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 �y2009�z
  1. Takai T, Vu AT, Le TA, Kinoshita H, Ushio H, Ikeda S, Ogawa H, Okumura K: Reply. J Allergy Clin Immunol, 124:864-865, 2009
  2. Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H: Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J Allergy Clin Immunol, 123:179-186, 2009
  3. Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K: Notch signaling confers antigen-presenting cell functions on mast cells. J Allergy Clin Immunol, 123:74-81.e1, 2009
  4. Takai T, Kato T, Hatanaka H, Inui K, Nakazawa T, Ichikawa S, Mitsuishi K, Ogawa H, Okumura K: Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand. J Immunol, 183:7958-7965, 2009
  5. Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S: Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J Immunol, 183:7890-7897, 2009
  6. Kamijo S, Takai T, Kuhara T, Tokura T, Ushio H, Ota M, Harada N, Ogawa H, Okumura K: Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo. J Immunol, 183:6087-94, 2009
  7. Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A: A subcytotoxic dose of subtilase cytotoxin prevents lipopolysaccharide-induced inflammatory responses, depending on its capacity to induce the unfolded protein response. J Immunol, 183:1268-1274, 2009
  8. Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A: Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol, 39:3078-3083, 2009
  9. Niyonsaba F, Nagaoka I, Ogawa H, Okumura K: Multifunctional antimicrobial proteins and peptides: Natural activators of immune systems. Curr Pharm Des, 15: 2393-2413, 2009
  10. Potaczek D, Okumura K, Nishiyama C: FCER1A genetic variability and serum IgE levels. Allergy, 64:1383, 2009
  11. Kato T, Takai T, Fujimura T, Matsuoka H, Ogawa T, Murayama K, Ishii A, Ikeda S, Okumura K, Ogawa H: Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes. Allergy, 64:1366-1374, 2009
  12. Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H: Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids. Allergy, 64:1231-1232, 2009
  13. Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, Kanada S, Fukuyama K, Akiba H, Tokura T, Hara M, Tsuboi R, Ogawa H, Okumura K: Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma. Int Immunol, 21:803-816, 2009
  14. Shimokawa N, Nishiyama C, Hirota T, Tamari M, Hara M, Ikeada S, Okumura K, Ogawa H: Functional analysis of a polymorphism in the promoter region of the IL-12⁄23p40 gene. Clin Exp Allergy, 39:228-235, 2009
  15. Potaczek D, Maeda K, Wang Q-h, Nakano N, Kanada S, Stepien E, Branicka A, Fukai T, Hara M, Tokura T, Ogawa H, Undas A, Okumura K, Nishiyama C: FcepsilonRIalpha gene -18483 A>C polymorphism affects transcriptional activity through YY1 binding. Immunogenetics, 61:649-655, 2009
  16. Potaczek D, Nishiyama C, Sanak M, Szczeklik A, Okumura K: Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha). Immunol Res, 45:75-84, 2009
  17. Ichikawa S, Takai T, Yashiki T, Takahashi S, Okumura K, Ogawa H, Kohda D, Hatanaka H: Lipopolysaccharide binding of the mite allergen Der f 2. Genes Cells, 14:1055-1065, 2009
  18. Nakamura Y, Miyata M, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity. FEBS Lett, 583:2088-2092, 2009
  19. Fukai T, Nishiyama C, Kanada S, Nakano N, Hara M, Tokura T, Ikeda S, Ogawa H, Okumura K: Involvement of PU.1 in the transcriptional regulation of TNF-alpha. Biochem Biophys Res Commun, 388:102-106, 2009
  20. Wang XL, Takai T, Kamijo S, Gunawan H, Ogawa H, Okumura K: NADPH oxidase activity in allergenic pollen grains of different plant species. Biochem Biophys Res Commun, 387:430-434, 2009
  21. Seto T, Takai T, Ebihara N, Matsuoka H, Wang XL, Ishii A, Ogawa H, Murakami A, Okumura K: SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells. Biochem Biophys Res Commun, 379:681-685, 2009
  22. Nakamura Y, Miyata M, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A: The latent form of transforming growth factor-beta administered orally is activated by gastric acid in mice. J Nutr, 139:1463-1468, 2009
  23. Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K: The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol, 160:243-249, 2009
  24. Ng W, Nishiyama C, Mizoguchi M, Ikeda S, Okumura K, Ogawa H. Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1. J Dermatol Sci, 54:131-134, 2009
  25. Suzuki K, Kaminuma O, Yang L, Motoi Y, Takai T, Ichikawa S, Okumura K, Ogawa H, Mori A, Takaiwa F, Hiroi T: Development of transgenic rice expressing mite antigen for a new concept of immunotherapy. Int Arch Allergy Immunol, 149 Suppl 1:21-24, 2009
  26. Takai T, Ochiai Y, Ichikawa S, Sato E, Ogawa T, Tokura T, Kuhara T, Kawai H, Hatanaka H, Takakhashi S, Ogawa H, Okumura K: Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: Useful tool for study of allergies in mouse models. Allergol Int, 58:225-235, 2009
  27. Ebihara N, Nakayama M, Tokura T, Iwatsu M, Ushio H, Murakami A: Proinflammatory effect of TWEAK⁄Fn14 interaction in human retinal pigment epithelial cells. Curr Eye Res, 34:836-844, 2009
  28. Ebihara N, Nakayama M, Tokura T, Ushio H, Murakami A: Expression and function of fibroblast growth factor-inducible 14 in human corneal myofibroblasts. Exp Eye Res, 89:256-262, 2009
  29. Yoshioka M, Sagara H, Takahashi F, Harada N, Nishio K, Mori A, Ushio H, Shimizu K, Okada T, Ota M, Ito YM, Nagashima O, Atsuta R, Suzuki T, Fukuda T, Fukuchi Y, Takahashi K: Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol, 296:L30-36, 2009
  30. Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K: Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo. Phytother Res, 23:1581-1586, 2009
  31. Potaczek D, Pieculewicz M, Mazur M, Branicka A, Nishiyama C, Okumura K, Undas A: Tissue factor (TF) +5466A>G polymorphism predicts plasma TF levels in subjects with cryptogenic ischemic stroke. Thromb Haemost, 102:173-175, 2009
  32. Potaczek D, Nishiyama C, Undas A, Okumura K: Tissue factor genetic polymorphisms and haplotypes in Japanese population. Atherosclerosis, 207:344-345, 2009
  33. Potaczek D, Wang Q-h, Sanak M, Tokura T, Matsuda H, Dziedzina S, Nakano N, Hara M, Ogawa H, Szczeklik A, Okumura K, Nishiyama C: Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes. Tissue Antigens, 74:534-538, 2009
  34. Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M: Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. Nat Chem Biol, 5:673-679, 2009
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 �y2008�z  
  1. Zabel BA, Nakae S, Zunigav L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Galli SJ, Butcher EC: Mast Cell-Expressed Orphan Receptor CCRL2 Binds Chemerin and is Required for Optimal Induction of IgE-Mediated Passive Cutaneous Anaphylaxis. J Exp Med, 205:2207-2220�C2008
  2. Kanada S, Nakano N, Potaczek D, Maeda K, Shimokawa N, Niwa Y, Fukai T, Sanak M, Szczeklik A, Yagita H, Okumura K, Ogawa H, and Nishiyama C: Two different transcription factors discriminate the -315C>T-polymorphism of the FcepsilonRIalpha gene: Binding of Sp1 to -315C and of a high mobility group-related molecule to -315T. J Immunol, 180:8204-8210�C2008
  3. Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Suto H, Ogawa H, Masuyama K, Nakao A: Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis. Eur J Immunol, 38:1487-1492�C2008
  4. Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M: Evaluation of the effect of human beta-defensins on neutrophil apoptosis. Int Immunol, 20:543-553�C2008
  5. Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H: Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology, 124:357-367�C2008
  6. Wang QH, Nishiyama C, Nakano N, Shimokawa N, Hara M, Kanada S, Ogawa H, and Okumura K: Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells. Immunogenetics, 60:557-563, 2008
  7. Gunawan H, Takai T, Ikeda S, Okumura K, Ogawa H: Protease activity of allergenic pollen of cedar, cypress, juniper, birch, and ragweed. Allergol Int, 57:83-91, 2008
  8. Potaczek D, Nishiyama C, Sanak M, Szczeklik A, Okumura K, and Ogawa H: FCER1A gene exon 1A polymorphisms in Japanese and Polish subjects - a comparative analysis of haplotypes. Allergy, 63:626-627�C2008
  9. Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H: Upregulation of release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol, 146:27-35,2008
  10. Nakano N, Nishiyama C, Tokura T, Nagasako-Akazome Y, Ohtake Y, Okumura K, Ogawa H: Procyanidin C1 from Apple Extracts Inhibits FcepsilonRI-Mediated Mast Cell Activation. Int Arch Allergy Immunol�C147:213-221�C2008
  11. Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H: Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains. Int Arch Allergy Immunol�C147:276-288�C2008
  12. Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A: Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation. J Allergy Clin Immun, 122:1208-1214, 2008
  13. Potaczek D, Sanak M, Nishiyama C, Okumura K, Ogawa H, Szkzeklik A: FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians. Int J Immunogenet, 35:339-340, 2008
  14. Itoh Y, Nishida C, Tokiwa N, Satoh K, Tokura T, Maeda K: The determination of Lewis and secretor-nonsecretor functonal alleles for clinical application of urinary CA19-9. Forensic Science International: Genetics Supplement Series, 1:565-568, 2008
  15. Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama J, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H: Fusion of One twenty-two to BSAC results in aberrant upregulation of transcriptional activity. J Biol Chem�C283:26820-26828�C2008
  16. Suenaga F, Hatsushika K, Takano S, Ando T, Ohnuma Y, Ogawa H, Nakao A: A possible link between resveratrol and TGF-beta: resveratrol induction of TGF-beta expression and signaling. FEBS Lett, 582:586-590, 2008
  17. Jayawardana TMS, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H: Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun, 365:137-142, 2008
  18. Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, Nakao A: T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability. Biochem Biophys Res Commun, 371:762-766, 2008
  19. Niwa Y, Nishiyama C, Nakano N, Kamei A, Kato H, Kanada S, Ikeda S, Ogawa H, and Okumura K: Opposite effects of PU.1 on mast cell stimulation. Biochem Biophys Res Commun, 375:95-100�C2008
  20. Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Katoh R, Ogawa H, Hamada Y, Nakao A: A potential role of TSLP in the recruitment of macrophages to the intervertebral disc via MCP-1 induction: The implications in a herniated disc. Arthritis Rheum, 58:3510-3519, 2008
  21. Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, and Ogawa H: Human umbilical cord epithelial cells express Notch1: Implication for its epidermal-like differentiation. J Dermatol Sci, 49:143-152�C2008
  22. Niyonsaba F, Hattori F, Maeyama K, Ogawa H, Okamoto K: Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes. J Dermatol Sci, 52:216-219�C2008
  23. Takagi A, Nishiyama C, Maeda K, Tokura T, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, and Ogawa H: Role of Sp1 in transcription of human ATP2A2 gene promoter in keratinocytes. J Invest Dermatol, 128:96-103�C2008
  24. Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, YamamotoY, Tadokoro T, Okumura K, Ogawa H: Inhibitory Effect of Honeybee-Collected Pollen on Mast Cell Degranulation in vivo and in vitro. J Med Food�C11:14-20�C2008
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 �y2007�z  
  1. Nakae S, Suto H, Berry GJ, Galli SJ: Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood, 109:3640-3648, 2007
  2. Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K, Ogawa H: Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood, 109:4846-4855, 2007
  3. Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH and Galli SJ: TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood, 110:2565-2568, 2007
  4. Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Antimicrobial peptides human beta-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol, 37:434-444, 2007
  5. Sakuma M, Hatsushika K, Koyama K, Katoh R, Ando T, Watanabe Y, Wako M, Kanzaki M, Takano S, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A: TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol, 19:117-126, 2007
  6. Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A: Transforming Growth Factor-beta2 polymorphisms are associated with childhood atopic asthma. Clin Exp Allergy, 37:1165-1174, 2007
  7. Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H, Galli SJ: Mast cell-derived TNF contributes to airway hyperreactivity,inflammation, and T(H)2 cytokine production in an asthma model in mice. J Allergy Clin Immunol, 120:48-55, 2007
  8. Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Luo J, Wyss-Coray T, Nakao A: Orally administered TGF-beta is biologically active in the intestinal mucosa and enhances oral tolerance. J Allergy Clin Immunol, 120:916-923, 2007
  9. Kanzaki M, Shibagaki N, Hatsushika K, Mitsui H, Inozume T, Okamoto A, Dobashi Y, Ogawa H, Shimada S, Nakao A: Human eosinophils have an intact Smad signaling pathway leading to a major transforming growth factor-beta target gene expression. Int Arch Allergy Immunol, 142:309-317, 2007
  10. Koyama K, Ozawa T, Hatsushika K, Ando T, Takano S, Wako M, Suenaga F, Ohnuma Y, Ohba T, Katoh R, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A: A possible role for TSLP in inflammatory arthritis. Biochem Biophys Res Commun, 357:99-104, 2007
  11. Takano S, Kanai F, Jazag A, Ijichi H, Yao J, Ogawa H, Enomot oN, Omata M, Nakao A: Smad4 is essential for down-regulation of E-cadherin induced by TGF-beta in pancreatic cancer cell line PANC-1. J Biochem, 141:345-351, 2007
  12. Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, Ogawa H: Human umbilical cord epithelial cells express Notch1: Implications for its epidermal-like differentiation. J Dermatol Sci, 49:143-152, 2007
  13. Hasegawa T, Sumiyoshi K, Tsuchihashi H, Ikeda S, Nakao A, Ogawa H: FK506 inhibits the enhancing effects of TGF-beta on wound healing in a rabbit dermal ulcer model. J Dermatol Sci, 47:37-40, 2007
  14. Tsuchihashi H, Hasegawa T, Sumiyoshi K, Ogawa H, Ikeda S, Ando T, Nakao A, Okumura K: TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel. J Dermatol Sci, 45:216-218, 2007
  15. Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils. Br J Dermatol, 157:1124-1131, 2007
  16. Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H: Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol, 127:594-604�A2007
  17. Takagi A, Nishiyama C, Maeda K, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, Ogawa H: Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes. J Invest Dermatol, 128:96-103, 2007
  18. Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana STM, Ikeda S, Okumura K, Ogawa H: The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor4. J Leukoc Biol, 82:657-665, 2007
  19. Nakae S, Iwakura Y, Suto H, Galli SJ: Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol, 81:1258-1268, 2007
  20. Ho LH, Ohno T, Suto H, Iikura M, Akira S, Okayama Y, Saito H, Galli SJ and Nakae S: IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol, 82:1481-1490, 2007
  21. Iikura M, Suto H, Kajiwara N, Oboki K, Ohono T, Okayama Y, Saito H, Galli SJ, Nakae S: IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab Invest, 87:971-978, 2007
  22. Koyama K, Hatsushika K, Ando T, Sakuma M, Wako M, Kato R, Sugiyama H, Hamada Y, Ogawa H, Nakao A: Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice. Mod Rheumatol, 17:306-310, 2007
  23. Ebihara N, Yamagami S, Chen L, Tokura T, Iwatsu M, Ushio H, Murakami A: Expression and function of Toll-like receptor-3 and -9 in human corneal myofibroblasts. Invest Ophthalmol Vis Sci, 48:3069-3076, 2007
  24. Ebihara N, Chen L, Tokura T, Ushio H, Iwatsu M, Murakami A: Distinct functions between Toll-like receptors 3 and 9 in retinal pigment epithelial cells. Ophthalmic Res, 39:155-163, 2007
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 �y2006�z
  1. Maeda K, Nishiyama C, Tokura T, Nakano H, Kanada S, Nishiyama M, Okumura K, and Ogawa H: FOG-1 represses GATA-1-dependent Fc epsilon RI beta-chain transcription:transcriptional mechanism of mast cell-specific gene expression in mice. Blood, 108:262-268, 2006
  2. Kikuchi Y, Takai T, Kuhara T, Ota M, Kato T, Hatanaka H, Ichikawa S, Tokura T, Akiba H, Mitsuishi K, Ikeda S, Okumura K, Ogawa H: Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p 1 to sensitization towards IgE and IgG responses. J Immunol, 177:1609-1617, 2006
  3. Suto H, Nakae S, Kakurai M, Sedwick JD, Tsai M, Galli SJ: Mast cell-associated TNF promotes dendritic cell migration. J Immunol, 176:4102-12, 2006
  4. Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick JD, Tsai M, Galli SJ: Mast cells enhance T cell activation: Importance of mast cell co-stimulatory molecules and secreted TNF. J Immunol, 176:2238-48, 2006
  5. Niyonsaba F, Nagaoka I, Ogawa H: Human degensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit Rev Immunol, 26:545-76, 2006
  6. Kikuchi Y, Takai T, Ota M, Kato T, Takeda K, Mitsuishi K, Ikeda S, Okumura K, Ogawa H: Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin. Int Arch Allergy Immunol, 141:322-30,2006
  7. Takai T, Mizuuchi E, Kikuchi Y, Nagamune T, Okumura K, Ogawa H: Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation. Int Arch Allergy Immunol, 139:181-187, 2006
  8. Yokoi H, Okayama Y, Niyonsaba F, Fujimori M, Enomoto F, Yoshikawa H, Ikeda K, Saito H: Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors. Allergy Asthma Proc, 27:415-21,2006
  9. Kakurai M, Monteforte R, Suto H, Tsai M, Nakae S and Galli SJ: Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice. Am J Pathol, 169:1713-1721, 2006
  10. Takagi A, Nishiyama C, Kanada S, Niwa Y, Fukuyama K, Ikeda S, Okumura K and Ogawa H: Prolonged MHC class II expression and CIITA transcription in human keratinocytes. Biochem Biophys Res Commun, 347:388-393, 2006
  11. Nishiyama C: Molecular mechanism of allergy-related gene regulation and hematopoietic cell development by transcription factors. Biosci Biotechnol Biochem, 70:1-9, 2006
  12. Nakamura T, Hirasawa Y, Takai T, Mitsuishi K, Okuda M, Kato T, Okumura K, Ikeda S, Ogawa H: Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite allergen Der f 1. J Invest Dermatol, 126:2719-2723, 2006
  13. Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci, 43:63-66, 2006
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 �y2005�z
  1. Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H: The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 kinase and ERK MAPK activation in primary human keratinocytes. J Immunol, 175:1776-84, 2005
  2. Kanamaru Y, Sumiyoshi K, Ushio H, Ogawa H, Okumura K, Nakao A: Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis. J Immunol, 174:4193-4197, 2005
  3. Ito T, Nishiyama C, Nishiyama M, Matsuda H, Maeda K, Akizawa Y, Tsuboi R, Okumura K, Ogawa H: Mast cells acquire monocyte-specific gene expression and monocyt e-like morphology by overproduction of PU.1. J Immunol, 174:376-383, 2005
  4. Kato T, Takai T, Mitsuishi K, Okumura K, Ogawa H: Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: Biochemical skin-barrier against mite cysteine proteases. J Allergy Clin Immunol, 116:169-76, 2005
  5. Takai T, Kato T, Yasueda H, Okumura K, Ogawa H: Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: Major conformational IgE-epitopes blocked by prodomains. J Allergy Clin Immunol, 115:555-563, 2005
  6. Nishiyama C, Ito T, Nishiyama M, Masaki S, Maeda K, Nakano N, Ng W, Fukuyama K, Yamamoto M, Okumura K, Ogawa H: GATA-1 is required for expression of Fc epsilon RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow. Int Immunol, 17:847-856, 2005
  7. Okamoto A, Kawamura T, Kanbe K, Kanamaru Y, Ogawa H, Okumura K, Nakao A: Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-beta. Int Immunol, 17:705-712, 2005
  8. Miyahira Y, Takashima Y, Kobayashi S, Matsumoto Y, Takeuchi T, Ohwada A, Yoshida A, Akiba H, Yagita H, Okumura K and Ogawa H: Immune responses toward a single CD8+ T cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection. Infect Immun, 73: 7356-7365, 2005
  9. Nakano N, Nishiyama C, Masuoka N, Nishiyama M, Yamane H, Okumura K, Ogawa H: Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: Molecular cloning of rat Icsbp (Irf-8) cDNA. Immunogenetics, 56:871-7, 2005
  10. Mitsuishi K, Nakamura T, Sakata Y, Yuyama N, Arima K, Sugita Y, Suto H, Izuhara K, Ogawa H: The squamous cell carcinoma antigens as relevant biomarkers of atopic dermatitis. Clin Exp Allergy, 35:1327-33, 2005
  11. Takai T, Kato T, Ota M, Yasueda H, Kuhara T, Okumura K, Ogawa H: Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25, and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice. Int Arch Allergy Immunol, 194-200, 2005
  12. Takai T, Takaoka M, Yasueda H, Okumura K, Ogawa H: Dilution-method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens. Int Arch Allergy Immunol, 137:1-8, 2005
  13. Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K: Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization. J Exp Med, 202:739-50, 2005
  14. Ohki Y, Heissig B, Sato Y, Akiyama H, Zhu Z, Hicklin DJ, Shimada K, Ogawa H, Daida H, Hattori K, Ohsaka A: Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils. FASEB J, 19:2005-7, 2005
  15. Nakae S, Suto H, Kakurai M, Sedgwick JD, Tsai M, Galli SJ: Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci U S A. 102:6467-72, 2005
  16. Tubouchi T, Mineki R, Taka H, Kaga N, Murayama K, Nishiyama C, Yamane H, Kuzuyama T, Nishiyama M: Leader peptide-mediated transcriptional attenuation of lysine biosynthetic gene cluster in Thermus thermophilus. J Biol Chem, 280:18511-6, 2005
  17. Nakazawa T, Takai T, Hatanaka H, Mizuuchi E, Nagamune T, Okumura K, Ogawa H: Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure. FEBS Lett, 579:1988-1994, 2005
  18. Takai T, Kato T, Sakata Y, Yasueda H, Izuhara K, Okumura K, Ogawa H: Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity. Biochem Biophys Res Commun, 328:944-52, 2005
  19. Nakano N, Nakao A, Uchida T, Shirasaka N, Yoshizumi H, Okumura K, Tsuboi R, Ogawa H: Effects of arachidonic acid analogs on FcepsilonRI-mediated activation of mast cells. Biochim Biophys Acta, 1738:19-28, 2005
  20. Ichikawa S, Takai T, Inoue T, Yuuki T, Okumura Y, Ogura K, Inagaki F, Hatanaka H: NMR study on the major mite allergen Der f 2: Its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members. J Biochem, 137:255-263, 2005
  21. Tokura T, Nakano N, Ito T, Matsuda H, Nagasako-Akazome Y, Kanda T, Ikeda M, Okumura K, Ogawa H, Nishiyama C: Inhibitory effect of polyphenol-enriched apple extracts on mast cell degranulation in vitro targeting the binding between IgE and Fc epsilon RI. Biosci Biotechnol Biochem, 69:1974-1977, 2005
  22. Kawada H, Nishiyama C, Takagi A, Tokura T, Nakano N, Maeda K, Mayuzumi N, Ikeda S, Okumura K, Ogawa H: Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes. J Invest Dermatol, 124:1206-14, 2005
  23. Nakano N, Ishidoh K, Nakao A, Tsuboi R, Kominami E, Okumura K, Ogawa H: CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. Br J Dermatol, 153:37-45, 2005
  24. Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H: Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci, 40:123-32, 2005
  25. Niyonsaba F, Ogawa H: Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci, 40:157-68, 2005
  26. Hasegawa T, Nakao A, Sumiyoshi K, Tsuchihashi H, Ogawa H: SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts. J Dermatol Sci, 39:33-8, 2005
  27. Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H: The effect of antibacterial peptide human beta-defensin-2 on interleukin-18 secretion by keratinocytes. J Dermatol Sci, 37:188-91, 2005
  28. Titapiwatanakun B, Miyahira Y, Mayuzumi N, Ogawa H and Ikeda S: SCCA2-transfected human keratinocytes show increased secretion of IL-1alpha and IL-6, but not of TNF-alpha. Arch Dermatol Res, 297:274-7, 2005
  29. Lee K D, Yamataka A, Kato Y, Kobayashi H, Lane G J, Maeda K, Kojima Y, Sueyoshi N, and Miyano T : Graft serosectomy in adult small bowel transplantation without vascular reconstruction in rats improves graft survival by induction of vascular endothelial growth factor. J Pediatr Surg, 40.1881-1886, 2005
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