教室紹介、スタッフ紹介、研究、業績等、順天堂大学大学院 共同研究・研修室に関する様々な情報をご案内します。

2021年

1. Defined serum-free culture of human infant small intestinal organoids with predetermined doses of Wnt3a and R-spondin1 from surgical specimens.
   Matsumoto Y, Koga H, Takahashi M, Suda K, Ochi T, Seo S, Miyano G, Miyake Y, Nakajima H, Yoshida S, Mikami T, Okazaki T, Hattori N, Yamataka A, Nakamura T.
   Pediatr Surg Int. (2021) Epub ahead of print.
2. Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus.
   Tsuyama S, Kohsaka S, Hayashi T, Suehara Y, Hashimoto T, Kajiyama Y, Tsurumaru M, Ueno T, Mano H, Yao T, Saito T.
   Histopathology (2021) 78, 240-251.

2020年

1. A homozygous variant in NDUFA8 is associated with developmental delay, microcephaly, and epilepsy due to mitochondrial complex I deficiency.
   Yatsuka Y, Kishita Y, Formosa LE, Shimura M, Nozaki F, Fujii T, Nitta KR, Ohtake A, Murayama K, Ryan MT, Okazaki Y.
   Clin Genet. (2020) 98, 155-165.
2. Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells.
   Han B, Lee-Okada HC, Ishimine M, Orita H, Nishikawa K, Takagaki T, Kajino K, Yokomizo T, Hino O, Kobayashi T.
   FEBS Open Bio. (2020) 10, 2375-2387.
3. The origin identification method for crude drugs derived from arthropods and annelids using molecular biological techniques.
   Nakanishi H, Yoneyama K, Hara M, Takada A, Saito K.
   J. Nat. Med. (2020) 74, 275-281.
4. Novel missense mutation (A414P) in ATP2C1 in a case of familial Hailey-Hailey disease.
   Kaga-Kamijo M, Ikeda S.
   J. Dermatol. (2020) 47, e289-e291.
5. A Soluble Fiber Diet Increases Bacteroides fragilis Group Abundance and Immunoglobulin A Production in the Gut.
   Nakajima A, Sasaki T, Itoh K, Kitahara T, Takema Y, Hiramatsu K, Ishikawa D, Shibuya T, Kobayashi O, Osada T, Watanabe S, Nagahara A.
   Appl. Environ. Microbiol. (2020) 86, e00405-20.
6. NAD(P)HX dehydratase protein-truncating mutations are associated with neurodevelopmental disorder exacerbated by acute illness.
   Borna NN, Kishita Y, Abe J, Furukawa T, Ogawa-Tominaga M, Fushimi T, Imai-Okazaki A, Takeda A, Ohtake A, Murayama K, Okazaki Y.
   Brain (2020) 143, e54.
7. Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface.
   Masubuchi N, Araki M, Yang Y, Hayashi E, Imai M, Edahiro Y, Hironaka Y, Mizukami Y, Kihara Y, Takei H, Nudejima M, Koike M, Ohsaka A, Komatsu N.
   Leukemia (2020) 34, 499?509.
8. Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice.
   Kadoguchi T, Shimada K, Miyazaki T, Kitamura K, Kunimoto M, Aikawa T, Sugita Y, Ouchi S, Shiozawa T, Yokoyama-Nishitani M, Fukao K, Miyosawa K, Isoda K, Daida H.
   Geriatr Gerontol Int. (2020) 20, 78-84.

2019年

1. Establishment of widely applicable DNA extraction methods to identify the origins of crude drugs derived from animals using molecular techniques.
   Nakanishi H, Yoneyama K, Hayashizaki Y, Hara M, Takada A, Saito K.
   J. Nat. Med. (2019) 73, 173-178.
2. Bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB p65 phosphorylation in senescent endothelial cells.
   Suzuki K, Ohkuma M, Nagaoka I.
   Int. J. Mol. Med. (2019) 44, 1187-1196.
3. Molecular and clinicopathological analyses of esophageal carcinosarcoma with special reference to morphological change.
   Tsuyama S, Saito T, Akazawa Y, Yanai Y, Yatagai N, Akaike K, Hayashi T, Suehara T, Takahashi F, Takamochi K, Hashimoto T, Kajiyama Y, Tsurumaru M, Fukunaga T, Yao T.
   Virchows Arch. (2019) 475, 415-424.
4. Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation.
   Araki M, Yang Y, Imai M, Mizukami Y, Kihara Y, Sunami Y, Masubuchi N, Edahiro Y, Hironaka Y, Osaga S, Ohsaka A, Komatsu N.
   Leukemia (2019) 33, 122?131.
5. Histological and Transmission Electron Microscopy Results after Embolization with HydroSoft/HydroFrame Coils in Experimental Swine Aneurysm.
   Iseki S, Mitome-Mishima Y, Ogino I, Suga Y, Yatomi K, Nonaka S, Miyamoto N, Kondo A, Yamamoto M, Arai H, Oishi H.
   BioMed. Res. Int. (2019) Article ID 4834535.
6. Resveratrol inhibits decidualization by accelerating downregulation of the CRABP2-RAR pathway in differentiating human endometrial stromal cells.
   Ochiai A, Kuroda K, Ozaki R, Ikemoto Y, Murakami K, Muter J, Matsumoto A, Itakura A, Brosens JJ, Takeda S.
   Cell. Death. Dis. (2019) 10, Article number: 276.
7. The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-A(y) Mice.
   Suzuki M, Kon K, Ikejima K., Arai K, Uchiyama A, Aoyama T, Yamashina S, Ueno T, Watanabe S.
   Alcohol. Clin. Exp. Res. (2019) 43, 617-627.
8. Establishment of widely applicable DNA extraction methods to identify the origins of crude drugs derived from animals using molecular techniques.
   Nakanishi H, Yoneyama K, Hayashizaki Y, Hara M, Takada A, Saito K.
   J. Nat. Med. (2019) 73, 173?178.
9. Usefulness of immunohistochemistry for mismatch repair protein and microsatellite instability examination in adenocarcinoma and background endometrium of sporadic endometrial cancer cases. Saeki H, Hlaing MT, Horimoto Y, Kajino K, Ohtsuji N, Fujino K, Terao Y, Hino O.
   J. Obstet. Gynaecol. Res. (2019) 45, 2037-2042.
10. Unique primed status of microglia under the systemic autoimmune condition of lupus-prone mice.
    Nomura A, Noto D, Murayama G, Chiba A, Miyake S.
    Arthritis. Res. Ther. (2019) 21, Article number: 303.
11. Rifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature.
    Kitagawa R, Kon K, Uchiyama A, Arai K, Yamashina S, Kuwahara-Arai K, Kirikae T, Ueno T, Ikejima K.
    Am. J. Physiol. Gastrointest. Liver. Physiol. (2019) 317, G707-G715
12. Comparison of magnetization transfer contrast of conventional and simultaneous multislice turbo spin echo acquisitions focusing on excitation time interval.
    Murata S, Tachibana Y, Murata K, Kamagata K, Hori M, Andica C, Suzuki M, Wada A, Kumamaru K, Hagiwara A, Irie R, Sato S, Hamasaki N, Fukunaga I, Hoshito H, Aoki S.
    Jpn. J. Radiol. (2019) 37, 579-589.
13. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea.
    Miotto O, Sekihara M, Tachibana S-I, Yamauchi M, Pearson RD, Amato R, Goncalves S, Somya M, Noviyanti R, Marfurt J, Auburn S, Price RN, Mueller I, Ikeda M, Mori T, Hirai M, Tavul L, Hetzel M, Laman M, Barry A, Ringwald P, Ohashi J, Hombhanje F, Kwiatkowski DP, Mita T.
    bioRxiv. (2019)

2018年

1. The relationship between TP53 gene status and carboxylesterase 2 expression in human colorectal cancer.
   Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T.
   Dis. Markers (2018) doi: 10.1155/2018/5280736. eCollection 2018.
2. Skewed megakaryopoiesis in human induced pluripotent stem cell-derived haematopoietic progenitor cells harbouring calreticulin mutations.
   Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S, Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M, Komatsu N.
   Br. J. Haematol. (2018) 181, 791-802.
3. Vitamin D regulates maternal T-helper cytokine production in infertile women.
   Ikemoto Y, Kuroda K, Nakagawa K, Ochiai A, Ozaki R, Murakami K, Jinushi M, Matsumoto A, Sugiyama R, Takeda S.
   Nutrients (2018) 10, E902.
4. Bone regeneration with a combination of adipose-derived stem cells and platelet-rich plasma.
   Tajima S, Tobita M, Mizuno H.
   Methods Mol. Biol. (2018) 1773, 261-272.
5. Normal pancreatic β-cell function in mice with RIP-Cre-mediated inactivation of p62/SQSTM1.
   Honda A, Komiya K, Hara A, Fukunaka A, Suzuki L, Miyatsuka T, Ogihara T, Fujitani Y, Watada H.
   Endocr. J. (2018) 65, 83-89.

2017年

1. Histone acetyltransferase p300/CREB-binding protein-associated factor (PCAF) is required for all-trans-retinoic acid-induced granulocytic differentiation in leukemia cells.
   Sunami Y, Araki M, Kan S, Ito A, Hironaka Y, Imai M, Morishita S, Ohsaka A, Komatsu N.
   J. Biol. Chem. (2017) 292, 2815-2829.
2. Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.
   Kusama H, Kon K, Ikejima K, Arai K, Aoyama T, Uchiyama A, Yamashina S, Watanabe S.
   J. Gastroenterol. (2017) 52, 611-622.
3. Promoter-level transcriptome in primary lesions of endometrial cancer identified biomarkers associated with lymph node metastasis.
   Yoshida E, Terao Y, Hayashi N, Mogushi K, Arakawa A, Tanaka Y, Ito Y, Ohmiya H, Hayashizaki Y, Takeda S, Itoh M, Kawaji H.
   Sci. Rep. (2017) 7, 14160.
4. Diminished capacity of opsonization and immune complex solubilization, and detection of anti-C1q antibodies in sera from patients with hereditary angioedema.
   Honda D, Ohsawa I, Sato N, Inoshita H, Mano S, Tomino Y, Suzuki Y.
   Allergol. Int. (2017) 66, 603-609.
5. Adipose-derived stem cells express higher levels of type VII collagen under specific culture conditions.
   Maeda Y, Hasegawa T, Wada A, Fukai T, Iida H, Sakamoto A, Ikeda S.
   Arch. Dermatol. Res. (2017) 309, 843-849.
6. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression.
   Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y.
   PLoS Genet. (2017) 13, e1006950.
7. Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.
   Sadatsuki R, Kaneko H, Kinoshita M, Futami I, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M.
   J. Orthop. Res. (2017) 35, 837-846.
8. Overexpression of RUNX1 short isoform has an important role in the development of myelodysplastic/myeloproliferative neoplasms.
   Sakurai H, Harada Y, Ogata Y, Kagiyama Y, Shingai N, Doki N, Ohashi K, Kitamura T, Komatsu N, Harada H.
   Blood Adv. (2017) 1, 1382-1386.
9. Bortezomib treatment prevents glomerulosclerosis associated with lupus nephritis in a murine model through suppressive effects on the immune and renin-angiotensin systems.
   Matsuki-Muramoto Y, Nozawa K, Uomori K, Sekigawa I, Takasaki Y.
   Mod. Rheumatol. (2017) 27, 77-86.
10. Relationship between alcohol metabolism and chemotherapy-induced emetic events in breast cancer patients.
    Uomori T, Horimoto Y, Mogushi K, Matsuoka J, Saito M.
    Breast Cancer (2017) 24, 702-707.
11. Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus.
    Nozawa K, Doe K, Uomori K, Sekigawa I, Takasaki Y, Yamaji K, Tamura N.
    Autoimmunity (2017) 50, 241-246.
12. CD44 silencing decreases the expression of stem cell-related factors induced by transforming growth factor β1 and tumor necrosis factor α in lung cancer: Preliminary findings.
    Nurwidya F, Takahashi F, Kato M, Baskoro H, Hidayat M, Wirawan A, Takahashi K.
    Bosn. J. Basic Med. Sci. (2017) 17, 228-234.
13. Influence of estrogen on the progression of kidney injury in murine IgA nephropathy.
    Kelimu A, Suzuki Y, Otsuji M, Horikoshi S, Tomino Y.
    Juntendo Med. J. (2017) 63, 178-185.

2016年

1. Activation of the thrombopoietin receptor by mutant calreticulin in CALR-mutant myeloproliferative neoplasms.
   Araki M, Yang Y, Masubuchi N, Hironaka Y, Takei H, Morishita S, Mizukami Y, Kan S, Shirane S, Edahiro Y, Sunami Y, Ohsaka A, Komatsu N.
   Blood (2016) 127, 1307-1316.
2. Antibodies to microtubule-associated protein-2 in the cerebrospinal fluid are a useful diagnostic biomarker for neuropsychiatric systemic lupus erythematosus.
   Yamada Y, Nozawa K, Nakano S, Mitsuo Y, Hiruma K, Doe K, Sekigawa I, Yamanaka K, Takasaki Y.
   Mod. Rheumatol. (2016) 26, 562-568.
3. Cathepsin D in podocytes is important in the pathogenesis of proteinuria and CKD.
   Yamamoto-Nonaka K, Koike M, Asanuma K, Takagi M, Oliva Trejo JA, Seki T, Hidaka T, Ichimura K, Sakai T, Tada N, Ueno T, Uchiyama Y, Tomino Y.
   J. Am. Soc. Nephrol. (2016) 27, 2685-2700.
4. Up-regulation of lymphocyte antigen 6 complex expression in side-population cells derived from a human trophoblast cell line HTR-8/SVneo.
   Inagaki T, Kusunoki S, Tabu K, Okabe H, Yamada I, Taga T, Matsumoto A, Makino S, Takeda S, Kato K.
   Hum. Cell (2016) 29, 10-21.
5. Identification of AIM2 as a downstream target of JAK2V617F.
   Liew EL, Araki M, Hironaka Y, Mori S, Tan TZ, Morishita S, Edahiro Y, Ohsaka A, Komatsu N.
   Exp. Hematol. Oncol. (2016) 5, 2.
6. Fundic gland differentiation of oncocytic/pancreatobiliary subtypes of pancreatic intraductal papillary mucinous neoplasms.
   Mamat O, Fukumura Y, Saito T, Takahashi M, Mitomi H, Sai J, Kawasaki S, Yao T.
   Histopathology (2016). doi: 10.1111/his.12967.
7. Adipose-derived stem cells improve collagenase-induced Tendinopathy in a rat model.
   Oshita T, Tobita M, Tajima S, Mizuno H.
   Am. J. Sports Med. (2016) 44, 1983-1989.
8. Impact of clotting condition on the measurement of circulating microRNAs in serum.
   Hayashi K, Tabe Y, Miida T.
   Clin. Lab. (2016) 62, 471-475.
9. Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases.
   Kurosawa M, Matsumoto G, Sumikura H, Hatsuta H, Murayama S, Sakurai T, Shimogori T, Hattori N, Nukina N.
   Neurosci. Res. (2016) 103, 64-70.
10. Panventriculomegaly with a wide foramen of Magendie and large cisterna magna.
    Kageyama H, Miyajima M, Ogino I, Nakajima M, Shimoji K, Fukai R, Miyake N, Nishiyama K, Matsumoto N, Arai H.
    J. Neurosurg. (2016) 124, 1858-1866.

2015年

1. JAK2, CALR, and MPL mutation spectrum in Japanese patients with myeloproliferative neoplasms.
   Shirane S, Araki M, Morishita S, Edahiro Y, Takei H, Yoo Y, Choi M, Sunami Y, Hironaka Y, Noguchi M, Koike M, Noda N, Ohsaka A, Komatsu N.
   Haematologica (2015) 100, 46-48.
2. Mutation spectrum in the Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps.
   Lee SY, Saito T, Mitomi H, Hidaka Y, Murakami T, Nomura R, Watanabe S, Yao T.
   Virchows Arch. (2015) 467, 27-38.
3. Menstrual cycle could affect Ki67 expression in estrogen receptor-positive breast cancer patients.
   Horimoto Y, Arakawa A, Tanabe M, Kuroda K, Matsuoka J, Igari F, Himuro T, Yoshida Y, Tokuda E, Shimizu H, Hino O, Saito M.
   J. Clin. Pathol. (2015)68, 825-829.
4. Keratinocyte progenitor cells reside in human subcutaneous adipose tissue.
   Hasegawa T, Sakamoto A, Wada A, Fukai T, Iida H, Ikeda S.
   PLoS One (2015) 10, e0118402.
5. TWEAK/Fn14 system and crescent formation in IgA nephropathy.
   Sasaki Y, Shimizu Y, Suzuki Y, Horikoshi S, Tomino Y.
   BMC Nephrol. (2015) 16, 27.
6. Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region.
   Murayama T, Kurebayashi N, Yamazawa T, Oyamada H, Suzuki J, Kanemaru K, Oguchi K, Iino M, Sakurai T.
   PLoS One (2015) 10, e0130606.
7. The significant role of autophagy in the granular layer in normal skin differentiation and hair growth.
   Yoshihara N, Ueno T, Takagi A, Oliva Trejo JA, Haruna K, Suga Y, Komatsu M, Tanaka K, Ikeda S.
   Arch. Dermatol. Res. (2015) 307, 159-169.
8. PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma.
   Saito T, Mitomi H, Imamhasan A, Hayashi T, Kurisaki-Arakawa A, Mitani K, Takahashi M, Kajiyama Y, Yao T.
   Mutagenesis (2015) 30, 297-301.
9. Establishment of Tsc2-deficient rat embryonic stem cells.
   Ito Y, Kawano H, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Arai H, Kobayashi T, Hino O.
   Int. J. Oncol. (2015) 46, 1944-1952.
10. Low FOXA1 expression predicts good response to neo-adjuvant chemotherapy resulting in good outcomes for luminal HER2-negative breast cancer cases.
    Horimoto Y, Arakawa A, Harada-Shoji N, Sonoue H, Yoshida Y, Himuro T, Igari F, Tokuda E, Mamat O, Tanabe M, Hino O, Saito M.
    Br. J. Cancer (2015) 112, 345-351.
11. Evaluation of the metabolic chiral inversion of d-selenomethionine in rats by stable isotope dilution gas chromatography-mass spectrometry.
    Matsukawa T, Hasegawa H, Goto H, Shinohara Y, Shinohara A, Omori Y, Ichida K, Yokoyama K.
    J. Pharm. Biomed. Anal. (2015) 116, 59-64.
12. Oral Astaxanthin supplementation prevents peritoneal fibrosis in rats.
    Wakabayashi K, Hamada C, Kanda R, Nakano T, Io H, Horikoshi S, Tomino Y.
    Perit. Dial. Int. (2015) 35, 506-516.
13. Omega 3 polyunsaturated fatty acids suppress the development of aortic aneurysms through the inhibition of macrophage-mediated inflammation.
    Yoshihara T, Shimada K, Fukao K, Sai E, Sato-Okabayashi Y, Matsumori R, Shiozawa T, Alshahi H, Miyazaki T, Tada N, Daida H.
    Circ. J. (2015) 79, 1470-1478.
14. Usefulness of BCSH Criteria for Diagnosing Japanese Polycythemia Vera.
    Yahata Y, Gotoh A, Komatsu N.
    Juntendo Med. J. (2015) 61, 287-293.
15. Sodium 4-phenylbutyrate prevents murine dietary steatohepatitis caused by trans-fatty acid plus fructose.
    Morinaga M, Kon K, Saito H, Arai K, Kusama H, Uchiyama A, Yamashina S, Ikejima K, Watanabe S.
    J. Clin. Biochem. Nutr. (2015) 57, 183-191.
16. Evaluation of the lipopolysaccharide-induced transcription of the human TREM-1 gene in vitamin D3-matured THP-1 macrophage-like cells.
    Hosoda H, Tamura H, Nagaoka I.
    Int. J. Mol. Med. (2015) 36, 1300-1310.
17. A novel method for sex determination by detecting the number of X chromosomes.
    Nakanishi H, Shojo H, Ohmori T, Hara M, Takada A, Adachi N, Saito K.
    Int. J. Legal Med. (2015) 129, 23-29.

1. JAK2V617F mutation status and allele burden in classical Ph-negative myeloproliferative neoplasms in Japan.
   Edahiro Y, Morishita S, Takahashi K, Hironaka Y, Yahata Y, Sunami Y, Shirane S, Tsutsui M, Noguchi M, Koike M, Imai K, Kirito K, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Araki M, Komatsu N.
   Int. J. Hematol. (2014) 99, 625-634.
2. Oxidative stress early in infancy and neurodevelopmental outcome in very low-birthweight infants.
   Shoji H, Ikeda N, Hosozawa M, Ohkawa N, Matsunaga N, Suganuma H, Hisata K, Tanaka K, Shimizu T.
   Pediatr Int. (2014) 56, 709-713.
3. Treatment with insulin-like growth factor 1 receptor inhibitor reverses hypoxia-induced epithelial-mesenchymal transition in non-small cell lung cancer.
   Nurwidya F, Takahashi F, Kobayashi I, Murakami A, Kato M, Minakata K, Nara T, Hashimoto M, Yagishita S, Baskoro H, Hidayat M, Shimada N, Takahashi K.
   Biochem. Biophys. Res. Commun. (2014) 455, 332-338.
4. Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.
   Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y.
   Biochem. Biophys. Res. Commun. (2014) 446, 1190-1196.
5. The synergistic effect of mizoribine and a direct renin inhibitor, aliskiren, on unilateral ureteral obstruction induced renal fibrosis in rats.
   Sakuraya K, Endo A, Someya T, Hirano D, Murano Y, Fujinaga S, Ohtomo Y, Shimizu T.
   J. Urol. (2014) 191, 1139-1146.
6. Detection of MPLW515L/K mutations and determination of allele frequencies with a single-tube PCR assay.
   Takei H, Morishita S, Araki M, Edahiro Y, Sunami Y, Hironaka Y, Noda N, Sekiguchi Y, Tsuneda S, Ohsaka A, Komatsu N.
   PLoS One. (2014) 9, e104958.
7. Kv2.1 Potassium Channel Expression Transiently Increases in Ischemic Cerebral Cortical Neurons.
   Mitsuhashi T, Ogino I, Yatomi K, Arai H.
   Juntendo Med. J. (2014) 60, 238-244.
8. Sall1, an Indispensable Protein for Kidney Development, Plays a Renoprotective Role in Podocyte Injury.
   Hosoe-Nagai Y.
   Juntendo Med. J. (2014) 60, 49-55.
9. Impact of Body Mass Index on Progression of IgA Nephropathy Among Japanese Patients.
   Shimamoto M, Ohsawa I, Suzuki H, Hisada A, Nagamachi S, Honda D, Inoshita H, Shimizu Y, Horikoshi S, Tomino Y.
   J. Clin. Lab. Anal. (2014) doi: 10.1002/jcla.21778.
10. A novel exon 17 deletion mutation of RPGRIP1 gene in two siblings with Leber congenital amaurosis.
    Suzuki T, Fujimaki T, Yanagawa A, Arai E, Fujiki K, Wada Y, Murakami A.
    Jpn. J. Ophthalmol. (2014) 58, 528-535.
11. Familial cases of Norrie disease detected by copy number analysis.
    Arai E, Fujimaki T, Yanagawa A, Fujiki K, Yokoyama T, Okumura A, Shimizu T, Murakami A.
    Jpn. J. Ophthalmol. (2014) 58, 448-454.
12. Spatiotemporal expression of TRPM4 in the mouse cochlea.
    Sakuraba M, Murata J, Teruyama R, Kamiya K, Yamaguchi J, Okano H, Uchiyama Y, Ikeda K.
    J. Neurosci. Res. (2014) 92, 1409-1418.
13. Paracrine effects of transplanted mesothelial cells isolated from temperature-sensitive SV40 large T-antigen gene transgenic rats during peritoneal repair.
    Kanda R, Hamada C, Kaneko K, Nakano T, Wakabayashi K, Hara K, Io H, Horikoshi S, Tomino Y.
    Nephrol. Dial. Transplant. (2014) 29, 289-300.
14. Notch2 activation ameliorates nephrosis.
    Tanaka E, Asanuma K, Kim E, Sasaki Y, Oliva Trejo JA, Seki T, Nonaka K, Asao R, Nagai-Hosoe Y, Akiba-Takagi M, Hidaka T, Takagi M, Koyanagi A, Mizutani S, Yagita H, Tomino Y.
    Nat. Commun. (2014) 5, 3296.
15. Commensal bacteria regulate thymic Aire expression.
    Nakajima A, Negishi N, Tsurui H, Kadowaki-Ohtsuji N, Maeda K, Nanno M, Yamaguchi Y, Shimizu N, Yagita H, Okumura K, Habu S. PLoS One (2014) 9, e105904.
16. Dietary zinc is a key environmental modifier in the progression of IgA nephropathy.
    Maiguma M, Suzuki Y, Suzuki H, Okazaki K, Aizawa M, Muto M, Tomino Y.
    PLoS One (2014) 9, e90558.
17. Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.
    Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
    BMC Nephrol. (2014) 15, 89.
18. Adipose-derived mesenchymal stem cells transplantation facilitate experimental peritoneal fibrosis repair by suppressing epithelial-mesenchymal transition.
    Wakabayashi K, Hamada C, Kanda R, Nakano T, Io H, Horikoshi S, Tomino Y.
    J. Nephrol. (2014) 27, 507-514.
19. Increased expression of CXCR3 axis components and matrix metalloproteinase in pediatric inflammatory bowel disease patients.
    Jimbo K, Ohtsuka Y, Kojima Y, Hosoi K, Ohbayashi N, Ikuse T, Aoyagi Y, Fujii T, Kudo T, Shimizu T.
    Pediatr. Int. (2014) 56, 873-883.

1. Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-A (y) Mouse.
   Furukawa M, Gohda T, Hagiwara S, Tanimoto M, Horikoshi S, Funabiki K, Tomino Y.
   Int. J. Nephrol. (2013) doi: 10.1155/2013/519130.
2. Amelioration of angiotensin II-induced salt-sensitive hypertension by liver-type fatty acid-binding protein in proximal tubules.
   Osaki K, Suzuki Y, Sugaya T, Tanifuji C, Nishiyama A, Horikoshi S, Tomino Y.
   Hypertension (2013) 62, 712-718.
3. Usefulness of HPLC assay for early detection of microalbuminuria in chronic kidney disease.
   Horikoshi S, Okuda M, Nishimura E, Ohsawa I, Suzuki Y, Shimizu Y, Hamada C, Tomino Y.
   J. Clin. Lab. Anal. (2013) 27, 333-338.
4. Acceleration of crescent formation by L1 retrotransposon in mouse BSA-induced nephritis.
   Mugitani N, Shimizu Y, Satake K, Suzuki Y, Horikoshi S, Tomino Y.
   J. Nephrol. (2013) 26, 375-384.
5. Cytoplasmic reactive oxygen species and SOD1 regulate bone mass during mechanical unloading.
   Morikawa D, Nojiri H, Saita Y, Kobayashi K, Watanabe K, Ozawa Y, Koike M, Asou Y, Takaku T, Kaneko K, Shimizu T.
   J. Bone Miner. Res. (2013) 28, 2368-2380.
6. Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.
   Sunami Y, Araki M, Hironaka Y, Morishita S, Kobayashi M, Liew EL, Edahiro Y, Tsutsui M, Ohsaka A, Komatsu N.
   PLoS One (2013) 8, e57633.
7. Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment.
   Jin L, Tabe Y, Lu H, Borthakur G, Miida T, Kantarjian H, Andreeff M, Konopleva M.
   Cancer Lett. (2013) 329, 45-58.
8. Inositol 1,4,5-trisphosphate receptor regulates replication, differentiation, infectivity and virulence of the parasitic protist Trypanosoma cruzi.
   Hashimoto M, Enomoto M, Morales J, Kurebayashi N, Sakurai T, Hashimoto T, Nara T, Mikoshiba K.
   Mol. Microbiol. (2013) 87, 1133-1150.
9. Folliculin regulates cyclin D1 expression through cis-acting elements in the 3' untranslated region of cyclin D1 mRNA.
   Kawai A, Kobayashi T, Hino O.
   Int. J. Oncol. (2013) 42, 1597-1604.

1. Relationships between levels of urinary podocalyxin, number of urinary podocytes, and histologic injury in adult patients with IgA nephropathy.
   Asao R, Asanuma K, Kodama F, Akiba-Takagi M, Nagai-Hosoe Y, Seki T, Takeda Y, Ohsawa I, Mano S, Matsuoka K, Kurosawa H, Ogasawara S, Hirayama Y, Sekine S, Horikoshi S, Hara M, Tomino Y.
   Clin. J. Am. Soc. Nephrol. (2012) 7, 1385-1393.
2. Familial nonsyndromic craniosynostosis with specific deformity of the cranium.
   Shimizu A, Komuro Y, Miyajima M, Arai H.
   J. Neurosurg. Pediatr. (2012) 10, 560-564.
3. Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes.
   Hashimoto A, Suzuki Y, Suzuki H, Ohsawa I, Brown R, Hall S, Tanaka Y, Novak J, Ohi H, Tomino Y.
   Am. J. Pathol. (2012) 181, 1338-1347.
4. Role of stromal microenvironment in nonpharmacological resistance of CML to imatinib through Lyn/CXCR4 interactions in lipid rafts.
   Tabe Y, Jin L, Iwabuchi K, Wang RY, Ichikawa N, Miida T, Cortes J, Andreeff M, Konopleva M.
   Leukemia (2012) 26, 883-892.
5. Microarray analysis of mucosal biopsy specimens in neonates with rectal bleeding: is it really an allergic disease?
   Ohtsuka Y, Jimbo K, Inage E, Mori M, Yamakawa Y, Aoyagi Y, Suzuki M, Kudo T, Suzuki R, Shimizu T.
   J. Allergy Clin. Immunol. (2012) 129, 1676-1678.
6. Gene expression analysis using a high-resolution DNA microarray of peripheral whole blood immediately before and after leukocytapheresis for rheumatoid arthritis.
   Kusaoi M, Yamaji K, Murayama G, Yasui M, Yamada R, Hishinuma R, Nemoto T, Hohtatsu K, Kageyama M, Kawamoto T, Sugimoto K, Sekiya F, Kon T, Ogasawara M, Kempe K, Tsuda H, Takasaki Y.
   Ther. Apher. Dial. (2012) 16, 456-466.
7. Development of a model of early-onset IgA nephropathy.
   Okazaki K, Suzuki Y, Otsuji M, Suzuki H, Kihara M, Kajiyama T, Hashimoto A, Nishimura H, Brown R, Hall S, Novak J, Izui S, Hirose S, Tomino Y.
   J. Am. Soc. Nephrol. (2012) 23, 1364-1374.

1. Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking.
   Nojiri H, Saita Y, Morikawa D, Kobayashi K, Tsuda C, Miyazaki T, Saito M, Marumo K, Yonezawa I, Kaneko K, Shirasawa T, Shimizu T.
   J. Bone Miner. Res. (2011) 26, 2682-2694.
2. Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma.
   Jin L, Tabe Y, Kimura S, Zhou Y, Kuroda J, Asou H, Inaba T, Konopleva M, Andreeff M, Miida T.
   Br. J. Cancer (2011) 104, 91-100.
3. Identification of Bcl-2/IgH fusion sequences using real-time PCR and chip-based microcapillary electrophoresis.
   Tabe Y, Kawase Y, Miyake K, Satoh N, Aritaka N, Isobe Y, Oshimi K, Komatsu N, Miida T, Ohsaka A.
   Clin. Chem. Lab. Med. (2011) 49, 809-815.