuasa A, Obata R, Nakajima M, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
   Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.

   Bioorg Med Chem Lett. 2017 Nov 15;27(22):5006-5009

3. Kuma A, Komatsu M, Mizushima N.
   Autophagy-monitoring and autophagy-deficient mice.

   Autophagy. 2017 Oct 3;13(10):1619-1628

4. Kim TS, Shin YH, Lee HM, Kim JK, Choe JH, Jang JC, Um S, Jin HS, Komatsu M, Cha GH, Chae HJ, Oh DC, Jo EK.
   Ohmyungsamycins promote antimicrobial responses through autophagy activation via AMP-activated protein kinase pathway.

   Sci Rep. 2017 Jun 13;7(1):3431

5. Yamaguchi J, Suzuki C, Nanao T, Kakuta S, Ozawa K, Tanida I, Saitoh T, Sunabori T, Komatsu M, Tanaka K, Aoki S, Sakimura K, Uchiyama Y.
   Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis.

   Autophagy. 2017 May 17:1-14

6. Koike M, Shibata M, Sunabori T, Yamaguchi J, Sakimura K, Komatsu M, Tanaka K, Uchiyama Y.
   Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7.

   Am J Pathol. 2017 Jul;187(7):1586-1600

7. van Wijk SJL, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, Grumati P, Kaulich M, Sou YS, Komatsu M, Greten FR, Fulda S, Heilemann M, Dikic I.
   Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.

   Nat Microbiol. 2017 May 8;2:17066

8. Peng H, Yang J, Li G, You Q, Han W, Li T, Gao D, Xie X, Lee BH, Du J, Hou J, Zhang T, Rao H, Huang Y, Li Q, Zeng R, Hui L, Wang H, Xia Q, Zhang X, He Y, Komatsu M, Dikic I, Finley D, Hu R.
   Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

   Cell Res. 2017 May;27(5):657-674

9. Ueno T, Komatsu M.
   Autophagy in the liver: functions in health and disease.

   Nat Rev Gastroenterol Hepatol. 2017 Mar;14(3):170-184

10. Ishimura R, Obata M, Kageyama S, Daniel J, Tanaka K, Komatsu M.
    A novel approach to assess the ubiquitin-fold modifier 1-system in cells.

    FEBS Lett. 2017 Jan;591(1):196-204

和雑誌

1. 坂井俊介、小松雅明 「オートファジーと疾患」 臨床病理 65:653-660, 2017
2. 蔭山俊、小松雅明 「オートファジーとKeap1-Nrf2システム」 最新医学 72(2):70-77, 2017
3. 小松雅明 「オートファジーとがん代謝」 実験医学 35:110-117, 2017

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