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業績 |
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2024年
【英文原著論文】
- Yamatoya K, Kurosawa M, Hirose M, Miura Y, Taka H, Nakano T, Hasegawa A, Kagami K, Yoshitake H, Goto K, Ueno T, Fujiwara H, Shinkai Y, Frederick W K Kan, Ogura A, Araki Y. The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster. Biol Reprod. 2024 Mar 13;110(3):465-475. doi: 10.1093/biolre/ioad159.
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2023年
【英文原著論文】
- Yasuda H, Kaga N, Taka H, Ochiai T, Yamana T, Miura Y, Ishii M, Sasaki M, Ando J, Ando M. Polatuzumab vedotin pharmacokinetics in a hemodialysis patient with diffuse large B-cell lymphoma. Cancer Chemother Pharmacol. 2023 Sep 26. doi: 10.1007/s00280-023-04593-w. Online ahead of print. PMID: 37750932
- Kurusu R, Fujimoto Y, Morishita H, Noshiro D, Takada S, Yamano K, Tanaka H, Arai R, Kageyama S, Funakoshi T, Komatsu-Hirota S, Taka H, Kazuno S, Miura Y, Koike M, Wakai T, Waguri S, Noda NN, Komatsu M. Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex. Dev Cell. 2023 Jul 10;58(13):1189-1205.e11. doi: 10.1016/j.devcel.2023.04.015. Epub 2023 May 15. PMID: 37192622
- Kakehi S, Tamura Y, Ikeda SI, Kaga N, Taka H, Nishida Y, Kawamori R, Watada H. Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice. Front Physiol. 2023 Jun 14;14:1198390. doi: 10.3389/fphys.2023.1198390. eCollection 2023. PMID: 37389126 Free PMC article.
- Uchida T, Shimamura M, Taka H, Kaga N, Miura Y, Nishida Y, Nagayama Y, Watada H. The Effect of Long-Term Inorganic Iodine on Intrathyroidal Iodothyronine Content and Gene Expression in Mice with Graves' Hyperthyroidism. Thyroid. 2023 Mar;33(3):330-337. doi: 10.1089/thy.2022.0496. Epub 2023 Feb 1. PMID: 36565031 Free PMC article.
- Nihei Y, Haniuda K, Higashiyama M, Asami S, Iwasaki H, Fukao Y, Nakayama M, Suzuki H, Kikkawa M, Kazuno S, Miura Y, Suzuki Y, Kitamura D. Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy. Sci Adv. 2023 Mar 22;9(12):eadd6734. doi: 10.1126/sciadv.add6734. Epub 2023 Mar 22. PMID: 36947618 Free PMC article.
- Takamiya S, Nakamura T, Tsubokawa D, Tsuji N, Fukuda K, Yamasaki H, Fujimura T, Taka H, Kaga N, Kobayashi-Tanabe M, Matsuda M, Mita T. Biochemical characterization of mitochondria from adult worms and plerocercoid larvae of Spirometra mansoni shows mixed populations of anaerobic and aerobic mitochondria. Parasitol Int. 2023 Feb;92:102695. doi: 10.1016/j.parint.2022.102695. Epub 2022 Oct 29. PMID: 36349608
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2022年
【英文原著論文】
- Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun. 2022 Dec 21;13(1):7857. doi: 10.1038/s41467-022-35501-0. PMID: 36543799 Free PMC article.
- Sasazawa Y, Souma S, Furuya N, Miura Y, Kazuno S, Kakuta S, Suzuki A, Hashimoto R, Hirawake-Mogi H, Date Y, Imoto M, Ueno T, Kataura T, Korolchuk VI, Tsunemi T, Hattori N, Saiki S. Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2. EMBO J. 2022 Nov 17;41(22):e111476. doi: 10.15252/embj.2022111476. Epub 2022 Oct 11. PMID: 36394115 Free PMC article.
- Suzuki Y, Miyahara T, Jinnouchi M, Miura Y, Taka H, Kaga N, Ohara-Takada A. A Comprehensive Analysis of Plasma Cytokines and Metabolites Shows an Association between Galectin-9 and Changes in Peripheral Lymphocyte Subset Percentages Following Coix Seed Consumption. Nutrients. 2022 Apr 19;14(9):1696. doi: 10.3390/nu14091696. PMID: 35565664 Free PMC article.
- Sakai SS, Hasegawa A, Ishimura R, Tamura N, Kageyama S, Komatsu-Hirota S, Abe M, Ling Y, Okuda S, Funayama M, Kikkawa M, Miura Y, Sakimura K, Narita I, Waguri S, Shimizu R, Komatsu M. Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size. Mol Cell Biol. 2022 Jan 20;42(1):e0002421. doi: 10.1128/MCB.00024-21. Epub 2021 Nov 8. PMID: 34748402 Free PMC article.
- Morioka S, Nakanishi H, Yamamoto T, Hasegawa J, Tokuda E, Hikita T, Sakihara T, Kugii Y, Oneyama C, Yamazaki M, Suzuki A, Sasaki J, Sasaki T. A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation. Nat Commun. 2022 Jan 10;13(1):83. doi: 10.1038/s41467-021-27648-z. PMID: 35013169
- Hasegawa J, Tokuda E, Yao Y, Sasaki T, Inoki K, Weisman LS. PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity. Mol Biol Cell. 2022 Mar 1;33(3):ar26. doi: 10.1091/mbc.E21-06-0309. Epub 2022 Jan 12. PMID: 35020443
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2021年
【英文原著論文】
- Kakehi S, Tamura Y, Ikeda SI, Kaga N, Taka H, Ueno N, Shiuchi T, Kubota A, Sakuraba K, Kawamori R, Watada H. Short-term physical inactivity induces diacylglycerol accumulation and insulin resistance in muscle via lipin1 activation. Am J Physiol Endocrinol Metab. 2021 Dec 1;321(6):E766-E781. doi: 10.1152/ajpendo.00254.2020. Epub 2021 Nov 1. PMID: 34719943 Free article.
- Nakajima A, Shibuya T, Sasaki T, Lu YJ, Ishikawa D, Haga K, Takahashi M, Kaga N, Osada T, Sato N, Nagahara A. Nicotine Oral Administration Attenuates DSS-Induced Colitis Through Upregulation of Indole in the Distal Colon and Rectum in Mice. Front Med (Lausanne). 2021 Dec 13;8:789037. doi: 10.3389/fmed.2021.789037. eCollection 2021. PMID: 34966763 Free PMC article.
- Nakajima Y, Osaka S, Mizuno T, Yokoi K, Nakano S, Hirai S, Hiraoka Y, Miura Y, Suzuki M, Kusuhara H, Hayashi H. Influence of food on pharmacokinetics and pharmacodynamics of 4-phenylbutyrate in patients with urea cycle disorders. Mol Genet Metab Rep. 2021 Sep 4;29:100799. doi: 10.1016/j.ymgmr.2021.100799. eCollection 2021 Dec. PMID: 34522617 Free PMC article.
- Araki Y, Miura Y, Fujiwara H. Exploration of novel biomarkers for hypertensive disorders of pregnancy by comprehensive analysis of peptide fragments in blood: their potential and technologies supporting quantification. Clin Chem Lab Med. 2021 Oct 19. doi: 10.1515/cclm-2021-0713. Online ahead of print. PMID: 34664478
- Osaka S, Nakano S, Mizuno T, Hiraoka Y, Minowa K, Hirai S, Mizutani A, Sabu Y, Miura Y, Shimizu T, Kusuhara H, Suzuki M, Hayashi H. A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers. Mol Genet Metab. 2021 Apr;132(4):220-226. doi: 10.1016/j.ymgme.2021.02.002. Epub 2021 Feb 23. PMID: 33648834 Clinical Trial.
- Kazuno S, Fujimura T, Fujime M, Miura Y, Ueno T. O-glycosylated clusterin as a sensitive marker for diagnosing early stages of prostate cancer. Prostate. 2021 Feb;81(3):170-181. doi: 10.1002/pros.24094. Epub 2020 Dec 21. PMID: 33347638
- Hara T, Saeki K, Jinnouchi H, Kazuno S, Miura Y, Yokomizo T. The c-terminal region of BLT2 restricts its localization to the lateral membrane in a LIN7C-dependent manner. FASEB J. 2021 Feb;35(2):e21364. doi: 10.1096/fj.202002640R. PMID: 33481310
- Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, Eskelinen EL, Komatsu M. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nat Commun. 2021 Jan 4;12(1):16. doi: 10.1038/s41467-020-20185-1. PMID: 33397898 Free PMC article.
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2020年
【英文原著論文】
- Uzawa H, Kohno D, Koga T, Sasaki T, Fukunaka A, Okuno T, Jo-Watanabe A, Kazuno S, Miyatsuka T, Kitamura T, Fujitani Y, Watada H, Saeki K, Yokomizo T. Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis. FASEB J. 2020 Oct;34(10):13949-13958. doi: 10.1096/fj.202001148R. Epub 2020 Aug 26. PMID: 32844470
- Takewaki D, Suda W, Sato W, Takayasu L, Kumar N, Kimura K, Kaga N, Mizuno T, Miyake S, Hattori M, Yamamura T. Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22402-22412. doi: 10.1073/pnas.2011703117. Epub 2020 Aug 24. PMID: 32839304 Free PMC article.
- Saito K, Murayama T, Hata T, Kobayashi T, Shibata K, Kazuno S, Fujimura T, Sakurai T, Toyoshima YY. Conformational diversity of dynactin sidearm and domain organization of its subunit p150. Mol Biol Cell. 2020 Jun 1;31(12):1218-1231. doi: 10.1091/mbc.E20-01-0031. Epub 2020 Apr 2. PMID: 32238103 Free PMC article.
- Shoji H, Taka H, Kaga N, Ikeda N, Hisata K, Miura Y, Shimizu T. Choline-related metabolites influenced by feeding patterns in preterm and term infants. J Matern Fetal Neonatal Med. 2020 Jan;33(2):230-235. doi: 10.1080/14767058.2018.1488165. Epub 2018 Jul 22. PMID: 29886808
【英文総説】
- Ueno T, Komatsu M. Monitoring Autophagy Flux and Activity: Principles and Applications. Bioessays. 2020 Nov;42(11):e2000122. doi: 10.1002/bies.202000122. Epub 2020 Aug 26. PMID: 32851706
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2019年
【英文原著論文】
- Oda-Sakurai R, Yoshitake H, Miura Y, Kazuno S, Ueno T, Hasegawa A, Yamatoya K, Takamori K, Itakura A, Fujiwara H, Takeda S, Araki Y. NUP62: the target of an anti-sperm auto-monoclonal antibody during testicular development. Reproduction. 2019 Dec;158(6):503-516. doi: 10.1530/REP-19-0333. PMID: 31585439
- Kitagawa R, Kon K, Uchiyama A, Arai K, Yamashina S, Kuwahara-Arai K, Kirikae T, Ueno T, Ikejima K. Rifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature. Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G707-G715. doi: 10.1152/ajpgi.00372.2018. Epub 2019 Sep 11. PMID: 31509430 Free article.
- Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y.Correction: Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. Oncotarget. 2019 Nov 26;10(63):6842. doi: 10.18632/oncotarget.27309. eCollection 2019 Nov 26. PMID: 31827726 Free PMC article.
- Nakamura K, Ikeuchi T, Nara K, Rhodes CS, Zhang P, Chiba Y, Kazuno S, Miura Y, Ago T, Arikawa-Hirasawa E, Mukouyama YS, Yamada Y. Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier. J Cell Biol. 2019 Oct 7;218(10):3506-3525. doi: 10.1083/jcb.201807178. Epub 2019 Sep 20. PMID: 31541017 Free PMC article.
- Suehara Y, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Sano K, Hasegawa N, Miura Y, Akaike K, Kim Y, Takamochi K, Takahashi F, Ueno T, Kaneko K, Saito T. Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone. Proteomics Clin Appl. 2019 Sep;13(5):e1800147. doi: 10.1002/prca.201800147. Epub 2019 Jul 22. PMID: 31287244
- Saiki S, Sasazawa Y, Fujimaki M, Kamagata K, Kaga N, Taka H, Li Y, Souma S, Hatano T, Imamichi Y, Furuya N, Mori A, Oji Y, Ueno SI, Nojiri S, Miura Y, Ueno T, Funayama M, Aoki S, Hattori N. A metabolic profile of polyamines in parkinson disease: A promising biomarker. Ann Neurol. 2019 Aug;86(2):251-263. doi: 10.1002/ana.25516. Epub 2019 Jul 1. PMID: 31155745 Free PMC article.
- Sato T, Yamashina S, Izumi K, Ueno T, Koike M, Ikejima K, Peters C, Watanabe S. Cathepsin L-deficiency enhances liver regeneration after partial hepatectomy. Life Sci. 2019 Mar 15;221:293-300. doi: 10.1016/j.lfs.2019.02.040. Epub 2019 Feb 20. PMID: 30797017
- Suzuki M, Kon K, Ikejima K, Arai K, Uchiyama A, Aoyama T, Yamashina S, Ueno T, Watanabe S. The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-Ay Mice. Alcohol Clin Exp Res. 2019 Apr;43(4):617-627. doi: 10.1111/acer.13982. Epub 2019 Mar 7. PMID: 30748014
- Nitta A, Hori K, Tanida I, Igarashi A, Deyama Y, Ueno T, Kominami E, Sugai M, Aoki K. Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S. Biochem Biophys Res Commun. 2019 Jan 8;508(2):521-526. doi: 10.1016/j.bbrc.2018.11.158. Epub 2018 Nov 30. PMID: 30503495
- Kishimoto M, Suenaga J, Takase H, Araki K, Yao T, Fujimura T, Murayama K, Okumura K, Ueno R, Shimizu N, Kawahara N, Yamamoto T, Seko Y. Oxidative stress-responsive apoptosis inducing protein (ORAIP) plays a critical role in cerebral ischemia/reperfusion injury. Sci Rep. 2019 Sep 18;9(1):13512.
- Hasegawa J, Jebri I, Yamamoto H, Tsujita K, Tokuda E, Shibata H, Maki M, Itoh T. SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor. J Cell Sci. 2019 Oct 3;132(19):jcs229179. doi: 10.1242/jcs.229179. PMID: 31492760
【英文総説】
- Ueno T, Komatsu M. Measuring Nonselective and Selective Autophagy in the Liver. Methods Mol Biol. 2019;1880:535-540. doi: 10.1007/978-1-4939-8873-0_34. PMID: 30610720
【学会発表】
- 高宮 信三郎, 數野 彩子, 三浦 芳樹, 美田 敏宏. ブタ回虫Ascaris suumミトコンドリアの比較プロテオーム解析にむけて: 線虫ミトコンドリアの高純度調製. 第88回日本寄生虫学会大会, 長崎大学坂本キャンパス, 長崎, 2019年3月15-16日
- 岩本 亮介, 奈良 武司, 坂口 美亜子, 數野 彩子, 牧内 貴志, 上野 隆, 三浦 芳樹, 橋本 哲男. フォルニカータ鞭毛虫Kipferlia bialataのミトコンドリア関連オルガネラのプロテオーム解析―寄生適応に伴うミトコンドリア進化の理解を目指して―. 第88回日本寄生虫学会大会, 長崎大学坂本キャンパス, 長崎, 2019年3月15-16日
- 加賀 直子, 高 ひかり, 上野 隆, 三浦 芳樹. 出生後母乳を介したメチルドナー補充が低栄養出生仔へ与える影響. 第92回日本生化学会大会, パシフィコ横浜, 横浜, 2019年9月19日
- 上野 隆,數野 彩子 , 平岡 由佳, 三浦 芳樹. リソソーム β-アラニンの代謝的意義. 第92回日本生化学会大会, パシフィコ横浜, 横浜, 2019年9月20日
- 緒方洵, 上野 紀子, 柴-福嶋 佳保里, 井下 強, 三浦 芳樹, 今居 譲, 服部 信孝. パーキンソン病関連分子 VPS13 は脂質代謝に関与する. 第42回分子生物学会年会, 福岡国際会議場 マリンメッセ福岡, 福岡, 2019年12月3日
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2018年
【英文原著論文】
- Sekihara K, Saitoh K, Yang H, Kawashima H, Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Niyonsaba F, Sasai K, Tabe Y. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLoS One. 2018 Jun 18;13(6):e0199117. doi: 10.1371/journal.pone.0199117. eCollection 2018. PMID: 29912936 Free PMC article.
- Akaike K, Suehara Y, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Toda-Ishii M, Kurihara T, Kim Y, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T. PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. Oncotarget. 2018 May 18;9(38):25206-25215. doi: 10.18632/oncotarget.25392. eCollection 2018 May 18. PMID: 29861864 Free PMC article.
- Horimoto Y, Tanabe M, Kazuno S, Miura Y, Mogushi K, Sonoue H, Arakawa A, Kajino K, Kobayashi T, Saito M. Elucidation of inhibitory effects on metastatic sentinel lymph nodes of breast cancer during One-Step Nucleic Acid Amplification. Sci Rep. 2018 May 15;8(1):7563. doi: 10.1038/s41598-018-25911-w. PMID: 29765119 Free PMC article.
- Asao R, Seki T, Takagi M, Yamada H, Kodama F, Hosoe-Nagai Y, Tanaka E, Trejo JAO, Yamamoto-Nonaka K, Sasaki Y, Hidaka T, Ueno T, Yanagita M, Suzuki Y, Tomino Y, Asanuma K. Rac1 in podocytes promotes glomerular repair and limits the formation of sclerosis. Sci Rep. 2018 Mar 22;8(1):5061. doi: 10.1038/s41598-018-23278-6. PMID: 29567961 Free PMC article.
- Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T. IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma. Oncotarget. 2018 Feb 12;9(18):14428-14443. doi: 10.18632/oncotarget.24467. eCollection 2018 Mar 6. PMID: 29581854 Free PMC article.
- Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N. Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease. Neurology. 2018 Jan 30;90(5):e404-e411. doi: 10.1212/WNL.0000000000004888. Epub 2018 Jan 3. PMID: 29298852 Free PMC article.
- Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N. NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy. EMBO Rep. 2018 Dec;19(12):e46363. doi: 10.15252/embr.201846363. Epub 2018 Oct 11.
- Tabe Y, Saitoh K, Yang H, Sekihara K, Yamatani K, Ruvolo V, Taka H, Kaga N, Kikkawa M, Arai H, Miida T, Andreeff M, Spagnuolo PA, Konopleva M. Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine. Sci Rep. 2018 Nov 15;8(1):16837. doi: 10.1038/s41598-018-35198-6.
- Ishii M, Suehara Y, Sano K, Kohsaka S, Hayashi T, Kazuno S, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T. Proteomic signatures corresponding to the SS18/SSX fusion gene in synovial sarcoma. Oncotarget. 2018 Dec 25;9(101):37509-37519
【学会発表】
- 小田 理沙子, 吉武 洋, 數野 彩子, 三浦 芳樹, 上野 隆, 櫻庭 真弓, 髙森 建二, 長谷川 昭子, 藤原 浩, 竹田 省, 荒木 慶彦. CD73 as a candidate glycoprotein for a target of a mouse anti-sperm auto-monoclonal antibody, Ts4, which recognizes a bisecting GlcNAc structure in the testicular germ cells. 第33回日本生殖免疫学会総会・学術集会,日本医科大学, 東京, 2018年11月24日
- 藤村 務, 大野 賢一, 數野 彩子, 上野 隆, 蓬田 伸. K562細胞におけるセサモールの抗腫瘍効果に関する構造活性. 第91回日本生化学会大会, 京都国際会館, 京都, 2018年9月26日
- 岩本 亮介, 奈良 武司, 坂口 美亜子, 牧内 貴志, 三浦 芳樹, 上野 隆, 橋本 哲男. 自由生活性フォルニカータ鞭毛虫Kipferlia bialataのミトコンドリア関連オルガネラの精製とプロテオーム解析. 第26回分子寄生虫学ワークショップ／第16回分子寄生虫・マラリア研究フォーラム合同大会, 松山, 2018年9月
- 中野 聡, 林 久允, 大坂 周平, 箕輪 圭, 平岡 由佳, 三浦 芳樹, 鈴木 光幸, 清水 俊明. 尿素サイクル異常症に対するフェニル酪酸ナトリウムの至適用法・用量を探索するための臨床研究. 第45回日本小児栄養消化器肝臓学会, 大宮ソニックシティ, 埼玉, 2018年10月6日
- 高 ひかり, 加賀 直子, 上野 隆, 三浦 芳樹, 根本 崇宏. 低出生体重仔への高脂肪食負荷による非感染性慢性疾患(NCDs)発症リスクへの影響. 第91回日本生化学会大会, 京都国際会館, 京都, 2018年9月
【産業財産権】
- 服部 信孝, 斉木 臣二, 波田野 琢, 吉川 有紀子, 青木 茂樹, 鎌形 康司, 三浦 芳樹, 高 ひかり, 加賀 直子, 戸田 達史, 佐竹 渉. パーキンソン病の重症度判定方法. 公開番号(公開出願番号):特開2018-072103
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2017年
【英文原著論文】
- Sasaki Y, Hidaka T, Ueno T, Akiba-Takagi M, Trejo JA, Seki T, Nagai-Hosoe Y, Tanaka E, Horikoshi S, Tomino Y, Suzuki Y, Asanuma K. Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte. Sci Rep. 7:43921, 2017.
- Hosoe-Nagai Y, Hidaka T, Sonoda A, Sasaki Y, Yamamoto-Nonaka K, Seki T, Asao R, Tanaka E, Trejo JAO, Kodama F, Takagi M, Tada N,Ueno T , Nishinakamura R, Tomino Y, Asanuma K. Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis. Lab Invest. 97:1306-1320, 2017.
- Shigiyama F, Kumashiro N, Furukawa Y, Funayama T, Takeno K, Wakui N, Ikehara T, Nagai H, Taka H, Fujimura T, Uchino H, Tamura Y, Watada H, Nemoto T, Shiraga N, Sumino Y, Hirose T. Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease. Hepatol Commun. 29;1(7):634-647, 2017.
- Shoji H, Taka H, Kaga N, Ikeda N, Kitamura T, Miura Y, Shimizu T. A pilot study of the effect of human breast milk on urinary metabolome analysis in infants. J Pediatr Endocrinol Metab. 28;30(9):939-946, 2017.
- Sekihara K, Saitoh K, Han L, Ciurea S, Yamamoto S, Kikkawa M, Kazuno S, Taka H, Kaga N, Arai H, Miida T, Andreeff M, Konopleva M, Tabe Y. Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1. Oncotarget. 23;8(21):34552-34564, 2017.
- Namba Y, Togo S, Tulafu M, Kadoya K, Nagahama KY, Taka H, Kaga N, Orimo A, Liu X, Takahashi K. Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes. Respir Res. 11;18(1):46, 2017.
- Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice. J Immunol. 199(10):3516-3524, 2017.
- Mizuno M, Noto D, Kaga N, Chiba A, Miyake S. The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models. PLoS One. 12(2): e0173032. 2017.
- Jurjevic I, Miyajima M, Ogino I, Akiba C, Nakajima M, Kondo A, Kikkawa M, Kanai M, Hattori N, Arai H. Decreased Expression of hsa-miR-4274 in Cerebrospinal Fluid of Normal Pressure Hydrocephalus Mimics with Parkinsonian Syndromes. J Alzheimers Dis. 56(1):317-325. 2017.
- Kakuta S, Yamaguchi J, Suzuki C, Sasaki M, Kazuno S, Uchiyama Y. Small GTPase Rab1B is associated with ATG9A vesicles and regulates autophagosome formation. FASEB J. 31(9):3757-3773. 2017.
- Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo V, Ishizawa J, Hail N Jr, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M. Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. Cancer Res. 77(6):1453-1464. 2017.
- Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, Ohkawa Y, Yokomizo T. Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. PLoS ONE. 12(9):e0185133, 2017.
【英文総説】
- Ueno T, Komatsu M. Autophagy in the liver: functions in health and disease. Nat Rev Gastroenterol Hepatol. 14:170-184, 2017.
- Tanida I, Ueno T, Uchiyama Y. Use of pHlurorin-mKate2-human LC3 to Monitor Autophagic Responses. Methods Enzymol. 587:87-96, 2017.
【和文著作】
- 梶山 美明, 三浦 芳樹,藤村 務 . 食道がん患者の呼気に含まれる特定物質, 生体ガス計測と高感度ガスセンシング, 三林浩二（編）, 東京都（日本）；シーエムシー出版, 2017；57-62
【学会発表】
- Ueno T, Kazuno S, Hiraoka Y, Miura Y. Comprehensive analyses to idetify specific marker(s) for autophagic degradation. 第3回国際スポートロジー学会, 順天堂大学, 東京, 平成29年10月
- Miura Y, Kazuno S, Taka H, Ueno T. Profiling of Histidine Phosphorylation in C2C12 Mouse Myoblast Cell Line. 第3回国際スポートロジー学会, 順天堂大学, 東京, 平成29年10月
- 高宮 信三郎, 數野 彩子, 峯木 礼子, 三浦 芳樹, 美田 敏宏. 回虫成虫筋ミトコンドリアのプロテオーム解析:自活性線虫との比較. 第11回蠕虫研究会, やすらぎ伊王島, 長崎, 平成 29年 9月
- 數野 彩子, 藤村 務, 三浦 芳樹, 上野 隆. 前立腺がん特異的糖鎖構造変化を呈するキャリア糖タンパク質解析. 2017年度生命科学系学会合同年次大会（ConBio2017）, 神戸国際会議場, 神戸, 平成29年12月
- 谷田 以誠, 上野 隆, 小池 正人. ペキソファジー高感度可視化方法の分子基盤の確立. 2017年度生命科学系学会合同年次大会（ConBio2017）, 神戸国際会議場, 神戸, 平成29年12月
- 蓬田 伸, 染谷 明正, 數野 彩子, 上野 隆, 三浦 芳樹, 菅野 秀一, 冨澤 亜也子, 原 明義, 藤村 務. Doxorubicin耐性細胞における Keap1-Nrf2 pathwayの役割. 2017年度生命科学系学会合同年次大会（ConBio2017）, 神戸国際会議場, 神戸, 平成29年12月
- 藤村 務, 數野 彩子, 三浦 芳樹, 上野 隆, 蓬田 伸. ゴマリグナン類のK562細胞に対する抗腫瘍効果の検討. 2017年度生命科学系学会合同年次大会（ConBio2017）, 神戸国際会議場, 神戸, 平成29年12月
- 高宮 信三郎, 數野 彩子, 峯木 礼子, 三浦 芳樹, 美田 敏宏. 線虫ミトコンドリアのプロテオーム解析：二次元電気泳動法とショットガン質量分析. 2017年度生命科学系学会合同年次大会（ConBio2017）, 神戸国際会議場, 神戸, 平成29年12月
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2016年
【英文原著論文】
- Morales J, Hashimoto M, Williams TA, Hirawake-Mogi H, Makiuchi T, Tsubouchi A, Kaga N, Taka H, Fujimura T, Koike M, Mita T, Bringaud F, Concepcion JL, Hashimoto T, Embley TM, Nara T. Differential remodelling of peroxisome function underpins the environmental and metabolic adaptability of diplonemids and kinetoplastids. Proc Biol Sci. 283(1830), 2016.
- Mukaihara K, Suehara Y, Kohsaka S, Akaike K, Tanabe Y, Kubota D, Ishii M, Fujimura T, Kazuno S, Okubo T, Takagi T, Yao T, Kaneko K, Saito T. Protein Expression Profiling of Giant Cell Tumors of Bone Treated with Denosumab. PLoS One. 11(2):e0148401, 2016.
- Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2. J Clin Endocrinol Metab. 101(10):3676-3684, 2016.
- Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M. Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces. Nat Chem Biol. 11:967-972. 2016.
- Miyamae Y, Mochizuki S, Shimoda M, Ohara K, Abe H, Yamashita S, Kazuno S, Ohtsuka T, Ochiai H, Kitagawa Y, Okada Y. ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death. FEBS J. 283(9):1574-94, 2016.
- Kazuno S, Furukawa J, Shinohara Y, Murayama K, Fujime M, Ueno T, Fujimura T. Glycosylation status of serum immunoglobulin G in patients with prostate diseases. Cancer Med. 5(6):1137-46, 2016.
- Tabe Y, Hatanaka Y, Nakashiro M, Sekihara K, Yamamoto S, Matsushita H, Kazuno S, Fujimura T, Ikegami T, Nakanaga K, Matsumoto H, Ueno T, Aoki J, Yokomizo T, Konopleva M, Andreeff M, Miida T, Iwabuchi K, Sasai K. Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells. Int J Radiat Biol. 92(1):24-34, 2016.
- Gunji-Niitsu Y, Kumasaka T, Kitamura S, Hoshika Y, Hayashi T, Tokuda H, Morita R, Kobayashi E, Mitani K, Kikkawa M, Takahashi K, Seyama K. Benign clear cell "sugar" tumor of the lung in a patient with Birt-Hogg-Dube syndrome: a case report. BMC Med. Genet. 17(1):85, 2016.
- Hoshika Y, Takahashi F, Togo S, Hashimoto M, Nara T, Kobayashi T, Nurwidya F, Kataoka H, Kurihara M, Kobayashi E, Ebana H, Kikkawa M, Ando K, Nishino K, Hino O, Takahashi K, Seyama K. Haploinsufficiency of the folliculin gene leads to impaired functions of lung fibroblasts in patients with Birt-Hogg-Dube syndrome. Physiol. Rep. 4(21). pii: e13025, 2016.
- Ijuin T, Takeuchi Y, Shimono Y, Fukumoto M, Tokuda E, Takenawa T. Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer. Cancer Sci. 2016 Jul;107(7):981-90. doi: 10.1111/cas.12968. Epub 2016 Jun 24.
PMID: 27178239
【学会発表】
- 數野 彩子, 藤村 務, 上野 隆. レクチンを活用した前立腺がん特異的糖鎖構造変化およびキャリア糖タンパク質の同定. 第89回 日本生化学会大会, 仙台国際センター, 仙台, 平成28年9月
- 赤池 慶祐, 末原 義之, 高阪 真路, 石井 翠, 窪田 大介, 田邊 雄, 峯木 礼子, 數野 彩子, 金子 和夫, 八尾 隆史, 齋藤 剛. 胞巣型横紋筋肉腫のタンパク質発現解析： PP2A パスウエイの腫瘍増殖能の検討. 第75回日本癌学会学術総会, パシフィコ横浜, 横浜, 平成28年10月
- 田邊 雄, 末原 義之, 高阪 真路, 向井原 健太, 赤池 慶祐, 石井 翠, 窪田 大介, 數野 彩子, 峯木 礼子, 金子 和夫, ラダーニー・マーク, 齋藤 剛. ユーイング肉腫のタンパク質発現解析：IRE1α/XBP1 パスウエイの腫瘍増殖能の検討. 第75回日本癌学会学術総会, パシフィコ横浜, 横浜, 平成28年10月
- 加賀 直子, 高 ひかり, 上野 隆, 根本 崇宏. 低出生体重仔における非感染性慢性疾患発症機序の解明. 第10回メタボロームシンポジウム, 鶴岡メタボロームキャンパス, 山形県鶴岡市, 平成28年10月
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各研究分野紹介一覧