研究業績 2004-2006年｜免疫学講座　順天堂大学医学部・大学院医学研究科

2006-2004年 研究業績

2019-　2018-2016　2015-2013　2012-2010　2009-2007　2003-2001　2000以前

1) Chiba A, Oki S, Miyamoto K, Hashimoto H, Yamamura T, Miyake S: Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of alpha-galactosylceramide. Arthritis Rheum 50:305-313, 2004

2) Oki S, Chiba A, Yamamura T and Miyake S: The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells. J Clin Invest 113:1631-1640, 2004

3) Takahashi T, Miyake S, Endoh M, Yamamura T: The regulatory role for natural killer cells in the "smoldering" state of multiple sclerosis. Brain 127:1917-1927, 2004

4) Mizuno M, Masumura M, Tomi C, Chiba S, Oki S, Yamamura T, Miyake S: Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J Autoimmun 23:293-300, 2004

5) Nakai Y, Iwabuchi K, Fujii S, Ishimori N, Dashtsoodol N, Watano K, Mishima T, Iwabuchi C, Kato K, Tanaka S, Bezbradica JS, Nakayama T, Tanigchi M, Miyake S, Yamamura T, Kitabatake A, Joyce S, Van Kaer L, Onoe K: Natural killer T cells accelerate atherogenesis in mice. Blood 104:2051-2059, 2004

6) Yamamura T, Miyamoto K, Illes Z, Pal E, Araki M, Miyake S: Synthetic glycolipids as potential therapeutics for autoimmune disease. Curr Topics Medic Chem 4:561-567, 2004

7) Miyake S, Chiba A, Yamamura T: Potential of targeting natural killer T cells for the treatment of autoimmune diseases. Mod Rheum. 14: 279-284, 2004

8) Bedoui S, Miyake S, Yamamura T: More sympathy for autoimmunity with neuropeptide Y? Trends Immunol 25:508-512, 2004

9) Satoh J-i, Nakanishi M, Koike F, Miyake S, Yamamuto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Kanda T, Fukazawa T, Yamamura T: Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Neurobiol Dis　18:537-550, 2005

10) Ueno Y., Tanaka S, Sumii M, Miyake S, Tazuma S, Taniguchi M, Yamamura T, Chayama K: Single dose of OCH improves mucosal Th1/Th2 cytokine balance and prevents experimental colitis in the presence of Vα14 NKT cells in mice. Inflamm Bowel Disease 11:35-41, 2005

11) Hashimoto D, Asakura S, Miyake S, Yamamura T, van Kaer L, Liu C, Tanimoto M, Teshima T: Stimulation of host natural killer T cells by synthetic glycolipid regulates acute graft-versus-host disease by inducint Th2 polarization of donor T cells. J Immunol 174:551-556, 2005

12) Murata K, Toba T, Nakanishi K, Takahashi B, Yamamura T, Miyake S, Annoura H: Total synthesis of an immunosuppressive glycolipid, (2S,3S,4R)-1-O- (alpha-d- galactosyl)-2-tetracosanoylamino-1,3,4-nonanetriol. J Org Chem 70:2398-2401, 2005

13) Yu KO, Im JS, Molano A, Dutronc Y, Illarionov PA, Forestier C, Fjiwara N, Arias I, Miyake S, Yamamur T, Chang YT, Besra GS, Porcellli SA: Modulation of CD1d-restricted NKT cell responses by using N-acylvariants of α-galactosylceramides. Proc Natl Acad Sci USA 102:3383-3388, 2005

14) Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K: IFN-γ-mediated negative feedback regulation of NKT cell function by CD94/NKG2. Blood 106:184-192, 2005

15) Chiba A, Kaieda S, Oki S, Yamamura T, Miyake S: The involvement of Vα14 NKT cells in the pathogenesis of murine models of arthritis. Arthritis Rheum 52:1941-1948, 2005

16) Toba T, Murata K, Yamamura T, Miyake S, Annoura H: A concise synthesis of (3S,4S,5R)-1-(α-D-galactopyranosyl)-3-tetracosanoylamino-4,5-decanediol, a C-glycoside analogue of immunomodulating α-galactosylceramide OCH. Tetrahedron Letters 46:5043-5047, 2005

17) Ronet C, Darche S, de Moraes ML, Miyake S, Yamamura T, Louis JA, Kasper LH, Buzoni-Gatel D: NKT cells are critical for the initiation of an inflammatory bowel response against Toxoplasma gondii. J Immunol 175: 899-908, 2005

18) Oki S, Tomi C, Yamamura T, Miyake S: Preferential Th2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production inflammatory cytokines by bystander cells in vivo. Int Immunol 17:1619-1629, 2005

19) Miyake S, Yamamura T: Therapeutic potential of gylcolipid ligands for natural killer (NK) T cells in the suppression of autoimmune diseases. Curr Drug Targets Immune Endo Meta Dis 5:315-322, 2005

20) Miyake S: Potential of targeting natural killer T cells for the treatment of autoimmune diseases. The innate immune system: Strategies for disease control Taniguchi M, Akira S, Nakayama T, eds, Elsevier, Amsterdam, 189-91 2005

21) Chiba A, Miyake S: NKT cells in models of arthritis. The immuno-regulatory role of natural killer T cells in inflammatory disease Croxford JL, eds, Signpost, Kerala, 71-85, 2005

22) Oki S, Miyake S: Molecular basis of differential cytokine production by glycolipid ligand-stimulated natural killer T (NKT) cells for therapeutic interventions for inflammatory autoimmune disease. The immuno-regulatory role of natural killer T cells in inflammatory disease Croxford JL, ed, Signpost, Kerala, 159-74, 2005

23) Pyz E, Naidenko O, Miyake S, Yamamura T, Berberich I, Cardell S, Kronenberg M, Herrmann T: The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR. J Immunol 176:7447-7455, 2006

24) Miyamoto K, Miyake S, Mizuno M, Oka N, Kusunoki S, Yamamura T: Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2 independent pathway. Brain 129:1984-1992, 2006

25) Croxford JL, Miyake S, Huang Y-Y, Shimamura M, Yamamura T: Invariant Vα19i T cells regulate autoimmune inflammation. Nat Immunol 7:987-994, 2006

26) Aranami T, Miyake S, Yamamura T: Differential expression of CD11c by peripheral blood NK cells reflects temporal activity of multiple sclerosis. J Immunol 177:5659-5667, 2006

27) Satoh J, Nakanishi M, Koike F, Onoue H, Aranami T, Ymamoto T, Kawai M, Kikuchi S, Nomura K, Yokoyama K, Ota K, Saito T, Ohta M, Miyake S, Kanda T, Fukazawa T, Yamamua T: T cell gene expression profiling identifies distinct subgroupus of Japanese multiple sclerosis patients. J Neuroimmunol 174:108-118, 2006

28) Miyake S: Invariant NKT cells in autoimmunity. Current Topics in Neuroimmunology Tabira T, Yamamura T, Kira J, eds, Medimond, Bologna, 91-5 2006