順天堂大学医学部生理学第二講座

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2022年 研究業績

洋雑誌

  1. Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M.
    The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3

    Nat Commun. 2022 Dec 21;13(1):7857. doi: 10.1038/s41467-022-35501-0.
  2. Ikutama R, Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
    Cathelicidin LL-37 Activates Human Keratinocyte Autophagy through the P2X₇, Mechanistic Target of Rapamycin, and MAPK Pathways

    J Invest Dermatol. 2022 Nov 28:S0022-202X(22)02823-8. doi: 10.1016/j.jid.2022.10.020.
  3. Morishita H, Komatsu M.
    Role of autophagy in liver diseases

    Current Opinion in Physiology. Volume 30, December 2022, 100594
  4. Morishita H.
    Role of autophagy in the eye: from physiology to disease

    Current Opinion in Physiology. Volume 30, December 2022, 100592
  5. Komatsu M.
    p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation

    IUBMB Life. 2022 Nov 4. doi: 10.1002/iub.2689.
  6. Park SW, Jeon P, Yamasaki A, Lee HE, Choi H, Mun JY, Jun YW, Park JH, Lee SH, Lee SK, Lee YK, Song HK, Lazarou M, Cho DH, Komatsu M, Noda NN, Jang DJ, Lee JA.
    Development of new tools to study membrane-anchored mammalian Atg8 proteins

    Autophagy. 2022 Oct 17:1-20. doi: 10.1080/15548627.2022.2132040.
  7. Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F.
    Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway

    J Clin Invest. 2022 Jul 14:e156501. doi: 10.1172/JCI156501.
  8. Ono M, Komatsu M, Ji B, Takado Y, Shimojo M, Minamihisamatsu T, Warabi E, Yanagawa T, Matsumoto G, Aoki I, Kanaan NM, Suhara T, Sahara N, Higuchi M.
    Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy

    Aging Cell. 2022 Jun 5:e13615. doi: 10.1111/acel.13615.
  9. Ding WX, Ni HM, Waguri S, Komatsu M.
    Lack of Hepatic Autophagy Promotes Severity of Liver Injury but Not Steatosis

    J Hepatol. 2022 May 25:S0168-8278(22)00330-0. doi: 10.1016/j.jhep.2022.05.015.
  10. Suzuki A, Iwaya C, Ogata K, Yoshioka H, Shim J, Tanida I, Komatsu M, Tada N, Iwata J.
    Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren's syndrome-like exocrinopathy

    Cell Mol Life Sci. 2022 May 20;79(6):307. doi: 10.1007/s00018-022-04334-x.
  11. Ichimura Y, Komatsu M.
    Considering the mechanism by which droplets of ALS-FTD-associated SQSTM1/p62 mutants cause pathology

    Autophagy Reports 2022, Vol. 1, No. 1, 9–13
  12. Sakai M, Yu Z, Hirayama R, Nakasato M, Kikuchi Y, Ono C, Komatsu H, Nakanishi M, Yoshii H, Stellwagen D, Furuyashiki T, Komatsu M, Tomita H.
    Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance

    Neural Plast. 2022 Feb 16;2022:7503553. doi: 10.1155/2022/7503553. eCollection 2022.
  13. Takahashi M, Kitaura H, Kakita A, Kakihana T, Katsuragi Y, Onodera O, Iwakura Y, Nawa H, Komatsu M, Fujii M.
    USP10 inhibits aberrant cytoplasmic aggregation of TDP-43 by promoting stress granule clearance

    Mol Cell Biol. 2022 Jan 10:MCB0039321. doi: 10.1128/MCB.00393-21.

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