原著論文

1. Simpson SV, Nundu SS, Arima H, Kaneko O, Mita T, Culleton R, Yamamoto T. Malar J. 2023 Mar 20;22(1):102. 10.1186/s12936-023-04528-z

原著論文

1. Mita T, Fukuda N, Balikagala B. Evidence of Artemisinin-Resistant Malaria in Africa. Reply. N Engl J Med. 2022;386:1386. 10.1056/NEJMc2117480
2. Fukuda N, Balikagala B, Ueno T, Anywar DA, Kimura E, Palacpac NMQ, Odongo-Aginya EI, Ogwang M, Horii T, Miida T, Mita T. The impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa. Clin Infect Dis. 2022. 10.1093/cid/ciac944
3. Nundu SS, Culleton R, Simpson SV, Arima H, Chitama BA, Muyembe JJ, Ahuka S, Kaneko O, Mita T, Yamamoto T. Identification of polymorphisms in genes associated with drug resistance in Plasmodium falciparum isolates from school-age children in Kinshasa, Democratic Republic of Congo. Parasitol Int. 2022:88.102541. 10.1016/j.parint.2022.102541
4. Nundu SS, Arima H, Simpson SV, Chitama BA, Munyeku YB, Muyembe JJ, Mita T, Ahuka S, Culleton R, Yamamoto T. Low prevalence of Plasmodium falciparum parasites lacking pfhrp2/3 genes among asymptomatic and symptomatic school-age children in Kinshasa, Democratic Republic of Congo. Malar J. 2022;21:126. 10.1186/s12936-022-04153-2
5. Zhang X, Ishikawa D, Nomura K, Fukuda N, Haraikawa M, Haga K, Shibuya T, Mita T, Nagahara A. Donor Screening Revisions of Fecal Microbiota Transplantation in Patients with Ulcerative Colitis. J Clin Med. 2022;11. 10.3390/jcm11041055
6. Ichimura Y, Yamauchi M, Yoshida N, Miyano S, Komada K, Thandar MM, Tiwara S, Mita T, Hombhanje FW, Mori Y. Effectiveness of immunization activities on measles and rubella immunity among individuals in East Sepik, Papua New Guinea: A cross-sectional study. IJID Regions. 2022;3:84-8. 10.1016/j.ijregi.2022.03.001
7. Coppee R, Bailly J, Sarrasin V, Vianou B, Zinsou BE, Mazars E, Georges H, Hamane S, Lavergne RA, Dannaoui E, Balikagala B, Fukuda N, Odongo-Aginya EI, Mita T, Houze S, Clain J, French National Malaria Reference Center Study G. Circulation of an artemisinin-resistant malaria lineage in a traveller returning from East Africa to France. Clin Infect Dis. 2022. 10.1093/cid/ciac162
8. Takamiya S, Nakamura T, Tsubokawa D, Tsuji N, Fukuda K, Yamasaki H, Fujimura T, Taka H, Kaga N, Kobayashi-Tanabe M, Matsuda M, Mita T. Biochemical characterization of mitochondria from adult worms and plerocercoid larvae of Spirometra mansoni shows mixed populations of anaerobic and aerobic mitochondria.Parasitol Int.2022;92:102695. 10.1016/j.parint.2022.102695
9. Nundu SS, Simpson SV, Arima H, Muyembe J-J, Mita T, Ahuka S, Yamamoto T. It Is Time to Strengthen the Malaria Control Policy of the Democratic Republic of Congo and Include Schools and School-Age Children in Malaria Control Measures.Pathogens. 2022;11:729.10.3390/pathogens11070729
10. Janwan P, Sadaow L, Rodpai R, Yamasaki H, Luvira V, Sukeepaisarnjaroen W, Kitkhuandee A, Paonariang K, Sanpool O, Boonroumkaew P. Evaluation of total immunoglobulin G and subclass antibodies in an enzyme-linked immunosorbent assay for serodiagnosis of human amebic liver abscess.Peer J. 2022;10:e14085.

原著論文

1. Balikagala B, Fukuda N, Ikeda M, Katuro OT, Tachibana SI, Yamauchi M, Opio W, Emoto S, Anywar DA, Kimura E, Palacpac NMQ, Odongo-Aginya EI, Ogwang M, Horii T, Mita T. Evidence of Artemisinin-Resistant Malaria in Africa. N Engl J Med. 2021;385:1163-71. 10.1056/NEJMoa2101746
2. Mita T, Hirai M, Maki Y, Nahar S, Yoshida N, Oshima Y, Kikuchi H, Kubohara Y. Derivatives of Dictyostelium differentiation-inducing factors suppress the growth of Plasmodium parasites in vitro and in vivo. Biochem Pharmacol. 2021:114834. 10.1016/j.bcp.2021.114834
3. Hirai M, Maeta A, Mori T and Mita T. Pb103 Regulates Zygote/Ookinete Development in Plasmodium berghei via Double Zinc Finger Domains. Pathogens. 2021;10(12): 1536. 10.3390/pathogens10121536
   
4. Yoshida N, Yamauchi M, Morikawa R, Hombhanje F, Mita T. Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea. Malar J. 2021;20:410. 10.1186/s12936-021-03933-6
5. Pattanawong U, Putaporntip C, Kakino A, Yoshida N, Kobayashi S, Yanmanee S, Jongwutiwes S, Tachibana H. Analysis of D-A locus of tRNA-linked short tandem repeats reveals transmission of Entamoeba histolytica and E. dispar among students in the Thai-Myanmar border region of northwest Thailand. PLoS Negl Trop Dis. 2021;15:e0009188. 10.1371/journal.pntd.0009188
6. Shinjoh M, Furuichi M, Narabayashi A, Kamei A, Yoshida N, Takahashi T. Risk factors in pediatric hospitalization for influenza A and B during the seven seasons immediately before the COVID-19 era in Japan. J Infect Chemother. 2021. 10.1016/j.jiac.2021.08.020
   
7. Kubo-Irie M, Hirai M, Irie M, Mohri H. Postulated Process of Axoneme Organization in the Male Gametogenesis of Malaria Parasite Plasmodium berghei. Zoolog Sci. 2021;38:187-92. 10.2108/zs200064
   
8. Ikeda M, Hirai M, Tachibana SI, Mori T, Mita T. Isolation of Mutants With Reduced Susceptibility to Piperaquine From a Mutator of the Rodent Malaria Parasite Plasmodium berghei. Front Cell Infect Microbiol. 10.3389/fcimb.2021.672691
   
9. Yamauchi M, Hirai M, Tachibana SI, Mori T, Mita T. Fitness of sulfadoxine-resistant Plasmodium berghei harboring a single mutation in dihydropteroate synthase (dhps). Acta Trop. 2021:106049. 10.1016/j.actatropica.2021.106049
   
10. Nundu SS, Culleton R, Simpson SV, Arima H, Muyembe JJ, Mita T,Ahuka S, Yamamoto T. Malaria parasite species composition of Plasmodium infections among asymptomatic and symptomatic school-age children in rural and urban areas of Kinshasa, Democratic Republic of Congo. Malar J. 2021;20:389. 10.1186/s12936-021-03919-4
    
11. Fukuda N, Tachibana SI, Ikeda M, Sakurai-Yatsushiro M, Balikagala B, Katuro OT, Yamauchi M, Emoto S, Hashimoto M, Yatsushiro S, Sekihara M, Mori T, Hirai M, Opio W, Obwoya PS, Auma MA, Anywar DA, Kataoka M, Palacpac NMQ, Odongo-Aginya EI, Kimura E, Ogwang M, Horii T, Mita T. Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in Northern Uganda. Parasitol Int. 2021;81:102277. 10.1016/j.parint.2020.102277

原著論文

1. Hashimoto M, Yokota K, Kajimoto K, Matsumoto M, Tatsumi A, Yamamoto K, Hyodo T, Matsushita K, Minakawa N, Mita T, Oka M, Kataoka M. Quantitative Detection of Plasmodium falciparum Using, LUNA-FL, A Fluorescent Cell Counter. Microorganisms. 2020;8:1356. PMID:32899795
2. Yamamoto T, Hashimoto M, Nagatomi K, Nogami T, Sofue Y, Hayashi T, Ido Y, Yatsushiro S, Abe K, Kajimoto K, Tamari N, Awuor B, Sonye G, Kongere J, Munga S, Ohashi J, Oka H, Minakawa N, Kataoka M, Mita T. Development of a quantitative, portable, and automated fluorescent blue-ray device-based malaria diagnostic equipment with an on-disc SiO2. Sci Rep 2020. 10:6585.
3. Balikagala B, Sakurai-Yatsushiro M, Tachibana SI, Ikeda M, Yamauchi M, Katuro OT, Ntege EH, Sekihara M, Fukuda N, Takahashi N, Yatsushiro S, Mori T, Hirai M, Opio W, Obwoya PS, Anywar DA, Auma MA, Palacpac NMQ, Tsuboi T, Odongo-Aginya EI, Kimura E, Ogwang M, Horii T, Mita T. Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda. Malaria J 2020. 19:76. PMID: 32070358
4. Hashimoto M, Yokota K, Kajimoto K, Matsumoto M, Tatsumi A, Nakajima Y, Mita T, Minakawa N, Oka H, Kataoka M. Highly Sensitive and Rapid Quantitative Detection of Plasmodium falciparum Using an Image Cytometer.　Microorganisms 　2020;8.10.3390/microorganisms8111769
5. Araki T, Kawai S, Kakuta S, Kobayashi H, Umeki Y, Saito-Nakano Y, Sasaki T, Nagamune K, Yasutomi Y, Nozaki T, Franke-Fayard B, Khan SM, Hisaeda H, Annoura T. Three-dimensional electron microscopy analysis reveals endopolygeny-like nuclear architecture segregation in Plasmodium oocyst development. Parasitol Int 2020;76:102034. 10.1016/j.parint.2019.102034
6. Kanoi BN, Nagaoka H, White MT, Morita M, Palacpac NMQ, Ntege EH, Balikagala B, Yeka A, Egwang TG, Horii T, Tsuboi T, Takashima E. Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population. Front Immunol. 2020;11:893. 10.3389/fimmu.2020.00893
7. Ohashi Y, Mori T, Igawa T. Behavior of filamentous temperature-sensitive Z2 (FtsZ2) in the male gametophyte during sexual reproduction processes of flowering plants. Protoplasma. 2020;257:1201-10. 10.1007/s00709-020-01503-2
8. Tachibana SI, Matsuzaki S, Tanaka M, Shiota M, Motooka D, Nakamura S, Goto SG. The Autophagy-Related Protein GABARAP Is Induced during Overwintering in the Bean Bug (Hemiptera: Alydidae). J Econ Entomol. 2020;113:427-34. 10.1093/jee/toz287
9. Takahashi T, Mori T, Igawa T. Restricted Pollination for Tracing Individual Pollen Tubes in a Pistil. Methods Mol Biol. 2020;2160:73-81. 10.1007/978-1-0716-0672-8_5
10. Miotto O, Sekihara M, Tachibana SI, Yamauchi M, Pearson RD, Amato R, Gonçalves S, Mehra S, Noviyanti R, Marfurt J, Auburn S, Price RN, Mueller I, Ikeda M, Mori T, Hirai M, Tavul L, Hetzel MW, Laman M, Barry AE, Ringwald P, Ohashi J, Hombhanje F, Kwiatkowski DP, Mita T. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea. PLoS Pathog.2020 Dec 15;16(12):e1009133. doi: 10.1371/journal.ppat.1009133. Online ahead of print. PMID: 33320907

原著論文

1. Hashimoto M, Bando M, Kido JI, Yokota K, Mita T, Kajimoto K, Kataoka M. Nucleic acid purification from dried blood spot on FTA Elute Card provides template for polymerase chain reaction for highly sensitive Plasmodium detection. Parasitol Int 2019. 73:101941. PMID: 31442664
2. Yamamoto T, Yatsushiro S, Hashimoto M, Kajimoto K, Ido Y, Abe K, Sofue Y, Nogami T, Hayashi T, Nagatomi K, Minakawa N, Oka H, Mita T, Kataoka M. Development of a highly sensitive, quantitative, and rapid detection system for Plasmodium falciparum-infected red blood cells using a fluorescent blue-ray optical system. Biosens Bioelectron 2019. 132: 375-381.PMID: 30901727
3. Mori T, Hirai M, Mita T. See-through observation of malaria parasite behaviors in the mosquito vector. Sci Rep 2019. 9:1768. PMID: 30742010
4. Balogun EO, Inaoka DK, Shiba T, Tsuge C, May B, Sato T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PAM, Watanabe YI, Moore AL, Harada S, Kita K. Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei. Faseb j. 2019;33:13002-13. 10.1096/fj.201901342R
5. Nakashima Y, Nahar S, Miyagi-Shiohira C, Kinjo T, Kobayashi N, Kitamura S, Saitoh I, Watanabe M, Fujita J, Noguchi H. Identification of Proteins Differentially Expressed by Adipose-derived Mesenchymal Stem Cells Isolated from Immunodeficient Mice. Int J Mol Sci. 2019;20. 10.3390/ijms20112672
6. Shiba T, Inaoka DK, Takahashi G, Tsuge C, Kido Y, Young L, Ueda S, Balogun EO, Nara T, Honma T, Tanaka A, Inoue M, Saimoto H, Harada S, Moore AL, Kita K. Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase. Biochim Biophys Acta Bioenerg. 2019;1860:375-82. 10.1016/j.bbabio.2019.03.008
7. Subissi L, Kanoi BN, Balikagala B, Egwang TG, Oguike M, Verra F, Proietti C, Bousema T, Drakeley CJ, Sepulveda N. Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda. Trans R Soc Trop Med Hyg. 2019;113:370-8. 10.1093/trstmh/trz015
8. Yoshii A, Sekihara M, Furusawa T, Hombhanje F, Tsukahara T. Factors associated with children's health facility visits for primaquine treatment in rural Papua New Guinea. Malar J. 2019;18:42. 10.1186/s12936-019-2675-4
9. Araki T, Kawai S, Kakuta S, Kobayashi H, Umeki Y, Saito-Nakano Y, Sasaki T, Nagamune K, Yasutomi Y, Nozaki T, Franke-Fayard B, Khan SM, Hisaeda H, Annoura T. Three-dimensional electron microscopy analysis reveals endopolygeny-like nuclear architecture segregation in Plasmodium oocyst development. Parasitol Int. 2020;76:102034. 10.1016/j.parint.2019.102034
10. Tomiki Y, Saito K, Arikawa-Hirasawa ERI, Mita T, Shimizu T, Suzuki T, Ohnuma T, Ohtomo Y, Nagaoka I. Club Activities of Medical Students at Juntendo University - Changes of Membership over the 30-year Heisei Era. Juntendo Medical Journal. 2019;65:172-8. 10.14789/jmj.2019.65.JMJ18-Re03

総説

1. Mita T. Epidemiology of severe fever with thrombocytopenia syndrome in Japan. Juntendo Medical Journal 2019. 65:130-135. J-STAGE
2. Nahar S, Hokama A, Fujita J. Clinical significance of cytomegalovirus and other herpes virus infections in ulcerative colitis. Pol Arch Intern Med. 2019;129:620-6. 10.20452/pamw.14835

原著論文

1. Sekihara M, Tachibana S-I, Yamauchi M, Yatsushiro S, Tiwara S, Fukuda N, Ikeda M, Mori T, Hirai M, Hombhanje F, Mita T. Lack of significant recovery of chloroquine sensitivity in Plasmodum falciparum parasites following discontinuance of chloroquine use in Papua New Guinea. Malar J 2018. 17:434.PMID: 30477515
2. Mita T, Hombhanje F, Takahashi N, Sekihara M, Yamauchi M, Tsukahara T, Kaneko A, Endo H, Ohashi J. Rapid selection of sulphadoxine-resistant Plasmodium falciparum and its effect on within-population genetic diversity in Papua New Guinea. Sci Rep 2018. 8:5565. PMID: 29615786
3. Ikeda M, Kaneko M, Tachibana S-I, Balikagala B, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Yamauchi M, Sekihara M, Hashimoto M, Katuro OT, Olia A, Obwoya PS, Auma MA, Anywar DA, Odongo-Aginya EI, Okello-Onen J, Hirai M, Ohashi J, Palacpac NMQ, Kataoka M, Tsuboi T, Kimura E, Horii T, Mita T. Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014–2016. Emerg Infect Dis 2018. 24(4): 718-726. PMID: 29553316_
4. Rodrigues PT, Valdivia HO, de Oliveira TC, Alves JMP, Duarte AMRC, Cerutti-Junior C, Buery JC, Brito CFA, de Souza JC Jr, Hirano ZMB, Bueno MG, Catão-Dias JL, Malafronte RS, Ladeia-Andrade S, Mita T, Santamaria AM, Calzada JE, Tantular IS, Kawamoto F, Raijmakers LRJ, Mueller I, Pacheco MA, Escalante AA, Felger I, Ferreira MU. Human migration and the spread of malaria parasites to the New World. Sci Rep 2018. 8(1):1993. PMID: 29386521
5. Hombhanje F, Sekihara M, Hombhanje M, Pawiying J, Baigry M, Mallembo M,Mita T. Molecular evidence of asymptomatic and multispecies malaria infections in a small community on the north coast of Madang Province,Papua New Guinea. Papua New Guinea Medical Journal 2018.61:1-4
6. Takahashi T, Mori T, Ueda K, Yamada L, Nagahara S, Higashiyama T, Sawada H, Igawa T. The male gamete membrane protein DMP9/DAU2 is required for double fertilization in flowering plants. Development. 2018;145. 10.1242/dev.17007
7. Yamashita Y, Nakada S, Yoshihara T, Nara T, Furuya N, Miida T, Hattori N, Arikawa-Hirasawa E. Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep. 2018;8:7766. 10.1038/s41598-018-25635-x

原著論文

1. Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin B-H, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. PLoS Genet 2017. 13(8): e1006950. PMID: 28854265
2. Balikagala B, Mita T, Ikeda M, Sakurai M, Yatsushiro S, Takahashi N, Tachibana S-I, Auma M, Ntege EH, Ito D, Takashima E, Palacpac NMQ, Egwang TG, Onen JO, Kataoka M, Kimura E, Horii T, Tsuboi T. Absence of in-vivo selection for K13 mutations after artemether-lumefantrine treatment in Uganda. Malar J 2017. 16: 23. PMID: 28068997
3. Hase H, Koukai M, Hamanaka Y, Goto SG, Tachibana SI, Shiga S. Transcriptome analysis of the brain under diapause and nondiapause conditions in the blowfly Protophormia terraenovae. Physiological Entomology. 2017;42:282-9. 10.1111/phen.12205
4. Igawa T, Yamada L, Sawada H, Mori T. Isolation of GFP-tagged plasma membrane protein from Arabidopsis egg cells. Plant Biotechnol (Tokyo). 2017;34:119-23. 10.5511/plantbiotechnology.17.0522a
5. Miyado K, Kang W, Yamatoya K, Hanai M, Nakamura A, Mori T, Miyado M, Kawano N. Exosomes versus microexosomes: Shared components but distinct functions. J Plant Res. 2017;130:479-83. 10.1007/s10265-017-0907-7
6. Takahashi T, Honda K, Mori T, Igawa T. Loss of GCS1/HAP2 does not affect the ovule-targeting behavior of pollen tubes. Plant Reprod. 2017;30:147-52. 10.1007/s00497-017-0305-2
7. Yamamoto K, Kawai-Toyooka H, Hamaji T, Tsuchikane Y, Mori T, Takahashi F, Sekimoto H, Ferris PJ, Nozaki H. Molecular evolutionary analysis of a gender-limited MID ortholog from the homothallic species Volvox africanus with male and monoecious spheroids. PloS One. 2017;12:e0180313. 10.1371/journal.pone.0180313

著書、報告等

1. 美田敏宏. マラリア. 臨床と微生物 2017. 44: 263-268. Webサイト

総説

1. Mita T, Tachibana S-I, Hashimoto M, Hirai M. Plasmodium falciparum kelch13: a potential molecular marker for tackling artemisinin-resistant malaria parasites. Expert Rev Anti Infect There 2016. 14: 125-135. PMID: 26535806

原著論文

1. Honma H, Niikura M, Kobayashi F, Horii T, Mita T, Endo H, Hirai M. Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ. Sci Rep 2016. 15; 6: 36971. PMID: 27845384_
2. Pongvongsa T, Nonaka D, Iwagami M, Nakatsu M, Phongmany P, Nishimoto F, Kobayashi J, Hongvanthon B, Brey PT, Moji K, Mita T, Kano S. Household clustering of asymptomatic malaria infections in Xepon district, Savannakhet province, Lao PDR. Malar J 2016. 15: 508. PMID: 27756391
3. Bautista-Lopez N, Ndao M, Camargo F, Nara T, Jardim A, Annoura T, Hardie D, Borchers C. Characterization and diagnostic application of Trypanosoma cruzi trypomastigote excreted-secreted antigens shed in exosomes released from infected mammalian cells. J Clin Microbiol 2016. in press. Web link
4. Inaoka DK, Iida M, Tabuchi T, Honma T, Lee N, Hashimoto S, Matsuoka S, Kuranaga T, Sato K, Shiba T, Sakamoto K, Balogun EO, Suzuki S, Nara T, da Rocha JR, Montanari CA, Tanaka A, Inoue M, Kita K, Harada S. The open form inducer approach for structure-based drug design. PLoS ONE 2016. 11: e0167078. PMID: 27893848
5. Hoshika Y, Takahashi F, Togo S, Hashimoto M, Nara T, Kobayashi T, Nurwidya F, Kataoka H, Kurihara M, Kobayashi E, Ebana H, Kikkawa M, Ando K, Nishino K, Hino O, Takahashi K, Seyama K. Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dubé syndrome. Physiol Rep 2016. 4: e13025. PMID: 27905298
6. Hashimoto M, Doi M, Kurebayashi N, Furukawa K, Hirawake-Mogi H, Ohmiya Y, Sakurai T, Mita T, Mikoshiba K, Nara T. Inositol 1,4,5-trisphosphate receptor determines intracellular Ca2+ concentration in Trypanosoma cruzi throughout its life cycle. FEBS Open Bio 2016. 6: 1178-85. Web link
7. Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepción JL, Hashimoto T, Embley TM, Nara T. Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids. Proc R Soc B 2016. 283 (1830): 20160520. PMID: 27170716
8. Takamiya S, Mita T. Large-scale purification of active liquid-cultured Caenorhabditis elegans using a modified Barman apparatus. Parasites Int 2016. 65: 580-3. PMID: 27072792
9. Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Björkman A, Endo H, Ohashi J. Little polymorphism at the K13 propeller locus in worldwide Plasmodium falciparum populations prior to the introduction of artemisinin combination therapies. Antimicrob Agents Chemother 2016. 60: 3340-7. PMID: 27001814
10. Tsubokawa D, Sugiyama H, Mikami F, Shibata K, Shibahara T, Fukuda K, Takamiya S, Yamasaki H, Nakamura T, Tsuji N. Collection methods of trematode eggs using experimental animal models. Parasitol Int 2016. 65: 584-7. PMID: 26792074
11. Hashimoto M, Nara T, Mita T, Mikoshiba K. Morpholino antisense oligo inhibits trans-splicing of pre-inositol 1, 4, 5-trisphosphate receptor mRNA of Trypanosoma cruzi and suppresses parasite growth and infectivity. Parasitol Int 2016. 65: 175-9. PMID: 26680159
12. Takamiya S, Hashimoto M, Mita T, Yokota T, Nakajima Y, Yamakura F, Sugio S, Fujimura T, Ueno T, Yamasaki H. Bioinformatic identification of cytochrome b5 homologues from the parasitic nematode Ascaris suum and the free-living nematode Caenorhabditis elegans highlights the crucial role of A. suum adult-specific secretory cytochrome b5 in parasitic adaptation. Parasitol Int 2016. 65: 113-20. PMID: 26571414

総説

1. Nara T, Miura S. Current situation of Chagas disease in non-endemic countries. Juntendo Med J 2015. 61: 389-95. Webサイト
2. Hirai M, Mita T. Challenging malaria control: do our new genetic tools pave the way for malaria eradication? Juntendo Med J 2015. 61: 370-7. Webサイト
3. Mita T. Current research topics in Tropical disease; toward the successful control and elimination; Introduction. Juntendo Med J 2015. 61: 358-9. Webサイト

原著論文

1. Tsukahara T, Ogura S, Sugahara T, Sekihara M, Furusawa T, Kondo N, Mita T, Endo H, Hombhanje F. The choice of healthcare providers for febrile children after introducing non-professional health workers in a malaria endemic area in Papua New Guinea. Front Public Health 2015 3:275. doi: 10.3389/fpubh.2015.00275
2. Hashimoto M, Nara T, Enomoto M, Kurebayashi N, Yoshida M, Sakurai T, Mita T, Mikoshiba K. A dominant negative form of inositol 1,4,5-trisphosphate receptor induces metacyclogenesis and increases mitochondrial density in Trypanosoma cruzi. Biochem Biophys Res Commun 2015. 466: 475-80. PMID: 26367178
3. Hashimoto M, Morales J, Uemura H, Mikoshiba K, Nara T. A novel method for inducing amastigote-to-trypomastigote transformation in vitro in Trypanosoma cruzi reveals the importance of inositol 1,4,5-trisphosphate receptor. PLOS ONE 2015. 10: e0135726. PMID: 26267656
4. Matsuoka H, Tomita H, Hattori R, Arai M, Hirai M. Visualization of malaria parasites in the skin using the luciferase transgenic parasite, Plasmodium berghei. Trop Med Health 2015. 43: 53-61. PMID: 25859153
5. Hikosaka K, Hirai M, Komatsuya K, Ono Y, Kita K. Lactate retards the development of erythrocytic stages of the human malaria parasite Plasmodium falciparum. Parasitol Int 2015. 64: 301-3. PMID: 25176135
6. Siregar JE, Kurisu G, Kobayashi T, Matsuzaki M, Sakamoto K, Mi-ichi F, Watanabe Y, Hirai M, Matsuoka H, Syafruddin D, Marzuki S, Kita K. Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex. Parasitol Int 2015. 64: 295-300. PMID: 25264100
7. Murai K, Culleton R, Hisaoka T, Endo H, Mita T. Global distribution of polymorphisms associated with delayed Plasmodium falciparum parasite clearance following artemisinin treatment: genotyping of archive blood samples. Parasitol Int 2015. 64: 267-73. PMID: 25449286
8. Tanabe K, Zollner G, Vaughan JA, Sattabongkot J, Khuntirat B, Honma H, Mita T, Tsuboi T, Coleman R. Plasmodium falciparum: genetic diversity and complexity of infections in an isolated village in western Thailand. Parasitol Int 2015. 64: 260-6. PMID: 24060540
9. Mita T, Jombart T. Patterns and dynamics of genetic diversity in Plasmodium falciparum: what past human migrations tell us about malaria. Parasitol Int 2015. 64: 238-43. PMID: 25305418
10. Hirai M. The things that Professor Tanabe left for us. Parasitol Int 2015. 64:xviii. PMID: 25263799

総説

1. Takamiya S. Reflection: how parasitic helminths adapt to environmental hypoxia: my wanderings in helminth biochemistry, Juntendo Med J 2014 60: 432-448. Webサイト

原著論文

1. Nurwidya F, Takahashi F, Kobayashi I, Murakami A, Kato M, Minakata K, Nara T, Hashimoto M, Yagishita S, Baskoro H, Hidayat M, Shimada N, Takahashi K. Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer. Biochem Biophys Res Commun 2014. 455: 332-8. PMID: 25446090
2. Balogun EO, Inaoka DK, Shiba T, Kido Y, Tsuge C, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Kita K, Harada S. Molecular basis for the reverse reaction of African human trypanosomes glycerol kinase. Mol Microbiol 2014. 94: 1315-29. PMID: 25315291
3. Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H. Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice. Int J Parasitol 2014. 44: 681-5. PMID: 24995619
4. Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu S, Palacpac NM, Hisaeda H, Matsuoka H, Kawai S, Endo H, Yasunaga T, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K. Generation of rodent malaria parasites with a high mutation rate by destructing proofreading activity of DNA polymerase δ. DNA Res 2014. 21: 439-46. PMID: 24670267
5. Hashimoto M, Nara T, Hirawake H, Morales J, Enomoto M, Mikoshiba K. Antisense oligonucleotides targeting parasite inositol 1,4,5-trisphosphate receptor inhibits mammalian host cell invasion by Trypanosoma cruzi. Sci Rep 2014. 4: 4231. PMID: 24577136
6. Mita T, Ohashi J, Venkatesan M, Marma AS., Plowe CV, Tanabe K. Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite. J Infect Dis 2014. 209: 130-9. PMID: 23922363
7. Murakami A, Takahashi F, Nurwidya F, Kobayashi I, Minakata K, Hashimoto M, Nara T, Kato M, Tajima K, Shimada N, Iwakami S, Moriyama M, Moriyama H, Koizumi F, Takahashi K. Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor. PLOS ONE 2014. 28: e86459. PMID: 24489728

著書、報告等

1. 坪川大悟、杉山広、三上房子、柴田勝優、柴原壽行、福田孝一、高宮信三郎、山崎浩、辻尚利、中村健. 実験動物を用いた吸虫卵採取の試み. 寄生虫学研究；材料と方法2014年版（編集：高宮信三郎）, 三恵社 2014 1-4.
2. 坪川大悟、三上房子、高宮信三郎、辻尚利、中村健. マンソン裂頭条虫プレロセルコイドのゲル内長期生存保存法. 寄生虫学研究；材料と方法2014年版（編集：高宮信三郎）, 三恵社 2014 37-38.
3. 高宮信三郎、橋本宗明、山崎浩、余涌、美田敏宏. ブタ回虫分泌型シトクロムｂ５前駆体の大腸菌における発現とその成熟蛋白の精製. 寄生虫学研究；材料と方法2014年版（編集：高宮信三郎）, 三恵社 2014 125-129.
4. 高宮信三郎、藤村務、峯木礼子、高ひかり、進藤典子、美田敏宏. ワンステップオルガネラ分画法を用いた線虫ミトコンドリアの調製：ミトコンドリアプロテオーム解析にむけて. 寄生虫学研究；材料と方法2014年版（編集：高宮信三郎）, 三恵社 2014 147-151.

原著論文

1. Khattak AA, Venkatesan M, Jacob CG, Artimovich EM, Nadeem MF, Nighat F, Mita T, Malik SA, Plowe CV. A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan. Malar J 2013. 12: 300. PMID: 23988011
2. Hunja CW, Unger H, Ferreira P, Lumsden R, Morris R, Aman R, Alexander C, Mita T, Culleton R. Travellers as Sentinels: Assaying the worldwide distribution of polymorphisms associated with ACT resistance in P. falciparum using malaria cases imported into Scotland. Int J Parasitol 2013. 43: 885–9. PMID: 23899818
3. Tanabe K, Jombart T, Horibe S, Palacpac N, Honma H, Tachibana S-I, Nakamura M, Horii T, Kishinod H, Mita T. Plasmodium falciparum mitochondrial genetic diversity exhibits isolation-by-distance patterns supporting a sub-Saharan African origin. Mitochondrion 2013. 13: 630-6. PMID: 24004956
4. Tanabe K, Mita T, Palacpac NM, Arisue N, Tougan T, Kawai S, Jombart T, Kobayashi F, Horii T. Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin. Vaccine 2013. 31: 1334-9. PMID: 23295064
5. Hashimoto M, Enomoto M, Morales J, Kurebayashi M, Hashimoto T, Nara T, Mikoshiba K. Inositol 1,4,5-Triphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist Trypanosoma cruzi. Mol Microbiol 2013. 87: 1133-50. PMID: 23320762
6. Shiba T, Kido Y, Sakamoto K, Inaoka DK, Tsuge C, Tatsumi R, Takahashi G, Balogun EO, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Saimoto H, Moore AL, Harada S, Kita K. Structure of the trypanosome cyanide-insensitive alternative oxidase. Proc Natl Acad Sci U S A 2013. 110: 4580-5. PMID: 23487766
7. Balogun EO, Inaoka DK, Shiba T, Kido Y, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Michels PA, Harada S, Kita K. Biochemical characterization of highly active Trypanosoma bruceigambiense glycerol kinase, a promising drug target. J Biochem 2013. 154: 77-84. PMID: 23620597

著書、報告等

1. 美田敏宏、北潔．寄生虫卵・虫体検査．特集「検査値を読む2013」．臨床雑誌内科. 2013. 111: 1049-50. Webサイト
2. 村井謙治、鈴木麻衣、鈴木彰人、石島聡子、渡辺由希子、乾啓洋、高宮信三郎、山﨑浩、内藤俊夫、美田敏宏、礒沼弘. 駆虫より咽頭違和感が消失した無鉤条虫症の1例. 日本臨床寄生虫学会誌 2013 24: 94-96.

総説

1. Mita T, Tanabe K. Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance. Jpn J Infect Dis 2012. 65: 465-75. PMID: 23183197

原著論文

1. Tachibana S-I, Sullivan SA, Kawai S, Nakamura S, Kim HR, Goto N, Arisue N, Palacpac N, Honma H, Yagi M, Tougan T, Katakai Y, Kaneko O, Mita T, Kita K, Yasutomi Y, Sutton PL, Shakhbatyan R, Horii T, Yasunaga T, Barnwell JW, Escalante AA, Carlton JM, Tanabe K. Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade. Nat Genet 2012. 44: 1051-5. PMID: 22863735
2. Tanabe K, Arisue N, Palacpac NM, Yagi M, Tougan T, Honma H, Ferreira MU, Färnert A, Björkman A, Kaneko A, Nakamura M, Hirayama K, Mita T, Horii T. Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5. Vaccine 2012. 30: 1583-93. PMID: 22230587
3. Takahashi N, Tanabe K, Tsukahara T, Dzodzomenyo M, Dysoley L, Khamlome B, Sattabongkot J, Nakamura M, Sakurai M, Kobayashi J, Kaneko A, Endo H, Hombhanje F, Tsuboi T, Mita T. A large scale survey for novel genotypes of the Plasmodium falciparum chloroquine-resistant pfcrt. Malar J 2012. 11: 92. PMID: 22453078
4. Annoura T, Makiuchi T, Sariego I, Aoki T, Nara T. SUMOylation of paraflagellar rod protein, PFR1, and its stage-specific localization in Trypanosoma cruzi. PLOS ONE 2012. 7: e37183. PMID: 22615934
5. Minakata K, Takahashi F, Nara T, Hashimoto M, Tajima K, Murakami A, Nurwidya F, Yae S, Koizumi F, Moriyama H, Seyama K, Nishio K, Takahashi K. Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors. Cancer Sci 2012. 103: 1946-54. PMID: 22863020
6. Nara T, Hashimoto M, Hirawake H, Liao CW, Fukai Y, Suzuki S, Tsubouchi A, Morales J, Takamiya S, Fujimura T, Taka H, Mineki R, Fan CK, Inaoka DK, Inoue M, Tanaka A, Harada S, Kita K, Aoki T. Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi. Biochem Biophys Res Commun 2012. 418: 140-3. PMID: 22245425
7. Hashimoto M, Morales J, Fukai Y, Suzuki S, Takamiya S, Tsubouchi A, Inoue S, Inoue M, Kita K, Harada S, Tanaka A, Aoki T, Nara T. Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm. Biochem Biophys Res Commun 2012 417: 1002-6. PMID: 22209850
8. Chu T, Liao C, Huang Y, Chang Y, Costa A, Ji D, Nara T, Tsubouchi A, Chang PW, Chiu W, Fan C. Prevalence of Schistosoma intercalatum and S. haematobium Infection among Primary Schoolchildren in Capital Areas of Democratic Republic Of Sao Tome and Principe, West Africa. Iran J Parasitol 2012 7: 67-72. PMID: 23133474
9. Chu TB, Liao CW, Nara T, Huang YC, Chou CM, Liu YH, Fan CK . Enterobius vermicularis infection is well controlled among preschool children in nurseries of Taipei City, Taiwan. Rev Soc Bras Med Trop 2012 45: 646-8. PMID: 23152352
10. Fan CK, Liao CW, Lyu SY, Sukati H, Ji DD, Cho CM, Jien JY, Huang YC, Chang PW, Chiu WT, Nara T, Tsubouchi A, Huang YH, Tu CC, Lan SJ, Chao JC. Prevalence of intestinal parasitic infections among primary schoolchildren in areas devoid of sanitation in northwestern Kingdom of Swaziland, Southern Africa. Pathog Glob Health 2012 106: 60-2. PMID: 22595276
11. Fan CK, Lee LW, Liao CW, Huang YC, Lee YL, Chang YT, da Costa Ados S, Gil V, Chi LH, Nara T, Tsubouchi A, Akinwale OP. Toxoplasma gondii infection: relationship between seroprevalence and risk factors among primary schoolchildren in the capital areas of Democratic Republic of Sao Tome and Principe, West Africa. Parasit Vectors 2012 5:141. PMID: 22794195

著書、報告等

1. 美田敏宏、塚原高広、高橋延之、遠藤弘良. 薬剤耐性熱帯熱マラリア原虫の急速な選択は原虫集団の遺伝的多様性を低下させうるか. 東京女子医科大学総合研究所紀要 2012 32.
2. 高宮信三郎. 皮下組織および腸腔寄生蠕虫をモデルとしたハイポキシア耐性動物の生存戦略：寄生線虫ブタ回虫シトクロムb５. 平成23年度順天堂ハイテクリサーチセンター環境医学研究所紀要 2012 43-46.

原著論文

1. Makiuchi T, Annoura T, Hashimoto M, Hashimoto T, Aoki T, Nara T. Compartmentalization of a glycolytic enzyme in Diplonema, a non-kinetoplastid euglenozoan. Protist 2011 162: 482-9. PMID: 21377422
2. Liao CW, Sukati H, Nara T, Tsubouchi A, Chou CM, Jian JY, Huang YC, Chang PW, Chiu WT, Huang YH, Fan CK. Prevalence of Schistosoma haematobium infection among schoolchildren in remote areas devoid of sanitation in northwestern Swaziland, Southern Africa. Jpn J Infect Dis 2011 64: 322-6. PMID: 21788709
3. Tajima K, Miura K, Ishiwata T, Takahashi F, Yoshioka M, Minakata K, Murakami A, Sasaki S, Iwakami S, Annoura T, Hashimoto M, Nara T, Takahashi K. Sex hormones alter Th1 responses and enhance granuloma formation in the lung. Respiration 2011 81: 491-498. PMID: 21454951

著書、報告等

1. 高宮信三郎. ハイポキシア耐性動物にみられる低酸素適応機構. 平成22年度順天堂ハイテクリサーチセンター環境医学研究所紀要 2011 96-8.
2. 木村有太子、須賀康、水野優起、松葉祥一、山﨑浩、高宮信三郎、青木孝. キチマダニ刺咬症の1例. 臨床皮膚科 2011 65: 269-273.Webサイト

原著論文

1. Hashimoto M, Murata E, Aoki T. Secretory protein with RING finger domain (SPRING) specific to Trypanosoma cruzi is directed, as a ubiquitin ligase related protein, to the nucleus of host cells. Cell Microbiol 2010 12: 19-30. PMID: 19702650
2. Takamiya S, Fukuda K, Nakamura T, Aoki T, Sugiyama H. Paragonimus westermani possesses aerobic and anaerobic mitochondria in different tissues, adapting to fluctuating oxygen tension in microaerobic habitats. Int J Parasitol 2010 40: 1651-8. PMID: 20716443

原著論文

1. Takamiya S, Hashimoto M, Kazuno S, Kikkawa M, Yamakura F. Ascaris suum NADH-methemo(myo)globin reductase systems recovering differential functions of hemoglobin and myoglobin, adapting to environmental hypoxia. Parasitol Int 2009 58: 278-284. PMID: 19332145
2. Bao Y, Weiss LM, Hashimoto M, Nara T, Huang H. Protein kinase A regulatory subunit interacts with P-Type ATPases in Trypanosoma cruzi. Am J Trop Med Hyg 2009 80: 941-3. PMID: 19478254