YOKOMIZO Takehiko, M.D., Ph.D.

Department of Molecular and Cellular Biochemistry

Short Biography

M.D. The University of Tokyo Faculty of Medicine
Ph.D. The University of Tokyo Graduate School of Medicine
Postdoctoral Fellow (JSPS Fellow), The University of Tokyo
Research Associate, The University of Tokyo
Associate Professor, The University of Tokyo
Professor, Kyushu University
Professor, Department of Molecular and Cellular Biochemistry, Juntendo University Faculty of Medicine
Program Officer, AMED

Main Research Topics and Interests

  • Lipid mediators (Leukotriene, Prostaglandin)
  • G-protein coupled receptor
  • Signal transduction
  • Immune response
  • Knockout mice

Publications (in English)

  • Original Articles (104)
  • Review Articles (24)
  • Books (28)
  • Total Citations (11,112)
  • Average Citations (71.2)

Recent Main Publications

  • Yokomizo T., M. Nakamura, T. Shimizu.  Leukotriene receptors as potential therapeutic targets. J. Clin. Invest. 128, 2691-2701 (2018)
  • Hirakata T., H.C. Lee, M. Ohba, K. Saeki, T. Okuno, A. Murakami, A. Matsuda, T. Yokomizo.  Dietary omega-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses. FASEB J. 33, 3392-3403 (2019)
  • Sasaki F., T. Koga, M. Ohba, K. Saeki, T. Okuno, K. Ishikawa, T. Nakama, S. Nakao, S. Yoshida, T. Ishibashi, H. Ahmadieh, M.R. Kanavi, A. Hafezi-Moghadam, J.M. Penninger, K.H. Sonoda, T. Yokomizo.  Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight 3, 96902 (2018)
  • Hori T., T. Okuno, K. Hirata, K. Yamashita, Y. Kawano, M. Yamamoto, M. Hato, M. Nakamura, T. Shimizu, T. Yokomizo, M. Miyano, S. Yokoyama.  Na(+)-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1. Nat. Chem. Biol. 14, 262-269 (2018)
  • Iwamoto S., T. Koga, M. Ohba, T. Okuno, M. Koike, A. Murakami, A. Matsuda, T. Yokomizo.  Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. Sci Rep 7, 13267 (2017)
  • More

Other Specific Comments

  • Prof. Yokomizo is famous for his cloning of leukotriene B4 receptors (Nature 1997 and JEM 2000). He is a leader of lipid research in Japan, and mainly working on GPCRs on lipid mediators using biochemistry, immunology and gene targeting. English-speaking ability is required.