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■業績リスト（最近10年間）
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2023：
- Murwanti R, Denda-Nagai K, Sugiura D, Mogushi K, Gendler SJ, Irimura T. Prevention of inflammation-driven colon carcinogenesis in human MUC1 transgenic mice by vaccination with MUC1 DNA and dendritic cells. Cancers, 15 (6):1920, 2023. PMID: 36980805, doi: 10.3390/cancers15061920.
- Manome-Zenke Y, Denda-Nagai K, Murakami R, Noji M, Tsuneda N, Ishii-Schrade K, Kanomata N, Arai S, Irimura T, Ikeda S. Possible involvement of antigen presenting cells expressing the macrophage galactose-type C type lectin in inflammatory skin diseases. J Invest Dermatol, published online, 2023. PMID: 36963610, doi: 10.1016/j.jid.2023.03.1654.
- Semba R, Horimoto Y, Sakata-Matsuzawa M, Ishizuka Y, Denda-Nagai K, Fujihira H, Noji M, Onagi H, Ichida M, Miura H, Watanabe J, Saito M, Saito T, Arakawa A, Irimura T. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer. Sci Rep, 13(1):5281, 2023 .PMID: 37002293; doi: 10.1038/s41598-023-32579-4.
2022：
- Tian Y, Denda-Nagai K, Tsukui T, Ishii-Schrade K, Okada K, Nishizono Y, Matsuzaki K, Hafley M, Bresalier RS, Irimura T. Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner. Cell Death Discov, 8(1) 194, 2022. PMID: 35410995, doi: 10.1038/s41420-022-01006-4.
- Nishida J, Shichino S, Tsukui T, Hoshino M, Okada T, Okada K, Yi Y, Toraya-Brown S, Mochizuki M, Koizumi R, Ishii-Schrade K, Denda-Nagai K, Irimura T. Unique Glycoform-Dependent Monoclonal Antibodies for Mouse Mucin 21. int J Mol Sci, 2022;23(12). PMID: 35743163; doi: 10.3390/ijms23126718.
- Shi J, Kanoya R, Tani Y, Ishikawa S, Maeda R, Suzuki S, Kawanami F, Miyagawa N, Takahashi K, Oku T, Yamamoto A, Fukuzawa K, Nakajima M, Irimura T, Higashi N. Sulfated hyaluronan binds to heparanase and blocks Its enzymatic and cellular actions in carcinoma cells. Int J Mol Sci, 23(99): 5055, 2022. PMID: 35563446, doi: 10.3390/ijms23095055.
- Kokubu R, Ohno S, Kuratani H, Takahashi Y, Manabe N, Shimizu H, Chiba Y, Denda-Nagai K, Tsuiji M, Irimura T, Yamaguchi Y. O-Glycan-dependent interaction between MUC1 Glycopeptide and MY.1E12 antibody by NMR, molecular dynamics and docking simulations. Int J Mol Sci, 23(14): 7855, 2022. PMID: 35887202, doi: 10.3390/ijms23147855.
- Hlaing MT, Horimoto Y, Denda-Nagai K, Fujihira H, Noji M, Kaji H, Tomioka A, Ishizuka Y, Saeki H, Arakawa A, Saito M, Irimura T. Tamoxifen-resistant breast cancer cells exhibit reactivity with Wisteria floribunda agglutinin. Plos One 17(8): e0273513, 2022. PMID: 36006984, doi: 10.1371/journal.pone.0273513.
2021：
- Sakata-Matsuzawa M, Denda-Nagai K, Fujihira H, Noji M, Ishii-Schrade K, Matsuda A, Kuno A, Okazaki M, Nakai K, Horimoto Y, Saito M, Irimura T. Glycans unique to the relapse-prone subset within triple-negative breast cancer as revealed by lectin array-based analysis of surgical specimens. Plos One, 16(5): e0250747, 2021. PMID: 33974630, doi: 10.1371/journal.pone.0250747.
- Fujihira H, Takakura D, Matsuda A, Abe M, Miyazaki M, Nakagawa T, Kajino K, Denda-Nagai K, Noji M, Hino O, Irimura T. Bisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epithelioid mesothelioma cells. J Biochem, 170(3): 317-326, 2021. PMID: 33792699, doi: 10.1093/jb/mvab044.
- Okazaki M, Mogushi K, Denda-Nagai K, Fujihira H, Noji M, Ishii-Schrade K, Sakata-Matsuzawa M, Nakai K, Horimoto Y, Saito M, Irimura T. Biological and clinicopathological implications of beta-3-N-acetylglucosaminyltransferase 8 in triple-negative breast cancer. Anticancer Res, 2021 Feb;41(2):845-858, 2021. PMID: 33517290, doi: 10.21873/anticanres.14837.
- Kurashina R, Denda-Nagai K, Saba K, Hisai T, Hara H, Irimura T. Intestinal lamina propria macrophages upregulate interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a. Glycobiology, 31(7):827-837, 2021. PMID: 33677516, doi: 10.1093/glycob/cwab015.
- Tamada Y, Nomura H, Aoki D, Irimura T. A possible inhibitory role of sialic acid on MUC1 in peritoneal dissemination of clear cell-type ovarian cancer cells. Molecules, 26: 5962, 2021. PMID: 34641504, doi: 10.3390/molecules26195962.
2020：
- Higashi N, Irimura T, Nakajima M. Heparanase is involved in leukocyte migration. Adv Exp Med Biol, 1221:435-444, 2020. PMID: 32274720, doi: 10.1007/978-3-030-34521-1_16
2019：
- Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A. Clec10a regulates mite-induced dermatitis. Sci Immunol. 2019 Dec 6;4(42):eaax6908. doi: 10.1126/sciimmunol.aax6908.PMID: 31811054.
- Yoshimura Y, Denda-Nagai K, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, Noji M, Shichino S, Chiba Y, Irimura T. Products of chemoenzymatic synthesis representing MUC1 tandem repeat unit with T-, ST- or STn-antigen revealed distinct specificities of anti-MUC1 antibodies. Sci Rep. 2019 Nov 12;9(1):16641. doi: 10.1038/s41598-019-53052-1.
- Higashi N, Maeda R, Sesoko N, Isono M, Ishikawa S, Tani Y, Takahashi K, Oku T, Higashi K, Onishi S, Nakajima M, Irimura T. Chondroitin sulfate E blocks enzymatic action of heparanase and heparanase-induced cellular responses. Biochem Biophys Res Commun. 2019 Nov 26;520(1):152-158. doi: 10.1016/j.bbrc.2019.09.126.
- Yoshimoto T, Matsubara D, Soda M, Ueno T, Amano Y, Kihara A, Sakatani T, Nakano T, Shibano T, Endo S, Hagiwara K, Fukayama M, Denda-Nagai K, Irimura T, Mano H, Niki T. Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma. Cancer Sci. 2019 Sep;110(9):3006-3011. doi: 10.1111/cas.14129.
- Matsumura M, Okudela K, Nakashima Y, Mitsui H, Denda-Nagai K, Suzuki T, Arai H, Umeda S, Tateishi Y, Koike C, Kataoka T, Irimura T, Ohashi K. Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas - Implications for the progression of EGFR-mutated lung adenocarcinomas. PLoS One. 2019 Apr 11;14(4):e0215237. doi: 10.1371/journal.pone.0215237.
2018：
- Higashi N, Waki M, Sudo Y, Suzuki S, Oku T, Tsuiji M, Tsuji T, Miyagishi M, Takahashi K, Nakajima M, Irimura T. Incorporation, intracellular trafficking and processing of extracellular heparanase by mast cells: Involvement of syndecan-4-dependent pathway. Biochem Biophys Res Commun. 2018 Sep 18;503(4):3235-3241. doi: 10.1016/j.bbrc.2018.08.132.
- Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T. A critical domain of Ebolavirus envelope glycoprotein determines glycoform and infectivity. Sci Rep. 2018 Apr 3;8(1):5495. doi: 10.1038/s41598-018-23357-8.
- Adachi H, Nakae K, Sakamoto S, Nosaka C, Atsumi S, Shibuya M, Higashi N, Nakajima M, Irimura T, Nishimura Y. Microbial metabolites and derivatives targeted at inflammation and bone diseases therapy: chemistry, biological activity and pharmacology. J Antibiot (Tokyo). 2017 Nov 1. doi: 10.1038/ja.2017.138.
2017：
- Wu H, Tao A, Martin JD, Quader S, Liu X, Takahashi K, Hespel L, Miura Y, Hayakawa Y, Irimura T, Cabral H, Kataoka K. Proteasome Inhibitor-Loaded Micelles Enhance Antitumor Activity Through Macrophage Reprogramming by NF-κB Inhibition. J Pharm Sci. 2017 Apr 12. pii: S0022-3549(17)30217-4. doi: 10.1016/j.xphs.2017.03.031. [Epub ahead of print] PMID: 28412401
- Fujihira H, Masahara-Negishi Y, Tamura Y, Huang C, Harada Y, Wakana S, Takakura D, Kawasaki N, Taniguchi N, Kondoh G, Yamashita T, Funakoshi Y, Suzuki T. (2017) Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene. PLOS Genet. 2017 Apr 20;13(4):e1006696. doi: 10.1371/journal.pgen.1006696, PMID: 28426790
2016：
- Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y. IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression. Cancer Sci. 2016 Sep;107(9):1206-14. doi: 10.1111/cas.13005. Epub 2016 Sep 1. PMID: 27384869
- Sue M, Higashi N, Shida H, Kogane Y, Nishimura Y, Adachi H, Kolaczkowska E, Kepka M, Nakajima M, Irimura T. An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches.Int Immunopharmacol. 2016 Jun;35:15-21. doi: 10.1016/j.intimp.2016.03.017. Epub 2016 Mar 22. PMID: 27015605
- Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao R, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T. Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs. Cancer Sci. 2016 Feb;107(2):189-202. doi: 10.1111/cas.12857. Review. PMID: 26919617
- Tsunekawa N, Higashi N, Kogane Y, Waki M, Shida H, Nishimura Y, Adachi H, Nakajima M, Irimura T. Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines. Biochem Biophys Res Commun. 2016 Jan 22;469(4):878-83. doi: 10.1016/j.bbrc.2015.12.074. Epub 2015 Dec 20. PMID: 26713365
2015：
- Xin X, Akasaka-Manya K, Manya H, Furukawa J, Kuwahara N, Okada K, Tsumoto H, Higashi N, Kato R, Shinohara Y, Irimura T, Endo T. POMGNT1 Is Glycosylated by Mucin-Type O-Glycans. Biol Pharm Bull. 2015;38(9):1389-94. doi: 10.1248/bpb.b15-00415. PMID: 26328495
- Matsuda A, Kuno A, Nakagawa T, Ikehara Y, Irimura T, Yamamoto M, Nakanuma Y, Miyoshi E, Nakamori S, Nakanishi H, Viwatthanasittiphong C, Srivatanakul P, Miwa M, Shoda J, Narimatsu H. Lectin Microarray-Based Sero-Biomarker Verification Targeting Aberrant O-Linked Glycosylation on Mucin 1. Anal Chem. 2015 Jul 21;87(14):7274-81. doi: 10.1021/acs.analchem.5b01329. Epub 2015 Jul 7. PMID: 26091356
- Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T, Hayakawa Y. Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation. Cancer Sci. 2015 Jul;106(7):867-74. doi: 10.1111/cas.12685. Epub 2015 May 29. PMID: 25940224
2014：
- Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K. CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages. BMC Cancer. 2014 Dec 15;14:949. doi: 10.1186/1471-2407-14-949. PMID: 25495942
- Lou C, Takahashi K, Irimura T, Saiki I, Hayakawa Y. Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation. Int J Oncol. 2014 Nov;45(5):2085-91. doi: 10.3892/ijo.2014.2624. Epub 2014 Aug 27. PMID: 25175557
- Miyahara N, Shoda J, Kawamoto T, Ishida H, Ueda T, Akimoto Y, Kawakami H, Irimura T. Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications. Oncol Rep. 2014 Nov;32(5):1796-802. doi: 10.3892/or.2014.3443. Epub 2014 Aug 25. PMID: 25174601
- Kim SJ, Wang YG, Lee HW, Kang HG, La SH, Choi IJ, Irimura T, Ro JY, Bresalier RS, Chun KH. Up-regulation of neogenin-1 increases cell proliferation and motility in gastric cancer. Oncotarget. 2014 May 30;5(10):3386-98. PMID: 24930499
- Higashi N, Waki M, Sue M, Kogane Y, Shida H, Tsunekawa N, Hasan A, Sato T, Kitahara A, Kasaoka T, Hayakawa Y, Nakajima M, Irimura T. Heparanase-mediated cleavage of macromolecular heparin accelerates release of granular components of mast cells from extracellular matrices. Biochem J. 2014 Mar 1;458(2):291-9. doi: 10.1042/BJ20131463. PMID: 24344642
- Ng WC, Liong S, Tate MD, Irimura T, Denda-Nagai K, Brooks AG, Londrigan SL, Reading PC. The macrophage galactose-type lectin can function as an attachment and entry receptor for influenza virus. J Virol. 2014 Feb;88(3):1659-72. doi: 10.1128/JVI.02014-13. Epub 2013 Nov 20. PMID: 24257596
- Murakami R, Denda-Nagai K, Hashimoto S, Nagai S, Hattori M, Irimura T. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS One. 2013 Sep 9;8(9):e73270. doi: 10.1371/journal.pone.0073270. eCollection 2013. Erratum in: PLoS One. 2014;9(3):e93236. PMID: 24039898
2013：
- Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J. Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway. Cancer Lett. 2013 Oct 1;339(1):82-92. doi: 10.1016/j.canlet.2013.07.020. Epub 2013 Jul 20. PMID: 23879962
- Takahashi K, Takeda K, Saiki I, Irimura T, Hayakawa Y. Functional roles of tumor necrosis factor-related apoptosis-inducing ligand-DR5 interaction in B16F10 cells by activating the nuclear factor-κB pathway to induce metastatic potential. Cancer Sci. 2013 May;104(5):558-62. doi: 10.1111/cas.12112. Epub 2013 Feb 28. PMID: 23347256
特許リスト
- 入村 達郎、藤平 陽彦、伝田（永井） 香里、齊藤 光江、堀本 義哉、佐々木 律子、野地 美樹、鈴木 和宏、赤塚 淳一、小野 健一郎、西田 志陽、松浦 勝久、清水達也「抗ＨER２抗体及びこれを含有する医薬組成物」特願2021-42891（提出日令和3年3月16日）
- 入村 達郎、伝田（永井） 香里、野地 美樹、千葉 靖典、佐藤 隆、清水 弘樹、安型 清彦「シアリルＧａｌＮＡｃが結合したＭＵＣ１を認識する抗体」特願2023-011092 （提出日:令和 5年 1月27日）
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