Juntendo University, Tokyo, established in 1838.


Department of Pathology and Oncology【Department of Molecular Pathogenesis】

 INTORODUCTION   RESEARCH   EDUCATION   FACULTY MEMBERS   PUBLICATIONS
 Japanese

PUBLICATIONS

2025

Original Research Publications
  1. Matsuda, S, Nakayama M, Do Y, Ishiuchi T, Yagi M, Wanrooij S, Nakada K, Wei F-Y, Ichiyanagi K, Sasaki H, Kang D, Yasukawa T* (2025) TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA. Communications Biology, 8(1): 202.
    Press release: (JP) https://www.juntendo.ac.jp/news/22031.html
    　　　　　　　(EN) https://en.juntendo.ac.jp/highlights/news/nid685
  2. Okazaki H, Mezawa Y, Shi Y, Sakimoto M, Wang Z, Ishizuka A, Yamashita K, Satoh A, Koyama Y, Fukumura Y, Kajino K, Takano A, Yokose T, Yamashita T, Miyagi Y, Daigo Y, Katakura A, Yasukawa T*, Orimo A* (2025) Expression of lymphoid enhancer-binding factor 1 in cancer-associated fibroblasts mediates tumor growth and transdifferentiation toward squamous cell carcinoma in human breast cancer. Cancer Med., 14(3): e70627.

　

2024

Original Research Publications
  1. Nakamura Y, Yasukawa T*, Fukumura Y, Takeda Y, Imamura H, Shi Y, Li M, Abe M, Uyama S, Kajino K, Ishijima M, Saiura A, Orimo A (2024) Association of stromal type IV collagen and prognosis in neoadjuvant chemotherapy-treated pancreatic cancer.  Jpn. J. Clin. Oncol.54(12):1261-1271.
Review articles
  1. Shirakihara T, Orimo A (2024) Activin A from primary breast tumors generates a pre-metastaticniche by inducing pulmonary fibrosis. Transl. Brest Cancer Res. 5:24.​
  2. Mezawa Y, Orimo A (2024) Carcinoma-associated fibroblast diversity and invasion- and metastasis-promoting mechanisms Experimental Medicine 11(42), 1664-1670. (in Japanese)

　

2023

Original Research Publications
  1. Mezawa Y, Wang T, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Yang  L, Maruyama R, Seimiya H, Orimo A* (2023) Glutamine deficiency drives TGF-β signaling activation that gives rise to myofibroblastic carcinoma-associated fibroblasts.Cancer Sci., 114(11):4376-4387.
    Press release : https://www.juntendo.ac.jp/news/15741.html
  2. Koyama Y, Okazaki H, Yang S, Mezawa Y, Wang Z, Sakimoto M, Ishizuka A, Ito Y, Koyama T, Daigo Y, Takano A, Miyagi Y, Yokose T, Yamashita T, Sugahara K, Hino O, Yang L, Maruyama R, Katakura A, Yasukawa T*, Orimo A* (2023) Increased RUNX3 expression mediates tumor-promoting ability of human breast cancer-associated fibroblasts. Cancer Med., 12(17):18062-18077.
  3. Vail ME, Farnsworth RH, Hii L, Allen S, Arora S, Anderson RL, Dickins RA, Orimo A, Wu SZ, Swarbrick A, Scott AM, Janes PW (2023) Inhibition of EphA3 expression in tumour stromal cells suppresses tumour growth and progression. Cancers (Basel) 15(18): 4646.
  4. Koyanagi A, Kajino K, Nojiri S, Abe M, Kobayashi T, Sugitani Y, Yue L, Ohtsuji N, Arakawa A, Sato T, Takahashi K, Suzuki K, Orimo A, Yao T, Hino O (2023) Serum levels of N- and C-ERC/Mesothelin and clinicopathological factors in mesothelioma patients and those without mesothelioma. Juntendo Medical Journal 69(2), 124-136.
  5. Fushimi T, Kobayashi T*, Itoh H (2023) CEP164-GLI2 association ensures the hedgehog signaling in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 666, 179-185.
  6. Sunaguchi T, Horikoshi Y, Hanaki T, Sakamoto T, Nakaso K, Sakai C, Yamashita K, Ohno S, Fujiwara Y, Matsura T. High Glucose-stimulated aPKC (2023) Activation Promotes Pancreatic Cancer Cell Progression Through YAP Signaling. Anticancer Res. 43(11), 4843-4853.
  7. Nishikawa K, Mezawa Y, Kobayashi T (2023) Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2-/- tumor cell line. Genes to Cells 28, 447-456.
Book chapter
  1. Yasukawa T*, Kang D (2023) Assessing TFAM Binding to Human Mitochondrial DNA.Methods in Molecular Biology. Vol. 2615, pp.139-151.

　

2022

Original Research Publications
  1. Tani H, Ishikawa K, Tamashiro H, Ogasawara, E, Yasukawa T, Matsuda, S, Shimizu A, Kang D, Hayashi JI, Wei FY, Nakada K (2022) Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation.Nucleic Acids Res. 50(16), 9382-9396.
  2. Taniguchi G, Kajino K, Momose S, Saeki H, Yue L, Ohtsuji N, Abe M, Shibuya T, Orimo A, Nagahara A, Watanabe S, Hino O (2022) The Inhibitory Effects of Anti-ERC/Mesothelin Antibody 22A31 on Colorectal Adenocarcinoma Cells, within a Mouse Xenograft Model. Cancers (Basel)28;14(9): 2198.
  3. Inatomi, T, Matsuda, S, Ishiuchi, T, Do Y, Nakayama, M, Abe S, Kasho K, Wanrooij S, Nakada, K, Ichiyanagi K, Sasaki H, Yasukawa T*, Kang D (2022) TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.Biochim. Biophys. Acta - Molecular Cell Research 1869(1): 119167.
  4. Nomiyama, T, Setoyama, D, Yasukawa T, Kang D (2022) Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication. J. Biochem. 171(3), 325-338.​
Review articles and book chapter
  1. Yasukawa T, Kang D (2022) Maintenance and Replication of mammalian mitochondrial DNA. Igaku no Ayumi 281(12), 1121-1127. (in Japanese)
  2. Mezawa Y, Orimo A (2022) The cellular differentiation program in carcinoma cells controlled by carcinoma-associated fibroblasts. Clinical immunology & Allergology, 144-151. (in Japanese)

　

2021

Original Research Publications
  1. Martínez-López A, García-Casas A, Bragado P, Orimo A, Castañeda-Saucedo E, Castillo-Lluva S (2021) Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumour development through IL-1β upregulation. Cancer Lett.521, 14-28.
  2. Iwai M, Tulafu M, Togo S, Kawaji H, Kadoya K, Namba Y, Jin J, Watanabe J, Okabe T, Hidayat M, Sumiyoshi I, Itoh M, Koyama Y, Ito Y, Orimo A, Takamochi K, Oh S, Suzuki K, Hayashizaki Y, Yoshida K, Takahashi K (2021) Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.Mol. Oncol. 15(5), 1507-1527.
Review articles
  1. Mezawa Y, Orimo A* （2021）Phenotypic heterogeneity, stability and plasticity in tumor-promoting carcinoma-associated fibroblasts. FEBS J.289(9), 2429-2447.
  2. Yasukawa T (2021) Replication and maintenance of mitochondrial genome Mitochondrial Dynamics Chapter 4: Part 3, pp. 121-129. (in Japanese)
  3. Tominaga K, Orimo A (2021) CAF heterogeneity and tumor-promoting action. Experimental Medicine 39, 55-60. (in Japanese)

　

2020

Original Research Publications
  1. Okabe T, Togo S, Fujimoto Y, Watanabe J, Sumiyoshi I,Orimo A, Takahashi K (2020) Mesenchymal Characteristics and Predictive Biomarkers on Circulating Tumor Cells for Therapeutic Strategy. Cancers (Basel), 12(12): 3588.
  2. Blanco-Gómez A, Hontecillas-Prieto L, Corchado-Cobos R, García-Sancha N, Salvador N, Castellanos-Martín A, Sáez-Freire MDM, Mendiburu-Eliçabe M, Alonso-López D, De Las Rivas J, Lorente M, García-Casas A, Del Carmen S, Abad-Hernández MDM, Cruz-Hernández JJ, Rodríguez-Sánchez CA, Claros-Ampuero J, García-Cenador B, García-Criado J,Orimo A, Gridley T, Pérez-Losada J, Castillo-Lluva S (2020) Stromal SNAI2 is required for ERBB2 breast cancer progression. Cancer Res. 80(23), 5216-5230.​
  3. Mizukoshi K, Okazawa Y, Haeno H,Koyama Y, Sulidan K, Komiyama H, Saeki H, Ohtsuji N, Ito Y, Kojima Y, Goto M, Habu S, Hino O, Sakamoto K*, Orimo A* (2020) Metastatic seeding of human colon cancer cell clusters expressing the hybrid epithelial/mesenchymal state. Int. J. Cancer, 146(9), 2547-2562.

　

~ 2019

Please refer to Research map URL of the individual members.

 INTORODUCTION   RESEARCH   EDUCATION   FACULTY MEMBERS   PUBLICATIONS
 Japanese
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