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学校法人順天堂@juntendo
スポーツ健康科学部@juntendo.sakura
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スポーツ健康科学部juntendo_sakura
研究活動Research Activities

アトピー疾患研究センター

研究業績データ

主な研究業績(2017年)

1Yashiro T, Kasakura K, Oda Y, Kitamura N, Inoue A, Nakamura S, Yokoyama H, Fukuyama K, Hara M, Ogawa H, Okumura K, Nishiyama M, Nishiyama C.
The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c.
Int Immunol. 2017;29:87-94.
2
Honjo A, Nakano N, Yamazaki S, Hara M, Uchida K, Kitaura J, Nishiyama C, Yagita H, Ohtsuka Y, Ogawa H, Okumura K, Shimizu, T.
Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia.
J Allergy Clin Immunol. 2017;139:987-996.e10.
3
Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J.
Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation.
J Biol Chem. 2017;292: 2924-2932.
4Ando T, Kashiwakura JI, Itoh-Nagato N, Yamashita H, Baba M, Kawakami Y, Tsai SH, Inagaki N, Takeda K, Iwata T, Shimojo N, Fujisawa T, Nagao M, Matsumoto K, Kawakami Y, Kawakami T.
Histamine-releasing factor enhances food allergy.
J Clin Invest. 2017;127:4541-4553.
5Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H.
The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors.
J Dermatol Sci. 2017;88:117-125.
6Nagaoka M, Yashiro T, Uchida Y, Ando T, Hara M, Arai H, Ogawa H, Okumura K, Kasakura K, Nishiyama C.
The orphan nuclear receptor NR4A3 is involved in the function of dendritic cells.
J Immunol. 2017;199:2958-2967.
7Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S.
Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice.
J Immunol. 2017;199:3516-3524.
8Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S.
Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice.
J Invest Dermatol. 2017;137:1578-1582.
9Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, Smyth MJ.
IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting.
Nat Commun. 2017;8:14607.
10Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J.
Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment.
Sci Rep. 2017;7:4298.

主な研究業績(2016年)

1Sato K, Oiwa R, Kumita W, Henry R, Sakuma T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara N, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Hata J, Okano H, Sasaki E.
Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.
Cell Stem. Cell., 2016;19:(1):127-138.
2
Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J.
Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.
Gut., 2016;65:(5):777-787.
3
Todo S, Yamashita K, Goto R, Zaitsu M, Nagatsu A, Oura T, Watanabe M, Aoyagi T, Suzuki T, Shimamura T, Kamiyama T, Sato N, Sugita J, Hatanaka K, Bashuda H, Habu S, Demetris AJ, Okumura K.
A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation.
Hepatology., 2016;64:(2):632-643.
4Kanazawa K, Okumura K, Ogawa H, Niyonsaba F.
An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways.
Immunol. Res., 2016;64:(2):594-603.
5
Nakamura Y, Nakano N, Ishimaru K, Ando N, Katoh R, Suzuki-Inoue K, Koyanagki S, Ogawa H, Okumura K, Shibata S, Nakao A.
Inhibition of IgE-mediated allergic reaction by pharmacologically targeting the circadian clock.
J. Allergy Clin. Immunol., 2016;137:(4):1226-1235.
6
Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T.
Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain.
J. Allergy Clin. Immunol., 2016;137:(5):1613-1615.e2.
7
Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H.
Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors.
J. Dermatol. Sci., 2016;83:(3):190-199.
8
Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T.
Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes.
J. Immunol., 2016;196:(9):3559-3569.
9
Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.
Epicutaneous Allergic Sensitization by Cooperation between Allergen Protease Activity and Mechanical Skin Barrier Damage in Mice.
J. Invest. Dermatol., 2016;136:(7):1408-1417.
10
Yashiro T, Hara M, Ogawa H, Okumura K, Nishiyama C.
Critical Role of Transcription Factor PU.1 in the Function of the OX40L/TNFSF4 Promoter in Dendritic Cells.
Sci. Rep., 2016;6:34825.

英文原著(2015年)

1Ishiyama K, Yashiro T, Nakano N, Kasakura K, Miura R, Hara M, Kawai F, Maeda K, Tamura N, Okumura K, Ogawa H, Takasaki Y, Nishiyama C.
Involvement of PU.1 in NFATc1 promoter function in osteoclast development.
Allergol Int. 2015;64:241-247.
2Tanaka Y, Yamaguchi M, Suzukawa M, Arai H, Nagase H, Ohta K.
Modulation of human basophil activation by resveratrol.
Allergol Int. 2015;64 Suppl:S80-82
3Arima K, Ohta S, Takagi A, Shiraishi H, Masuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Conway SJ, Ikeda S, Izuhara K.
Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis.
Allergol Int. 2015;64:41-48.
4Takai T, Okamoto Y, Okubo K, Nagata M, Sakaguchi M, Fukutomi Y, Saito A, Yasueda H, Masuyama K.
Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines–secondary publication.
Allergol Int. 2015;64:181-186.
5Takai T, Izuhara K.
Allergens in modern society: Updated catalogs and future prospects.
Allergol Int. 2015;64:293-294.
6Ando N, Nakamura Y, Ishimaru K, Ogawa H, Okumura K, Shimada S, Nakao A.
Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.
Allergy. 2015;70:319-322.
7Nakao A, Nakamura Y, Shibata S.
The Circadian Clock Functions As A Potent Regulator of Allergic Reaction [Review].
Allergy. 2015;70:467-473.
8Nishikado H, Fujimura T, Taka H, Mineki R, Ogawa H, Okumura K, Takai T.
Cysteine protease antigens cleave CD123, the a subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion.
Biochem Biophys Res Commun. 2015;460:261-266.
9Reichenbach DK, Schwarze V, Matta BM, Tkachev V, Lieberknecht E, Liu Q, Koehn BH, Pfeifer D, Taylor PA, Prinz G, Dierbach H, Stickel N, Beck Y, Warncke M, Junt T, Schmitt-Graeff A, Nakae S, Follo M, Wertheimer T, Schwab L, Devlin J, Watkins SC, Duyster J, Ferrara JL, Turnquist HR, Zeiser R, Blazar BR.
The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.
Blood. 2015;125:3183-3192.
10Koyama K, Ohba T, Haro H, Nakao A.
Positive Association of Serum Thymic Stromal Lymphopoietin with Anti-Citrullinated Peptide Antibody in Rheumatoid Arthritis.
Clin Exp Immunol. 2015;181:239-243.
11Nakao A.
AhR We Ready for a New Cytokine to Fight Colitis?
Dig Dis Sci. 2015;60:1876-1877.
12Dhainaut M, Coquerelle C, Uzureau S, Denoeud J, Acolty V, Oldenhove G, Galuppo A, Sparwasser T, Tielemans K, Pays E, Yagita H, Borst J, Moser M.
Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells.
EMBO J. 2015;34:1336-1348.
13Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K.
Delta-like 4-mediated Notch signaling is required for early T-cell development in a three-dimensional thymic structure.
Eur J Immunol. 2015;45-2252-2262.
14McAlees JW, Lajoie S, Dienger K, Sproles AA, Richgels PK, Yang Y, Khodoun M, Azuma M, Yagita H, Fulkerson PC, Wils-Karp M, Lewkowich IP.
Differential control of CD4+ T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.
Eur J Immunol. 2015;45:1019-1029.
15Togami K, Kitaura J, Uchida T, Inoue D, Nishimura K, Kawabata KC, Nagase R, Horikawa S, Izawa K, Fukuyama T, Nakahara F, Oki T, Harada Y, Harada H, Aburatani H, Kitamura T.
A C-terminal mutant of C/EBPa (C/EBPa-Cm) down-regulates the Csf1r, a potent accelerator in the progression of AML with C/EBPa-Cm.
Exp Hematol. 2015;43:300-308.
16Katsura Y, Harada N, Harada S, Ishimori A, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K.
Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation.
Exp Lung Res. 2015;7:1-13.
17Takeda K, Okumura K.
Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract. 
Evid Based Complement Alternat Med. 2015;2015:603198.
18Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K.
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.
Gastroenterology. 2015;148:565-578.
19Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K.
Disappearance of centroacinar cells in the Notch ligand-deficient pancreas.
Genes Cells. 2015;20:500-511.
20Endo Y, Hirahara K, Iinuma T, Shinoda K, Tumes DJ, Asou HK, Matsugae N, Obata-Ninomiya K, Yamamoto H, Motohashi S, Oboki K, Nakae S, Saito H, Okamoto Y, Nakayama T.
The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway.
Immunity. 2015;42:294-308.
21Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie A, Takahashi T, Karasuyama H, Okumura K, Azuma M, Kazuyo Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers.
Immunity. 2015;43:175-186.
22Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S.
Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection.
Immunol Res. 2015;61:240-249.
23Ito T, Egusa C, Maeda T, Numata T, Nakano N, Nishiyama C, Tsuboi R.
IL-33 promotes MHC class II expression in murine mast cells.
Immun Inflamm Dis. 2015;3:196-208.
24Yabe R, Shimizu K, Shimizu S, Azechi S, Choi BI, Sudo K, Kubo S, Nakae S, Ishigame H, Kakuta S, Iwakura Y.
CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes.
Int Immunol. 2015;27:169-181.
25Shimada S, Nunomura S, Mori S, Suemizu H, Itoh T, Takabayashi S, Okada Y, Yahata T, Shiina T, Katoh H, Suzuki R, Tani K, Ando K, Yagita H, Habu S, Sasaki E, Kametani Y.
Common marmoset CD117+ hematopoietic cells possess multipotency.
Int Immunol. 2015;27:567-577.
26Matsuda A, Asada Y, Takakuwa K, Sugita J, Murakami A, Ebihara N.
DNA methylation analysis of human trabecular meshwork cells during dexamethasone stimulation.
Invest Ophthalmol Vis Sci. 2015;56:3801-3809.
27Asada Y, Nakae S, Ishida W, Hori K, Sugita J, Sudo K, Fukuda K, Fukushima A, Suto H, Murakami A, Saito H, Ebihara N, Matsuda A.
The roles of epithelial cell-derived type 2 initiating cytokines in experimental allergic conjunctivitis.
Invest Ophthalmol Vis Sci. 2015;56:5194-5202.
28Yoshida A, Tomita T, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M.
Structure insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ-LysW complex from Thermus thermophilus.
J Biol Chem. 2015;290:435-447.
29Mager LF, Riether C, Schürch CM, Banz Y, Wasmer MH, Stuber R, Theocharides AP, Li X, Xia Y, Saito H, Nakae S, Baerlocher GM, Manz MG, McCoy KD, Macpherson AJ, Ochsenbein AF, Beutler B, Krebs P.
IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.
J Clin Invest. 2015;125:2579-2591.
30Li H, Fu YX, Wu Q, Zhou Y, Crossman DK, Li J, Luo B, Morel LM, Kabarowski JH, Yagita H, Ware CF, Hsu HC, Mounts JD.
Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus.
J Clin Invest. 2015;125:2877-2890.
31Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H.
Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes.
J Dermatol Sci. 2015;77:46-53.
32Takakuwa K, Hamanaka T, Mori K, Chin S, Shinmei Y, Funaki T, Ebihara N, Ono K, Murakami A, Matsuda A.
Atopic Glaucoma: Clinical and Pathophysiological Analysis.
J Glaucoma. 2015;24:662-668.
33Nakano N, Nishiyama C, Yagita H, Hara M, Motomura Y, Kubo M, Okumura K, Ogawa H.
Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms.
J Immunol. 2015;194:4535-4544.
34Wu J, Carlock C, Zhou C, Nakae S, Hicks J, Adams HP, Lou Y.
IL-33 Is Required for Disposal of Unnecessary Cells during Ovarian Atresia through Regulation of Autophagy and Macrophage Migration.
J Immunol. 2015;194:2140-2147.
35Yamazaki S, Nakano N, Honjo A, Hara M, Maeda K, Nishiyama C, Kitaura J, Ohtsuka Y, Okumura K, Ogawa H, Shimizu T.
The Transcription Factor Ehf Is Involved in TGF-β-Induced Suppression of FcεRI and c-Kit Expression and FcεRI-Mediated Activation in Mast Cells.
J Immunol. 2015;195:3427-3435.
36Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakae S, Nakao A, Moriishi K, Nishiyama Y, Shimada S.
Mast cells play a key role in host defense against Herpes simplex virus infection through TNF-α and IL-6 production.
J Invest Dermatol. 2015;133:2170-2179.
37Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K.
Cathelicidin LL-37 Induces Semaphorin 3A Expression in Human Epidermal Keratinocytes: Implications for Possible Application to Pruritus.
J Invest Dermatol. 2015;135:2887-2890.
38Ando N, Nakamura Y, Aoki R, Ishimaru K, Ogawa H, Okumura K, Shibata S, Shimada S, Nakao A.
Circadian Gene Clock Regulates Psoriasis-Like Skin Inflammation in Mice. 
J Invest Dermatol. 2015;135:3001-3008.
39Takai T.
Immunotherapy to treat allergies: Recent advances and future prospects. [Review]
Juntendo Med J. 2015;61:580-587
40Carnec X, Meertens L, Dejarnac O, Perera-Lecoin M, Lamine Hafirassou M, Kitaura J, Ramdasi R, Schwartz O, Amara A.
The phosphatidylserine and phosphatidylethanolamine receptor CD300a binds dengue virus and enhances infection.
J Virol. 2015;90:92-102.
41Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T.
SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.
Leukemia. 2015;29:847-857
42Sato A, Nishida C, Sato-Kusubata K, Ishihara M, Tashiro Y, Gritli I, Shimazu H, Munakata S, Yagita H, Okumura K, Tsuda Y, Okada Y, Tojo A, Nakauchi H, Takahashi S, Heissig B, Hattori K.
Inhibition of plasmin attenuates murine graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.
Leukemia. 2015;29:145-156.
43Yoon JH, Sudo K, Kuroda M, Kato M, Lee IK, Han JS, Nakae S, Imamura T, Kim J, Ju JH, Kim DK, Matsuzaki K, Weinstein M, Matsumoto I, Sumida T, Mamura M.
Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.
Nat Commun. 2015;6:7600.
44Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A.
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells.
Nat Immunol. 2015;16:276-285.
45Maekawa Y, Ishifune C, Tsukumo S, Hozumi K, Yagita H, Yasutomo K.
Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.
Nat Med. 2015;21:55-61.
46Osada Y, Yamada S, Nakae S, Sudo K, Kanazawa T.
Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice.
Parasitol Int. 2015;64:13-17.
47Pichler U, Hauser M, Wolf M, Bernardi ML, Gadermaier G, Weiss R, Ebner C, Yokoi H, Takai T, Didierlaurent A, Rafaiani C, Briza P, Mari A, Behrendt H, Wallner M, Ferreira F.
Pectate lyase pollen allergens: Sensitization profiles and cross-reactivity pattern.
PLoS One. 2015;10:e0120038.
48Morita H, Arae K, Unno H, Toyama S, Motomura K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Saito H, Matsumoto K, Nakae S.
IL-25 and IL-33 Contribute to Development of Eosinophilic Airway Inflammation in Epicutaneously Antigen-Sensitized Mice.
PLoS One. 2015;10:e0134226.
49Yashiro T, Kubo M, Ogawa H, Okumura K, Nishiyama C.
PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells. 
PLoS One. 2015;10:e0137699.
50Nishio J, Baba M, Atarashi K, Tanoue T, Negishi H, Yanai H, Habu S, Hori S, Honda K, Taniguchi T.
Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis.
Proc Natl Acad Sci U S A. 2015;112:12770-12775.
51Itoigawa Y, Harada N, Harada S, KatsuraY, Makino F, Ito J, Nurwidya F, Kato M, Takahashi F, Atsuta R, Takahashi K.
TWEAK enhances TGF-beta-induced epithelial-mesenchymal transition in human bronchial epithelial cells.
Respir Res. 2015;16:48.
52Seko Y, Fujimura T, Yao T, Taka H, Mineki R, Okumura K, Murayama K.
Secreted tyrosine sulfated-eIF5A mediates oxidative stress-induced apoptosis.
Sci Rep. 2015;5:13737.
53Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H.
Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.
Stem Cells Transl Med. 2015;4:708-719.

英文原著(2014年)

1Zhang C, Ohno T, Kang S, Takai T, Azuma M.
Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets.
Vaccine. 2014;32:5669-5676.
2Uchiyama M, Jin X, Matsuda H, Bashuda H, Imazuru T, Shimokawa T, Yagita H, Niimi M.
An agonistic anti-BTLA mAb (3C10) induced generation of IL-10-dependent regulatory CD4+ T cells and prolongation of murine cardiac allograft.
Transplantation. 2014;97:301-309.
3Nakashima R, Imura Y, Hosono Y, Aeto M, Murakami A, Watanabe K, Handa T, Mishima M, Hirakata M, Takeuchi T, Fujio K, Yamamoto K, Kohsaka H, Takasaki Y, Enomoto N, Suda T, Chida K, Hisata S, Nukiwa T, Mimori T.
The multicenter study of a new assay for simultaneous detection of multiple anti-aminoacyl-tRNA synthetases in myositis and interstitial pneumonia.
PLoS One. 2014;9:e85062.
4Oh-oka K, Kono H, Ishimaru K, Miyake K, Kubota T, Ogawa H, Okumura K, shibata S, Nakao A.
Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.
PLoS One. 2014;9:e98016.
5Murata A, Yoshino M, Hikosaka M, Okuyama K, Zhou L, Sakano S, Yagita H, Hayashi SI.
An evolutionary-conserved function of mammalian Notch family members as cell adhesion molecules.
PLoS One. 2014;9:e108535.
6Kojima R, Ohno T, Iikura M, Niki T, Hirashima M, Iwaya K, Tsuda H, Nonoyama S, Matsuda A, Saito H, Matsumoto K, Nakae S.
Galectin-9 enhances cytokine secretion, but suppresses survival and degranulation, in human mast cell line.
PLoS One. 2014;9:e86106.
7Nakajima A, Negishi N, Tsurui H, Kadowaki-Ohtsuji N, Maeda K, Nanno M, Yamaguchi Y, Shimizu N, Yagita H, Okumura K, Habu S.
Commensal Bacteria Regulate Thymic Aire Expression.
Plos One. 2014;9:e1105904.
8Mori M, Ohtsuka Y, Ishida A, Yamazaki S, Jimbo K, Inage E, Aoyagi Y, Kudo T, Suzuki R, Shimizu T.
Outcome of infants presenting rectal bleeding: a retrospedtive study in a single institution.
Pediatr Int. 2014;56:884-890.
9Jimbo K, Ohtsuka Y, Kojima Y, Hosoi K, Ohbayashi N, Ikuse T, Aoyagi Y, Fujii T, Kudo T, Shimizu T.
Increased expression of CXCR3 axis components and MMPs in pediatric IBD patients.
Pediatr Int. 2014;56:73-83.
10Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA.
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal to the thymic differentiation of regulatory T cells.
Nat Immunol. 2014;15:473-481.
11Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii K, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng LG, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K.
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.
Nat Immunol. 2014;15:1064-1071.
12Tanaka E, Asanuma K, Kim E, Sasaki Y, Oliva Trejo JA, Seki T, Nonaka K, Asao R, Nagai-Hosoe Y, Akiba-Takagi M, Hidaka T, Takagi M, Koyanagi A, Mizutani S, Yagita H, Tomino Y.
Notch2 activation ameliorates nephrosis.
Nat Commun. 2014;5:3296.
13Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song HY, Hoshino T, Yagita H, Ohteki T, Iwata M.
Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
Mucosal Immunol. 2014;7:786-801.
14Starkey MR, Nguyen DH, Essilfie AT, Kim RY, Hatchwell LM, Collison AM, Yagita H, Foster PS, Horvat JC, Mattes J, Hansbro PM.
Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease.
Mucosal Immunol. 2014;7:478-488.
15Faustino L, Fonseca DM, Florsheim EB, Resende RR, Lepique AP, Faquim-Mauro E, Gomes E, Silva JS, Yagita H, Russo M.
Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation.
Mucosal Immunol. 2014;7:1199-1208.
16Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K.
TSLP expression induced via Toll-like receptor pathways in human keratinocytes. [Review]
Methods Enzymol. 2014;535:371-387.
17Tomita O, Iijima K, Ishibashi T, Osumi T, Kobayashi K, Okita H, Saito M, Mori T, Shimizu T, Kiyokawa N.
Sensitivity of SNX2-ABL1 toward tyrosine kinase inhibitors distinct from that of BCR-ABL1.
Leuk Res. 2014;38:361-370.
18Nakajima S, Kitoh A, Egawa G, Natsuaki Y, Nakamizo S, Moniaga CS, Otsuka A, Honda T, Hanakawa S, Amano W, Iwakura Y, Nakae S, Kubo M, Miyachi Y, Kabashima K.
IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models.
J Invest Dermatol. 2014;134:2122-2130.
19Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Okumura K, Ikeda S, Ogawa H.
Host defense (antimicrobial) peptide, humanβ-defensin-3, improves the function of the epithelial tight junction barrier in human keratinocytes.
J Invest Dermatol. 2014;134:2163-2173.
20Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S.
The Human Cathelicidin LL-37 Host Defense Peptide Upregulates Tight Junction-Related Proteins and Increases Human Epidermal Keratinocyte Barrier Function.
J Innate Immun. 2014;6:739-753.
21Nakao A.
Temporal regulation of cytokines by the circadian clock. [Review]
J Immunol Res. 2014;2014:614529.
22Nakamura Y, Ishimaru K, Tahara Y, Shibata S, Nakao A.
Disruption of the Suprachiasmatic Nucleus Blunts A Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice.
J Immunol Res. 2014;2014:474217.
23Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, Kondo E, Tanaka T, Chen L, Azuma M, Yagita H, Tanimoto M.
Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease.
J Immunol. 2014;193:2565-2573.
24Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C.
Critical roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2.
J Immunol. 2014;192:3936-3946.
25Condamine T, Kumar V, Ramachandran IR, Youn J, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI.
ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis.
J Clin Invest. 2014;124:2626-2639.
26Nakamura Y, Nakano N, Ishimaru K, Hara M, Ikegami T, Tahara Y, Katoh R, Ogawa H, Okumura K, Shibata S, Nishiyama C, Nakao A.
Circadian regulation of allergic reaction by the mast cell clock in mice.
J Allergy Clin Immunol. 2014;133:568-575.
27Tanaka Y, Nakase Y, Yamaguchi M, Sugimoto N, Ohara K, Nagase H, Ohta K.
Allergy to Formaldehyde: Basophil Histamine-Release Test Is Useful for Diagnosis.
Int Arch Allergy Immunol. 2014;164:27-29.
28Fukumoto S, Toshimitsu T, Matsuoka S, Maruyama A, Oh-oka K, Takamura T, Nakamura Y, Ishimaru K, Fujii-Kuriyama Y, Ikegami S, Itou H, Nakao A.
Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis.
Immunol Cell Biol. 2014;92:460-465.
29Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M.
Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation.
Immunity. 2014;40:758-771.
30Kasakura K, Takahashi K, Ito T, Hosono A, Nunomura S, Ra C, Momose Y, Ito K, Nishiyama C, Kaminogawa S.
C/EBPalpha controls mast cell function.
FEBS Lett. 2014;588:4645-4653.
31Negishi N, Suzuki D, Ito R, Irie N, Matsuo K, Yahata T, Nagano K, Aoki K, Ohya K, Hozumi K, Ando K, Tamaoki N, Ito M, Habu S.
Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1.
Exp Hematol. 2014;42:487-494.
32Asada Y, Ebihara N, Funaki T, Norihiko Y, Murakami A, Matsuda A
Vernal keratoconjunctivitis with giant papillae on the inferior tarsal conjunctiva.
Cornea. 2014;33:32-34.
33Ishida W, Harada Y, Fukuda K, Taguchi O, Yagita H, Fukushima A.
Inhibition of very late antigen-4 and leukocyte function-associated antigen-1 in experimental autoimmune uveoretinitis.
Clin Immunol. 2014;153:136-144.
34Okayama Y, Matsuda A, Kashiwakura JI, Sasaki-Sakamoto T, Nunomura S, Shimokawa T, Yamaguchi K, Takahashi S, Ra C.
Highly expressed cytoplasmic FcεRIβ in human mast cells functions as a negative regulator of the FcRγ-mediated cell activation signal.
Clin Exp Allergy. 2014;44:238-249.
35Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H, Miyazaki D.
Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement.
Br J Ophthalmol. 2014;98:1023-1027.
36Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, Niyonsaba F.
The antimicrobial protein S100A7/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier.
Br J Dermatol. 2014;171:742-753.
37Kasakura K, Takahashi K, Ito T, Hosono A, Momose Y, Ito K, Nishiyama C, Kaminogawa S.
Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner.
Biosci Biotechnol Biochem. 2014;78:1669-1676.
38Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, Akiba H.
OX40 ligand regulates splenic CD8(-) dendritic cell-induced Th2 responses in vivo.
Biochem Biophys Res Commun. 2014;444:235-240.
39Shimura E, Shibui A, Narushima S, Nambu A, Yamaguchi S, Akitsu A, Leonard WJ, Iwakura Y, Matsumoto K, Suto H, Okumura K, Sudo K, Nakae S.
Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.
Biochem Biophys Res Commun. 2014;453:1-6.
40Aihara Y, Oh-oka K, Kondo N, Ishimaru K, Hara M, Yamagata Z, Nakao A.
Comparison of colostrum TGF-β2 levels between lactating women in Japan and Nepal.
Asian Pac J Allergy Immunol. 2014;32:178-184.
41Sekine C, Nanki T, Yagita H.
Macrophage-derived Delta-like 1 enhances interleukin-6 and matrix metalloproteinase-3 production by fibroblast-like synoviocytes in arthritic mice.
Arthritis Rheumatol. 2014;66:2751-2761.
42Nakao A, Ito T, Han X, Lu YJ, Hisata K, Tsujiwaki A, Matsunaga N, Komatsu M, Hiramatsu K, Shimizu T
Intestinal carriage of methicillin-resistant Staphylococcus aureus in nasal MRSA carriers hospitalized in the neonatal intensive care unit.
Antimicrob Resist Infect Control. 2014;3:14.
43Unno H, Futamura K, Morita H, Kojima R, Arae K, Nakae S, Ida H, Saito H, Matsumoto K, Matsuda A.
Silica and double-stranded RNA synergistically induce bronchial epithelial apoptosis and airway inflammation.
Am J Respir Cell Mol Biol. 2014;51:334-353.
44Nozaki Y, Kitching AR, Akiba H, Yagita H, Kinoshita K, Funauchi M, Matsumura I.
Endogenous Tim-1 promotes severe systemic autoimmunity and renal disease in MRL-lpr mice.
Am J Physiol Renal Physiol. 2014;306:F1210-1221.
45Nakase Y, Yamaguchi M, Sugimoto N, Nagase H, Ohta K.
Modulation of human basophil degranulation by geranylgeranyl compounds.
Allergol Int. 2014;63:49-51.
46Nakase Y, Yamaguchi M, Sugimoto N, Nagase H, Ohta K.
Suppression of human basophil desensitization by acetylsalicylic Acid.
Allergol Int. 2013;63:127-128.
47Ohta K, Ichinose M, Nagase H, Yamaguchi M, Sugiura H, Tohda Yuji, Yamauchi K, Adachi M, Akiyama K, Japanese Society of Allergology.
Japanese guideline for adult asthma 2014.
Allergol Int. 2014;63:293-333.
48Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S.
Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner.
Allergol Int. 2014;63:319-226.
49Aihara Y, Oh-oka K, Kondo N, Sharma J, Shrestha N, Ishimaru K, Hara M, Yamagata Z, Nakao A.
Residential area, birth order, and dietary habit may influence TSLP levels in colostrum: Comparative study between Japan and Nepal.
Allergol Int. 2014;63:283-285.
50Fukushima A, Ebihara N.
Efficacy of Olopatadine versus Epinastine for Treating Allergic Conjunctivitis Caused by Japanese Cedar Pollen: A Double-Blind Randomized Controlled Trial
Adv Ther. 2014;31:1045-1058.
51Schendzielorz G, Dippong M, Grünberger A, Kohlheyer D, Yoshida A, Binder S, Nishiyama C, Nishiyama M, Bott M, Eggeling L.
Taking control over control: Use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways.
ACS Synth Biol. 2014;3:21-29.

英文原著(2013年)

1Ma J, Bang BR, Lu J, Eun SY, Otsuka M, Croft M, Tobias P, Han J, Takeuchi O, Akira S, Karin M, Yagita H, Kang YJ.
The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation.
Sci Signal. 2013;6:ra87.
2Nei Y, Obata-Ninomiya K, Tsutsui H, Ishiwata K, Miyasaka M, Matsumoto K, Nakae S, Kanuka H, Inase N, Karasuyama H.
GATA-1 regulates the generation and function of basophils.
Proc Natl Acad Sci USA. 2013;110:18620-18625.
3Matsumoto A, Kanai T, Mikami Y, Chu PS, Nakamoto N, Ebinuma H, Saito H, Sato T, Yagita H, Hibi T.
IL-22-producing RORgt-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis.
PLoS One. 2013;8:e62853.
4Koike M, Tanida I, Nanao T, Tada N, Iwata J-I, Ueno T, Kominami E and Uchiyama Y.
Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons.
PLoS ONE. 2013;8:e63568.
5Nakanishi W, Yamaguchi S, Matsuda A, Suzukawa M, Shibui A, Nambu A, Suto H, Saito H, Matsumoto K,Yamasoba T, Nakae S.
IL-33, but not IL-25, is crucial for the development of house dust mite antigen-induced allergic rhinitis in mice.
PLoS One. 2013;8:e78099.
6Miyajima M, Nakajima M, Motoi Y, Moriya M, Sugano H, Ogino I, Nakamura E, Tada N, Kunichika M, Arai H.
Leucine-rich α2-glycoprotein is a novel biomarker of neurodegenerative disease in human cerebrospinal fluid and causes neurodegeneration in mouse cerebral cortex.
PLoS ONE. 2013;8:e74453.
7Van der Werf N, Redpath NA, Azuma M, Yagita H, Taylor MD.
Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection.
PLoS Pathog. 2013;9:e1003215.
8Fujinaga S, Shimizu T.
Chronic cyclosporine-induced nephrotoxity in children with steroid-resistant nephrotic syndrome.
Pediatr Nephrol. 2013;28:2065-2066.
9Fujitake Y, Ohtsuka Y, Ikuse T, Ohtani K, Aoyagi Y, Fujii T, Kudo T, Ishii M, Shimizu T.
Analysis of inflammatory signals in Japanese children with Crohn's disease.
Pediatr Int. 2013;55:753-756.
10Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyub YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ.
Inflammation-induced interstitial migration of effector CD4+ T cells is dependent on integrin αV.
Nat Immunol. 2013;14:949-958.
11Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kiramitsu S, Albers S-V, Kuzuyama T, Nishiyama M.
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Nat Chem Biol. 2013;9:277-283.
12Lewkowich IP, Lajoie S, Stoffers SL, Suzuki Y, Richgels PK, Dienger K, Sproles AA, Yagita H, Hamid Q, Wills-Karp M.
PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production.
Mucosal Immunol. 2013;6:728-739.
13Hara M, Yokoyama H, Fukuyama K, Kitamura N, Shimokawa N, Maeda K, Kanada S, Ito T, Usui Y, Ogawa H, Okumura K, Nishiyama M Nishiyama C.
Transcriptional regulation of the mouse CD11c promoter by AP-1 complex with JunD and Fra2 in dendritic cells.
Mol Immunol. 2013;53:295-301.
14Fukai T, Hiruma M, Ogawa Y, Ikeda S, Ikeda H, Sano A, Makimura K.
A case of phaeohyphomycosis caused by Exophiala oligosperma successfully treated with local hyperthermia.
Medical Mycology Journal. 2013;54:297-301.
15Zhu Y, Ohba T, Ando T, Fujita K, Koyama K, Nakamura Y, Katoh R, Haro H, Nakao A.
Endogenous TGF-β activity limits TSLP expression in the intervertebral disc tissue by suppressing NF-κB activation.
J Orthop Res. 2013;31:1144-1149.
16Niyonsaba F, Madera L, Afacan N, Okumura K, Ogawa H, Hancock RE.
The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions.
J Leukoc Biol. 2013;94:159-170.
17Aoki R, Kawamura T, Goshima F, Ogawa Y, Nakaw S, Nakao A, Moriishi K, Nishiyama Y, Shimada S.
Mast cells play a key role in host defense against herpes simplex virus infection through TNF-α and IL-6 production.
J Invest Dermatol. 2013;133:2170-2179.
18Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Takeuchi M, Baba T, Hiramatsu T, Okumura K, Ogawa H.
The expression and functional characterization of RIG-I-like receptors (RLRs) of mast cells in response to viral infection.
J Innate Immunity. 2013;5:163-173.
19Obinata K, Lee T, Niizuma T, Kinoshita K, Shimizu T, Hoshina T, Sasaki Y, Hara T.
Two cases of partial dominant interferon-γ receptor 1 deficiency that presented with different clinical courses of bacille Calmette-Guérin multiple osteomyelitis.
J Infect Chemothe. 2013;19:757-760.
20Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T.
IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.
J Immunol. 2013;190:4489-4499.
21Abe Y, Kamachi F, Kawamoto T, Makino F, Ito J, Kojima Y, Moustapha AE, Usui Y, Yagita H, Takasaki Y, Okumura K, Akiba H.
TIM-4 has dual function in the induction and effector phases of murine arthritis.
J Immunol. 2013;191:4562-4572.
22Kurosawa M, Takagi A, Tamakoshi A, Kawamura T, Inaba Y, Yokoyama K, Kitajima Y, Aoyama Y, Iwatsuki K, Ikeda S.
Epidemiology and clinical characteristics of bullous congenital ichthyosiform erythroderma (keratinolytic ichthyosis) in Japan: Results from a nationwide survey.
J Am Acad Dermatol. 2013;69:273-283.
23Ikeda S, Takahashi H, Suga Y, Eto H, Etoh T, Okuma K, Takahashi K, Kanbara T, Seishima M, Morita A, Imai Y, Kanekura T.
Therapeutic depletion of myeloid lineage leukocytes in patients with generalized pustular psoriasis indicates a major role for neutrophils in the immunopathogenesis of psoriasis.
J Am Acad Dermatol. 2013;68:609-617.
24Sugimoto N, Yamaguchi M, Tanaka Y, Nakase Y, Nagase H, Akiyama H, Ohta K.
The basophil activation test identified carminic acid as an allergen inducing anaphylaxis.
J Allergy Clin Immunol Pract. 2013;1:197-199.
25Iwamoto S, Asada Y, Ebihara N, Hori K, Okayama Y, Kashiwakura JI, Watanabe Y, Kawasaki S, Yokoi N, Inatomi T, Shinomiya K, Murakami A, Matsuda A.
Interaction between conjunctival epithelial cells and mast cells induces CCL2 expression and piecemeal degranulation in mast cells.
Invest Ophthalmol Vis Sci. 2013;54:2465-2473.
26Kitazawa K, Kawasaki S, Shinomiya K, Aoi K, Matsuda A, Funaki T, Yamasaki K, Nakatsukasa M, Ebihara N, Murakami A, Hamuro J, Kinoshita S.
Establishment of a Human Corneal Epithelial Cell Line Lacking the Functional TACSTD2 Gene as an In Vitro Model for Gelatinous Drop-Like Dystrophy.
Invest Ophthalmmol Vis Sci. 2013;54:5701-5711.
27Fukuda K, Ishida W, Tanaka H, Harada Y, Matsuda A, Ebihara N, Fukushima A.
Alarmins from corneal epithelial cells up-regulate CCL11 and VCAM-1 in corneal fibroblasts.
Invest Ophthalmol Vis Sci. 2013;54:5817-5823.
28Kasagi H, Kuhara T, Sueyoshi N, Okada H, Kurihara H, Ikeda K.
Mesenchymal stem cell transplantation to the mouse cochlea as a treatment for childhood sensorineural hearing loss.
Int J Pediatr Otorhinolaryngol. 2013;77:936-942.
29Yamada H, Iijima K, Tomita O, Taguchi T, Miharu M, Kobayashi K, Okita H, Saito M, Shimizu T, Kiyokawa N.
Effects of insulin-like growth factor-1 on B-cell precursor acute lymphoblastic leukemia.
Int J Hematol. 2013;97:73-82.
30Koketsu R, Yamaguchi M, Suzukawa M, Tanaka Y, Tashimo H, Arai H, Nagase H, Matsumoto K, Saito H, Ra C, Yamamoto K, Ohta K.
Pretreatment with low levels of FcεRI-crosslinking stimulation enhances basophil mediator release.
Int Arch Allergy Immunol. 2013;161:23-31.
31Nakashima-Kaneda K, Matsuda A, Mizuguchi H, Sasaki-Sakamoto T, Saito H, Ra C, Okayama Y.
Regulation of IgE-dependent zinc release from human mast cells.
Int Arch Allergy Immunol. 2013;161:44-51.
32Takada E, Furuhata M, Nakae S, Ichijo H, Sudo K, Mizuguchi J.
Requirement of apoptosis-inducing kinase 1 for the induction of bronchial asthma following stimulation with ovalbumin.
Int Arch Allergy Immunol. 2013;162:104-114.
33Ohtsuki A, Hasegawa T, Komiyama E, Takagi A, Ikeda S.
308-nm Excimer Lamp for the Treatment of Alopecia Areata:Clinical Trial 16 cases.
Indian J Dermatol. 2013;58:326.
34Oka A, Mabuchi T, Ikeda S, Terui T, Haida Y, Ozawa A, Yatsu K, Kulski JK, Inoko H.
IL12B and IL23R gene SNPs in Japanese psoriasis.
Immunogenetics. 2013;65:823-828.
35Haida Y, Ikeda S, Takagi A, Komiyama E, Mabuchi T, Ozawa A, Kulski JK, Inoko H, Oka A.
Association analysis of the HLA-C gene in Japanese alopecia areata.
Immunogenetics. 2013;65:553-557.
36Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Muller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, Ohteki T.
Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.
Immunity. 2013;39:584-598.
37Mashima R, Arimura S, Kajikawa S, Oda H, Nakae S, Yamanashi Y.
Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.
Genes Cells. 2013;18:56-65.
38Shibui A, Nakae S, Watanabe J, Sato Y, Tolba ME, Doi J, Shiibashi T, Nogami S, Sugano S, Hozumi N.
Screening of novel malaria DNA vaccine candidates using full-length cDNA library.
Exp Parasitol. 2013;135:546-550.
39Osada Y, Yamada S, Nabeshima A, Yamagishi Y, Ishiwata K, Nakae S, Sudo K, Kanazawa T.
Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6- and IL-10-independent mechanisms.
Exp Parasito. 2013;135:388-396.
40Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H, Takai T, Shirai T, Takasaki Y, Hirose S.
Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcRIIB-deficient C57BL/6 mice.
Eur J Immunol. 2013;43:770-778.
41Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK, Mamura M.
Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.
EMBO Mol Med. 2013;5:1720-1739.
42Cermakian N, Lange T, Golombek D, Sarkar D, Nakao A, Shibata S, Mazzoccoli G.
Crosstalk between the circadian clock circuitry and the immune system [Review].
Chronobiol Int. 2013;30:870-888.
43Hayashi A, Sato T, Kamada N, Mikami Y, Matsuoka K, Hisamatsu T, Hibi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T.
A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice.
Cell Host Microbe. 2013;13:711-722.
44Tamaichi H, Sato M, Porter AC, Shimizu T, Mizutani S, Takagi M.
ATM dependent regulation of Topoisomerase II alpha expression and sensitivity to Topoisomerase II inhibitor.
Cancer Sci. 2013;104:178-184.
45Caiado F, Carvalho T, Rosa I, Remédio L, Costa A, Matos J, Heissig B, Yagita H, Hattori K, da Silva JP, Fidalgo P, Pereira AD, Dias S.
Bone Marrow-Derived CD11b+Jagged2+ Cells Promote Epithelial-to-Mesenchymal Transition and Metastasization in Colorectal Cancer.
Cancer Res. 2013;73:4233-4246.
46Ishida W, Fukuda K, Harada Y, Sumi T, Taguchi O, Tsuda M, Yagita H, Fukushima A.
Oral administration of Ag suppresses Ag-induced allergic conjunctivitis in mice: critical timing and dose of Ag.
Br J Ophthalmol. 2013;97:492-497.
47Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S.
Biological clock dysfunction exacerbates contact hypersensitivity in mice.
Br J Dermatol. 2013;168:39-46.
48Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, Freeman GJ, Sharpe AH, Blazar BR.
Host programmed death ligand-1 is dominant over programmed death ligand-2 expression in regulating graft-versus-host disease lethality.
Blood. 2013;122:3062-3073.
49Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K.
Immunization of rabbits with nematode Ascaris lumbricoides antigens induces antibodies cross-reactive to house dust mite Dermatophagoides farinae antigens.
Biosc Biotechnol Biochem. 2013;77:145-150.
50Bian Z, Furuya N, Zheng D-M, Trejo JAO, Tada N, Ezaki J, Ueno T.
Ferulic acid induces mTor inactivation in cultured mammalian cells.
Biological & Pharmaceutical Bulletin. 2013;36:120-124.
51Chen X, Takai T, Xie Y, Niyonsaba F, Okumura K, Ogawa H.
Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes.
Biochem Biophys Res Commun. 2013;433:532-537.
52Lee H, Kashiwakura J, Matsuda A, Watanabe Y, Sakamoto-Sasaki T, Matsumoto K, Hashimoto N, Saito S, Ohmori K, Nagaoka M, Tokuhashi Y, Ra C, Okayama Y.
Activation of human synovial mast cells from rheumatoid arthritis or osteoarthritis patients in response to aggregated IgG through Fcγ receptor I and Fcγ receptor II.
Arthritis Rheum. 2013;65:109-119.
53Luo XY, Takahara T, Kawai K, Fujino M, Sugiyama T, Tsuneyama K, Tsukada K, Nakae S, Zhong L, Li XK
IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine and choline-deficient high fat diet.
Am J Physiol Gastrointest Liver Physiol. 2013;305:G891-899.
54Sugiyama T, Kitamura M, Sugita K, Hisamoto M, Okuda T, Nakao A.
Grape seed extract from "Koshu" cultivar antagonizes dioxin-induced aryl hydrocarbon receptor activation.
Am J Enol Viticult. 2013;64:146-151.
55Shirao K, Inoue M, Tokuda R, Nagao M, Yamaguchi M, Okahata H, Fujisawa T.
"Bitter sweet": a child case of erythritol-induced anaphylaxis.
Allergol Int. 2013;62:269-271.
56Nakae S, Morita H, Ohno T, Arae K, Matsumoto K, Saito H.
Role of interleukin-33 in innate-type immune cells in allergy. [Review]
Allergol Int. 2013;62:13-20.

英文原著(2012年)

1Undas A, Potaczek DP, Nishiyama C, Okumura K.
Non-severe allergic asthma is associated with elevated plasma protein C and protein S.
Thromb Haemost. 2012;107:1000-1002.
2Furusawa K, Hasegawa T, Ikeda S.
Immunosuppressant and infliximab-resistant generalized pustular psoriasis successfully treated with granulocyte and monocyte adsorpotion apheresis.
Ther Apher Dial. 2012;16:379-380.
3Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD.
The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses.
Science. 2012;335:984-989.
4Nishina T, Komazawa-Sakon S, Yanaka S, Piao X, Zheng DM, Piao JH, Kojima Y, Yamashina S, Sano E, Putoczki T, Doi T, Ueno T, Ezaki J, Ushio H, Ernst M, Tsumoto K, Okumura K, Nakano H.
Interleukin-11 links oxidative stress and compensatory proliferation.
Sci Signal. 2012;5:ra5.
5Piao X, Komazawa-Sakon S, Nishina T, Koike M, Piao J-H, Ehlken H, Kurihara H, Hara M, Van Rooijen N, Schütz G, Ohmuraya M, Uchiyama Y, Yagita H, Okumura K, He Y-W, Nakano H.
c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
Sci Signal. 2012;5:ra93.
6Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis.
Rheumatol Int. 2012;34:852-857.
7Gotot J, Gottschalk C, Leopold S, Knolle PA, Yagita H, Kurts C, Ludwig-Portugal I.
Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo.
Proc Natl Acad Sci USA. 2012;109:10468-10473.
8Okada Y, Oh-Oka K, Nakamura Y, Ishimaru K, Matsuoka S, Okumura K, Ogawa H, Hisamoto M, Okuda T, Nakao A.
Dietary resveratrol prevents the development of food allergy in mice.
PLoS One. 2012;7:e44338.
9Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Hirota T, Atsumi A, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed ow, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Minori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K.
A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese.
PLoS Genetics. 2012;8:e1002455.
10Hosozawa M, Tanaka K, Shimizu T, Nakano T, Kitazawa S.
How children with specific language impairment view social situations: an eye tracking study.
Pediatrics. 2012;129:e1453-1460.
11Okazaki T, Nishimura K, Koga H, Miyano G, Okawada M, Shoji H, Shimizu T, Makino S, Takeda S, Inada E, Lane GJ, Yamataka A.
Pulmonary artery size as an indication for thoracoscopic repair of congenital diaphragmatic hernia in neonates.
Pediatr Surg Int. 2012;28:883-886.
12Ohtsuka Y, Ikegami T, Izumi H, Namura M, Ikeda T, Ikuse T, Baba Y, Kudo T, Suzuki R, Shimizu T.
Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine.
Pediatr Res. 2012;71:46-53.
13Fujinaga S, Hirano D, Murakami H, Ohtomo Y, Shimizu T, Kaneko K.
Nephrotoxicity of once-daily cyclosporine A in minimal change nephrotic syndrome.
Pediatr Nephrol. 2012;27:671-674.
14Ikuse T, Ohtsuka Y, Kudo T, Hosoi K, Ohbayashi N, Jimbo K, Aoyagi Y, Fujii T, Nagata S, Shimizu T.
Microarray analysis of gastric mucosa among children with Helicobacter pylori infections.
Pediatr Int. 2012;54:319-324.
15Suzuki M, Inage E, Minowa K, Saito N, Naritaka N, Tsubahara M, Ohtsuka Y, Tokita A, Shimizu T.
Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients.
Pediatr Int. 2012;54:528-531.
16Nishizaki N, Suganuma H, Nagata S, Shimizu T.
Use of fibrin glue in the treatment of pneumothorax in premature infant.
Pediatr Int. 2012;54:416-419.
17Sakai R, Okumura A, Marui E, Niijima S, Shimizu T.
Does fever phobia cross borders? The case of Japan.
Pediatr Int. 2012;54:39-44.
18Ouyang Y, Nakao A, Han D, Zhang L.
Transforming growth factor-β(1) promotes nasal mucosal mast cell chemotaxis in murine experimental allergic rhinitis.
ORL J Otorhinolaryngol Relat Spec. 2012;74:117-123.
19Mosher KI*, Andres RH*, Fukuhara T*, Bieri G, Hasegawa-Moriyama M, He Y, Guzman R, Wyss-Coray T.
Neural progenitor cells regulate microglia functions and activity.
Nat Neurosci. 2012;15:1485-1487.
20Hirota T, Takahashi A, Kubo M, Tsunoda T, Tomita K, Sakashita M, Yamada T, Fujieda S, Tanaka S, Doi S, Miyatake A, Enomoto T, Nishiyama C, Nakano N, Maeda K, Okumura K, Ogawa H, Ikeda S, Noguchi E, Sakamoto T, Hizawa N, Ebe K, Saeki H, Sasaki T, Ebihara T, Amagai M, Takeuchi S, Furue M, Nakamura Y, Tamari M.
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
Nat Genet. 2012;44:1222-1226.
21Potaczek DP, Kamijo M, Hara M, Okumura K, Undas A, Nishiyama C.
A comparative search for human FcεRIα gene (FCER1A) 3'-UTR polymorphisms in Japanese and Polish populations.
Mol Biol Rep. 2012;39:3747-3753.
22Ishihara M, Nishida C, Tashiro Y, Gritli I, Rosenkvist J, Koizumi M, Okaji Y, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b(+)/F4/80(+) myeloid cell recruitment.
Leukemia. 2012;26:332-339.
23Ikejima A, Suga Y, Mizuno Y, Haruna K, Taneda K, Kourou K, Shimizu T,Yoshiike T, Ogawa Y, Ikeda S.
Clinical Manifestation and Classification of Japanese Patients with Inherited Keratinizing Disorders.
Juntendo Medical Journal. 2012;58:135-142.
24Suganuma H, Kamata A, Niizuma T, Kinoshita K, Obinata K, Shimizu T.
A case of Kawasaki disease complicated with acute pancreatitis after steroid puls tehrapy.
Juntendo Medical Journal. 2012;58:344-347.
25Kamata A, Obinata K, Niizuma T, Kinoshita K, Shimizu T.
The validity of the criteria for primary infection of Chlamydophila pneumoniae in children by measuring ELISA IgM antibodies.
J Infect Chemother. 2012;18:308-312.
26Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, Ishiwata K, Oboki K, Kambayashi T, Watanabe N, Karasuyama H, Nakae S, Inoue H, Kubo M.
Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness.
J Immunol. 2012;188:1809-1818.
27Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S.
Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma.
J Immunol. 2012;189:3641-3652.
28Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, Kubagawa H, Hiramatsu K, Yagita H, Okumura K, Takai T, Underhill DM, Aderem A, Ogasawara K.
Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence.
J Immunol. 2012;189:5903-5911.
29Negi O, Tominaga M, Tengara S, Kamo A, Taneda K, Suga Y, Ogawa H, Takamori K.
Topically applied semaphorin 3A ointment inhibits scratching behavior and improves skin inflammation in NC/Nga mice with atopic dermatitis.
J Dermatol Sci. 2012;66:37-43.
30Xie Y, Takai T, Chen X, Okumura K, Ogawa H.
Long TSLP transcript expression and release of TSLP induced by TLR ligands and cytokines in human keratinocytes.
J Dermatol Sci. 2012;66:233-237.
31Nguyen TT, Niyonsaba F, Ushio H, Akiyama T, Kiatsurayanon C, Smithrithee R, Ikeda S, Okumura K, Ogawa H.
Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-κB.
J Dermatol Sci. 2012;68:63-66.
32Hasegawa T, Suga Y, Mizuno Y, Haruna K, Ikeda S.
Photodynamic therapy using intence pulsed light for cutaneous sarcoidosis.
J Dermatol. 2012;39:564-565.
33Oikawa N, Okumura A, Oyama S, Baba H, Shimizu T, Kato A.
A 15-month-old boy with reduced consciousness and convulsion.
J Clin Virol. 2012;53:276-279.
34Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta T, Nakano H, Kabashima K, Katayama I, Koizumi S, Kodama T, Nakao A, Shimada S.
Severe dermatitis with loss of epidermal langerhans cells in human and mouse zinc deficiency.
J Clin Invest. 2012;122:722-732.
35Baba Y, Maeda K, Yashiro T, Inage E, Kasakura K, Suzuki R, Niyonsaba F, Hara M, Tanabe A, Ogawa H, Okumura K, Ohtsuka Y, Shimizu T, Nishiyama C.
GATA2 is critical transactivator for human IL1RL1/ST2 promoter in mast cells/basophils: Opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression.
J Biol Chem. 2012;287:32689-32696.
36Kitamura N, Yokoyama H, Yashiro T, Nakano N, Nishiyama M, Kanada S, Fukai T, Hara M, Ikeda S, Ogawa H, Okumura K, Nishiyama C.
Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells.
J Allergy Clin Immunol. 2012;129:814-824.
37Ohtsuka Y, Jimbo K, Inage E, Mori M, Yamakawa Y, Aoyagi Y, Suzuki M, Kudo T, Suzuki R, Shimizu T.
Microarray analysis of mucosal biopsy specimens in neonates with rectal bleeding: Is it really an allergic disease?
J Allergy Clin Immunol. 2012;129:1676-1678.
38Nagaoka I, Suzuki K, Niyonsaba F, Tamura H, Hirata M.
Modulation of neutrophil apoptosis by antimicrobial peptides.
ISRN Microbiol. 2012;2012:345791.
39Inomata T, Ebihara N, Funaki T, Matsuda A, Watanabe Y, Ning L, Xu Z, Murakami A, Arikawa-Hirasawa E.
Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure.
Invset Ophthalmol Vis Sci. 2012;53:1277-1284.
40Hori K, Matsuda A, Ebihara N, Imai K, Mori K, Funaki T, Watanabe Y, Nakatani S, Okada K, Matsuo O, Murakami A.
Involvement of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Atopic Cataracts.
Invest Ophthalmol Vis Sci. 2012;53:1846-1851.
41Matsuda R, Kezuka T*, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, Yamakawa N, Ogawa H, Okumura K, Goto H.
Suppression of the murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related peptide gene.
Invest Ophthalmol Vis Sci. 2012;53:5475-5485.
42Matsuda R, Kezuka T*, Nishiyama C, Usui Y, Matsunaga Y, Okunuki Y, Yamakawa N, Ogawa H, Okumura K, Goto H.
Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis.
Invest Ophthalmol Vis Sci. 2012;53:7235-7245.
43Heissig B, Ohki-Koizumi M, Tashiro Y, Gritli I, Sato-Kusubata K, Hattori K.
New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis.
Int J Hematol. 2012;95:131-137.
44Nunomura S, Shimada S, Kametani Y, Yamada Y, Yoshioka M, Suemizu H, Ozawa M, Itoh T, Kono A, Suzuki R, Tani K, Ando K, Yagita H, Ra C, Habu S, Satake M, Sasaki E.
Double expression of CD34 and CD117 on bone marrow progenitors is a hallmark of the development of functional mast cell of Callithrix jacchus (common marmoset).
Int Immunol. 2012;24:593-603.
45Saeki M, Nishimura T, Kaminuma O, Suzuki K, Takai T, Mori A, Takada K, Takaiwa F, Hiroi T.
Inhibition of allergen-induced airway inflammation by low-dose oral immunotherapy with transgenic rice seeds independently of immunoglobulin E synthesis.
Int Arch Allergy Immunol. 2012;158:66-69.
46Piao JH, Yagita H, Okumura K, Nakano H.
Aberrant accumulation of interleukin-10-secreting netrophils in TRAF2-deficient mice.
Immunol Cell Biol. 2012;90:881-888.
47Oshiro K, Kohama H, Umemura M, Uyttenhove C, Inagaki-Ohara K, Arakawa T, Harada M, Nakae S, Iwakura Y, Nishimaki T and Matsuzaki G.
Interleukin-17A is involved in enhancement of tumor progression in murine intestine.
Immunobiology. 2012;217:54-60.
48Elyaman W, Bassil R, BradshawEM, Orent W, Lahoud Y, Zhu B, Radtke F, Yagita H, Khoury SJ.
Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells.
Immunity. 2012;36:623-634.
49Harada M, Yokouchi Y, Oharaseki T, Matsui K, Tobayama H, Tanaka N, Akimoto K, Takahashi K, Kishiro M, Shimizu T, Takahashi K.
Histopathological characteristics of myocarditis in acute-phase Kawasaki disease.
Histopathology. 2012;61:1156-1167.
50Ishida W, Fukuda K, Kajisako M, Sumi T, Matsuda H, Yagita H, Fukushima A.
B and T lymphocyte attenuator regulates the developmemnt of antigen-induced experimental conjunctivitis.
Graefes Arch Clin Exp Ophthalmol. 2012;250:289-295.
51Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Hattori K, Heissig B.
Plasminogen deficiency attenuates post-natal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.
Exp Hematol. 2012;40:143-154.
52Ito R, Negishi N, Irie N, Matsuo K, Suzuki D, Katano I, Hayakawa E, Kawai K, Kamisako T, Eto T, Ogura T, Hozumi K, Ando K, Aiso S, Tamaoki N, Habu S, Ito M.
Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts.
Exp Hematol. 2012;40:953-963.
53Okumura A, Uematsu M, Imataka G, Tanaka M, Okanishi T, Kubota T, Sudo A, Tohyama J, Tsuji M, Ohmori I, Naiki M, Hiraiwa-Sofue A, Sato H, Saitoh S, Shimizu T.
Acute encephalopathy in children with Dravet syndrome.
Epilepsia. 2012;53:79-86.
54Tsubahara M, Shoji H, Mori M, Matsunaga N, Ikeno M, Hisata K, Okumura A, Shimizu T.
Glucose metabolism soon after birth in very premature infants with small- and appropriate-for-gestational-age birth weights.
Early Hum Dev. 2012;88:735-738.
55Minowa K, Suzuki M, Fujimura J, Saito M, Koh K, Kikuchi A, Hanada R, Shimizu T.
L-asparaginase-induced pancreatic injury is associated with an imbalance in plasma amino acid levels.
Drugs R D. 2012;12:49-55.
56Shibui A, Shimura E, Nambu A, Yamaguchi S, Leonard WJ, Okumura K, Sugano S, Sudo K, Nakae S.
Th17 cell-derived IL-17 is dispensable for B cell antibody production.
Cytokine. 2012;59:108-114.
57Fujinaga S, Endo A, Watanabe T, Hirano D, Ohtomo Y, Shimizu T, Kaneko K.
Maintenance therapy with single-daily, high-dose mizoribine after cyclophosphamide therapy for prepubertal boys with severe steroid-dependent nephrotic syndrome.
Clin Nephrol. 2012;78:251-252.
58Nishizaki N, Fujinaga S, Hirano D, Kanai H, Kaya H, Ohtomo Y, Shimizu T, Nozu K, Kaneko K.
Hereditary renal hypouricemia: a cause of calcium oxalate urolithiasis in a young female.
Clin Nephrol. 2012;77:161-163.
59Tsubahara M, Hayashi Y, Niijima S, Yamamoto M, Kamijo T, Murata Y, Haruna H, Okumura A, Shimizu T.
Isolated growth hormone deficiency in two siblings because of paternal mosaicism for a mutation in the GH1 gene.
Clin Endocrinol. 2012;76:420-424.
60Okumura A, Tsuji T, Kubota T, Ando N, Kobayashi S, Kato T, Natsume J, Hayakawa F, Shimizu T.
Acute encephalopathy with 2009 pandemic flu: Comparison with seasonal flu.
Brain Dev. 2012;34:13-19.
61Yamakawa Y, Nakazawa T, Ishida A, Saito N, Komatsu M, Matsubara T, Obinata K, Hirose S, Okumura A, Shimizu T.
A boy with a severe phenotype of succinic semialdehyde dehydrogenase deficiency.
Brain Dev. 2012;34:107-112.
62Kitamura Y, Okumura A, Hayashi M, Mori H, Takahashi S, Yanagihara K, Miyata R, Tanuma N, Mimaki T, Abe S, Shimizu T.
Oxidative stress markers and phosphorus magnetic resonance spectroscopy in a patient with GLUT1 deficiency treated with modified Atkins diet.
Brain Dev. 2012;34:372-375.
63Okumura A, Lee T, Ikeno M, Shimojima K, Kajino K, Inoue Y, Yoshikawa N, Suganuma H, Suzuki M, Hisata K, Shoji H, Takanashi JI, James Barkovich A, Shimizu T, Yamamoto T, Hayashi M.
A severe form of epidermal nevus syndrome associated with brainstem and cerebellar malformations and neonatal medulloblastom.
Brain Dev. 2012;34:881-885.
64Kamijo M, Nishiyama C, Takagi A, Nakano N, Hara M, Ikeda S, Okumura K, Ogawa H.
Cyclooxygenase-2 inhibition restores ultraviolet B-induced downregulation of ATP2A2/SERCA2 in keratinocytes: possible therapeutic approach of cyclooxygenase-2 inhibition for treatment of Darier disease.
Br J Dermatol. 2012;166:1017-1022.
65Iwamoto S, Ebihara N, Hori K, Funaki T, Asada Y, Yokoi N, Inatomi T, Kawasaki S, Murakami A, Matsuda A.
Filaggrin mutations are not associated with chronic allergic keratoconjunctivitis.
Br J Ophthalmol. 2012;96:1271-1273.
66Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells.
Blood. 2012;119:5405-5416.
67Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Tomiki Y, Sakamoto H, Dan T, Miyata T, Okumura K, Nakauchi H, Heissig B, and Hattori K.
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.
Blood. 2012;119:6382-6393.
68Kimura N, Nakae S, Itoh S, Merk DR, Wang X, Gong Y, Okamura H, Chang PA, Adachi H, Robbins RC, and Fischbein MP.
Potential role of γδ T cell-derived IL-17 in acute cardiac allograft rejection.
Ann Thorac Surg. 2012;94:542-548.
69Makino F, Ito J, Abe Y, Harada N, Kamachi F, Yagita H, Takahashi K, Okumura K, Akiba H.
Blockade of CD70-CD27 interaction inhibits induction of allergic lung inflammation in mice.
Am J Respir Cell Mol Biol. 2012;47:298-305.
70Miyuki Takagi-Akiba, Katsuhiko Asanuma, Isei Tanida, Norihiro Tada, Juan Alejandro Oliva Trejo, Kanae Nonaka, Etsuko Asanuma, Eiki Kominami, Takashi Ueno, Tomino Y.
Doxorubicin-induced glomerulosclerosis with proteinuria in GFP-GABARAP transgenic mice.
Am J Physiol - Renal Physiol. 2012;302:F380-389.
71Shimojima K, Okumura A, Mori H, Abe S, Ikeno M, Shimizu T, Yamamoto T.
De novo microdeletion of 5q14.3 excluding MEF2C in a patient with infantile spasms, microcephaly, and agenesis of the corpus callosum.
Am J Med Genet A. 2012;158:2272-2276.
72Ohno T, Morita H, Arae K, Matsumoto K, Nakae S.
Interleukin-33 in allergy. [Review]
Allergy. 2012;67:1203-1214.
73Sharma SK, Almeida FA, Kirstein F, Hortobagyi L, Lin T, Larkin A, Peterson J, Yagita H, Zangrilli JG, Haczku A.
Systemic FasL neutralization increases eosinophilic inflammation in a mouse model of asthma.
Allergy. 2012;67:328-335.
74Okayama Y, Kashiwakura J, Matsuda A, Sasaki-Sakamoto T, Nunomura S, Yokoi N, Ebihara N, Kuroda K, Ohmori K, Saito H, Ra C.
The interaction between Lyn and FcεRIβ is indispensable for FcεRI-mediated human mast cell activation.
Allergy. 2012;67:1241-1249.
75Baba Y, Maeda K, Yashiro T, Inage E, Niyonsaba F, Hara M, Suzuki R, Ohtsuka Y, Shimizu T, Ogawa H, Okumura K, Nishiyama C.
Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter.
Allergol Int. 2012;61:461-467.
76Takai T.
TSLP expression: cellular sources, triggers, and regulatory mechanisms. [Review]
Allergol Int. 2012;61:3-17.
77Morita H, Arae K, Ohno T, Kajiwara N, Oboki K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae S.
ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen- Sensitized Mice.
Allergol Int. 2012;61:265-273.

英文原著(2011年)

1Sweet RA, Ols ML, Cullen JL, Milam AV, Yagita H, Shlomchik MJ.
Facultive role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo.
Proc Natl Acad Sci USA. 2011;108:7932-7937.
2Duheron V, Hess E, Duval M, Decossas M, Castaneda B, Klopper JE, Amoasii L, Barbaroux JB, Williams IR, Yagita H, Penninger J, Choi Y, Lezot F, Groves R, Paus R, Mueller CG.
Receptor activator of NF-kB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit.
Proc Natl Acad Sci USA. 2011;108:5342-5347.
3Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, Inoue J, Matsumoto K, Sudo K, Azuma M, Okumura K, Kamradt T, Saito H, Nakae S.
Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation.
PLoS One. 2011;6:e18404.
4Otsuka A, Kubo M, Honda T, Egawa G, Nakajima S, Tanizaki H, Kim B, Matsuoka S, Watanabe T, Nakae S, Miyachi Y, Kabashima K.
Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity.
PLoS One. 2011;6:e25538.
5Noguchi E, Sakamoto H, Hirota T, Ochiai K, Imoto Y, Sakashita M, Kurosaka F, Akasawa A, Yoshihara S, Kanno N, Yamada Y, Shimojo N, Kohno Y, Suzuki Y, Kang MJ, Kwon JW, Hong SJ, Inoue K, Goto Y, Fumio Yamashita F, Asada T, Iwai N, Tomoike H, Hirose H, Saito I, Fujieda S, Hizawa N, Sakamoto T, Masuko H, Nakamura Y, Nomura I, Tamari M, Arinami T, Yoshida T, Saito H, Matsumoto K.
Genome-wide association atudy identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.
PLoS Genet. 2011;7:e1002170.
6Suzuki K, Kaminuma O, Yang L, Takai T, Mori A, Umezu-Goto M, Ohtomo T, Ohmachi Y, Noda Y, Hirose S, Okumura K, Ogawa H, Takada K, Hirasawa M, Hiroi T, Takaiwa F.
Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression.
Plant Biotechnol J. 2011;9:982-990.
7Kondo N, Suda Y, Nakao A, Oh-oka K, Suzuki K, Ishimaru K, Sato M, Tanaka T, Nagai A, Yamagata Z.
Maternal psychosocial factors determining the concentrations of transforming growth factor-beta in breast milk.
Pediatr Allergy Immunol. 2011;22:853-861.
8Ouyang Y, Nakao A, Fan E, Li Y, Zhao L, Zhang W, Han D, Zhang L.
Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis.
ORL Otorhinolaryngol Relat Spec. 2011;73:313-320.
9Kambe T, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N, Motoi Y.
Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice.
Neurobiol of Disease. 2011;42:404-414.
10Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Kinoshita S.
Two novel mutations identified in three Japanese gelatinous drop-like corneal dystrophy families.
Mol Vis. 2011;17:965-970.
11Potaczek DP, Nastalek M, Wojas-Pelc A, Okumura K, Undas A, Nishiyama C.
Naturally occurring FCER1A N222K mutation - Its ethnicity-dependent distribution and a role in atopic dermatitis.
Mol Immunol. 2011;48:979-980.
12Penaloza-Macmaster P, Rasheed AU, Iyer SS, Yagita H, Blazar B, Ahmed R.
Opposing effects of CD70 costimulation during acute and chronic viral infection.
J Virol. 2011;85:6168-6174.
13Fujita K, Ando T, Ohba T, Wako M, Sato N, Nakamura Y, Ohnuma Y, Hara Y, Kato R, Nakao A, Haro H.
Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulation.
J Orthop Res. 2011;30:599-605.
14Takeda K, Nakayama M, Sakaki M, Hayakawa Y, Imawari M, Ogasawara K, Okumura K, Smyth MJ.
IFN-γ production by lung NK cells is critical for the natural resistance to pulmonary metastasis of B16 melanoma in mice..
J Leukoc Biol. 2011;90:777-785.
15Kawamura T, Ogawa Y, Shimozato O, Ando T, Nakao A, Kobata T, Okumura K, Yagita H, Shimada S.
CD70 is selectively expressed on Th1 but not on Th2 cells and is required for Th1-type immune responses.
J Invest Dermatol. 2011;131:1251-1261.
16Bassil R, Zhu B, Lahoud Y, Riella LV, Yagita H, Elyaman W, Khoury SJ.
Notch ligand Delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development.
J Immunol. 2011;187:2322-2328.
17Hams E, McCarron MJ, Amu S, Yagita H, Azuma M, Chen L, Fallon PG.
Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.
J Immunol. 2011;186:5648-5655.
18Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K.
Leptin enhances survival and induces migration, degranulation and cytokine synthesis of human basophils.
J Immunol. 2011;186:5254-5260.
19Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Cruikshank WW, Kornfeld H, Robbins RC and Fischbein MP.
Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model.
J Heart Lung Transplant. 2011;30:1409-1417.
20Kamanaka M, Zenewicz LA, Huber S, Gagliani N, Rathinam C, O’Connor W Jr, Wang YY, Nakae S, Iwakura Y, Hao L and Flavell RA.
Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22 dependent intestinal pathology.
J Exp Med. 2011;208:1027-1040.
21Potaczek DP, Nastalek M, Okumura K, Wojas-Pelc A, Undas A, Nishiyama C.
An association of TLR2-16934A>T polymorphism and severity/phenotype of atopic dermatitis.
J Eur Acad Deramatol Venereol. 2011;25:715-721.
22Aung G, Niyonsaba F, Ushio H, Hoq MI, Ikeda S, Ogawa H, Okumura K.
A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases.
J Dermatol Sci. 2011;61:142-144.
23Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S.
Viral infection induces Thymic stromal lymphopoietin (TSLP) in human keratinocytes.
J Dermatol Sci. 2011;62:131-134.
24Aung G, Niyonsaba F, Ushio H, Ikeda S, Okumura K, Ogawa H.
Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-kappaB activation.
J Dermatol Sci. 2011;63:128-131.
25Hoq MI, Niyonsaba F, Ushio H, Aung G, Okumura K, Ogawa H.
Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes.
J Dermatol Sci. 2011;64:108-118.
26Aihara M, Hasegawa T, Okuyama Y, Hiruma M, Ikeda S.
Langerhans cell histiocytosis treated with narrow-band ultraviolet B.
J Dermatol. 2011;38:151-154.
27Shukuya R, Hasegawa T, Niwa Y, Okuma K, Ikeda S.
Granulocyte and monocyte adsorption apheresis for generalized pustular psoriasis.
J Dermatol. 2011;38:1130-1134.
28Nakano N, Nishiyama C, Yagita H, Koyanagi A, Ogawa H, Okumura K.
Notch1-mediated signaling induces MHC class II expression through the activation of class II transactivator promoter III in mast cells.
J Biol Chem. 2011;286:12042-12048.
29Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N, Nakano H.
Tumor necrosis factor receptor-associated factor (TRAF) 2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.
J Biol Chem. 2011;286:17879-17888.
30Nomura I, Morita H, Hosokawa S, Hoshina H, Fukuie T, Watanabe M, Ohtsuka Y, Shoda T, Terada A, Takamasu T, Arai K, Ito Y, Ohya Y, Saito H, Matsumoto K.
Cluster analysis reveals four distinct subtypes of non-IgE-mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms.
J Allergy Clin Immun. 2011;127:685-688.
31Nakamura Y, Harama D, Shimokawa N, Hara M, Suzuki R, Tahara Y, Ishimaru K, Katoh R, Okumura K, Ogawa H, Shibata S, Nakao A.
Circadian clock gene Period2 regulates a time-of-day-dependent variation in cutaneous anaphylactic reaction.
J Allergy Clin Immunol. 2011;127:1038-1045.
32Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H.
Crucial role for autophagy in degranulation of mast cells.
J Allergy Clin Immunol. 2011;127:1267-1276.
33Ishida W, Fukuda K, Sakamoto S, Koyama N, Koyanagi A, Yagita H, Fukushima A.
Regulation of experimental autoimmune uveoretinitis by anti-Delta-like ligand 4 monoclonal antibody.
Invest Opthalmol Vis Sci. 2011;52:8224-8230.
34Ebihara N, Matsuda A , Nakamura S, Matsuda H, Murakami A.
Role of the IL-6 classic and trans-signaling pathways in corneal sterile inflammation and wound healing.
Invset Ophthalmol Vis Sci. 2011;52:8549-8557.
35Potaczek D, Pieculewicz M, Mazur M, Branicka A, Nishiyama C, Okumura K, Undas A.
Very rare minor homozygous GG genotype of tissue factor +5466A>G mutation in a patient with two cryptogenic cerebovascular ischemic events.
Int J Cardiol. 2011;147:e13-15.
36Matsumoto K, Fukuda S, Hashimoto N, Saito H.
Human eosinophils produce and release a novel chemokine, CCL23, in vitro.
Int Arch Allergy Immunol. 2011;155:34-35.
37Le TA, Takai T, Vu AT, Kinoshita H, Chen X, Ikeda S, Ogawa H, Okumura K.
Flagellin induces the expression of thymic stromal lymphopoietin in human keratinocytes via Toll-like receptor 5.
Int Arch Allergy Immunol. 2011;155:31-37.
38Iikura K, Katsunuma T, Saika S, Saito S, Ichinohe S, Ida H, Saito H, Matsumoto K.
Peripheral blood mononuclear cells from patients with bronchial asthma show impaired innate immune responses to rhinovirus in vitro.
Int Arch Allergy Immunol. 2011;155:27-33.
39Takai T.
Missions of protease allergens in the epithelium. [Editorial]
Int Arch Allergy Immunol. 2011;154:3-5.
40Yamada Y, Matsumoto K, Hashimoto N, Saikusa M, Homma T, Yoshihara S, Saito H.
Effect of Th1/Th2 cytokine pretreatment on RSV-induced gene expression in airway epithelial cells.
Int Arch Allergy Immunol. 2011;154:184-194.
41Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K.
Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines.
Immunology. 2011;132:527-539.
42Ishida W, Fukuda K, Sumi T, Ebihara N, Kajisako M, Matsuda H, Yagita H, Fukushima A.
Adjuvants determine the contribution of basophils to antigen sensitization in vivo.
Immunol Lett. 2011;136:49-54.
43Takamura T, Harama D, Fukumoto S, Nakamura Y, Shimokawa N, Ishimaru K, Ikegami S, Makino S, Kitamura M, Nakao A.
Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis.
Immunol Cell Biol. 2011;89:817-822.
44Ohwada A, Inami K, Onuma E, Matsumoto-Yamazaki M, Atsuta R, Takahashi K.
Bronchial reversibility with a short-acting β2-agonist predicts the FEV1 response to administration of a long-acting β2-agonist with inhaled corticosteroids in patients with bronchial asthma.
Exp Ther Med. 2011;2:619-623.
45Shibui A, Doi J, Tolba MEM, Shiraishi C, Sato Y, Ishikawa S, Watanabe J, Nogami S, Nakae S, Sugano S and Hozumi N.
N-acetylglucosaminyltransferase V-deficiency increases susceptibility to murine malaria.
Exp Parasitol. 2011;129:318-321.
46Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagita H, Yasutomo K.
Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.
Eur J Immunol. 2011;41:1309-1320.
47Ebihara N, Ohtomo K, Tokura T, Ushio H, Murakami A.
Effect of Tacrolimus on Chemokine Production by Corneal Myofibroblasts viaToll-Like Receptors, Compared With Cyclosporine and Dexamethasone.
Cornea. 2011;30:702-708.
48Watanabe T, Kanamaru Y, Liu C, Suzuki Y, Tada N, Okumura K, Horikoshi S, Tomino Y.
Negative regulation of inflammatory responses by IgA receptor (FcaRI) inhibits the development of TLR9 signaling-accelerated glomerulonephritis.
Clin Exp Immunol. 2011;166:235-250.
49Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP.
Interleukin-17 accelerates allograft rejection by suppressing regulatory T cellexpansion.
Circulation. 2011;124:S187-196.
50Ebata R, Abe J, Yasukawa K, Hamada H, Higashi K, Suwazono Y, Saito H, Terai M, Kohno Y.
Increased Production of Vascular Endothelial Growth Factor-D and Lymphangiogenesis in Acute Kawasaki Disease.
Circ J. 2011;75:1455-1462.
51Meguro A, Ozaki K, Hatanaka K, Oh I, Sudo K, Ohmori T, Matsu H, Tatara R, Sato K, Sakata Y, Nakae S, Leonard WJ, and Ozawa K.
Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells.
Bone Marrow Transplant. 2011;46:1557-1565.
52Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S.
Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.
Blood. 2011;117:128-134.
53Kanada S, Nishiyama C, Nakano N, Suzuki R, Maeda K, Hara M, Kitamura N, Ogawa H, Okumura K.
Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells.
Blood. 2011;117:2211-2222.
54Nishida C, Tomita T, Nishiyama M, Suzuki R, Hara M, Itoh Y, Ogawa H, Okumura K, and Nishiyama C.
B-transferase with Pro234Ser substitution acquires AB-transferase activity.
Biosci Biotechnol Biochem. 2011;75:1570-1575.
55Ito J, Harada N, Nagashima O, Makino F, Usui Y, Yagita H, Okumura K, Dorscheid DR, Atsuta R, Akiba H, Takahashi K.
Wound-induced TGF-β1 and TGF-β2 enhance airway epithelial repair via HB-EGF and TGF-α
Biochem Biophys Res Commun. 2011;412:109-114.
56Ma J, Usui Y, Takeda K, Harada N, Yagita H, Okumura K, Akiba H.
TIM-1 signaling in B cells regulates antibody production.
Biochem Biophys Res Commun. 2011;406:223-228.
57Ezaki J, Matsumoto N, Takeda-Ezaki M, Komatsu M, Takahashi K, Hiraoka Y, Taka H, Fujimura T, Takehana K, Yoshida M, Iwata J, Tanida I, Furuya N, Zheng D-M, Tada N, Tanaka K, Kominami E, Ueno T.
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels.
Autophagy. 2011;7:727-736.
58Nakano H, Ushio H.
An unexpected role for autophagy in degranulation of mast cells.
Autophagy. 2011;7:657-659.
59Kawamoto T, Abe Y, Ito J, Makino F, Kojima Y, Usui Y, Ma J, Morimoto S, Yagita H, Okumura K, Takasaki Y, Akiba H.
Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells.
Arthritis Res Ther. 2011;13:R47.
60Funakushi N, Yamaguchi T, Jiang J, Imamura S, Kuhara T, Suto H, Ueki R, Kase Y, Kobayashi H, Ogawa H, Ikeda S.
Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice.
Arch Dermatol Res. 2011;303:659-667.
61Ng W, Ikeda S.
Use of sun-protective items by Japanese pedestrians: a cross-sectional observational study.
Arch Dermatol. 2011;147:1167-1170.
62Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, Tamari M.
TSLP promoter polymorphisms are associated with susceptibility to bronchial asthma.
Am J Respir Cell Mol Biol. 2011;44:787-793.
63Oboki K, Nakae S, Matsumoto K, Saito H.
IL-33 and airway inflammation. [Review]
Allergy Asthma Immunol Res. 2011;3:81-88.
64Ohta K, Bousquet PJ, Aizawa H, Akiyama K, Adachi M, Ichinose M, Ebisawa M, Tamura G, Nagai A, Nishima S, Fukuda T, Morikawa A, Okamoto Y, Kohno Y, Saito H, Takenaka H, Grouse L, Bousquet J.
Prevalence and impact of rhinitis in asthma. SACRA, a cross-sectional nation-wide study in Japan.
Allergy. 2011;66:1287-1295.
65Takai T, Ikeda S.
Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases. [Review]
Allergol Int. 2011;60:25-35.
66Arae K, Oboki K, Ohno T Hirata M, Nakae S, Taguchi T, Saito H, Nakajima T.
Cimetidine enhances antigen-specific IgE and Th2 cytokine production.
Allergol Int. 2011;60:339-344.
67Shibui A, Nambu A, Shimura E, Yamaguchi S, Shiraishi C, Sato Y, Okumura K, Sugano S, Hozumi N, Nakae S.
Alteration of immune responses by N-acetylglucosaminyltransferase V during allergic airway inflammation.
Allergol Int. 2011;60:345-354.
68Sano Y, Yamada H, Ogawa C, Yamaguchi M.
Some asthmatics show elevation of the peripheral venous oxygen pressure (PvO(2)).
Allergol Int. 2011;60:109-110.
69Ng W, Ikeda S.
Standardized, defined serum-free culture of a human skin equivalent on fibroblast-populated collagen scaffold.
Acta Derm Venereol. 2011;91:387-391.

英文原著(2010年)

1Potaczek D, Owczarek D, Okumura K, Mach T, Undas A, and Nishiyama C.
An association between functional FcepsilonRIalpha polymorphisms and total serum IgE levels in patients with inflammatory bowel disease.
Scand J Gastroenterology. 2010;45:766-767.
2Potaczek D, Owczarek D, Okumura K, Mach T, Undas A, Nishiyama C.
An association between functional FcepsilonRIalpha polymorphisms and total serum IgE levels in patients with inflammatory bowel disease.
Scand J Gastroenterol. 2010;45:766-767.
3Oboki K, Ohno T, Kajiwara K, Arae K, Morita H, Ishii A, Nambu A, Abe T, Kiyonari H, Sudo K, Okumura K, Saito H and Nakae S.
IL-33 is a crucial amplifier of innate rather than acquired immunity.
Proc Natl Acad Sci USA. 2010;107:18581-18586.
4Okada K, Fujii T, Ohtsuka Y, Yamakawa Y, Izumi H, Yamashiro Y, Shimizu T.
Overfeeding Can Cause NEC-Like Enterocolitis in Premature Rat Pups.
Neonatology. 2010;97:218-224.
5Lkhagvadorj E, Nagata S, Wada M, Bian L, Wang C, Chiba Y, Yamashiro Y, Shimizu T, Asahara T, Nomoto K.
Anti-infectious activity of synbiotics in a novel mouse model of methicillin-resistant Staphylococcus aureus infection.
Microbiol Immunol. 2010;54:265-275.
6Nishida C, Nishiyama C, Satoh K, Hara M, Itoh Y, Ogawa H, and Okumura K.
Establishment of a simple detection system for blood group ABO-specific transferase activity in DNA-transfected cells.
Legal Med. 2010;12:172-176.
7Vu AT, Takai T, Le TA, Kinoshita H, Kamijo S, Hara M, Wang XL, Ogawa T, Ikeda S, Ogawa H, Okumura K.
Proinflammatory response in human keratinocytes stimulated with ligands for TLR2, TLR1, and TLR6.
Juntendo Medical Journal. 2010;56:50-55.
8Hirasawa Y, Takai T, Nakamura T, Mitsuishi K, Gunawan H, Suto H,Ogawa T, Wang XL, Ikeda S, Okumura K, Ogawa H.
Staphylococcus aureus extracellular protease causes epidermal barrier dysfunction.
J Invest Dermatol. 2010;130:614-617.
9Takeichi T, Sugiura K, Muro Y, Matsumoto K, Ogawa Y, Futamura K, Kaminuma O, Hashimoto N, Shimoyama Y, Saito H, Tomita Y.
Overexpression of LEDGF/DFS70 induces IL-6 via p38 activation in HaCaT cells, similar to that seen in the psoriatic condition.
J Invest Dermatol. 2010;130:2760-2767.
10Kenna TJ, Waldie T, McNally A, Thomson M, Yagita H, Thomas R, Steptoe RJ.
Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function.
J Immunol. 2010;184:598-606.
11Kassner N, Krueger M, Yagita H, Dzionek A, Hutloff A, Kroczek R, Rutz S.
Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis.
J Immunol. 2010;184:550-554.
12Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K.
Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells.
J Immunol. 2010;184:3526-3534.
13Ishiwata K, Watanabe N, Guo M, Tomihara K, Brumlik MJ, Yagita H, Pardoll D, Chen L, Shin T.
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
J Immunol. 2010;184:2086-2094.
14Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, Saito H, Matsuda A.
IL-33 mediates inflammatory responses in human lung tissue cells.
J Immunol. 2010;185:5743-5750.
15Maeda K, Nishiyama C, Ogawa H, and Okumura K.
GATA2 and Sp1 positively regulate the c-kit promoter in mast cells.
J Immunol. 2010;185:4252-4260.
16Oh I, Ozaki K, Meguro A, Kadowaki M, Matsu H, Hatanaka K, Tatara R, Sato K, Iwakura Y, Nakae S, Sudo K, Teshima T, Leonard W J and Ozawa K.
Altered effector CD4+ T cell function in IL-21R-/- CD4+ T cell-mediated graft-versus-host disease.
J Immunol. 2010;185:1920-1926.
17Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, and Iwakura Y.
TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in IL1rn-/- mice.
J Immunol. 2010;185:1887-1893.
18Okamoto-Yoshida Y, Umemura M, Yahagi A, O’Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y and Matsuzaki G.
Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung.
J Immunol. 2010;184:4414-4422.
19Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K.
Antimicrobial peptides human beta-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells.
J Immunol. 2010;184:3526-3534.
20Itoh S, Nakae S, Velotta JB, Kosuge H, Connolly A, Tsai M, Adachi H, Galli SJ, Robbins RC and Fischbein MP.
The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice.
J Heart Lung Transplant. 2010;29:401-409.
21Gibb DR, Shikh ME, Kang D, Rowe WJ, Sayed RE, Cichy J, Yagita H, Tew JG, Dempsey PJ, Crawford HC, Conrad DH.
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.
J Exp Med. 2010;207:623-635.
22Yamanishi Y, Kitaura J, Izawa K,Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T .
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
J Exp Med. 2010;207:1501-1511.
23Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T.
Identification of INAM, a polyI:C-inducible membrane protein, that participates in dendritic cell-mediated natural killer cell activation.
J Exp Med. 2010;207:2675-2687.
24Sasaki T, Tsubakishita S, Tanaka Y, Sakusabe A, Ohtsuka M, Hirotaki S, Kawakami T, Fukata T, Hiramatsu K.
Multiplex-PCR method for species identification of coagulase-positive staphylococci.
J Clin Microbiol. 2010;48:765-769.
25Sakaguchi S, Saito M, Tsuji H, Asahara T, Takata O, Fujimura J, Nagata S, Nomoto K, Shimizu T.
Bacterial rRNA-targeted reverse transcription-PCR used to identify pathogens responsible for fever with neutropenia.
J Clin Microbiol. 2010;48:1624-1628.
26Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC and Fischbein MP.
IL-17 contributes to the development of chronic rejection in a murine heart transplant model.
J Clin Immunol. 2010;235-240.
27Kawamichi Y, Cui CH, Toyoda M, Makino H, Horie A, Takahashi Y, Matsumoto K, Saito H, Ohta H, Saito K, Umezawa A.
Cells of extraembryonic mesodermal origin confer human dystrophin in the Mdx model of duchenne muscular dystrophy.
J Cell Physiol. 2010;223:695-702.
28Wada M, Lkhagvadorj E, Bian L, Wang C, Chiba Y, Nagata S, Shimizu T, Yamashiro Y, Asahara T, Nomoto K.
Quantitative reverse transcription-PCR assay for the rapid detection of methicillin-resistant Staphylococcus aureus.
J Appl Microbiol. 2010;108:779-788.
29Vu AT, Baba T, Chen X, Le TA, Kinoshita H, Xie Y, Kamijo S, Hiramatsu K, Ikeda S, Ogawa H, Okumura K, Takai T.
Staphylococcus aureus membrane and diacylated lipopeptide induce thymic stromal lymphopoietin in keratinocytes via the Toll-like receptor 2-Toll-like receptor 6 pathway.
J Allergy Clin Immunol. 2010;126:985-993.
30Jin S-LC, Goya S, Nakae S, Wang D, Bruss M, Umetsu D and Conti M.
Phosphodiesterase 4B is essential for Th2 cell function and development of airway hyperresponsiveness in allergic asthma.
J Allergy Clin Immunol. 2010;126:1252-1259.
31Kajiwara N, Sasaki T, Cruse G, Bradding P, Ohmori K, Saito H, Ra C, Okayama Y.
Activation of human lung mast cells through platelet activating factor receptor.
J Allergy Clin Immunol. 2010;125:1137-1145.
32Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M.
Evaluation of the effect of α-defensins human neutrophil peptides on neutrophil apoptosis.
Int J Mol Med. 2010;26:925-934.
33Niwa Y, Potaczek D, Kanada S, Takagi A, Shimokawa N, Ito T, Mitsuishi K, Okubo Y, Tajima M, Nagai A, Ng W, Tsuboi R, Ikeda S, Ogawa H, Okumura K, and Nishiyama C.
FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.
Int J Immunogenetics. 2010;37:139-141.
34Takai T.
Missions of protease allergens in the epithelium.
Int Arch Allergy Immunol. 2010;154:3-5.
35Takai T.
Cedar allergen harvest from tobacco: Plant biotechnology for recombinant allergens.
Int Arch Allergy Immunol. 2010;153:431-433.
36Fukushima A, Ishida W, Ojima A, Kajisako M, Sumi T, Yamada J, Tsuru E, Miyazaki JI, Tominaga A, Yagita H.
Participation of CD11b and F4/80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis.
Int Arch Allergy Immunol. 2010;151:129-136.
37Le TA, Takai T, Vu AT, Kinoshita H, Ikeda S, Ogawa H, Okumura K.
Glucocorticoids inhibit double-stranded RNA-induced thymic stromal lymphopoietin release from keratinocytes in atopic cytokine milieu more effectively than tacrolimus.
Int Arch Allergy Immunol. 2010;153:27-34.
38Niiyama S, Tamauchi H, Amoh Y, Terashima M, Matsumura Y, Kanoh M, Habu S, Komotori J, Katsuoka K.
Th2 Immune Response Plays a Critical Role in the Development of Nickel-Induced Allergic Contact Dermatitis.
Int Arch Allergy Immunol. 2010;153:303-314.
39Futamura K, Orihara K, Hashimoto N, Morita H, Fukuda S, Sagara H, Matsumoto K, Tomita Y, Saito H, Matsuda A.
β2-adrenoceptor agonists enhance cytokine-induced release of thymic stromal lymphopoietin by lung tissue cells.
Int Arch Allergy Immunol. 2010;152:353-361.
40Matsumoto K, Terakawa M, Fukuda S, Saito H.
Analysis of signal transduction pathways involved in anti-CD30 mAb-induced human eosinophil apoptosis.
Int Arch Allergy Immunol. 2010;152:2-8.
41Potaczek D, Owczarek D, Cibor D, Nishiyama C, Okumura K, Mach T, and Undas A.
Tissue factor -1208D>I polymorphism is associated with D-dimer levels in patients with inflammatory bowel disease.
Inflamm Bowel Dis. 2010;16:1095-1096.
42Konkel JE, Frommer F, Leech MD, Yagita H, Waisman A, Anderton SM.
PD-1 signaling in CD4(+) T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide-induced tolerance.
Immunology. 2010;130:92-102.
43Chiba Y, Shida K, Nagata S, Wada M, Bian L, Wang C, Shimizu T, Yamashiro Y, Kiyoshima-Shibata J, Nanno M, Nomoto K.
Well-controlled proinflammatory cytokine responses of Peyer's patch cells to probiotic Lactobacillus casei.
Immunology. 2010;130:352-362.
44Wong WF, Nakazato M, Watanabe T, Kohu K, Ogata T, Yoshida N, Sotomaru Y, Ito M, Araki K, Telfer J, Fukumoto M, Suzuki D, Sato T, Hozumi K, Habu S, Satake M.
Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages.
Immunology. 2010;130:243-253.
45Takamura T, Harama D, Matsuoka S, Shimokawa N, Nakamura Y, Okumura K, Ogawa H, Kitamura M, Nakao A.
Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice.
Immunol Cell Biol. 2010;88:685-689.
46Shimokawa N, Nishiyama C, Nakano N, Maeda K, Suzuki R, Hara M, Fukai T, Tokura T, Miyajima H, Nakao A, Ogawa H, Okumura K.
Suppressive effects of transcription factor GATA-1 on cell type-specific gene expression in dendritic cells.
Immunogenetics. 2010;62:421-429.
47Uchida Y, Ke B, Freitas MC, Yagita H, Akiba H, Busuttil RW, Najafian N, Kupiec-Weglinski JW.
T cell immunoglobulin mucin-3 dictates severity of liver ischemia/ reperfusion injury in mice in TLR4-dependent manner.
Gastroenterology. 2010;139:2195-2206.
48Wang QH, Nishiyama C, Nakano N, Kanada S, Hara M, Kitamura N, Shimokawa N, Lu CL, Ogawa H, Okumura K.
Opposite effects of Trichostatin A on activation of mast cells by different stimulants.
FEBS Lett. 2010;584:2315-2320.
49Abe N, Hozumi K, Hirano KI, Yagita H, Habu S.
Notch ligands transduce different magnitudes of signaling critical for determination of T-cell fate.
Eur J Immunol. 2010;40:2608-2617.
50Aoki N, Yokoyama R, Asai N, Ohki M, Ohki Y, Kusubata K, Heissig B, Hattori K, Nakagawa Y, Matsuda T.
Adipocyte-Derived Microvesicles Are Associated with Multiple Angiogenic Factors and Induce Angiogenesis in Vivo and in Vitro.
Endocrinology. 2010;151:2567-2576.
51Nakao A.
The role and potential use of oral TGF-β in the prevention of infant allergy.
Clin Exp Allergy. 2010;40:725-730.
52Potaczek D, Kwasny-Krochin B, Nishiyama C, Okumura K, Gluszko P, and Undas A.
Tissue factor +5466A>G and -1208D>I genetic polymorphisms and severity of rheumatoid arthritis.
Clin Chem Lab Med. 2010;40:423-425.
53Tsubota A, Matsumoto K, Mogushi K, Nariai K, Namiki Y, Hoshina S, Hano H, Tanaka H, Saito H, Tada N.
IQGAP1 and vimentin are key regulator genes in naturally occurring hepatotumorigenesis induced by oxidative stress.
Carcinogenesis. 2010;31:504-511.
54Fukuie T, Nomura I, Horimukai K, Futamura M, Narita M, Ohzeki T, Matsumoto K, Saito H, Ohya Y.
Proactive treatment appears to decrease serum IgE levels in patients with severe atopic dermatitis.
Brit J Dermatol. 2010;163:1127-1129.
55Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K.
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.
Blood. 2010;115:4302-4312.
56Fukaya T, Takagi H, Sato Y, Sato K, Eizumi K, Taya H, Shin T, Chen L, Dong C, Azuma M, Yagita H, Malissen B, Sato K.
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Blood. 2010;116:2266-2276.
57Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K.
Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands.
Biochem Biophys Res Commun. 2010;391:471-476.
58Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito H, Tsuji K, Sekiya I.
Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits.
Arthritis Res Ther. 2010;12:R206.
59McGee HS, Yagita H, Shao Z, Agrawal DK.
PD-1 antibody blocks therapeutic effects of T-regulatory cells in cockroach antigen-induced allergic asthma.
Am J Respir Cell Mol Biol. 2010;43:432-442.
60Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H, Nakae S.
Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice.
Allergol Int. 2010;59:207-211.
61Toda T, Yamaguchi M, Nakase Y, Sugimoto N, Suzukawa M, Nagase H, Ohta K.
A case of anaphylactic reaction following Matsutake mushroom ingestion: Demonstration of histamine release reaction of basophils.
Allergol Int. 2010;59:417-419.
62Ishii A, Oboki K, Nambu A, Morita H, Ohno T, Kajiwara N, Arae K, Sudo H, Okumura K, Saito H, Nakae S.
Development of IL-17-mediated delayed-type hypersensitivity is not affected by down-regulation of IL-25 expression.
Allergol Int. 2010;59:399-408.
63Ouyang Y, Miyata M, Hatsushika K, Ohnuma O, Katoh R, Ogawa H, Okumura K , Masuyama K, Nakao A.
TGF-β signaling may play a role in the development of goblet cell hyperplasia in a mouse model of allergic rhinitis.
Allergol Int. 2010;59:313-319.
64Yagami A, Kajiwara N, Oboki O, Ohno N, Morita H, Sunnarborg SW, Okumura K, Ogawa H, Saito H and Nakae S.
Amphiregulin is dispensable for induction of contact hypersensitivity.
Allergol Int. 2010;59:227-284.
65Kajiwara N, Oboki K, Ohno T, Ishii A, Sunnarborg SW, Okumura K, Saito H and Nakae S.
Amphiregulin is not essential for ovalbumin-induced acute airway inflammation in mice.
Allergol Int. 2010;59:207-211.
66Oboki K, Ohno T, Kajiwara N, Saito H, Nakae S.
IL-33 and IL-33 receptors in host defense and diseases.
Allergol Int. 2010;59:143-160.
67Nambu A, Nakae S.
IL-1 and Allergy.
Allergol Int. 2010;59:125-135.

英文原著(2009年)

1Potaczek DP, Wang QH, Sanak M, Tokura T, Matsuda H, Dziedzina S, Nakano N, Hara M, Ogawa H, Szczeklik A, Okumura K, Nishiyama C.
Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes.
Tissue Antigens. 2009;74:534-538.
2Potaczek D, Pieculewicz M, Mazur M, Branicka A, Nishiyama C, Okumura K, and Undas A.
Tissue factor (TF) +5466A>G polymorphism predicts plasma TF levels in subjects with cryptogenic ischemic stroke.
Thromb. Haemost. 2009;102:173-175.
3Horie M, Sekiya I, Muneta T, Ichinose S, Matsumoto K, Saito H, Murakami T, Kobayashi E.
Intraarticular injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect.
Stem Cells. 2009;27:878-887.
4Watanabe S, Ito T, Sasaki T, Li S, Uchiyama I, Kishii K, Kikuchi K, Skov RL, Hiramatsu K.
Genetic diversity of staphylocoagulase genes (coa): insight into the evolution of variable chromosomal virulence factors in Staphylococcus aureus.
PLoS One. 2009;4:e5714.
5Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K.
Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo.
Phytother Res. 2009;23:1581-1586.
6Sasaki E, Suemizu H, Shimada A, Hanazawa K, Oiwa R, Kamioka M, Tomioka I, Sotomaru Y, Hirakawa R, Eto T, Shiozawa S, Maeda T, Ito M, Ito R, Kito C, Yagihashi C, Kawai K, Miyoshi H, Tanioka Y, Tamaoki N, Habu S, Okano H, Nomura T.
Generation of transgenic non-human primates with germline transmission.
Nature. 2009;459:523-527.
7O’Connor W Jr, Kamanaka M, Booth CJ, Town T, Nakae S, Iwakura Y, Kolls JK and Flavell RA.
A protective function for interleukin 17A in T cell-mediated intestinal inflammation.
Nat Immunol. 2009;10:603-609.
8Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, and Nishiyama M.
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
Nat Chem Biol. 2009;5:673-679.
9Abe Y, Ohtsuji M, Ohtsuji N, Lin Q, Tsurui H, Nakae S, Shirai T, Sudo K and Hirose S.
Ankylosing enthestis associated with up-regulated IFN-g and IL-17 production in (BXSB x NZB) F1 male mice; a new mouse model.
Mod Rheumatol. 2009;19:316-322.
10Ohba T, Haro H, Ando T, Wako M, Suenaga F, Aso Y, Koyama K, Hamada Y, Nakao A.
TNF-α-induced NK-κB signaling reverses age-related declines in VEGF induction and angiogenic activity in intervertebral disc tissues.
J Orthop Res. 2009;27:229-235.
11Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.
Transforming growth factor-β activity in commercially available pasteurized cow milk provides protection against inflammation in mice.
J Nutr. 2009;139:69-75.
12Nakamura Y, Miyata M, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A.
The latent form of transforming growth factor-β administered orally is activated by gastric acid in mice.
J Nutr. 2009;139:1463-1468.
13Sugiura K, Muro Y, Futamura K, Matsumoto K, Hashimoto N, Nishizawa Y, Nagasaka T, Saito H, Tomita Y, Usukura J.
The Unfolded Protein Response Is Activated in Differentiating Epidermal Keratinocytes.
J Invest Dermatol. 2009;129:2126-2135.
14Hongo I, Baba T, Oishi K, Morimoto Y, Ito T, Hiramatsu K.
Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin.
J Infect Dis. 2009;200:715-723.
15Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K.
Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.
J Immunol. 2009;182:3566-3572.
16Takai T, Kato T, Hatanaka H, Inui K, Nakazawa T, Ichikawa S, Mitsuishi K, Ogawa H, Okumura K.
Modulation of allergenicity of major house dust mite allergens Der f 1 and Der p 1 by interaction with an endogenous ligand.
J Immunol. 2009;183:7958-7965.
17Kamijo S, Takai T, Kuhara T, Tokura T, Ushio H, Ota M, Harada N, Ogawa H, Okumura K.
Cupressaceae pollen grains modulate dendritic cell response and exhibit IgE-inducing adjuvant activity in vivo.
J Immunol. 2009;183:6087-6094.
18Knoop KA, Kumar N, Butler BR, Sakthivel SK, Taylor RT, Nochi T, Akiba H, Yagita H, Kiyono H, William IR.
RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium.
J Immunol, 2009;183:5738-5747.
19Ohno T, Oboki T, Kajiwara N, Morii E, Aosaza K Flavell RA, Okumura K, Saito H and Nakae S.
Caspase-1, caspase-8 and calpain are dispensable for IL-33 release by macrophages.
J Immunol. 2009;183:7890-7897.
20Tanaka S, Yoshimoto T, Naka T, Nakae S, Iwakura Y, Cua D, and Kubo M。
Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses.
J Immunol. 2009;183:7523-7530.
21Harama D, Koyama K, Mukai M, Shimokawa N, Miyata M, Nakamura Y, Ohnuma Y, Ogawa H, Matsuoka S, Paton AW, Paton JC, Kitamura M, Nakao A.
A sub-cytotoxic dose of subtilase cytotoxin prevents LPS-induced inflammatory responses, depending on its capacity to induce the unfolded protein response.
J Immunol. 2009;183:1368-1374.
22Kato A, Chustz RT, Ogasawara T, Kulka M, Saito H, Schleimer RP, Matsumoto K.
Dexamethasone and FK506 inhibit distinct subsets of chemokines in human mast cells after cross-linking of FcεRI.
J Immunol. 2009;182:7233-7243.
23Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, Azuma M, Lee SK, Mizutani S, Morio T.
Impaired CD4 and CD8 T-cell effector function and decreased memory T-cell population in ICOS-deficient patients.
J Immunol. 2009;182:5515-5527.
24Nishida K, Hasegawa A Nakae S, Oboki K, Saito H, Yamasaki S and Hirano T.
Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction, but not the immediate-type reaction.
J Exp Med. 2009;206:1351-1364.
25Jiang J, Ymaguchi T, Funakushi N, Kuhara T, Fan PS, Ueki R, Suto H, Kase Y, Ikeda S, Ogawa H.
Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice.
J Dermatol Sci. 2009;56:37-42.
26Yang X, Sugita T, Takashima M, Hiruma M, Li R, Sudo H, Ogawa H, Ikeda S.
Differentiation of Trichophyton rubrum clinical isolates from Japanese and Chinese patients by randomly amplified polymorphic DNA and DNA sequence analysis of the non-transcribed spacer region of the rRNA gene.
J Dermatol Sci. 2009;54:38-42.
27Ng W, Nishiyama C, Mizoguchi M, Ikeda S, Okumura K, and Ogawa H.
Human umbilical cord epithelial cells express Notch ligands Delta1 and Jagged1.
J Dermatol Sci. 2009;54:131-134.
28Saeki H, Furue M, Furukawa F, Hide M, Ohtsuki M, Katayama I, Sasaki R, Suto H, Takehara K.
Guidelines for management of atopic dermatitis. The Journal of Dermatology.
J Dermatol. 2009;36:563-577.
29Yagami A, Inaba Y, Kuno Y, Suzuki K, Tanaka A, Sjolander S, Saito H, Matsunaga K.
Two cases of pollen-food allergy syndrome to soy milk diagnosed by skin prick test, specific serum immunoglobulin E and microarray analysis.
J Dermatol. 2009;36:50-55.
30Takahashi H, Toyoda M, Birumachi JI, Horie A, Uyama T, Miyado K, Matsumoto K, Saito H, Umezawa A.
Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta.
J Cell Physiol. 2009;221:335-342.
31Tatsumi K, Sou Y-S, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.
A novel type of E3-ligase for the Ufm1-conjugation system.
J Biol Chem. 2009;285:5417-5427.
32Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Vu AT, Kawasaki J, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H.
Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
J Allergy Clin Immunol. 2009;123:179-186.
33Takai T, Vu AT, Le AT, Kinoshita H, Ushio H, Ikeda S, Ogawa H, Okumura K.
Reply.
J Allergy Clin Immunol. 2009;124:864-865.
34Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K.
Notch signals confers antigen-presenting cell functions on mast cells.
J Allergy Clin Immunol. 2009;123:74-81.
35Enomoto Y, Orihara K, Takamasu T, Matsuda A, Gon Y, Saito H, Ra C, Okayama Y.
Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway following an acute asthma attack.
J Allergy Clin Immunol. 2009;124:913-920.
36Orihara K, Morita H, Yagami A, Kajiwara N, Nakae S, Matsumoto K, Nagasaki H, Saito Y, Saito H, Matsuda A.
TH2 cytokines potently induce an appetite-stimulating peptide, melanin-concentrating hormone, in human vascular endothelial cells.
J Allergy Clin Immunol. 2009;124:612-614.
37Ito T, Nishiyama C, Nakano N, Nishiyama M, Usui Y, Takeda K, Kanada S, Fukuyama K, Akiba H, Tokura T, Hara M, Tsuboi R, Ogawa H, Okumura K.
Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma.
Int Immunol. 2009;21:803-816.
38Sekine C, Moriyama Y, Koyanagi A, Koyama N, Ogata H, Okumura K, Yagita H.
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands.
Int Immunol. 2009;21:295-301.
39Sumi T, Ishida W, Mittler RS, Yagita H, Taguchi O, Fukushima A.
Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis.
Int Arch Allergy Immunol. 2009;148:305-310.
40Suzuki K, Kaminuma O, Yang L, Motoi Y, Takai T, Ichikawa S, Okumura K, Ogawa H, Mori A, Takaiwa F, Hiroi T.
Development of transgenic rice expressing mite antigen for a new concept of immunotherapy.
Int Arch Allergy Immunol. 2009;149 Suppl 1:21-24.
41Matsumoto K, Fukuda S, Nakamura Y, Saito H.
Amphiregulin production by human eosinophil.
Int Arch Allergy Immunol. 2009;149:39-44.
42Nagata S, Yamashiro Y, Ohtsuka Y, Shimizu T, Sakurai Y, Misawa S, Ito T.
Heat shock proteins and superantigenic properties of bacteria from the gastrointestinal tract of patients with Kawasaki disease.
Immunology. 2009;128:511-520.
43Potaczek D, Nishiyama C, Sanak M, Szczeklik A, and Okumura K.
Genetic variability of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha).
Immunol Res. 2009;45:75-84.
44Potaczek DP, Maeda K, Wang QH, Nakano N, Kanada S, Stepien E, Branicka A, Fukai T, Hara M, Tokura T, Ogawa H, Undas A, Okumura K, Nishiyama C.
FcepsilonRIalpha gene -18483A>C polymorphism affects transcriptional activity through YY1 binding.
Immunogenetics. 2009;61:649-655.
45Potaczek D, Maeda K, Wang Q-h, Nakano N, Kanada S, Stepien E, Branicka A, Fukai T, Hara M, Tokura T, Ogawa H, Undas A, Okumura K, and Nishiyama C.
FcepsilonRIalpha gene -18483 A>C polymorphism affects transcriptional activity through YY1 binding.
Immunogenetics. 2009;61:649-655.
46Ishigame H, Kakuta S, Nagai T, Kadoki M., Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C and Iwakura Y.
Differential roles of IL-17A and IL-17F in host defense against mucoepithelial bacterial infection and allergic responses.
Immunity. 2009;30:108-119.
47Ichikawa S, Takai T, Yashiki T, Takahashi S, Okumura K, Ogawa H, Kohda D, Hatanaka H.
Lipopolysaccharide binding of the mite allergen Der f 2.
Genes Cells. 2009;14:1055-1065.
48Nakamura Y, Miyata M, Shimokawa N,Ohnuma Y, Katoh R, Ogawa H, Okumura K, Nakao A.
House dust mite allergen Der f 1 can induce the activation of latent TGFbeta via its protease activity.
FEBS Lett. 2009; 583:2088-2092.
49Kametani Y, Suzuki D, Kohu K, Satake M, Suemizu H, Sasaki E, Ito T, Tamaoki N, Muzushima T, Ozawa M, Tani K, Kito M, Arai H, Koyanagi A, Yagita H, Habu S.
Development of monoclonal antibodies for analyzing immune and hematopoietic systems of common marmoset.
Exp Hematol. 2009;37:1318-1329.
50Ebihara N, Nakayama M, Tokura T, Ushio H, Murakami A.
Expression and function of fibroblast growth factor-inducible 14 in human corneal myofibroblasts.
Exp Eye Res. 2009;89:256-262.
51Makino H, Toyoda M, Matsumoto K, Saito H, Nishino K, Fukawatase Y, Machida M, Akutsu H, Uyama T, Miyagawa Y, Okita H, Kiyokawa N, Fujino T, Ishikawa Y, Nakamura T, Umezawa A.
Mesenchymal to embryonic incomplete transition of human cells by chimeric OCT4/3 (POU5F1) with physiological co-activator EWS.
Exp Cell Res. 2009;315:2727-2740.
52Okayama Y, Okumura S, Sagara H, Yuki K, Sasaki T, Watanabe N, Fueki M, Sugiyama K, Takeda K, Fukuda T, Saito H, Ra C.
FcεRI-mediated thymic stromal lymphopoietin production by IL-4-primed human mast cells.
Eur Respir J. 2009;34:425-435.
53Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, Okumura K, Ogawa H, Masuyama K, Nakao A.
Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation.
Eur J Immunol. 2009;39:3078-3083.
54Sato Y, Ohki Y, Akiyama H, Rosenkvist J, Gritli I, Okumura K, Ogawa H, Heissig B, Hattori K, Ohsaka A.
Targeted deletion of matrix metalloproteinase-9 reduces neutrophil accumulation during G-CSF-induced neoangiogenesis.
Cytometry Res. 2009;19:53-62.
55Niyonsaba F, Nagaoka I, Ogawa H, Okumura K.
Multifunctional antimicrobial proteins and peptides: natural activators of immune systems.
Curr Pharm Des. 2009;15:2393-413.
56Ebihara N, Nakayama M, Tokura T, Iwatsu M, Ushio H, Murakami A.
Proinflammatory effect of TWEAK/Fn14 interaction in human retinal pigment epithelial cells.
Curr Eye Res. 2009;34:836-844.
57Okumura S, Yuki K, Kobayashi R, Okamura S, Omori K, Saito H, Ra C, Okayama Y.
Hyperexpression of NOD2 in intestinal mast cells of Crohn's disease patients; preferential expression of inflammatory cell-recruiting molecules via NOD2 in mast cells.
Clin Immunol. 2009;130:175-185.
58Shimokawa N, Nishiyama C, Hirota T, Tamari M, Hara M, Ikeda S, Okumura K, Ogawa H.
Functional analysis of a polymorphism in the promoter region of the IL-12/23p40 gene.
Clin Exp Allergy. 2009;39:228-235.
59Morisawa Y, Kitamura A, Ujihara T, Zushi N, Kuzume K, Shimanouchi Y, Tamura S, Wakiguchi H, Saito H, Matsumoto K.
Effect of heat treatment and enzymatic digestion on the B cell epitopes of cow's milk proteins.
Clin Exp Allergy. 2009;39:918-925.
60Nagumo H, Abe J, Kano H, Taki S, Yamazaki K, Yamazaki T, Kobayashi N, Koike K, Sugane K, Saito H, Agematsu K.
Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways.
Cell Immunol. 2009;256:56-63.
61Tanaka K, Kon N, Ohkawa N, Yoshikawa N, Shimizu T.
Does breastfeeding in the neonatal period influence the cognitive function of very-low-birth-weight infants at 5 years of age?
Brain Dev. 2009;31:288-293.
62Sumi T, Ishida W, Okumura K, Yagita H, Fukushima A.
Activation of tumor necrosis factor-related apoptosis-inducing ligand receptor enhances the severity of murine allergic conjunctivitis.
Br J Ophthalmol. 2009;93:110-115.
63Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K.
The human antimicrobial peptide dermcidin activates normal human keratinocytes.
Br J Dermatol. 2009;160:243-249.
64Imada Y, Fujimoto M, Hirata K, Hirota T, Suzuki Y, Saito H, Matsumoto K, Akazawa A, Katsunuma T, Yoshihara S, Ebisawa M, Shibasaki M, Arinami T, Tamari M, Noguchi E.
Large scale genotyping study for asthma in the Japanese population.
BMC Res Notes. 2009;2:54.
65Nakayama M, Akiba H, Takeda K, Kojima Y, Hashiguchi M, Azuma M, Yagita H, Okumura K.
Tim-3 mediates phagocytosis of apoptotic cells and the cross-presentation.
Blood. 2009;113:3821-3830.
66Fukai T, Nishiyama C, Kanada S, Nakano N, Hara M, Tokura T, Ikeda S, Ogawa H, Okumura K.
Involvement of PU.1 in the transcriptional regulation of TNF-alpha.
Biochem Biophys Res Commun. 2009;388:102-106.
67Seto T, Takai T, Ebihara N, Matsuoka H, Wang XL, Ishii A, Ogawa H, Murakami A, Okumura K.
SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells.
Biochem Biobhys Res Commun. 2009;379:681-685.
68Wang XL, Takai T, Kamijo S, Gunawan H, Ogawa H, Okumura K.
NADPH oxidase activity in allergenic pollen grains of different plant species.
Biochem Biobhys Res Commun. 2009;387:430-434.
69Potaczek D, Nishiyama C, Undas A, and Okumura K.
Tissue factor genetic polymorphisms and haplotypes in Japanese population.
Atherosclerosis. 2009;207:344-345.
70Usui Y, Takeuchi M, Hattori T, Okunuki Y, Nagasawa K, Kezuka T, Okumura K, Yagita H, Akiba H, Goto H.
Suppression of experimental autoimmune uveoretinitis by regulatory dendritic cells in mice.
Arch Ophthalmol. 2009;127:514-519.
71Harada M, Hirota T, Jodo AI, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Yoshihara S, Ebisawa M, Saito H, Matsumoto K, Nakamura Y, Zieglerk SF, Tamari M.
Functional analysis of the polymorphisms of the TSLP gene in human bronchial epithelial cells.
Am J Respir Cell Mol Biol. 2009;40:368-374.
72Yoshioka M, Sagara H, Takahashi F, Harada N, Nishio K, Mori A, Ushio H, Shimizu K, Okada T, Ota M, Ito YM, Nagashima O, Atsuta R, Suzuki T, Fukuda T, Fukuchi Y, Takahashi K.
Role of multidrug resistance-associated protein 1 in the pathogenesis of allergic airway inflammation.
Am J Physiol Lung Cell Mol Physiol. 2009;296:L30-36.
73Onizawa M, Nagaishi T, Kanai T, Nagano KI, Oshima S, Nemoto Y, Yoshioka A, Totsuka T, Okamoto R, Nakamura T, Sakamoto N, Tsuchiya K, Aoki K, Ohya K, Yagita H, Watanabe M.
Signaling pathway via TNFa/NFkB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis.
Am J Physiol Gastrointest Liver Physiol. 2009;296:G850-859.
74Potaczek D, Okumura K, and Nishiyama C.
FCER1A genetic variability and serum IgE levels.
Allergy. 2009;64:1383.
75Kato T, Takai T, Fujimura T, Matsuoka H, Ogawa T, Murayama K, Ishii A, Ikeda S, Okumura K, Ogawa H.
Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes.
Allergy. 2009;64:1366-1374.
76Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H.
Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
Allergy. 2009;64:1231-1232.
77Yamaguchi M, Koketsu R, Suzukawa M, Kawakami A, Iikura M.
Human basophils and cytokines/chemokines.
Allergol Int. 2009;58:1-10.
78Fujisawa T, Nagao M, Hiraguchi Y, Hosoki K, Tokuda R, Usui S, Masuda S, Shinoda M, Hashiguchi A, Yamaguchi M.
Biomarkers for allergen immunotherapy in cedar pollinosis.
Allergol Int. 2009;58:163-170.
79Takai T, Ochiai Y, Ichikawa S, Sato E, Ogawa T, Tokura T, Kuhara T, Kawai H, Hatanaka H, Takakhashi S, Ogawa H, Okumura K.
Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: Useful tool for study of allergies in mouse models.
Allergol Int. 2009;58:225-235.
80Kashiwakura JI, Kawakami Y, Yuki K, Zajonc DM, Hasegawa S, Tomimori Y, Caplan B, Saito H, Furue M, Oettgen HC, Okayama Y, Kawakami T.
Polyclonal IgE Induces Mast Cell Survival and Cytokine Production.
Allergol Int. 2009;58:411-419.
81Fukagawa K, Okada N, Fujishima H, Nakajima T, Takano Y, Tanaka M, Dogru M, Satake Y, Tsubota K, Saito H.
Corneal and conjunctival fibroblasts are major sources of eosinophil-recruiting chemokines.
Allergol Int. 2009;58:499-508.

英文原著(2008年)

1Kohu K, Yamabe E, Matsuzawa A, Onda D, Suemizu H, Sasaki E, Tanioka Y, Yagita H, Suzuki D, Kametani Y, Takai T, Toyoda A, Habu S, Satake M.
Comparison of 30 immunity-related genes from the common marmoset with orthologues from human and mouse.
Tohoku J Exp Med. 2008;215:167-180.
2Wako M, Ohba T, Ando T, Arai Y, Koyama K, Hamada Y, Nakao A, Haro H.
Mechanism of signal transduction in TWEAK-induced matrix degradation by MMP-3 up-regulation in disc tissues.
Spine. 2008;33:2489-2494.
3Kamijo S, Nakajima A, Kamata K, Kurosawa H, Yagita H, Okumura K.
Involvement of TWEAK/Fn14 interaction in the synovial inflammation of RA.
Rheumatology. 2008;47:442-450.
4Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K.
ATP drives lamina propria TH17 cell differentiation.
Nature. 2008;455:808-812.
5Hirose N, Suganami M, Shiraki Y, Hiruma M, Ogawa H.
Management and follow-up survey of Trichophyton tonsurans infection in a university judo club.
Mycoses. 2008;51:243-247.
6Suzukawa M, Koketsu R, Iikura M, Nakae S, Matsumoto K, Nagase H, Saito H, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M.
Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils.
Lab Invest. 2008;88:1245-1253.
7Funaki T, Ebihara N, Murakami A, Nakao A.
Ex vivo transfer of Smad7 decreases damage to the corneal endothelium after penetrating keratoplasty.
Jpn J Ophthalmol. 2008;52:204-210.
8Fang Y, Sharp GC, Yagita H, Braley-Mullen H.
A critical role for TRAIL in resolution of granulomatous experimental autoimmune thyroiditis.
J Pathol. 2008;216:505-513.
9Oishi K, Baba T, Nakatomi Y, Ito T, and Hiramatsu K.
A Latex Agglutination Assay for Specific Detection of Panton-Valentine Leukocidin.
J Microbiol Methods. 2008;75:411-415.
10Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, Yamamaoto Y, Tadokoro T, Okumura K, Ogawa H.
Inhibitory Effect of Honeybee-Collected Pollen on Mast Cell Degranulation in vivo and in vitro.
J Medicinal Food. 2008;11:14-20.
11Takagi A, Nishiyama C, Maeda K, Kawada H, Kanada S, Niwa Y, Nakano N, Mayuzumi N, Nishiyama M, Ikeda S, Okumura K, Ogawa H.
Role of Sp1 in transcription of human ATP2A2 gene in keratinocytes.
J Invest Dermatol. 2008;128:96-103.
12Koketsu R, Suzukawa M, Kawakami A, Komiya A, Ra C, Yamamoto K, Yamaguchi M.
Activation of basophils by stem cell factor: comparison with insulin-like growth factor-I.
J Invest Allerg Clin Immunol. 2008;18:293-299.
13Suzukawa M, Iikura M, Koketsu R, Nagase H, Tamura C, Komiya A, Nakae S, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M.
An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor.
J Immunol. 2008;181:5981-5989.
14Hamada S, Umemura M, Hiono T, Tanaka K, Yahagi A, Begum MD, Oshiro K, Okamoto Y, Watanabe H, Kawakami K, Roark C, Born WK, O’Brien R, Ikuta K, Ishikawa H, Nakae S, Iwakura Y, Ohta T and Matsuzaki G.
IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver.
J Immunol. 2008;181:3456-3463.
15Kanada S, Nakano N, Potaczek D, Maeda K, Shimokawa N, Niwa Y, Fukai T, Sanak M, Szczeklik A, Yagita H, Okumura K, Ogawa H, and Nishiyama C.
Two different transcription factors discriminate the -315C>T-polymorphism of the FcepsilonRIalpha gene: Binding of Sp1 to -315C and of a high mobility group-related molecule to -315T.
J Immunol. 2008;180:8204-8210.
16Nagashima O, Harada N, Usui Y, Yamazaki T, Yagita H, Okumura K, Takahashi K, Akiba H.
B7-H3 contributes to the development of pathogenic Th2 cells in a murine model of asthma.
J Immunol. 2008;181:4062-4071.
17Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, Zuklys S, Holländer GA, Shima DT, Habu S.
Delta-like 4 is indispensable in thymic environment specific for T cell development.
J Exp Med. 2008;205:2507-2513.
18Zabel BA, Nakae S, Zunigav L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Galli SJ, Butcher EC.
Mast Cell-Expressed Orphan Receptor CCRL2 Binds Chemerin and is Required for Optimal Induction of IgE-Mediated Passive Cutaneous Anaphylaxis.
J Exp Med. 2008;205:2207-2220.
19Niyonsaba F, Hattori F, Maeyama K, Ogawa H, Okamoto K.
Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes.
J Dermatol Sci. 2008;52:216-219.
20Ng W, Nishiyama C, Mizoguchi M, Nakano N, Suga Y, Ikeda S, Itoh S, Kinoshita K, Okumura K, Ogawa H.
Human umbilical cord epithelial cells express Notch1: Implications for its epidermal-like differentiation.
J Dermatol Sci. 2008;49:143-152.
21Jamaluddin TZ, Kuwahara-Arai K, Hisata K, Terasawa M, Cui L, Baba T, Sotozono C, Kinoshita S, Ito T, Hiramatsu K.
Extreme genetic diversity of methicillin-resistant Staphylococcus epidermidis strains disseminated among healthy Japanese children
J Clin Microbiol. 2008;46:3778-3783.
22Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama J, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H.
Fusion of One twenty-two to BSAC results in aberrant upregulation of transcriptional activity.
J Biol Chem. 2008;283:26820-26828.
23Nakamura Y, Miyata M, Ohba T, Ando T, Hatsushika K, Suenaga F, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.
Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation.
J Allergy Clin Immun. 2008;122:1208-1214.
24Potaczek D, Sanak M, Nishiyama C, Okumura K, Ogawa H, Szkzeklik A.
FCER1A gene proximal promoter polymorphisms in Caucasians and East Asians.
Int J Immunogenet. 2008;35:339-340.
25Ohno S, Sato T, Kohu K, Takeda K, Okumura K, Satake M, Habu S.
Runx proteins are involved in regulation of CD122, Ly49 family and IFN-gamma expression during NK cell differentiation.
Int Immunol. 2008;20:71-79.
26Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M.
Evaluation of the effect of human beta-defensins on neutrophil apoptosis.
Int Immunol. 2008;20:543-553.
27Moriyama Y, Sekine C, Koyanagi A, Koyama N, Ogata H, Chiba S, Hirose S, Okumura K, Yagita H
Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice.
Int Immunol. 2008;20:763-773.
28Ito A, Shimura H, Nitahara A, Tomiyama K, Ito M, Kanekura T, Okumura K, Yagita H, and Kawai K.
NK cells contribute to the skin graft rejection promoted by CD4+ T cells activated through the indirect allorecognition pathway.
Int Immunol. 2008;20:1343-1349.
29Kawakami A, Koketsu R, Suzukawa M, Nagao M, Hiraguchi Y, Tokuda R, Fujisawa T, Nagase H, Ohta K, Yamamoto K, Yamaguchi M.
Blocking antibody is generated in allergic rhinitis patients during specific immunotherapy using standardized Japanese cedar pollen extract.
Int Arch Allergy Immunol. 2008;146(suppl 1):54-60.
30Nagao M, Noma-Hiraguchi Y, Hosoki K, Tokuda R, Usui T, Masuda S, Yamaguchi M, Fujisawa T.
Allergen-induced basophil CD203c expression as a biomarker for rush immunotherapy in patients with Japanese cedar pollinosis.
Int Arch Allergy Immunol. 2008;146(suppl 1):47-53.
31Gunawan H, Takai T, Kamijo S, Wang XL, Ikeda S, Okumura K, Ogawa H.
Characterization of proteases, proteins, and eicosanoid-like substances in soluble extracts from allergenic pollen grains.
Int Arch Allergy Immunol,. 2008;147:276-288.
32Nakano N, Nishiyama C, Tokura T, Nagasako-Akazome Y, Ohtake Y, Okumura K, Ogawa H.
Procyanidin C1 from apple extracts inhibits FcepsilonRI-mediated mast cell activation.
Int Arch Allergy Immunol. 2008;147:213-221.
33Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Okumura K, Akiba H, Yagita H, Ueno H.
Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice.
Int Arch Allergy Immunol. 2008;146:36-43.
34Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H.
Upregulation of release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1.
Int Arch Allergy Immunol. 2008;146:27-35.
35Saito Y, Miyagawa Y, Onda K, Nakajima H, Sato B, Horiuchi Y, Okita H, Katagiri YU, Saito M, Shimizu T, Fujimoto J, Kiyokawa N.
B-cell-activating factor inhibits CD20-mediated and B-cell receptor-mediated apoptosis in human B cells.
Immunology. 2008;125:570-590.
36Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H.
Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation.
Immunology. 2008;124:357-367.
37Iwakura Y, Nakae S, Saijo S and Ishigame H.
The roles of IL-17A in inflammatory immune responses and host defense against pathogens.
Immunol Rev. 2008;226:57-79.
38Sheng Y, Yahata T, Negishi N, Nakano Y, Habu S, Hozumi K, Ando K.
Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development.
Immunol Lett. 2008;121:33-37.
39Fukushima A, Sumi T, Ishida W, Ojima A, Kajisako M, Koyanagi A, Koyama N, Yagita H.
Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis.
Immunol Lett. 2008;121:140-147.
40Ito R, Maekawa S, Kawai K, Suemizu H, Suzuki S, Ishii H, Tanioka Y, Satake M, Yagita H, Habu S, Ito M.
Novel monoclonal antibodies recognizing different subsets of lymphocytes from the common marmoset (Callithrix jacchus).
Immunol Lett. 2008;121:116-122.
41Kametani Y, Wang L, Koduka K, Sato T, Katano I, Habu S.
Rapid histone deacetylation and transient HDAC association in the IL-2 promoter region of TSST-1-stimulated T cells.
Immunol Lett. 2008;119:97-102.
42Sumi T, Ishida W, Ojima A, Kajisako M, Sakanishi T, Yagita H, Fukushima A.
CD27 and CD70 do not play a critical role in the development of experimental allergic conjunctivitis in mice.
Immunol Lett. 2008;119:91-96.
43Wang QH, Nishiyama C, Nakano N, Shimokawa N, Hara M, Kanada S, Ogawa H, and Okumura K.
Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells.
Immunogenetics.2008;60:557-563.
44Itoh Y, Nishida C, Tokiwa N, Satoh K, Tokura T, Maeda K.
The determination of Lewis and secretor-nonsecretor functional alleles for clinical application of urinary CA19-9.
Forensic Science International : Genetics Supplement Series. 2008;1:565-556.
45Suenaga F, Hatsushika K, Takano S, Ando T, Ohnuma Y, Ogawa H, Nakao A.
A possible link between resveratrol and TGF-β: resveratrol induction of TGF-β expression and signaling.
FEBS Lett. 2008;582:586-590.
46Hozumi K, Negishi N, Tsuchiya I, Abe N, Hirano K, Suzuki D, Yamamoto M, Engel JD, Habu S.
Notch signaling is necessary for GATA3 function in the initiation of T cell development.
Eur J Immunol. 2008;38:977-985.
47Miyata M, Hatsushika K, Ando T, Shimokawa N, Ohnuma Y, Katoh R, Suto H, Ogawa H, Masuyama K, Nakao A.
Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis.
Eur J Immunol. 2008;38:1487-1492.
48Nakae S, Oboki K and Saito H.
Mast cells and T-cell expansion.
Blood. 2008;111:2497.
49Komatsu M, Tajima Y, Ito T, Yamashiro Y, Hiramatsu K.
Time-suppression test using a colorimetric probe (alamarBlue) that measures bacterial metabolic activity.
Biomed Res. 2008;29:171-173.
50Niwa Y, Nishiyama C, Nakano N, Kamei A, Kato H, Kanada S, Ikeda S, Ogawa H, and Okumura K.
Opposite effects of PU.1 on mast cell stimulation.
Biochem Biophys Res Commun. 2008;375:95-100.
51Takano S, Ando T, Hiramatsu N, Kanayama A, Maekawa S, Ohnuma Y, Enomoto N, Ogawa H, Paton AW, Paton JC, Kitamura M, Nakao A.
T cell receptor-mediated signaling induces GRP78 expression in T cells: The implications in maintaining T cell viability.
Biochem Biophys Res Commun. 2008;371:762-766.
52Matsumoto K, Fukuyama S, Eguchi-Tsuda M, Nakano T, Matsumoto T, Matsumura M, Moriwaki A, Kano K, Wada Y, Yagita H, Shin T, Pardoll DM, Patcharee R, Azuma M, Nakanishi Y, Inoue H.
B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma.
Biochem Biophys Res Commun. 2008;365:170-175.
53Jayawardana TMS, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H.
Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis.
Biochem Biophys Res Commun. 2008;365:137-142.
54Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Katoh R, Ogawa H, Hamada Y, Nakao A.
A potential role of TSLP in the recruitment of macrophages to the intervertebral disc via MCP-1 induction:The implications in a herniated disc.
Arthritis and Rheumatism. 2008;58:3510-351.
55Potaczek D, Nishiyama C, Sanak M, Szczeklik A, Okumura K, and Ogawa H.
FCER1A gene exon 1A polymorphisms in Japanese and Polish subjects - a comparative analysis of haplotypes.
Allergy. 2008;63:626-627.
56Gunawan H, Takai T, Ikeda S, Okumura K, Ogawa H.
Protease activity of allergenic pollen of cedar, cypress, juniper, birch, and ragweed.
Allergol Int. 2008;57:83-91.
57Oboki K, Ohno T, Saito H and Nakae S.
Th17 and Allergy.
Allergol Int. 2008;57:121-134.

英文原著(2007年)

1Ebihara N, Chen L, Tokura T, Ushio H, Iwatsu M, Murakami A.
Distinct functions between Toll-like receptors 3 and 9 in retinal pigmnet epithelial cells.
Ophthalmic Res. 2007;39:155-163.
2Ozawa T, Koyama K, Ando T, Ohnuma Y, Hatsushika K, Ohba T, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A.
TSLP secretion of synovial fibroblasts is positively and negatively regulated by TLRs/NF-kB pathway and IFN-g/dexamethasone.
Modern Rheumatology. 2007;17:459-463.
3Koyama K, Hatsushika K, Ando T, Sakuma M, Wako M, Kato R, Sugiyama H, Hamada Y, Ogawa H, Nakao A.
Imatinib mesylate both prevents and treats the arthritis induced by type II collagen antibody in mice.
Modern Rheumatology. 2007;17:306-310.
4Iikura M, Suto H, Okayama Y, Saito H, Galli SJ, Nakae S.
IL-33, but not IL-18, can promote survival, adhesion and cytokine production in human mast cells.
Lab Invest. 2007;87:971-978.
5Wako M, Haro H, Ando T, Hatsushika K, Ohba T, Iwabuchi S, Nakao A, Hamada Y.
Novel function of TWEAK in inducing intervertebral disc degeneration.
J Orthop Res. 2007;25:1438-1446.
6Nakae S, Iwakura Y, Suto H, Galli SJ.
Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17.
J Leukoc Biol. 2007;81:1258-1268.
7Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana STM, Ikeda S, Okumura K, Ogawa H.
The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor4.
J Leuko Biol. 2007;82:657-665.
8Ho LH, Ohno T, Suto H, Iikura M, Akira S, Okayama Y, Saito H, Galli SJ and Nakae S.
IL-33 induces IL-13 production by mouse mast cells independent of IgE-FcepsilonRI signals.
J Leuko Biol. 2007;82:1481-1490.
9Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H.
Antimicrobial peptides human b-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines.
J Invest Dermatol. 2007;127:594-604.
10Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, and Tada N.
Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1α transgenic mice due to GM-CSF overproduction.
J Immunol. 2007;179:639-646.
11Haruna K, Suga Y, Mizuno Y, Kourou K, Muramatsu S, Hasegawa T, Inoue A, Ogawa H, Ikeda S, Lakhmiri M, Seto A.
A Moroccan patient with Sjögren-Larsson syndrome.
J Dermatol. 2007;34:153-155.
12Hasegawa T, Sumiyoshi K, Tsuchihashi H, Ikeda S, Nakao A, Ogawa H.
FK506 inhibits the enhancing effects of TGF-beta on wound healing in a rabbit dermal ulcer model.
J Dermatol Sci. 2007;47:37-40.
13Jiang J, Kuhara T, Ueki R, Zheng Y, Suto H, Ikeda S, Ogawa H.
Inhibitory effects of paroxetine on the development of atopic dermatitis-like lesions in NC/Nga mice.
J Dermatol Sci. 2007;47:244-247.
14Tsuchihashi H, Hasegawa T, Sumiyoshi K, Ogawa H, Ikeda S, Ando T, Nakao A, Okumura K.
TWEAK inhibits TGF-beta-induced contraction of normal and keloid fibroblast-embedded collagen gel.
J Dermatol Sci. 2007;45:216-218.
15Ng W, Kikuchi Y, Chen X, Hira K, Ogawa H, Ikeda S.
Pseudocysts of the auricle in a young adult with facial and ear atopic dermatitis.
J Biochem. 2007;141:345-351.
16Nakae S, Ho LH, Yu M, Monteforte R, Iikura M, Suto H, Galli SJ.
Mast cell-derived TNF contributes to airway hyperreactivity,inflammation, and T(H)2 cytokine production in an asthma model in mice.
J Allergy Clin Immunol. 2007;120:48-55.
17Ando T, Hatsushika K, Wako M, Ohba T, Koyama K, Ohnuma Y, Katoh R, Ogawa H, Okumura K, Luo J, Wyss-Coray T, Nakao A.
Orally administered TGF-βis biologically active in the intestinal mucosa and enhances oral tolerance.
J Allergy Clin Immun. 2007;120:916-923.
18Ebihara N, Yamagami S, Chen L, Tokura T, Iwatsu M, Ushio H, Murakami A.
Expression and function of Toll-like receptor-3 and -9 in human corneal myofibroblasts.
Invest Ophthalmol & Vis Science. 2007;48:3069-3076.
19Sakuma M, Hatsushika K, Koyama K, Katoh R, Ando T, Watanabe Y, Wako M, Kanzaki M, Takano S, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A.
TGF-βtype I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody.
Int Immunol. 2007;19:117-26.
20Kanzaki M, Shibagaki N, Hatsushika K, Mitsui H, Inozume T, Okamoto A, Dobashi Y, Ogawa H, Shimada S, Nakao A.
Human eosinophils have an intact Smad signaling pathway leading to a major transforming growth factor-beta target gene expression.
Int Arch Allergy Imm. 2007;142:309-317.
21Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H.
Antimicrobial peptides human b-defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability.
Eur J Immunol. 2007;37:434-444.
22Hatsushika K, Hirota T, Harada M, Sakashita M, Kanzaki M, Takano S, Doi S, Fujita K, Enomoto T, Ebisawa M, Yoshihara S, Sagara H, Fukuda T, Masuyama, Katoh R, Matsumoto K, Saito H, Ogawa H, Tamari M, Nakao A.
Transforming Growth Factor-β2 polymorphisms are associated with childhood atopic asthma.
Clin Exp Allergy. 2007;37:1165-1174.
23Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H.
Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human a-defensins from neutrophils.
Br J Dermatol. 2007;157:1124-31.
24Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH and Galli SJ.
TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.
Blood. 2007;110:2565-2568.
25Nakano N, Nishiyama C, Kanada S, Niwa Y, Shimokawa N, Ushio H, Nishiyama M, Okumura K, Ogawa H.
Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections.
Blood. 2007;109:4846-4855.
26Nakae S, Suto H, Berry GJ, Galli SJ.
Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice.
Blood. 2007;109:3640-3648.
27Koyama K, Ozawa T, Hatsushika K, Ando T, Takano S, Wako M, Suenaga F, Ohnuma Y, Ohba T, Katoh R, Sugiyama H, Hamada Y, Ogawa H, Okumura K, Nakao A.
A possible role for TSLP in inflammatory arthritis.
Biochem Biophys Res Commun. 2007;357:99-104.
28Momose S, Kobayashi T, Tada N, Itoyama S, Hino O.
N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo.
Biochem Biophys Res Commun. 2007;356:693-698.

英文原著(2006年)

1Nakamura T, Hirasawa Y, Takai T, Mitsuishi K, Okuda M, Kato T, Okumura K, Ikeda S, Ogawa H.
Reduction of skin barrier function by proteolytic activity of a recombinant house dust mite allergen Der f 1.
J Invest Dermatol. 2006;126:2719-2723.
2Kikuchi Y, Takai T, Kuhara T, Ota M, Kato T, Hatanaka H, Ichikawa S, Tokura T, Akiba H, Mitsuishi K, Ikeda S, Okumura K, Ogawa H.
Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p 1 to sensitization towards IgE and IgG responses.
J Immunol. 2006;177:1609-1617.
3Suto H, Nakae S, Kakurai M, Sedwick JD, Tsai M, Galli SJ.
Mast cell-associated TNF promotes dendritic cell migration.
J Immunol. 2006;176:4102-112.
4Nakae S, Suto H, Iikura M, Kakurai M, Sedgwick JD, Tsai M, Galli SJ.
Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF.
J Immunol. 2006;176:2238-2248.
5Mizuno Y, Suga Y, Hasegawa T, Haruna K, Kohroh K, Ogawa H, Ikeda S, Shimizu T, Komatsu N.
A case of peeling skin syndrome successfully treated with topical calcipotriol.
J Dermatol. 2006;33:430-432.
6Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H.
Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells.
J Dermatol Sci. 2006;43:63-66.
7Ng W, Mizoguchi M, Nishiyama C, Suga Y, Ogawa H, Ikeda S.
Human umbilical cord epithelial cells express epidermal keratins and cornified envelope proteins, and show epidermal-like differentiation and morphogenesis in vitro and in vivo.
J Dermatol Sci. 2006;42:153.
8Shiraki Y, Hiruma M, Matsuba Y, Kano R, Makimura K, Ikeda S, Ogawa H.
A case of tinea corporis caused by Arthroderma benhamiae (teleomorph of Tinea mentagrophytes) in a pet shop employee.
J Am Acad Dermatol. 2006;55:153-154.
9Itoh Y, Satoh K, Takahashi K, Maeda K, Tokura T, Kobayashi R.
Evaluation of Lewis genotyping by four PCR-based methods.
International Congress Series. 2006;1288:819-821.
10Kikuchi Y, Takai T, Ota M, Kato T, Takeda K, Mitsuishi K, Ikeda S, Okumura K, Ogawa H.
Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin.
Int Arch Allergy Immunol. 2006;141:322-330.
11Takai T, Mizuuchi E, Kikuchi Y, Nagamune T, Okumura K, Ogawa H.
Glycosylation of recombinant proforms of major house dust mite allergens Der p 1 and Der f 1 decelerates the speed of maturation.
Int Arch Allergy Immunol. 2006;139:181-187.
12Niyonsaba F, Nagaoka I, Ogawa H.
Human degensins and cathelicidins in the skin: beyond direct antimicrobial properties.
Crit Rev Immunol. 2006;26:545-576.
13Mizuno Y, Suga Y, Haruna Y, Muramatsu S, Hasegawa T, Kohroh K, Shimizu T, Komatsu N, Ogawa H, Ikeda S.
A case of a Japanese neonate with congenital ichthyosiform erythroderma diagnosis as Netherton syndrome.
Clin Exp Dermatol. 2006;31:677-680.
14Maeda K, Nishiyama C, Tokura T, Nakano H, Kanada S, Nishiyama M, Okumura K, and Ogawa H.
FOG-1 represses GATA-1-dependent Fc epsilon RI beta-chain transcription:transcriptional mechanism of mast cell-specific gene expression in mice.
Blood. 2006;108:262-268.
15Nishiyama C.
Molecular mechanism of allergy-related gene regulation and hematopoietic cell development by transcription factors.
Biosci Biotechnol Biochem. 2006;70:1-9.
16Takagi A, Nishiyama C, Kanada S, Niwa Y, Fukuyama K, Ikeda S, Okumura K,Ogawa H.
Prolonged MHC class II expression and CIITA transcription in human keratinocytes.
Biochem Biophys Res Commun. 2006;347:388-393.
17Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H and Nakao A.
TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells.
Arthritis Res Ther. 2006;8:R146.
18Kakurai M, Monteforte R, Suto H, Tsai M, Nakae S and Galli SJ. .
Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice.
Am J Pathol. 2006;169:1713-1721.
19Yokoi H, Okayama Y, Niyonsaba F, Fujimori M, Enomoto F, Yoshikawa H, Ikeda K, Saito H.
Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors.
Allergy Asthma Proc. 2006;27:415-421.

英文原著(2005年)

1Nakae S, Suto H, Kakurai M, Sedgwick JD, Tsai M, Galli SJ.
Mast cells enhance T cell activation: Importance of mast cell-derived TNF.
Proc Natl Acad Sci USA. 2005;102:6467-6472.
2Aoki Y, Kogawa M, Ichimura S, Kikuchi T, Tada N, Fujikawa K.
Overexpression of the human interleukin-1 alpha gene causes osteopenia in mice.
J Rheumatol. 2005;32:320-324.
3Lee K D, Yamataka A, Kato Y, Kobayashi H, Lane G J, Maeda K, Kojima Y, Sueyoshi N, and Miyano T.
Graft serosectomy in adult small bowel transplantation without vascular reconstruction in rats improves graft survival by induction of vascular endothelial growth factor.
J Pediatr Surg. 2005;40:1881-1886.
4Kawada H, Nishiyama C, Takagi A, Tokura T, Nakano N, Maeda K, Mayuzumi N, Ikeda S, Okumura K, and Ogawa H.
Transcriptional regulation of ATP2C1 gene by Sp1 and YY1 and reduced function of its promoter in Hailey-Hailey disease keratinocytes.
J Invest Dermatol. 2005;124:1206-1214.
5Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H.
The human beta-defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 kinase and ERK MAPK activation in primary human keratinocytes.
J Immunol. 2005;175:1776-1784.
6Kanamaru Y, Sumiyoshi K, Ushio H, Ogawa H, Okumura K, Nakao A.
Smad3 deficiency in mast cells provides efficient host protection against acute septic peritonitis.
J Immunol. 2005;174:4193-4197.
7Ito T, Nishiyama C, Nishiyama M, Matsuda H, Maeda K, Akizawa Y, Tsuboi R, Okumura K, and Ogawa H.
Mast cells acquire monocyte-specific gene expression and monocyte-like morphology by overproduction of PU.1.
J Immunol. 2005;174:376-383.
8Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Ogawa H, Werb Z, Hattori K.
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization.
J Exp Med. 2005;202:739-750.
9Ju Jiang, Tsuboi R, Kojima Y, Ogawa H.
Topical application of ketoconazole stimulated hair growth in C3H/HeN mice.
J Dermatol. 2005;32:243-247.
10Ogawa K, Ito M, Takeuchi K, Nakada A, Heishi M, Suto H, Mitsuishi K, Sugita Y, Ogawa H, Ra C.
Tenascin-C is upregulated in the skin lesions of patients with atopic dermatitis.
J Dermatol Sci. 2005;40:35-41.
11Niyonsaba F, Ogawa H.
Protective roles of the skin against infection: Implication of naturally occurring human antibacterial agentsβ-defensins, cathelicidin LL-37 and lysozyme.
J Dermatol Sci, 40:157-168.
12Porgpermdee S, Yu X, Takagi A, Mayuzumi N, Ogawa H, Ikeda S.
Expression of SPCA1 (Hailey-Hailey disease gene product) in acantholytic dermatoses.
J Dermatol Sci. 2005;40:137-140.
13Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H.
Synergistic effect of antibacterial agents human beta-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli.
J Dermatol Sci. 2005;40:12-32.
14Hasegawa T, Nakao A, Sumiyoshi K, Tsuchihashi H, Ogawa H.
SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts.
J Dermatol Sci. 2005;39:33-38.
15Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H.
The effect of antibacterial peptide human beta-defensin-2 on interleukin-18 secretion by keratinocytes.
J Dermatol Sci. 2005;37:188-191.
16Muramatsu S, Suga Y, Mizuno Y, Haseagawa T, Matsuba S, Hashimoto Y, Jurgen Seitz, Alfred, Ogawa H.
Differentiation specific localization of catalase and hydrogen peroxide, and their alterations in rat skin exposed to ultraviolet B rays.
J Dermatol Sci. 2005;37:151-158.
17Ichikawa S, Takai T, Inoue T, Yuuki T, Okumura Y, Ogura K, Inagaki F, Hatanaka H.
NMR study on the major mite allergen Der f 2: Its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members.
J Biochem. 2005;37:255-263.
18Kato T, Takai T, Mitsuishi K, Okumura K, Ogawa H.
Cystatin A inhibits IL-8 production by keratinocytes stimulated with Der p 1 and Der f 1: Biochemical skin-barrier against mite cysteine proteases.
J Allergy Clin Immunol. 2005;116:169-176.
19Takai T, Kato T, Yasueda H, Okumura K, Ogawa H.
Analysis of the structure and allergenicity of recombinant pro- and mature Der p 1 and Der f 1: Major conformational IgE-epitopes blocked by prodomains.
J Allergy Clin Immunol. 2005;115:555-563.
20Nishiyama C, Ito T, Nishiyama M, Masaki S, Maeda K, Nakano N, Ng W, Fukuyama K, Yamamoto M, Okumura K, Ogawa H.
GATA-1 is required for expression of Fc epsilon RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow.
Int Immunol. 2005;17:847-856.
21Okamoto A, Kawamura T, Kanbe K, Kanamaru Y, Ogawa H, Okumura K, Nakao A.
Suppression of serum IgE response and systemic anaphylaxis in a food allergy model by orally administered high-dose TGF-beta.
Int Immunol. 2005;17:705-712.
22Takai T, Kato T, Ota M, Yasueda H, Kuhara T, Okumura K, Ogawa H.
Recombinant Der p 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25, and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice.
Int Arch Allergy Immunol. 2005;137:194-200.
23Takai T, Takaoka M, Yasueda H, Okumura K, Ogawa H.
Dilution-method to refold bacterially expressed recombinant Der f 2 and Der p 2 to exhibit the secondary structure and histamine-releasing activity of natural allergens.
Int Arch Allergy Immunol. 2005;137:1-8.
24Miyahira Y., Takashima Y, Kobayashi S, Matsumoto Y, Takeuchi T, Ohyanagi-Hara M, Yoshida A, Ohwada A, Akiba H, Yagita H, Okumura K and Ogawa H.
Immune responses against a single CD8+ T cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection.
Infect Immun. 2005;73:7356-7365.
25Nakano N, Nishiyama C, Masuoka N, Nishiyama M, Yamane H, Okumura K, Ogawa H.
Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA.
Immunogenetics. 2005;56:871-877.
26Heissig B, Ohki Y, Sato Y, Rafii S, Werb Z, Hattori K..
A role for niches in hematopoietic cell development.
Hematology. 2005;10:247-253.
27Nakazawa T, Takai T, Hatanaka H, Mizuuchi E, Nagamune T, Okumura K, Ogawa H.
Multiple-mutation at a potential ligand-binding region decreased allergenicity of a mite allergen Der f 2 without disrupting global structure.
FEBS Lett. 2005;579:1988-1994.
28Ohki Y, Heissig B, Sato Y, Akiyama H, Zhu Z, Hicklin DJ, Shimada K, Ogawa H, Daida H, Hattori K, Ohsaka A.
Granulocyte colony-stimulating factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils.
FASEB J. 2005;19:2005-2007.
29Inoue A, Ikeda S, Mizuno Y, Ogawa H.
Superficial Mucoceles of the Soft Palate.
Dermatology. 2005;210:360-362.
30Mitsuishi K, Nakamura T, Sakata Y, Yuyama N, Arima K, Sugita Y, Suto H,Izuhara K, Ogawa H.
The squamous cell carcinoma antigens as relevant biomarkers of atopic dermatitis.
Clin Exp Allergy. 2005;35:1327-1333.
31Nakano N, Ishidoh K, Nakao A, Tsuboi R, Kominami E, Okumura K, Ogawa H.
CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes.
Br J Dermatol. 2005;153:37-45.
32Muramatsu S, Suga Y, Mizuno Y, Hasegawa T, Komuro Y, Kubo Y, Imakado S, Ogawa H.
A Japanese case of naevoid basal cell carcinoma syndrome associated with segmental vitiligo.
Br J Dermatol. 2005;152:812-814.
33Muramatsu S, Suga Y, Mizuno Y, Hasegawa T, Tsuchihashi H, Matsuba S, Kohroh K, Yaguchi H, Ogawa H.
A novel threonine to proline mutation in the helix termination motif of keratin 1 in epidermolytic hyperkeratosis with severe palmoplantar hyperkeratosis and contractures of the digits.
Br J Dermatol. 2005;152:1087-1089.
34Tokura T, Nakano N, Ito T, Matsuda H, Akazome Y, Kanda T, Ikeda M, Okumura K, Ogawa H, Nishiyama C.
Inhibitory effect of polyphenol-enriched apple extract on mast cell degranulation in vitro targeting the binding between IgE and Fc epsilon RI.
Biosci Biotechnol Biochem. 2005;69:1974-1977.
35Nakano N, Nakao A, Uchida T, Shirasaka N, Yoshizumi H, Okumura K, Tsuboi R, Ogawa H.
Effects of arachidonic acid analogs on FceRI-mediated activation of mast cells.
Biochim Biophys Acta. 2005;1738:19-28.
36Takai T, Kato T, Sakata Y, Yasueda H, Izuhara K, Okumura K, Ogawa H.
Recombinant Der p 1 and Der f 1 exhibit cysteine protease activity but no serine protease activity.
Biochem Biophys Res Commun. 2005;328:944-952.
37Titapiwatanakun B, Miyahira Y, Mayuzumi N, Ogawa H. and Ikeda S.
SCCA2 transfected human keratinocytes show increased secretion of IL-1β and IL-6, but not of TNF-α.
Arch Dermatol Res. 2005;297:274-277.
38Yu X, Ikeda S, Yaguchi H, Ogawa H, Uchida T, Lysvand H, Iversen OJ.
An anti-pso p27 monoclonal antibody reacts with skin and peripheral blood leukocytes from Japanese psoriatic patients and shows cross-reactivity with SCCA2b.
Arch Dermatol Res. 2005;296:372-374.