Department of Nephrology
Research
Basic research is divided into three groups: the inflammatory renal disease group with IgA nephropathy as the main research topic, the diabetic nephropathy group and the end-stage renal failure group.
Recent years in this country, about 30,000 patients a year develop chronic renal failure and are placed hemodialysis or peritoneal dialysis and this number tends to increase every year. We hope to clarify as soon as possible the mechanisms of onset and progression of diabetic nephropathy, the main underlying disease of end-stage renal failure and IgA nephropathy, which accounts for more than half of patients with chronic glomerulonephritis. Research is performed using molecular biology techniques to understand these diseases with consideration given to feedback from basic research to clinical practice, which is considered to be an obligation of clinicians. The current research activities of each of the groups are briefly outlined.
Recent years in this country, about 30,000 patients a year develop chronic renal failure and are placed hemodialysis or peritoneal dialysis and this number tends to increase every year. We hope to clarify as soon as possible the mechanisms of onset and progression of diabetic nephropathy, the main underlying disease of end-stage renal failure and IgA nephropathy, which accounts for more than half of patients with chronic glomerulonephritis. Research is performed using molecular biology techniques to understand these diseases with consideration given to feedback from basic research to clinical practice, which is considered to be an obligation of clinicians. The current research activities of each of the groups are briefly outlined.
Research Group for Inflammatory Renal Disease
1) Analyses for Pathogenesis of IgA Nephropathy
- Analyses for Susceptibility Genes in Spontaneous Murine IgA Nephropathy Model (ddY mice)
- Analyses for Candidate Genes in Human IgA Nephropathy
- Analyses for Roles of Mucosal Immunity in IgA Nephropathy
- Analyses for IgA Molecules from Serum and Glomeruli of Human IgA Nephropathy
- Analyses for roles of rennin angiotensin system in immune-mediated glomerulonephritis
- Analyses for roles of immunoglobulin receptor (FcR) in glomerulonephritis
4) Histological detection of CC and CRP
5) DNA polymorphism and its functional abnormalities of CRP
6) The mechanism of the complement activation by hemodialysis membrane
Research Group for Chronic Kidney Disease
Analyses for the development and progression of diabetic nephropathy
- Analyses for susceptibility genes in type 2 diabetic KK mice using QTL mapping
- Analyses for candidate genes in human diabetic nephropathy
- Analyses for roles of insulin resistance and oxidative stress via AGEs in diabetic nephropathy
- Analyses for roles of various drug (ARB, HMG-CoA, PPAR) in diabetic nephropathy using KKAy and KK mice.
Research Group for Chronic Kidney Disease
1) Analyses for the development of Peritoneal Sclerosis
- Analyses for Pathogenesis of Peritoneal Sclerosis (PS) in Peritoneal Dialysis Patients
- Analyses for morphologic and functional changes of Peritoneal Sclerosis in PS animal models
- Analyses for morphologic changes in Peritoneal Repair
- Approaches to peritoneal regeneration in PS animal models
- Analyses for Physiologic indicator of the Clinical Course in CKD patients
- Analyses for Calcium Metabolism in CKD patients
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