RESEARCH

The Heissig laboratory is recognized internationally for discovering protease functions' molecular and cellular basis and their role in normal and diseased tissues.
Understanding the target molecules of proteases provides critical insights into fundamental biological cellular functions. The Heissig lab seeks a comprehensive understanding of the regulatory mechanisms by which proteases control cell behavior in normal and pathological conditions, namely inflammation, cancer growth, tissue regeneration (blood vessel formation), and stem cell fate, including proliferation, differentiation, and migration.

Cellular Microenvironment

Work from the Heissig group has provided compelling evidence that changes in the protease expression pattern locally – we coined the word proteolytic niche – change the cellular and functioning environment of the tissues. Proteases enhance angiogenesis and the influx of inflammatory cells, which are critical drivers of tissue regeneration and cancer progression.

Stem cells

We have pointed out the importance of proteases in regulating the hematopoietic and cancer stem cell fate and the establishment of its supportive niche. We have shown that matrix metalloproteinases (MMPs) and factors of the fibrinolytic and coagulation system control stem cell fate (differentiation versus self-renewal) and migration.

Current Research

Currently, the Heissig laboratory is focused on elucidating the role of fibrinolytic factors, their complexes, fragments, and receptors in the inflammatory process, such as during COVID-19 infection.