Juntendo University, Tokyo, established in 1838.

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Department of Nephrology

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Achievements (2014)

|2014|20132012
  1. Adipose-derived mesenchymal stem cells transplantation facilitate experimental peritoneal fibrosis repair by suppressing epithelial-mesenchymal transition. Wakabayashi K, Hamada C, Kanda R, Nakano T, Io H, Horikoshi S, Tomino Y. J Nephrol. 2014
  2. Impact of Body Mass Index on Progression of IgA Nephropathy Among Japanese Patients. Shimamoto M, Ohsawa I, Suzuki H, Hisada A, Nagamachi S, Honda D, Inoshita H, Shimizu Y, Horikoshi S, Tomino Y. J Clin Lab Anal. 2014
  3. Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy. Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y. BMC Nephrol. 2014 ;15:89
  4. Fluctuation of serum C3 levels reflects disease activity and metabolic background in patients with IgA nephropathy: response to comment. Tomino Y. J Nephrol. 2014
  5. Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage. Nagamachi S, Ohsawa I, Suzuki H, Sato N, Inoshita H, Hisada A, Honda D, Shimamoto M, Shimizu Y, Horikoshi S, Tomino Y. BMC Nephrol. 2014 ;15:82
  6. A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases. Yanagawa H, Suzuki H, Suzuki Y, Kiryluk K, Gharavi AG, Matsuoka K, Makita Y, Julian BA, Novak J, Tomino Y. PLoS One. 2014 ;9:e98081
  7. Effect of AST-120 on Endothelial Dysfunction in Adenine-Induced Uremic Rats. Inami Y, Hamada C, Seto T, Hotta Y, Aruga S, Inuma J, Azuma K, Io H, Kaneko K, Watada H, Tomino Y. Int J Nephrol. 2014 ;2014:164125
  8. Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy. Aizawa M, Suzuki Y, Suzuki H, Pang H, Kihara M, Nakata J, Yamaji K, Horikoshi S, Tomino Y. PLoS One. 2014 ;9:e95365
  9. Impacts of recombinant human erythropoietin treatment during predialysis periods on the progression of chronic kidney disease in a large-scale cohort study (Co-JET study). Akizawa T, Saito A, Gejyo F, Suzuki M, Nishizawa Y, Tomino Y, Tsubakihara Y, Akiba T, Hirakata H, Watanabe Y, Kawanishi H, Bessho M, Udagawa Y, Aoki K, Uemura Y, Ohashi Y; Co-JET Study Group. Ther Apher Dial. 2014 ;18:140-8
  10. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ishimitsu T, Ito M, Ito S, Itoh H, Iwao H, Kai H, Kario K, Kashihara N, Kawano Y, Kim-Mitsuyama S, Kimura G, Kohara K, Komuro I, Kumagai H, et al. Hypertens Res. 2014 ;37:253-387
  11. Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy. Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y. Biochem Biophys Res Commun. 2014 ;446:1190-6
  12. Role of the TNF pathway in the progression of diabetic nephropathy in KK-A(y) mice. Omote K, Gohda T, Murakoshi M, Sasaki Y, Kazuno S, Fujimura T, Ishizaka M, Sonoda Y, Tomino Y. Am J Physiol Renal Physiol. 2014 ;306:F1335-47
  13. A multicenter randomized controlled trial of tonsillectomy combined with steroid pulse therapy in patients with immunoglobulin A nephropathy. Kawamura T, Yoshimura M, Miyazaki Y, Okamoto H, Kimura K, Hirano K, Matsushima M, Utsunomiya Y, Ogura M, Yokoo T, Okonogi H, Ishii T, Hamaguchi A, Ueda H, Furusu A, Horikoshi S, Suzuki Y, Shibata T, Yasuda T, Shirai S, Imasawa T, Kanozawa K, et al. Nephrol Dial Transplant. 2014 ;29:1546-53
  14. Dietary zinc is a key environmental modifier in the progression of IgA nephropathy. Maiguma M, Suzuki Y, Suzuki H, Okazaki K, Aizawa M, Muto M, Tomino Y. PLoS One. 2014 ;9:e90558
  15. Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy. Nakata J, Suzuki Y, Suzuki H, Sato D, Kano T, Yanagawa H, Matsuzaki K, Horikoshi S, Novak J, Tomino Y. PLoS One. 2014 ;9:e89707
  16. Low Hemoglobin Levels and Hypo-Responsiveness to Erythropoiesis-Stimulating Agent Associated With Poor Survival in Incident Japanese Hemodialysis Patients. Akizawa T, Saito A, Gejyo F, Suzuki M, Nishizawa Y, Tomino Y, Tsubakihara Y, Akiba T, Hirakata H, Watanabe Y, Kawanishi H, Bessho M, Udagawa Y, Aoki K, Uemura Y, Ohashi Y; JET Study Group. Ther Apher Dial. 2014
  17. Notch2 activation ameliorates nephrosis. Tanaka E, Asanuma K, Kim E, Sasaki Y, Oliva Trejo JA, Seki T, Nonaka K, Asao R, Nagai-Hosoe Y, Akiba-Takagi M, Hidaka T, Takagi M, Koyanagi A, Mizutani S, Yagita H, Tomino Y. Nat Commun. 2014 ;5:3296
  18. Suppressive effects of iron overloading on vascular calcification in uremic rats. Seto T, Hamada C, Tomino Y. J Nephrol. 2014 ;27:135-42
  19. Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy. Suzuki Y, Matsuzaki K, Suzuki H, Okazaki K, Yanagawa H, Ieiri N, Sato M, Sato T, Taguma Y, Matsuoka J, Horikoshi S, Novak J, Hotta O, Tomino Y. Clin Exp Nephrol. 2014
  20. The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study. Hosoya T, Kimura K, Itoh S, Inaba M, Uchida S, Tomino Y, Makino H, Matsuo S, Yamamoto T, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H. Trials. 2014 ;15:26
  21. Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes. Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG, Novak J. J Biol Chem. 2014 ;289:5330-9
  22. Accumulation of advanced glycation end products and beta 2-microglobulin in fibrotic thickening of the peritoneum in long-term peritoneal dialysis patients. Nakamoto H, Hamada C, Shimaoka T, Sekiguchi Y, Io H, Kaneko K, Horikoshi S, Tomino Y. J Artif Organs. 2014 ;17:60-8
  23. Comparison between the fixation of peritoneal dialysis catheters to the peritoneal wall and the conventional placement technique: clinical experience and follow-up of a new implant technique for peritoneal dialysis catheters. Io H, Maeda K, Sekiguchi Y, Shimaoka T, Aruga S, Nakata J, Nakamoto H, Hotta Y, Koyanagi I, Inaba M, Kanda R, Nakano T, Wakabayashi K, Sasaki Y, Inuma J, Kaneko K, Hamada C, Fukui M, Tomino Y. Semin Dial. 2014 ;27:E42-7
  24. Paracrine effects of transplanted mesothelial cells isolated from temperature-sensitive SV40 large T-antigen gene transgenic rats during peritoneal repair. Kanda R, Hamada C, Kaneko K, Nakano T, Wakabayashi K, Hara K, Io H, Horikoshi S, Tomino Y. Nephrol Dial Transplant. 2014 ;29:289-300
  25. Overestimation of the risk of progression to end-stage renal disease in the poor prognosis' group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy. Miyazaki Y, Kawamura T, Joh K, Okonogi H, Koike K, Utsunomiya Y, Ogura M, Matsushima M, Yoshimura M, Horikoshi S, Suzuki Y, Furusu A, Yasuda T, Shirai S, Shibata T, Endoh M, Hattori M, Akioka Y, Katafuti R, Hashiguchi A, Kimura K, Matsuo S, et al. Clin Exp Nephrol. 2014 ;18:475-80
  26. Proposal of remission criteria for IgA nephropathy. Suzuki Y, Matsuzaki K, Suzuki H, Sakamoto N, Joh K, Kawamura T, Tomino Y, Matsuo S. Clin Exp Nephrol. 2014 ;18:481-6
  27. Hyaline vascular type of unicentric Castleman's disease with proliferation of glomerular endothelial cells. Wakabayashi K, Asanuma K, Takeda Y, Arakawa A, Osawa I, Horikoshi S, Yao T, Tomino Y. Clin Nephrol. 2014 ;81:445-50
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