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Atopy Research Center
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 �y2004�z
  1. Nishiyama C, Akizawa Y, Nishiyama M, Tokura T, Kawada H, Mitsuishi K, Hasegawa M, Ito T, Nakano N, Okamoto A, Takagi A, Yagita H, Okumura K, Ogawa H: Polymorphisms in the Fc epsilon RI beta promoter region affecting transcription activity: a possible promoter-dependent mechanism for association between Fc epsilon RI beta and atopy. J Immunol, 173:6458-64, 2004
  2. Niyonsaba F, Ogawa H, Nagaoka I: Human beta-defensin-2 functions as a chemotactic agent for tumour necrosis factor-alpha-treated human neutrophils. Immunology, 111:273-81, 2004
  3. Sakata Y, Arima K, Takeshita K, Takai T, Aoki S, Ogawa H, Sugihara H, Fujimoto K, Izuhara K: Characterization of novel squamous cell carcinoma antigen-related molecules in mice. Biochem Biophys Res Commun, 324:1340-1345, 2004
  4. Ushio H, Nakao A, Supajatura V, Miyake K, Okumura K, Ogawa H: MD-2 is required for the full responsiveness of mast cells to LPS but not to PGN. Biochem Biophys Res Commun, 323:491-498, 2004
  5. Xu H, Okamoto A, Ichikawa J, Ando T, Tasaka K, Masuyama K, Ogawa H, Yagita H, Okumura K, Nakao A: TWEAK/Fn14 interaction stimulates human bronchial epithelial cells to produce IL-8 and GM-CSF. Biochem Biophys Res Commun, 318:422-427, 2004
  6. Nishiyama C, Nishiyama M, Ito T, Masaki S, Maeda K, Masuoka N, Yamane H, Kitamura T, Ogawa H, Okumura K: Overproduction of PU.1 in mast cell progenitors: its effect on monocyte- and mast cell-specific gene expression. Biochem Biophys Res Commun, 313:516-521, 2004
  7. Sakata Y, Arima K, Takai T, Sakurai W, Masumoto K, Yuyama N, Suminami Y, Kishi F, Yamashita T, Kato T, Ogawa H, Fujimoto K, Matsuo Y, Sugita Y, Izuhara K: The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. J Biol Chem, 279:5081-7, 2004
  8. Nishiyama C, Masuoka N, Nishiyama M, Ito T, Yamane H, Okumura K, Ogawa H: Evidence against requirement of Ser41 and Ser45 for function of PU.1: Molecular cloning of rat PU.1. FEBS Lett, 572:57-64, 2004
  9. Nishiyama C, Nishiyama M, Ito T, Masaki S, Masuoka N, Yamane H, Kitamura T, Ogawa H, Okumura K: Functional analysis of PU.1 domains in monocyte-specific gene regulation. FEBS Lett, 561:63-68, 2004
  10. Prapars M, Nakao A, Nakano H, Jin L, Ogawa H: Expression of phosphorylated Smad2 in normal human epidermis. J Dermatol Sci, 34:54-55, 2004
  11. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Ogawa H: Exogenous Smad3 accelerates wound healing in a rabbit dermal ulcer model. J Invest Dermatol, 123:229-236, 2004
  12. Jin L, Nakao A, Nakayama M, Yamaguchi N, Kojima Y, Nakano N, Tsuboi R, Okumura K, Yagita H, Ogawa H: Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. J Invest Dermatol, 122:1175-1179, 2004
  13. Inazaki K, Kanamaru Y, Kojima Y, Sueyoshi N, Okumura K, Kaneko K, Yamashiro Y, Ogawa H, Nakao A: Smad3 deficiency attenuates renal fibrosis, inflammation, and apoptosis after unilateral ureteral obstruction. Kidney Int, 66:597-604, 2004
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 �y2003�z
  1. Miyahira Y, Akiba H, Katae M, Kubota K, Kobayashi S, Takeuchi T, García-Sastre A, Fukuchi Y, Okumura K, Yagita H, Aoki T: A potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-pecific CD8+ T cell response by DNA and viral vector vaccination. J Immunol, 171:6344-6348, 2003
  2. Takahashi K, Nishiyama C, Hasegawa M, Akizawa Y, Ra C: Regulation of the human high affinity IgE receptor beta-chain gene expression via an intronic element. J Immunol, 171:2478-84, 2003
  3. Hasegawa M, Nishiyama C, Nishiyama M, Akizawa Y, Mitsuishi K, Ito T, Kawada H, Furukawa S, Ra C, Okumura K, Ogawa H: A novel-66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J Immunol, 171:1927-33, 2003
  4. Hasegawa M, Nishiyama C, Nishiyama M, Akizawa Y, Takahashi K, Ito T, Furukawa S, Ra C, Okumura K, Ogawa H: Regulation of the human Fc epsilon RI alpha-chain distal promoter. J Immunol, 170:3732-8, 2003
  5. Maeda K, Nishiyama C, Tokura T, Akizawa Y, Nishiyama M, Ogawa H, Okumura K, Ra C: Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol, 170:334-40, 2003
  6. Akizawa Y, Nishiyama C, Hasegawa M, Maeda K, Nakahata T, Okumura K, Ra C, Ogawa H: Regulation of the human Fc epsilon RI beta-chain gene expression by Oct-1. Int Immunol, 15:549-56, 2003
  7. Miyahira Y, Akiba H, Ogawa S, Ishi T, Watanabe S, Kobayashi S, Takeuchi T, Aoki T, Tezuka K, Abe R, Okumura K, Yagita H, Watanabe N: Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett, 89:193-199, 2003
  8. Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T: Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun, 71:3131-3137, 2003
  9. Miyahira Y, Katae M, Takeda K, Yagita H, Okumura K, Kobayashi S, Takeuchi T, Kamiyama T, Fukuchi Y, Aoki T: Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun, 71:1234-1241, 2003
  10. Nishiyama C, Yokota T, Nishiyama M, Ra C, Okumura K, Ogawa H: Molecular cloning of rat transcription factor YY1. Biosci Biotechnol Biochem, 67:654-8, 2003
  11. Higashi K, Inagaki Y, Fujimori K, Nakao A, Kaneko H, Nakatsuka I: IFN-gamma interferes with transforming growth factor-beta signaling through direct interaction of YB-1 with Smad3. J Biol Chem, 278:43470-43479, 2003
  12. Ogihara T, Watada H, Kanno R, Ikeda F, Nomiyama T, Tanaka Y, Nakao A, German MS, Kojima I, Kawamori R: p38 mitogen-activated protein kinase is involved in activin A- and HGF-mediated expression of pro-endocrine gene neurogenin3 in AR42J-B13 cells. J Biol Chem, 278:21693-21700, 2003
  13. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Tsuboi R, Ogawa H: Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol, 149:464-70, 2003
  14. Hashimoto Y, Suga Y, Chikenji T, Matsuba S, Mizoguchi M, Kakuta M, Ogawa H: Immunohistological characterization of a Japanese case of pityriasis rotunda. Br J Dermatol, 149:196-8, 2003
  15. Warnnissorn P, Nakao A, Suto H, Ushio H, Yamaguchi N, Yagita H, Okumura K, Ogawa H: Tumour necrosis factor-related apoptosis-inducing ligand expression in atopic dermatitis. Br J Dermatol, 148: 829-831, 2003
  16. Aronchik I, Behne MJ, Leypoldt L, Crumrine D, Epstein E, Ikeda S, Mizoguchi M, Bench G, Pozzan T, Mauro: Actin reorganization is abnormal and cellular ATP is decreased in Hailey-Hailey keratinocytes. J Invest Dermatol, 121:681-7, 2003
  17. Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H: Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci, 33:31-40, 2003
  18. Hasegawa T, Nakao A, Sumiyoshi K, Tsuboi R, Ogawa H: IFN-gamma fails to antagonize fibrotic effect of TGF-beta on keloid-derived dermal fibroblasts. J Dermatol Sci, 32:19-24, 2003
  19. Sumiyoshi K, Nakao A, Setoguchi Y, Tsuboi R, Okumura K, Ogawa H: TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells. J Dermatol Sci, 31:53-8, 2003
  20. Kanamaru Y, Nakao A, Tanaka Y, Inagaki Y, Ushio H, Shirato I, Horikoshi S, Okumura K, Ogawa H, Tomino Y: Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol, 95:e36-42, 2003
  21. Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, De Crombrugghe B, Watanabe T, Okazaki I: Interferon-alpha down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology, 38:890-899, 2003
  22. Funaki T, Nakao A, Ebihara N, Setoguchi Y, Fukuchi Y, Okumura K, Ra C, Ogawa H, Kanai A: Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro. Cornea, 22:153-9, 2003
  23. Roeber D, Achari A, Takai T, Okumura Y, Scott DL: Crystallization and preliminary X-ray analysis of Der f 2, a potent allergen derived from the house dust mite (Dermatophagoides farinae). Acta Cryst, D59:1046-1048, 2003
  24. Niyonsaba F, Hirata M, Ogawa H, Nagaoka I: Epithelial cell-derived antibacterial peptides human beta-defensins and cathelicidin: multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy, 2:224-31, 2003
  25. Sanmano B, Hiruma M, Mizoguchi M, Ogawa H: Abbreviated oral itraconazole therapy for tinea corporis and tinea cruris. Mycoses, 46:316-21, 2003
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 �y2002�z
  1. Nishiyama C, Hasegawa M, Nishiyama M, Takahashi K, Akizawa Y, Yokota T, Okumura K, Ogawa H, Ra C: Regulation of human Fc epsilon RI alpha-chain gene expression by multiple transcription factors. J Immunol, 168:4546-52, 2002
  2. Supajatura V, Ushio H, Wada A, Yahiro K, Okumura K, Ogawa H, Hirayama T, Ra C: Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori, directly activates mast cells for migration and production of proinflammatory cytokines. J Immunol, 168: 2603-2607, 2002
  3. Nakayama M, Ishidoh K, Kayagaki N, Kojima Y, Yamaguchi N, Nakano H, Kominami E, Okumura K, Yagita H: Multiple pathways of TWEAK-induced cell death. J Immunol, 168:734, 2002
  4. Niyonsaba F, Iwabuchi K, Matsuda H, Ogawa H, Nagaoka I: Epithelial cell-derived human beta-defensin-2 acts as chemotaxin for mast cells through pertussis toxin-sensitive and phospholipase C-dependent pathway. Int Immunol, 14:421-6, 2002
  5. Suzuki R, Nakao A, Kanamaru Y, Okumura K, Ogawa H, Ra C: Localization of intestinal intraepithelial T lymphocytes involves regulation of alphaEbeta7 expression by transforming growth factor-beta. Int Immunol, 14:339-345, 2002
  6. Futagawa T, Akiba H, Kodama T, Takeda K, Hosoda Y, Yagita H, Okumura K: Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol, 14:275-286, 2002
  7. Nakao A, Sagara H, Setoguchi Y, Okada T, Okumura K, Ogawa H, Fukuda T: Expression of Smad7 in bronchial epithelial cells is inversely correlated to basement membrane thickness and airway hyperresponsiveness in patients with asthma. J Allergy Clin Immunol, 110:873-878, 2002
  8. Sagara H, Okada T, Okumura K, Ogawa H, Ra C, Fukuda T, Nakao A: Activation of TGF-beta/Smad2 signaling is associated with airway remodeling in asthma. J Allergy Clin Immunol, 110:249-254, 2002
  9. Niyonsaba F, Iwabuchi K, Someya A, Hirata M, Matsuda H, Ogawa H, Nagaoka I: A cathelicidin family of human antibacterial peptide LL-37 induces mast cells chemotaxis. Immunology, 106:20-6, 2002
  10. Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Tanaka S, Heumann D: Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol, 9:972-82, 2002
  11. Takahashi K, Nishiyama C, Ra C: Transcriptional regulation of the human high affinity IgE receptor alpha-chain gene. Mol Immunol, 38:1193-9, 2002
  12. Katae M, Miyahira Y, Takeda K, Matsuda H, Yagita H, Okumura K, Takeuchi T, Kamiyama T, Ohwada A, Fukuchi Y, Aoki T: Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy. Infect Immun, 70:4833-4840, 2002
  13. Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H: Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest, 109:1351-1359, 2002
  14. Sumiyoshi K, Nakao A, Ushio H, Mitsuishi K, Okumura K, Tsuboi R, Ra C, Ogawa H: Transforming growth factor-beta1 suppresses atopic dermatitis-like skin lesions in NC/Nga mice. Clin Exp Allergy, 32:309-314, 2002
  15. Harada N, Nakayama M, Nakano H, Fukuchi Y, Yagita H, Okumura K: Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vin endothelial cells. Biochem Biophys Res Commun, 299:488, 2002
  16. Nishiyama C, Takahashi K, Ohtake Y, Yokota T, Okumura K, Ogawa H, Ra C: Analysis of transactivation region of Elf-1 by using a yeast one-hybrid system. Biosci Biotechnol Biochem, 66:875-7, 2002
  17. Nakao A, Okumura K, Ogawa H: Smad7: a new key player in TGF-beta-associated disease. Trends Mol Med (Formerly; Mol. Med. Today), 8:361-363, 2002
  18. Inagaki Y, Nemoto T, Nakao A: Transcriptional regulation of type I collagen gene expression by transforming growth factor-beta/Smad signaling and its antagonistic factors. Connective Tissue, 34:139-146, 2002
  19. Takai T, Mineki R, Nakazawa T, Takaoka M, Yasueda H, Murayama K, Okumura K, Ogawa H: Maturation of recombinant mite allergen Der p 1 and Der f 1, and its implication in the blockade of proteolytic activity. FEBS Lett, 531:265-272, 2002
  20. Okuda M, Yoshiike T, Ogawa H: Detergent-induced epidermal barrier dysfunction and its prevention. J Dermatol Sci, 30:173-9, 2002
  21. Okado T, Terada Y, Tanaka H, Inoshita S, Nakao A, Sasaki S: Smad7 mediates transforming growth factor-beta-induced apoptosis in mesangial cells. Kidney Int, 62:1178-1186, 2002
  22. Terada Y, Hanada S, Nakao A, Kuwahara M, Sasaki S, Marumo F: Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int, 61 (sym.1):S94-S98, 2002
  23. Kanamaru Y, Nakao A, Shirato I, Okumura K, Ogawa H, Tomino Y, Ra C: Chronic graft-versus-host autoimmune disease in Fc receptor gamma chain-deficient mice results in lipoprotein glomerulopathy. J Am Soc Nephrol, 13:1527-1533, 2002
  24. Kanamaru Y, Nakao A, Ra C, Okumura K, Muso E, Ogawa H, Kobayashi I, Horikoshi S, Tomino Y: Role of transforming growth factor-beta/Smad signaling pathway in enhanced production of glomerular extracellular matrix in IgA nephropathy of high-serum IgA ddY mice. Nephrology, 7:S151-155, 2002
  25. Ebihara N, Okumura K, Nakayasu K, Kanai A, Ra C. High level of Fc epsioln RI-bindable IgE in the tear fluid and increase IgE-saturated cells in the giant papillae of vernal keratoconjunctivitis patients. Jpn J Ophthalmol, 46:357-363, 2002
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 �y2001�z
  1. Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D: Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells. J Immunol, 167:3329-38, 2001
  2. Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H: Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol, 167: 2250-2256, 2001
  3. Okazaki T, Nakao A, Nakano H, Takeda K, Shimozato O, Takahashi F, Takahashi K, Yagita H, Okumura K: Impairment of bleomycin-induced lung fibrosis in CD28-deficient mice. J Immunol, 167:1977-1981, 2001
  4. Kanamaru Y, Nakao A, Mamura M, Suzuki Y, Shirato I, Okumura K, Tomino Y, Ra C: Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis. J Immunol, 166:2818-2823, 2001
  5. Nohara C, Akiba H, Nakajima A, Inoue A, C.S. Koh, Ohshima H, Yagita H, Mizuno Y, Okumura K: Amelioration of experimental autoimmune encephalomyelitis with anti- OX40 ligand monoclonal antibody: a critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J Immunol, 166:2108-2115, 2001
  6. Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I: Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells. Eur J Immunol, 31:1066-75, 2001
  7. Takahashi K, Nishiyama C, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T: A complex composed of USF1 and USF2 activates the human Fc epsilon RI alpha chain expression via a CAGCTG element in the first intron. Eur J Immunol, 31:590-9, 2001
  8. Hira K, Mitsuishi K, Kawamoto K, Suto H, Nakao A, Ra C, Ogawa H: Establishment and characterization of a murine mast cell line derived from NC/Nga mice. Int Arch Allergy Clin Immunol 125 (S1):67-70, 2001
  9. Nakao A: The TGF-beta1 paradox in asthma. Trends Immunol (Formerly; Immunol. Today), 22:300, 2001
  10. Nakao A: Is transforming growth factor-beta1 the key to suppression of human asthma? Trends Immunol (Formerly; Immunol. Today), 22:115-118, 2001
  11. Uchida T, Nakao A, Nakano N, Kuramasu A, Saito H, Okumura K, Ra C, Ogawa H: Identification of NASH1, a novel protein containing a nuclear localization signal, a sterile a motif, and a SH3 domain preferentially expressed in mast cells. Biochem Biophys Res Commun, 288:137-141, 2001
  12. Nishiyama C, Hasegawa M, Nishiyama M, Takahashi K, Yokota T, Okumura K, Ra C: Cloning of full length genomic DNA encoding human Fc epsilon RI alpha-chain and its transcriptional regulation. Biochem Biophys Res Commun, 284:1056-64, 2001
  13. Takai T, Takahashi K, Akagawa-Chihara M, Fukada M, Yuuki T, Shibuya I, Okumura K, Ra C, Yokota T, Okumura Y: Production of humanized antibody against human high-affinity IgE receptor in a serum free culture of CHO cells and purification of the Fab fragments. Biosci Biotechnol Biochem, 65:1082-1089, 2001
  14. Takai T, Okumura K, Ra C: Direct expression of the extracellular portion of human Fc epsilon RI alpha chain in Escherichia coli. Biosci Biotechnol Biochem, 65:79-85, 2001
  15. Takahashi K, Nishiyama C, Okumura K, Ra C, Ohtake Y, Yokota T: Molecular cloning of rat USF2 cDNA and characterization of splicing variants. Biosci Biotechnol Biochem, 65:56-62, 2001
  16. Inagaki Y, Nemoto T, Nakao A, ten Dijke P, Kobayashi K, Takehara K, Greenwel P: Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha2(I) collagen gene transcription. J Biol Chem, 276:16573-16579, 2001
  17. Takai T, Okumura K, Ra C, Yokota T, Okumura Y: Expression of humanized Fab fragments that recognize the IgE-binding domain of human Fc epsilon RI alpha chain. J Biochem, 129:5-12, 2001
  18. Inagaki Y, Mamura M, Kanamaru Y, Greenwell P, Takehara K, ten Dijke P, Nakao A: Constitutive phosphorylation and nuclear localization of Smad3 correlate to increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol, 187:117-123, 2001
  19. Palungwachira P, Chirachanakul P, Palungwachira P, Chalugun P, Nakao A, Takamori K, Ogawa H: Cutaneous findings in HIV-1-positive patients in Thailand. The Journal of Dermatology, 10:584-585, 2001
  20. Aioi A, Tonogaito H, Suto H, Hamada K, Ra C, Ogawa H, Maibach H, Matsuda H: Defective skin barrier function in NC/Nga mice. Br J Dermatol, 144: 12-18, 2001
  21. Nakajima T, Matsumoto K, Suto H, Tanaka K, Ebisawa M, Tomita H, Yuki K, Katsunuma T, Akasawa A, Hashida R, Sugita Y, Ogawa H, Ra C, Saito H: Gene expression screening of human mast cells and eosinophils using high-density oligonucleotide probearrays : Abundant expression of major basic protein in mast cells. Blood, 15;98:1127-34, 2001
  22. Iida M, Matsumoto K, Tomita H, Nakajima T, Akasawa A, Yuyama N, Yoshida N.L, Matsui K, Nakada A, Sugita Y, Shimizu Y, Wakahara Y, Nakao T, Fujii Y, Ra C, Saito H: Selective down-regulation of high-affinity IgE receptor (Fc epsilon RI)alpha-chain messenger RNA among transcriptome in code blood-derived versus adult peripheral blood-derived cultured human mast cells. Blood, 97:1016-1022, 2001
  23. Gounne A.S, Lamkhioued B.L, Koussih L, Ra C, Renzi P.M, Hamid Q: Human neutrophils express the high-affinity receptor for immunoglobulin E(Fc epsilon RI):role in asthma. FASEB J, 15:940-949, 2001
  24. Tsuge T, Shimokawa T, Horikoshi S, Tomino Y, Ra C: Polymorphism in promoter region of Fc alpha receptor gene in patients with IgA nephropathy. Hum Genet, 108:128-133, 2001
  25. Nakano N, Shirasaka N, Kurihara M, Takamatsu M, Murakami T, Yoshizumi H, Tsuboi R, Ogawa H: Competitive incorporation of arachidonic acid analogs by cultured rat keratinocytes. J Nutr Sci Vitaminol, 47: 69-77, 2001
  26. Akaiwa M, Yu B, Umeshita-Suyama R, Terada N, Suto H, Koga T, Arima K, Matsushita S, Saito H, Ogawa H, Furue M, Hamasaki N, Ohshima K, Izuhara K: Localization of human interleukin 13 receptor in non-haematopoietic cells. Cytokine, 21;13:75-84, 2001
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 �y2000�z
  1. Goitsuka R, Kanazashi H, Sasanuma H, fujimura Y, Hidaka Y, Tatsuno A, Ra C, Hayashi K, Kitamura D: A BASH/SLP-76-related adaptor protein MIST/Clnk Involved in IgE receptor- mediated mast cell degranulation, Int Immunol, 12:573-580, 2000
  2. Shimokawa T, Tsuge T, Okumura K, Ra C: Identification and characterization of the promoter for the gene encoding the human myeloid IgA Fc receptor (FcaR, CD89), Immunogenetics, 51:945-954, 2000
  3. Tachimoto H, Ebisawa M, Hasegawa T, Kashiwabara T, Ra C, Bruce S.Bochner, Miura K, Saito H: Reciprocal regulation of cultured human mst cell cytokine producion by IL-4 and IFN-gammma, J Allergy Clin Immunol, 106:141-149, 2000
  4. Takai T, Yuuki T, Ra C: Inhibition of IgE-dependent histamine release from human peripheral blood basophils by humanized Fab fragments that recognize the membrane proximal domain of the human Fc epsilon RI alpha chain. Int Arch Allergy Immunol, 123:308-318, 2000
  5. Nakajima H, Nakao A, Kumano K, Yamamoto H, Iwamoto I: Systemic T helper 2 cell activation is not sufficient for antigen-induced eosinophil recruitment into the airways. Int Arch Allergy Immunol, 122 (S1):20-24, 2000
  6. Oishi Y, Sakamoto A, Kurasawa K, Nakajima H, Nakao A, Nakagawa N, Tanabe E, Saito Y, Iwamoto I: CD4-CD8- T cells bearing invariant V alpha 24J alpha Q TCR alpha-chain are decreased in patients with atopic diseases. Clin Exp Immunol, 119:404-411, 2000
  7. Umibe T, Kita Y, Nakao A, Nakajima H, Fukuda T, Yoshida S, Sakamaki T, Saito Y, Iwamoto I: Clonal expansion of T cells infilatrating in the airways of non-atopic asthmatics. Clin Exp Immunol, 119:390-397, 2000
  8. Yanagida M, Irikura M, Suto H, Yagi S, Ogawa H, Ra C: Kinetic Analysis of the Interaction between Recombinant Human Fc epsilon RI alpha and Serum IgEs from Allergic Patients. Clin Immunol, 95-3:190-196, 2000
  9. Hayashi S, Suto H, Wada N, Ogawa H, Okumura K, Ra C: Detection of anti-IgE and anti- Fc epsiron RI alpha chain auto-antibodies In patients with atopic dermatitis. Allergol Int, 49:47-54, 2000
  10. Nakao A, Miike S, Hatano M, Okumura K, Tokuhisa T, Ra C, Iwamoto I: Blockade of transforming growth factor beta/Smad signaling in T cells by overexpression of Smad7 enhances antigen-induced airway inflammation and airway reactivity. J Exp Med, 192:151-158, 2000.
  11. Akiba H, Miyahira Y, Atsuta M, Takeda K, Nohara C, Futagawa T, Matsuda H, Aoki T, Yagita H, Okumura,K: Critical contribution of OX40 ligand to T helper 2 cell differentiation in experimental leishmaniasis. J Exp Med, 191:375-380, 2000
  12. Honda Z, Suzuki T, Kono H, Okada M, Yamamoto T, Ra C, Morita Y, Yamamoto K: Sequential requirements of N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of Fc epsilon RI signaling. Molecular and Cellular Biol, 20:1759-1771, 2000
  13. Furumoto Y, Hiraoka S, Kawamoto K, Masaki S, Kitamura T, Okumura K, Ra C: Polymorphisms in Fc epsilon RI alpha Chain Do Not Affect IgE-Mediated Mast Cell Activation. Biochem Biophys Res Commun, 273:765-771, 2000
  14. Kumano K, Nakao A, Nakajima H, Miike S, Kurasawa K, Saito Y, Iwamoto I: Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways. Biochem Biophys Res Commun, 270:209-214, 2000
  15. Shimokawa T, Okumura K, Ra C: DNA Induces Apoptosis in Electroporated Human Promonocytic Cell Line U937. Biochem Biophys Res Commun, 270:94-99, 2000
  16. Mamura M, Nakao A, Goto D, Kato M, Saito Y, Iwamoto I: Ligation of the T cell receptor complex results in phosphorylation of Smad2 in T lymphocytes. Biochem Biophys Res Commun, 268:124-127, 2000
  17. Nishiyama C, Takahashi K, Nishiyama M, Okumura K, Ra C, Ohtake Y, Yokota T: Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription. -Molecular cloning of rat Elf-1. Biosci Biotechnol Biochem, 64:2601-7, 2000
  18. Takahashi K, Yuuki T, Takai T, Ra C, Yokota T, Okumura Y: Production of humanized Fab fragment against human high affinity IgE receptor in Pichia pastoris. Biosci Biotechnol Biochem, 64:2138-2144, 2000
  19. Takai T, Yuuki T, Iwamoto-Yasue N, Okumura K, Ra C: Epitope analysis and primary structures of variable regions of anti-human Fc epsilon RI monoclonal antibodies, and expression of the chimeric antibodies fused with human constant regions. Biosci Biotechnol Biochem, 64:1856-1867, 2000
  20. Asai K, Fujimoto K, Harazaki M, Kusunoki T, Korematsu S, Ide C, Ra C, Hosoi S: Distinct aggregation of beta-and gamma-chains of the high-affinity IgE receptor on crosslinking, J Histochem Cytochem, 48:1705-1715, 2000
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