2021年 研究業績

洋雑誌

1. Sango J, Kakihana T, Takahashi M, Katsuragi Y, Anisimov S, Komatsu M, Fujii M.
   USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity

   J Biol Chem. 2021 Nov 24;298(1):101448. doi: 10.1016/j.jbc.2021.101448.

2. Faruk MO, Ichimura Y, Kageyama S, Komatsu-Hirota S, El-Gowily AH, Sou YS, Koike M, Noda NN, Komatsu M.
   Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show reduced inner fluidity

   J Biol Chem. 2021 Nov 11:101405. doi: 10.1016/j.jbc.2021.101405.

3. Nagata T, Minami K, Yamamoto M, Hiraki T, Idogawa M, Fujimoto K, Kageyama S, Tabata K, Kawahara K, Ueda K, Ikeda R, Kato Y, Komatsu M, Tanimoto A, Furukawa T, Sato M.
   BHLHE41/DEC2 Expression Induces Autophagic Cell Death in Lung Cancer Cells and Is Associated with Favorable Prognosis for Patients with Lung Adenocarcinoma

   Int J Mol Sci. 2021 Oct 26;22(21):11509. doi: 10.3390/ijms222111509.

4. Sakai SS, Hasegawa A, Ishimura R, Tamura N, Kageyama S, Komatsu-Hirota S, Abe M, Ling Y, Okuda S, Funayama M, Kikkawa M, Miura Y, Sakimura K, Narita I, Waguri S, Shimizu R, Komatsu M.
   Loss of Atg2b and Gskip impairs the maintenance of the hematopoietic stem cell pool size

   Mol Cell Biol . 2021 Nov 8;MCB0002421. doi: 10.1128/MCB.00024-21.

5. Nishida M, Yamashita N, Ogawa T, Koseki K, Warabi E, Ohue T, Komatsu M, Matsushita H, Kakimi K, Kawakami E, Shiroguchi K, Udono H.
   Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes

   J Immunother Cancer. 2021 Sep;9(9):e002954. doi: 10.1136/jitc-2021-002954.

6. Faruk MO, Ichimura Y, Komatsu M.
   Selective autophagy

   Cancer Sci. 2021 Aug 18. doi: 10.1111/cas.15112.

7. Maruyama T, Alam JM, Fukuda T, Kageyama S, Kirisako H, Ishii Y, Shimada I, Ohsumi Y, Komatsu M, Kanki T, Nakatogawa H, Noda NN.
   Membrane perturbation by lipidated Atg8 underlies autophagosome biogenesis

   Nat Struct Mol Biol. 2021 Jul;28(7):583-593. doi: 10.1038/s41594-021-00614-5. Epub 2021 Jul 8.

8. Eskelinen EL, Kageyama S, Komatsu M.
   p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control

   Mol Cell Oncol. 2021 Mar 9;8(2):1890990. doi: 10.1080/23723556.2021.1890990.

9. Briere LC, Walker MA, High FA, Rogers CA, Callahan C, Cooper C, Ishimura R, Ichimura Y, Caruso PA, Sharma N, Brokamp E, Koziura ME, Mohammad SS, Dale RC, Riley LG, Network UD, Phillips JA, Komatsu M, Sweetser DA.
   A Description of Novel Variants and Review of Phenotypic Spectrum in UBA5-related Early Epileptic Encephalopathy

   Cold Spring Harb Mol Case Stud. 2021 Apr 2:mcs.a005827. doi: 10.1101/mcs.a005827.

10. Nomura N, Ito C, Ooshio T, Tadokoro Y, Kohno S, Ueno M, Kobayashi M, Kasahara A, Takase Y, Kurayoshi K, Si S, Takahashi C, Komatsu M, Yanagawa T, Hirao A.
    Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner

    Sci Rep. 2021 Jan 18;11(1):1666. doi: 10.1038/s41598-021-81076-z.

11. Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M.
    p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response

    Nat Commun. 2021 Jan 4;12(1):16. doi: 10.1038/s41467-020-20185-1.

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