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学校法人順天堂@juntendo1838
スポーツ健康科学部@juntendo_sakura
練馬病院@juntendo_nerima
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学校法人順天堂@juntendo
スポーツ健康科学部@juntendo.sakura
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スポーツ健康科学部juntendo_sakura
研究活動Research Activities

ゲノム・再生医療センター

研究業績データ

主な研究業績(2016年)

1
Matsumoto T, Fujimori K, Andoh-Noda T, Ando T, Kuzumaki N, Toyoshima M, Tada H, Imaizumi K, Ishikawa M, Yamaguchi R, Isoda M, Zhou Z, Sato S, Kobayashi T, Ohtaka M, Nishimura K, Kurosawa H, Yoshikawa T, Takahashi T, Nakanishi M, Ohyama M, Hattori N, Akamatsu W, Okano H.
Functional Neurons Generated from T Cell-Derived Induced Pluripotent Stem Cells for Neurological Disease Modeling.
Stem Cell Reports. 2016 Mar 8;6(3):422-35.
2
Arai S, Kitada K, Yamazaki T, Takai R, Zhang X, Tsugawa Y, Sugisawa R, Matsumoto A, Mori M, Yoshihara Y, Doi K, Maehara N, Kusunoki S, Takahata A, Noiri E, Suzuki Y, Yahagi N, Nishiyama A, Gunaratnam L, Takano T, Miyazaki T.
Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice.
Nat Med. 2016 Feb;22(2):183-93
3
Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, Ma RC, Okada Y, Iwata M, Hosoe J, Shojima N, Iwasaki M, Fujita H, Suzuki K, Danesh J, Jørgensen T, Jørgensen ME, Witte DR, Brandslund I, Christensen C, Hansen T, Mercader JM, Flannick J, Moreno-Macías H, Burtt NP, Zhang R, Kim YJ, Zheng W, Singh JR, Tam CH, Hirose H, Maegawa H, Ito C, Kaku K, Watada H, Tanaka Y, Tobe K, Kawamori R, Kubo M, Cho YS, Chan JC, Sanghera D, Frossard P, Park KS, Shu XO, Kim BJ, Florez JC, Tusié-Luna T, Jia W, Tai ES, Pedersen O, Saleheen D, Maeda S, Kadowaki T.
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
Nat Commun. 2016 Jan 28;7:10531.
4
Cossu D, Yokoyama K, Sechi LA, Otsubo S, Tomizawa Y, Momotani E, Hattori N.
Humoral response against host-mimetic homologous epitopes of Mycobacterium avium subsp. paratuberculosis in Japanese multiple sclerosis patients.
Sci Rep. 2016 Jun 30;6:29227.
5
Tsuboyama, K., Koyama-Honda, I., Sakamaki, Y., Koike, M., Morishita, H., Mizushima, N.
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.
Science 354(6315):1036-41, 2016.
6
Ichiki T, Koga T, Okuno T, Saeki K, Yamamoto Y, Yamamoto H, Sakaguchi M, Yokomizo T.
Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE).
FASEB J. 2016 May;30(5):1811-22.
7
Ishii Y, Saeki K, Liu M, Sasaki F, Koga T, Kitajima K, Meno C, Okuno T, Yokomizo T.
Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.
FASEB J. 2016 Feb;30(2):933-47.
8
Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
Human antimicrobial cathelicidin peptide LL-37 enhances the LPS uptake by liver sinusoidal endothelial cells without cell activation.
J Immunol 196: 1338-1347, 2016.
9
Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T
Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33:Distinct Mechanisms between Subcutaneous and Intranasal Routes.
J Immunol 196: 3559-3569, 2016
10
Kadowaki A*, Miyake S*, Saga R, Chiba A, Mochizuki H, Yamamura T*.
Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3.
Nature Communications. 7:11639, 2016. (*corresponding author)

英文原著(2015年)

(ゲノム・再生医療センター:赤松和土)
1Imaizumi K, Sone T, Ibata K, Fujimori K, Yuzaki M, Akamatsu W, Okano H.
Controlling the Regional Identity of hPSC-Derived Neurons to Uncover Neuronal Subtype Specificity of Neurological Disease Phenotypes.
Stem Cell Reports. 2015 Dec 8;5(6):1010-22.
2Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T.
Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism.
Sci Rep. 2015 Nov 9;5:16239.
3Ohta E, Nihira T, Uchino A, Imaizumi Y, Okada Y, Akamatsu W, Takahashi K, Hayakawa H, Nagai M, Ohyama M, Ryo M, Ogino M, Murayama S, Takashima A, Nishiyama K, Mizuno Y, Mochizuki H, Obata F, Okano H.
I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway..
Hum Mol Genet. 2015 Sep 1;24(17):4879-900.
4Maekawa M, Yamada K, Toyoshima M, Ohnishi T, Iwayama Y, Shimamoto C, Toyota T, Nozaki Y, Balan S, Matsuzaki H, Iwata Y, Suzuki K, Miyashita M, Kikuchi M, Kato M, Okada Y, Akamatsu W, Mori N, Owada Y, Itokawa M, Okano H, Yoshikawa T.
Utility of Scalp Hair Follicles as a Novel Source of Biomarker Genes for Psychiatric Illnesses.
Biol Psychiatry. 2015 Jul 15;78(2):116-25
5Andoh-Noda T, Akamatsu W, Miyake K, Matsumoto T, Yamaguchi R, Sanosaka T, Okada Y, Kobayashi T, Ohyama M, Nakashima K, Kurosawa H, Kubota T, Okano H.
Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.
Mol Brain. 2015 May 27;8:31.
(ゲノム・再生医療センター:服部浩一)
6Heissig B, Dhahri D, Eiamboonsert S, Salama Y, Shimazu H, Munakata S, Hattori K.
Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression.
Cell Mol Life Sci. 2015 Sep 9.
7Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K.
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.
Gastroenterology. 2015 Mar;148(3):565-578.
(腎臓内科)
8Ishizaka M, Gohda T, Takagi M, Omote K, Sonoda Y, Oliva Trejo JA, Asao R, Hidaka T, Asanuma K, Horikoshi S, Tomino Y.
Podocyte-specific deletion of Rac1 leads to aggravation of renal injury in STZ-induced diabetic mice.
Biochem Biophys Res Commun. 2015 Nov 20;467(3):549-55.
9Kim YG, Alvarez M, Suzuki H, Hirose S, Izui S, Tomino Y, Huard B, Suzuki Y.
Pathogenic Role of a Proliferation-Inducing Ligand (APRIL) in Murine IgA Nephropathy.
PLoS One. 2015 Sep 8;10(9):e0137044.
10Fukuda H, Hidaka T, Takagi-Akiba M, Ichimura K, Oliva Trejo JA, Sasaki Y, Wang J, Sakai T, Asanuma K, Tomino Y.
Podocin is translocated to cytoplasm in puromycin aminonucleoside nephrosis rats and in poor-prognosis patients with IgA nephropathy.
Cell Tissue Res. 2015 May;360(2):391-400.
11Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J, Tomino Y.
Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy.
PLoS One. 2015 Apr 10;10(4):e0122212.
(形成外科)
12Tobita M, Tajima S, Mizuno H.
Adipose tissue-derived mesenchymal stem cells and platelet-rich plasma: stem cell transplantation methods that enhance stemness.
Stem Cell Res Ther. 2015 Nov 5;6:215.
13Tajima S, Tobita M, Orbay H, Hyakusoku H and Mizuno H
Direct and indirect effects on bone regeneration of a combination of adipose-derived stem cells and platelet-rich plasma
Tissue Eng Part A 21: 895-905, 2015
(循環器内科)
14Ogita M, Miyauchi K, Tsuboi S, Shitara J, Endo H, Wada H, Doi S, Naito R, Konishi H, Dohi T, Kasai T, Tamura H, Okazaki S, Suwa S, Daida H.
Impact of Combined C-Reactive Protein and High-Density Lipoprotein Cholesterol Levels on Long-Term Outcomes in Patients With Coronary Artery Disease After a First Percutaneous Coronary Intervention.
Am J Cardiol. 2015 Oct 1;116(7):999-1002.
15Konishi H, Miyauchi K, Tsuboi S, Ogita M, Naito R, Dohi T, Kasai T, Tamura H, Okazaki S, Isoda K, Daida H.
Impact of the HAS-BLED Score on Long-Term Outcomes After Percutaneous Coronary Intervention.
Am J Cardiol. 2015 Aug 15;116(4):527-31.
16Suda S, Kasai T, Kato M, Kawana F, Kato T, Ichikawa R, Hayashi H, Kawata T, Sekita G, Itoh S, Daida H.
Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea.
Heart Vessels. 2015 Jul;30(4):554-7.
17Ogita M, Miyauchi K, Kasai T, Doi S, Wada H, Naito R, Konishi H, Tsuboi S, Dohi T, Tamura H, Okazaki S, Daida H.
Impact of preprocedural high-sensitive C-reactive protein levels on long-term clinical outcomes of patients with stable coronary artery disease and chronic kidney disease who were treated with drug-eluting stents.
J Cardiol. 2015 Jul;66(1):15-21.
18Joki Y, Ohashi K, Yuasa D, Shibata R, Ito M, Matsuo K, Kambara T, Uemura Y, Hayakawa S, Hiramatsu-Ito M, Kanemura N, Ogawa H, Daida H, Murohara T, Ouchi N.
FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism.
Biochem Biophys Res Commun. 2015 Mar 27;459(1):124-30.
19Akita K, Isoda K, Shimada K, Daida H.
Dipeptidyl-peptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice.
J Am Heart Assoc. 2015 Mar 13;4(3):e001469.
20Joki Y, Ohashi K, Yuasa D, Shibata R, Kataoka Y, Kambara T, Uemura Y, Matsuo K, Hayakawa S, Hiramatsu-Ito M, Kanemura N, Ito M, Ogawa H, Daida H, Murohara T, Ouchi N.
Neuron-derived neurotrophic factor ameliorates adverse cardiac remodeling after experimental myocardial infarction.
Circ Heart Fail. 2015 Mar;8(2):342-51.
21Hashimoto R, Katoh Y, Miyamoto Y, Itoh S, Daida H, Nakazato Y, Okada T.
Increased extracellular and intracellular Ca² lead to adipocyte accumulation in bone marrow stromal cells by different mechanisms.
Biochem Biophys Res Commun. 2015 Feb 20;457(4):647-52.
22Nonaka R, Iesaki T, de Vega S, Daida H, Okada T, Sasaki T, Arikawa-Hirasawa E.
Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase.
Physiol Rep. 2015 Jan 27;3(1). pii: e12272.
23Konishi H, Miyauchi K, Kasai T, Tsuboi S, Ogita M, Naito R, Sai E, Fukushima Y, Katoh Y, Okai I, Tamura H, Okazaki S, Daida H.
Impact of lipoprotein(a) as residual risk on long-term outcomes in patients after percutaneous coronary intervention.
Am J Cardiol. 2015 Jan 15;115(2):157-60.
24Yoshihara T, Shimada K, Fukao K, Sai E, Sato-Okabayashi Y, Matsumori R, Shiozawa T, Alshahi H, Miyazaki T, Tada N, Daida H.
Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation.
Circ J. 2015;79(7):1470-8.
(代謝内分泌内科)
25Sasaki S, Miyatsuka T, Matsuoka TA, Takahara M, Yamamoto Y, Yasuda T, Kaneto H, Fujitani Y, German MS, Akiyama H, Watada H, Shimomura I.
Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice.
Diabetologia. 2015 Nov;58(11):2582-91.
26Iida H, Ogihara T, Min MK, Hara A, Kim YG, Fujimaki K, Tamaki M, Fujitani Y, Kim H, Watada H.
Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy.
J Mol Endocrinol. 2015 Aug;55(1):41-53.
27Fujimaki K, Ogihara T, Morris DL, Oda H, Iida H, Fujitani Y, Mirmira RG, Evans-Molina C, Watada H.
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.
J Biol Chem. 2015 Jul 3;290(27):16607-18.
28Matsuba R, Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S.
Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes.
PLoS One. 2015 May 7;10(5):e0126363.
29Watada H, Fujitani Y.
Minireview: Autophagy in pancreatic β-cells and its implication in diabetes.
Mol Endocrinol. 2015 Mar;29(3):338-48.
30Nakajima K, Mita T, Osonoi Y, Azuma K, Takasu T, Fujitani Y, Watada H.
Effect of Repetitive Glucose Spike and Hypoglycaemia on Atherosclerosis and Death Rate in Apo E-Deficient Mice.
Int J Endocrinol. 2015;2015:406394.
(脳神経内科)
31Ogaki K, Koga S, Heckman MG, Fiesel FC, Ando M, Labbé C, Lorenzo-Betancor O, Moussaud-Lamodière EL, Soto-Ortolaza AI, Walton RL, Strongosky AJ, Uitti RJ, McCarthy A, Lynch T, Siuda J, Opala G, Rudzinska M, Krygowska-Wajs A, Barcikowska M, Czyzewski K, Puschmann A, Nishioka K, Funayama M, Hattori N, Parisi JE, Petersen RC, Graff-Radford NR, Boeve BF, Springer W, Wszolek ZK, Dickson DW, Ross OA.
Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders.
Neurology. 2015 Dec 8;85(23):2016-25.
32Matsumoto SE, Motoi Y, Ishiguro K, Tabira T, Kametani F, Hasegawa M, Hattori N.
The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties.
Hum Mol Genet. 2015 Nov 15;24(22):6403-16.
33Imai Y, Kobayashi Y, Inoshita T, Meng H, Arano T, Uemura K, Asano T, Yoshimi K, Zhang CL, Matsumoto G, Ohtsuka T, Kageyama R, Kiyonari H, Shioi G, Nukina N, Hattori N, Takahashi R.
The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.
PLoS Genet. 2015 Sep 10;11(9):e1005503.
34Matsumoto G, Shimogori T, Hattori N, Nukina N.
TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation.
Hum Mol Genet. 2015 Aug 1;24(15):4429-42.
35Vaikath NN, Majbour NK, Paleologou KE, Ardah MT, van Dam E, van de Berg WD, Forrest SL, Parkkinen L, Gai WP, Hattori N, Takanashi M, Lee SJ, Mann DM, Imai Y, Halliday GM, Li JY, El-Agnaf OM.
Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology.
Neurobiol Dis. 2015 Jul;79:81-99.
36Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N.
VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.
FEBS Lett. 2015 Jun 4;589(13):1430-6.
37Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N.
High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young-onset parkinsonism.
Neurobiol Aging. 2015 May;36(5):2004.e9-2004.e15.
38Nishikawa N, Shimo Y, Wada M, Hattori N, Kitazawa S.
Effects of aging and idiopathic Parkinson's disease on tactile temporal order judgment.
PLoS One. 2015 Mar 11;10(3):e0118331.
39Ueno Y, Koike M, Shimada Y, Shimura H, Hira K, Tanaka R, Uchiyama Y, Hattori N, Urabe T.
L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain.
Cereb Blood Flow Metab. 2015 Mar;35(3):382-91.
40Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.
CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.
Lancet Neurol. 2015 Mar;14(3):274-82.
41Asano T, Koike M, Sakata S, Takeda Y, Nakagawa T, Hatano T, Ohashi S, Funayama M, Yoshimi K, Asanuma M, Toyokuni S, Mochizuki H, Uchiyama Y, Hattori N, Iwai K.
Possible involvement of iron-induced oxidative insults in neurodegeneration.
Neurosci Lett. 2015 Feb 19;588:29-35.
42Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H, Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N.
Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice.
Hum Mol Genet. 2015 Feb 15;24(4):1092-105.
43Kino Y, Washizu C, Kurosawa M, Oma Y, Hattori N, Ishiura S, Nukina N.
Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins.
Hum Mol Genet. 2015 Feb 1;24(3):740-56
(神経生物学)
44Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N.
VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.
FEBS Lett. 2015 Jun 4;589(13):1430-6.
45Rinchai, D., Riyapa, D., Buddhisa, S., Utispan, K., Titball, R.W., Stevens, P.M., Stevens, J.M., Ogawa, M., Tanida, I., Koike, M., Uchiyama, Y., Ato, M.,
Lertmemongkolchai, G. Macroautophagy is essential for killing of Burkholderia pseudomallei in human neutrophils.
Autophagy 11(5):748-55, 2015.
46Nanao, T.#, Koike, M.#*, Yamaguchi, J., Sasaki, M., Uchiyama, Y.
Cellular localization and tissue distribution of endogenous DFCP1 protein.
Biomed. Res. 36(2):121-33, 2015. (#These authors contributed equally to this work) (*Correspondence author)
47Uemura, N., Koike, M., Asai, K., Kinoshita, M., Fujiwara-Ishikawa, T., Matsui, H., Naruse, K., Sakamoto, N., Uchiyama, Y., Todo, T., Takeda S.I., Yamakado, H., Takahashi, R.
Viable neuronopathic Gaucher disease model in medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein.
Plos Genet. 11(4):e1005065, 2015.
48Nori, S., Okada, Y., Nishimura, S., Sasaki, T., Itakura, G., Kobayashi, Y., Renault-Mihara, F., Shimizu A., Koya, I., Yoshida, R., Kudoh, J., Koike, M., Uchiyama, Y., Ikeda, E., Toyama, Y., Nakamura, M., Okano, H.
Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition.
Stem Cell Reports. 2015 Mar 10;4(3):360-73.
49Asano, T.*, Koike, M.*, Sakata, S., Takeda, Y., Nakagawa, T., Hatano, T., Ohashi, S., Funayama, M., Yoshimi, K., Asanuma, M., Toyokuni, S., Mochizuki, S., Uchiyama, Y., Hattori, N., Iwai, K.
Iron induces mitochondrial damage that recruits parkin.
Neurosci. Lett. 588:29-35, 2015. (*These authors contributed equally to this work)
50Ueno, Y., Koike, M., Shimada, Y., Shimura, H., Uchiyama, Y., Hattori, N., Urabe, T.
L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain.
J. Cereb. Blood Flow Metab. 35(3):382-91, 2015.
51Ichimura, K., Miyazaki, N., Sadayama, S., Murata, K., Koike, M., Nakamura, K., Ohta, K., Sakai, T.
Three-dimensional architecture of podocytes revealed by block-face scanning electron microscopy.
Sci Rep. 2015 Mar 11;5:8993.
(生化学第一)
52Kubota S, Watanabe M, Shirato M, Okuno T, Higashimoto I, Machida K, Yokomizo T, Inoue H.
An inhaled phosphodiesterase 4 inhibitor E6005 suppresses pulmonary inflammation in mice.
Eur J Pharmacol. 2015 Dec 5;768:41-8.
53Asahara M, Ito N, Yokomizo T, Nakamura M, Shimizu T, Yamada Y.
The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.
Mol Pain. 2015 Mar 12;11:11.
54Sawada Y, Honda T, Hanakawa S, Nakamizo S, Murata T, Ueharaguchi-Tanada Y, Ono S, Amano W, Nakajima S, Egawa G, Tanizaki H, Otsuka A, Kitoh A, Dainichi T, Ogawa N, Kobayashi Y, Yokomizo T, Arita M, Nakamura M, Miyachi Y, Kabashima K.
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
J Exp Med. 2015 Oct 19;212(11):1921-30.
55Okuno T, Ishitani T, Yokomizo T.
Biochemical characterization of three BLT receptors in zebrafish.
PLoS One. 2015 Mar 4;10(3):e0117888.
56Zandi S, Nakao S, Chun K H, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn M I, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, Kim Y B, Sweetnam P, Ishibashi T, Hafezi-Moghadam A.
ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration.
Cell reports. 10, 1173-1186, 2015
57Yokomizo T.
Two distinct leukotriene B4 receptors, BLT1 and BLT2.
J Biochem. 2015 Feb;157(2):65-71.
58Liu M, Yokomizo T.
The role of leukotrienes in allergic diseases.
Allergol Int. 2015 Jan;64(1):17-26.
(生化学第二)
59Iba T, Hashiguchi N, Nagaoka I, Tabe Y, Kadota K, Sato K.
Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction.
Intensive Care Med Exp. 2015 Dec;3(1):36.
60Hosoda H, Tamura H, Nagaoka I.
Evaluation of the lipopolysaccharide-induced transcription of the human TREM-1 gene in vitamin D3-matured THP-1 macrophage-like cells.
Int J Mol Med. 2015 Nov;36(5):1300-10.
61Nagura N, Komatsu J, Iwase H, Hosoda H, Ohbayashi O, Nagaoka I, Kaneko K.
Effects of the combination of vitamin K and teriparatide on the bone metabolism in ovariectomized rats
Biomed Rep. 2015 May;3(3):295-300.
(皮膚科)
62Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S
Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection.
Immunol Res 61: 240-249, 2015
63Hasegawa T, Ikeda S
Adipose-derived stromal/stem cells as potential source of skin regeneration.
Stem Cell and Translational Investigation 2015; 2: e787
64Hasegawa T, Sakamoto A, Wada A, Fukai T, Iida H, Ikeda S.
Keratinocyte progenitor cells reside in human subcutaneous adipose tissue.
PLoS One. 2015 Feb 25;10(2):e0118402.
65Arima K, Ohta S, Takagi A, Shiraishi H, msuoka M, Ontsuka K, Suto H, Suzuki S, Yamamoto K, Ogawa M, Simmons O, Yamaguchi Y, Toda S, Aihara M, Consway SJ, Ikeda S, Izuhara K
Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis.
Allergol Int 64: 41-48, 2015
66Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H
Human β-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes.
J Dermatol Sci 77: 46-53, 2016
(免疫学)
67Takenaka S-I, Kaieda S, Kawayama T, Matsuoka M, Kaku Y, Kinoshita T, Sakazaki Y, Okamoto M, Tominaga M, Kanesaki K, Chiba A, Miyake S, Ida H, Hoshino T.
IL-38: A new factor in rheumatoid arthritis.
Biochemistry and Biophysics Reports. 4:386-391, 2015
68Miyake S, Kim S, Suda W, Oshima K, Nakamura M, Matsuoka T, Chihara N, Tomita A, Sato W, Kim SW, Morita H, Hattori M, Yamamura T.
Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters.
PLoS One. 10(9):e0137429, 2015
69Kamachi F, Isshiki T, Harada N, Akiba H, Miyake S.
ICOS promotes group 2 innate lymphoid cell activation in lungs.
Biochem Biophys Res Commun. 463(4):739-45, 2015
(臨床検査医学)
70Mukaida H, Matsushita S, Inotani T, Futaki S, Takano A, Watanabe M, Morita T, Miida T, Amano A.
Peripheral circulation evaluation with near-infrared spectroscopy in skeletal muscle during cardiopulmonary bypass.
Perfusion. 2015 Nov;30(8):653-9.
71Tabe Y, Kojima K, Yamamoto S, Sekihara K, Matsushita H, Davis RE, Wang Z, Ma W, Ishizawa J, Kazuno S, Kauffman M, Shacham S, Fujimura T, Ueno T, Miida T, Andreeff M.
Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185.
PLoS One. 2015 Sep 4;10(9):e0137210.
72Nagasaka H, Hirayama S, Takuwa M, Nakacho M, Yorifuji T, Kondou H, Miida T.
ApoE4 Determines the Reduction in LDL-C After GH Replacement Therapy in Children With an Idiopathic GH Deficiency.
J Clin Endocrinol Metab. 2015 Sep;100(9):3494-501.
73Ashihara E, Munaka T, Kimura S, Nakagawa S, Nakagawa Y, Kanai M, Hirai H, Abe H, Miida T, Yamato S, Shoji S, Maekawa T.
Isopentenyl pyrophosphate secreted from Zoledronate-stimulated myeloma cells, activates the chemotaxis of γδT cells.
Biochem Biophys Res Commun. 2015 Aug 7;463(4):650-5.
74Nishioka E, Hirayama S, Ueno T, Matsukawa T, Vigeh M, Yokoyama K, Makino S, Takeda S, Miida T.
Relationship between maternal thyroid-stimulating hormone (TSH) elevation during pregnancy and low birth weight: a longitudinal study of apparently healthy urban Japanese women at very low risk.
Early Hum Dev. 2015 Mar;91(3):181-5.
75Tabe Y, Yamamoto T, Maenou I, Nakai R, Idei M, Horii T, Miida T, Ohsaka A.
Performance evaluation of the digital cell imaging analyzer DI-60 integrated into the fully automated Sysmex XN hematology analyzer system.
Clin Chem Lab Med. 2015 Feb;53(2):281-9.

英文原著(2014年)

(ゲノム・再生医療センター:赤松和土)
1Matsui T, Akamatsu W, Nakamura M, Okano H.
Regeneration of the damaged central nervous system through reprogramming technology: basic concepts and potential application for cell replacement therapy.
Exp Neurol. 2014 Oct;260:12-8.
2Yoshida T, Ozawa Y, Suzuki K, Yuki K, Ohyama M, Akamatsu W, Matsuzaki Y, Shimmura S, Mitani K, Tsubota K, Okano H.
The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.
Mol Brain. 2014 Jun 16;7:45.
3Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H.
Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
Stem Cell Reports. 2014 Apr 24;2(5):648-61.
(腎臓内科)
4Yamaji K, Suzuki Y, Suzuki H, Satake K, Horikoshi S, Novak J, Tomino Y.
The kinetics of glomerular deposition of nephritogenic IgA.
PLoS One. 2014 Nov 19;9(11):e113005.
5Suzuki Y, Suzuki H, Makita Y, Takahata A, Takahashi K, Muto M, Sasaki Y, Kelimu A, Matsuzaki K, Yanagawa H, Okazaki K, Tomino Y.
Diagnosis and activity assessment of immunoglobulin A nephropathy: current perspectives on noninvasive testing with aberrantly glycosylated immunoglobulin A-related biomarkers.
Int J Nephrol Renovasc Dis. 2014 Oct 30;7:409-14.
6Suzuki Y, Matsuzaki K, Suzuki H, Okazaki K, Yanagawa H, Ieiri N, Sato M, Sato T, Taguma Y, Matsuoka J, Horikoshi S, Novak J, Hotta O, Tomino Y.
Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy.
Clin Exp Nephrol. 2014 Oct;18(5):770-7.
7Wakabayashi K, Hamada C, Kanda R, Nakano T, Io H, Horikoshi S, Tomino Y.
Adipose-derived mesenchymal stem cells transplantation facilitate experimental peritoneal fibrosis repair by suppressing epithelial-mesenchymal transition.
J Nephrol. 2014 Oct;27(5):507-14.
8Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K, Shibuya A, Tomino Y.
Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.
BMC Nephrol. 2014 Jun 13;15:89.
9Omote K, Gohda T, Murakoshi M, Sasaki Y, Kazuno S, Fujimura T, Ishizaka M, Sonoda Y, Tomino Y:
Role of the TNF pathway in the progression of diabetic nephropathy in KK-Ay mice.
Am J Physiol Renal Physiol 306: F1335-1347, 2014
10Yanagawa H, Suzuki H, Suzuki Y, Kiryluk K, Gharavi AG, Matsuoka K, Makita Y, Julian BA, Novak J, Tomino Y.
A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases.
PLoS One. 2014 May 23;9(5):e98081.
11Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y.
Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.
Biochem Biophys Res Commun. 2014 Apr 18;446(4):1190-6.
12Aizawa M, Suzuki Y, Suzuki H, Pang H, Kihara M, Nakata J, Yamaji K, Horikoshi S, Tomino Y.
Uncoupling of glomerular IgA deposition and disease progression in alymphoplasia mice with IgA nephropathy.
PLoS One. 2014 Apr 17;9(4):e95365.
13Suzuki H, Suzuki Y, Novak J, Tomino Y.
Development of Animal Models of Human IgA Nephropathy.
Drug Discov Today Dis Models. 2014 Spring;11:5-11.
14Seto T, Hamada C, Tomino Y.
Suppressive effects of iron overloading on vascular calcification in uremic rats.
J Nephrol. 2014 Apr;27(2):135-42.
(形成外科)
15Masuda H, Tanaka R, Fujimura S, Ishikawa M, Akimaru H, Shizuno T, Sato A, Okada Y, Iida Y, Itoh J, Itoh Y, Kamiguchi H, Kawamoto A, Asahara T.
Vasculogenic conditioning of peripheral blood mononuclear cells promotes endothelial progenitor cell expansion and phenotype transition of anti-inflammatory macrophage and T lymphocyte to cells with regenerative potential.
J Am Heart Assoc. 2014 Jun 25;3(3):e000743.
(循環器内科)
16Ogita M, Miyauchi K, Jiang M, Kasai T, Tsuboi S, Naito R, Konishi H, Dohi T, Yokoyama T, Okazaki S1, Shimada K, Bujo H, Daida H.
Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury.
Atherosclerosis. 2014 Nov;237:374-8.
17Ogita M, Miyauchi K, Miyazaki T, Naito R, Konishi H, Tsuboi S, Dohi T, Kasai T, Yokoyama T, Okazaki S, Kurata T, Daida H.
Low high-density lipoprotein cholesterol is a residual risk factor associated with long-term clinical outcomes in diabetic patients with stable coronary artery disease who achieve optimal control of low-density lipoprotein cholesterol.
Heart Vessels. 29. 35-41. 2014
18Naito R, Miyauchi K, Ogita M, Kasai T, Kawaguchi Y, Tsuboi S, Konishi H, Okazaki S, Kurata T, Daida H.
Impact of admission glycemia and glycosylated hemoglobin A1c on long-term clinical outcomes of non-diabetic patients with acute coronary syndrome.
J Cardiol. 63. 106-111,2014.
19Konishi H, Miyauchi K, Kasai T, Tsuboi S, Ogita M, Naito R, Sai E, Fukushima Y, Katoh Y, Okai I, Tamura H, Okazaki S, Daida H.
Impact of lipoprotein(a) as residual risk on long-term outcomes in patients after percutaneous coronary intervention.
Am J Cardiol. 114. 157-160.2014
20Odagiri F, Inoue H, Sugihara M, Suzuki T, Murayama T, Shioya T, Konishi M, Nakazato Y, Daida H, Sakurai T, Morimoto S, Kurebayashi N.
Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice.
PLoS One. 2014 Jul 7;9(7):e101838.
21Nishizaki Y, Shimada K, Tani S, Ogawa T, Ando J, Takahashi M, Yamamoto M, Shinozaki T, Miyauchi K, Nagao K, Hirayama A, Yoshimura M, Komuro I, Nagai R, Daida H.
Significance of Imbalance in the Ratio of Serum n-3 to n-6 Polyunsaturated Fatty Acids in Patients with Acute Coronary Syndrome,
Am J Cardiol. 113. 441-445. 2014.
22Miyazaki T, Shimada K, Hki M, Kume A, Kitamura Y, Oshida K, Yanagisawa N, Kiyanagi T, Matsumori R, Daida H.
High hexacosanoic acid levels are associated with coronary artery disease.
Atherosclerosis. 223. 429-433. 2014.
(代謝内分泌内科)
23Yamamoto E, Uchida T, Abe H, Taka H, Fujimura T, Komiya K, Hara A, Ogihara T, Fujitani Y, Ueno T, Takeda S, Watada H.
Increased expression of ERp57/GRP58 is protective against pancreatic beta cell death caused by autophagic failure.
Biochem Biophys Res Commun. 2014 Oct 10;453(1):19-24.
24Miyatsuka T, Matsuoka TA, Sasaki S, Kubo F, Shimomura I, Watada H, German MS, Hara M.
Chronological analysis with fluorescent timer reveals unique features of newly generated β-cells.
Diabetes. 2014 Oct;63(10):3388-93.
25Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.
J Clin Invest. 2014 Aug;124(8):3634-44.
26Yasunari E, Mita T, Osonoi Y, Azuma K, Goto H, Ohmura C, Kanazawa A, Kawamori R, Fujitani Y, Watada H.
Repetitive hypoglycemia increases circulating adrenaline level with resultant worsening of intimal thickening after vascular injury in male Goto-Kakizaki rat carotid artery.
Endocrinology. 2014 Jun;155(6):2244-53.
(脳神経内科)
27Shiba-Fukushima K, Arano T, Matsumoto G, Inoshita T, Yoshida S, Ishihama Y, Ryu KY, Nukina N, Hattori N, Imai Y.
Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.
PLoS Genet. 2014 Dec 4;10(12):e1004861.
28Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy.
J Biol Chem. 2014 Nov 28;289(48):33131-6.
29Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.
Nat Commun. 2014 Nov 21;5:5525.
30Miyazaki H, Oyama F, Inoue R, Aosaki T, Abe T, Kiyonari H, Kino Y, Kurosawa M, Shimizu J, Ogiwara I, Yamakawa K, Koshimizu Y, Fujiyama F, Kaneko T, Shimizu H, Nagatomo K, Yamada K, Shimogori T, Hattori N, Miura M, Nukina N.
Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.
Nat Commun. 2014 Nov 21;5:5525.
31Hatano T、Funayama M、Kubo S、Mata IF、Oji Y、Mori A、Zabetian CP、Waldherr SM、Yoshino H、Oyama G、Shimo Y、Fujimoto K、Oshima H、Kunii Y、Yabe H、Mizuno Y、Hattori N.
Identification of a Japanese family with LRRK2 p.R1441G-related Parkinson's disease.
Neurobiol Aging. 2014 Nov;35(11):2656.e17-23. 
32Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J.
Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Nat Commun. 2014 Oct 15;5:5182.
33Amo T, Saiki S, Sawayama T, Sato S, Hattori N.
Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.
Neurosci Lett. 2014 Sep 19;580:37-40.
34Yamashita C, Tomiyama H, Funayama M, Inamizu S, Ando M, Li Y, Yoshino H, Araki T, Ichikawa T, Ehara Y, Ishikawa K, Mizusawa H, Hattori N.
Evaluation of polyglutamine repeats in autosomal dominant Parkinson's disease.
Neurobiol Aging. 2014 Jul;35(7):1779.e17-21.
35Fujimaki T, Saiki S, Tashiro E, Yamada D, Kitagawa M, Hattori N, Imoto M.
Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.
PLoS One. 2014 Jun 24;9(6):e100395.
36Shiba-Fukushima K, Inoshita T, Hattori N, Imai Y.
PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila.
PLoS Genet. 2014 Jun 5;10(6):e1004391.
37Nishioka K, Funayama M, Vilariño-Güell C, Ogaki K, Li Y, Sasaki R, Kokubo Y, Kuzuhara S, Kachergus JM, Cobb SA, Takahashi H, Mizuno Y, Farrer MJ, Ross OA, Hattori N.
EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population.
Parkinsonism Relat Disord. 2014 Jun;20(6):659-61.
(神経生物学)
38Shigihara N, Fukunaka A, Hara A, Komiya K, Honda A, Uchida T, Abe H, Toyofuku Y, Tamaki M, Ogihara T, Miyatsuka T, Hiddinga HJ, Sakagashira S, Koike M, Uchiyama Y, Yoshimori T, Eberhardt NL, Fujitani Y, Watada H.
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagy.
J Clin Invest. 2014 Aug;124(8):3634-44.
39Bartolomé, A., Kimura-Koyanagi, M., Asahara, S., Guillén, C., Teruyama, K., Inoue, H., Shimizu, S., Kanno, A., García-Aguilar, A., Koike, M., Uchiyama, Y., Benito, M., Noda, T., Kido, Y.
Pancreatic βcell failure mediated by mTORC1 hyperactivity and autophagic impairment.
Diabetes 63(9):2996-3008, 2014.
(生化学第一)
40Obinata H, Gutkind S, Stitham J, Okuno T, Yokomizo T, Hwa J, Hla T.
Individual variation of human S1P coding sequence leads to heterogeneity in receptor function and drug interactions.
J Lipid Res. 2014 Dec;55(12):2665-75.
41Sato Y, Hara H, Okuno T, Ozaki N, Suzuki S, Yokomizo T, Kaisho T, Yoshida H.
IL-27 affects helper T cell responses via regulation of PGE2 production by macrophages.
Biochem Biophys Res Commun. 451, 215-221, 2014
42Dugu L, Nakahara T, Wu Z, Uchi H, Liu M, Hirano K, Yokomizo T, Furue M.
Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.
J Dermatol Sci. 73, 225-231, 2014
43Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T. 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.
J Exp Med. 211, 1063-1078, 2014
(生化学第二)
44Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I:
Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.
PLoS ONE 9: e85765, 2014.
45Ochiai T, Nishimura K, Watanabe T, Kitajima M, Nakatani A, Sato T, Kishine K, Futagawa S, Mashiko S, Nagaoka I.
Mechanism underlying the transient increase of serum iron during FOLFOX/FOLFIRI therapy.
Mol Clin Oncol. 2014 Nov;2(6):968-972.
46Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I.
Is the neutrophil a 'prima donna' in the procoagulant process during sepsis?
Crit Care. 2014 Jul 9;18(4):230.
47Wakabayashi S, Yamaguchi K, Kumakura S, Murakami T, Someya A, Kajiyama Y, Nagaoka I, Inada E.
Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy.
Int J Mol Med. 2014 Jul;34(1):137-44.
48Iba T, Miki T, Hashiguchi N, Tabe Y, Nagaoka I.
Combination of antithrombin and recombinant thrombomodulin modulates neutrophil cell-death and decreases circulating DAMPs levels in endotoxemic rats.
Thromb Res. 2014 Jul;134(1):169-73.
49Iba T, Miki T, Hashiguchi N, Yamada A, Nagaoka I.
Combination of antithrombin and recombinant thrombomodulin attenuates leukocyte-endothelial interaction and suppresses the increase of intrinsic damage-associated molecular patterns in endotoxemic rats.
J Surg Res. 2014 Apr;187(2):581-6.
(皮膚科)
50Ishii S, Hasegawa T, Hirasawa Y, Tsunemi Y, Kawashima M, Ikeda S.
Acute generalized exanthematous pustulosis induced by oral prednisolone.
J Dermatol. 2014 Dec;41(12):1135-6
51Nakahara T, Takagi A, Yamagami J, Kamiya K, Aoyama Y, Iwatsuki K, Ikeda S.
High anti–desmoglein 3 antibody ELISA index and negative indirect immunofluorescence result in a patient with pemphigus vulgaris in remission: evaluation of the antibody profile by newly developed methods.
JAMA Dermatol. 2014 Dec;150(12):1327-30.
52Wakabayashi M, Hasegawa T, Yamaguchi T, Funakusi N, Suto H, Ueki R, Kobayashi H, Ogawa H, Ikeda S
Yokukansan, a traditional Japanese medicine, adjusts glutamate signaling in cultured keratinocytes.
Biomed Res Int 2014: 364092, 2014
53Yoshihara N, Nakano H, Sawamura D, Ikeda S
Novel missense mutation of COL7A1 in a recessive dystrophic epidermolysis bullosa patient with mild clinical phenotype.
J Dermatol 41: 939-940, 2014
54Mabuchi T, Ota T, Manabe Y, Ikoma N, Ozawa A, Terui T, Ikeda S, Inoko H, Oka A.
HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese.
J Dermatol. 2014 Aug;41(8):697-704.
55Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Hara M, Okumura K, Ikeda S, Ogawa H.
Host defense (Antimicrobial) peptide, human β-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes.
J Invest Dermatol. 2014 Aug;134(8):2163-73.
56Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S.
Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner.
Allergol Int. 2014 Jun;63(2):219-26.
57Hiruma M, Cho O, Hiruma M, Kurakado S, Sugita T, Ikeda S.
Genotype analyses of human commensal scalp fungi, Malassezia globosa, and Malassezia restricta on the scalps of patients with dandruff and healthy subjects.
Mycopathologia. 2014 Jun;177(5-6):263-9.
58Yoshihara N, Takagi A, Ueno T, Ikeda S.
Inverse correlation between microtubule-associated protein 1A/1B-light chain 3 and p62/sequestosome-1 expression in the progression of cutaneous squamous cell carcinoma.
J Dermatol. 2014 Apr;41(4):311-5.
(免疫学)
59Nakamura M, Matsuoka T, Chihara N, Miyake S, Sato W, Araki M, Okamoto T, Lin Y, Ogawa M, Murata M, Aranami T, Yamamura T.
Differential effects of fingolimod on B-cell populations in multilse sclerosis.
Mult Scler. 20(10):1371-80,2014
60Noto D*, Sakuma H*, Takahashi K, Yamada M, Yamamura T, Miyake S*.
Development of a culture system to induce microglia-like cells from hematopoietic cells.
Neuropathol Appl Neurobiol 40(6):697-713,2014. (*corresponding author)
(臨床検査医学)
61Miida T, Nishimura K, Okamura T, Hirayama S, Ohmura H, Yoshida H, Miyashita Y, Ai M, Tanaka A, Sumino H, Murakami M, Inoue I, Kayamori Y, Nakamura M, Nobori T, Miyazawa Y, Teramoto T, Yokoyama S.
Validation of homogeneous assays for HDL-cholesterol using fresh samples from healthy and diseased subjects.
Atherosclerosis, Vol. 233, No. 1, 253-259, 2014.
62Yokoyama S, Ueshima H, Miida T, Nakamura M, Takata K, Fukukawa T, Goto T, Harada-Shiba M, Sano M, Kato K, Matsuda K.
High-density lipoprotein levels have markedly increased over the past twenty years in Japan.
J Atheroscler Thromb, Vol. 21, No. 2, 151-160, 2014.
63Idei M, Hirayama S, Miyake N, Kon M, Horiuchi Y, Ueno T, Miyake K, Sato N, Yoshii H, Yamashiro K, Onuma T, Miida T.
The mean postprandial triglyceride concentration is an independent risk factor of carotid atherosclerosis in patients with type 2 diabetes.
Clin Chim Acta, Vol. 430, 134-139, 2014.
64Yamaguchi S, Zhang B, Tomonaga T, Seino U, Kanagawa A, Nagasaka H, Suzuki A, Miida T, Yamada S, Sasaguri Y, Doi T, Saku K, Okazaki M, Tochino Y, Hirano K.
Selective evaluation of high density lipoprotein from mouse small intestines by an in situ perfusion technique.
J Lipid Res, Vol. 55, No. 5, 905–918, 2014.
65Shoji H, Murano Y, Mori M, Matsunaga N, Ohkawa N, Suganuma H, Ikeno M, Hisata K, Hirayama S, Ueno T, Miida T, Shimizu T.
Lipid profile and atherogenic indices soon after birth in Japanese preterm infants.
Acta Paediatr, Vol. 103, No. 1, 22-26, 2014.
66Nagasaka H, Tsukahara H, Okano Y, Hirano K, Sakurai T, Hui S-P, Ohura T, Usui H, Yorifuji T, Hirayama S, Ohtake A, Miida T.
Changes of lipoproteins in phenylalanine hydroxylase-deficient children for the first early of life.
Clin Chim Acta, Vol. 433, 1-4, 2014.
67Ikeda N, Shoji H, Murano Y, Mori M, Matsunaga N, Suganuma H, Ikeno M, Hisata K, Hirayama S, Ueno T, Miida T, Shimizu T.
Effects of breastfeeding on the risk factors for metabolic syndrome in preterm infants.
J Dev Orig Health Dis, Vol. 5, No. 6, 459-464, 2014.
68Tabe Y, Jin L, Konopleva M, Shikami M, Kimura S, Andreeff M, Raffeld M, Miida T.
Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma.
Acta Haematol, Vol. 131, No. 1, 59-69, 2014.
69Nishioka E, Yokoyama K, Matsukawa T, Vigeh M, Hirayama S, Ueno T, Miida T, Makino S, Takeda S.
Evidence that birth weight is decreased by lead at its maternal levels below 5μg/dl in male but not in female newborns.
Reprod Toxicol, Vol. 47, 21-26, 2014.

日本語論文

1鈴木 香, 長岡 功:
Cathelicidinファミリーの抗菌ペプチドLL-37によるエンドトキシン除去作用.
エンドトキシン・自然免疫研究18. 長岡 功, 横地高志 編集, 医学図書出版, 東京, 2015(印刷中)