Focus
The Heissig laboratory is recognized internationally for discovering protease functions' molecular and cellular basis and their role in normal and diseased tissues.
Understanding the target molecules of proteases provides critical insights into fundamental biological cellular functions. The Heissig lab seeks a comprehensive understanding of the regulatory mechanisms by which proteases control cell behavior in normal and pathological conditions, namely inflammation, cancer growth, tissue regeneration (blood vessel formation), and stem cell fate, including proliferation, differentiation, and migration.
Cellular Microenvironment
Work from the Heissig group has provided compelling evidence that changes in the protease expression pattern locally – we coined the word proteolytic niche – change the cellular and functioning environment of the tissues. Proteases enhance angiogenesis and the influx of inflammatory cells, which are critical drivers of tissue regeneration and cancer progression.
Stem cells
We have pointed out the importance of proteases in regulating the hematopoietic and cancer stem cell fate and the establishment of its supportive niche. We have shown that matrix metalloproteinases (MMPs) and factors of the fibrinolytic and coagulation system control stem cell fate (differentiation versus self-renewal) and migration.
Current Research
Currently, the Heissig laboratory is focused on elucidating the role of fibrinolytic factors, their complexes, fragments, and receptors in the inflammatory process, such as during COVID-19 infection.
Current Projects
Sodium-glucose cotransporters in cancer
Fibrinolytic factor fragments and their receptors in angiogenesis
Characteristics of the Lab
Our goal is to provide an international platform for vibrant scientific exchange and to conduct cutting-edge, highly competitive research with strong potential for clinical translation. The laboratory brings together scientists from basic research disciplines and physician-scientists who combine their expertise to address critical challenges in medicine. English is the primary language for daily communication and scientific discussion, creating an environment that attracts international researchers and fosters collaboration. The laboratory maintains active research collaborations with institutions across Europe, the United States, and Asia.
A cornerstone of the laboratory is its long-standing collaboration with Dr. Koichi Hattori of the Center for Genomic and Regenerative Medicine, Juntendo University Graduate School of Medicine（Researchmap｜Juntendo University Profile｜Google Scholar）. Associate Professor Beate Heissig and Dr. Hattori have worked together for more than 25 years to establish and develop the laboratory into an internationally recognized research and training environment. Dr. Hattori is an indispensable collaborator of the laboratory. His scientific expertise and leadership, mentorship of students and early-career researchers, and contributions to grant acquisition, research programme development, and scientific publications are integral to the laboratory’s continued operation and development.
LOCATION
7th building, 5th floor, Room 5N
