学校法人順天堂　研究者情報データベース:::研究業績詳細:::

HOME　＞　研究業績詳細

研究業績詳細

横山和正（ヨコヤマカズマサ）

研究テーマ	神経免疫疾患
研究業績（論文）	Cossu D, Ruberto S, Yokoyama K, Hattori N, Sechi LA. Efficacy of BCG vaccine in animal models of neurological disorders. Vaccine. 2022 Jan 24;40(3):432-436. Hoshino Y, Noto D, Sano S, Tomizawa Y, Yokoyama K, Hattori N, Miyake S. Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder. J Neuroinflammation. 2022 Jan 6;19(1):6. Kato S, Hagiwara A, Yokoyama K, Andica C, Tomizawa Y, Hoshino Y, Uchida W, Nishimura Y, Fujita S, Kamagata K, Hori M, Hattori N, Abe O, Aoki S. Microstructural white matter abnormalities in multiple sclerosis and neuromyelitis optica spectrum disorders: Evaluation by advanced diffusion imaging. J Neurol Sci. 2022 Feb 24;436:120205. Andica C, Hagiwara A, Yokoyama K, Kato S, Uchida W, Nishimura Y, Fujita S, Kamagata K, Hori M, Tomizawa Y, Hattori N, Aoki S. Multimodal magnetic resonance imaging quantification of gray matter alterations in relapsing-remitting multiple sclerosis and neuromyelitis optica spectrum disorder. J Neurosci Res. 2022 Mar 22. Fujita S, Hagiwara A, Takei N, Hwang KP, Fukunaga I, Kato S, Andica C, Kamagata K, Yokoyama K, Hattori N, Abe O, Aoki S. Accelerated Isotropic Multiparametric Imaging by High Spatial Resolution 3D-QALAS With Compressed Sensing: A Phantom, Volunteer, and Patient Study. Invest Radiol. 2021 May 1;56(5):292-300. Fujita S, Yokoyama K, Hagiwara A, Kato S, Andica C, Kamagata K, Hattori N, A be O, Aoki S. 3D Quantitative Synthetic MRI in the Evaluation of Multiple Sclerosis Lesions. AJNR Am J Neuroradiol. 2021 Mar;42(3):471-478. Cossu D, ＊Yokoyama K, Sakanishi T, Kuwahara-Arai K, Momotani E, Hattori N. A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE. J Neuroimmunol. 2021 Mar 15;352:577477. Hagiwara A, Otsuka Y, Andica C, Kato S, Yokoyama K, Hori M, Fujita S, Kamagata K, Hattori N, Aoki S. Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorders by multiparametric quantitative MRI using convolutional neural network. J Clin Neurosci. 2021 May;87:55-58. Maekawa T, Hagiwara A, Yokoyama K, Hori M, Andica C, Fujita S, Kamagata K, Wada A, Abe O, Tomizawa Y, Hattori N, Aoki S. Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics. Neuroradiology. 2022 Mar;64(3):465-471. Cossu D, Yokoyama K, Sechi LA, Hattori N. Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study. Front Immunol. 2021 Aug 4;12:681386. Cossu D, Yokoyama K, Sato S, Noda S, Sechi LA, Hattori N. PARKIN modifies peripheral immune response and increases neuroinflammation in active experimental autoimmune encephalomyelitis (EAE). J Neuroimmunol. 2021 Oct 15;359:577694. Hayashi F, Isobe N, Cossu D, Yokoyama K, Sakoda A, Matsushita T, Hattori N, Kira JI. Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis. J Neuroimmunol. 2021 Nov 15;360:577701. Sano M, Iseki T, Sasaki M, Tsukune Y, Yasuda H, Kanazawa K, Arakawa A, Yokoyama K, Komatsu N, Hattori N, Nishioka K. Improvement in the Symptoms and VEGF Levels after Resection of an Extrame Dullary Spinal Tumor and Additional Chemotherapy in a Patient with Multiple Myeloma Complicated with POEMS Syndrome. Intern Med. 2021;60(22):3625-3630. Daida K, Nishioka K, Takanashi M, Kobayashi M, Yoshikawa K, Kusunoki S, Yokoyama K, Hattori N. New-onset Refractory Status Epilepticus Involving the Limbic System, Spinal Cord, and Peripheral Nerves. Intern Med. 2020 Jan 15;59(2):267-270. IF:1.271, Hagiwara A, Kamagata K, Shimoji K, Yokoyama K, Andica C, Hori M, Fujita S, Maekawa T, Irie R, Akashi T, Wada A, Suzuki M, Abe O, Hattori N, Aoki S. White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging. AJNR Am J Neuroradiol. 2019 Oct;40(10):1642-1648. Kamagata K, Zalesky A, Yokoyama K, Andica C, Hagiwara A, Shimoji K, Kumamaru KK, Takemura MY, Hoshino Y, Kamiya K, Hori M, Pantelis C, Hattori N, Aoki S. MR g-ratio-weighted connectome analysis in patients with multiple sclerosis. Sci Rep. 2019 Sep 18;9(1):13522. Daida K, Ogaki K, Hayashida A, Ando M, Yokoyama K, Noda K, Kanbayashi T, Hattori N, Okuma Y. Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder. Intern Med. 2020 Feb 15;59(4):577-579. Shimada T, Hoshino Y, Tsunemi T, Hattori A, Nakagawa E, Yokoyama K, Hattori N. Neuromyelitis optica spectrum disorder after treatment with pembrolizumab. Mult Scler Relat Disord. 2020 Jan;37:101447. Tachibana Y, Hagiwara A, Hori M, Kershaw J, Nakazawa M, Omatsu T, Kishimoto R, Yokoyama K, Hattori N, Aoki S, Higashi T, Obata T. The Utility of a Convolutional Neural Network for Generating a Myelin Volume Index Map from Rapid Simultaneous Relaxometry Imaging. Magn Reson Med Sci. 2020 Dec 1;19(4):324-332. Saccenti L, Hagiwara A, Andica C, Yokoyama K, Fujita S, Kato S, Maekawa T, Kamagata K, Le Berre A, Hori M, Wada A, Tateishi U, Hattori N, Aoki S. Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis. Cells. 2020 Feb 8;9(2):393. Oyama M, Okada K, Masuda M, Shimizu Y, Yokoyama K, Uzawa A, Kawaguchi N,Ikeguchi R, Hoshino Y, Hatano T, Ozawa Y, Nakahara J, Aizawa H, Kitagawa K, Hattori N, Kuwabara S, Murai H, Suzuki S. Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis. Ther Adv Neurol Disord. 2020 Mar 18;13:1756286420904207. Hagiwara A, Otsuka Y, Hori M, Tachibana Y, Yokoyama K, Fujita S, Andica C, Kamagata K, Irie R, Koshino S, Maekawa T, Chougar L, Wada A, Takemura MY, Hattori N, Aoki S. Improving the Quality of Synthetic FLAIR Images with Deep Learning Using a Conditional Generative Adversarial Network for Pixel-by-Pixel Image Translation. AJNR Am J Neuroradiol. 2019 Feb;40(2):224-230. Cossu D, ＊Yokoyama K, Sakanishi T, Momotani E, Hattori N. Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis. J Neuroimmunol. 2019 May 15;330:174-177. Kamo H, Ueno Y, Sugiyama M, Miyamoto N, Yamashiro K, Tanaka R, Yokoyama K, Hattori N. Pontine hemorrhage accompanied by neuromyelitis optica spectrum disorder. J Neuroimmunol. 2019 May 15;330:19-22. Cossu D, Yokoyama K, Nobutaka N, Sechi LA. From Sardinia to Japan: update on the role of MAP in multiple sclerosis. Future Microbiol. 2019 May;14:643-646. Andica C, Hagiwara A, Kamagata K, Yokoyama K, Shimoji K, Saito A, Takenaka Y, Nakazawa M, Hori M, Cohen-Adad J, Takemura MY, Hattori N, Aoki S. Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging. Sci Rep. 2019 May 31;9(1):8147. Saccenti L, Andica C, Hagiwara A, Yokoyama K, Takemura MY, Fujita S, Maekawa T, Kamagata K, Le Berre A, Hori M, Hattori N, Aoki S. Brain tissue and myelin volumetric analysis in multiple sclerosis at 3T MRI with various in-plane resolutions using synthetic MRI. Neuroradiology. 2019 Nov;61(11):1219-1227. Nishida Y, Takahashi YK, Kanai T, Nose Y, Ishibashi S, Sanjo N, Uzawa A, Oda F, Ozawa Y, Kuwabara S, Noguchi E, Suzuki S, Nakahara J, Suzuki N, Ogawa T, Yokoyama K, Hattori N, Konno S, Fujioka T, Kawaguchi N, Hatanaka Y, Sonoo M, Kaneko J, Ogino M, Nishiyama K, Nomura K, Yokota T. Safety of tapering tacrolimus dose in patients with well-controlled anti-acetylcholine receptor antibody-positive myasthenia gravis. Eur J Neurol. 2020 Jan;27(1):100-104. Kamo H, Hatano T, Kanai K, Aoki N, Kamiyama D, Yokoyama K, Takanashi M, Yamashita Y, Shimo Y, Hattori N. Pembrolizumab-related systemic myositis involving ocular and hindneck muscles resembling myasthenic gravis: a case report. BMC Neurol. 2019 Aug 5;19(1):184. Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N. Clinical Characterization of Definite Autoimmune Limbic Encephalitis: A 30-case Series. Intern Med. 2019 Dec 1;58(23):3369-3378. Yokoyama K, Cossu D, Hoshino Y, Tomizawa Y, Momotani E, Hattori N. Anti-Mycobacterial Antibodies in Paired Cerebrospinal Fluid and Serum Samples from Japanese Patients with Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder. J Clin Med. Dec 7;7(12).2018 Hirano M, Jimbo K, Ogawa M, Ochi K, Makiyama J, Kawamata T, Yokoyama K, Tanaka T, Inamoto Y, Yamano Y, Fukuda T, Uchimaru K, Imai Y, Tojo A. Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation. Bone Marrow Transplant. 2018 Nov;53(11):1470-1473.2018. Nakazato T, Tsuji Y, Kanai K, Noto YI, Hoshino Y, Yamashiro K, Yokoyama K, Nishioka K, Shimo Y, Watanabe O, Mizuno T, Hattori N. Isaacs syndrome: A slow potassium channelopathy caused by autoantibodies? Clin Neurophysiol.May;129(5):956-958.2018. van Schaik IN, Bril V, van Geloven N, Hartung HP, Lewis RA, Sobue G, Lawo JP, Praus M, Mielke O, Durn BL, Cornblath DR, Merkies ISJ; PATH study group. Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurol. 2018 Jan;17(1):35-46. 2018. Cossu D, Yokoyama K, Hattori N. Bacteria-Host Interactions in Multiple Sclerosis. Front Microbiol. 2018 Dec 4;9:2966. 2018.　Review. Cossu D, Yokoyama K, Tomizawa Y, Momotani E, Hattori N. Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system. Sci Rep, 7(1):3179, 2017. Kanai T, Uzawa A, Sato Y, Suzuki S, Kawaguchi N, Himuro K, Oda F, Ozawa Y, Nakahara J, Suzuki N, Takahashi YK, Ishibashi S, Yokota T, Ogawa T, Yokoyama K, Hattori N, Izaki S, Oji S. Nomura K, Kaneko J, Nishiyama K, Yoshino I, Kuwabara S. A clinical predictive score for postoperative myasthenic crisis. Ann Neurol. 2017, 82:841-849. Takemura MY, Hori M, Yokoyama K, Hamasaki N, Suzuki M, Kamagata K, Kamiya K, Suzuki Y, Kyogoku S, Masutani Y, Hattori N, Aoki S. Alterations of the optic pathway between unilateral and bilateral optic nerve damage in multiple sclerosis as revealed by the combined use of advanced diffusion kurtosis imaging and visual evoked potentials, Magn Reson Imaging. 2017, 39:24-30. Hagiwara A, Hori M, Yokoyama K, Nakazawa M, Ueda R, Horita M, Andica C, Abe O, Aoki S. Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio, AJNR Am J Neuroradiol. 2017, 38(10):1934-1940. Hagiwara A, Hori M, Yokoyama K, Takemura MY, Andica C, Tabata T, Kamagata K, Suzuki M, Kumamaru KK, Nakazawa M, Takano N, Kawasaki H, Hamasaki N, Kunimatsu A, Aoki S. Synthetic MRI in the Detection of Multiple Sclerosis Plaques. AJNR Am J Neuroradiol. 2017, 38(2):257-263. Hagiwara A, Hori M, Yokoyama K, Takemura MY, Andica C, Kumamaru KK, Nakazawa M, Takano N, Kawasaki H, Sato S, Hamasaki N, Kunimatsu A, Aoki S. Utility of a Multiparametric Quantitative MRI Model That Assesses Myelin and Edema for Evaluating Plaques, Periplaque White Matter, and Normal-Appearing White Matter in Patients with Multiple Sclerosis: A Feasibility Study. AJNR Am J Neuroradiol. 2017, 38(2):237-242. 総説 Cossu D, Yokoyama K, Hattori N. Conflicting Role of Mycobacterium Species in Multiple Sclerosis. Front. Neurol, 8:216, May, 2017. Review Yokoyama K, Hattori N. Management of myasthenia gravis in daily practice for general neurologists and healthcare professionals, Clinical and Experimental Neuroimmunology 8:162–170, 2017 Okuzumi A, Hatano T, Nakahara T, Yokoyama K, Hattori N.　Ophthalmic nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy.　Neurology. 2014 Apr 29;82(17):1566-7. Hori M, Yoshida M, Yokoyama K, Kamagata K, Kumagai F, Fukunaga I, Kamiya K, Suzuki M, Masutani Y, Hamasaki N, Suzuki Y, Kyogoku S, Hattori N, Aoki S.　Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter.　 Magn Reson Imaging. 2014 Jul;32(6):625-9. Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamoto T, Murata M, Toda T, Miyake S, Yamamura T.　Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica.　PLoS One. 2013 Dec 10;8(12):e83036. Yoshida M, Hori M, Yokoyama K, Fukunaga I, Suzuki M, Kamagata K, Shimoji K, Nakanishi A, Hattori N, Masutani Y, Aoki S.　Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience.Jpn J Radiol. 2013 Jan;31(1):50-5. Fukae J, Kawanabe T, Akao N, Kado M, Tokoro M, Yokoyama K, Hattori N. Longitudinal myelitis caused by visceral larva migrans associated with Toxocara cati infection: case report. Clin Neurol Neurosurg. 2012 Sep;114(7):1091-4. Saida T, Itoyama Y, Tashiro K, Kira J, Hao Q, (Yokoyama K): Interferon Beta-1a Multiple Sclerosis Study Group of Japan．Intramuscular interferon beta-1a is effective in Japanese patients with relapsing-remitting multiple sclerosis: a pre-treatment versus treatment comparison study of gadolinium-enhanced MRI brain lesions, Mult Scler. 2012 Dec;18(12):1782-90. Sato DK, Nakashima I, Fukazawa T, Shimizu Y, Tomizawa Y, Yokoyama K, Misu T, Creeke PI, Farrell R, Giovannoni G, Itoyama Y, Fujihara K, Aoki M．Neutralizing antibodies are associated with a reduction of interferon-β efficacy during the treatment of Japanese multiple sclerosis patients, Tohoku J Exp Med. 2012;228(2):85-92. Tomizawa Y, Yokoyama K, Saiki S, Takahashi T, Matsuoka J, Hattori N. Blood-Brain Barrier Disruption is More Severe in Neuromyelitis Optica than in Multiple Sclerosis and Correlates with Clinical Disability. J Int Med Res. 2012;40(4):1483-91. Hatano T, Shimada Y, Kono A, Kubo S, Yokoyama K, Yoritaka A, Nakahara T, Takahashi Y, Hattori N: Atypical Miller Fisher syndrome associated with glutamate receptor antibodies. BMJ Case Rep, 2011 Shimizu Y, Fujihara K, Kubo S, Takahashi T, Misu T, Nakashima I, Yokoyama K, Itoyama Y, Uchiyama S. Therapeutic efficacy of interferon β-1b in Japanese patients with optic-spinal multiple sclerosis. Tohoku J Exp Med. 2011;223(3):211-4. Suzuki S, Utsugisawa K, Yoshikawa H, Motomura M, Matsubara S, Yokoyama K, Nagane Y, Maruta T, Satoh T, Sato H, Kuwana M, Suzuki N. Autoimmune targets of heart and skeletal muscles in myasthenia gravis. Arch Neurol. 2009 Nov;66(11):1334-8. Satoh J, Nakanishi M, Koike F, Onoue H, Aranami T, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Saito T, Ohta M, Miyake S, Kanda T, Fukazawa T, Yamamura T.　T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patient J Neuroimmunol. 2006 May;174(1-2):108-18. Satoh J, Nakanishi M, Koike F, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T. Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Neurobiol Dis. 2005 Apr;18(3):537-50. Koike F, Satoh J, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T.　Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis. J Neuroimmunol. 2003 Jun;139(1-2):109-18. Kawamura K, Yamamura T, Yokoyama K, Chui DH, Fukui Y, Sasazuki T, Inoko H, David CS, Tabira T. Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. J Clin Invest. 2000 Apr;105(7):977-84. Yamamura T, Geng TC, Kozovska MF, Yokoyama K, Cohen IR, Tabira T. An alpha-chain TCR CDR3 peptide can enhance EAE induced by myelin basic protein or proteolipid protein. J Neurosci Res. 1996 Sep 15;45(6):706-13. 著書横山和正　今日の治療指針　2022　急性散在性脳脊髄炎　医学書院　974-975、2022 横山和正、服部信孝．コロナ禍での実臨床における多発性硬化症診療、医学と薬学　自然科学社　2022(4):481-492、2022 横山和正、服部信孝脳神経内科診断ハンドブック　サルコイドーシスによる神経・筋障害中外医学書266-272,2022 横山和正、服部信孝．CD20抗体　オファツムマブ(解説/特集)、Clinical Neuroscience 39:1499-1504, 2021 横山和正、服部信孝．【多発性硬化症と視神経脊髄炎update-基礎・臨床研究の最新知見-】脱髄性疾患の治療update　中枢神経脱髄性疾患の対症療法と生活指導・患者説明(解説/特集)、日本臨床 79:1638-1649, 2021 横山和正、服部信孝．【多発性硬化症治療の現状】多発性硬化症治療薬と感染症、脳神経内科　90:445-453, 2019 下畑享良、久保真人、饗場郁子、服部信孝、吉田一人、海野佳子、横山和正、小川崇、加世田ゆみ子、小池亮子、清水優子、坪井義夫、道勇学、三澤園子、宮地隆史、戸田達史、武田篤、日本神経学会キャリア形成促進委員会小川崇、横山和正、服部信孝. 【燃え尽き症候群】燃え尽き症候群とは何か(解説/特集)、脳神経内科　94:230-235, 2021 横山和正、服部信孝．【多発性硬化症治療の現状】多発性硬化症治療薬と感染症(解説/特集)、脳神経内科　90:445-453, 2019 横山和正、服部信孝．【診療力を上げる!　症例問題集】(第7章)神経・筋　症例問題　急性発症の統合失調様精神症状を呈した女性(解説/特集)、内科 123:899-901, 2019 横山和正、小川崇、服部信孝．医師のバーンアウト(燃え尽き症候群)をふせぐためには?　脳神経内科領域の取組みから学ぶ　大学における燃え尽き症候群の課題と対策(解説)、医学のあゆみ 268:1017-1020, 2019 横山和正、服部信孝．【診療力を上げる!　症例問題集】(第7章)神経・筋　症例問題　急性発症の統合失調様精神症状を呈した女性(解説/特集)、内科 123:899-901, 2019 解説/特集横山和正(順天堂大学医学部脳神経内科), 佐藤竜介, 牧岡大器, 飯塚幸彦, 長谷昌知, Yan Ling, 鳥居慎一, 齋田孝彦背景因子別にみたナタリズマブの日本人多発性硬化症に対する有効性　ナタリズマブ使用成績調査中間解析から(第二報)(原著論文) 診療と新薬 (0037-380X)55巻6号 Page449-456(2018.06) 横山和正(順天堂大学医学部脳神経内科学講座), 服部信孝【痛み関連の神経内科疾患】多発性硬化症の痛みの病態とマネージメント(解説/特集) ペインクリニック (0388-4171)39巻9号 Page1169-1178(2018.09) 藤田翔平(順天堂大学医学部放射線診断学講座), 堀正明, 萩原彰文, 前川朋子, アンディカ・クリスティナ , 入江隆介, 鎌形康司, 神谷昂平, 横山和正, 青木茂樹【Step up MRI 2018　MRI新技術　基礎から臨床への橋渡し】MRIの新技術　臨床編　頭部領域におけるMRIの新技術と臨床応用　OGSE-DWIとsynthetic MRIを中心に(解説/特集) INNERVISION (0913-8919)33巻9号 Page45-48(2018.08) 横山和正(順天堂大学医学部脳神経内科), 服部信孝【パーキンソン病(第2版)-基礎・臨床研究のアップデート-】検査・診断　関連疾患　脳炎後パーキンソニズム(解説/特集) 日本臨床 (0047-1852)76巻増刊4 パーキンソン病 Page388-395(2018.05) 【神経内科検査のみかた-脳のイメージングを中心に】どんなイメージがあるの?　神経疾患と抗体 Author：横山和正(順天堂大学医学部神経学講座) Source：Modern Physician(0913-7963)33巻5号 Page615-620(2013.05) 富沢雄二, 横山和正, 服部信孝.【NMO spectrumとAQP4の病態意義】 Tumefactive MSとNMO spectrum disorderのextensive brain lesion(解説/特集). 神経内科 76(6):549-553, 2012年6月富沢雄二, 横山和正, 服部信孝.【内科疾患と脳神経疾患:診断と治療の進歩】膠原病と脳神経疾患(解説/特集). 日本内科学会雑誌 101(8):2242-2248, 2012年8月横山和正．患者への説明のポイント　－　多発性硬化症（MS）診療のすべて、フィンゴリモド（FTY720）、編者　山村隆、診断と治療社、2012年横山和正．最新アプローチ　多発性硬化症と視神経脊髄炎、専門編集　吉良潤一、中山書店、2012年　清水優子, 藤原一男, 久保幸子, 三須建郎, 富澤雄二, 横山和正, 高橋利幸, 服部信孝, 糸山泰人, 内山真一郎. 多発性硬化症と視神経脊髄炎における髄液ミエリン塩基性蛋白(MBP). 医学と薬学. 巻2号 Page281-286(2010.08) 横山和正. 【医師不足時代の神経内科医療の在り方　都市と地方での医療デバイド】大都市医学部附属病院からみた神経内科不足の現状分析とその対策. 神経内科. 巻4号 Page374-379(2010.10) 横山和正.シリーズ　難治性疾患の今　～臨床のピットフォール～　第6回　重症筋無力症Medical tribune 2010年9月9日発行号（VOL 43，No.36）Ｐ５０横山和正. 【膠原病と神経疾患　基礎から臨床まで】　神経膠原病各論　神経内科医から、膠原病科医から関節リウマチ　神経内科から　神経診断入門. Clinical Neuroscience. 巻2号 Page175-180(2010.02) 横山和正【免疫性神経疾患　新たな治療戦略に向けて】治療の実際　作用機序と適応・効果・副作用　ステロイド. 内科. 巻5号 Page816-823(2010.05) 横山和正. 【眼球運動の生理と病態】各種疾患での眼球運動障害　多発性硬化症. Clinical Neuroscience. 巻1号 Page88-91(2010.01)

研究テーマ

神経免疫疾患

研究業績（論文）

Cossu D, Ruberto S, Yokoyama K, Hattori N, Sechi LA. Efficacy of BCG vaccine in animal models of neurological disorders. Vaccine. 2022 Jan 24;40(3):432-436.
Hoshino Y, Noto D, Sano S, Tomizawa Y, Yokoyama K, Hattori N, Miyake S. Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder. J Neuroinflammation. 2022 Jan 6;19(1):6.
Kato S, Hagiwara A, Yokoyama K, Andica C, Tomizawa Y, Hoshino Y, Uchida W, Nishimura Y, Fujita S, Kamagata K, Hori M, Hattori N, Abe O, Aoki S. Microstructural white matter abnormalities in multiple sclerosis and neuromyelitis optica spectrum disorders: Evaluation by advanced diffusion imaging. J Neurol Sci. 2022 Feb 24;436:120205.
Andica C, Hagiwara A, Yokoyama K, Kato S, Uchida W, Nishimura Y, Fujita S, Kamagata K, Hori M, Tomizawa Y, Hattori N, Aoki S. Multimodal magnetic resonance imaging quantification of gray matter alterations in relapsing-remitting multiple sclerosis and neuromyelitis optica spectrum disorder. J Neurosci Res. 2022 Mar 22.
Fujita S, Hagiwara A, Takei N, Hwang KP, Fukunaga I, Kato S, Andica C, Kamagata K, Yokoyama K, Hattori N, Abe O, Aoki S. Accelerated Isotropic Multiparametric Imaging by High Spatial Resolution 3D-QALAS With Compressed Sensing: A Phantom, Volunteer, and Patient Study. Invest Radiol. 2021 May 1;56(5):292-300.
Fujita S, Yokoyama K, Hagiwara A, Kato S, Andica C, Kamagata K, Hattori N, A be O, Aoki S. 3D Quantitative Synthetic MRI in the Evaluation of Multiple Sclerosis Lesions. AJNR Am J Neuroradiol. 2021 Mar;42(3):471-478.
Cossu D, ＊Yokoyama K, Sakanishi T, Kuwahara-Arai K, Momotani E, Hattori N. A mucosal immune response induced by oral administration of heat-killed Mycobacterium avium subsp. paratuberculosis exacerbates EAE. J Neuroimmunol. 2021 Mar 15;352:577477.
Hagiwara A, Otsuka Y, Andica C, Kato S, Yokoyama K, Hori M, Fujita S, Kamagata K, Hattori N, Aoki S. Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorders by multiparametric quantitative MRI using convolutional neural network. J Clin Neurosci. 2021 May;87:55-58.
Maekawa T, Hagiwara A, Yokoyama K, Hori M, Andica C, Fujita S, Kamagata K, Wada A, Abe O, Tomizawa Y, Hattori N, Aoki S. Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics. Neuroradiology. 2022 Mar;64(3):465-471.
Cossu D, Yokoyama K, Sechi LA, Hattori N. Potential of PINK1 and PARKIN Proteins as Biomarkers for Active Multiple Sclerosis: A Japanese Cohort Study. Front Immunol. 2021 Aug 4;12:681386.
Cossu D, Yokoyama K, Sato S, Noda S, Sechi LA, Hattori N. PARKIN modifies peripheral immune response and increases neuroinflammation in active experimental autoimmune encephalomyelitis (EAE). J Neuroimmunol. 2021 Oct 15;359:577694.
Hayashi F, Isobe N, Cossu D, Yokoyama K, Sakoda A, Matsushita T, Hattori N, Kira JI. Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis. J Neuroimmunol. 2021 Nov 15;360:577701.
Sano M, Iseki T, Sasaki M, Tsukune Y, Yasuda H, Kanazawa K, Arakawa A, Yokoyama K, Komatsu N, Hattori N, Nishioka K. Improvement in the Symptoms and VEGF Levels after Resection of an Extrame Dullary Spinal Tumor and Additional Chemotherapy in a Patient with Multiple Myeloma Complicated with POEMS Syndrome. Intern Med. 2021;60(22):3625-3630.
Daida K, Nishioka K, Takanashi M, Kobayashi M, Yoshikawa K, Kusunoki S, Yokoyama K, Hattori N. New-onset Refractory Status Epilepticus Involving the Limbic System, Spinal Cord, and Peripheral Nerves. Intern Med. 2020 Jan 15;59(2):267-270. IF:1.271,
Hagiwara A, Kamagata K, Shimoji K, Yokoyama K, Andica C, Hori M, Fujita S, Maekawa T, Irie R, Akashi T, Wada A, Suzuki M, Abe O, Hattori N, Aoki S. White Matter Abnormalities in Multiple Sclerosis Evaluated by Quantitative Synthetic MRI, Diffusion Tensor Imaging, and Neurite Orientation Dispersion and Density Imaging. AJNR Am J Neuroradiol. 2019 Oct;40(10):1642-1648.
Kamagata K, Zalesky A, Yokoyama K, Andica C, Hagiwara A, Shimoji K, Kumamaru KK, Takemura MY, Hoshino Y, Kamiya K, Hori M, Pantelis C, Hattori N, Aoki S. MR g-ratio-weighted connectome analysis in patients with multiple sclerosis. Sci Rep. 2019 Sep 18;9(1):13522.
Daida K, Ogaki K, Hayashida A, Ando M, Yokoyama K, Noda K, Kanbayashi T, Hattori N, Okuma Y. Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder. Intern Med. 2020 Feb 15;59(4):577-579.
Shimada T, Hoshino Y, Tsunemi T, Hattori A, Nakagawa E, Yokoyama K, Hattori N. Neuromyelitis optica spectrum disorder after treatment with pembrolizumab. Mult Scler Relat Disord. 2020 Jan;37:101447.
Tachibana Y, Hagiwara A, Hori M, Kershaw J, Nakazawa M, Omatsu T, Kishimoto R, Yokoyama K, Hattori N, Aoki S, Higashi T, Obata T. The Utility of a Convolutional Neural Network for Generating a Myelin Volume Index Map from Rapid Simultaneous Relaxometry Imaging. Magn Reson Med Sci. 2020 Dec 1;19(4):324-332.
Saccenti L, Hagiwara A, Andica C, Yokoyama K, Fujita S, Kato S, Maekawa T, Kamagata K, Le Berre A, Hori M, Wada A, Tateishi U, Hattori N, Aoki S. Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis. Cells. 2020 Feb 8;9(2):393.
Oyama M, Okada K, Masuda M, Shimizu Y, Yokoyama K, Uzawa A, Kawaguchi N,Ikeguchi R, Hoshino Y, Hatano T, Ozawa Y, Nakahara J, Aizawa H, Kitagawa K, Hattori N, Kuwabara S, Murai H, Suzuki S. Suitable indications of eculizumab for patients with refractory generalized myasthenia gravis. Ther Adv Neurol Disord. 2020 Mar 18;13:1756286420904207.
Hagiwara A, Otsuka Y, Hori M, Tachibana Y, Yokoyama K, Fujita S, Andica C, Kamagata K, Irie R, Koshino S, Maekawa T, Chougar L, Wada A, Takemura MY, Hattori N, Aoki S. Improving the Quality of Synthetic FLAIR Images with Deep Learning Using a Conditional Generative Adversarial Network for Pixel-by-Pixel Image Translation. AJNR Am J Neuroradiol. 2019 Feb;40(2):224-230.
Cossu D, ＊Yokoyama K, Sakanishi T, Momotani E, Hattori N. Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis. J Neuroimmunol. 2019 May 15;330:174-177.
Kamo H, Ueno Y, Sugiyama M, Miyamoto N, Yamashiro K, Tanaka R, Yokoyama K, Hattori N. Pontine hemorrhage accompanied by neuromyelitis optica spectrum disorder. J Neuroimmunol. 2019 May 15;330:19-22.
Cossu D, Yokoyama K, Nobutaka N, Sechi LA. From Sardinia to Japan: update on the role of MAP in multiple sclerosis. Future Microbiol. 2019 May;14:643-646.
Andica C, Hagiwara A, Kamagata K, Yokoyama K, Shimoji K, Saito A, Takenaka Y, Nakazawa M, Hori M, Cohen-Adad J, Takemura MY, Hattori N, Aoki S. Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging. Sci Rep. 2019 May 31;9(1):8147.
Saccenti L, Andica C, Hagiwara A, Yokoyama K, Takemura MY, Fujita S, Maekawa T, Kamagata K, Le Berre A, Hori M, Hattori N, Aoki S. Brain tissue and myelin volumetric analysis in multiple sclerosis at 3T MRI with various in-plane resolutions using synthetic MRI. Neuroradiology. 2019 Nov;61(11):1219-1227.
Nishida Y, Takahashi YK, Kanai T, Nose Y, Ishibashi S, Sanjo N, Uzawa A, Oda F, Ozawa Y, Kuwabara S, Noguchi E, Suzuki S, Nakahara J, Suzuki N, Ogawa T, Yokoyama K, Hattori N, Konno S, Fujioka T, Kawaguchi N, Hatanaka Y, Sonoo M, Kaneko J, Ogino M, Nishiyama K, Nomura K, Yokota T. Safety of tapering tacrolimus dose in patients with well-controlled anti-acetylcholine receptor antibody-positive myasthenia gravis. Eur J Neurol. 2020 Jan;27(1):100-104.
Kamo H, Hatano T, Kanai K, Aoki N, Kamiyama D, Yokoyama K, Takanashi M, Yamashita Y, Shimo Y, Hattori N. Pembrolizumab-related systemic myositis involving ocular and hindneck muscles resembling myasthenic gravis: a case report. BMC Neurol. 2019 Aug 5;19(1):184.
Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N. Clinical Characterization of Definite Autoimmune Limbic Encephalitis: A 30-case Series. Intern Med. 2019 Dec 1;58(23):3369-3378.
Yokoyama K, Cossu D, Hoshino Y, Tomizawa Y, Momotani E, Hattori N.
Anti-Mycobacterial Antibodies in Paired Cerebrospinal Fluid and Serum Samples from Japanese Patients with Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder.
J Clin Med. Dec 7;7(12).2018
Hirano M, Jimbo K, Ogawa M, Ochi K, Makiyama J, Kawamata T, Yokoyama K, Tanaka T, Inamoto Y, Yamano Y, Fukuda T, Uchimaru K, Imai Y, Tojo A.
Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation.
Bone Marrow Transplant. 2018 Nov;53(11):1470-1473.2018.
Nakazato T, Tsuji Y, Kanai K, Noto YI, Hoshino Y, Yamashiro K, Yokoyama K, Nishioka K, Shimo Y, Watanabe O, Mizuno T, Hattori N.
Isaacs syndrome: A slow potassium channelopathy caused by autoantibodies?
Clin Neurophysiol.May;129(5):956-958.2018.
van Schaik IN, Bril V, van Geloven N, Hartung HP, Lewis RA, Sobue G, Lawo JP, Praus M, Mielke O, Durn BL, Cornblath DR, Merkies ISJ; PATH study group.
Subcutaneous immunoglobulin for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (PATH): a randomised, double-blind, placebo-controlled, phase 3 trial.
Lancet Neurol. 2018 Jan;17(1):35-46. 2018.
Cossu D, Yokoyama K, Hattori N.
Bacteria-Host Interactions in Multiple Sclerosis.
Front Microbiol. 2018 Dec 4;9:2966. 2018.　Review.
Cossu D, Yokoyama K, Tomizawa Y, Momotani E, Hattori N. Altered humoral immunity to mycobacterial antigens in Japanese patients affected by inflammatory demyelinating diseases of the central nervous system. Sci Rep, 7(1):3179, 2017.
Kanai T, Uzawa A, Sato Y, Suzuki S, Kawaguchi N, Himuro K, Oda F, Ozawa Y, Nakahara J, Suzuki N, Takahashi YK, Ishibashi S, Yokota T, Ogawa T, Yokoyama K, Hattori N, Izaki S, Oji S. Nomura K, Kaneko J, Nishiyama K, Yoshino I, Kuwabara S. A clinical predictive score for postoperative myasthenic crisis. Ann Neurol. 2017, 82:841-849.
Takemura MY, Hori M, Yokoyama K, Hamasaki N, Suzuki M, Kamagata K, Kamiya K, Suzuki Y, Kyogoku S, Masutani Y, Hattori N, Aoki S. Alterations of the optic pathway between unilateral and bilateral optic nerve damage in multiple sclerosis as revealed by the combined use of advanced diffusion kurtosis imaging and visual evoked potentials, Magn Reson Imaging. 2017, 39:24-30.
Hagiwara A, Hori M, Yokoyama K, Nakazawa M, Ueda R, Horita M, Andica C, Abe O, Aoki S. Analysis of White Matter Damage in Patients with Multiple Sclerosis via a Novel In Vivo MR Method for Measuring Myelin, Axons, and G-Ratio, AJNR Am J Neuroradiol. 2017, 38(10):1934-1940.
Hagiwara A, Hori M, Yokoyama K, Takemura MY, Andica C, Tabata T, Kamagata K, Suzuki M, Kumamaru KK, Nakazawa M, Takano N, Kawasaki H, Hamasaki N, Kunimatsu A, Aoki S. Synthetic MRI in the Detection of Multiple Sclerosis Plaques. AJNR Am J Neuroradiol. 2017, 38(2):257-263.
Hagiwara A, Hori M, Yokoyama K, Takemura MY, Andica C, Kumamaru KK, Nakazawa M, Takano N, Kawasaki H, Sato S, Hamasaki N, Kunimatsu A, Aoki S. Utility of a Multiparametric Quantitative MRI Model That Assesses Myelin and Edema for Evaluating Plaques, Periplaque White Matter, and Normal-Appearing White Matter in Patients with Multiple Sclerosis: A Feasibility Study. AJNR Am J Neuroradiol. 2017, 38(2):237-242.
総説
Cossu D, Yokoyama K, Hattori N. Conflicting Role of Mycobacterium Species in Multiple Sclerosis. Front. Neurol, 8:216, May, 2017. Review
Yokoyama K, Hattori N. Management of myasthenia gravis in daily practice for general neurologists and healthcare professionals, Clinical and Experimental Neuroimmunology 8:162–170, 2017
Okuzumi A, Hatano T, Nakahara T, Yokoyama K, Hattori N.　Ophthalmic nerve hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy.　Neurology. 2014 Apr 29;82(17):1566-7.
Hori M, Yoshida M, Yokoyama K, Kamagata K, Kumagai F, Fukunaga I, Kamiya K, Suzuki M, Masutani Y, Hamasaki N, Suzuki Y, Kyogoku S, Hattori N, Aoki S.　Multiple sclerosis: Benefits of q-space imaging in evaluation of normal-appearing and periplaque white matter.　 Magn Reson Imaging. 2014 Jul;32(6):625-9.
Chihara N, Aranami T, Oki S, Matsuoka T, Nakamura M, Kishida H, Yokoyama K, Kuroiwa Y, Hattori N, Okamoto T, Murata M, Toda T, Miyake S, Yamamura T.　Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica.　PLoS One. 2013 Dec 10;8(12):e83036.
Yoshida M, Hori M, Yokoyama K, Fukunaga I, Suzuki M, Kamagata K, Shimoji K, Nakanishi A, Hattori N, Masutani Y, Aoki S.　Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience.Jpn J Radiol. 2013 Jan;31(1):50-5.
Fukae J, Kawanabe T, Akao N, Kado M, Tokoro M, Yokoyama K, Hattori N. Longitudinal myelitis caused by visceral larva migrans associated with Toxocara cati infection: case report. Clin Neurol Neurosurg. 2012 Sep;114(7):1091-4.
Saida T, Itoyama Y, Tashiro K, Kira J, Hao Q, (Yokoyama K): Interferon Beta-1a Multiple Sclerosis Study Group of Japan．Intramuscular interferon beta-1a is effective in Japanese patients with relapsing-remitting multiple sclerosis: a pre-treatment versus treatment comparison study of gadolinium-enhanced MRI brain lesions, Mult Scler. 2012 Dec;18(12):1782-90.

Sato DK, Nakashima I, Fukazawa T, Shimizu Y, Tomizawa Y, Yokoyama K, Misu T, Creeke PI, Farrell R, Giovannoni G, Itoyama Y, Fujihara K, Aoki M．Neutralizing antibodies are associated with a reduction of interferon-β efficacy during the treatment of Japanese multiple sclerosis patients, Tohoku J Exp Med. 2012;228(2):85-92.

Tomizawa Y, Yokoyama K, Saiki S, Takahashi T, Matsuoka J, Hattori N. Blood-Brain Barrier Disruption is More Severe in Neuromyelitis Optica than in Multiple Sclerosis and Correlates with Clinical Disability. J Int Med Res. 2012;40(4):1483-91.

Hatano T, Shimada Y, Kono A, Kubo S, Yokoyama K, Yoritaka A, Nakahara T, Takahashi Y, Hattori N: Atypical Miller Fisher syndrome associated with glutamate receptor antibodies. BMJ Case Rep, 2011

Shimizu Y, Fujihara K, Kubo S, Takahashi T, Misu T, Nakashima I, Yokoyama K, Itoyama Y, Uchiyama S. Therapeutic efficacy of interferon β-1b in Japanese patients with optic-spinal multiple sclerosis. Tohoku J Exp Med. 2011;223(3):211-4.

Suzuki S, Utsugisawa K, Yoshikawa H, Motomura M, Matsubara S, Yokoyama K, Nagane Y, Maruta T, Satoh T, Sato H, Kuwana M, Suzuki N.
Autoimmune targets of heart and skeletal muscles in myasthenia gravis.
Arch Neurol. 2009 Nov;66(11):1334-8.

Satoh J, Nakanishi M, Koike F, Onoue H, Aranami T, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Saito T, Ohta M, Miyake S, Kanda T, Fukazawa T, Yamamura T.　T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patient
J Neuroimmunol. 2006 May;174(1-2):108-18.

Satoh J, Nakanishi M, Koike F, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T.
Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis.
Neurobiol Dis. 2005 Apr;18(3):537-50.

Koike F, Satoh J, Miyake S, Yamamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T.　Microarray analysis identifies interferon beta-regulated genes in multiple sclerosis.
J Neuroimmunol. 2003 Jun;139(1-2):109-18.

Kawamura K, Yamamura T, Yokoyama K, Chui DH, Fukui Y, Sasazuki T, Inoko H, David CS, Tabira T.
Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice.
J Clin Invest. 2000 Apr;105(7):977-84.

Yamamura T, Geng TC, Kozovska MF, Yokoyama K, Cohen IR, Tabira T.
An alpha-chain TCR CDR3 peptide can enhance EAE induced by myelin basic protein or proteolipid protein.
J Neurosci Res. 1996 Sep 15;45(6):706-13.
著書
横山和正　今日の治療指針　2022　急性散在性脳脊髄炎　医学書院　974-975、2022
横山和正、服部信孝．コロナ禍での実臨床における多発性硬化症診療、医学と薬学　自然科学社　2022(4):481-492、2022
横山和正、服部信孝脳神経内科診断ハンドブック　サルコイドーシスによる神経・筋障害中外医学書266-272,2022
横山和正、服部信孝．CD20抗体　オファツムマブ(解説/特集)、Clinical Neuroscience 39:1499-1504, 2021
横山和正、服部信孝．【多発性硬化症と視神経脊髄炎update-基礎・臨床研究の最新知見-】脱髄性疾患の治療update　中枢神経脱髄性疾患の対症療法と生活指導・患者説明(解説/特集)、日本臨床 79:1638-1649, 2021
横山和正、服部信孝．【多発性硬化症治療の現状】多発性硬化症治療薬と感染症、脳神経内科　90:445-453, 2019
下畑享良、久保真人、饗場郁子、服部信孝、吉田一人、海野佳子、横山和正、小川崇、加世田ゆみ子、小池亮子、清水優子、坪井義夫、道勇学、三澤園子、宮地隆史、戸田達史、武田篤、日本神経学会キャリア形成促進委員会
小川崇、横山和正、服部信孝. 【燃え尽き症候群】燃え尽き症候群とは何か(解説/特集)、脳神経内科　94:230-235, 2021
横山和正、服部信孝．【多発性硬化症治療の現状】多発性硬化症治療薬と感染症(解説/特集)、脳神経内科　90:445-453, 2019
横山和正、服部信孝．【診療力を上げる!　症例問題集】(第7章)神経・筋　症例問題　急性発症の統合失調様精神症状を呈した女性(解説/特集)、内科 123:899-901, 2019
横山和正、小川崇、服部信孝．医師のバーンアウト(燃え尽き症候群)をふせぐためには?　脳神経内科領域の取組みから学ぶ　大学における燃え尽き症候群の課題と対策(解説)、医学のあゆみ 268:1017-1020, 2019
横山和正、服部信孝．【診療力を上げる!　症例問題集】(第7章)神経・筋　症例問題　急性発症の統合失調様精神症状を呈した女性(解説/特集)、内科 123:899-901, 2019
解説/特集
横山和正(順天堂大学医学部脳神経内科), 佐藤竜介, 牧岡大器, 飯塚幸彦, 長谷昌知, Yan Ling, 鳥居慎一, 齋田孝彦
背景因子別にみたナタリズマブの日本人多発性硬化症に対する有効性　ナタリズマブ使用成績調査中間解析から(第二報)(原著論文)
診療と新薬 (0037-380X)55巻6号 Page449-456(2018.06)
横山和正(順天堂大学医学部脳神経内科学講座), 服部信孝
【痛み関連の神経内科疾患】多発性硬化症の痛みの病態とマネージメント(解説/特集)
ペインクリニック (0388-4171)39巻9号 Page1169-1178(2018.09)
藤田翔平(順天堂大学医学部放射線診断学講座), 堀正明, 萩原彰文, 前川朋子, アンディカ・クリスティナ , 入江隆介, 鎌形康司, 神谷昂平, 横山和正, 青木茂樹
【Step up MRI 2018　MRI新技術　基礎から臨床への橋渡し】MRIの新技術　臨床編　頭部領域におけるMRIの新技術と臨床応用　OGSE-DWIとsynthetic MRIを中心に(解説/特集)
INNERVISION (0913-8919)33巻9号 Page45-48(2018.08)
横山和正(順天堂大学医学部脳神経内科), 服部信孝
【パーキンソン病(第2版)-基礎・臨床研究のアップデート-】検査・診断　関連疾患　脳炎後パーキンソニズム(解説/特集)
日本臨床 (0047-1852)76巻増刊4 パーキンソン病 Page388-395(2018.05)

【神経内科検査のみかた-脳のイメージングを中心に】どんなイメージがあるの?　神経疾患と抗体
Author：横山和正(順天堂大学医学部神経学講座)
Source：Modern Physician(0913-7963)33巻5号 Page615-620(2013.05)

富沢雄二, 横山和正, 服部信孝.【NMO spectrumとAQP4の病態意義】 Tumefactive MSとNMO spectrum disorderのextensive brain lesion(解説/特集). 神経内科 76(6):549-553, 2012年6月

富沢雄二, 横山和正, 服部信孝.【内科疾患と脳神経疾患:診断と治療の進歩】膠原病と脳神経疾患(解説/特集). 日本内科学会雑誌 101(8):2242-2248, 2012年8月
横山和正．患者への説明のポイント　－　多発性硬化症（MS）診療のすべて、フィンゴリモド（FTY720）、編者　山村隆、診断と治療社、2012年

横山和正．最新アプローチ　多発性硬化症と視神経脊髄炎、専門編集　吉良潤一、中山書店、2012年　

清水優子, 藤原一男, 久保幸子, 三須建郎, 富澤雄二, 横山和正, 高橋利幸, 服部信孝, 糸山泰人, 内山真一郎. 多発性硬化症と視神経脊髄炎における髄液ミエリン塩基性蛋白(MBP). 医学と薬学. 巻2号 Page281-286(2010.08)

横山和正. 【医師不足時代の神経内科医療の在り方　都市と地方での医療デバイド】大都市医学部附属病院からみた神経内科不足の現状分析とその対策. 神経内科. 巻4号 Page374-379(2010.10)

横山和正.シリーズ　難治性疾患の今　～臨床のピットフォール～　第6回　重症筋無力症Medical tribune 2010年9月9日発行号（VOL 43，No.36）Ｐ５０

横山和正. 【膠原病と神経疾患　基礎から臨床まで】　神経膠原病各論　神経内科医から、膠原病科医から関節リウマチ　神経内科から　神経診断入門. Clinical Neuroscience. 巻2号 Page175-180(2010.02)

横山和正【免疫性神経疾患　新たな治療戦略に向けて】治療の実際　作用機序と適応・効果・副作用　ステロイド. 内科. 巻5号 Page816-823(2010.05)

横山和正. 【眼球運動の生理と病態】各種疾患での眼球運動障害　多発性硬化症. Clinical Neuroscience. 巻1号 Page88-91(2010.01)

研究者

教育活動

【学校法人順天堂】研究者情報データベース

研究業績詳細

横山 和正（ヨコヤマ カズマサ）

横山和正（ヨコヤマカズマサ）